Project
ENCODE: H3K4me1 ChIP-Seq of primary human cells
Navigation
Downloads
Logo

Results for SRF

Z-value: 1.68

Motif logo

logo of

Transcription factors associated with SRF

Gene Symbol Gene ID Gene Info
SRF
ENSG00000112658.6 serum response factor

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr6_43138501_43138804SRF3850.786329-0.646.3e-02Click!
chr6_43140630_43141425SRF8990.462382-0.511.6e-01Click!
chr6_43141521_43141708SRF14860.2878440.511.6e-01Click!
chr6_43142607_43142932SRF26410.179829-0.501.7e-01Click!
chr6_43138020_43138466SRF7940.515173-0.462.1e-01Click!

Activity of the SRF motif across conditions

Conditions sorted by the z-value of the SRF motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr10_71950232_71950471 0.99 SAR1A
 SAR1 homolog A (S. cerevisiae)
 20072
 0.17
chr11_111391090_111391372 0.99 C11orf88
 chromosome 11 open reading frame 88
 5721
 0.11
chr7_46297529_46297680 0.93 ENSG00000239004
 .
 282567
 0.01
chr19_13142471_13142622 0.88 NFIX
 nuclear factor I/X (CCAAT-binding transcription factor)
 6735
 0.11
chr6_35457763_35458156 0.86 TEAD3
 TEA domain family member 3
 6768
 0.17
chr10_112170567_112171063 0.86 ENSG00000221359
 .
 23184
 0.2
chr15_51602118_51602364 0.84 CYP19A1
 cytochrome P450, family 19, subfamily A, polypeptide 1
 8448
 0.17
chr1_202003645_202003796 0.84 RP11-510N19.5
23222
 0.1
chr4_47527226_47527524 0.83 AC092597.3
34901
 0.16
chr10_95195819_95196061 0.82 MYOF
 myoferlin
 46011
 0.14
chr6_136399735_136399886 0.79 RP13-143G15.3
5845
 0.27
chr2_122121802_122122094 0.77 CLASP1
 cytoplasmic linker associated protein 1
 63098
 0.13
chr9_138952025_138952443 0.74 NACC2
 NACC family member 2, BEN and BTB (POZ) domain containing
 9808
 0.22
chr12_111873433_111874308 0.74 SH2B3
 SH2B adaptor protein 3
 1204
 0.47
chr3_112323833_112324096 0.74 CCDC80
 coiled-coil domain containing 80
 5163
 0.24
chrY_2545355_2545506 0.74 ENSG00000251841
 .
 107360
 0.07
chrX_2595353_2595504 0.73 CD99
 CD99 molecule
 13792
 0.22
chr11_130767618_130767831 0.73 SNX19
 sorting nexin 19
 3955
 0.35
chr2_173860682_173860978 0.73 RAPGEF4
 Rap guanine nucleotide exchange factor (GEF) 4
 30524
 0.2
chr5_43294641_43294792 0.71 CTD-2636A23.2
5219
 0.23
chr5_141998017_141998291 0.71 FGF1
 fibroblast growth factor 1 (acidic)
 2753
 0.29
chr2_85504705_85504985 0.71 ENSG00000221579
 .
 21312
 0.12
chr14_53330178_53330329 0.70 FERMT2
 fermitin family member 2
 986
 0.61
chr4_26050932_26051083 0.70 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 114070
 0.07
chr8_96814534_96814685 0.70 ENSG00000223297
 .
 123466
 0.06
chr4_141860055_141860206 0.69 RNF150
 ring finger protein 150
 58060
 0.15
chr2_33382763_33382914 0.68 LTBP1
 latent transforming growth factor beta binding protein 1
 23114
 0.25
chr5_119876090_119876241 0.68 PRR16
 proline rich 16
 9006
 0.32
chr2_23634355_23634506 0.67 KLHL29
 kelch-like family member 29
 26342
 0.26
chr15_51401320_51401471 0.67 TNFAIP8L3
 tumor necrosis factor, alpha-induced protein 8-like 3
 3922
 0.27
chr9_74599531_74599682 0.67 C9orf85
 chromosome 9 open reading frame 85
 73029
 0.09
chr7_2802071_2802373 0.67 GNA12
 guanine nucleotide binding protein (G protein) alpha 12
 552
 0.83
chr17_73075198_73075684 0.67 SLC16A5
 solute carrier family 16 (monocarboxylate transporter), member 5
 8381
 0.09
chr14_59800029_59800257 0.67 ENSG00000252869
 .
 66598
 0.11
chr18_20872031_20872182 0.67 RP11-17J14.2
31788
 0.2
chr8_26123678_26123924 0.66 PPP2R2A
 protein phosphatase 2, regulatory subunit B, alpha
 25206
 0.23
chr1_219259694_219259888 0.66 LYPLAL1
 lysophospholipase-like 1
 87395
 0.1
chr2_202999119_202999270 0.66 AC079354.3
17413
 0.15
chr4_95470032_95470452 0.66 PDLIM5
 PDZ and LIM domain 5
 25366
 0.27
chr6_132452737_132452888 0.66 ENSG00000265669
 .
 16409
 0.27
chr11_76327363_76327514 0.66 AP001189.4
40662
 0.14
chr1_68306464_68306615 0.65 GNG12
 guanine nucleotide binding protein (G protein), gamma 12
 7389
 0.22
chr2_36659694_36659845 0.65 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 76155
 0.1
chr17_64419381_64419532 0.65 RP11-4F22.2
6484
 0.26
chr1_185941378_185941529 0.65 HMCN1
 hemicentin 1
 199066
 0.03
chr2_227276660_227276915 0.65 ENSG00000263363
 .
 246722
 0.02
chr8_41570885_41571036 0.64 ANK1
 ankyrin 1, erythrocytic
 7263
 0.19
chr11_130273396_130273575 0.64 ADAMTS8
 ADAM metallopeptidase with thrombospondin type 1 motif, 8
 25403
 0.2
chr16_83723296_83723447 0.64 RP11-298D21.3
28132
 0.16
chr15_90121530_90121681 0.64 TICRR
 TOPBP1-interacting checkpoint and replication regulator
 2787
 0.21
chr15_70995885_70996036 0.64 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 346
 0.92
chr2_36639522_36639673 0.62 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 55983
 0.15
chr2_20001512_20001663 0.61 TTC32
 tetratricopeptide repeat domain 32
 99815
 0.08
chr3_160191590_160191741 0.61 ENSG00000238427
 .
 1461
 0.35
chr12_6338128_6338295 0.61 ENSG00000202318
 .
 5410
 0.19
chr18_56664990_56665141 0.61 ENSG00000251870
 .
 71537
 0.1
chr13_32662235_32662386 0.61 FRY
 furry homolog (Drosophila)
 27309
 0.22
chr1_95332085_95332236 0.61 SLC44A3
 solute carrier family 44, member 3
 727
 0.68
chr1_59482045_59482243 0.60 JUN
 jun proto-oncogene
 232359
 0.02
chr4_151201855_151202006 0.60 LRBA
 LPS-responsive vesicle trafficking, beach and anchor containing
 21933
 0.25
chr15_83874173_83874324 0.60 HDGFRP3
 Hepatoma-derived growth factor-related protein 3
 2522
 0.27
chr12_117302328_117302479 0.60 HRK
 harakiri, BCL2 interacting protein (contains only BH3 domain)
 16490
 0.21
chr16_64443886_64444184 0.60 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 649546
 0.0
chr1_178908514_178908665 0.60 RALGPS2
 Ral GEF with PH domain and SH3 binding motif 2
 53375
 0.13
chr17_46559333_46559484 0.60 ENSG00000206805
 .
 2949
 0.17
chr6_160123078_160123229 0.59 SOD2
 superoxide dismutase 2, mitochondrial
 8793
 0.15
chr18_57488970_57489121 0.59 ENSG00000221471
 .
 72136
 0.1
chr9_116940584_116940813 0.59 COL27A1
 collagen, type XXVII, alpha 1
 10703
 0.21
chr1_245928780_245928931 0.59 RP11-522M21.3
89075
 0.09
chr5_14193033_14193184 0.59 TRIO
 trio Rho guanine nucleotide exchange factor
 9201
 0.32
chr7_134592506_134592657 0.58 CALD1
 caldesmon 1
 12656
 0.27
chr11_73849202_73849353 0.58 C2CD3
 C2 calcium-dependent domain containing 3
 32752
 0.14
chr3_58975517_58975668 0.58 C3orf67
 chromosome 3 open reading frame 67
 52104
 0.18
chr11_102026582_102026733 0.58 YAP1
 Yes-associated protein 1
 30155
 0.15
chr2_24051637_24051788 0.57 ATAD2B
 ATPase family, AAA domain containing 2B
 3769
 0.31
chr5_34686863_34687019 0.57 RAI14
 retinoic acid induced 14
 451
 0.87
chr21_46880431_46880582 0.57 COL18A1
 collagen, type XVIII, alpha 1
 5082
 0.21
chr5_61440086_61440237 0.57 ENSG00000251983
 .
 2331
 0.45
chr11_61656018_61656169 0.57 FADS3
 fatty acid desaturase 3
 2290
 0.2
chr3_194296927_194297078 0.57 TMEM44-AS1
 TMEM44 antisense RNA 1
 7738
 0.15
chr5_177975146_177975297 0.56 COL23A1
 collagen, type XXIII, alpha 1
 14018
 0.22
chr7_41045186_41045337 0.56 AC005160.3
230104
 0.02
chr16_69238182_69238401 0.56 ENSG00000200164
 .
 13265
 0.12
chr15_35598915_35599148 0.56 ENSG00000265102
 .
 65534
 0.14
chr11_13156552_13156703 0.56 ARNTL
 aryl hydrocarbon receptor nuclear translocator-like
 141572
 0.04
chr6_86173167_86173318 0.56 NT5E
 5'-nucleotidase, ecto (CD73)
 7857
 0.27
chr20_43223275_43223491 0.56 PKIG
 protein kinase (cAMP-dependent, catalytic) inhibitor gamma
 12193
 0.15
chr1_154163009_154163193 0.56 TPM3
 tropomyosin 3
 1433
 0.23
chr2_213708215_213708366 0.55 ENSG00000221388
 .
 79891
 0.1
chr17_53504679_53504830 0.55 MMD
 monocyte to macrophage differentiation-associated
 5401
 0.32
chr12_66050940_66051359 0.55 HMGA2
 high mobility group AT-hook 2
 166762
 0.03
chr5_146910957_146911108 0.55 DPYSL3
 dihydropyrimidinase-like 3
 21413
 0.26
chr7_127417436_127417587 0.55 SND1
 staphylococcal nuclease and tudor domain containing 1
 110454
 0.06
chr18_33746577_33746728 0.54 RP11-49I11.1
20759
 0.16
chr18_43363682_43364023 0.54 RP11-116O18.3
36672
 0.14
chr3_23536791_23536942 0.54 ENSG00000265645
 .
 14797
 0.26
chr1_17963278_17963429 0.53 ARHGEF10L
 Rho guanine nucleotide exchange factor (GEF) 10-like
 18504
 0.26
chr13_97925911_97926062 0.53 MBNL2
 muscleblind-like splicing regulator 2
 2472
 0.41
chr5_16913937_16914088 0.53 MYO10
 myosin X
 2624
 0.32
chr10_101671643_101671794 0.53 DNMBP
 dynamin binding protein
 2121
 0.33
chr11_35562990_35563282 0.53 PAMR1
 peptidase domain containing associated with muscle regeneration 1
 11288
 0.25
chr20_8203734_8203885 0.52 PLCB1-IT1
 PLCB1 intronic transcript 1 (non-protein coding)
 25542
 0.25
chr2_27543666_27543963 0.52 MPV17
 MpV17 mitochondrial inner membrane protein
 1617
 0.19
chr13_110971974_110972125 0.52 COL4A2
 collagen, type IV, alpha 2
 12435
 0.21
chr3_143774181_143774332 0.52 C3orf58
 chromosome 3 open reading frame 58
 81806
 0.11
chr6_144570022_144570173 0.52 UTRN
 utrophin
 36740
 0.19
chr9_21837231_21837382 0.52 MTAP
 methylthioadenosine phosphorylase
 17417
 0.17
chr4_126309256_126309407 0.52 FAT4
 FAT atypical cadherin 4
 5760
 0.29
chr2_214052779_214052930 0.52 IKZF2
 IKAROS family zinc finger 2 (Helios)
 35703
 0.22
chr5_155564195_155564346 0.52 SGCD
 sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
 189486
 0.03
chr4_81228117_81228268 0.51 C4orf22
 chromosome 4 open reading frame 22
 28682
 0.2
chr14_55768736_55768887 0.51 FBXO34
 F-box protein 34
 29939
 0.18
chr17_56031434_56032135 0.51 CUEDC1
 CUE domain containing 1
 834
 0.58
chr9_97758309_97758460 0.51 C9orf3
 chromosome 9 open reading frame 3
 8031
 0.21
chr3_185531728_185531979 0.51 IGF2BP2
 insulin-like growth factor 2 mRNA binding protein 2
 6996
 0.24
chr1_32819059_32819503 0.51 TSSK3
 testis-specific serine kinase 3
 226
 0.89
chr10_30151041_30151192 0.51 SVIL
 supervillin
 126383
 0.05
chr15_33121833_33121984 0.50 FMN1
 formin 1
 58547
 0.12
chr12_54414078_54414229 0.50 HOXC4
 homeobox C4
 3438
 0.08
chr16_87136109_87136260 0.50 RP11-899L11.3
113337
 0.06
chr1_214689137_214689772 0.50 PTPN14
 protein tyrosine phosphatase, non-receptor type 14
 35112
 0.22
chr6_42067452_42067603 0.50 C6orf132
 chromosome 6 open reading frame 132
 42655
 0.1
chr6_44040423_44041032 0.49 RP5-1120P11.1
1662
 0.35
chr3_149180351_149180502 0.49 TM4SF4
 transmembrane 4 L six family member 4
 11335
 0.21
chr12_43709758_43710210 0.49 ENSG00000215993
 .
 24601
 0.27
chr5_153003397_153003548 0.49 ENSG00000242976
 .
 131470
 0.05
chr15_33093451_33093719 0.49 GREM1
 gremlin 1, DAN family BMP antagonist
 70693
 0.09
chr8_69837050_69837201 0.49 ENSG00000238808
 .
 185684
 0.03
chr9_111397417_111397568 0.48 ACTL7B
 actin-like 7B
 221747
 0.02
chr6_2468842_2468993 0.48 ENSG00000266252
 .
 59048
 0.15
chr12_79943500_79943651 0.48 ENSG00000243714
 .
 24625
 0.19
chr19_39150000_39150519 0.48 ACTN4
 actinin, alpha 4
 11881
 0.12
chr12_52167059_52167210 0.48 AC068987.1
 HCG1997999; cDNA FLJ33996 fis, clone DFNES2008881
 36655
 0.17
chr9_36332681_36332832 0.48 GNE
 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
 55703
 0.12
chr12_16505710_16505975 0.47 MGST1
 microsomal glutathione S-transferase 1
 509
 0.85
chr7_104607919_104608070 0.47 ENSG00000251911
 .
 3740
 0.23
chr20_1800907_1801169 0.47 SIRPA
 signal-regulatory protein alpha
 74116
 0.1
chr8_32962851_32963002 0.47 ENSG00000265562
 .
 90429
 0.09
chr3_188669250_188669401 0.47 TPRG1
 tumor protein p63 regulated 1
 4322
 0.37
chr12_91577880_91578031 0.47 DCN
 decorin
 1055
 0.66
chr5_158477621_158478266 0.47 EBF1
 early B-cell factor 1
 48758
 0.14
chr6_145569007_145569263 0.47 ENSG00000221796
 .
 100759
 0.09
chr3_184918393_184918544 0.47 EHHADH-AS1
 EHHADH antisense RNA 1
 37779
 0.14
chr18_395353_395504 0.46 RP11-720L2.2
28988
 0.2
chr8_79844807_79844958 0.46 IL7
 interleukin 7
 127124
 0.06
chr4_14112329_14112480 0.46 ENSG00000252092
 .
 452153
 0.01
chr1_68640592_68640743 0.46 ENSG00000221203
 .
 8626
 0.22
chr5_81561436_81561587 0.46 RPS23
 ribosomal protein S23
 12649
 0.23
chr10_6243827_6244661 0.46 RP11-414H17.5
412
 0.58
chr7_22630355_22630506 0.46 AC002480.4
1106
 0.52
chr12_104253506_104253657 0.46 RP11-650K20.3
 Uncharacterized protein
 18352
 0.14
chr22_35842229_35842380 0.46 MCM5
 minichromosome maintenance complex component 5
 45880
 0.14
chr5_121518992_121519276 0.46 CTC-441N14.1
27424
 0.17
chr4_26371195_26371346 0.46 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 7118
 0.32
chr2_1576886_1577037 0.46 AC144450.1
46924
 0.17
chr5_135390329_135390480 0.46 TGFBI
 transforming growth factor, beta-induced, 68kDa
 4134
 0.24
chr6_88416816_88416967 0.46 AKIRIN2
 akirin 2
 4964
 0.22
chr11_94809865_94810123 0.46 ENDOD1
 endonuclease domain containing 1
 12980
 0.21
chr8_74282582_74282920 0.46 RP11-434I12.2
14055
 0.25
chr14_75688690_75688954 0.45 ENSG00000252013
 .
 19950
 0.14
chr6_113198313_113198464 0.45 ENSG00000201386
 .
 94307
 0.09
chr8_69991685_69991836 0.45 ENSG00000238808
 .
 31049
 0.26
chr3_27610112_27610263 0.45 ENSG00000238912
 .
 20838
 0.22
chr9_12880763_12880914 0.45 ENSG00000222658
 .
 4482
 0.3
chr10_30800294_30800445 0.45 ENSG00000239744
 .
 44464
 0.15
chr20_43696508_43696659 0.45 KCNS1
 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
 33167
 0.12
chr3_174985020_174985171 0.44 NAALADL2-AS2
 NAALADL2 antisense RNA 2
 3790
 0.34
chr2_36932543_36932694 0.44 VIT
 vitrin
 8598
 0.25
chr14_65148512_65148745 0.44 PLEKHG3
 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
 22192
 0.19
chr3_16145872_16146023 0.44 GALNT15
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
 70209
 0.12
chr13_94997091_94997242 0.44 ENSG00000212057
 .
 120478
 0.06
chr14_71709495_71709775 0.44 AC004817.1
 HCG2028611; Uncharacterized protein
 26173
 0.21
chr14_73212557_73212708 0.44 ENSG00000206751
 .
 107407
 0.07
chr6_86155572_86155723 0.44 NT5E
 5'-nucleotidase, ecto (CD73)
 4162
 0.33
chr13_98508497_98508648 0.44 ENSG00000238407
 .
 29491
 0.24
chr16_64126268_64126419 0.43 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 967238
 0.0
chr13_27454838_27454989 0.43 GPR12
 G protein-coupled receptor 12
 119991
 0.06
chr22_44707279_44707430 0.43 KIAA1644
 KIAA1644
 1377
 0.54
chr18_66106660_66106811 0.43 TMX3
 thioredoxin-related transmembrane protein 3
 275559
 0.02
chr8_129553232_129553525 0.43 ENSG00000221351
 .
 278662
 0.01
chr10_100134588_100134739 0.43 ENSG00000221419
 .
 20401
 0.18
chr2_29286777_29286928 0.43 C2orf71
 chromosome 2 open reading frame 71
 10275
 0.14
chr2_40573732_40573883 0.43 SLC8A1
 solute carrier family 8 (sodium/calcium exchanger), member 1
 83613
 0.1
chr7_22854826_22854977 0.43 TOMM7
 translocase of outer mitochondrial membrane 7 homolog (yeast)
 7062
 0.23
chr1_82173200_82173351 0.43 LPHN2
 latrophilin 2
 7820
 0.3
chr4_39116331_39116482 0.43 KLHL5
 kelch-like family member 5
 11471
 0.19
chr2_37687823_37688242 0.43 ENSG00000253078
 .
 25281
 0.21
chr4_26143484_26143734 0.43 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 21468
 0.28
chr6_106702782_106702933 0.43 ENSG00000244710
 .
 28729
 0.17
chr3_60728480_60728631 0.42 ENSG00000212211
 .
 113722
 0.07
chr22_36828593_36829238 0.42 ENSG00000252575
 .
 6056
 0.16
chr18_2654403_2655150 0.42 SMCHD1
 structural maintenance of chromosomes flexible hinge domain containing 1
 961
 0.5
chr14_56792280_56792431 0.42 TMEM260
 transmembrane protein 260
 162717
 0.04
chr11_128298881_128299249 0.42 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 76224
 0.11
chr4_95334230_95334509 0.42 PDLIM5
 PDZ and LIM domain 5
 38668
 0.2
chr16_17498688_17498839 0.41 XYLT1
 xylosyltransferase I
 65975
 0.15
chr14_76289523_76289812 0.41 RP11-270M14.4
13887
 0.25
chr18_55802231_55802473 0.41 NEDD4L
 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
 14213
 0.25
chr4_72254922_72255073 0.41 SLC4A4
 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
 50227
 0.19
chr5_78317290_78317441 0.41 DMGDH
 dimethylglycine dehydrogenase
 32698
 0.16

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.3 GO:0071692 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.3 GO:0009158 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.1 0.2 GO:0007343 egg activation(GO:0007343)
0.1 0.3 GO:0032431 activation of phospholipase A2 activity(GO:0032431)
0.1 0.2 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.1 0.2 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.1 0.3 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.4 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1 0.4 GO:0015871 choline transport(GO:0015871)
0.1 0.2 GO:0044415 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 0.2 GO:0090400 stress-induced premature senescence(GO:0090400)
0.1 0.2 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.1 0.4 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 0.2 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.4 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.2 GO:0009414 response to water deprivation(GO:0009414)
0.0 0.2 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.2 GO:0010560 positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.2 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.0 GO:0032261 purine nucleotide salvage(GO:0032261)
0.0 0.2 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.4 GO:0031000 response to caffeine(GO:0031000)
0.0 0.1 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.3 GO:0046655 folic acid metabolic process(GO:0046655)
0.0 0.1 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.2 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.1 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0 0.1 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.2 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.4 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.1 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0 0.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.2 GO:0042756 drinking behavior(GO:0042756)
0.0 0.2 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.1 GO:0070842 aggresome assembly(GO:0070842)
0.0 0.1 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.1 GO:0071288 cellular response to mercury ion(GO:0071288)
0.0 0.1 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.1 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0 0.1 GO:0006927 obsolete transformed cell apoptotic process(GO:0006927)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.0 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 0.0 GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.1 GO:0001821 histamine secretion(GO:0001821)
0.0 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.1 GO:1903519 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.0 GO:0043096 adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0 0.2 GO:0032462 regulation of protein homooligomerization(GO:0032462)
0.0 0.0 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.0 0.1 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0014824 tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.0 0.1 GO:0010225 response to UV-C(GO:0010225)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.0 GO:0048143 astrocyte activation(GO:0048143)
0.0 0.1 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
0.0 0.0 GO:0072182 nephron tubule epithelial cell differentiation(GO:0072160) regulation of nephron tubule epithelial cell differentiation(GO:0072182) regulation of epithelial cell differentiation involved in kidney development(GO:2000696)
0.0 0.1 GO:0090200 positive regulation of mitochondrion organization(GO:0010822) positive regulation of release of cytochrome c from mitochondria(GO:0090200) positive regulation of apoptotic signaling pathway(GO:2001235)
0.0 0.1 GO:0072047 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0031392 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.0 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.0 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.3 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 0.0 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.0 0.1 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 0.1 GO:0048548 regulation of pinocytosis(GO:0048548)
0.0 0.1 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.0 0.0 GO:0050942 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.0 GO:0055089 fatty acid homeostasis(GO:0055089)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712) meiotic chromosome separation(GO:0051307)
0.0 0.1 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.1 GO:0006007 glucose catabolic process(GO:0006007)
0.0 0.1 GO:0033004 negative regulation of mast cell activation(GO:0033004)
0.0 0.0 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0 0.0 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.2 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.0 GO:0010661 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.0 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.2 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.4 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.0 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.0 GO:0071800 podosome assembly(GO:0071800)
0.0 0.0 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.1 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.0 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.0 GO:0021570 rhombomere 4 development(GO:0021570)
0.0 0.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0000239 pachytene(GO:0000239)
0.0 0.0 GO:0071635 negative regulation of transforming growth factor beta production(GO:0071635)
0.0 0.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.0 GO:0007549 dosage compensation(GO:0007549)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0015840 urea transport(GO:0015840)
0.0 0.1 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.4 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 0.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.0 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.1 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.0 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.1 GO:0044319 wound healing, spreading of epidermal cells(GO:0035313) wound healing, spreading of cells(GO:0044319) epiboly(GO:0090504) epiboly involved in wound healing(GO:0090505)
0.0 0.1 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.0 0.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.1 GO:0045822 negative regulation of heart contraction(GO:0045822)
0.0 0.0 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0 0.1 GO:0060013 righting reflex(GO:0060013)
0.0 0.0 GO:0051024 positive regulation of immunoglobulin secretion(GO:0051024)
0.0 0.1 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 0.1 GO:0006692 prostanoid metabolic process(GO:0006692)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.1 GO:0009111 vitamin catabolic process(GO:0009111) fat-soluble vitamin catabolic process(GO:0042363)
0.0 0.1 GO:0002070 epithelial cell maturation(GO:0002070)
0.0 0.0 GO:0070253 somatostatin secretion(GO:0070253)
0.0 0.0 GO:1904729 regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.0 0.1 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 0.0 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 0.0 GO:0030238 male sex determination(GO:0030238)
0.0 0.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.0 GO:0048478 replication fork protection(GO:0048478)
0.0 0.0 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 0.0 GO:0043302 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.3 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.0 GO:0051531 NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0 0.0 GO:0048087 positive regulation of developmental pigmentation(GO:0048087)
0.0 0.0 GO:0031558 obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0 0.1 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.0 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.0 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.0 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.0 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.3 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.0 0.1 GO:1902603 carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0 0.0 GO:0014010 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) Schwann cell proliferation(GO:0014010)
0.0 0.0 GO:0001866 NK T cell proliferation(GO:0001866)
0.0 0.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.1 GO:2001021 negative regulation of response to DNA damage stimulus(GO:2001021)
0.0 0.0 GO:0097094 cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.1 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0 0.0 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.1 GO:0045003 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 0.4 GO:0071437 invadopodium(GO:0071437)
0.1 0.4 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0001740 Barr body(GO:0001740)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.2 GO:0033011 perinuclear theca(GO:0033011)
0.0 0.3 GO:0030128 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.3 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.6 GO:0031526 brush border membrane(GO:0031526)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 0.2 GO:0043205 fibril(GO:0043205)
0.0 0.2 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.6 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.0 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.2 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 0.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.0 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.1 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.1 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.0 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0 0.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0001917 photoreceptor inner segment(GO:0001917)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.4 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.4 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.1 0.2 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 0.2 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.1 0.6 GO:0050780 dopamine receptor binding(GO:0050780)
0.1 0.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.2 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 0.2 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.3 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0 0.3 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.1 GO:0004645 phosphorylase activity(GO:0004645)
0.0 0.3 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.1 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.2 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.5 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.2 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0016944 obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0 0.2 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.0 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.0 GO:0002054 nucleobase binding(GO:0002054) purine nucleobase binding(GO:0002060)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.1 GO:0043734 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.2 GO:0005123 death receptor binding(GO:0005123)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.3 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.2 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.0 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.0 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.1 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 0.2 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.0 0.0 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.0 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.0 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.0 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.0 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.1 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.2 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.0 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.0 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.0 GO:0005534 galactose binding(GO:0005534)
0.0 0.0 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.0 GO:0008518 reduced folate carrier activity(GO:0008518)
0.0 0.0 GO:0015137 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.2 GO:0030552 cAMP binding(GO:0030552)
0.0 0.0 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.0 GO:0045545 syndecan binding(GO:0045545)
0.0 0.0 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0 0.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.0 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.0 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.0 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.0 PID IGF1 PATHWAY IGF1 pathway
0.0 0.1 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.1 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.1 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.2 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.3 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.1 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.6 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.5 PID FGF PATHWAY FGF signaling pathway
0.0 0.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.2 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.1 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.0 0.4 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.0 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.2 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.6 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.0 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.1 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.0 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.5 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.0 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.1 REACTOME PROLONGED ERK ACTIVATION EVENTS Genes involved in Prolonged ERK activation events
0.0 0.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.1 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.0 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.0 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.2 REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING Genes involved in Integrin alphaIIb beta3 signaling