CREMA results: TBX19

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Transcription factors associated with TBX19

Gene Symbol	Gene ID	Gene Info
TBX19 Ensembl NCBI GeneCards UniProt	ENSG00000143178.8	T-box transcription factor 19

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr1_168254552_168254703	TBX19	4349	0.233789	-0.00	1.0e+00	Click!
chr1_168271269_168271420	TBX19	4482	0.246188	-0.07	8.5e-01	Click!
chr1_168289944_168290095	TBX19	23157	0.190319	-0.27	4.8e-01	Click!
chr1_168290494_168290645	TBX19	23707	0.189074	-0.48	1.9e-01	Click!

Showing 1 to 4 of 4 entries

Activity of the TBX19 motif across conditions

Conditions sorted by the z-value of the TBX19 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_46530833_46530984	0.61	PGLYRP1	peptidoglycan recognition protein 1	4585	0.14
chr20_13838142_13838293	0.40	NDUFAF5	NADH dehydrogenase (ubiquinone) complex I, assembly factor 5	72521	0.1
chr5_141307102_141307397	0.30	KIAA0141	KIAA0141	3774	0.18
chr3_121386721_121386872	0.29	HCLS1	hematopoietic cell-specific Lyn substrate 1	7038	0.16
chr14_65165014_65165274	0.28	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	5676	0.24
chr15_70755158_70755354	0.28	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	239364	0.02
chr21_43614804_43615118	0.28	ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1	4838	0.21
chr10_82421596_82421747	0.27	SH2D4B	SH2 domain containing 4B	121096	0.06
chr2_198150239_198150434	0.26	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	16907	0.16
chr1_38958842_38958993	0.26	ENSG00000200796	.	96586	0.08

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX19

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0045576	mast cell activation(GO:0045576)
0.1	0.2	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.2	GO:0046398	UDP-glucuronate metabolic process(GO:0046398)
0.0	0.2	GO:0001878	response to yeast(GO:0001878)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.2	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.0	0.2	GO:0098927	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.2	GO:0061077	chaperone-mediated protein folding(GO:0061077)
0.0	0.2	GO:1900077	negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)

Showing 1 to 10 of 137 entries

Gene overrepresentation in cellular component category:

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Total log-likelihood	Term	Description
0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	GO:0070695	FHF complex(GO:0070695)
0.1	GO:0043218	compact myelin(GO:0043218)
0.1	GO:0030870	Mre11 complex(GO:0030870)
0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)

Showing 1 to 10 of 28 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0070492	oligosaccharide binding(GO:0070492)
0.1	0.2	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1	0.2	GO:0051425	PTB domain binding(GO:0051425)
0.1	0.2	GO:0043559	insulin binding(GO:0043559)
0.0	0.2	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.2	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.2	GO:0042171	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.2	GO:0046965	retinoid X receptor binding(GO:0046965)

Showing 1 to 10 of 111 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.7	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.5	PID IGF1 PATHWAY	IGF1 pathway
0.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4	PID EPO PATHWAY	EPO signaling pathway
0.3	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	PID IL5 PATHWAY	IL5-mediated signaling events

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.5	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.5	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.3	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.3	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.2	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets

Showing 1 to 10 of 21 entries

Results for TBX19

Z-value: 1.39

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Transcription factors associated with TBX19

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the TBX19 motif across conditions

Conditions sorted by the z-value of the TBX19 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX19

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: