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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for SREBF2

Z-value: 1.07

Motif logo

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Transcription factors associated with SREBF2

Gene Symbol Gene ID Gene Info
SREBF2
ENSG00000198911.7 sterol regulatory element binding transcription factor 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr22_42229661_42229812SREBF26270.4845460.674.9e-02Click!
chr22_42228218_42228405SREBF27980.4834100.637.0e-02Click!
chr22_42269933_42270084SREBF2246720.0941670.541.3e-01Click!
chr22_42226223_42226448SREBF227740.1685470.472.0e-01Click!
chr22_42222831_42222982SREBF262030.125767-0.353.5e-01Click!

Activity of the SREBF2 motif across conditions

Conditions sorted by the z-value of the SREBF2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr9_92445809_92446274 0.62 GADD45G
 growth arrest and DNA-damage-inducible, gamma
 226088
 0.02
chr3_111851090_111851324 0.56 GCSAM
 germinal center-associated, signaling and motility
 865
 0.43
chr3_195508119_195508270 0.50 MUC4
 mucin 4, cell surface associated
 30534
 0.15
chr21_47036065_47036221 0.50 PCBP3
 poly(rC) binding protein 3
 27465
 0.2
chr3_195506341_195506492 0.48 MUC4
 mucin 4, cell surface associated
 32312
 0.15
chr3_195511774_195511925 0.47 MUC4
 mucin 4, cell surface associated
 26879
 0.16
chr7_1957992_1958143 0.46 MAD1L1
 MAD1 mitotic arrest deficient-like 1 (yeast)
 22118
 0.21
chr13_114909698_114910252 0.46 RASA3
 RAS p21 protein activator 3
 11889
 0.21
chr17_2680360_2680552 0.41 RAP1GAP2
 RAP1 GTPase activating protein 2
 106
 0.96
chr17_65420745_65420896 0.41 ENSG00000201547
 .
 15823
 0.13
chr1_22463906_22464057 0.41 WNT4
 wingless-type MMTV integration site family, member 4
 5478
 0.23
chr13_114873706_114873857 0.40 RASA3-IT1
 RASA3 intronic transcript 1 (non-protein coding)
 514
 0.83
chr22_24037895_24038125 0.39 RGL4
 ral guanine nucleotide dissociation stimulator-like 4
 661
 0.59
chr20_25071203_25071354 0.38 VSX1
 visual system homeobox 1
 8282
 0.21
chr13_114873900_114874051 0.37 RASA3-IT1
 RASA3 intronic transcript 1 (non-protein coding)
 320
 0.91
chr2_95722386_95722537 0.37 AC103563.9
3540
 0.21
chr16_66914734_66914885 0.36 PDP2
 pyruvate dehyrogenase phosphatase catalytic subunit 2
 299
 0.82
chr22_21195460_21195707 0.36 PI4KA
 phosphatidylinositol 4-kinase, catalytic, alpha
 17487
 0.13
chr1_118198517_118198668 0.34 ENSG00000212266
 .
 32772
 0.18
chr10_22540636_22540794 0.34 EBLN1
 endogenous Bornavirus-like nucleoprotein 1
 41765
 0.14
chr9_95895847_95895998 0.33 NINJ1
 ninjurin 1
 648
 0.7
chr19_3668661_3668812 0.33 AC004637.1
3844
 0.14
chr1_33168985_33169202 0.33 SYNC
 syncoilin, intermediate filament protein
 104
 0.96
chr9_126168451_126168602 0.32 ENSG00000207991
 .
 3644
 0.28
chr20_62178843_62178994 0.32 SRMS
 src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
 61
 0.95
chr2_109761328_109761479 0.32 ENSG00000264934
 .
 3359
 0.3
chr20_20350513_20350736 0.32 INSM1
 insulinoma-associated 1
 1859
 0.42
chr3_195507832_195507983 0.31 MUC4
 mucin 4, cell surface associated
 30821
 0.15
chr15_99129470_99129621 0.31 RP11-35O15.1
61055
 0.12
chr4_6280365_6280536 0.31 WFS1
 Wolfram syndrome 1 (wolframin)
 8873
 0.27
chr9_95834831_95835050 0.30 SUSD3
 sushi domain containing 3
 3558
 0.21
chr3_195507349_195507500 0.30 MUC4
 mucin 4, cell surface associated
 31304
 0.15
chr13_100034854_100035070 0.30 ENSG00000207719
 .
 26577
 0.18
chr11_112096736_112096896 0.30 PTS
 6-pyruvoyltetrahydropterin synthase
 272
 0.85
chr6_37666582_37666733 0.29 MDGA1
 MAM domain containing glycosylphosphatidylinositol anchor 1
 425
 0.89
chr11_65556019_65556254 0.29 OVOL1-AS1
 OVOL1 antisense RNA 1
 1210
 0.25
chr14_61905397_61905581 0.28 PRKCH
 protein kinase C, eta
 3787
 0.3
chr8_66702583_66702734 0.28 PDE7A
 phosphodiesterase 7A
 1339
 0.55
chr1_91565606_91565979 0.27 ZNF644
 zinc finger protein 644
 77963
 0.12
chr10_11287242_11287547 0.27 RP3-323N1.2
74055
 0.1
chr2_9897660_9897811 0.27 ENSG00000200034
 .
 16823
 0.23
chr20_62683213_62683364 0.26 SOX18
 SRY (sex determining region Y)-box 18
 2294
 0.14
chr2_197047764_197047992 0.26 STK17B
 serine/threonine kinase 17b
 6651
 0.2
chr14_99699047_99699313 0.26 AL109767.1
30105
 0.18
chr4_6918352_6918503 0.26 TBC1D14
 TBC1 domain family, member 14
 6452
 0.19
chr18_46370124_46370275 0.26 RP11-484L8.1
9058
 0.27
chr10_105506823_105507043 0.26 SH3PXD2A
 SH3 and PX domains 2A
 54003
 0.12
chr10_130075967_130076118 0.26 MKI67
 marker of proliferation Ki-67
 151393
 0.04
chr11_66060029_66060180 0.26 TMEM151A
 transmembrane protein 151A
 763
 0.33
chr21_45583294_45583445 0.25 AP001055.1
10211
 0.14
chr16_85599289_85599463 0.25 GSE1
 Gse1 coiled-coil protein
 45639
 0.15
chr3_31329622_31329773 0.25 ENSG00000222983
 .
 59490
 0.15
chr9_129481687_129481848 0.25 ENSG00000266403
 .
 1155
 0.56
chr3_5019096_5019422 0.25 BHLHE40
 basic helix-loop-helix family, member e40
 1542
 0.37
chrX_7000781_7000932 0.25 ENSG00000264268
 .
 65045
 0.13
chr4_154573712_154573880 0.25 RP11-153M7.3
25615
 0.18
chr15_63895899_63896141 0.24 USP3-AS1
 USP3 antisense RNA 1
 2232
 0.3
chr7_79081789_79081970 0.24 ENSG00000234456
 .
 319
 0.81
chr16_8960877_8961130 0.24 CARHSP1
 calcium regulated heat stable protein 1, 24kDa
 282
 0.84
chr7_76073300_76073451 0.24 ZP3
 zona pellucida glycoprotein 3 (sperm receptor)
 10588
 0.14
chr11_2912733_2913001 0.24 SLC22A18AS
 solute carrier family 22 (organic cation transporter), member 18 antisense
 2207
 0.19
chr1_161039848_161040008 0.24 ARHGAP30
 Rho GTPase activating protein 30
 168
 0.87
chr1_76081137_76081358 0.23 SLC44A5
 solute carrier family 44, member 5
 4446
 0.28
chr9_119465090_119465241 0.23 TRIM32
 tripartite motif containing 32
 15543
 0.22
chr14_68843315_68843480 0.23 RAD51B
 RAD51 paralog B
 34830
 0.22
chr20_31109331_31109482 0.23 C20orf112
 chromosome 20 open reading frame 112
 749
 0.66
chr1_32682080_32682262 0.23 EIF3I
 eukaryotic translation initiation factor 3, subunit I
 5358
 0.08
chr20_36432319_36432470 0.23 CTNNBL1
 catenin, beta like 1
 26719
 0.22
chr16_78782975_78783145 0.23 RP11-319G9.3
148002
 0.04
chr4_99919820_99919971 0.23 ENSG00000265213
 .
 1357
 0.36
chr1_43398814_43399160 0.23 SLC2A1
 solute carrier family 2 (facilitated glucose transporter), member 1
 2191
 0.3
chr12_6570561_6570923 0.23 VAMP1
 vesicle-associated membrane protein 1 (synaptobrevin 1)
 9069
 0.09
chr11_44326954_44327198 0.22 ALX4
 ALX homeobox 4
 4640
 0.33
chr16_56691235_56691435 0.22 MT1F
 metallothionein 1F
 271
 0.77
chr14_77334150_77334556 0.22 ENSG00000223174
 .
 22253
 0.17
chr18_53254709_53254980 0.22 TCF4
 transcription factor 4
 497
 0.87
chrX_119592645_119592909 0.22 LAMP2
 lysosomal-associated membrane protein 2
 10070
 0.23
chr7_2750332_2750483 0.22 AMZ1
 archaelysin family metallopeptidase 1
 22571
 0.19
chr13_40779803_40779954 0.22 ENSG00000207458
 .
 21086
 0.28
chr1_200515720_200515871 0.22 KIF14
 kinesin family member 14
 74067
 0.11
chr1_203596210_203596415 0.22 ATP2B4
 ATPase, Ca++ transporting, plasma membrane 4
 384
 0.9
chr4_3303410_3303667 0.21 RGS12
 regulator of G-protein signaling 12
 7224
 0.25
chr18_5417488_5417739 0.21 EPB41L3
 erythrocyte membrane protein band 4.1-like 3
 2187
 0.38
chr15_42124634_42124785 0.21 JMJD7-PLA2G4B
 JMJD7-PLA2G4B readthrough
 4394
 0.11
chr11_1800747_1800898 0.21 CTSD
 cathepsin D
 15600
 0.08
chr16_2198362_2198540 0.21 RAB26
 RAB26, member RAS oncogene family
 174
 0.83
chr21_45341659_45341920 0.21 ENSG00000199598
 .
 2007
 0.29
chr4_146100468_146100690 0.21 OTUD4
 OTU domain containing 4
 184
 0.96
chr3_4864499_4864721 0.21 ENSG00000239126
 .
 55776
 0.13
chr17_80188379_80188575 0.21 SLC16A3
 solute carrier family 16 (monocarboxylate transporter), member 3
 1508
 0.25
chr1_17528561_17528716 0.21 PADI1
 peptidyl arginine deiminase, type I
 2983
 0.24
chr4_11485827_11485978 0.20 HS3ST1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
 54513
 0.15
chr17_75852916_75853128 0.20 FLJ45079
25637
 0.21
chr3_71478840_71479018 0.20 ENSG00000221264
 .
 112311
 0.06
chr1_149671876_149672028 0.20 ENSG00000252925
 .
 84
 0.95
chr5_172276989_172277188 0.20 ERGIC1
 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
 15674
 0.18
chr5_79514604_79514773 0.20 ENSG00000239159
 .
 20720
 0.18
chr1_155164076_155164322 0.20 ENSG00000271748
 .
 769
 0.29
chr1_113218156_113218412 0.20 MOV10
 Mov10, Moloney leukemia virus 10, homolog (mouse)
 917
 0.41
chr10_102883372_102883523 0.20 HUG1
911
 0.45
chr18_74818276_74818427 0.20 MBP
 myelin basic protein
 1134
 0.65
chr11_63320557_63320842 0.20 HRASLS2
 HRAS-like suppressor 2
 10156
 0.14
chr7_36903489_36903640 0.20 AC007349.7
24987
 0.21
chr3_183852789_183852940 0.20 RP11-778D9.12
105
 0.61
chr16_57571934_57572100 0.20 CCDC102A
 coiled-coil domain containing 102A
 1506
 0.32
chr19_5131766_5131917 0.20 CTC-482H14.5
46289
 0.14
chr12_110152820_110153060 0.20 FAM222A
 family with sequence similarity 222, member A
 907
 0.57
chr22_40351436_40351587 0.19 RP3-370M22.8
4890
 0.19
chr1_50798531_50798682 0.19 DMRTA2
 DMRT-like family A2
 88698
 0.08
chr22_24114548_24114738 0.19 MMP11
 matrix metallopeptidase 11 (stromelysin 3)
 363
 0.73
chr9_139638980_139639131 0.19 LCN6
 lipocalin 6
 1419
 0.17
chr19_41283121_41283278 0.19 RAB4B
 RAB4B, member RAS oncogene family
 922
 0.38
chr15_100879150_100879301 0.19 ADAMTS17
 ADAM metallopeptidase with thrombospondin type 1 motif, 17
 2116
 0.38
chr12_95948421_95948708 0.19 USP44
 ubiquitin specific peptidase 44
 3298
 0.29
chr11_61658047_61658230 0.19 FADS3
 fatty acid desaturase 3
 715
 0.56
chr10_122838831_122838982 0.19 RP11-95I16.4
198727
 0.03
chr9_33598113_33598264 0.19 ANKRD18B
 ankyrin repeat domain 18B
 31087
 0.16
chr1_22431845_22432053 0.19 WNT4
 wingless-type MMTV integration site family, member 4
 24395
 0.14
chr1_164681139_164681290 0.19 RP11-477H21.2
31892
 0.17
chr8_94939759_94939910 0.19 PDP1
 pyruvate dehyrogenase phosphatase catalytic subunit 1
 7727
 0.2
chr5_164656573_164656724 0.19 CTC-340A15.2
256154
 0.02
chr9_100931880_100932361 0.19 CORO2A
 coronin, actin binding protein, 2A
 3046
 0.28
chr12_22094764_22094915 0.19 ABCC9
 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
 503
 0.86
chr20_61336843_61336994 0.19 NTSR1
 neurotensin receptor 1 (high affinity)
 3271
 0.17
chr11_44602575_44602781 0.19 CD82
 CD82 molecule
 8050
 0.21
chr1_16397449_16397600 0.19 FAM131C
 family with sequence similarity 131, member C
 2597
 0.19
chr15_75085244_75085458 0.18 CSK
 c-src tyrosine kinase
 34
 0.96
chr9_130860850_130861229 0.18 SLC25A25
 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
 203
 0.86
chr14_99658154_99658305 0.18 AL162151.4
33476
 0.19
chr22_45575232_45575448 0.18 CTA-268H5.12
469
 0.78
chr16_68389761_68390217 0.18 SMPD3
 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
 14919
 0.11
chr1_22431010_22431376 0.18 WNT4
 wingless-type MMTV integration site family, member 4
 25151
 0.14
chr20_1645928_1646301 0.18 ENSG00000242348
 .
 892
 0.53
chr16_3041774_3041925 0.18 PKMYT1
 protein kinase, membrane associated tyrosine/threonine 1
 11309
 0.06
chr22_38239565_38239763 0.18 ANKRD54
 ankyrin repeat domain 54
 225
 0.76
chr13_111827848_111827999 0.18 ARHGEF7
 Rho guanine nucleotide exchange factor (GEF) 7
 9362
 0.21
chr16_66981924_66982095 0.18 CES2
 carboxylesterase 2
 6954
 0.1
chr3_47822493_47822880 0.18 SMARCC1
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
 721
 0.64
chr22_19941094_19941245 0.18 COMT
 catechol-O-methyltransferase
 2143
 0.21
chr19_7879999_7880360 0.18 EVI5L
 ecotropic viral integration site 5-like
 14940
 0.11
chr1_241715300_241715453 0.18 KMO
 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
 16559
 0.2
chr1_23782598_23782924 0.18 ASAP3
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
 19591
 0.15
chr14_100770690_100770841 0.18 SLC25A29
 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
 2013
 0.15
chr15_82815495_82815646 0.17 RPS17
 ribosomal protein S17
 9273
 0.13
chr19_14360660_14360876 0.17 ENSG00000240803
 .
 36904
 0.12
chr9_139693729_139693891 0.17 CCDC183
 coiled-coil domain containing 183
 2995
 0.09
chr14_96672312_96672463 0.17 RP11-404P21.8
 Uncharacterized protein
 1206
 0.28
chr10_73868827_73869016 0.17 SPOCK2
 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
 20131
 0.19
chr11_107462742_107462904 0.17 AP000889.3
 HCG2032453; Uncharacterized protein; cDNA FLJ25337 fis, clone TST00714
 352
 0.75
chr16_89381961_89382285 0.17 AC137932.6
5418
 0.14
chr2_95739738_95739985 0.17 AC103563.9
20940
 0.15
chr12_10096318_10096469 0.17 CLEC12A
 C-type lectin domain family 12, member A
 7522
 0.14
chr14_72944519_72944815 0.17 RGS6
 regulator of G-protein signaling 6
 18290
 0.3
chr17_66457525_66457769 0.17 WIPI1
 WD repeat domain, phosphoinositide interacting 1
 4027
 0.24
chr7_1979297_1979561 0.17 MAD1L1
 MAD1 mitotic arrest deficient-like 1 (yeast)
 756
 0.75
chr1_23467281_23467432 0.17 LUZP1
 leucine zipper protein 1
 7184
 0.15
chr15_40744962_40745272 0.17 RP11-64K12.9
1721
 0.2
chr2_234328201_234328490 0.17 DGKD
 diacylglycerol kinase, delta 130kDa
 31545
 0.14
chr3_195510901_195511052 0.17 MUC4
 mucin 4, cell surface associated
 27752
 0.16
chr10_115718028_115718215 0.17 AL162407.1
 CDNA FLJ20147 fis, clone COL07954; HCG1781466; Uncharacterized protein
 43591
 0.15
chr5_131336683_131336834 0.16 ACSL6
 acyl-CoA synthetase long-chain family member 6
 816
 0.51
chr2_238612428_238612611 0.16 LRRFIP1
 leucine rich repeat (in FLII) interacting protein 1
 11537
 0.23
chr2_69135046_69135527 0.16 BMP10
 bone morphogenetic protein 10
 36637
 0.14
chr12_131589732_131589883 0.16 GPR133
 G protein-coupled receptor 133
 28491
 0.22
chr17_28058860_28059011 0.16 RP11-82O19.1
29186
 0.12
chr11_71790575_71790772 0.16 LRTOMT
 leucine rich transmembrane and O-methyltransferase domain containing
 709
 0.3
chr16_58028000_58028151 0.16 USB1
 U6 snRNA biogenesis 1
 5375
 0.14
chr16_2016679_2016830 0.16 RNF151
 ring finger protein 151
 70
 0.87
chr16_30126670_30126821 0.16 GDPD3
 glycerophosphodiester phosphodiesterase domain containing 3
 1568
 0.18
chr18_21545810_21546103 0.16 LAMA3
 laminin, alpha 3
 16099
 0.17
chr16_89683361_89683581 0.16 DPEP1
 dipeptidase 1 (renal)
 190
 0.9
chr5_39424663_39424814 0.16 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
 232
 0.96
chr8_20123247_20123547 0.16 LZTS1
 leucine zipper, putative tumor suppressor 1
 10594
 0.19
chr2_20416614_20416765 0.16 SDC1
 syndecan 1
 7352
 0.18
chr11_779046_779197 0.16 AP006621.5
 Protein LOC100506518
 1539
 0.14
chr4_57519568_57519739 0.16 HOPX
 HOP homeobox
 2817
 0.33
chr20_58631320_58631688 0.16 C20orf197
 chromosome 20 open reading frame 197
 524
 0.84
chr14_77234089_77234240 0.16 VASH1
 vasohibin 1
 5492
 0.2
chr3_195511254_195511405 0.16 MUC4
 mucin 4, cell surface associated
 27399
 0.16
chr3_195869426_195869577 0.16 ENSG00000222335
 .
 59719
 0.08
chr6_45344988_45345167 0.16 SUPT3H
 suppressor of Ty 3 homolog (S. cerevisiae)
 593
 0.8
chr12_89637392_89637703 0.16 ENSG00000238302
 .
 38515
 0.21
chr7_1550873_1551095 0.16 AC102953.6
1921
 0.25
chr17_47950561_47950712 0.16 TAC4
 tachykinin 4 (hemokinin)
 25257
 0.14
chr3_49943488_49944003 0.16 CTD-2330K9.3
 Uncharacterized protein
 2325
 0.15
chr12_50923067_50923325 0.16 DIP2B
 DIP2 disco-interacting protein 2 homolog B (Drosophila)
 24306
 0.2
chr15_99193531_99193682 0.16 IGF1R
 insulin-like growth factor 1 receptor
 1333
 0.47
chr5_78536418_78536569 0.16 JMY
 junction mediating and regulatory protein, p53 cofactor
 4481
 0.21
chr17_1551569_1551807 0.16 RILP
 Rab interacting lysosomal protein
 638
 0.52
chr11_67172390_67172692 0.16 TBC1D10C
 TBC1 domain family, member 10C
 881
 0.31
chr19_8274918_8275235 0.15 CERS4
 ceramide synthase 4
 558
 0.73
chr1_154411097_154411248 0.15 IL6R
 interleukin 6 receptor
 4043
 0.16
chr19_47470311_47470585 0.15 ENSG00000252071
 .
 18902
 0.16
chr14_75373804_75373955 0.15 RPS6KL1
 ribosomal protein S6 kinase-like 1
 281
 0.88
chr8_61842061_61842681 0.15 RP11-33I11.2
120206
 0.06
chr2_99097622_99097974 0.15 INPP4A
 inositol polyphosphate-4-phosphatase, type I, 107kDa
 36385
 0.18
chr1_25343231_25343513 0.15 ENSG00000264371
 .
 6622
 0.23
chr17_48241684_48241835 0.15 RP11-893F2.14
918
 0.34
chr7_1977641_1977792 0.15 MAD1L1
 MAD1 mitotic arrest deficient-like 1 (yeast)
 2469
 0.37
chr10_17465687_17466122 0.15 ST8SIA6-AS1
 ST8SIA6 antisense RNA 1
 15878
 0.18

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0000089 mitotic metaphase(GO:0000089)
0.1 0.3 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0 0.1 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.1 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.0 0.2 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0070295 renal water absorption(GO:0070295)
0.0 0.2 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.2 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.4 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.0 0.3 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.1 GO:0019049 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0014889 muscle atrophy(GO:0014889)
0.0 0.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0045341 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.0 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.1 GO:0034088 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0 0.1 GO:0019614 phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.1 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.0 0.2 GO:1904031 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 0.1 GO:0022417 protein maturation by protein folding(GO:0022417)
0.0 0.0 GO:0052251 induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0 0.1 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.2 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0050687 negative regulation of defense response to virus(GO:0050687)
0.0 0.0 GO:0002885 positive regulation of hypersensitivity(GO:0002885)
0.0 0.0 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.1 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.3 GO:0045103 intermediate filament-based process(GO:0045103)
0.0 0.1 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.1 GO:0051322 anaphase(GO:0051322)
0.0 0.0 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.0 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.0 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.0 0.1 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.1 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.1 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.0 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.0 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.0 0.0 GO:0051573 negative regulation of histone H3-K9 methylation(GO:0051573)
0.0 0.0 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.0 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.0 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:0003407 neural retina development(GO:0003407)
0.0 0.0 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.1 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0 0.1 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.0 GO:0050685 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.1 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.0 GO:0032966 negative regulation of collagen biosynthetic process(GO:0032966)
0.0 0.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.0 GO:0001821 histamine secretion(GO:0001821)
0.0 0.0 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.0 0.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.1 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.1 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.1 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.2 GO:0045495 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 0.0 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.0 GO:1903561 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.1 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.0 0.5 GO:1903293 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.0 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.1 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0045179 apical cortex(GO:0045179)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.2 GO:0046870 cadmium ion binding(GO:0046870)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.1 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.3 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0 0.0 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 0.1 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity(GO:0034594)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.2 GO:0015278 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.0 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.0 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.0 GO:0001601 peptide YY receptor activity(GO:0001601)
0.0 0.0 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.1 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.0 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.1 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.0 GO:0019863 IgE binding(GO:0019863)
0.0 0.2 GO:0016986 obsolete transcription initiation factor activity(GO:0016986)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.0 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0080032 methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.0 GO:0071723 lipopeptide binding(GO:0071723)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.0 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.1 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.0 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.0 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.0 0.0 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.0 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.0 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC