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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SOX17

Z-value: 1.56

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Transcription factors associated with SOX17

Gene Symbol	Gene ID	Gene Info
SOX17 Ensembl NCBI GeneCards UniProt	ENSG00000164736.5	SOX17

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SOX17	chr8_55366717_55366868	3703	0.302189	-0.81	8.5e-03	Click!
SOX17	chr8_55379558_55379709	9138	0.261717	-0.74	2.2e-02	Click!
SOX17	chr8_55367558_55367715	2859	0.336887	-0.66	5.3e-02	Click!
SOX17	chr8_55366934_55367085	3486	0.309113	-0.62	7.7e-02	Click!
SOX17	chr8_55366358_55366509	4062	0.292759	-0.62	7.7e-02	Click!

Activity of the SOX17 motif across conditions

Conditions sorted by the z-value of the SOX17 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr4_79575534_79575744	0.39	ENSG00000238816	.	14385	0.21
chr18_46270227_46270648	0.36	RP11-426J5.2		55647	0.13
chr11_67141426_67142374	0.35	CLCF1	cardiotrophin-like cytokine factor 1	252	0.81
chr20_9239531_9239912	0.35	PLCB4	phospholipase C, beta 4	41684	0.21
chr12_118124324_118124475	0.35	KSR2	kinase suppressor of ras 2	12203	0.3
chr13_76225766_76225917	0.34	LMO7	LIM domain 7	15382	0.17
chr1_221099074_221099301	0.33	HLX	H2.0-like homeobox	44603	0.15
chr11_34449252_34449782	0.32	CAT	catalase	10955	0.23
chr4_114305053_114305337	0.31	ANK2	ankyrin 2, neuronal	10680	0.22
chr5_90603533_90603789	0.31	ENSG00000199643	.	37117	0.18
chr11_73024899_73025487	0.31	ARHGEF17	Rho guanine nucleotide exchange factor (GEF) 17	2583	0.2
chr15_67055010_67055873	0.30	SMAD6	SMAD family member 6	51406	0.15
chr9_91390340_91390723	0.30	ENSG00000265873	.	29711	0.24
chr7_26893246_26893503	0.29	SKAP2	src kinase associated phosphoprotein 2	3865	0.32
chr8_95983279_95983772	0.29	NDUFAF6	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6	9636	0.15
chr10_706571_706722	0.29	RP11-809C18.5		2852	0.21
chr1_185368997_185369148	0.29	ENSG00000252407	.	34304	0.19
chr10_28004089_28004350	0.27	MKX	mohawk homeobox	28255	0.18
chr10_80022765_80022916	0.27	ENSG00000201393	.	104424	0.08
chr10_78318665_78318816	0.26	RP11-325D15.2		2012	0.47
chr6_82886298_82886449	0.26	ENSG00000223044	.	33784	0.21
chr7_80264220_80264371	0.26	CD36	CD36 molecule (thrombospondin receptor)	3665	0.37
chr2_238318033_238318184	0.26	COL6A3	collagen, type VI, alpha 3	4683	0.23
chr13_28534615_28535489	0.26	CDX2	caudal type homeobox 2	10224	0.14
chr5_158173853_158174004	0.26	CTD-2363C16.1		236086	0.02
chr6_16391457_16391608	0.26	ENSG00000265642	.	37222	0.21
chr11_118475244_118475483	0.25	PHLDB1	pleckstrin homology-like domain, family B, member 1	1792	0.23
chr16_75278250_75278858	0.25	BCAR1	breast cancer anti-estrogen resistance 1	1954	0.25
chr7_77079843_77080131	0.25	ENSG00000238453	.	26882	0.19
chr10_90724518_90724791	0.25	ACTA2	actin, alpha 2, smooth muscle, aorta	12124	0.15
chr3_29555706_29555931	0.24	RBMS3-AS2	RBMS3 antisense RNA 2	102728	0.08
chr12_20658278_20658429	0.24	RP11-284H19.1		135157	0.05
chr1_68048532_68048683	0.24	ENSG00000207504	.	41797	0.16
chr5_93581719_93582069	0.24	FAM172A	family with sequence similarity 172, member A	134513	0.05
chr12_15950766_15950967	0.24	EPS8	epidermal growth factor receptor pathway substrate 8	8356	0.28
chr6_116733337_116733739	0.24	DSE	dermatan sulfate epimerase	41428	0.1
chr10_4720032_4720183	0.24	AKR1E2	aldo-keto reductase family 1, member E2	108714	0.07
chr2_159365928_159366227	0.23	ENSG00000251721	.	24635	0.18
chr6_134299599_134299750	0.23	TBPL1	TBP-like 1	25312	0.21
chr7_18794771_18794922	0.23	ENSG00000222164	.	53056	0.17
chr3_177624604_177624755	0.23	ENSG00000199858	.	100888	0.09
chr4_88727397_88727610	0.23	IBSP	integrin-binding sialoprotein	6770	0.18
chr5_53949820_53950094	0.23	SNX18	sorting nexin 18	136364	0.05
chr7_80414599_80414988	0.23	CD36	CD36 molecule (thrombospondin receptor)	112101	0.07
chr1_235053615_235054079	0.23	ENSG00000239690	.	13914	0.26
chr1_94761220_94761475	0.23	ARHGAP29	Rho GTPase activating protein 29	58158	0.14
chr4_19776674_19776825	0.23	SLIT2	slit homolog 2 (Drosophila)	478134	0.01
chr12_63292090_63292337	0.23	PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H	36604	0.16
chr2_191706793_191706944	0.22	GLS	glutaminase	38685	0.16
chr9_114721568_114721719	0.22	ENSG00000266315	.	27263	0.16
chr7_80415975_80416126	0.22	CD36	CD36 molecule (thrombospondin receptor)	113358	0.07
chr19_33885604_33886026	0.22	CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	20597	0.19
chr17_36607297_36607925	0.22	ENSG00000260833	.	321	0.87
chr15_39438573_39438724	0.22	RP11-624L4.1		27734	0.25
chr12_102288439_102288933	0.22	DRAM1	DNA-damage regulated autophagy modulator 1	13406	0.14
chr8_48435057_48435320	0.22	RP11-697N18.4		4771	0.31
chr4_129388350_129388501	0.22	PGRMC2	progesterone receptor membrane component 2	178441	0.03
chr2_69480804_69480955	0.22	ENSG00000199460	.	70870	0.09
chr2_173995015_173995166	0.22	MLTK	Mitogen-activated protein kinase kinase kinase MLT	39743	0.17
chr12_120130068_120130348	0.22	RP1-127H14.3	Uncharacterized protein	7365	0.17
chr2_102686423_102686780	0.22	IL1R1	interleukin 1 receptor, type I	235	0.95
chr9_112942282_112942517	0.22	C9orf152	chromosome 9 open reading frame 152	28070	0.2
chr5_67667888_67668039	0.21	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	79567	0.11
chr2_213462726_213462977	0.21	ERBB4	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	59286	0.16
chr8_22562900_22563666	0.21	EGR3	early growth response 3	12468	0.13
chr4_41015470_41015621	0.21	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	857	0.64
chr15_39997484_39997635	0.21	RP11-37C7.3		77213	0.08
chr4_174337071_174337307	0.21	SCRG1	stimulator of chondrogenesis 1	16502	0.15
chr3_43582591_43582742	0.21	ANO10	anoctamin 10	14237	0.25
chr6_152894974_152895125	0.21	RP11-133I21.2		27981	0.2
chr3_149183835_149183986	0.21	TM4SF4	transmembrane 4 L six family member 4	7851	0.22
chr9_4302715_4302866	0.21	GLIS3	GLIS family zinc finger 3	2874	0.27
chr12_27519472_27519623	0.21	ARNTL2	aryl hydrocarbon receptor nuclear translocator-like 2	1681	0.44
chr18_59660622_59660853	0.21	RNF152	ring finger protein 152	99273	0.08
chr2_226986115_226986427	0.21	ENSG00000263363	.	537238	0.0
chr15_33210698_33210849	0.21	FMN1	formin 1	7688	0.22
chr7_116804373_116804524	0.21	ST7-AS2	ST7 antisense RNA 2	17914	0.23
chr6_130707481_130707632	0.21	TMEM200A	transmembrane protein 200A	20677	0.2
chr5_121428399_121428550	0.21	LOX	lysyl oxidase	14494	0.2
chr12_11864478_11864709	0.21	ETV6	ets variant 6	40842	0.2
chr3_119305313_119305668	0.21	ADPRH	ADP-ribosylarginine hydrolase	4578	0.16
chr1_97718242_97718393	0.20	DPYD-AS1	DPYD antisense RNA 1	156838	0.04
chr8_59870660_59870811	0.20	RP11-328K2.1		34762	0.22
chr12_109213549_109213779	0.20	SSH1	slingshot protein phosphatase 1	6398	0.16
chr22_46439284_46440015	0.20	RP6-109B7.5		9324	0.11
chr8_25781818_25781969	0.20	EBF2	early B-cell factor 2	36461	0.23
chr3_149165689_149165973	0.20	TM4SF4	transmembrane 4 L six family member 4	25930	0.17
chr5_64337018_64337402	0.20	ENSG00000207439	.	81986	0.11
chr8_123197757_123197908	0.20	ENSG00000238901	.	485698	0.01
chr5_158428554_158428967	0.20	CTD-2363C16.2		15946	0.22
chr10_114788206_114788458	0.20	RP11-57H14.2		76698	0.1
chr3_90060750_90060901	0.20	ENSG00000212598	.	18609	0.3
chr8_78478320_78478688	0.20	ENSG00000222334	.	279452	0.02
chr4_139143123_139143274	0.20	SLC7A11	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	20305	0.25
chr4_81172882_81173033	0.20	FGF5	fibroblast growth factor 5	14796	0.23
chr1_150779693_150780543	0.20	CTSK	cathepsin K	208	0.91
chr20_48345752_48345903	0.20	ENSG00000264946	.	7341	0.19
chr12_101692527_101692678	0.20	UTP20	UTP20, small subunit (SSU) processome component, homolog (yeast)	18715	0.19
chr11_14280223_14280374	0.19	RP11-21L19.1		14939	0.24
chr5_143416527_143416678	0.19	ENSG00000239390	.	103842	0.07
chr16_4001736_4001887	0.19	RP11-462G12.1		1366	0.4
chr11_77034277_77034428	0.19	PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	25980	0.19
chr8_119944366_119944655	0.19	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	19929	0.23
chr1_244014136_244014917	0.19	AKT3	v-akt murine thymoma viral oncogene homolog 3	145	0.97
chr3_30273256_30273457	0.19	ENSG00000199927	.	72671	0.11
chr2_9106079_9106230	0.19	ENSG00000238888	.	12870	0.25
chr1_178244906_178245188	0.19	RASAL2	RAS protein activator like 2	65559	0.14
chr17_76385949_76386473	0.19	ENSG00000200063	.	9805	0.13
chr11_32054621_32054772	0.19	RP1-17K7.2		8098	0.17
chr7_134938605_134938973	0.19	STRA8	stimulated by retinoic acid 8	22058	0.17
chr9_79207509_79207915	0.19	ENSG00000241781	.	20981	0.22
chr3_112497948_112498099	0.19	ENSG00000242770	.	23302	0.22
chr21_44417521_44417672	0.19	PKNOX1	PBX/knotted 1 homeobox 1	22845	0.15
chr5_149530280_149530569	0.19	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	4766	0.17
chr5_172226180_172226429	0.19	ENSG00000206741	.	19207	0.13
chr9_2085870_2086021	0.19	RP11-264I13.2		39922	0.18
chr7_81771662_81771813	0.19	MIR1255B1	microRNA 1255b-1	133229	0.05
chr9_16625723_16625874	0.19	RP11-62F24.1		124	0.98
chr9_89213139_89213290	0.19	ENSG00000222293	.	175171	0.03
chrX_39949861_39950479	0.19	BCOR	BCL6 corepressor	6486	0.33
chr6_3472796_3472947	0.19	SLC22A23	solute carrier family 22, member 23	15615	0.27
chr14_38020205_38020356	0.19	FOXA1	forkhead box A1	43959	0.16
chr13_109597565_109597716	0.19	MYO16	myosin XVI	59123	0.16
chr14_61611936_61612087	0.19	PRKCH	protein kinase C, eta	42266	0.17
chr5_64493902_64494516	0.19	ENSG00000207439	.	75013	0.12
chr12_102319723_102319998	0.19	RP11-512N21.3		1363	0.4
chr12_20625127_20625278	0.19	RP11-284H19.1		102006	0.08
chr1_240399314_240399591	0.19	FMN2	formin 2	9108	0.25
chr1_22251707_22252306	0.19	HSPG2	heparan sulfate proteoglycan 2	11784	0.15
chr8_59801983_59802134	0.19	ENSG00000201231	.	74947	0.11
chr9_113606609_113606760	0.19	ENSG00000206923	.	58933	0.13
chr7_134512008_134512159	0.19	CALD1	caldesmon 1	16552	0.27
chr3_29226532_29226683	0.19	RBMS3	RNA binding motif, single stranded interacting protein 3	95866	0.08
chr8_116477187_116477365	0.19	TRPS1	trichorhinophalangeal syndrome I	27172	0.23
chr21_40392911_40393288	0.19	ENSG00000272015	.	126390	0.05
chr11_87156993_87157144	0.19	ENSG00000223015	.	160607	0.04
chr5_88831623_88831774	0.19	MEF2C-AS1	MEF2C antisense RNA 1	117074	0.07
chr18_448002_448153	0.19	RP11-720L2.2		23661	0.19
chr3_81501815_81501966	0.19	ENSG00000222389	.	56737	0.18
chr8_21542340_21542522	0.19	GFRA2	GDNF family receptor alpha 2	103404	0.07
chr7_84252921_84253072	0.18	ENSG00000265050	.	42328	0.21
chr12_6472663_6473337	0.18	SCNN1A	sodium channel, non-voltage-gated 1 alpha subunit	313	0.83
chr3_151102482_151102667	0.18	P2RY12	purinergic receptor P2Y, G-protein coupled, 12	26	0.98
chr7_28064670_28064821	0.18	JAZF1	JAZF zinc finger 1	4327	0.32
chr8_130655393_130655686	0.18	GSDMC	gasdermin C	143595	0.04
chr8_97024655_97024806	0.18	GDF6	growth differentiation factor 6	148290	0.04
chr9_137118247_137118684	0.18	ENSG00000221676	.	88779	0.07
chr6_85535174_85535325	0.18	TBX18	T-box 18	61012	0.16
chr2_169385393_169385803	0.18	ENSG00000265694	.	53855	0.12
chr15_77518685_77518901	0.18	PEAK1	pseudopodium-enriched atypical kinase 1	26080	0.24
chr12_66441049_66441200	0.18	ENSG00000251857	.	18877	0.2
chr11_130348992_130349281	0.18	ADAMTS15	ADAM metallopeptidase with thrombospondin type 1 motif, 15	30267	0.21
chr3_73651209_73651360	0.18	ENSG00000239119	.	8131	0.21
chr4_74898801_74899032	0.18	CXCL3	chemokine (C-X-C motif) ligand 3	5490	0.15
chr3_135794311_135794474	0.18	RP11-305O4.3		12363	0.25
chr8_49439487_49439638	0.18	RP11-770E5.1		24565	0.27
chr2_69314906_69315057	0.18	ANTXR1	anthrax toxin receptor 1	12246	0.2
chr3_29931035_29931186	0.18	RBMS3-AS1	RBMS3 antisense RNA 1	44537	0.21
chrX_111881069_111881367	0.18	ENSG00000200436	.	23667	0.22
chr2_162963271_162963422	0.18	DPP4	dipeptidyl-peptidase 4	32294	0.15
chr15_43797657_43797855	0.18	TP53BP1	tumor protein p53 binding protein 1	5056	0.16
chr4_89491580_89491731	0.18	ENSG00000252322	.	13468	0.16
chr18_10377014_10377165	0.18	ENSG00000239031	.	12908	0.27
chr6_134084843_134084994	0.18	RP3-323P13.2		3828	0.35
chr4_146728993_146729144	0.18	RP11-181K12.2		25202	0.2
chr14_90389082_90389233	0.18	EFCAB11	EF-hand calcium binding domain 11	31710	0.18
chr10_13981760_13981911	0.18	FRMD4A	FERM domain containing 4A	32534	0.19
chr12_58924723_58924874	0.18	RP11-362K2.2	Protein LOC100506869	13109	0.31
chr5_67628013_67628218	0.18	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	39719	0.21
chr10_79992002_79992207	0.18	ENSG00000201393	.	135160	0.05
chr7_81267105_81267256	0.18	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	125132	0.06
chr1_231837911_231838062	0.18	ENSG00000222986	.	31605	0.2
chr8_7251752_7252001	0.18	ZNF705G	zinc finger protein 705G	8796	0.15
chr2_217180969_217181120	0.18	AC069155.1		12996	0.17
chr1_240262420_240262571	0.18	FMN2	formin 2	7315	0.26
chr8_67067455_67067606	0.18	CRH	corticotropin releasing hormone	23430	0.21
chr2_189834856_189835007	0.18	COL3A1	collagen, type III, alpha 1	4115	0.26
chr12_26784440_26784591	0.18	RP11-666F17.1		8213	0.3
chr3_29329993_29330144	0.18	RBMS3-AS3	RBMS3 antisense RNA 3	2149	0.36
chr7_34025958_34026171	0.18	BMPER	BMP binding endothelial regulator	80919	0.11
chr6_109992699_109992850	0.18	AK9	adenylate kinase 9	8914	0.23
chr7_75273876_75274027	0.18	HIP1	huntingtin interacting protein 1	32790	0.16
chr12_25876644_25876795	0.18	ENSG00000222950	.	55784	0.14
chr9_79075654_79076239	0.18	GCNT1	glucosaminyl (N-acetyl) transferase 1, core 2	1800	0.46
chr2_189674111_189674262	0.18	DIRC1	disrupted in renal carcinoma 1	19355	0.22
chr14_52192816_52192967	0.18	ENSG00000207004	.	2070	0.29
chr11_3980211_3980997	0.18	STIM1	stromal interaction molecule 1	12031	0.18
chr10_119215065_119215278	0.18	EMX2OS	EMX2 opposite strand/antisense RNA	21513	0.22
chr17_13268235_13268519	0.18	ENSG00000266115	.	135268	0.05
chr7_98705625_98705861	0.18	SMURF1	SMAD specific E3 ubiquitin protein ligase 1	35899	0.17
chr5_176972744_176973255	0.18	FAM193B	family with sequence similarity 193, member B	6647	0.12
chr9_15936653_15936804	0.18	CCDC171	coiled-coil domain containing 171	158962	0.04
chr1_211999301_211999452	0.17	RP11-552D8.1		3812	0.19
chr3_141163664_141163815	0.17	ZBTB38	zinc finger and BTB domain containing 38	13174	0.22
chr16_72570911_72571062	0.17	ENSG00000221286	.	42550	0.18
chr3_100736189_100736340	0.17	ABI3BP	ABI family, member 3 (NESH) binding protein	23905	0.23
chr12_56917827_56917978	0.17	RBMS2	RNA binding motif, single stranded interacting protein 2	2119	0.23
chr18_39579349_39579630	0.17	PIK3C3	phosphatidylinositol 3-kinase, catalytic subunit type 3	25806	0.28
chr19_15321258_15321624	0.17	NOTCH3	notch 3	9649	0.16
chr3_171704686_171704902	0.17	FNDC3B	fibronectin type III domain containing 3B	52624	0.15

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX17

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.1	0.3	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.1	0.3	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.4	GO:0071731	response to nitric oxide(GO:0071731)
0.1	0.2	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.1	0.2	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.3	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.4	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1	0.2	GO:0035581	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.2	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.2	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.1	0.3	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.1	0.3	GO:0048625	myoblast fate commitment(GO:0048625)
0.1	0.2	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1	0.1	GO:0019511	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.1	0.2	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.2	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.0	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.2	GO:0051014	actin filament severing(GO:0051014)
0.0	0.2	GO:2000831	corticosteroid hormone secretion(GO:0035930) regulation of steroid hormone secretion(GO:2000831) regulation of corticosteroid hormone secretion(GO:2000846)
0.0	0.1	GO:0032344	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.2	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.3	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.2	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.0	GO:0009151	purine deoxyribonucleotide metabolic process(GO:0009151)
0.0	0.1	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.2	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0060013	righting reflex(GO:0060013)
0.0	0.2	GO:0048520	positive regulation of behavior(GO:0048520)
0.0	0.1	GO:0097531	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	0.0	GO:0045188	circadian sleep/wake cycle, non-REM sleep(GO:0042748) regulation of circadian sleep/wake cycle, non-REM sleep(GO:0045188)
0.0	0.1	GO:0035929	steroid hormone secretion(GO:0035929)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.2	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0	0.0	GO:0035844	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.3	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0010996	response to auditory stimulus(GO:0010996) auditory behavior(GO:0031223)
0.0	0.1	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.0	GO:0045992	negative regulation of embryonic development(GO:0045992)
0.0	0.1	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.1	GO:0042637	catagen(GO:0042637)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.2	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.1	GO:1903672	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.1	GO:0014721	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.1	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.2	GO:1901976	regulation of cell cycle checkpoint(GO:1901976)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.2	GO:0043206	extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0	0.1	GO:0060687	regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0009169	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.2	GO:0048844	artery morphogenesis(GO:0048844)
0.0	0.1	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.0	GO:0050965	detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0	0.2	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.0	GO:0021800	cerebral cortex tangential migration(GO:0021800)
0.0	0.1	GO:0019532	oxalate transport(GO:0019532)
0.0	0.0	GO:0010159	specification of organ position(GO:0010159)
0.0	0.1	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.2	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.1	GO:0046487	glyoxylate metabolic process(GO:0046487)
0.0	0.1	GO:0008615	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.0	GO:0021508	floor plate formation(GO:0021508)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.1	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.0	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.1	GO:0048680	positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0	0.0	GO:0070254	mucus secretion(GO:0070254)
0.0	0.0	GO:0061298	retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.2	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0	0.1	GO:0090281	negative regulation of calcium ion import(GO:0090281) negative regulation of cation transmembrane transport(GO:1904063)
0.0	0.0	GO:0021823	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	0.2	GO:0043277	apoptotic cell clearance(GO:0043277)
0.0	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.3	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.0	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0	0.1	GO:0051290	protein heterotetramerization(GO:0051290)
0.0	0.1	GO:0060996	dendritic spine development(GO:0060996)
0.0	0.2	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.0	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.3	GO:0018904	glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0	0.1	GO:0042921	glucocorticoid receptor signaling pathway(GO:0042921)
0.0	0.2	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.1	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0	0.2	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.0	GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.1	GO:0060612	adipose tissue development(GO:0060612)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.2	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.1	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.0	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.1	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.1	GO:0032288	myelin assembly(GO:0032288)
0.0	0.2	GO:0048010	vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0	0.1	GO:0051547	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.1	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway(GO:0033144)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.2	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.0	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.0	GO:0007501	mesodermal cell fate specification(GO:0007501)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.0	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.0	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.0	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.0	GO:0010193	response to ozone(GO:0010193)
0.0	0.0	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.0	GO:0031958	corticosteroid receptor signaling pathway(GO:0031958)
0.0	0.1	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.1	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0002070	epithelial cell maturation(GO:0002070)
0.0	0.0	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.0	GO:0048539	bone marrow development(GO:0048539)
0.0	0.0	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.0	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.0	GO:0051459	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.1	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.3	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.0	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.1	GO:0043302	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.0	GO:0000959	mitochondrial RNA metabolic process(GO:0000959) transcription from mitochondrial promoter(GO:0006390)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.0	GO:1903224	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.0	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.1	GO:0015802	basic amino acid transport(GO:0015802)
0.0	0.0	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.2	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.0	GO:0010661	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.1	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.0	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.0	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.0	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.0	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.0	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.0	GO:0048875	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.0	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.0	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.0	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.1	GO:0006853	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.0	GO:0032909	transforming growth factor beta2 production(GO:0032906) regulation of transforming growth factor beta2 production(GO:0032909)
0.0	0.0	GO:0043173	nucleotide salvage(GO:0043173)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0071320	cellular response to cAMP(GO:0071320)
0.0	0.0	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.0	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.0	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.0	GO:0003321	positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0	0.0	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.0	GO:0032226	positive regulation of synaptic transmission, dopaminergic(GO:0032226)
0.0	0.0	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.0	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.2	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.0	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.0	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.0	GO:0071034	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.0	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.0	GO:0051447	negative regulation of meiotic cell cycle(GO:0051447)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.0	GO:0021591	ventricular system development(GO:0021591)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.2	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.1	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.3	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0032449	CBM complex(GO:0032449)
0.0	0.3	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.4	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0036126	outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.2	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.2	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.0	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.3	GO:0032420	stereocilium(GO:0032420)
0.0	0.1	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	0.1	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.0	0.0	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.0	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0005581	collagen trimer(GO:0005581)
0.0	0.1	GO:0001950	obsolete plasma membrane enriched fraction(GO:0001950)
0.0	0.5	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0	0.0	GO:0043205	fibril(GO:0043205)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.0	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0031430	M band(GO:0031430)
0.0	0.0	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.1	GO:0043256	laminin complex(GO:0043256)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.3	GO:0051637	obsolete Gram-positive bacterial cell surface binding(GO:0051637)
0.1	0.5	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.1	0.2	GO:0042577	lipid phosphatase activity(GO:0042577)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.2	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.1	0.2	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.2	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.2	GO:1901567	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.2	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.1	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.2	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.2	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.4	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.2	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.2	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.2	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.2	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.4	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0032052	bile acid binding(GO:0032052)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.3	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.2	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.2	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.2	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.3	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.0	GO:0022821	potassium ion antiporter activity(GO:0022821)
0.0	0.7	GO:0005518	collagen binding(GO:0005518)
0.0	0.4	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.2	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.0	GO:0050543	icosatetraenoic acid binding(GO:0050543)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.1	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.2	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.8	GO:0008009	chemokine activity(GO:0008009)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.2	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.0	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.0	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.1	GO:0005123	death receptor binding(GO:0005123)
0.0	0.0	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.0	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.0	GO:0032296	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.0	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.2	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.0	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.3	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.1	GO:0004339	glucan 1,4-alpha-glucosidase activity(GO:0004339)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.0	0.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0	0.0	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.0	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.1	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.0	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.0	GO:0030354	melanin-concentrating hormone activity(GO:0030354)
0.0	0.0	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.0	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.0	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	0.0	GO:0051636	obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0	0.2	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.2	GO:0030971	receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0	0.0	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0004945	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	1.2	NABA COLLAGENS	Genes encoding collagen proteins
0.0	0.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.1	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.0	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.3	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.1	0.6	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	0.1	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0	0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B
0.0	0.8	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.0	REACTOME BILE ACID AND BILE SALT METABOLISM	Genes involved in Bile acid and bile salt metabolism
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	1.3	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.2	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.2	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.3	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.0	0.0	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.0	0.0	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.0	0.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.2	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.2	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0	0.1	REACTOME SIGNALING BY WNT	Genes involved in Signaling by Wnt
0.0	0.1	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
0.0	0.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.1	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.1	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.0	0.0	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.0	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6