Project

ENCODE: H3K4me1 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SRF

Z-value: 1.68

Motif logo

Transcription factors associated with SRF

Gene Symbol	Gene ID	Gene Info
SRF Ensembl NCBI GeneCards UniProt	ENSG00000112658.6	SRF

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SRF	chr6_43138501_43138804	385	0.786329	-0.64	6.3e-02	Click!
SRF	chr6_43140630_43141425	899	0.462382	-0.51	1.6e-01	Click!
SRF	chr6_43141521_43141708	1486	0.287844	0.51	1.6e-01	Click!
SRF	chr6_43142607_43142932	2641	0.179829	-0.50	1.7e-01	Click!
SRF	chr6_43138020_43138466	794	0.515173	-0.46	2.1e-01	Click!

Activity of the SRF motif across conditions

Conditions sorted by the z-value of the SRF motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_71950232_71950471	0.99	SAR1A	SAR1 homolog A (S. cerevisiae)	20072	0.17
chr11_111391090_111391372	0.99	C11orf88	chromosome 11 open reading frame 88	5721	0.11
chr7_46297529_46297680	0.93	ENSG00000239004	.	282567	0.01
chr19_13142471_13142622	0.88	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	6735	0.11
chr6_35457763_35458156	0.86	TEAD3	TEA domain family member 3	6768	0.17
chr10_112170567_112171063	0.86	ENSG00000221359	.	23184	0.2
chr15_51602118_51602364	0.84	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	8448	0.17
chr1_202003645_202003796	0.84	RP11-510N19.5		23222	0.1
chr4_47527226_47527524	0.83	AC092597.3		34901	0.16
chr10_95195819_95196061	0.82	MYOF	myoferlin	46011	0.14
chr6_136399735_136399886	0.79	RP13-143G15.3		5845	0.27
chr2_122121802_122122094	0.77	CLASP1	cytoplasmic linker associated protein 1	63098	0.13
chr9_138952025_138952443	0.74	NACC2	NACC family member 2, BEN and BTB (POZ) domain containing	9808	0.22
chr12_111873433_111874308	0.74	SH2B3	SH2B adaptor protein 3	1204	0.47
chr3_112323833_112324096	0.74	CCDC80	coiled-coil domain containing 80	5163	0.24
chrY_2545355_2545506	0.74	ENSG00000251841	.	107360	0.07
chrX_2595353_2595504	0.73	CD99	CD99 molecule	13792	0.22
chr11_130767618_130767831	0.73	SNX19	sorting nexin 19	3955	0.35
chr2_173860682_173860978	0.73	RAPGEF4	Rap guanine nucleotide exchange factor (GEF) 4	30524	0.2
chr5_43294641_43294792	0.71	CTD-2636A23.2		5219	0.23
chr5_141998017_141998291	0.71	FGF1	fibroblast growth factor 1 (acidic)	2753	0.29
chr2_85504705_85504985	0.71	ENSG00000221579	.	21312	0.12
chr14_53330178_53330329	0.70	FERMT2	fermitin family member 2	986	0.61
chr4_26050932_26051083	0.70	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	114070	0.07
chr8_96814534_96814685	0.70	ENSG00000223297	.	123466	0.06
chr4_141860055_141860206	0.69	RNF150	ring finger protein 150	58060	0.15
chr2_33382763_33382914	0.68	LTBP1	latent transforming growth factor beta binding protein 1	23114	0.25
chr5_119876090_119876241	0.68	PRR16	proline rich 16	9006	0.32
chr2_23634355_23634506	0.67	KLHL29	kelch-like family member 29	26342	0.26
chr15_51401320_51401471	0.67	TNFAIP8L3	tumor necrosis factor, alpha-induced protein 8-like 3	3922	0.27
chr9_74599531_74599682	0.67	C9orf85	chromosome 9 open reading frame 85	73029	0.09
chr7_2802071_2802373	0.67	GNA12	guanine nucleotide binding protein (G protein) alpha 12	552	0.83
chr17_73075198_73075684	0.67	SLC16A5	solute carrier family 16 (monocarboxylate transporter), member 5	8381	0.09
chr14_59800029_59800257	0.67	ENSG00000252869	.	66598	0.11
chr18_20872031_20872182	0.67	RP11-17J14.2		31788	0.2
chr8_26123678_26123924	0.66	PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	25206	0.23
chr1_219259694_219259888	0.66	LYPLAL1	lysophospholipase-like 1	87395	0.1
chr2_202999119_202999270	0.66	AC079354.3		17413	0.15
chr4_95470032_95470452	0.66	PDLIM5	PDZ and LIM domain 5	25366	0.27
chr6_132452737_132452888	0.66	ENSG00000265669	.	16409	0.27
chr11_76327363_76327514	0.66	AP001189.4		40662	0.14
chr1_68306464_68306615	0.65	GNG12	guanine nucleotide binding protein (G protein), gamma 12	7389	0.22
chr2_36659694_36659845	0.65	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	76155	0.1
chr17_64419381_64419532	0.65	RP11-4F22.2		6484	0.26
chr1_185941378_185941529	0.65	HMCN1	hemicentin 1	199066	0.03
chr2_227276660_227276915	0.65	ENSG00000263363	.	246722	0.02
chr8_41570885_41571036	0.64	ANK1	ankyrin 1, erythrocytic	7263	0.19
chr11_130273396_130273575	0.64	ADAMTS8	ADAM metallopeptidase with thrombospondin type 1 motif, 8	25403	0.2
chr16_83723296_83723447	0.64	RP11-298D21.3		28132	0.16
chr15_90121530_90121681	0.64	TICRR	TOPBP1-interacting checkpoint and replication regulator	2787	0.21
chr15_70995885_70996036	0.64	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	346	0.92
chr2_36639522_36639673	0.62	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	55983	0.15
chr2_20001512_20001663	0.61	TTC32	tetratricopeptide repeat domain 32	99815	0.08
chr3_160191590_160191741	0.61	ENSG00000238427	.	1461	0.35
chr12_6338128_6338295	0.61	ENSG00000202318	.	5410	0.19
chr18_56664990_56665141	0.61	ENSG00000251870	.	71537	0.1
chr13_32662235_32662386	0.61	FRY	furry homolog (Drosophila)	27309	0.22
chr1_95332085_95332236	0.61	SLC44A3	solute carrier family 44, member 3	727	0.68
chr1_59482045_59482243	0.60	JUN	jun proto-oncogene	232359	0.02
chr4_151201855_151202006	0.60	LRBA	LPS-responsive vesicle trafficking, beach and anchor containing	21933	0.25
chr15_83874173_83874324	0.60	HDGFRP3	Hepatoma-derived growth factor-related protein 3	2522	0.27
chr12_117302328_117302479	0.60	HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	16490	0.21
chr16_64443886_64444184	0.60	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	649546	0.0
chr1_178908514_178908665	0.60	RALGPS2	Ral GEF with PH domain and SH3 binding motif 2	53375	0.13
chr17_46559333_46559484	0.60	ENSG00000206805	.	2949	0.17
chr6_160123078_160123229	0.59	SOD2	superoxide dismutase 2, mitochondrial	8793	0.15
chr18_57488970_57489121	0.59	ENSG00000221471	.	72136	0.1
chr9_116940584_116940813	0.59	COL27A1	collagen, type XXVII, alpha 1	10703	0.21
chr1_245928780_245928931	0.59	RP11-522M21.3		89075	0.09
chr5_14193033_14193184	0.59	TRIO	trio Rho guanine nucleotide exchange factor	9201	0.32
chr7_134592506_134592657	0.58	CALD1	caldesmon 1	12656	0.27
chr11_73849202_73849353	0.58	C2CD3	C2 calcium-dependent domain containing 3	32752	0.14
chr3_58975517_58975668	0.58	C3orf67	chromosome 3 open reading frame 67	52104	0.18
chr11_102026582_102026733	0.58	YAP1	Yes-associated protein 1	30155	0.15
chr2_24051637_24051788	0.57	ATAD2B	ATPase family, AAA domain containing 2B	3769	0.31
chr5_34686863_34687019	0.57	RAI14	retinoic acid induced 14	451	0.87
chr21_46880431_46880582	0.57	COL18A1	collagen, type XVIII, alpha 1	5082	0.21
chr5_61440086_61440237	0.57	ENSG00000251983	.	2331	0.45
chr11_61656018_61656169	0.57	FADS3	fatty acid desaturase 3	2290	0.2
chr3_194296927_194297078	0.57	TMEM44-AS1	TMEM44 antisense RNA 1	7738	0.15
chr5_177975146_177975297	0.56	COL23A1	collagen, type XXIII, alpha 1	14018	0.22
chr7_41045186_41045337	0.56	AC005160.3		230104	0.02
chr16_69238182_69238401	0.56	ENSG00000200164	.	13265	0.12
chr15_35598915_35599148	0.56	ENSG00000265102	.	65534	0.14
chr11_13156552_13156703	0.56	ARNTL	aryl hydrocarbon receptor nuclear translocator-like	141572	0.04
chr6_86173167_86173318	0.56	NT5E	5'-nucleotidase, ecto (CD73)	7857	0.27
chr20_43223275_43223491	0.56	PKIG	protein kinase (cAMP-dependent, catalytic) inhibitor gamma	12193	0.15
chr1_154163009_154163193	0.56	TPM3	tropomyosin 3	1433	0.23
chr2_213708215_213708366	0.55	ENSG00000221388	.	79891	0.1
chr17_53504679_53504830	0.55	MMD	monocyte to macrophage differentiation-associated	5401	0.32
chr12_66050940_66051359	0.55	HMGA2	high mobility group AT-hook 2	166762	0.03
chr5_146910957_146911108	0.55	DPYSL3	dihydropyrimidinase-like 3	21413	0.26
chr7_127417436_127417587	0.55	SND1	staphylococcal nuclease and tudor domain containing 1	110454	0.06
chr18_33746577_33746728	0.54	RP11-49I11.1		20759	0.16
chr18_43363682_43364023	0.54	RP11-116O18.3		36672	0.14
chr3_23536791_23536942	0.54	ENSG00000265645	.	14797	0.26
chr1_17963278_17963429	0.53	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like	18504	0.26
chr13_97925911_97926062	0.53	MBNL2	muscleblind-like splicing regulator 2	2472	0.41
chr5_16913937_16914088	0.53	MYO10	myosin X	2624	0.32
chr10_101671643_101671794	0.53	DNMBP	dynamin binding protein	2121	0.33
chr11_35562990_35563282	0.53	PAMR1	peptidase domain containing associated with muscle regeneration 1	11288	0.25
chr20_8203734_8203885	0.52	PLCB1-IT1	PLCB1 intronic transcript 1 (non-protein coding)	25542	0.25
chr2_27543666_27543963	0.52	MPV17	MpV17 mitochondrial inner membrane protein	1617	0.19
chr13_110971974_110972125	0.52	COL4A2	collagen, type IV, alpha 2	12435	0.21
chr3_143774181_143774332	0.52	C3orf58	chromosome 3 open reading frame 58	81806	0.11
chr6_144570022_144570173	0.52	UTRN	utrophin	36740	0.19
chr9_21837231_21837382	0.52	MTAP	methylthioadenosine phosphorylase	17417	0.17
chr4_126309256_126309407	0.52	FAT4	FAT atypical cadherin 4	5760	0.29
chr2_214052779_214052930	0.52	IKZF2	IKAROS family zinc finger 2 (Helios)	35703	0.22
chr5_155564195_155564346	0.52	SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	189486	0.03
chr4_81228117_81228268	0.51	C4orf22	chromosome 4 open reading frame 22	28682	0.2
chr14_55768736_55768887	0.51	FBXO34	F-box protein 34	29939	0.18
chr17_56031434_56032135	0.51	CUEDC1	CUE domain containing 1	834	0.58
chr9_97758309_97758460	0.51	C9orf3	chromosome 9 open reading frame 3	8031	0.21
chr3_185531728_185531979	0.51	IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2	6996	0.24
chr1_32819059_32819503	0.51	TSSK3	testis-specific serine kinase 3	226	0.89
chr10_30151041_30151192	0.51	SVIL	supervillin	126383	0.05
chr15_33121833_33121984	0.50	FMN1	formin 1	58547	0.12
chr12_54414078_54414229	0.50	HOXC4	homeobox C4	3438	0.08
chr16_87136109_87136260	0.50	RP11-899L11.3		113337	0.06
chr1_214689137_214689772	0.50	PTPN14	protein tyrosine phosphatase, non-receptor type 14	35112	0.22
chr6_42067452_42067603	0.50	C6orf132	chromosome 6 open reading frame 132	42655	0.1
chr6_44040423_44041032	0.49	RP5-1120P11.1		1662	0.35
chr3_149180351_149180502	0.49	TM4SF4	transmembrane 4 L six family member 4	11335	0.21
chr12_43709758_43710210	0.49	ENSG00000215993	.	24601	0.27
chr5_153003397_153003548	0.49	ENSG00000242976	.	131470	0.05
chr15_33093451_33093719	0.49	GREM1	gremlin 1, DAN family BMP antagonist	70693	0.09
chr8_69837050_69837201	0.49	ENSG00000238808	.	185684	0.03
chr9_111397417_111397568	0.48	ACTL7B	actin-like 7B	221747	0.02
chr6_2468842_2468993	0.48	ENSG00000266252	.	59048	0.15
chr12_79943500_79943651	0.48	ENSG00000243714	.	24625	0.19
chr19_39150000_39150519	0.48	ACTN4	actinin, alpha 4	11881	0.12
chr12_52167059_52167210	0.48	AC068987.1	HCG1997999; cDNA FLJ33996 fis, clone DFNES2008881	36655	0.17
chr9_36332681_36332832	0.48	GNE	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	55703	0.12
chr12_16505710_16505975	0.47	MGST1	microsomal glutathione S-transferase 1	509	0.85
chr7_104607919_104608070	0.47	ENSG00000251911	.	3740	0.23
chr20_1800907_1801169	0.47	SIRPA	signal-regulatory protein alpha	74116	0.1
chr8_32962851_32963002	0.47	ENSG00000265562	.	90429	0.09
chr3_188669250_188669401	0.47	TPRG1	tumor protein p63 regulated 1	4322	0.37
chr12_91577880_91578031	0.47	DCN	decorin	1055	0.66
chr5_158477621_158478266	0.47	EBF1	early B-cell factor 1	48758	0.14
chr6_145569007_145569263	0.47	ENSG00000221796	.	100759	0.09
chr3_184918393_184918544	0.47	EHHADH-AS1	EHHADH antisense RNA 1	37779	0.14
chr18_395353_395504	0.46	RP11-720L2.2		28988	0.2
chr8_79844807_79844958	0.46	IL7	interleukin 7	127124	0.06
chr4_14112329_14112480	0.46	ENSG00000252092	.	452153	0.01
chr1_68640592_68640743	0.46	ENSG00000221203	.	8626	0.22
chr5_81561436_81561587	0.46	RPS23	ribosomal protein S23	12649	0.23
chr10_6243827_6244661	0.46	RP11-414H17.5		412	0.58
chr7_22630355_22630506	0.46	AC002480.4		1106	0.52
chr12_104253506_104253657	0.46	RP11-650K20.3	Uncharacterized protein	18352	0.14
chr22_35842229_35842380	0.46	MCM5	minichromosome maintenance complex component 5	45880	0.14
chr5_121518992_121519276	0.46	CTC-441N14.1		27424	0.17
chr4_26371195_26371346	0.46	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	7118	0.32
chr2_1576886_1577037	0.46	AC144450.1		46924	0.17
chr5_135390329_135390480	0.46	TGFBI	transforming growth factor, beta-induced, 68kDa	4134	0.24
chr6_88416816_88416967	0.46	AKIRIN2	akirin 2	4964	0.22
chr11_94809865_94810123	0.46	ENDOD1	endonuclease domain containing 1	12980	0.21
chr8_74282582_74282920	0.46	RP11-434I12.2		14055	0.25
chr14_75688690_75688954	0.45	ENSG00000252013	.	19950	0.14
chr6_113198313_113198464	0.45	ENSG00000201386	.	94307	0.09
chr8_69991685_69991836	0.45	ENSG00000238808	.	31049	0.26
chr3_27610112_27610263	0.45	ENSG00000238912	.	20838	0.22
chr9_12880763_12880914	0.45	ENSG00000222658	.	4482	0.3
chr10_30800294_30800445	0.45	ENSG00000239744	.	44464	0.15
chr20_43696508_43696659	0.45	KCNS1	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1	33167	0.12
chr3_174985020_174985171	0.44	NAALADL2-AS2	NAALADL2 antisense RNA 2	3790	0.34
chr2_36932543_36932694	0.44	VIT	vitrin	8598	0.25
chr14_65148512_65148745	0.44	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	22192	0.19
chr3_16145872_16146023	0.44	GALNT15	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15	70209	0.12
chr13_94997091_94997242	0.44	ENSG00000212057	.	120478	0.06
chr14_71709495_71709775	0.44	AC004817.1	HCG2028611; Uncharacterized protein	26173	0.21
chr14_73212557_73212708	0.44	ENSG00000206751	.	107407	0.07
chr6_86155572_86155723	0.44	NT5E	5'-nucleotidase, ecto (CD73)	4162	0.33
chr13_98508497_98508648	0.44	ENSG00000238407	.	29491	0.24
chr16_64126268_64126419	0.43	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	967238	0.0
chr13_27454838_27454989	0.43	GPR12	G protein-coupled receptor 12	119991	0.06
chr22_44707279_44707430	0.43	KIAA1644	KIAA1644	1377	0.54
chr18_66106660_66106811	0.43	TMX3	thioredoxin-related transmembrane protein 3	275559	0.02
chr8_129553232_129553525	0.43	ENSG00000221351	.	278662	0.01
chr10_100134588_100134739	0.43	ENSG00000221419	.	20401	0.18
chr2_29286777_29286928	0.43	C2orf71	chromosome 2 open reading frame 71	10275	0.14
chr2_40573732_40573883	0.43	SLC8A1	solute carrier family 8 (sodium/calcium exchanger), member 1	83613	0.1
chr7_22854826_22854977	0.43	TOMM7	translocase of outer mitochondrial membrane 7 homolog (yeast)	7062	0.23
chr1_82173200_82173351	0.43	LPHN2	latrophilin 2	7820	0.3
chr4_39116331_39116482	0.43	KLHL5	kelch-like family member 5	11471	0.19
chr2_37687823_37688242	0.43	ENSG00000253078	.	25281	0.21
chr4_26143484_26143734	0.43	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	21468	0.28
chr6_106702782_106702933	0.43	ENSG00000244710	.	28729	0.17
chr3_60728480_60728631	0.42	ENSG00000212211	.	113722	0.07
chr22_36828593_36829238	0.42	ENSG00000252575	.	6056	0.16
chr18_2654403_2655150	0.42	SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1	961	0.5
chr14_56792280_56792431	0.42	TMEM260	transmembrane protein 260	162717	0.04
chr11_128298881_128299249	0.42	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	76224	0.11
chr4_95334230_95334509	0.42	PDLIM5	PDZ and LIM domain 5	38668	0.2
chr16_17498688_17498839	0.41	XYLT1	xylosyltransferase I	65975	0.15
chr14_76289523_76289812	0.41	RP11-270M14.4		13887	0.25
chr18_55802231_55802473	0.41	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	14213	0.25
chr4_72254922_72255073	0.41	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	50227	0.19
chr5_78317290_78317441	0.41	DMGDH	dimethylglycine dehydrogenase	32698	0.16

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1	0.3	GO:0071692	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.3	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.3	GO:0009158	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.1	0.2	GO:0007343	egg activation(GO:0007343)
0.1	0.3	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.1	0.2	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.1	0.2	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.1	0.3	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.4	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1	0.4	GO:0015871	choline transport(GO:0015871)
0.1	0.2	GO:0044415	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.2	GO:0090400	stress-induced premature senescence(GO:0090400)
0.1	0.2	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.1	0.4	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1	0.2	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.1	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.4	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.2	GO:0009414	response to water deprivation(GO:0009414)
0.0	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.2	GO:0010560	positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0	0.2	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.2	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.0	GO:0032261	purine nucleotide salvage(GO:0032261)
0.0	0.2	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.4	GO:0031000	response to caffeine(GO:0031000)
0.0	0.1	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.3	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.1	GO:0071372	cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0	0.2	GO:0010758	regulation of macrophage chemotaxis(GO:0010758)
0.0	0.1	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.2	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.4	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.1	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.1	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.1	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.1	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.2	GO:0042756	drinking behavior(GO:0042756)
0.0	0.2	GO:0034260	negative regulation of GTPase activity(GO:0034260)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0070842	aggresome assembly(GO:0070842)
0.0	0.1	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.1	GO:0071288	cellular response to mercury ion(GO:0071288)
0.0	0.1	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.1	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.1	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.0	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.0	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.2	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.1	GO:1903519	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.0	GO:0043096	adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0	0.2	GO:0032462	regulation of protein homooligomerization(GO:0032462)
0.0	0.0	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.1	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0014824	tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.0	0.1	GO:0010225	response to UV-C(GO:0010225)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.0	GO:0048143	astrocyte activation(GO:0048143)
0.0	0.1	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.0	GO:0072182	nephron tubule epithelial cell differentiation(GO:0072160) regulation of nephron tubule epithelial cell differentiation(GO:0072182) regulation of epithelial cell differentiation involved in kidney development(GO:2000696)
0.0	0.1	GO:0090200	positive regulation of mitochondrion organization(GO:0010822) positive regulation of release of cytochrome c from mitochondria(GO:0090200) positive regulation of apoptotic signaling pathway(GO:2001235)
0.0	0.1	GO:0072047	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0031392	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.0	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.3	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.0	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.1	GO:0015868	purine ribonucleotide transport(GO:0015868)
0.0	0.1	GO:0048548	regulation of pinocytosis(GO:0048548)
0.0	0.1	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.0	GO:0050942	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.0	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.1	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.1	GO:0000712	resolution of meiotic recombination intermediates(GO:0000712) meiotic chromosome separation(GO:0051307)
0.0	0.1	GO:0046022	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.1	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.1	GO:0033004	negative regulation of mast cell activation(GO:0033004)
0.0	0.0	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.2	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.0	GO:0010661	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.0	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.2	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.4	GO:0048009	insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.0	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.0	GO:0071800	podosome assembly(GO:0071800)
0.0	0.0	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.0	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0	0.0	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.1	GO:0000239	pachytene(GO:0000239)
0.0	0.0	GO:0071635	negative regulation of transforming growth factor beta production(GO:0071635)
0.0	0.1	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.0	GO:0007549	dosage compensation(GO:0007549)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0015840	urea transport(GO:0015840)
0.0	0.1	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.1	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.4	GO:0042733	embryonic digit morphogenesis(GO:0042733)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.0	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.0	0.1	GO:0043001	Golgi to plasma membrane protein transport(GO:0043001)
0.0	0.0	GO:0072010	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0044319	wound healing, spreading of epidermal cells(GO:0035313) wound healing, spreading of cells(GO:0044319) epiboly(GO:0090504) epiboly involved in wound healing(GO:0090505)
0.0	0.1	GO:0060716	labyrinthine layer blood vessel development(GO:0060716)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.1	GO:0045822	negative regulation of heart contraction(GO:0045822)
0.0	0.0	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0	0.1	GO:0060013	righting reflex(GO:0060013)
0.0	0.0	GO:0051024	positive regulation of immunoglobulin secretion(GO:0051024)
0.0	0.1	GO:0032364	oxygen homeostasis(GO:0032364)
0.0	0.1	GO:0006692	prostanoid metabolic process(GO:0006692)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0042797	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.1	GO:0009111	vitamin catabolic process(GO:0009111) fat-soluble vitamin catabolic process(GO:0042363)
0.0	0.1	GO:0002070	epithelial cell maturation(GO:0002070)
0.0	0.0	GO:0070253	somatostatin secretion(GO:0070253)
0.0	0.0	GO:1904729	regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.0	0.1	GO:0006910	phagocytosis, recognition(GO:0006910)
0.0	0.1	GO:0008210	estrogen metabolic process(GO:0008210)
0.0	0.0	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.0	GO:0030238	male sex determination(GO:0030238)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.0	GO:0048478	replication fork protection(GO:0048478)
0.0	0.0	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.0	GO:0043302	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.3	GO:0015914	phospholipid transport(GO:0015914)
0.0	0.0	GO:0051531	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.0	GO:0048087	positive regulation of developmental pigmentation(GO:0048087)
0.0	0.0	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.1	GO:0061088	regulation of sequestering of zinc ion(GO:0061088)
0.0	0.0	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.0	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.0	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.0	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.3	GO:0006636	unsaturated fatty acid biosynthetic process(GO:0006636)
0.0	0.1	GO:1902603	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.0	GO:0014010	regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) Schwann cell proliferation(GO:0014010)
0.0	0.0	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.0	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:2001021	negative regulation of response to DNA damage stimulus(GO:2001021)
0.0	0.0	GO:0097094	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.1	GO:0006047	UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0	0.0	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0045003	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.4	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.1	0.4	GO:0071437	invadopodium(GO:0071437)
0.1	0.4	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	0.3	GO:0031143	pseudopodium(GO:0031143)
0.0	0.2	GO:0001740	Barr body(GO:0001740)
0.0	0.2	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.2	GO:0033011	perinuclear theca(GO:0033011)
0.0	0.3	GO:0030128	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.2	GO:0016342	catenin complex(GO:0016342)
0.0	0.3	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.3	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.3	GO:0005833	hemoglobin complex(GO:0005833)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.6	GO:0031526	brush border membrane(GO:0031526)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.3	GO:0005581	collagen trimer(GO:0005581)
0.0	0.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.1	GO:0030132	clathrin coat of coated pit(GO:0030132)
0.0	0.2	GO:0043205	fibril(GO:0043205)
0.0	0.2	GO:0030315	T-tubule(GO:0030315)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.6	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0	0.0	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.2	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.2	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.1	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.0	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.0	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.1	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0033162	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.0	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.0	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.0	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.2	GO:0008023	transcription elongation factor complex(GO:0008023)
0.0	0.1	GO:0001917	photoreceptor inner segment(GO:0001917)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.3	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	0.3	GO:0008327	methyl-CpG binding(GO:0008327)
0.1	0.4	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.4	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.1	0.2	GO:0070052	collagen V binding(GO:0070052)
0.1	0.2	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.1	0.2	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.1	0.6	GO:0050780	dopamine receptor binding(GO:0050780)
0.1	0.4	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.1	0.2	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.1	0.2	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.1	0.2	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	0.3	GO:0000828	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.2	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.3	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.2	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.3	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.3	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.2	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.0	0.4	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.5	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.3	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.0	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.2	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.6	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.6	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.2	GO:0016944	obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.0	GO:0030548	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.2	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.0	GO:0002054	nucleobase binding(GO:0002054) purine nucleobase binding(GO:0002060)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0043734	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.3	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.1	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.1	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.2	GO:0005123	death receptor binding(GO:0005123)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.3	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.2	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.0	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.1	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.0	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.1	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.2	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.2	GO:0042301	phosphate ion binding(GO:0042301)
0.0	0.1	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0	0.1	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.0	0.0	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.2	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.4	GO:0005518	collagen binding(GO:0005518)
0.0	0.1	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.0	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.0	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.0	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.1	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.2	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.0	0.0	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0	0.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.0	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.1	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0	0.0	GO:0005534	galactose binding(GO:0005534)
0.0	0.0	GO:0022897	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	0.0	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.7	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.0	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.0	GO:0015137	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.2	GO:0030552	cAMP binding(GO:0030552)
0.0	0.0	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.0	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.0	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.0	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.0	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.0	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.5	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.0	NABA COLLAGENS	Genes encoding collagen proteins
0.8	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	PID IGF1 PATHWAY	IGF1 pathway
0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.1	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.2	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	PID S1P S1P1 PATHWAY	S1P1 pathway
0.6	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.5	PID FGF PATHWAY	FGF signaling pathway
0.1	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.2	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	0.1	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling
0.0	0.4	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.5	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.1	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.0	0.4	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.3	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.3	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.6	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.5	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.0	0.2	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.6	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	0.3	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	0.0	REACTOME EARLY PHASE OF HIV LIFE CYCLE	Genes involved in Early Phase of HIV Life Cycle
0.0	0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.1	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.0	1.0	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.0	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.0	0.5	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.2	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.1	REACTOME PROLONGED ERK ACTIVATION EVENTS	Genes involved in Prolonged ERK activation events
0.0	0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.1	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.0	0.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.1	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.3	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.0	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.0	0.2	REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	Genes involved in Integrin alphaIIb beta3 signaling