CREMA results: SOX30

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Transcription factors associated with SOX30

Gene Symbol	Gene ID	Gene Info
SOX30 Ensembl NCBI GeneCards UniProt	ENSG00000039600.6	SRY-box transcription factor 30

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr5_157052553_157052704	SOX30	26744	0.125681	0.51	1.6e-01	Click!
chr5_157078532_157078683	SOX30	765	0.594163	-0.72	3.0e-02	Click!
chr5_157079040_157079577	SOX30	64	0.967263	-0.54	1.4e-01	Click!
chr5_157097501_157097703	SOX30	886	0.374265	-0.39	3.0e-01	Click!
chr5_157097815_157098093	SOX30	534	0.468402	-0.78	1.3e-02	Click!

Showing 1 to 5 of 5 entries

Activity of the SOX30 motif across conditions

Conditions sorted by the z-value of the SOX30 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr14_73881929_73882217	0.50	NUMB	numb homolog (Drosophila)	5294	0.21
chr5_157940542_157940882	0.47	CTD-2363C16.1		469302	0.01
chr3_37534685_37535118	0.39	ITGA9	integrin, alpha 9	41291	0.16
chr4_72242987_72243266	0.39	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	38356	0.23
chr7_93672513_93672664	0.38	BET1	Bet1 golgi vesicular membrane trafficking protein	38894	0.18
chr8_40602876_40603064	0.37	ZMAT4	zinc finger, matrin-type 4	143094	0.05
chr4_86713976_86714229	0.36	ARHGAP24	Rho GTPase activating protein 24	14243	0.26
chr20_48831535_48832061	0.35	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	24422	0.19
chr12_75840456_75840607	0.34	GLIPR1	GLI pathogenesis-related 1	33929	0.14
chr10_64876110_64876261	0.34	ENSG00000199446	.	6286	0.2

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX30

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.3	GO:0048149	behavioral response to ethanol(GO:0048149)
0.1	0.3	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.3	GO:0046329	negative regulation of JNK cascade(GO:0046329)
0.0	0.3	GO:0030199	collagen fibril organization(GO:0030199)
0.1	0.2	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	0.2	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.2	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.2	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.2	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)

Showing 1 to 10 of 124 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.3	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.3	GO:0008305	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1	0.2	GO:0043259	laminin-10 complex(GO:0043259)
0.1	0.2	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)

Showing 1 to 10 of 30 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	GO:0005518	collagen binding(GO:0005518)
0.1	0.3	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.3	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.3	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.2	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.2	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.2	GO:0004890	GABA-A receptor activity(GO:0004890)

Showing 1 to 10 of 75 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.8	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.3	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	PID IFNG PATHWAY	IFN-gamma pathway
0.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network

Showing 1 to 6 of 6 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.7	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.3	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions

Showing 1 to 10 of 22 entries

Results for SOX30

Z-value: 1.05

Motif logo

Transcription factors associated with SOX30

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the SOX30 motif across conditions

Conditions sorted by the z-value of the SOX30 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX30

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: