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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for STAT4

Z-value: 1.20

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Transcription factors associated with STAT4

Gene Symbol	Gene ID	Gene Info
STAT4 Ensembl NCBI GeneCards UniProt	ENSG00000138378.13	STAT4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
STAT4	chr2_192013340_192013491	2282	0.339131	0.66	5.3e-02	Click!
STAT4	chr2_192016485_192016636	238	0.941695	0.56	1.2e-01	Click!
STAT4	chr2_192056884_192057039	40639	0.156524	-0.49	1.8e-01	Click!
STAT4	chr2_192012454_192012731	3105	0.286995	0.48	1.9e-01	Click!
STAT4	chr2_192037184_192037335	20937	0.205608	-0.45	2.2e-01	Click!

Activity of the STAT4 motif across conditions

Conditions sorted by the z-value of the STAT4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_136013025_136013297	0.45	RALGDS	ral guanine nucleotide dissociation stimulator	6657	0.15
chr14_75038764_75038974	0.41	LTBP2	latent transforming growth factor beta binding protein 2	39906	0.13
chr5_156621341_156621645	0.39	ITK	IL2-inducible T-cell kinase	13656	0.12
chr1_66518298_66518449	0.37	RP11-397C12.1		1972	0.41
chr7_24940112_24940263	0.35	ENSG00000238976	.	244	0.94
chr1_90097018_90097733	0.34	RP5-1007M22.2		375	0.77
chr1_112059507_112059886	0.32	ADORA3	adenosine A3 receptor	13314	0.12
chr12_12647697_12647848	0.30	DUSP16	dual specificity phosphatase 16	26287	0.21
chr7_3102888_3103135	0.30	CARD11	caspase recruitment domain family, member 11	19432	0.23
chr4_109015585_109015736	0.29	LEF1	lymphoid enhancer-binding factor 1	71797	0.1
chr7_144516745_144516896	0.29	TPK1	thiamin pyrophosphokinase 1	16326	0.24
chr13_43149418_43149818	0.29	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	1258	0.64
chr18_35289879_35290030	0.28	ENSG00000266530	.	52856	0.18
chr4_122111518_122111869	0.28	ENSG00000252183	.	2365	0.34
chr5_156953479_156953635	0.28	ADAM19	ADAM metallopeptidase domain 19	23727	0.15
chr6_159228545_159229058	0.28	EZR-AS1	EZR antisense RNA 1	10242	0.17
chr10_115610846_115611146	0.27	DCLRE1A	DNA cross-link repair 1A	2863	0.22
chr1_112192925_112193076	0.27	ENSG00000201028	.	159	0.95
chr6_25036886_25037064	0.26	RP3-425P12.5		5092	0.19
chr3_31504876_31505139	0.26	ENSG00000238727	.	67578	0.12
chr7_75248927_75249078	0.26	HIP1	huntingtin interacting protein 1	7841	0.2
chr7_21391785_21392069	0.26	ENSG00000195024	.	29054	0.2
chr14_63670641_63670908	0.26	RHOJ	ras homolog family member J	352	0.91
chr15_60863549_60863700	0.26	RORA	RAR-related orphan receptor A	21116	0.19
chr2_28836401_28836726	0.26	PLB1	phospholipase B1	11777	0.21
chr18_22242340_22242491	0.25	HRH4	histamine receptor H4	201722	0.02
chr11_126336020_126336230	0.25	KIRREL3	kin of IRRE like 3 (Drosophila)	25672	0.18
chr14_38540644_38540853	0.24	CTD-2058B24.2		19615	0.24
chr1_167468557_167468835	0.24	CD247	CD247 molecule	19079	0.18
chr17_37937298_37937847	0.24	IKZF3	IKAROS family zinc finger 3 (Aiolos)	3094	0.19
chr3_113250406_113250557	0.24	SIDT1	SID1 transmembrane family, member 1	662	0.69
chr4_143634715_143634901	0.24	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	132635	0.06
chr2_68948486_68948822	0.24	ARHGAP25	Rho GTPase activating protein 25	11020	0.25
chr20_30392262_30392413	0.24	MYLK2	myosin light chain kinase 2	14774	0.14
chr7_17068483_17068634	0.24	AGR3	anterior gradient 3	146947	0.04
chr2_42352864_42353761	0.24	EML4	echinoderm microtubule associated protein like 4	43178	0.15
chr13_99209848_99210037	0.23	STK24	serine/threonine kinase 24	19175	0.2
chr10_21807546_21807797	0.23	SKIDA1	SKI/DACH domain containing 1	823	0.52
chr3_17341812_17341972	0.23	TBC1D5	TBC1 domain family, member 5	106320	0.08
chr3_196291691_196292106	0.23	WDR53	WD repeat domain 53	2283	0.21
chr15_38976681_38977159	0.23	C15orf53	chromosome 15 open reading frame 53	11879	0.28
chr4_186173181_186173380	0.23	SNX25	sorting nexin 25	42047	0.13
chr21_34302222_34302373	0.23	AP000281.2		80053	0.07
chr1_206942223_206942745	0.23	IL10	interleukin 10	3355	0.2
chr3_53072289_53072451	0.23	SFMBT1	Scm-like with four mbt domains 1	6911	0.19
chr20_57735088_57735478	0.23	ZNF831	zinc finger protein 831	30792	0.19
chr2_55193973_55194124	0.23	RTN4	reticulon 4	43537	0.15
chr1_197737430_197737581	0.23	DENND1B	DENN/MADD domain containing 1B	6817	0.23
chr15_64454533_64454724	0.23	PPIB	peptidylprolyl isomerase B (cyclophilin B)	776	0.59
chr19_47935849_47936000	0.22	MEIS3	Meis homeobox 3	13144	0.14
chr2_204854148_204854486	0.22	ICOS	inducible T-cell co-stimulator	52814	0.17
chr3_45983815_45984178	0.22	CXCR6	chemokine (C-X-C motif) receptor 6	968	0.5
chr16_67018785_67019348	0.22	CES4A	carboxylesterase 4A	3426	0.14
chr17_71588187_71588481	0.22	RP11-277J6.2		48831	0.13
chr11_18640352_18640885	0.22	SPTY2D1	SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)	15422	0.14
chr3_50609823_50610526	0.21	C3orf18	chromosome 3 open reading frame 18	1752	0.28
chr14_22627506_22627657	0.21	ENSG00000238634	.	16694	0.27
chr16_87495374_87495580	0.21	ZCCHC14	zinc finger, CCHC domain containing 14	28737	0.15
chr14_50437257_50437517	0.21	C14orf182	chromosome 14 open reading frame 182	36851	0.12
chr20_49168238_49168495	0.21	ENSG00000239742	.	6169	0.15
chr9_121284831_121284982	0.21	ENSG00000251847	.	791157	0.0
chr5_75622593_75622811	0.21	RP11-466P24.6		15415	0.26
chr9_101854958_101855213	0.21	TGFBR1	transforming growth factor, beta receptor 1	11235	0.23
chr10_18069015_18069166	0.21	TMEM236		27863	0.17
chr8_67452033_67452620	0.21	ENSG00000206949	.	38780	0.13
chr22_36558393_36558682	0.21	APOL3	apolipoprotein L, 3	1560	0.43
chr11_118109252_118109403	0.20	AMICA1	adhesion molecule, interacts with CXADR antigen 1	13518	0.13
chr19_11085110_11085263	0.20	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	9642	0.13
chr10_69371869_69372293	0.20	CTNNA3	catenin (cadherin-associated protein), alpha 3	35190	0.23
chr5_131732657_131732808	0.20	C5orf56	chromosome 5 open reading frame 56	13596	0.12
chr6_130505643_130505870	0.20	SAMD3	sterile alpha motif domain containing 3	29758	0.2
chr10_496561_496809	0.20	RP11-490E15.2		13184	0.2
chr20_33131898_33132049	0.20	MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	2685	0.23
chr8_2078833_2079052	0.20	MYOM2	myomesin 2	85758	0.1
chr1_26031102_26031259	0.20	MAN1C1	mannosidase, alpha, class 1C, member 1	4913	0.2
chr4_116134565_116134716	0.20	NDST4	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	99608	0.09
chr2_225790470_225790675	0.20	DOCK10	dedicator of cytokinesis 10	21210	0.27
chr11_118123821_118123979	0.20	MPZL3	myelin protein zero-like 3	835	0.52
chr7_50431752_50432472	0.19	IKZF1	IKAROS family zinc finger 1 (Ikaros)	64867	0.11
chr1_43399996_43400147	0.19	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	3275	0.24
chr8_59569855_59570006	0.19	NSMAF	neutral sphingomyelinase (N-SMase) activation associated factor	2163	0.35
chr2_64978837_64979534	0.19	ENSG00000253082	.	24053	0.19
chr6_118978234_118978481	0.19	CEP85L	centrosomal protein 85kDa-like	4674	0.33
chr5_75586536_75586687	0.19	RP11-466P24.6		20676	0.26
chr13_74601733_74602123	0.19	KLF12	Kruppel-like factor 12	32742	0.25
chr11_58407663_58407869	0.19	CNTF	ciliary neurotrophic factor	17620	0.14
chr7_72929480_72929631	0.19	BAZ1B	bromodomain adjacent to zinc finger domain, 1B	7047	0.15
chr5_156644620_156644840	0.19	CTB-4E7.1		6660	0.14
chr3_170995564_170995715	0.19	TNIK	TRAF2 and NCK interacting kinase	52139	0.17
chr6_26174520_26174671	0.19	HIST1H2BE	histone cluster 1, H2be	9363	0.06
chr13_43562200_43562351	0.19	EPSTI1	epithelial stromal interaction 1 (breast)	3092	0.34
chr3_56832571_56832900	0.19	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	3242	0.36
chr1_228928769_228929191	0.19	RHOU	ras homolog family member U	58156	0.09
chr6_42008817_42009180	0.19	CCND3	cyclin D3	7426	0.16
chr14_91668757_91668960	0.19	C14orf159	chromosome 14 open reading frame 159	6121	0.19
chr12_104912220_104912483	0.19	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	61572	0.13
chr10_120973836_120973987	0.19	ENSG00000242853	.	1542	0.31
chr22_23190435_23190586	0.19	IGLV3-6	immunoglobulin lambda variable 3-6 (pseudogene)	2040	0.09
chr14_69090040_69090191	0.18	CTD-2325P2.4		5047	0.29
chr1_160535898_160536088	0.18	CD84	CD84 molecule	13270	0.13
chr15_75159560_75159711	0.18	SCAMP2	secretory carrier membrane protein 2	5746	0.12
chr11_12179023_12179437	0.18	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	3760	0.32
chr4_76859668_76859847	0.18	NAAA	N-acylethanolamine acid amidase	1656	0.28
chr12_15715155_15715553	0.18	PTPRO	protein tyrosine phosphatase, receptor type, O	16068	0.26
chr11_67212387_67212841	0.18	CORO1B	coronin, actin binding protein, 1B	1351	0.18
chr16_5022975_5023126	0.18	PPL	periplakin	12308	0.14
chr11_47287617_47287768	0.18	MADD	MAP-kinase activating death domain	3020	0.14
chr5_96341021_96341172	0.18	ENSG00000200884	.	42635	0.13
chr17_62965440_62965774	0.18	AMZ2P1	archaelysin family metallopeptidase 2 pseudogene 1	4028	0.17
chr17_55519809_55520223	0.18	ENSG00000263902	.	30454	0.2
chr1_28525263_28525593	0.18	AL353354.2		1642	0.2
chr14_89632758_89632909	0.18	FOXN3	forkhead box N3	14255	0.28
chr1_39658074_39658238	0.18	MACF1	microtubule-actin crosslinking factor 1	11762	0.17
chr13_25171578_25171729	0.18	ENSG00000211508	.	11564	0.18
chr1_39572189_39572340	0.18	MACF1	microtubule-actin crosslinking factor 1	1181	0.46
chr12_53765461_53765679	0.18	SP1	Sp1 transcription factor	8390	0.12
chr1_100917512_100917831	0.18	RP5-837M10.4		33882	0.17
chr17_40859652_40859819	0.18	CTD-3193K9.3		8251	0.09
chr7_44666023_44666225	0.18	OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	2063	0.32
chr16_68326071_68326222	0.18	ENSG00000252026	.	7925	0.08
chr14_52753608_52753759	0.18	PTGDR	prostaglandin D2 receptor (DP)	19153	0.22
chr8_66913743_66914032	0.18	DNAJC5B	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	19908	0.26
chr7_50302307_50302807	0.18	IKZF1	IKAROS family zinc finger 1 (Ikaros)	41767	0.19
chr4_55543624_55543775	0.18	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	19614	0.29
chr16_50874827_50875162	0.18	ENSG00000199771	.	28492	0.15
chr17_37914078_37914229	0.18	GRB7	growth factor receptor-bound protein 7	15648	0.11
chr5_70884126_70884318	0.18	MCCC2	methylcrotonoyl-CoA carboxylase 2 (beta)	1027	0.62
chr1_26704569_26704720	0.18	ZNF683	zinc finger protein 683	3631	0.15
chr10_98624657_98624808	0.18	LCOR	ligand dependent nuclear receptor corepressor	31995	0.15
chr14_50507439_50508114	0.17	ENSG00000201358	.	27510	0.13
chr22_40349969_40350170	0.17	RP3-370M22.8		6332	0.18
chr10_27145692_27145938	0.17	ABI1	abl-interactor 1	3977	0.23
chr3_114051977_114052128	0.17	ENSG00000207770	.	16636	0.16
chr14_99688948_99689139	0.17	AL109767.1		40242	0.16
chr14_35884998_35885149	0.17	NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	11121	0.26
chr14_98677293_98677464	0.17	ENSG00000222066	.	120709	0.06
chr2_231517982_231518133	0.17	CAB39	calcium binding protein 39	59503	0.11
chr5_87436602_87437127	0.17	TMEM161B	transmembrane protein 161B	79584	0.11
chr11_35180171_35180536	0.17	CD44	CD44 molecule (Indian blood group)	17765	0.15
chr3_133210635_133210930	0.17	BFSP2-AS1	BFSP2 antisense RNA 1	36162	0.16
chr2_193045009_193045160	0.17	TMEFF2	transmembrane protein with EGF-like and two follistatin-like domains 2	14166	0.3
chr17_26206098_26206388	0.17	LYRM9	LYR motif containing 9	4080	0.19
chr18_20629843_20630057	0.17	ENSG00000223023	.	25391	0.15
chr1_198509908_198510168	0.17	ATP6V1G3	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	37	0.99
chr5_43397749_43397909	0.17	CCL28	chemokine (C-C motif) ligand 28	463	0.84
chr17_16322494_16322752	0.17	TRPV2	transient receptor potential cation channel, subfamily V, member 2	28	0.96
chr8_59974482_59974633	0.17	RP11-25K19.1		57042	0.12
chr2_218811497_218811648	0.17	TNS1	tensin 1	2721	0.31
chr20_50019481_50019826	0.17	ENSG00000263645	.	25795	0.22
chr12_31231062_31231213	0.17	DDX11	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	317	0.82
chr7_149565914_149566574	0.17	ATP6V0E2	ATPase, H+ transporting V0 subunit e2	3813	0.19
chr1_246984990_246985280	0.17	ENSG00000252011	.	11696	0.16
chr6_37672753_37673067	0.17	MDGA1	MAM domain containing glycosylphosphatidylinositol anchor 1	5828	0.28
chr3_4881435_4881664	0.17	ENSG00000239126	.	38837	0.16
chrX_117644722_117644873	0.17	DOCK11	dedicator of cytokinesis 11	14925	0.24
chr11_32444065_32444216	0.17	WT1	Wilms tumor 1	4997	0.26
chr2_74518143_74518523	0.17	SLC4A5	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	501	0.75
chr3_188041188_188041339	0.17	LPP	LIM domain containing preferred translocation partner in lipoma	83611	0.1
chr12_12116177_12116328	0.17	ETV6	ets variant 6	77381	0.1
chr7_156744058_156744240	0.17	NOM1	nucleolar protein with MIF4G domain 1	1732	0.36
chr13_25200724_25201013	0.17	ENSG00000211508	.	17651	0.18
chr22_40915359_40915510	0.17	RP4-591N18.2		2370	0.26
chr11_11158749_11159001	0.17	RP11-567I13.1		215098	0.02
chr1_160605831_160606299	0.17	SLAMF1	signaling lymphocytic activation molecule family member 1	10746	0.16
chr1_203285551_203285702	0.17	ENSG00000202300	.	2601	0.25
chr3_56831512_56831764	0.17	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	4339	0.33
chr12_47588304_47588625	0.17	ENSG00000263838	.	6869	0.23
chr11_14436549_14436842	0.17	RRAS2	related RAS viral (r-ras) oncogene homolog 2	50643	0.14
chr10_96163536_96163687	0.17	TBC1D12	TBC1 domain family, member 12	1350	0.49
chr20_55204811_55205013	0.17	TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	378	0.84
chr2_198066929_198067080	0.17	ANKRD44	ankyrin repeat domain 44	4242	0.23
chr2_46089761_46089912	0.17	PRKCE	protein kinase C, epsilon	138205	0.05
chr17_66251665_66252057	0.17	ARSG	arylsulfatase G	3462	0.19
chr5_35618942_35619093	0.16	SPEF2	sperm flagellar 2	917	0.65
chr20_23620821_23620972	0.16	CST3	cystatin C	1786	0.34
chr16_9010574_9010725	0.16	USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	19064	0.15
chr15_64916469_64916762	0.16	ENSG00000207223	.	28472	0.13
chrX_99880234_99880385	0.16	TSPAN6	tetraspanin 6	11494	0.18
chr8_105634588_105634739	0.16	RP11-127H5.1	Uncharacterized protein	31702	0.18
chr4_83135377_83135528	0.16	ENSG00000202485	.	39752	0.19
chr15_101135936_101136223	0.16	LINS	lines homolog (Drosophila)	1062	0.44
chr8_97175837_97176070	0.16	GDF6	growth differentiation factor 6	2933	0.31
chr16_56296813_56297090	0.16	ENSG00000265281	.	17519	0.16
chr17_46911451_46911733	0.16	CALCOCO2	calcium binding and coiled-coil domain 2	3002	0.17
chr19_35867894_35868045	0.16	GPR42	G protein-coupled receptor 42 (gene/pseudogene)	5777	0.11
chr20_36322114_36322265	0.16	CTNNBL1	catenin, beta like 1	219	0.96
chr8_8195680_8195853	0.16	SGK223	Tyrosine-protein kinase SgK223	43491	0.16
chr6_1895461_1895612	0.16	GMDS	GDP-mannose 4,6-dehydratase	280689	0.01
chr4_15796755_15796906	0.16	CD38	CD38 molecule	16929	0.23
chr5_55980507_55980731	0.16	AC022431.2	Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.	78560	0.09
chr9_101789506_101789792	0.16	TGFBR1	transforming growth factor, beta receptor 1	76671	0.09
chr1_22414609_22414772	0.16	CDC42-IT1	CDC42 intronic transcript 1 (non-protein coding)	29000	0.12
chr10_6087510_6087742	0.16	IL2RA	interleukin 2 receptor, alpha	16627	0.13
chr10_116261811_116262124	0.16	ABLIM1	actin binding LIM protein 1	14215	0.25
chr1_157102658_157102809	0.16	ETV3	ets variant 3	5426	0.24
chr3_68106098_68106274	0.16	FAM19A1	family with sequence similarity 19 (chemokine (C-C motif)-like), member A1	50813	0.19
chr1_197745376_197745655	0.16	DENND1B	DENN/MADD domain containing 1B	752	0.71
chr14_76063633_76063784	0.16	ENSG00000201096	.	6808	0.16
chr8_59961070_59961221	0.16	RP11-328K2.1		55648	0.13
chr9_100689273_100689424	0.16	C9orf156	chromosome 9 open reading frame 156	4496	0.17

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.2	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.2	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.1	0.2	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.2	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.3	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.2	GO:0045780	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0	0.1	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.0	0.3	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0002669	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.2	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.2	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.0	0.1	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0002227	innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385)
0.0	0.1	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0051712	positive regulation of killing of cells of other organism(GO:0051712)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.3	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.0	GO:0072224	metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.0	0.1	GO:0072133	kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0	0.1	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0072033	renal vesicle formation(GO:0072033)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0002329	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0002691	regulation of cellular extravasation(GO:0002691)
0.0	0.1	GO:0007501	mesodermal cell fate specification(GO:0007501)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0043379	T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) memory T cell differentiation(GO:0043379) regulation of memory T cell differentiation(GO:0043380) positive regulation of memory T cell differentiation(GO:0043382) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540) regulation of T-helper 17 type immune response(GO:2000316) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 17 cell differentiation(GO:2000319) positive regulation of T-helper 17 cell differentiation(GO:2000321) regulation of T-helper 17 cell lineage commitment(GO:2000328) positive regulation of T-helper 17 cell lineage commitment(GO:2000330)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.1	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.1	GO:0003351	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.1	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.2	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.0	0.1	GO:0001553	luteinization(GO:0001553)
0.0	0.1	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	1.1	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.1	GO:0045070	positive regulation of viral genome replication(GO:0045070)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.2	GO:0000085	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.0	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.1	GO:0042104	positive regulation of activated T cell proliferation(GO:0042104)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.0	GO:0033622	integrin activation(GO:0033622)
0.0	0.2	GO:0016180	snRNA processing(GO:0016180)
0.0	0.1	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.0	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.0	GO:0070857	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0	0.0	GO:0035082	axoneme assembly(GO:0035082)
0.0	0.0	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) membrane raft localization(GO:0051665)
0.0	0.0	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.0	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0	0.0	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.1	GO:0060088	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.0	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0051322	anaphase(GO:0051322)
0.0	0.0	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.0	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.1	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.0	GO:0071803	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.0	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.1	GO:0045040	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.0	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:1903170	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.0	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.0	GO:0010866	regulation of triglyceride biosynthetic process(GO:0010866)
0.0	0.1	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.0	0.1	GO:0051294	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.1	GO:0009086	methionine biosynthetic process(GO:0009086)
0.0	0.0	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:1903313	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.0	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.1	GO:0050710	negative regulation of cytokine secretion(GO:0050710)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.1	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.0	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.0	GO:0070602	centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0	0.1	GO:0008105	asymmetric protein localization(GO:0008105)
0.0	0.0	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0060292	long term synaptic depression(GO:0060292)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.0	GO:0033088	negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.0	GO:0048478	replication fork protection(GO:0048478)
0.0	0.0	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.0	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.0	GO:0043276	anoikis(GO:0043276)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.0	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.1	GO:0006590	thyroid hormone generation(GO:0006590)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.0	GO:0032971	regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.0	0.0	GO:0042670	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0	0.0	GO:0051023	immunoglobulin secretion(GO:0048305) regulation of immunoglobulin secretion(GO:0051023)
0.0	0.0	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.0	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.0	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.1	GO:0006787	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.0	GO:0045842	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0	0.2	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.0	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.0	GO:0031440	regulation of mRNA 3'-end processing(GO:0031440)
0.0	0.1	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.0	0.0	GO:0060363	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.2	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.2	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.2	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.2	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.1	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.0	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.0	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0005838	proteasome regulatory particle(GO:0005838)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.2	GO:0032039	integrator complex(GO:0032039)
0.0	0.0	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.1	GO:0090576	RNA polymerase III transcription factor complex(GO:0090576)
0.0	0.0	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.0	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.0	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.0	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.0	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.0	GO:0042827	platelet dense granule(GO:0042827)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.0	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.3	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	0.0	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.2	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.3	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0003964	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0	0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.3	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.2	GO:0016274	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0004583	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.0	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.1	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.0	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.0	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.2	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.0	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.0	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.0	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.0	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.0	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.2	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.0	GO:0051734	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0090079	translation activator activity(GO:0008494) translation regulator activity, nucleic acid binding(GO:0090079)
0.0	0.2	GO:0019534	toxin transporter activity(GO:0019534)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.0	GO:0015307	drug:proton antiporter activity(GO:0015307)
0.0	0.1	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.0	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.1	GO:0030547	receptor inhibitor activity(GO:0030547)
0.0	0.1	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.0	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.1	GO:0009922	fatty acid elongase activity(GO:0009922)
0.0	0.1	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0035004	phosphatidylinositol 3-kinase activity(GO:0035004)
0.0	0.0	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.0	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.1	GO:0004559	alpha-mannosidase activity(GO:0004559)
0.0	0.0	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
1.7	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.7	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.1	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.1	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.2	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.5	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.2	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.2	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.2	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.7	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.3	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.5	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.3	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.3	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	Genes involved in Signaling by the B Cell Receptor (BCR)
0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.2	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.3	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.2	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.2	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.2	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.2	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.2	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	REACTOME CA DEPENDENT EVENTS	Genes involved in Ca-dependent events