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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SREBF1_TFE3

Z-value: 1.94

Motif logo

Transcription factors associated with SREBF1_TFE3

Gene Symbol	Gene ID	Gene Info
SREBF1 Ensembl NCBI GeneCards UniProt	ENSG00000072310.12	SREBF1
TFE3 Ensembl NCBI GeneCards UniProt	ENSG00000068323.12	TFE3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SREBF1	chr17_17735732_17735883	4324	0.158490	-0.76	1.9e-02	Click!
SREBF1	chr17_17726338_17726662	432	0.764174	-0.64	6.1e-02	Click!
SREBF1	chr17_17725734_17725993	1069	0.410604	-0.58	9.9e-02	Click!
SREBF1	chr17_17750994_17751145	10744	0.140560	-0.57	1.1e-01	Click!
SREBF1	chr17_17729700_17730270	3053	0.179127	-0.53	1.4e-01	Click!
TFE3	chrX_48901466_48901760	601	0.544284	-0.81	8.2e-03	Click!
TFE3	chrX_48897677_48898296	3026	0.124096	-0.55	1.3e-01	Click!
TFE3	chrX_48891131_48891356	9769	0.089268	0.54	1.4e-01	Click!
TFE3	chrX_48899595_48899892	1269	0.262078	-0.50	1.8e-01	Click!
TFE3	chrX_48899000_48899151	1937	0.172082	-0.45	2.2e-01	Click!

Activity of the SREBF1_TFE3 motif across conditions

Conditions sorted by the z-value of the SREBF1_TFE3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_114280229_114280380	1.37	ATP4B	ATPase, H+/K+ exchanging, beta polypeptide	32197	0.15
chr13_114280008_114280159	1.13	ATP4B	ATPase, H+/K+ exchanging, beta polypeptide	32418	0.15
chr16_88999792_89000220	0.68	RP11-830F9.7		4158	0.14
chr17_80406015_80406483	0.57	C17orf62	chromosome 17 open reading frame 62	1232	0.26
chr12_1921271_1921442	0.54	CACNA2D4	calcium channel, voltage-dependent, alpha 2/delta subunit 4	399	0.86
chr17_9160012_9160446	0.54	RP11-85B7.4		26262	0.21
chr7_120633768_120634071	0.47	CPED1	cadherin-like and PC-esterase domain containing 1	4243	0.23
chr17_74523485_74524063	0.46	CYGB	cytoglobin	4373	0.1
chr5_172223282_172223574	0.46	ENSG00000206741	.	16331	0.14
chr13_111837384_111838319	0.44	ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	566	0.79
chr8_72760922_72761073	0.43	MSC	musculin	4294	0.2
chr18_22864021_22864172	0.43	CTD-2006O16.2		17994	0.26
chr16_27771158_27771442	0.42	ENSG00000201371	.	37587	0.15
chr6_157400383_157400625	0.41	RP1-137K2.2		40336	0.2
chr10_49664157_49664685	0.41	ARHGAP22	Rho GTPase activating protein 22	4751	0.27
chr12_78450993_78451144	0.40	RP11-136F16.1		34449	0.22
chr21_47479982_47480133	0.40	AP001471.1		37387	0.12
chr5_168974560_168974711	0.39	ENSG00000206614	.	4818	0.28
chr12_63155759_63156101	0.39	ENSG00000200296	.	88751	0.08
chr10_536188_536339	0.39	RP11-490E15.2		52762	0.13
chrX_41157450_41157601	0.39	ENSG00000199564	.	5474	0.19
chr1_61637743_61637894	0.39	RP4-802A10.1		47413	0.17
chr10_50348746_50348897	0.38	FAM170B-AS1	FAM170B antisense RNA 1	3281	0.21
chr5_179246518_179247261	0.38	SQSTM1	sequestosome 1	870	0.42
chr7_42377268_42377419	0.38	GLI3	GLI family zinc finger 3	100685	0.09
chr14_51886452_51886750	0.36	FRMD6	FERM domain containing 6	69254	0.11
chr1_231013412_231013563	0.36	RP5-858B6.3		2895	0.17
chr8_144487498_144487649	0.36	RP11-909N17.2		7346	0.11
chr3_113473365_113473635	0.36	ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	7603	0.19
chr8_91554994_91555145	0.36	ENSG00000199354	.	31713	0.2
chr2_102079958_102080109	0.36	RFX8	RFX family member 8, lacking RFX DNA binding domain	10704	0.26
chr7_73868587_73869056	0.35	GTF2IRD1	GTF2I repeat domain containing 1	382	0.88
chr13_78407829_78407993	0.35	EDNRB	endothelin receptor type B	85034	0.08
chr11_70261652_70262194	0.35	CTTN	cortactin	4308	0.17
chr11_69263417_69264003	0.35	CCND1	cyclin D1	192145	0.03
chr6_132075002_132075153	0.35	ENSG00000266807	.	38235	0.12
chr9_126089014_126089214	0.34	CRB2	crumbs homolog 2 (Drosophila)	29335	0.19
chr18_10059619_10060204	0.34	ENSG00000263630	.	54717	0.15
chr21_43560423_43560574	0.34	C21orf128	chromosome 21 open reading frame 128	31854	0.15
chr9_90134401_90134552	0.34	DAPK1	death-associated protein kinase 1	20556	0.22
chr1_68805468_68805619	0.33	WLS	wntless Wnt ligand secretion mediator	106740	0.06
chr2_70256822_70257044	0.33	PCBP1-AS1	PCBP1 antisense RNA 1	17585	0.16
chr10_102669234_102669601	0.33	ENSG00000222072	.	2380	0.18
chr3_177499563_177499874	0.33	ENSG00000200288	.	157521	0.04
chr13_21620980_21621217	0.33	ENSG00000201821	.	8292	0.15
chr4_77485152_77485314	0.33	ENSG00000263445	.	9488	0.17
chr3_8499776_8500071	0.33	LMCD1-AS1	LMCD1 antisense RNA 1 (head to head)	43361	0.15
chr1_240473113_240473392	0.33	ENSG00000252317	.	31433	0.19
chr5_53810354_53810505	0.33	SNX18	sorting nexin 18	3160	0.35
chr3_52315744_52316277	0.32	WDR82	WD repeat domain 82	3351	0.11
chr11_61066465_61066743	0.32	VWCE	von Willebrand factor C and EGF domains	3708	0.15
chr6_35393359_35394053	0.32	FANCE	Fanconi anemia, complementation group E	26432	0.15
chr2_101507765_101507916	0.32	NPAS2	neuronal PAS domain protein 2	33768	0.17
chr8_95047336_95047487	0.31	ENSG00000263855	.	61329	0.13
chr7_72838277_72838494	0.31	FZD9	frizzled family receptor 9	9724	0.16
chr16_24483163_24483314	0.31	ENSG00000264465	.	32929	0.19
chr4_40890014_40890165	0.31	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	2353	0.3
chr18_2980168_2980882	0.31	LPIN2	lipin 2	2346	0.24
chr5_55366488_55367129	0.31	ANKRD55	ankyrin repeat domain 55	45970	0.11
chr2_144474226_144474407	0.31	RP11-434H14.1		24547	0.2
chr12_110386988_110387317	0.31	GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	46877	0.1
chr1_856648_857113	0.31	SAMD11	sterile alpha motif domain containing 11	3380	0.14
chr12_7063873_7064421	0.31	PTPN6	protein tyrosine phosphatase, non-receptor type 6	3609	0.07
chr10_104408471_104409659	0.31	TRIM8	tripartite motif containing 8	4421	0.2
chr8_59067361_59067643	0.30	FAM110B	family with sequence similarity 110, member B	160389	0.04
chr16_75059862_75060029	0.30	ZNRF1	zinc and ring finger 1, E3 ubiquitin protein ligase	23750	0.17
chr12_25064548_25064743	0.30	BCAT1	branched chain amino-acid transaminase 1, cytosolic	8636	0.18
chr20_38477946_38478097	0.30	ENSG00000263518	.	253977	0.02
chr22_24540306_24540599	0.30	CABIN1	calcineurin binding protein 1	11354	0.17
chr11_67070127_67070757	0.30	SSH3	slingshot protein phosphatase 3	477	0.67
chr5_33276862_33277013	0.30	CTD-2203K17.1		163788	0.04
chr1_183779354_183779505	0.30	RGL1	ral guanine nucleotide dissociation stimulator-like 1	5139	0.28
chr6_43958464_43958740	0.30	C6orf223	chromosome 6 open reading frame 223	9715	0.17
chr3_5051196_5051347	0.30	BHLHE40-AS1	BHLHE40 antisense RNA 1	29625	0.16
chr1_162679808_162679959	0.30	DDR2	discoidin domain receptor tyrosine kinase 2	57144	0.11
chr9_127047195_127047346	0.29	NEK6	NIMA-related kinase 6	1449	0.4
chr22_45094354_45094632	0.29	PRR5	proline rich 5 (renal)	3585	0.21
chr5_38796861_38797012	0.29	RP11-122C5.3		13254	0.25
chr12_105621275_105621485	0.29	APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	2258	0.35
chr8_97594056_97594225	0.29	SDC2	syndecan 2	1563	0.51
chr19_18980510_18980983	0.29	AC005197.2		11743	0.11
chr19_12885878_12886253	0.29	HOOK2	hook microtubule-tethering protein 2	272	0.76
chr5_67279817_67279968	0.29	ENSG00000223149	.	16619	0.29
chr17_41546663_41546814	0.29	ENSG00000252729	.	4215	0.14
chr17_73061461_73061965	0.29	KCTD2	potassium channel tetramerization domain containing 2	18373	0.07
chr2_106510978_106511129	0.29	AC009505.2		37420	0.18
chr6_108892078_108892352	0.29	FOXO3	forkhead box O3	10146	0.29
chr5_167364874_167365025	0.28	CTC-353G13.1		15525	0.19
chr1_162698483_162698634	0.28	DDR2	discoidin domain receptor tyrosine kinase 2	38469	0.15
chr12_112043846_112043997	0.28	ATXN2	ataxin 2	6441	0.18
chr11_3159025_3159707	0.28	OSBPL5	oxysterol binding protein-like 5	8807	0.17
chr19_13318401_13318895	0.28	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	49566	0.08
chr8_99410270_99410421	0.28	KCNS2	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	28905	0.17
chr1_54199103_54199254	0.28	GLIS1	GLIS family zinc finger 1	699	0.69
chr2_158648940_158649091	0.28	ACVR1	activin A receptor, type I	14493	0.23
chr16_24786805_24787030	0.28	TNRC6A	trinucleotide repeat containing 6A	15891	0.22
chr18_43952493_43952644	0.28	RNF165	ring finger protein 165	38381	0.2
chr2_242824328_242824697	0.28	AC131097.3		413	0.76
chr19_12901212_12902001	0.28	JUNB	jun B proto-oncogene	704	0.38
chr4_86680728_86680879	0.28	ARHGAP24	Rho GTPase activating protein 24	19056	0.23
chr13_24607809_24608008	0.27	SPATA13	spermatogenesis associated 13	53964	0.13
chr1_94929133_94929319	0.27	ABCD3	ATP-binding cassette, sub-family D (ALD), member 3	45191	0.17
chr2_40266109_40266315	0.27	SLC8A1-AS1	SLC8A1 antisense RNA 1	3278	0.4
chr8_18825289_18825440	0.27	ENSG00000201157	.	11765	0.21
chr14_75754946_75755194	0.27	FOS	FBJ murine osteosarcoma viral oncogene homolog	8174	0.17
chr15_57612815_57613005	0.27	TCF12	transcription factor 12	38257	0.16
chr6_108019813_108020038	0.27	SCML4	sex comb on midleg-like 4 (Drosophila)	33674	0.22
chr18_22878825_22879093	0.27	CTD-2006O16.2		3131	0.37
chr1_206751930_206752246	0.27	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	21595	0.14
chr20_56050830_56050981	0.27	CTCFL	CCCTC-binding factor (zinc finger protein)-like	48408	0.12
chr2_145263610_145263985	0.27	ZEB2	zinc finger E-box binding homeobox 2	11318	0.24
chr10_115032323_115032584	0.27	ENSG00000238380	.	80731	0.11
chr5_371573_371933	0.27	AHRR	aryl-hydrocarbon receptor repressor	28110	0.15
chr7_2430326_2430573	0.27	CHST12	carbohydrate (chondroitin 4) sulfotransferase 12	12774	0.18
chr16_73249648_73249935	0.27	C16orf47	chromosome 16 open reading frame 47	71445	0.13
chr16_70737707_70738175	0.27	VAC14	Vac14 homolog (S. cerevisiae)	3793	0.18
chr18_43168412_43168563	0.27	SLC14A2	solute carrier family 14 (urea transporter), member 2	26279	0.19
chr11_3072971_3073291	0.27	ENSG00000201616	.	3380	0.17
chr3_148426073_148426436	0.27	AGTR1	angiotensin II receptor, type 1	10549	0.28
chr22_43413635_43413786	0.27	PACSIN2	protein kinase C and casein kinase substrate in neurons 2	2559	0.28
chr3_157051821_157052175	0.27	ENSG00000243176	.	48049	0.16
chr10_71721356_71721785	0.26	COL13A1	collagen, type XIII, alpha 1	31361	0.19
chr11_122552093_122552778	0.26	UBASH3B	ubiquitin associated and SH3 domain containing B	26052	0.2
chr9_18947881_18948032	0.26	FAM154A	family with sequence similarity 154, member A	85230	0.07
chr17_76312953_76313854	0.26	SOCS3	suppressor of cytokine signaling 3	42752	0.1
chr5_131007765_131007916	0.26	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	36911	0.2
chr18_10290931_10291168	0.26	ENSG00000239031	.	98948	0.08
chr4_109909097_109909248	0.26	COL25A1	collagen, type XXV, alpha 1	163797	0.04
chr1_27341879_27342049	0.26	FAM46B	family with sequence similarity 46, member B	2637	0.24
chr11_61732166_61732317	0.26	FTH1	ferritin, heavy polypeptide 1	2397	0.19
chr8_6149074_6149420	0.26	RP11-115C21.2		114816	0.06
chr3_12345477_12345742	0.26	PPARG	peroxisome proliferator-activated receptor gamma	1663	0.5
chr16_29167036_29167187	0.26	CTB-134H23.3		48345	0.11
chr12_67753116_67753506	0.26	CAND1	cullin-associated and neddylation-dissociated 1	60559	0.16
chr6_36885867_36886018	0.26	C6orf89	chromosome 6 open reading frame 89	32302	0.13
chr11_327286_327556	0.26	IFITM3	interferon induced transmembrane protein 3	116	0.9
chr8_123671514_123671802	0.26	ENSG00000238901	.	11872	0.28
chr1_183008429_183008580	0.26	LAMC1	laminin, gamma 1 (formerly LAMB2)	15909	0.2
chr12_2404530_2404681	0.26	CACNA1C-IT3	CACNA1C intronic transcript 3 (non-protein coding)	25663	0.23
chr15_101995616_101995767	0.26	PCSK6	proprotein convertase subtilisin/kexin type 6	11823	0.25
chr4_169614541_169614692	0.26	ENSG00000206613	.	6749	0.22
chr1_110367063_110367374	0.25	EPS8L3	EPS8-like 3	60569	0.08
chr6_15951266_15951417	0.25	MYLIP	myosin regulatory light chain interacting protein	178015	0.03
chr12_52596781_52596986	0.25	KRT80	keratin 80	11099	0.12
chr4_4764465_4765054	0.25	MSX1	msh homeobox 1	96634	0.08
chr20_43332745_43332896	0.25	RP11-445H22.3		8083	0.13
chr18_53815316_53815517	0.25	ENSG00000201816	.	68591	0.14
chr6_41692581_41692751	0.25	TFEB	transcription factor EB	1202	0.34
chr1_101050092_101050243	0.25	GPR88	G protein-coupled receptor 88	46474	0.16
chr5_111089942_111090243	0.25	NREP	neuronal regeneration related protein	1856	0.38
chr12_54088723_54089454	0.25	ATP5G2	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)	17906	0.15
chr1_41273041_41273192	0.25	ENSG00000264582	.	2598	0.21
chr15_69590837_69591193	0.25	ENSG00000261634	.	82	0.74
chr4_5748628_5748779	0.25	EVC	Ellis van Creveld syndrome	35761	0.18
chr17_67056041_67056192	0.25	ABCA9	ATP-binding cassette, sub-family A (ABC1), member 9	931	0.6
chr11_47628746_47628950	0.25	ENSG00000223187	.	7698	0.09
chr11_27140730_27140881	0.25	BBOX1	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	64041	0.13
chr16_49653577_49653728	0.25	ZNF423	zinc finger protein 423	21111	0.24
chr7_5719485_5719675	0.25	RNF216-IT1	RNF216 intronic transcript 1 (non-protein coding)	512	0.81
chr9_140341647_140341798	0.25	ENTPD8	ectonucleoside triphosphate diphosphohydrolase 8	5821	0.12
chr9_137366473_137366866	0.25	RXRA	retinoid X receptor, alpha	68241	0.11
chr2_114519255_114519406	0.25	SLC35F5	solute carrier family 35, member F5	4930	0.23
chr3_171792488_171792655	0.24	FNDC3B	fibronectin type III domain containing 3B	27868	0.24
chr11_46302438_46302589	0.24	CREB3L1	cAMP responsive element binding protein 3-like 1	3285	0.22
chr6_161648518_161648669	0.24	AGPAT4	1-acylglycerol-3-phosphate O-acyltransferase 4	46458	0.2
chr20_4795714_4796665	0.24	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	420	0.85
chr10_81160624_81160775	0.24	RP11-342M3.5		18615	0.19
chr10_129706485_129706650	0.24	PTPRE	protein tyrosine phosphatase, receptor type, E	1151	0.53
chr7_151453060_151453479	0.24	PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	19869	0.2
chr18_52454307_52454540	0.24	RAB27B	RAB27B, member RAS oncogene family	41007	0.2
chr2_190017171_190017322	0.24	ENSG00000264725	.	19409	0.19
chr17_32563089_32563474	0.24	CCL2	chemokine (C-C motif) ligand 2	19023	0.12
chr4_176974099_176974250	0.24	WDR17	WD repeat domain 17	12811	0.18
chr9_95027177_95027328	0.24	IARS	isoleucyl-tRNA synthetase	19869	0.16
chr17_29911685_29911952	0.24	ENSG00000199187	.	9388	0.12
chr10_60766507_60766658	0.24	ENSG00000252076	.	137638	0.05
chr11_326229_326864	0.24	IFITM3	interferon induced transmembrane protein 3	991	0.28
chr21_37153447_37153598	0.24	ENSG00000211590	.	60509	0.14
chr17_74526963_74527181	0.24	CYGB	cytoglobin	1075	0.29
chr6_157469967_157470240	0.24	ARID1B	AT rich interactive domain 1B (SWI1-like)	58	0.98
chr12_49630269_49630420	0.24	TUBA1C	tubulin, alpha 1c	8635	0.12
chr18_74199081_74199269	0.24	ZNF516	zinc finger protein 516	3560	0.21
chr12_53683498_53683649	0.24	PFDN5	prefoldin subunit 5	5502	0.11
chr3_4263985_4264136	0.24	SETMAR	SET domain and mariner transposase fusion gene	80928	0.11
chr19_45268285_45268794	0.23	ENSG00000253027	.	332	0.8
chr18_20808297_20808526	0.23	RP11-17J14.2		31907	0.19
chr1_3691739_3692479	0.23	SMIM1	small integral membrane protein 1 (Vel blood group)	2482	0.16
chr22_43039017_43039428	0.23	CYB5R3	cytochrome b5 reductase 3	1293	0.31
chr8_116430587_116430872	0.23	TRPS1	trichorhinophalangeal syndrome I	73719	0.12
chr12_80288703_80288854	0.23	ENSG00000201942	.	16579	0.17
chr19_1361317_1362052	0.23	MUM1	melanoma associated antigen (mutated) 1	5321	0.1
chr5_154034007_154034158	0.23	ENSG00000221552	.	31254	0.14
chr2_200169829_200169980	0.23	RP11-486F17.1		20129	0.27
chr18_335808_335975	0.23	THOC1	THO complex 1	67864	0.11
chr14_75016499_75016650	0.23	LTBP2	latent transforming growth factor beta binding protein 2	40064	0.12
chr10_73381093_73381244	0.23	CDH23	cadherin-related 23	24505	0.22
chr10_29824648_29824978	0.23	ENSG00000207612	.	9213	0.19
chr3_168823031_168823291	0.23	MECOM	MDS1 and EVI1 complex locus	22661	0.28
chr8_56832033_56832524	0.23	ENSG00000216204	.	10758	0.14
chr11_70172757_70172923	0.23	CTA-797E19.2		475	0.71

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF1_TFE3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1	0.3	GO:0035583	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.4	GO:0043615	astrocyte cell migration(GO:0043615)
0.1	0.3	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.1	0.2	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.1	0.2	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.1	0.3	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.1	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.1	0.5	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1	0.2	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.1	0.2	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1	0.2	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.1	0.3	GO:0007028	cytoplasm organization(GO:0007028)
0.1	0.2	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.1	0.3	GO:0016056	rhodopsin mediated signaling pathway(GO:0016056)
0.1	0.2	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1	0.3	GO:0060155	platelet dense granule organization(GO:0060155)
0.1	0.2	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.1	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1	0.2	GO:0071731	response to nitric oxide(GO:0071731)
0.1	0.3	GO:0035929	steroid hormone secretion(GO:0035929)
0.1	0.3	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1	0.2	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.1	0.1	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.0	GO:0043129	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.0	GO:0021955	central nervous system neuron axonogenesis(GO:0021955)
0.0	0.4	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.2	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.1	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.2	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:1903224	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.2	GO:0015705	iodide transport(GO:0015705)
0.0	0.1	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.2	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.2	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.5	GO:0048844	artery morphogenesis(GO:0048844)
0.0	0.1	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.2	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.2	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.1	GO:0022030	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.2	GO:0031000	response to caffeine(GO:0031000)
0.0	0.1	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.0	GO:0061526	acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) acetylcholine secretion(GO:0061526)
0.0	0.0	GO:0031223	auditory behavior(GO:0031223)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.1	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.2	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.1	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.2	GO:0008228	opsonization(GO:0008228)
0.0	0.1	GO:0048643	positive regulation of skeletal muscle tissue development(GO:0048643)
0.0	0.1	GO:0016265	obsolete death(GO:0016265)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.1	GO:0097531	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.1	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.1	GO:0071294	cellular response to zinc ion(GO:0071294)
0.0	0.1	GO:1903115	regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.0	0.1	GO:0033591	response to L-ascorbic acid(GO:0033591)
0.0	0.1	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.1	GO:0016103	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.0	GO:2000644	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0032354	response to follicle-stimulating hormone(GO:0032354)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.0	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0	0.0	GO:2000542	negative regulation of gastrulation(GO:2000542)
0.0	0.0	GO:0002885	positive regulation of hypersensitivity(GO:0002885)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.2	GO:0044872	lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.0	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.2	GO:0032332	positive regulation of chondrocyte differentiation(GO:0032332)
0.0	0.0	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0006658	phosphatidylserine metabolic process(GO:0006658)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.2	GO:1902603	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.0	GO:0021834	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.0	0.2	GO:0043030	regulation of macrophage activation(GO:0043030)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.4	GO:0048286	lung alveolus development(GO:0048286)
0.0	0.2	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.0	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.5	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.1	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.0	GO:0048245	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.2	GO:0050926	regulation of positive chemotaxis(GO:0050926)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.0	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0	0.1	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.0	0.1	GO:0007549	dosage compensation(GO:0007549)
0.0	0.0	GO:0015868	purine ribonucleotide transport(GO:0015868)
0.0	0.1	GO:1902743	regulation of lamellipodium organization(GO:1902743)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.1	GO:0046487	glyoxylate metabolic process(GO:0046487)
0.0	0.0	GO:0021831	embryonic olfactory bulb interneuron precursor migration(GO:0021831)
0.0	0.0	GO:0003148	outflow tract septum morphogenesis(GO:0003148)
0.0	0.1	GO:0009169	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.0	GO:0046639	negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0	0.1	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.1	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.0	GO:1904063	negative regulation of calcium ion import(GO:0090281) negative regulation of cation transmembrane transport(GO:1904063)
0.0	0.0	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.0	GO:0033023	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.4	GO:0001755	neural crest cell migration(GO:0001755)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0002858	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.1	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.0	0.1	GO:0001967	suckling behavior(GO:0001967)
0.0	0.0	GO:0033622	integrin activation(GO:0033622)
0.0	0.1	GO:0033235	positive regulation of protein sumoylation(GO:0033235)
0.0	0.0	GO:0032413	negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0	0.0	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:0071830	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0	0.0	GO:0006663	platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.2	GO:0034605	cellular response to heat(GO:0034605)
0.0	0.0	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.0	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.1	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.2	GO:0002021	response to dietary excess(GO:0002021)
0.0	0.0	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.1	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.0	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0002040	sprouting angiogenesis(GO:0002040)
0.0	0.1	GO:0033598	mammary gland epithelial cell proliferation(GO:0033598)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:0006582	melanin metabolic process(GO:0006582)
0.0	0.0	GO:0060677	ureteric bud elongation(GO:0060677)
0.0	0.2	GO:0009409	response to cold(GO:0009409)
0.0	0.0	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.0	GO:0060527	prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0	0.1	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.1	GO:0055075	potassium ion homeostasis(GO:0055075)
0.0	0.0	GO:0070244	negative regulation of thymocyte apoptotic process(GO:0070244)
0.0	0.0	GO:1904251	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0	0.1	GO:0006893	Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.0	GO:0045064	T-helper 2 cell differentiation(GO:0045064)
0.0	0.0	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.0	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0051818	disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.0	0.0	GO:0048853	forebrain morphogenesis(GO:0048853)
0.0	0.0	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.1	GO:0006896	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.0	GO:0015879	amino-acid betaine transport(GO:0015838) carnitine transport(GO:0015879)
0.0	0.0	GO:0070272	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.0	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.0	GO:0006530	asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0	0.0	GO:0021891	olfactory bulb interneuron differentiation(GO:0021889) olfactory bulb interneuron development(GO:0021891)
0.0	0.1	GO:0016556	mRNA modification(GO:0016556)
0.0	0.2	GO:0006085	acetyl-CoA biosynthetic process(GO:0006085)
0.0	0.0	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.0	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.0	GO:0001993	regulation of systemic arterial blood pressure by norepinephrine-epinephrine(GO:0001993)
0.0	0.0	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.2	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.0	GO:0070498	interleukin-1-mediated signaling pathway(GO:0070498)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0001554	luteolysis(GO:0001554)
0.0	0.0	GO:0045410	positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0	0.0	GO:0014850	response to muscle activity(GO:0014850)
0.0	0.0	GO:0070092	glucagon secretion(GO:0070091) regulation of glucagon secretion(GO:0070092)
0.0	0.0	GO:0030952	establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0	0.1	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	0.2	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.2	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.3	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.3	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.2	GO:0070083	clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.2	GO:0031082	BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0	0.3	GO:0098651	basement membrane collagen trimer(GO:0098651)
0.0	0.2	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.2	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.2	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.1	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.2	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0042599	lamellar body(GO:0042599)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.1	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	0.2	GO:0098644	complex of collagen trimers(GO:0098644)
0.0	0.1	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.0	GO:0000805	X chromosome(GO:0000805)
0.0	1.7	GO:0005925	focal adhesion(GO:0005925)
0.0	0.0	GO:0042824	MHC class I peptide loading complex(GO:0042824)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.0	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.1	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0043205	fibril(GO:0043205)
0.0	0.6	GO:0005604	basement membrane(GO:0005604)
0.0	0.0	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.1	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	0.1	GO:0002102	podosome(GO:0002102)
0.0	0.0	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.0	GO:0002141	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	0.3	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.1	0.3	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1	0.5	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.1	0.1	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.1	0.2	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.4	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	0.3	GO:0050542	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.1	0.2	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.2	GO:0001849	complement component C1q binding(GO:0001849)
0.1	0.4	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.1	0.2	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.1	0.2	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1	0.3	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.2	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.5	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.4	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0046980	tapasin binding(GO:0046980)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.3	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.2	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.3	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.2	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.2	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.2	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.2	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.2	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.1	GO:0004083	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.1	GO:0016215	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.1	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.3	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0	0.1	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.4	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	1.5	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.4	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.1	GO:0051636	obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0	0.0	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.0	GO:0050543	icosatetraenoic acid binding(GO:0050543)
0.0	0.4	GO:1901682	sulfur compound transmembrane transporter activity(GO:1901682)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.1	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.1	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.0	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.0	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.1	GO:0005112	Notch binding(GO:0005112)
0.0	0.1	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345)
0.0	0.1	GO:0004945	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.0	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.0	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.0	GO:0004739	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.3	GO:0017147	Wnt-protein binding(GO:0017147)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.2	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.0	GO:0015226	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.2	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0	0.0	GO:0004803	transposase activity(GO:0004803)
0.0	0.1	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.0	GO:0005113	patched binding(GO:0005113)
0.0	0.0	GO:0004802	transketolase activity(GO:0004802)
0.0	0.1	GO:0015245	fatty acid transporter activity(GO:0015245)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.2	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.0	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.5	GO:0008009	chemokine activity(GO:0008009)
0.0	0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.0	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.0	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0030553	cGMP binding(GO:0030553)
0.0	0.0	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.1	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.0	GO:0046977	TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.1	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.2	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.0	0.1	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.1	GO:0022821	potassium ion antiporter activity(GO:0022821)
0.0	0.1	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.1	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.0	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.2	GO:1990782	receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID REELIN PATHWAY	Reelin signaling pathway
0.0	0.6	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.1	PID INSULIN PATHWAY	Insulin Pathway
0.0	1.3	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.1	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.0	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	0.1	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.0	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.0	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.3	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.4	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	0.0	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.0	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	0.0	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.3	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.2	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
1.0	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.4	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.3	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.2	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.5	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.3	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	REACTOME GABA B RECEPTOR ACTIVATION	Genes involved in GABA B receptor activation
0.2	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0	REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	Genes involved in MAP kinase activation in TLR cascade
0.1	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.1	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.2	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.2	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.1	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
0.1	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.1	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism