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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for STAT5B

Z-value: 1.14

Motif logo

Transcription factors associated with STAT5B

Gene Symbol	Gene ID	Gene Info
STAT5B Ensembl NCBI GeneCards UniProt	ENSG00000173757.5	STAT5B

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
STAT5B	chr17_40432256_40432407	3606	0.141722	0.38	3.1e-01	Click!
STAT5B	chr17_40429586_40429737	936	0.420722	-0.34	3.7e-01	Click!
STAT5B	chr17_40426499_40426859	1745	0.209525	0.17	6.6e-01	Click!
STAT5B	chr17_40429343_40429519	706	0.537412	-0.16	6.8e-01	Click!
STAT5B	chr17_40428842_40429255	323	0.813863	-0.15	6.9e-01	Click!

Activity of the STAT5B motif across conditions

Conditions sorted by the z-value of the STAT5B motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr18_47312188_47312542	0.48	ACAA2	acetyl-CoA acyltransferase 2	25536	0.13
chrY_7107911_7108062	0.43	PRKY	protein kinase, Y-linked, pseudogene	34350	0.2
chr1_90077786_90078098	0.42	RP11-413E1.4		17342	0.16
chr15_38976681_38977159	0.40	C15orf53	chromosome 15 open reading frame 53	11879	0.28
chr22_20905976_20906459	0.38	MED15	mediator complex subunit 15	640	0.64
chr1_100917512_100917831	0.38	RP5-837M10.4		33882	0.17
chr2_158752002_158752244	0.36	ENSG00000251980	.	17161	0.16
chr21_34934879_34935141	0.36	SON	SON DNA binding protein	7655	0.13
chr2_204596118_204596345	0.35	CD28	CD28 molecule	24815	0.19
chr1_117307462_117307691	0.34	CD2	CD2 molecule	10487	0.22
chr5_133470070_133470307	0.34	TCF7	transcription factor 7 (T-cell specific, HMG-box)	7688	0.21
chr3_183894047_183894471	0.34	AP2M1	adaptor-related protein complex 2, mu 1 subunit	307	0.81
chr13_40794695_40794922	0.34	ENSG00000207458	.	6156	0.33
chr10_17469337_17469935	0.34	ST8SIA6-AS1	ST8SIA6 antisense RNA 1	19610	0.17
chr10_22029411_22029562	0.33	ENSG00000252634	.	44735	0.15
chr3_18754666_18754966	0.33	ENSG00000228956	.	19437	0.29
chr14_64979460_64979611	0.32	ZBTB25	zinc finger and BTB domain containing 25	7604	0.12
chr1_116931483_116931823	0.32	AL136376.1	Uncharacterized protein	4935	0.17
chr11_128493152_128493455	0.32	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	35850	0.16
chr7_86841162_86841366	0.32	ENSG00000200397	.	6764	0.19
chr6_159434242_159434587	0.31	RP1-111C20.4		12564	0.17
chr4_109015585_109015736	0.31	LEF1	lymphoid enhancer-binding factor 1	71797	0.1
chr13_30718779_30718992	0.31	ENSG00000266816	.	61951	0.14
chr5_176859524_176860060	0.31	GRK6	G protein-coupled receptor kinase 6	5937	0.1
chr15_81587451_81588017	0.31	IL16	interleukin 16	1520	0.42
chr1_172677197_172677413	0.31	FASLG	Fas ligand (TNF superfamily, member 6)	49147	0.17
chr20_39791552_39791703	0.30	RP1-1J6.2		24984	0.17
chr11_121356356_121356507	0.30	RP11-730K11.1		32709	0.2
chr5_527779_527941	0.29	RP11-310P5.2		3040	0.17
chr1_205774264_205775306	0.29	SLC41A1	solute carrier family 41 (magnesium transporter), member 1	7519	0.17
chr1_101394971_101395556	0.29	SLC30A7	solute carrier family 30 (zinc transporter), member 7	32121	0.12
chr6_112098947_112099288	0.29	FYN	FYN oncogene related to SRC, FGR, YES	3166	0.35
chr9_139298088_139298507	0.29	SDCCAG3	serologically defined colon cancer antigen 3	3340	0.13
chr22_42569550_42569701	0.28	RP4-669P10.16		33687	0.1
chr1_25318169_25318460	0.28	RUNX3	runt-related transcription factor 3	26813	0.16
chr7_138781462_138781646	0.28	ZC3HAV1	zinc finger CCCH-type, antiviral 1	12546	0.2
chr10_106067575_106067726	0.28	RP11-127L20.5		4249	0.15
chr4_108957054_108957236	0.28	HADH	hydroxyacyl-CoA dehydrogenase	31354	0.18
chr14_64332649_64332871	0.28	SYNE2	spectrin repeat containing, nuclear envelope 2	13028	0.21
chr6_112035608_112035759	0.27	FYN	FYN oncogene related to SRC, FGR, YES	5582	0.27
chr1_100876837_100877178	0.27	ENSG00000216067	.	32676	0.16
chr13_42967027_42967422	0.27	AKAP11	A kinase (PRKA) anchor protein 11	120935	0.06
chr3_97687388_97687539	0.27	MINA	MYC induced nuclear antigen	3258	0.29
chr5_156621341_156621645	0.27	ITK	IL2-inducible T-cell kinase	13656	0.12
chr17_64281240_64281609	0.27	PRKCA	protein kinase C, alpha	17520	0.17
chr2_42525652_42525803	0.27	EML4	echinoderm microtubule associated protein like 4	2666	0.35
chr15_44974770_44974921	0.26	PATL2	protein associated with topoisomerase II homolog 2 (yeast)	5759	0.15
chr14_103249636_103249863	0.26	TRAF3	TNF receptor-associated factor 3	5794	0.19
chr11_128180292_128180443	0.26	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	194922	0.03
chr14_81658914_81659190	0.26	ENSG00000221303	.	10126	0.2
chr14_106453805_106454306	0.26	IGHV1-2	immunoglobulin heavy variable 1-2	885	0.24
chrX_109480825_109481085	0.26	ENSG00000208883	.	12664	0.23
chr14_98899836_98899987	0.26	ENSG00000241757	.	81910	0.11
chr15_89192402_89192720	0.26	ISG20	interferon stimulated exonuclease gene 20kDa	10377	0.17
chr16_16053619_16053929	0.25	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	10340	0.22
chr6_154563218_154563545	0.25	IPCEF1	interaction protein for cytohesin exchange factors 1	4609	0.35
chrY_7170357_7170537	0.25	ENSG00000252633	.	22189	0.18
chr5_68856437_68856599	0.25	GTF2H2C	general transcription factor IIH, polypeptide 2C	397	0.81
chr6_112076190_112076589	0.25	FYN	FYN oncogene related to SRC, FGR, YES	3928	0.32
chr12_50980228_50980379	0.25	ENSG00000207136	.	46753	0.13
chr5_169700644_169700966	0.25	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	6474	0.24
chrX_19814457_19814733	0.25	SH3KBP1	SH3-domain kinase binding protein 1	3274	0.37
chr2_12643487_12643790	0.25	ENSG00000207183	.	92011	0.09
chr15_62148914_62149135	0.25	RP11-16B9.1		22073	0.23
chr13_99152294_99152445	0.25	STK24	serine/threonine kinase 24	19152	0.2
chr1_93369105_93369256	0.24	ENSG00000207022	.	57564	0.07
chr6_152491729_152491880	0.24	SYNE1	spectrin repeat containing, nuclear envelope 1	2305	0.44
chr2_86332208_86332925	0.24	POLR1A	polymerase (RNA) I polypeptide A, 194kDa	712	0.41
chr2_148616819_148616970	0.24	ACVR2A	activin A receptor, type IIA	14709	0.19
chr7_134333204_134333355	0.24	BPGM	2,3-bisphosphoglycerate mutase	1696	0.47
chr11_73716797_73717380	0.24	UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	1261	0.4
chr4_153020620_153020907	0.24	ENSG00000253077	.	127998	0.05
chr17_64282506_64282856	0.24	PRKCA	protein kinase C, alpha	16263	0.17
chr6_7232700_7232875	0.24	RP11-69L16.4		43477	0.12
chr4_123537684_123537835	0.24	IL21-AS1	IL21 antisense RNA 1	2379	0.32
chr2_97008256_97008637	0.24	NCAPH	non-SMC condensin I complex, subunit H	6890	0.15
chr4_109053448_109053638	0.24	LEF1	lymphoid enhancer-binding factor 1	33914	0.18
chr2_85072509_85072697	0.24	TRABD2A	TraB domain containing 2A	35603	0.16
chr2_30478275_30478623	0.24	LBH	limb bud and heart development	23403	0.22
chr11_34087322_34087473	0.24	CAPRIN1	cell cycle associated protein 1	12869	0.23
chr13_20539466_20539748	0.24	ZMYM2	zinc finger, MYM-type 2	6684	0.22
chr6_158779170_158779472	0.24	RP11-732M18.2		40272	0.15
chr18_9125674_9125825	0.24	RP11-143J12.2		7671	0.16
chr14_98163687_98163838	0.23	RP11-204N11.1	Uncharacterized protein	65406	0.15
chr17_14018512_14018663	0.23	COX10	cytochrome c oxidase assembly homolog 10 (yeast)	45666	0.14
chr19_30437152_30437303	0.23	URI1	URI1, prefoldin-like chaperone	3802	0.36
chr4_143618071_143618255	0.23	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	136341	0.05
chr2_148420447_148420598	0.23	ENSG00000253083	.	50601	0.16
chr11_36615933_36616230	0.23	C11orf74	chromosome 11 open reading frame 74	14	0.75
chr6_37009553_37009713	0.23	COX6A1P2	cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2	2974	0.26
chr3_125745459_125745610	0.23	SLC41A3	solute carrier family 41, member 3	30147	0.12
chr15_64918455_64918632	0.23	ENSG00000207223	.	26544	0.13
chr15_61137584_61137751	0.23	RP11-554D20.1		80728	0.1
chr11_1526857_1527008	0.23	MOB2	MOB kinase activator 2	18956	0.14
chr8_109256633_109256784	0.23	EIF3E	eukaryotic translation initiation factor 3, subunit E	4189	0.29
chr3_105553902_105554145	0.23	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	33864	0.25
chr6_87874820_87875077	0.23	ZNF292	zinc finger protein 292	9609	0.2
chr1_101775753_101776036	0.23	RP4-575N6.5		67180	0.1
chr2_136806710_136807017	0.23	AC093391.2		36828	0.17
chr4_178322553_178322704	0.23	AGA	aspartylglucosaminidase	38150	0.13
chr2_204594628_204594779	0.23	CD28	CD28 molecule	23287	0.19
chr15_38950800_38950951	0.23	C15orf53	chromosome 15 open reading frame 53	37924	0.19
chr9_98444198_98444349	0.23	DKFZP434H0512	Protein LOC100506667; Putative uncharacterized protein DKFZp434H0512	90332	0.08
chr7_50436926_50437104	0.23	ENSG00000200815	.	66063	0.11
chr13_100003784_100004063	0.23	ENSG00000207719	.	4462	0.24
chr14_70240039_70240190	0.23	SRSF5	serine/arginine-rich splicing factor 5	5457	0.22
chr2_203517404_203517555	0.23	FAM117B	family with sequence similarity 117, member B	17568	0.27
chr20_1651387_1651538	0.23	ENSG00000242348	.	4456	0.18
chrX_135681382_135681565	0.23	ENSG00000252320	.	16074	0.14
chr16_84692201_84692352	0.22	KLHL36	kelch-like family member 36	9704	0.19
chr3_107800630_107800895	0.22	CD47	CD47 molecule	9099	0.31
chr13_114867198_114867474	0.22	RASA3-IT1	RASA3 intronic transcript 1 (non-protein coding)	6959	0.24
chr4_26869391_26869781	0.22	STIM2	stromal interaction molecule 2	6505	0.25
chr13_49512520_49512861	0.22	ENSG00000265585	.	8342	0.23
chr2_106502166_106502351	0.22	AC009505.2		28625	0.21
chr11_128186968_128187150	0.22	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	188230	0.03
chr3_38038605_38038970	0.22	VILL	villin-like	3143	0.18
chr10_3843359_3843510	0.22	KLF6	Kruppel-like factor 6	15961	0.22
chr11_118465900_118466051	0.22	ENSG00000207185	.	1272	0.31
chr7_27794809_27794960	0.22	AC004549.6		14870	0.21
chr11_6759714_6760047	0.22	GVINP1	GTPase, very large interferon inducible pseudogene 1	16769	0.12
chr21_45440771_45440922	0.22	TRAPPC10	trafficking protein particle complex 10	8646	0.18
chr2_46532306_46532656	0.22	EPAS1	endothelial PAS domain protein 1	7940	0.28
chr1_204514309_204514562	0.22	MDM4	Mdm4 p53 binding protein homolog (mouse)	2518	0.25
chr12_67713687_67713838	0.22	CAND1	cullin-associated and neddylation-dissociated 1	21010	0.29
chr5_110608651_110608802	0.22	AC010468.2		2939	0.29
chr9_114764702_114764964	0.22	ENSG00000222356	.	5814	0.22
chr10_94997945_94998096	0.22	CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	164373	0.03
chr1_169660668_169660923	0.22	SELL	selectin L	20044	0.18
chr17_63739557_63739708	0.22	CEP112	centrosomal protein 112kDa	7210	0.33
chr2_143890646_143890911	0.22	ARHGAP15	Rho GTPase activating protein 15	3895	0.31
chr12_94426058_94426224	0.22	ENSG00000223126	.	23318	0.22
chrX_13016516_13016803	0.21	TMSB4X	thymosin beta 4, X-linked	22882	0.2
chr8_29275044_29275195	0.21	RP4-676L2.1		64432	0.1
chr2_26033142_26033293	0.21	ASXL2	additional sex combs like 2 (Drosophila)	30039	0.2
chr17_37914078_37914229	0.21	GRB7	growth factor receptor-bound protein 7	15648	0.11
chr5_156620201_156620352	0.21	ITK	IL2-inducible T-cell kinase	12439	0.13
chr11_6459562_6459838	0.21	HPX	hemopexin	2594	0.18
chr13_43562200_43562351	0.21	EPSTI1	epithelial stromal interaction 1 (breast)	3092	0.34
chr17_47814021_47814341	0.21	FAM117A	family with sequence similarity 117, member A	12292	0.14
chr3_50609823_50610526	0.21	C3orf18	chromosome 3 open reading frame 18	1752	0.28
chr12_3857476_3857740	0.21	EFCAB4B	EF-hand calcium binding domain 4B	4655	0.27
chr9_36396152_36396303	0.21	RNF38	ring finger protein 38	3986	0.31
chr18_13377226_13377600	0.21	LDLRAD4	low density lipoprotein receptor class A domain containing 4	5140	0.18
chr17_19671636_19671875	0.21	ALDH3A1	aldehyde dehydrogenase 3 family, member A1	19499	0.14
chr18_13278050_13278201	0.21	LDLRAD4	low density lipoprotein receptor class A domain containing 4	23	0.98
chr1_65378377_65378528	0.21	JAK1	Janus kinase 1	53735	0.15
chr7_17182799_17182976	0.21	AC003075.4		138040	0.05
chr6_87876496_87876647	0.21	ZNF292	zinc finger protein 292	11232	0.19
chr11_35180171_35180536	0.21	CD44	CD44 molecule (Indian blood group)	17765	0.15
chr8_8757053_8757204	0.21	ENSG00000200713	.	3805	0.23
chr6_24874747_24874898	0.21	FAM65B	family with sequence similarity 65, member B	2719	0.29
chr2_225917234_225917562	0.21	DOCK10	dedicator of cytokinesis 10	10239	0.28
chr13_107186047_107186257	0.21	EFNB2	ephrin-B2	1310	0.56
chr8_118531704_118531855	0.21	MED30	mediator complex subunit 30	1173	0.66
chr8_71130882_71131033	0.21	NCOA2	nuclear receptor coactivator 2	26653	0.23
chr6_91182223_91182574	0.21	ENSG00000252676	.	25907	0.24
chr14_92465964_92466115	0.21	TRIP11	thyroid hormone receptor interactor 11	16056	0.18
chr1_116864629_116864780	0.21	ENSG00000221040	.	43476	0.13
chr7_5872511_5872662	0.21	ZNF815P	zinc finger protein 815, pseudogene	9748	0.16
chr9_101789506_101789792	0.21	TGFBR1	transforming growth factor, beta receptor 1	76671	0.09
chr2_237449987_237450138	0.21	ACKR3	atypical chemokine receptor 3	26368	0.2
chr3_128519253_128519404	0.21	RAB7A	RAB7A, member RAS oncogene family	5126	0.2
chr11_60788871_60789172	0.21	CD6	CD6 molecule	13015	0.14
chr17_27257426_27257577	0.21	PHF12	PHD finger protein 12	2193	0.14
chr12_53024874_53025168	0.20	KRT73	keratin 73	12678	0.1
chr3_31504876_31505139	0.20	ENSG00000238727	.	67578	0.12
chr3_56769543_56769694	0.20	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	39977	0.18
chr7_104685031_104685284	0.20	KMT2E	lysine (K)-specific methyltransferase 2E	30249	0.14
chr1_8241900_8242051	0.20	ENSG00000200975	.	24682	0.2
chr12_15715155_15715553	0.20	PTPRO	protein tyrosine phosphatase, receptor type, O	16068	0.26
chr9_37187662_37187813	0.20	ENSG00000200502	.	27603	0.18
chr8_141641731_141641895	0.20	AGO2	argonaute RISC catalytic component 2	3832	0.28
chr8_20351774_20351998	0.20	ENSG00000251944	.	120551	0.06
chr5_133437343_133437771	0.20	TCF7	transcription factor 7 (T-cell specific, HMG-box)	12845	0.22
chr7_37403219_37403780	0.20	ELMO1	engulfment and cell motility 1	10227	0.2
chr20_37491189_37491977	0.20	ENSG00000240474	.	9830	0.2
chr2_87551962_87552113	0.20	IGKV3OR2-268	immunoglobulin kappa variable 3/OR2-268 (non-functional)	13597	0.29
chr2_234324021_234324227	0.20	DGKD	diacylglycerol kinase, delta 130kDa	27324	0.15
chr5_80400951_80401102	0.20	CTD-2193P3.2		9645	0.28
chr4_114605766_114605917	0.20	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	76383	0.12
chr7_127029056_127029222	0.20	ZNF800	zinc finger protein 800	3033	0.32
chr10_7534715_7534876	0.20	ENSG00000207453	.	6024	0.26
chr1_192542393_192542550	0.20	RGS1	regulator of G-protein signaling 1	2386	0.31
chr10_22889477_22889742	0.20	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	8967	0.3
chr19_47437080_47437279	0.20	ENSG00000252071	.	14367	0.16
chr1_235467150_235467301	0.20	GGPS1	geranylgeranyl diphosphate synthase 1	23440	0.17
chr12_58005832_58005987	0.20	ARHGEF25	Rho guanine nucleotide exchange factor (GEF) 25	691	0.44
chr10_133791283_133791434	0.19	BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	4069	0.29
chr10_116303453_116303879	0.19	ABLIM1	actin binding LIM protein 1	16976	0.26
chr22_35710419_35710852	0.19	TOM1	target of myb1 (chicken)	3580	0.2
chr16_11650633_11650907	0.19	LITAF	lipopolysaccharide-induced TNF factor	29459	0.14
chr7_106818278_106818489	0.19	HBP1	HMG-box transcription factor 1	1688	0.39
chr13_99209848_99210037	0.19	STK24	serine/threonine kinase 24	19175	0.2
chr11_9862251_9862402	0.19	SBF2	SET binding factor 2	1176	0.37
chr1_193473917_193474216	0.19	ENSG00000252241	.	227008	0.02
chr5_69711537_69711734	0.19	GTF2H2B	general transcription factor IIH, polypeptide 2B (pseudogene)	414	0.9
chr1_85396278_85396429	0.19	LPAR3	lysophosphatidic acid receptor 3	37457	0.16
chr5_172493244_172493458	0.19	CREBRF	CREB3 regulatory factor	8954	0.16
chr1_148602023_148602174	0.19	ENSG00000207205	.	2974	0.33

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT5B

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.3	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.2	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.1	GO:0044415	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.2	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.2	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1	0.2	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.4	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.2	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.1	0.2	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0002911	lymphocyte anergy(GO:0002249) T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.2	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	1.1	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.2	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.2	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.2	GO:0045348	positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0	0.1	GO:0010715	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0034085	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.2	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0001514	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.2	GO:0002031	G-protein coupled receptor internalization(GO:0002031)
0.0	0.1	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.1	GO:0032656	regulation of interleukin-13 production(GO:0032656)
0.0	0.1	GO:0042508	tyrosine phosphorylation of Stat1 protein(GO:0042508)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.1	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.1	GO:0032119	sequestering of zinc ion(GO:0032119)
0.0	0.0	GO:1903312	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.1	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.0	0.2	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.2	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0032825	regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.3	GO:0060324	face development(GO:0060324)
0.0	0.0	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.1	GO:0031297	replication fork processing(GO:0031297)
0.0	0.1	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.1	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.1	GO:0006678	glucosylceramide metabolic process(GO:0006678)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.0	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0002360	T cell lineage commitment(GO:0002360)
0.0	0.1	GO:0032925	regulation of activin receptor signaling pathway(GO:0032925)
0.0	0.1	GO:0060017	parathyroid gland development(GO:0060017)
0.0	0.1	GO:0001675	acrosome assembly(GO:0001675)
0.0	0.1	GO:0009103	lipopolysaccharide biosynthetic process(GO:0009103)
0.0	0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.1	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0	0.2	GO:0048821	erythrocyte development(GO:0048821) myeloid cell development(GO:0061515)
0.0	0.1	GO:0042713	sperm ejaculation(GO:0042713)
0.0	0.1	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.1	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0	0.1	GO:0007063	regulation of sister chromatid cohesion(GO:0007063)
0.0	0.0	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.1	GO:0072283	mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003337) metanephric renal vesicle morphogenesis(GO:0072283)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.1	GO:0042977	activation of JAK2 kinase activity(GO:0042977)
0.0	0.1	GO:0002335	mature B cell differentiation(GO:0002335)
0.0	0.2	GO:0045947	negative regulation of translational initiation(GO:0045947)
0.0	1.2	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.0	GO:0016137	glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0	0.0	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0043267	negative regulation of potassium ion transport(GO:0043267)
0.0	0.1	GO:0060206	estrous cycle phase(GO:0060206)
0.0	0.0	GO:0002125	maternal aggressive behavior(GO:0002125)
0.0	0.2	GO:0000303	response to superoxide(GO:0000303)
0.0	0.0	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.0	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.0	GO:0001743	optic placode formation(GO:0001743)
0.0	0.1	GO:0061756	leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0	0.1	GO:0071168	protein localization to chromatin(GO:0071168)
0.0	0.0	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.0	GO:0051708	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.2	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.0	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.0	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.1	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.1	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.0	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.1	GO:0003351	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.0	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.0	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.2	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.1	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0030241	skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.1	GO:0048712	negative regulation of astrocyte differentiation(GO:0048712)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.0	GO:1904376	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.1	GO:0045646	regulation of erythrocyte differentiation(GO:0045646)
0.0	0.0	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0090114	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.0	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.2	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.0	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.1	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.0	GO:0045628	regulation of T-helper 2 cell differentiation(GO:0045628)
0.0	0.0	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.0	GO:0002827	positive regulation of T-helper 1 type immune response(GO:0002827)
0.0	0.0	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0	0.1	GO:0060479	lung cell differentiation(GO:0060479)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.1	GO:0010389	regulation of G2/M transition of mitotic cell cycle(GO:0010389) regulation of cell cycle G2/M phase transition(GO:1902749)
0.0	0.1	GO:0008634	obsolete negative regulation of survival gene product expression(GO:0008634)
0.0	0.2	GO:0098781	ncRNA transcription(GO:0098781)
0.0	0.0	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.1	GO:0035082	axoneme assembly(GO:0035082)
0.0	0.0	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.0	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.0	GO:0009822	alkaloid catabolic process(GO:0009822)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0	0.0	GO:0071265	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.1	GO:0051569	regulation of histone H3-K4 methylation(GO:0051569)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.0	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.0	GO:0002923	regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002923)
0.0	0.0	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0	0.0	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.0	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.0	GO:2000188	regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0048179	activin receptor complex(GO:0048179)
0.1	0.2	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.4	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.3	GO:0030132	clathrin coat of coated pit(GO:0030132)
0.0	0.2	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.1	GO:0042627	chylomicron(GO:0042627)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.2	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.4	GO:0016592	mediator complex(GO:0016592)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.0	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	0.1	GO:0071564	npBAF complex(GO:0071564)
0.0	0.0	GO:0070552	BRISC complex(GO:0070552)
0.0	0.1	GO:0001741	XY body(GO:0001741)
0.0	0.0	GO:0032009	early phagosome(GO:0032009)
0.0	0.2	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.1	GO:0042555	MCM complex(GO:0042555)
0.0	0.0	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.1	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.1	0.2	GO:0035184	histone threonine kinase activity(GO:0035184)
0.1	0.2	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.2	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.2	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.2	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0004083	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:0060229	lipase activator activity(GO:0060229)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.9	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.2	GO:0016273	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.3	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.3	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.5	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.1	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.0	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0032407	MutSalpha complex binding(GO:0032407)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0004583	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.0	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.1	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.1	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.0	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.2	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0005451	monovalent cation:proton antiporter activity(GO:0005451)
0.0	0.0	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.2	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.0	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.2	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.1	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.3	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.0	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.0	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0	0.3	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.0	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0036041	long-chain fatty acid binding(GO:0036041)
0.0	0.0	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.2	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.2	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0	0.2	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.0	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.1	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.1	GO:0003988	acetyl-CoA C-acyltransferase activity(GO:0003988)
0.0	0.3	GO:0003823	antigen binding(GO:0003823)
0.0	0.0	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.0	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.0	GO:0005113	patched binding(GO:0005113)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.0	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.0	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.0	GO:0030548	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	1.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.3	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.3	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.0	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	1.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.6	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.9	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	0.3	PID ARF 3PATHWAY	Arf1 pathway
0.0	0.3	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.4	PID ALK1 PATHWAY	ALK1 signaling events
0.0	0.5	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.2	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.2	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.1	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.0	0.1	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.0	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.4	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.2	PID MYC PATHWAY	C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.0	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.4	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.4	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.5	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.5	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.0	0.2	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.1	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	1.0	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.4	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.3	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.3	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.1	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.0	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.0	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0	0.2	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.0	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0	0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.0	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.0	0.3	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.1	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.2	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0	0.0	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.0	0.1	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.1	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway