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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for STAT5B

Z-value: 1.14

Motif logo

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Transcription factors associated with STAT5B

Gene Symbol Gene ID Gene Info
STAT5B
ENSG00000173757.5 signal transducer and activator of transcription 5B

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr17_40432256_40432407STAT5B36060.1417220.383.1e-01Click!
chr17_40429586_40429737STAT5B9360.420722-0.343.7e-01Click!
chr17_40426499_40426859STAT5B17450.2095250.176.6e-01Click!
chr17_40429343_40429519STAT5B7060.537412-0.166.8e-01Click!
chr17_40428842_40429255STAT5B3230.813863-0.156.9e-01Click!

Activity of the STAT5B motif across conditions

Conditions sorted by the z-value of the STAT5B motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr18_47312188_47312542 0.48 ACAA2
 acetyl-CoA acyltransferase 2
 25536
 0.13
chrY_7107911_7108062 0.43 PRKY
 protein kinase, Y-linked, pseudogene
 34350
 0.2
chr1_90077786_90078098 0.42 RP11-413E1.4
17342
 0.16
chr15_38976681_38977159 0.40 C15orf53
 chromosome 15 open reading frame 53
 11879
 0.28
chr22_20905976_20906459 0.38 MED15
 mediator complex subunit 15
 640
 0.64
chr1_100917512_100917831 0.38 RP5-837M10.4
33882
 0.17
chr2_158752002_158752244 0.36 ENSG00000251980
 .
 17161
 0.16
chr21_34934879_34935141 0.36 SON
 SON DNA binding protein
 7655
 0.13
chr2_204596118_204596345 0.35 CD28
 CD28 molecule
 24815
 0.19
chr1_117307462_117307691 0.34 CD2
 CD2 molecule
 10487
 0.22
chr5_133470070_133470307 0.34 TCF7
 transcription factor 7 (T-cell specific, HMG-box)
 7688
 0.21
chr3_183894047_183894471 0.34 AP2M1
 adaptor-related protein complex 2, mu 1 subunit
 307
 0.81
chr13_40794695_40794922 0.34 ENSG00000207458
 .
 6156
 0.33
chr10_17469337_17469935 0.34 ST8SIA6-AS1
 ST8SIA6 antisense RNA 1
 19610
 0.17
chr10_22029411_22029562 0.33 ENSG00000252634
 .
 44735
 0.15
chr3_18754666_18754966 0.33 ENSG00000228956
 .
 19437
 0.29
chr14_64979460_64979611 0.32 ZBTB25
 zinc finger and BTB domain containing 25
 7604
 0.12
chr1_116931483_116931823 0.32 AL136376.1
 Uncharacterized protein
 4935
 0.17
chr11_128493152_128493455 0.32 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 35850
 0.16
chr7_86841162_86841366 0.32 ENSG00000200397
 .
 6764
 0.19
chr6_159434242_159434587 0.31 RP1-111C20.4
12564
 0.17
chr4_109015585_109015736 0.31 LEF1
 lymphoid enhancer-binding factor 1
 71797
 0.1
chr13_30718779_30718992 0.31 ENSG00000266816
 .
 61951
 0.14
chr5_176859524_176860060 0.31 GRK6
 G protein-coupled receptor kinase 6
 5937
 0.1
chr15_81587451_81588017 0.31 IL16
 interleukin 16
 1520
 0.42
chr1_172677197_172677413 0.31 FASLG
 Fas ligand (TNF superfamily, member 6)
 49147
 0.17
chr20_39791552_39791703 0.30 RP1-1J6.2
24984
 0.17
chr11_121356356_121356507 0.30 RP11-730K11.1
32709
 0.2
chr5_527779_527941 0.29 RP11-310P5.2
3040
 0.17
chr1_205774264_205775306 0.29 SLC41A1
 solute carrier family 41 (magnesium transporter), member 1
 7519
 0.17
chr1_101394971_101395556 0.29 SLC30A7
 solute carrier family 30 (zinc transporter), member 7
 32121
 0.12
chr6_112098947_112099288 0.29 FYN
 FYN oncogene related to SRC, FGR, YES
 3166
 0.35
chr9_139298088_139298507 0.29 SDCCAG3
 serologically defined colon cancer antigen 3
 3340
 0.13
chr22_42569550_42569701 0.28 RP4-669P10.16
33687
 0.1
chr1_25318169_25318460 0.28 RUNX3
 runt-related transcription factor 3
 26813
 0.16
chr7_138781462_138781646 0.28 ZC3HAV1
 zinc finger CCCH-type, antiviral 1
 12546
 0.2
chr10_106067575_106067726 0.28 RP11-127L20.5
4249
 0.15
chr4_108957054_108957236 0.28 HADH
 hydroxyacyl-CoA dehydrogenase
 31354
 0.18
chr14_64332649_64332871 0.28 SYNE2
 spectrin repeat containing, nuclear envelope 2
 13028
 0.21
chr6_112035608_112035759 0.27 FYN
 FYN oncogene related to SRC, FGR, YES
 5582
 0.27
chr1_100876837_100877178 0.27 ENSG00000216067
 .
 32676
 0.16
chr13_42967027_42967422 0.27 AKAP11
 A kinase (PRKA) anchor protein 11
 120935
 0.06
chr3_97687388_97687539 0.27 MINA
 MYC induced nuclear antigen
 3258
 0.29
chr5_156621341_156621645 0.27 ITK
 IL2-inducible T-cell kinase
 13656
 0.12
chr17_64281240_64281609 0.27 PRKCA
 protein kinase C, alpha
 17520
 0.17
chr2_42525652_42525803 0.27 EML4
 echinoderm microtubule associated protein like 4
 2666
 0.35
chr15_44974770_44974921 0.26 PATL2
 protein associated with topoisomerase II homolog 2 (yeast)
 5759
 0.15
chr14_103249636_103249863 0.26 TRAF3
 TNF receptor-associated factor 3
 5794
 0.19
chr11_128180292_128180443 0.26 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 194922
 0.03
chr14_81658914_81659190 0.26 ENSG00000221303
 .
 10126
 0.2
chr14_106453805_106454306 0.26 IGHV1-2
 immunoglobulin heavy variable 1-2
 885
 0.24
chrX_109480825_109481085 0.26 ENSG00000208883
 .
 12664
 0.23
chr14_98899836_98899987 0.26 ENSG00000241757
 .
 81910
 0.11
chr15_89192402_89192720 0.26 ISG20
 interferon stimulated exonuclease gene 20kDa
 10377
 0.17
chr16_16053619_16053929 0.25 ABCC1
 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
 10340
 0.22
chr6_154563218_154563545 0.25 IPCEF1
 interaction protein for cytohesin exchange factors 1
 4609
 0.35
chrY_7170357_7170537 0.25 ENSG00000252633
 .
 22189
 0.18
chr5_68856437_68856599 0.25 GTF2H2C
 general transcription factor IIH, polypeptide 2C
 397
 0.81
chr6_112076190_112076589 0.25 FYN
 FYN oncogene related to SRC, FGR, YES
 3928
 0.32
chr12_50980228_50980379 0.25 ENSG00000207136
 .
 46753
 0.13
chr5_169700644_169700966 0.25 LCP2
 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
 6474
 0.24
chrX_19814457_19814733 0.25 SH3KBP1
 SH3-domain kinase binding protein 1
 3274
 0.37
chr2_12643487_12643790 0.25 ENSG00000207183
 .
 92011
 0.09
chr15_62148914_62149135 0.25 RP11-16B9.1
22073
 0.23
chr13_99152294_99152445 0.25 STK24
 serine/threonine kinase 24
 19152
 0.2
chr1_93369105_93369256 0.24 ENSG00000207022
 .
 57564
 0.07
chr6_152491729_152491880 0.24 SYNE1
 spectrin repeat containing, nuclear envelope 1
 2305
 0.44
chr2_86332208_86332925 0.24 POLR1A
 polymerase (RNA) I polypeptide A, 194kDa
 712
 0.41
chr2_148616819_148616970 0.24 ACVR2A
 activin A receptor, type IIA
 14709
 0.19
chr7_134333204_134333355 0.24 BPGM
 2,3-bisphosphoglycerate mutase
 1696
 0.47
chr11_73716797_73717380 0.24 UCP3
 uncoupling protein 3 (mitochondrial, proton carrier)
 1261
 0.4
chr4_153020620_153020907 0.24 ENSG00000253077
 .
 127998
 0.05
chr17_64282506_64282856 0.24 PRKCA
 protein kinase C, alpha
 16263
 0.17
chr6_7232700_7232875 0.24 RP11-69L16.4
43477
 0.12
chr4_123537684_123537835 0.24 IL21-AS1
 IL21 antisense RNA 1
 2379
 0.32
chr2_97008256_97008637 0.24 NCAPH
 non-SMC condensin I complex, subunit H
 6890
 0.15
chr4_109053448_109053638 0.24 LEF1
 lymphoid enhancer-binding factor 1
 33914
 0.18
chr2_85072509_85072697 0.24 TRABD2A
 TraB domain containing 2A
 35603
 0.16
chr2_30478275_30478623 0.24 LBH
 limb bud and heart development
 23403
 0.22
chr11_34087322_34087473 0.24 CAPRIN1
 cell cycle associated protein 1
 12869
 0.23
chr13_20539466_20539748 0.24 ZMYM2
 zinc finger, MYM-type 2
 6684
 0.22
chr6_158779170_158779472 0.24 RP11-732M18.2
40272
 0.15
chr18_9125674_9125825 0.24 RP11-143J12.2
7671
 0.16
chr14_98163687_98163838 0.23 RP11-204N11.1
 Uncharacterized protein
 65406
 0.15
chr17_14018512_14018663 0.23 COX10
 cytochrome c oxidase assembly homolog 10 (yeast)
 45666
 0.14
chr19_30437152_30437303 0.23 URI1
 URI1, prefoldin-like chaperone
 3802
 0.36
chr4_143618071_143618255 0.23 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 136341
 0.05
chr2_148420447_148420598 0.23 ENSG00000253083
 .
 50601
 0.16
chr11_36615933_36616230 0.23 C11orf74
 chromosome 11 open reading frame 74
 14
 0.75
chr6_37009553_37009713 0.23 COX6A1P2
 cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
 2974
 0.26
chr3_125745459_125745610 0.23 SLC41A3
 solute carrier family 41, member 3
 30147
 0.12
chr15_64918455_64918632 0.23 ENSG00000207223
 .
 26544
 0.13
chr15_61137584_61137751 0.23 RP11-554D20.1
80728
 0.1
chr11_1526857_1527008 0.23 MOB2
 MOB kinase activator 2
 18956
 0.14
chr8_109256633_109256784 0.23 EIF3E
 eukaryotic translation initiation factor 3, subunit E
 4189
 0.29
chr3_105553902_105554145 0.23 CBLB
 Cbl proto-oncogene B, E3 ubiquitin protein ligase
 33864
 0.25
chr6_87874820_87875077 0.23 ZNF292
 zinc finger protein 292
 9609
 0.2
chr1_101775753_101776036 0.23 RP4-575N6.5
67180
 0.1
chr2_136806710_136807017 0.23 AC093391.2
36828
 0.17
chr4_178322553_178322704 0.23 AGA
 aspartylglucosaminidase
 38150
 0.13
chr2_204594628_204594779 0.23 CD28
 CD28 molecule
 23287
 0.19
chr15_38950800_38950951 0.23 C15orf53
 chromosome 15 open reading frame 53
 37924
 0.19
chr9_98444198_98444349 0.23 DKFZP434H0512
 Protein LOC100506667; Putative uncharacterized protein DKFZp434H0512
 90332
 0.08
chr7_50436926_50437104 0.23 ENSG00000200815
 .
 66063
 0.11
chr13_100003784_100004063 0.23 ENSG00000207719
 .
 4462
 0.24
chr14_70240039_70240190 0.23 SRSF5
 serine/arginine-rich splicing factor 5
 5457
 0.22
chr2_203517404_203517555 0.23 FAM117B
 family with sequence similarity 117, member B
 17568
 0.27
chr20_1651387_1651538 0.23 ENSG00000242348
 .
 4456
 0.18
chrX_135681382_135681565 0.23 ENSG00000252320
 .
 16074
 0.14
chr16_84692201_84692352 0.22 KLHL36
 kelch-like family member 36
 9704
 0.19
chr3_107800630_107800895 0.22 CD47
 CD47 molecule
 9099
 0.31
chr13_114867198_114867474 0.22 RASA3-IT1
 RASA3 intronic transcript 1 (non-protein coding)
 6959
 0.24
chr4_26869391_26869781 0.22 STIM2
 stromal interaction molecule 2
 6505
 0.25
chr13_49512520_49512861 0.22 ENSG00000265585
 .
 8342
 0.23
chr2_106502166_106502351 0.22 AC009505.2
28625
 0.21
chr11_128186968_128187150 0.22 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 188230
 0.03
chr3_38038605_38038970 0.22 VILL
 villin-like
 3143
 0.18
chr10_3843359_3843510 0.22 KLF6
 Kruppel-like factor 6
 15961
 0.22
chr11_118465900_118466051 0.22 ENSG00000207185
 .
 1272
 0.31
chr7_27794809_27794960 0.22 AC004549.6
14870
 0.21
chr11_6759714_6760047 0.22 GVINP1
 GTPase, very large interferon inducible pseudogene 1
 16769
 0.12
chr21_45440771_45440922 0.22 TRAPPC10
 trafficking protein particle complex 10
 8646
 0.18
chr2_46532306_46532656 0.22 EPAS1
 endothelial PAS domain protein 1
 7940
 0.28
chr1_204514309_204514562 0.22 MDM4
 Mdm4 p53 binding protein homolog (mouse)
 2518
 0.25
chr12_67713687_67713838 0.22 CAND1
 cullin-associated and neddylation-dissociated 1
 21010
 0.29
chr5_110608651_110608802 0.22 AC010468.2
2939
 0.29
chr9_114764702_114764964 0.22 ENSG00000222356
 .
 5814
 0.22
chr10_94997945_94998096 0.22 CYP26A1
 cytochrome P450, family 26, subfamily A, polypeptide 1
 164373
 0.03
chr1_169660668_169660923 0.22 SELL
 selectin L
 20044
 0.18
chr17_63739557_63739708 0.22 CEP112
 centrosomal protein 112kDa
 7210
 0.33
chr2_143890646_143890911 0.22 ARHGAP15
 Rho GTPase activating protein 15
 3895
 0.31
chr12_94426058_94426224 0.22 ENSG00000223126
 .
 23318
 0.22
chrX_13016516_13016803 0.21 TMSB4X
 thymosin beta 4, X-linked
 22882
 0.2
chr8_29275044_29275195 0.21 RP4-676L2.1
64432
 0.1
chr2_26033142_26033293 0.21 ASXL2
 additional sex combs like 2 (Drosophila)
 30039
 0.2
chr17_37914078_37914229 0.21 GRB7
 growth factor receptor-bound protein 7
 15648
 0.11
chr5_156620201_156620352 0.21 ITK
 IL2-inducible T-cell kinase
 12439
 0.13
chr11_6459562_6459838 0.21 HPX
 hemopexin
 2594
 0.18
chr13_43562200_43562351 0.21 EPSTI1
 epithelial stromal interaction 1 (breast)
 3092
 0.34
chr17_47814021_47814341 0.21 FAM117A
 family with sequence similarity 117, member A
 12292
 0.14
chr3_50609823_50610526 0.21 C3orf18
 chromosome 3 open reading frame 18
 1752
 0.28
chr12_3857476_3857740 0.21 EFCAB4B
 EF-hand calcium binding domain 4B
 4655
 0.27
chr9_36396152_36396303 0.21 RNF38
 ring finger protein 38
 3986
 0.31
chr18_13377226_13377600 0.21 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
 5140
 0.18
chr17_19671636_19671875 0.21 ALDH3A1
 aldehyde dehydrogenase 3 family, member A1
 19499
 0.14
chr18_13278050_13278201 0.21 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
 23
 0.98
chr1_65378377_65378528 0.21 JAK1
 Janus kinase 1
 53735
 0.15
chr7_17182799_17182976 0.21 AC003075.4
138040
 0.05
chr6_87876496_87876647 0.21 ZNF292
 zinc finger protein 292
 11232
 0.19
chr11_35180171_35180536 0.21 CD44
 CD44 molecule (Indian blood group)
 17765
 0.15
chr8_8757053_8757204 0.21 ENSG00000200713
 .
 3805
 0.23
chr6_24874747_24874898 0.21 FAM65B
 family with sequence similarity 65, member B
 2719
 0.29
chr2_225917234_225917562 0.21 DOCK10
 dedicator of cytokinesis 10
 10239
 0.28
chr13_107186047_107186257 0.21 EFNB2
 ephrin-B2
 1310
 0.56
chr8_118531704_118531855 0.21 MED30
 mediator complex subunit 30
 1173
 0.66
chr8_71130882_71131033 0.21 NCOA2
 nuclear receptor coactivator 2
 26653
 0.23
chr6_91182223_91182574 0.21 ENSG00000252676
 .
 25907
 0.24
chr14_92465964_92466115 0.21 TRIP11
 thyroid hormone receptor interactor 11
 16056
 0.18
chr1_116864629_116864780 0.21 ENSG00000221040
 .
 43476
 0.13
chr7_5872511_5872662 0.21 ZNF815P
 zinc finger protein 815, pseudogene
 9748
 0.16
chr9_101789506_101789792 0.21 TGFBR1
 transforming growth factor, beta receptor 1
 76671
 0.09
chr2_237449987_237450138 0.21 ACKR3
 atypical chemokine receptor 3
 26368
 0.2
chr3_128519253_128519404 0.21 RAB7A
 RAB7A, member RAS oncogene family
 5126
 0.2
chr11_60788871_60789172 0.21 CD6
 CD6 molecule
 13015
 0.14
chr17_27257426_27257577 0.21 PHF12
 PHD finger protein 12
 2193
 0.14
chr12_53024874_53025168 0.20 KRT73
 keratin 73
 12678
 0.1
chr3_31504876_31505139 0.20 ENSG00000238727
 .
 67578
 0.12
chr3_56769543_56769694 0.20 ARHGEF3
 Rho guanine nucleotide exchange factor (GEF) 3
 39977
 0.18
chr7_104685031_104685284 0.20 KMT2E
 lysine (K)-specific methyltransferase 2E
 30249
 0.14
chr1_8241900_8242051 0.20 ENSG00000200975
 .
 24682
 0.2
chr12_15715155_15715553 0.20 PTPRO
 protein tyrosine phosphatase, receptor type, O
 16068
 0.26
chr9_37187662_37187813 0.20 ENSG00000200502
 .
 27603
 0.18
chr8_141641731_141641895 0.20 AGO2
 argonaute RISC catalytic component 2
 3832
 0.28
chr8_20351774_20351998 0.20 ENSG00000251944
 .
 120551
 0.06
chr5_133437343_133437771 0.20 TCF7
 transcription factor 7 (T-cell specific, HMG-box)
 12845
 0.22
chr7_37403219_37403780 0.20 ELMO1
 engulfment and cell motility 1
 10227
 0.2
chr20_37491189_37491977 0.20 ENSG00000240474
 .
 9830
 0.2
chr2_87551962_87552113 0.20 IGKV3OR2-268
 immunoglobulin kappa variable 3/OR2-268 (non-functional)
 13597
 0.29
chr2_234324021_234324227 0.20 DGKD
 diacylglycerol kinase, delta 130kDa
 27324
 0.15
chr5_80400951_80401102 0.20 CTD-2193P3.2
9645
 0.28
chr4_114605766_114605917 0.20 CAMK2D
 calcium/calmodulin-dependent protein kinase II delta
 76383
 0.12
chr7_127029056_127029222 0.20 ZNF800
 zinc finger protein 800
 3033
 0.32
chr10_7534715_7534876 0.20 ENSG00000207453
 .
 6024
 0.26
chr1_192542393_192542550 0.20 RGS1
 regulator of G-protein signaling 1
 2386
 0.31
chr10_22889477_22889742 0.20 PIP4K2A
 phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
 8967
 0.3
chr19_47437080_47437279 0.20 ENSG00000252071
 .
 14367
 0.16
chr1_235467150_235467301 0.20 GGPS1
 geranylgeranyl diphosphate synthase 1
 23440
 0.17
chr12_58005832_58005987 0.20 ARHGEF25
 Rho guanine nucleotide exchange factor (GEF) 25
 691
 0.44
chr10_133791283_133791434 0.19 BNIP3
 BCL2/adenovirus E1B 19kDa interacting protein 3
 4069
 0.29
chr10_116303453_116303879 0.19 ABLIM1
 actin binding LIM protein 1
 16976
 0.26
chr22_35710419_35710852 0.19 TOM1
 target of myb1 (chicken)
 3580
 0.2
chr16_11650633_11650907 0.19 LITAF
 lipopolysaccharide-induced TNF factor
 29459
 0.14
chr7_106818278_106818489 0.19 HBP1
 HMG-box transcription factor 1
 1688
 0.39
chr13_99209848_99210037 0.19 STK24
 serine/threonine kinase 24
 19175
 0.2
chr11_9862251_9862402 0.19 SBF2
 SET binding factor 2
 1176
 0.37
chr1_193473917_193474216 0.19 ENSG00000252241
 .
 227008
 0.02
chr5_69711537_69711734 0.19 GTF2H2B
 general transcription factor IIH, polypeptide 2B (pseudogene)
 414
 0.9
chr1_85396278_85396429 0.19 LPAR3
 lysophosphatidic acid receptor 3
 37457
 0.16
chr5_172493244_172493458 0.19 CREBRF
 CREB3 regulatory factor
 8954
 0.16
chr1_148602023_148602174 0.19 ENSG00000207205
 .
 2974
 0.33

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT5B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.3 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1 0.2 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 0.1 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.1 0.1 GO:0044415 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.1 0.2 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1 0.2 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 0.4 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.1 0.2 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 0.2 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0060242 contact inhibition(GO:0060242)
0.0 0.1 GO:0046137 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0002911 lymphocyte anergy(GO:0002249) T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.2 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 1.1 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.2 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.1 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.1 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.1 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.2 GO:0070670 response to interleukin-4(GO:0070670)
0.0 0.1 GO:0002890 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0 0.2 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.2 GO:0045348 positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0 0.1 GO:0010715 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.1 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.1 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.2 GO:0035246 peptidyl-arginine N-methylation(GO:0035246)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.0 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.2 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.0 0.1 GO:0050687 negative regulation of defense response to virus(GO:0050687)
0.0 0.1 GO:0032656 regulation of interleukin-13 production(GO:0032656)
0.0 0.1 GO:0042508 tyrosine phosphorylation of Stat1 protein(GO:0042508)
0.0 0.1 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.1 GO:0045630 positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0 0.1 GO:0032119 sequestering of zinc ion(GO:0032119)
0.0 0.0 GO:1903312 negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0 0.1 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.0 GO:0032825 regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0 0.3 GO:0060324 face development(GO:0060324)
0.0 0.0 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.1 GO:0031297 replication fork processing(GO:0031297)
0.0 0.1 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.1 GO:0006678 glucosylceramide metabolic process(GO:0006678)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.0 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.1 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0002360 T cell lineage commitment(GO:0002360)
0.0 0.1 GO:0032925 regulation of activin receptor signaling pathway(GO:0032925)
0.0 0.1 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.1 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.1 GO:0009103 lipopolysaccharide biosynthetic process(GO:0009103)
0.0 0.1 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.1 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0 0.2 GO:0048821 erythrocyte development(GO:0048821) myeloid cell development(GO:0061515)
0.0 0.1 GO:0042713 sperm ejaculation(GO:0042713)
0.0 0.1 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0007063 regulation of sister chromatid cohesion(GO:0007063)
0.0 0.0 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.1 GO:0072283 mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003337) metanephric renal vesicle morphogenesis(GO:0072283)
0.0 0.1 GO:0032060 bleb assembly(GO:0032060)
0.0 0.1 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.1 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.1 GO:0042977 activation of JAK2 kinase activity(GO:0042977)
0.0 0.1 GO:0002335 mature B cell differentiation(GO:0002335)
0.0 0.2 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 1.2 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.0 GO:0016137 glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0 0.0 GO:0060426 lung vasculature development(GO:0060426)
0.0 0.1 GO:0043267 negative regulation of potassium ion transport(GO:0043267)
0.0 0.1 GO:0060206 estrous cycle phase(GO:0060206)
0.0 0.0 GO:0002125 maternal aggressive behavior(GO:0002125)
0.0 0.2 GO:0000303 response to superoxide(GO:0000303)
0.0 0.0 GO:0051665 membrane raft localization(GO:0051665)
0.0 0.0 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.0 GO:0001743 optic placode formation(GO:0001743)
0.0 0.1 GO:0061756 leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0 0.1 GO:0071168 protein localization to chromatin(GO:0071168)
0.0 0.0 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.0 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.2 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.0 GO:0046877 regulation of saliva secretion(GO:0046877)
0.0 0.0 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.1 GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0 0.0 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.1 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.0 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:0003351 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.0 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.0 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.0 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.2 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.1 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.0 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.1 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.0 GO:1904376 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.1 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.0 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.0 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0090114 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.0 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.0 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.1 GO:0048261 negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0 0.0 GO:0045628 regulation of T-helper 2 cell differentiation(GO:0045628)
0.0 0.0 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.0 GO:0002827 positive regulation of T-helper 1 type immune response(GO:0002827)
0.0 0.0 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0 0.1 GO:0060479 lung cell differentiation(GO:0060479)
0.0 0.1 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389) regulation of cell cycle G2/M phase transition(GO:1902749)
0.0 0.1 GO:0008634 obsolete negative regulation of survival gene product expression(GO:0008634)
0.0 0.2 GO:0098781 ncRNA transcription(GO:0098781)
0.0 0.0 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.1 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.0 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.0 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.0 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.0 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.0 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.1 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.0 GO:0071265 amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0 0.0 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.0 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.0 0.1 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.0 0.0 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.0 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.0 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002923)
0.0 0.0 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0 0.0 GO:0060023 soft palate development(GO:0060023)
0.0 0.0 GO:0033160 positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0 0.0 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.0 GO:2000188 regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.2 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.3 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 0.2 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.1 GO:0042627 chylomicron(GO:0042627)
0.0 0.0 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.2 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.0 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0071564 npBAF complex(GO:0071564)
0.0 0.0 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0001741 XY body(GO:0001741)
0.0 0.0 GO:0032009 early phagosome(GO:0032009)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.1 GO:0042555 MCM complex(GO:0042555)
0.0 0.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.2 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0035514 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.2 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.2 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0004083 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0060229 lipase activator activity(GO:0060229)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.1 GO:0015925 galactosidase activity(GO:0015925)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.5 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.1 GO:0016362 activin receptor activity, type II(GO:0016362)
0.0 0.0 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.2 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.1 GO:0032407 MutSalpha complex binding(GO:0032407)
0.0 0.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.1 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.0 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.1 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.0 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451)
0.0 0.0 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.0 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.0 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.0 GO:0032554 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.0 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.0 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.1 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.0 GO:0035197 siRNA binding(GO:0035197)
0.0 0.1 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.0 0.0 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.2 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.2 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.0 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.1 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.0 0.3 GO:0003823 antigen binding(GO:0003823)
0.0 0.0 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.0 GO:0005113 patched binding(GO:0005113)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.0 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.0 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.0 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 1.1 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.3 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.9 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 0.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.4 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.2 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.2 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.1 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.1 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.2 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.0 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.5 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.5 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.0 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.1 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.0 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.0 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 0.2 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 0.0 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.1 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.0 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.1 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.2 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.0 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0 0.0 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.1 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway