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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SREBF2

Z-value: 1.07

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Transcription factors associated with SREBF2

Gene Symbol	Gene ID	Gene Info
SREBF2 Ensembl NCBI GeneCards UniProt	ENSG00000198911.7	SREBF2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SREBF2	chr22_42229661_42229812	627	0.484546	0.67	4.9e-02	Click!
SREBF2	chr22_42228218_42228405	798	0.483410	0.63	7.0e-02	Click!
SREBF2	chr22_42269933_42270084	24672	0.094167	0.54	1.3e-01	Click!
SREBF2	chr22_42226223_42226448	2774	0.168547	0.47	2.0e-01	Click!
SREBF2	chr22_42222831_42222982	6203	0.125767	-0.35	3.5e-01	Click!

Activity of the SREBF2 motif across conditions

Conditions sorted by the z-value of the SREBF2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_92445809_92446274	0.62	GADD45G	growth arrest and DNA-damage-inducible, gamma	226088	0.02
chr3_111851090_111851324	0.56	GCSAM	germinal center-associated, signaling and motility	865	0.43
chr3_195508119_195508270	0.50	MUC4	mucin 4, cell surface associated	30534	0.15
chr21_47036065_47036221	0.50	PCBP3	poly(rC) binding protein 3	27465	0.2
chr3_195506341_195506492	0.48	MUC4	mucin 4, cell surface associated	32312	0.15
chr3_195511774_195511925	0.47	MUC4	mucin 4, cell surface associated	26879	0.16
chr7_1957992_1958143	0.46	MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	22118	0.21
chr13_114909698_114910252	0.46	RASA3	RAS p21 protein activator 3	11889	0.21
chr17_2680360_2680552	0.41	RAP1GAP2	RAP1 GTPase activating protein 2	106	0.96
chr17_65420745_65420896	0.41	ENSG00000201547	.	15823	0.13
chr1_22463906_22464057	0.41	WNT4	wingless-type MMTV integration site family, member 4	5478	0.23
chr13_114873706_114873857	0.40	RASA3-IT1	RASA3 intronic transcript 1 (non-protein coding)	514	0.83
chr22_24037895_24038125	0.39	RGL4	ral guanine nucleotide dissociation stimulator-like 4	661	0.59
chr20_25071203_25071354	0.38	VSX1	visual system homeobox 1	8282	0.21
chr13_114873900_114874051	0.37	RASA3-IT1	RASA3 intronic transcript 1 (non-protein coding)	320	0.91
chr2_95722386_95722537	0.37	AC103563.9		3540	0.21
chr16_66914734_66914885	0.36	PDP2	pyruvate dehyrogenase phosphatase catalytic subunit 2	299	0.82
chr22_21195460_21195707	0.36	PI4KA	phosphatidylinositol 4-kinase, catalytic, alpha	17487	0.13
chr1_118198517_118198668	0.34	ENSG00000212266	.	32772	0.18
chr10_22540636_22540794	0.34	EBLN1	endogenous Bornavirus-like nucleoprotein 1	41765	0.14
chr9_95895847_95895998	0.33	NINJ1	ninjurin 1	648	0.7
chr19_3668661_3668812	0.33	AC004637.1		3844	0.14
chr1_33168985_33169202	0.33	SYNC	syncoilin, intermediate filament protein	104	0.96
chr9_126168451_126168602	0.32	ENSG00000207991	.	3644	0.28
chr20_62178843_62178994	0.32	SRMS	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	61	0.95
chr2_109761328_109761479	0.32	ENSG00000264934	.	3359	0.3
chr20_20350513_20350736	0.32	INSM1	insulinoma-associated 1	1859	0.42
chr3_195507832_195507983	0.31	MUC4	mucin 4, cell surface associated	30821	0.15
chr15_99129470_99129621	0.31	RP11-35O15.1		61055	0.12
chr4_6280365_6280536	0.31	WFS1	Wolfram syndrome 1 (wolframin)	8873	0.27
chr9_95834831_95835050	0.30	SUSD3	sushi domain containing 3	3558	0.21
chr3_195507349_195507500	0.30	MUC4	mucin 4, cell surface associated	31304	0.15
chr13_100034854_100035070	0.30	ENSG00000207719	.	26577	0.18
chr11_112096736_112096896	0.30	PTS	6-pyruvoyltetrahydropterin synthase	272	0.85
chr6_37666582_37666733	0.29	MDGA1	MAM domain containing glycosylphosphatidylinositol anchor 1	425	0.89
chr11_65556019_65556254	0.29	OVOL1-AS1	OVOL1 antisense RNA 1	1210	0.25
chr14_61905397_61905581	0.28	PRKCH	protein kinase C, eta	3787	0.3
chr8_66702583_66702734	0.28	PDE7A	phosphodiesterase 7A	1339	0.55
chr1_91565606_91565979	0.27	ZNF644	zinc finger protein 644	77963	0.12
chr10_11287242_11287547	0.27	RP3-323N1.2		74055	0.1
chr2_9897660_9897811	0.27	ENSG00000200034	.	16823	0.23
chr20_62683213_62683364	0.26	SOX18	SRY (sex determining region Y)-box 18	2294	0.14
chr2_197047764_197047992	0.26	STK17B	serine/threonine kinase 17b	6651	0.2
chr14_99699047_99699313	0.26	AL109767.1		30105	0.18
chr4_6918352_6918503	0.26	TBC1D14	TBC1 domain family, member 14	6452	0.19
chr18_46370124_46370275	0.26	RP11-484L8.1		9058	0.27
chr10_105506823_105507043	0.26	SH3PXD2A	SH3 and PX domains 2A	54003	0.12
chr10_130075967_130076118	0.26	MKI67	marker of proliferation Ki-67	151393	0.04
chr11_66060029_66060180	0.26	TMEM151A	transmembrane protein 151A	763	0.33
chr21_45583294_45583445	0.25	AP001055.1		10211	0.14
chr16_85599289_85599463	0.25	GSE1	Gse1 coiled-coil protein	45639	0.15
chr3_31329622_31329773	0.25	ENSG00000222983	.	59490	0.15
chr9_129481687_129481848	0.25	ENSG00000266403	.	1155	0.56
chr3_5019096_5019422	0.25	BHLHE40	basic helix-loop-helix family, member e40	1542	0.37
chrX_7000781_7000932	0.25	ENSG00000264268	.	65045	0.13
chr4_154573712_154573880	0.25	RP11-153M7.3		25615	0.18
chr15_63895899_63896141	0.24	USP3-AS1	USP3 antisense RNA 1	2232	0.3
chr7_79081789_79081970	0.24	ENSG00000234456	.	319	0.81
chr16_8960877_8961130	0.24	CARHSP1	calcium regulated heat stable protein 1, 24kDa	282	0.84
chr7_76073300_76073451	0.24	ZP3	zona pellucida glycoprotein 3 (sperm receptor)	10588	0.14
chr11_2912733_2913001	0.24	SLC22A18AS	solute carrier family 22 (organic cation transporter), member 18 antisense	2207	0.19
chr1_161039848_161040008	0.24	ARHGAP30	Rho GTPase activating protein 30	168	0.87
chr1_76081137_76081358	0.23	SLC44A5	solute carrier family 44, member 5	4446	0.28
chr9_119465090_119465241	0.23	TRIM32	tripartite motif containing 32	15543	0.22
chr14_68843315_68843480	0.23	RAD51B	RAD51 paralog B	34830	0.22
chr20_31109331_31109482	0.23	C20orf112	chromosome 20 open reading frame 112	749	0.66
chr1_32682080_32682262	0.23	EIF3I	eukaryotic translation initiation factor 3, subunit I	5358	0.08
chr20_36432319_36432470	0.23	CTNNBL1	catenin, beta like 1	26719	0.22
chr16_78782975_78783145	0.23	RP11-319G9.3		148002	0.04
chr4_99919820_99919971	0.23	ENSG00000265213	.	1357	0.36
chr1_43398814_43399160	0.23	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	2191	0.3
chr12_6570561_6570923	0.23	VAMP1	vesicle-associated membrane protein 1 (synaptobrevin 1)	9069	0.09
chr11_44326954_44327198	0.22	ALX4	ALX homeobox 4	4640	0.33
chr16_56691235_56691435	0.22	MT1F	metallothionein 1F	271	0.77
chr14_77334150_77334556	0.22	ENSG00000223174	.	22253	0.17
chr18_53254709_53254980	0.22	TCF4	transcription factor 4	497	0.87
chrX_119592645_119592909	0.22	LAMP2	lysosomal-associated membrane protein 2	10070	0.23
chr7_2750332_2750483	0.22	AMZ1	archaelysin family metallopeptidase 1	22571	0.19
chr13_40779803_40779954	0.22	ENSG00000207458	.	21086	0.28
chr1_200515720_200515871	0.22	KIF14	kinesin family member 14	74067	0.11
chr1_203596210_203596415	0.22	ATP2B4	ATPase, Ca++ transporting, plasma membrane 4	384	0.9
chr4_3303410_3303667	0.21	RGS12	regulator of G-protein signaling 12	7224	0.25
chr18_5417488_5417739	0.21	EPB41L3	erythrocyte membrane protein band 4.1-like 3	2187	0.38
chr15_42124634_42124785	0.21	JMJD7-PLA2G4B	JMJD7-PLA2G4B readthrough	4394	0.11
chr11_1800747_1800898	0.21	CTSD	cathepsin D	15600	0.08
chr16_2198362_2198540	0.21	RAB26	RAB26, member RAS oncogene family	174	0.83
chr21_45341659_45341920	0.21	ENSG00000199598	.	2007	0.29
chr4_146100468_146100690	0.21	OTUD4	OTU domain containing 4	184	0.96
chr3_4864499_4864721	0.21	ENSG00000239126	.	55776	0.13
chr17_80188379_80188575	0.21	SLC16A3	solute carrier family 16 (monocarboxylate transporter), member 3	1508	0.25
chr1_17528561_17528716	0.21	PADI1	peptidyl arginine deiminase, type I	2983	0.24
chr4_11485827_11485978	0.20	HS3ST1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	54513	0.15
chr17_75852916_75853128	0.20	FLJ45079		25637	0.21
chr3_71478840_71479018	0.20	ENSG00000221264	.	112311	0.06
chr1_149671876_149672028	0.20	ENSG00000252925	.	84	0.95
chr5_172276989_172277188	0.20	ERGIC1	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1	15674	0.18
chr5_79514604_79514773	0.20	ENSG00000239159	.	20720	0.18
chr1_155164076_155164322	0.20	ENSG00000271748	.	769	0.29
chr1_113218156_113218412	0.20	MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	917	0.41
chr10_102883372_102883523	0.20	HUG1		911	0.45
chr18_74818276_74818427	0.20	MBP	myelin basic protein	1134	0.65
chr11_63320557_63320842	0.20	HRASLS2	HRAS-like suppressor 2	10156	0.14
chr7_36903489_36903640	0.20	AC007349.7		24987	0.21
chr3_183852789_183852940	0.20	RP11-778D9.12		105	0.61
chr16_57571934_57572100	0.20	CCDC102A	coiled-coil domain containing 102A	1506	0.32
chr19_5131766_5131917	0.20	CTC-482H14.5		46289	0.14
chr12_110152820_110153060	0.20	FAM222A	family with sequence similarity 222, member A	907	0.57
chr22_40351436_40351587	0.19	RP3-370M22.8		4890	0.19
chr1_50798531_50798682	0.19	DMRTA2	DMRT-like family A2	88698	0.08
chr22_24114548_24114738	0.19	MMP11	matrix metallopeptidase 11 (stromelysin 3)	363	0.73
chr9_139638980_139639131	0.19	LCN6	lipocalin 6	1419	0.17
chr19_41283121_41283278	0.19	RAB4B	RAB4B, member RAS oncogene family	922	0.38
chr15_100879150_100879301	0.19	ADAMTS17	ADAM metallopeptidase with thrombospondin type 1 motif, 17	2116	0.38
chr12_95948421_95948708	0.19	USP44	ubiquitin specific peptidase 44	3298	0.29
chr11_61658047_61658230	0.19	FADS3	fatty acid desaturase 3	715	0.56
chr10_122838831_122838982	0.19	RP11-95I16.4		198727	0.03
chr9_33598113_33598264	0.19	ANKRD18B	ankyrin repeat domain 18B	31087	0.16
chr1_22431845_22432053	0.19	WNT4	wingless-type MMTV integration site family, member 4	24395	0.14
chr1_164681139_164681290	0.19	RP11-477H21.2		31892	0.17
chr8_94939759_94939910	0.19	PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1	7727	0.2
chr5_164656573_164656724	0.19	CTC-340A15.2		256154	0.02
chr9_100931880_100932361	0.19	CORO2A	coronin, actin binding protein, 2A	3046	0.28
chr12_22094764_22094915	0.19	ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	503	0.86
chr20_61336843_61336994	0.19	NTSR1	neurotensin receptor 1 (high affinity)	3271	0.17
chr11_44602575_44602781	0.19	CD82	CD82 molecule	8050	0.21
chr1_16397449_16397600	0.19	FAM131C	family with sequence similarity 131, member C	2597	0.19
chr15_75085244_75085458	0.18	CSK	c-src tyrosine kinase	34	0.96
chr9_130860850_130861229	0.18	SLC25A25	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	203	0.86
chr14_99658154_99658305	0.18	AL162151.4		33476	0.19
chr22_45575232_45575448	0.18	CTA-268H5.12		469	0.78
chr16_68389761_68390217	0.18	SMPD3	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	14919	0.11
chr1_22431010_22431376	0.18	WNT4	wingless-type MMTV integration site family, member 4	25151	0.14
chr20_1645928_1646301	0.18	ENSG00000242348	.	892	0.53
chr16_3041774_3041925	0.18	PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	11309	0.06
chr22_38239565_38239763	0.18	ANKRD54	ankyrin repeat domain 54	225	0.76
chr13_111827848_111827999	0.18	ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	9362	0.21
chr16_66981924_66982095	0.18	CES2	carboxylesterase 2	6954	0.1
chr3_47822493_47822880	0.18	SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	721	0.64
chr22_19941094_19941245	0.18	COMT	catechol-O-methyltransferase	2143	0.21
chr19_7879999_7880360	0.18	EVI5L	ecotropic viral integration site 5-like	14940	0.11
chr1_241715300_241715453	0.18	KMO	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	16559	0.2
chr1_23782598_23782924	0.18	ASAP3	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	19591	0.15
chr14_100770690_100770841	0.18	SLC25A29	solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29	2013	0.15
chr15_82815495_82815646	0.17	RPS17	ribosomal protein S17	9273	0.13
chr19_14360660_14360876	0.17	ENSG00000240803	.	36904	0.12
chr9_139693729_139693891	0.17	CCDC183	coiled-coil domain containing 183	2995	0.09
chr14_96672312_96672463	0.17	RP11-404P21.8	Uncharacterized protein	1206	0.28
chr10_73868827_73869016	0.17	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	20131	0.19
chr11_107462742_107462904	0.17	AP000889.3	HCG2032453; Uncharacterized protein; cDNA FLJ25337 fis, clone TST00714	352	0.75
chr16_89381961_89382285	0.17	AC137932.6		5418	0.14
chr2_95739738_95739985	0.17	AC103563.9		20940	0.15
chr12_10096318_10096469	0.17	CLEC12A	C-type lectin domain family 12, member A	7522	0.14
chr14_72944519_72944815	0.17	RGS6	regulator of G-protein signaling 6	18290	0.3
chr17_66457525_66457769	0.17	WIPI1	WD repeat domain, phosphoinositide interacting 1	4027	0.24
chr7_1979297_1979561	0.17	MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	756	0.75
chr1_23467281_23467432	0.17	LUZP1	leucine zipper protein 1	7184	0.15
chr15_40744962_40745272	0.17	RP11-64K12.9		1721	0.2
chr2_234328201_234328490	0.17	DGKD	diacylglycerol kinase, delta 130kDa	31545	0.14
chr3_195510901_195511052	0.17	MUC4	mucin 4, cell surface associated	27752	0.16
chr10_115718028_115718215	0.17	AL162407.1	CDNA FLJ20147 fis, clone COL07954; HCG1781466; Uncharacterized protein	43591	0.15
chr5_131336683_131336834	0.16	ACSL6	acyl-CoA synthetase long-chain family member 6	816	0.51
chr2_238612428_238612611	0.16	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1	11537	0.23
chr2_69135046_69135527	0.16	BMP10	bone morphogenetic protein 10	36637	0.14
chr12_131589732_131589883	0.16	GPR133	G protein-coupled receptor 133	28491	0.22
chr17_28058860_28059011	0.16	RP11-82O19.1		29186	0.12
chr11_71790575_71790772	0.16	LRTOMT	leucine rich transmembrane and O-methyltransferase domain containing	709	0.3
chr16_58028000_58028151	0.16	USB1	U6 snRNA biogenesis 1	5375	0.14
chr16_2016679_2016830	0.16	RNF151	ring finger protein 151	70	0.87
chr16_30126670_30126821	0.16	GDPD3	glycerophosphodiester phosphodiesterase domain containing 3	1568	0.18
chr18_21545810_21546103	0.16	LAMA3	laminin, alpha 3	16099	0.17
chr16_89683361_89683581	0.16	DPEP1	dipeptidase 1 (renal)	190	0.9
chr5_39424663_39424814	0.16	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	232	0.96
chr8_20123247_20123547	0.16	LZTS1	leucine zipper, putative tumor suppressor 1	10594	0.19
chr2_20416614_20416765	0.16	SDC1	syndecan 1	7352	0.18
chr11_779046_779197	0.16	AP006621.5	Protein LOC100506518	1539	0.14
chr4_57519568_57519739	0.16	HOPX	HOP homeobox	2817	0.33
chr20_58631320_58631688	0.16	C20orf197	chromosome 20 open reading frame 197	524	0.84
chr14_77234089_77234240	0.16	VASH1	vasohibin 1	5492	0.2
chr3_195511254_195511405	0.16	MUC4	mucin 4, cell surface associated	27399	0.16
chr3_195869426_195869577	0.16	ENSG00000222335	.	59719	0.08
chr6_45344988_45345167	0.16	SUPT3H	suppressor of Ty 3 homolog (S. cerevisiae)	593	0.8
chr12_89637392_89637703	0.16	ENSG00000238302	.	38515	0.21
chr7_1550873_1551095	0.16	AC102953.6		1921	0.25
chr17_47950561_47950712	0.16	TAC4	tachykinin 4 (hemokinin)	25257	0.14
chr3_49943488_49944003	0.16	CTD-2330K9.3	Uncharacterized protein	2325	0.15
chr12_50923067_50923325	0.16	DIP2B	DIP2 disco-interacting protein 2 homolog B (Drosophila)	24306	0.2
chr15_99193531_99193682	0.16	IGF1R	insulin-like growth factor 1 receptor	1333	0.47
chr5_78536418_78536569	0.16	JMY	junction mediating and regulatory protein, p53 cofactor	4481	0.21
chr17_1551569_1551807	0.16	RILP	Rab interacting lysosomal protein	638	0.52
chr11_67172390_67172692	0.16	TBC1D10C	TBC1 domain family, member 10C	881	0.31
chr19_8274918_8275235	0.15	CERS4	ceramide synthase 4	558	0.73
chr1_154411097_154411248	0.15	IL6R	interleukin 6 receptor	4043	0.16
chr19_47470311_47470585	0.15	ENSG00000252071	.	18902	0.16
chr14_75373804_75373955	0.15	RPS6KL1	ribosomal protein S6 kinase-like 1	281	0.88
chr8_61842061_61842681	0.15	RP11-33I11.2		120206	0.06
chr2_99097622_99097974	0.15	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	36385	0.18
chr1_25343231_25343513	0.15	ENSG00000264371	.	6622	0.23
chr17_48241684_48241835	0.15	RP11-893F2.14		918	0.34
chr7_1977641_1977792	0.15	MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	2469	0.37
chr10_17465687_17466122	0.15	ST8SIA6-AS1	ST8SIA6 antisense RNA 1	15878	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0000089	mitotic metaphase(GO:0000089)
0.1	0.3	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.2	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.1	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.2	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.2	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.4	GO:0006085	acetyl-CoA biosynthetic process(GO:0006085)
0.0	0.3	GO:0021527	spinal cord association neuron differentiation(GO:0021527)
0.0	0.1	GO:0019049	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0014889	muscle atrophy(GO:0014889)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0034088	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.1	GO:0019614	phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.1	GO:0032057	negative regulation of translational initiation in response to stress(GO:0032057)
0.0	0.2	GO:1904031	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:0022417	protein maturation by protein folding(GO:0022417)
0.0	0.0	GO:0052251	induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0	0.1	GO:0019720	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.2	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.1	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.0	GO:0002885	positive regulation of hypersensitivity(GO:0002885)
0.0	0.0	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.3	GO:0045103	intermediate filament-based process(GO:0045103)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.1	GO:0051322	anaphase(GO:0051322)
0.0	0.0	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.0	GO:0031167	rRNA methylation(GO:0031167)
0.0	0.0	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.1	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0	0.1	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0060017	parathyroid gland development(GO:0060017)
0.0	0.0	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.0	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.0	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.0	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.0	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.0	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.1	GO:0003407	neural retina development(GO:0003407)
0.0	0.0	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.1	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0	0.1	GO:0010759	positive regulation of macrophage chemotaxis(GO:0010759)
0.0	0.0	GO:0050685	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.1	GO:0007096	regulation of exit from mitosis(GO:0007096)
0.0	0.0	GO:0032966	negative regulation of collagen biosynthetic process(GO:0032966)
0.0	0.1	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.0	GO:0001821	histamine secretion(GO:0001821)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.1	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.4	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.1	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.1	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0030681	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.2	GO:0045495	P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0	0.1	GO:0002102	podosome(GO:0002102)
0.0	0.0	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.0	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.3	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.5	GO:1903293	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0	0.2	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0005851	eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0	0.0	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.1	0.2	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.2	GO:0046870	cadmium ion binding(GO:0046870)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.3	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.1	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.0	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	0.8	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.2	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.1	GO:0034594	phosphatidylinositol trisphosphate phosphatase activity(GO:0034594)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.2	GO:0015278	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.0	GO:0035241	protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0	0.0	GO:0001601	peptide YY receptor activity(GO:0001601)
0.0	0.0	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.1	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.0	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.0	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.0	GO:0019863	IgE binding(GO:0019863)
0.0	0.2	GO:0016986	obsolete transcription initiation factor activity(GO:0016986)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.0	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0080032	methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.2	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.5	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.0	0.1	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.0	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.0	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.1	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.2	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	0.1	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.0	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.2	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	0.0	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.0	0.0	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.6	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.3	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.4	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.2	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC