Project

ENCODE: H3K4me1 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for TBX19

Z-value: 1.39

Motif logo

Transcription factors associated with TBX19

Gene Symbol	Gene ID	Gene Info
TBX19 Ensembl NCBI GeneCards UniProt	ENSG00000143178.8	TBX19

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
TBX19	chr1_168290494_168290645	23707	0.189074	-0.48	1.9e-01	Click!
TBX19	chr1_168289944_168290095	23157	0.190319	-0.27	4.8e-01	Click!
TBX19	chr1_168271269_168271420	4482	0.246188	-0.07	8.5e-01	Click!
TBX19	chr1_168254552_168254703	4349	0.233789	-0.00	1.0e+00	Click!

Activity of the TBX19 motif across conditions

Conditions sorted by the z-value of the TBX19 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_46530833_46530984	0.61	PGLYRP1	peptidoglycan recognition protein 1	4585	0.14
chr20_13838142_13838293	0.40	NDUFAF5	NADH dehydrogenase (ubiquinone) complex I, assembly factor 5	72521	0.1
chr5_141307102_141307397	0.30	KIAA0141	KIAA0141	3774	0.18
chr3_121386721_121386872	0.29	HCLS1	hematopoietic cell-specific Lyn substrate 1	7038	0.16
chr14_65165014_65165274	0.28	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	5676	0.24
chr15_70755158_70755354	0.28	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	239364	0.02
chr21_43614804_43615118	0.28	ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1	4838	0.21
chr10_82421596_82421747	0.27	SH2D4B	SH2 domain containing 4B	121096	0.06
chr2_198150239_198150434	0.26	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	16907	0.16
chr1_38958842_38958993	0.26	ENSG00000200796	.	96586	0.08
chr9_92272620_92272771	0.26	GADD45G	growth arrest and DNA-damage-inducible, gamma	52742	0.17
chr8_97662802_97662953	0.26	CPQ	carboxypeptidase Q	5274	0.31
chr17_40994693_40994844	0.25	AOC2	amine oxidase, copper containing 2 (retina-specific)	1849	0.16
chr14_91167266_91167417	0.25	RP11-661G16.2		3664	0.23
chr8_59068204_59068401	0.25	FAM110B	family with sequence similarity 110, member B	161189	0.04
chr14_90032899_90033050	0.25	FOXN3-AS2	FOXN3 antisense RNA 2	9586	0.17
chr2_118814167_118814318	0.25	INSIG2	insulin induced gene 2	31808	0.13
chr1_212000871_212001169	0.25	RP11-552D8.1		2168	0.25
chrX_134441517_134441668	0.25	ZNF75D	zinc finger protein 75D	11633	0.21
chr15_86078641_86078893	0.25	AKAP13	A kinase (PRKA) anchor protein 13	8504	0.21
chr20_31898220_31898371	0.25	BPIFB1	BPI fold containing family B, member 1	27354	0.14
chr17_74246966_74247117	0.24	RNF157	ring finger protein 157	10587	0.13
chr15_99488986_99489137	0.24	IGF1R	insulin-like growth factor 1 receptor	21232	0.19
chr16_15883480_15883631	0.24	AF001548.6		48547	0.1
chr18_74188097_74188669	0.24	ZNF516	zinc finger protein 516	14352	0.17
chr2_144450054_144450205	0.24	RP11-434H14.1		9621	0.23
chr4_184318912_184319063	0.24	ENSG00000263395	.	13281	0.17
chr20_58675900_58676156	0.24	C20orf197	chromosome 20 open reading frame 197	45048	0.18
chr1_52105044_52105195	0.24	OSBPL9	oxysterol binding protein-like 9	22338	0.19
chr18_43578628_43579079	0.23	ENSG00000222179	.	8942	0.2
chr1_32558443_32558736	0.23	ENSG00000266203	.	6039	0.13
chr21_15810558_15810709	0.23	HSPA13	heat shock protein 70kDa family, member 13	55125	0.15
chr8_10028580_10028731	0.23	MSRA	methionine sulfoxide reductase A	75418	0.1
chr3_196404146_196404677	0.23	ENSG00000201441	.	31424	0.1
chr3_131537149_131537300	0.23	CPNE4	copine IV	107201	0.07
chr2_202074857_202075031	0.23	CASP8	caspase 8, apoptosis-related cysteine peptidase	23222	0.14
chr1_180238065_180238216	0.23	RP5-1180C10.2		5676	0.25
chr12_110435362_110435658	0.23	GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	1316	0.37
chr20_24270958_24271313	0.23	ENSG00000200231	.	53244	0.17
chrX_65232472_65232880	0.22	ENSG00000207939	.	6036	0.22
chr6_5828955_5829300	0.22	ENSG00000239472	.	89950	0.09
chr14_91592357_91592508	0.22	ENSG00000221102	.	337	0.64
chr15_42662964_42663115	0.22	CAPN3	calpain 3, (p94)	11254	0.16
chr20_35586845_35586996	0.22	SAMHD1	SAM domain and HD domain 1	6674	0.24
chr18_74211925_74212216	0.22	RP11-17M16.1	uncharacterized protein LOC400658	4593	0.19
chr22_22304135_22304332	0.22	PPM1F	protein phosphatase, Mg2+/Mn2+ dependent, 1F	2970	0.16
chr14_64214575_64214726	0.22	ENSG00000252749	.	11488	0.18
chr11_78109102_78109366	0.22	RP11-452H21.2		10127	0.18
chr2_69063618_69063857	0.22	AC097495.2		1601	0.39
chr3_71376865_71377143	0.22	FOXP1	forkhead box P1	23093	0.23
chr6_131889933_131890084	0.22	ARG1	arginase 1	4276	0.25
chr4_185772755_185773053	0.21	ENSG00000266698	.	640	0.72
chr1_172410212_172410374	0.21	PIGC	phosphatidylinositol glycan anchor biosynthesis, class C	2907	0.24
chr9_95555847_95555998	0.21	ANKRD19P	ankyrin repeat domain 19, pseudogene	15971	0.16
chr7_156842429_156842580	0.21	MNX1-AS1	MNX1 antisense RNA 1 (head to head)	39005	0.12
chr1_63931746_63931897	0.21	ITGB3BP	integrin beta 3 binding protein (beta3-endonexin)	57030	0.09
chr2_42979198_42979349	0.21	OXER1	oxoeicosanoid (OXE) receptor 1	12128	0.21
chr2_68652846_68653082	0.21	FBXO48	F-box protein 48	41426	0.12
chr18_74807316_74807807	0.21	MBP	myelin basic protein	9656	0.29
chr12_132366972_132367123	0.21	ULK1	unc-51 like autophagy activating kinase 1	12149	0.17
chr6_116784453_116784778	0.21	RP1-93H18.6		240	0.83
chr4_48239820_48240029	0.21	TEC	tec protein tyrosine kinase	31957	0.18
chr17_4158247_4158398	0.21	ANKFY1	ankyrin repeat and FYVE domain containing 1	8820	0.18
chr2_207025046_207025348	0.21	EEF1B2	eukaryotic translation elongation factor 1 beta 2	866	0.28
chr14_51292294_51292451	0.21	NIN	ninein (GSK3B interacting protein)	3598	0.17
chr2_28843080_28843618	0.20	PLB1	phospholipase B1	10104	0.21
chr3_154802157_154802308	0.20	MME	membrane metallo-endopeptidase	499	0.88
chr4_79597785_79597936	0.20	ENSG00000238816	.	36606	0.16
chr1_93495068_93495341	0.20	ENSG00000251837	.	2141	0.21
chr1_234899568_234899784	0.20	ENSG00000201638	.	74044	0.11
chr2_198971191_198971372	0.20	PLCL1	phospholipase C-like 1	22745	0.28
chr8_131021838_131021989	0.20	ENSG00000264653	.	1214	0.43
chr8_39806379_39806556	0.20	IDO2	indoleamine 2,3-dioxygenase 2	218	0.93
chr12_57106930_57107081	0.20	NACA	nascent polypeptide-associated complex alpha subunit	6379	0.13
chr2_239295864_239296015	0.20	ENSG00000202099	.	25344	0.14
chr2_128938668_128938819	0.20	UGGT1	UDP-glucose glycoprotein glucosyltransferase 1	1383	0.51
chr1_152022964_152023546	0.20	S100A11	S100 calcium binding protein A11	13744	0.14
chrX_119670283_119670616	0.20	ENSG00000272179	.	7721	0.2
chrX_12928349_12928500	0.20	TLR8-AS1	TLR8 antisense RNA 1	1972	0.31
chr1_168416183_168416334	0.20	ENSG00000207974	.	71496	0.11
chr7_75505515_75505666	0.20	RHBDD2	rhomboid domain containing 2	2676	0.23
chr3_151592281_151592432	0.20	SUCNR1	succinate receptor 1	925	0.64
chr4_14913654_14913805	0.20	CPEB2	cytoplasmic polyadenylation element binding protein 2	90569	0.1
chr20_35470625_35470932	0.20	SOGA1	suppressor of glucose, autophagy associated 1	17498	0.15
chr14_71434574_71434725	0.20	PCNX	pecanex homolog (Drosophila)	45099	0.19
chr1_169572243_169572400	0.19	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	16136	0.19
chr12_95032892_95033043	0.19	TMCC3	transmembrane and coiled-coil domain family 3	11371	0.26
chr3_39291368_39291710	0.19	CX3CR1	chemokine (C-X3-C motif) receptor 1	29986	0.16
chr20_4797995_4798146	0.19	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	2301	0.31
chr8_124145367_124145518	0.19	TBC1D31	TBC1 domain family, member 31	32249	0.11
chr22_17597863_17598182	0.19	CECR6	cat eye syndrome chromosome region, candidate 6	4121	0.17
chr1_60015308_60015459	0.19	FGGY	FGGY carbohydrate kinase domain containing	4207	0.36
chr14_65200681_65201005	0.19	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	3890	0.26
chr7_41525377_41525528	0.19	INHBA-AS1	INHBA antisense RNA 1	208062	0.03
chr1_185390714_185391145	0.19	ENSG00000252407	.	12447	0.26
chr2_46116515_46116666	0.19	PRKCE	protein kinase C, epsilon	111451	0.07
chr20_49073611_49073762	0.19	ENSG00000244376	.	27666	0.17
chr6_160363198_160363349	0.19	IGF2R	insulin-like growth factor 2 receptor	26858	0.17
chr2_135953447_135953598	0.19	ENSG00000208308	.	59324	0.14
chr9_104203183_104203334	0.19	ALDOB	aldolase B, fructose-bisphosphate	5153	0.17
chr11_6742912_6743421	0.19	GVINP1	GTPase, very large interferon inducible pseudogene 1	55	0.96
chr17_42761038_42761322	0.19	CCDC43	coiled-coil domain containing 43	5913	0.13
chr14_65173299_65173599	0.19	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	2134	0.36
chr10_15713490_15713641	0.19	ITGA8	integrin, alpha 8	48559	0.18
chr13_100138979_100139130	0.19	LINC00449	long intergenic non-protein coding RNA 449	14252	0.16
chr2_135165435_135165594	0.19	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	153684	0.04
chr1_175158282_175158496	0.19	KIAA0040	KIAA0040	3501	0.33
chr20_23142717_23142901	0.19	ENSG00000201527	.	1201	0.54
chr3_5054013_5054242	0.19	BHLHE40-AS1	BHLHE40 antisense RNA 1	32481	0.16
chr10_75305750_75305901	0.19	ENSG00000207327	.	16910	0.12
chr14_74365658_74365809	0.19	ZNF410	zinc finger protein 410	4670	0.11
chr22_35725194_35725345	0.19	ENSG00000266320	.	6364	0.17
chr1_229161136_229161564	0.19	RP5-1061H20.5		201959	0.02
chr6_108958559_108958710	0.19	FOXO3	forkhead box O3	18915	0.27
chr2_69006771_69007110	0.18	ARHGAP25	Rho GTPase activating protein 25	4868	0.27
chr18_74138582_74138815	0.18	ZNF516	zinc finger protein 516	47830	0.13
chr11_75488134_75488285	0.18	CTD-2530H12.2		1260	0.29
chr8_20056663_20056818	0.18	ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	1790	0.34
chr4_80499592_80499743	0.18	OR7E94P	olfactory receptor, family 7, subfamily E, member 94 pseudogene	9617	0.31
chr3_151081140_151081291	0.18	P2RY12	purinergic receptor P2Y, G-protein coupled, 12	21385	0.16
chr9_114661606_114661757	0.18	UGCG	UDP-glucose ceramide glucosyltransferase	2635	0.29
chr1_226223326_226223530	0.18	H3F3A	H3 histone, family 3A	26124	0.13
chr2_228354322_228354473	0.18	AGFG1	ArfGAP with FG repeats 1	17309	0.19
chr6_7312394_7312749	0.18	SSR1	signal sequence receptor, alpha	836	0.65
chr10_94002812_94003219	0.18	CPEB3	cytoplasmic polyadenylation element binding protein 3	12	0.98
chr11_63274107_63274394	0.18	LGALS12	lectin, galactoside-binding, soluble, 12	415	0.81
chr8_141114736_141114887	0.18	C8orf17	chromosome 8 open reading frame 17	171395	0.04
chr5_1503133_1503343	0.18	LPCAT1	lysophosphatidylcholine acyltransferase 1	20854	0.2
chr1_155204670_155204827	0.18	ENSG00000216109	.	1880	0.12
chr20_56878561_56878712	0.18	PPP4R1L	protein phosphatase 4, regulatory subunit 1-like	5859	0.21
chr4_185182646_185182797	0.18	ENSG00000221523	.	5863	0.22
chr2_7139293_7139444	0.18	RNF144A	ring finger protein 144A	2297	0.38
chr15_91406561_91406712	0.18	FURIN	furin (paired basic amino acid cleaving enzyme)	5186	0.12
chr6_152269247_152269414	0.18	ESR1	estrogen receptor 1	67538	0.13
chr7_3786961_3787112	0.18	AC011284.3		103620	0.08
chr2_216997149_216997386	0.18	XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	23193	0.18
chrX_10087005_10087156	0.18	CLCN4	chloride channel, voltage-sensitive 4	37944	0.15
chr8_82065263_82065697	0.18	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	41177	0.19
chr16_23877339_23877739	0.18	PRKCB	protein kinase C, beta	28995	0.21
chr8_61609604_61609755	0.18	CHD7	chromodomain helicase DNA binding protein 7	17556	0.26
chr3_43305774_43305925	0.18	SNRK	SNF related kinase	22155	0.18
chr10_134068535_134068686	0.18	STK32C	serine/threonine kinase 32C	52108	0.12
chr13_53601964_53602115	0.18	OLFM4	olfactomedin 4	855	0.75
chr3_17040308_17040567	0.18	PLCL2	phospholipase C-like 2	11549	0.24
chr1_225506705_225506856	0.18	DNAH14	dynein, axonemal, heavy chain 14	68415	0.11
chr17_73965690_73965841	0.18	ACOX1	acyl-CoA oxidase 1, palmitoyl	9009	0.09
chr19_51613185_51613336	0.18	CTU1	cytosolic thiouridylase subunit 1	1633	0.2
chr9_7966540_7966691	0.18	TMEM261	transmembrane protein 261	166548	0.04
chr5_96157488_96157872	0.18	ERAP1	endoplasmic reticulum aminopeptidase 1	13877	0.14
chr2_202322766_202322917	0.17	STRADB	STE20-related kinase adaptor beta	6322	0.19
chr10_11249572_11249747	0.17	RP3-323N1.2		36320	0.17
chr22_19399369_19399520	0.17	HIRA	histone cell cycle regulator	19775	0.1
chr19_41913601_41913801	0.17	BCKDHA	branched chain keto acid dehydrogenase E1, alpha polypeptide	2926	0.12
chr2_103037979_103038143	0.17	IL18RAP	interleukin 18 receptor accessory protein	1915	0.26
chr21_16579711_16579862	0.17	NRIP1	nuclear receptor interacting protein 1	142465	0.05
chr2_85901507_85901658	0.17	SFTPB	surfactant protein B	5718	0.14
chr19_43086596_43086747	0.17	CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8	12411	0.18
chr21_34792697_34792848	0.17	IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	11854	0.16
chr4_15666458_15666609	0.17	FBXL5	F-box and leucine-rich repeat protein 5	5043	0.21
chr9_126440722_126440880	0.17	DENND1A	DENN/MADD domain containing 1A	26471	0.21
chr8_123957813_123957964	0.17	RP11-557C18.3		56912	0.1
chr7_37748458_37748609	0.17	GPR141	G protein-coupled receptor 141	25058	0.2
chr19_42702815_42703281	0.17	ENSG00000265122	.	5818	0.1
chr4_13622958_13623109	0.17	BOD1L1	biorientation of chromosomes in cell division 1-like 1	6314	0.21
chr16_68923648_68923799	0.17	ENSG00000199979	.	4143	0.21
chr7_42947190_42947341	0.17	C7orf25	chromosome 7 open reading frame 25	4244	0.24
chr14_102319181_102319389	0.17	CTD-2017C7.1		13417	0.17
chr21_15916640_15916923	0.17	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	1881	0.42
chr10_30021965_30022179	0.17	SVIL	supervillin	2658	0.33
chr1_109676026_109676177	0.17	KIAA1324	KIAA1324	19324	0.11
chr2_136765754_136765905	0.17	AC093391.2		644	0.76
chr1_6069612_6069763	0.17	KCNAB2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	16673	0.16
chr20_46354413_46354564	0.17	CTD-2653D5.1		47843	0.14
chr4_6687814_6687965	0.17	AC093323.1	Uncharacterized protein	6300	0.15
chr2_109883164_109883315	0.17	ENSG00000265965	.	46842	0.18
chr8_48422326_48422477	0.17	RP11-697N18.4		17558	0.25
chr4_81064069_81064253	0.17	PRDM8	PR domain containing 8	41278	0.16
chr11_27379616_27379767	0.17	CCDC34	coiled-coil domain containing 34	5090	0.29
chr16_84377709_84377860	0.17	ATP2C2	ATPase, Ca++ transporting, type 2C, member 2	24349	0.15
chr11_73131309_73131460	0.17	RP11-809N8.4		15042	0.16
chr10_6436483_6436634	0.17	DKFZP667F0711		44280	0.18
chr5_98276963_98277114	0.17	ENSG00000200351	.	4587	0.25
chr15_72660549_72660700	0.17	HEXA	hexosaminidase A (alpha polypeptide)	7561	0.16
chr2_231074797_231075232	0.17	SP140	SP140 nuclear body protein	7188	0.19
chr2_43643825_43643976	0.17	ENSG00000252804	.	8454	0.29
chr17_53841712_53842007	0.17	PCTP	phosphatidylcholine transfer protein	9238	0.26
chr5_111463867_111464018	0.17	ENSG00000238363	.	33240	0.17
chr14_65460947_65461098	0.16	FNTB	farnesyltransferase, CAAX box, beta	7584	0.12
chr10_3506996_3507147	0.16	RP11-184A2.3		286188	0.01
chr14_55583593_55583744	0.16	LGALS3	lectin, galactoside-binding, soluble, 3	7160	0.23
chr5_42631476_42631627	0.16	GHR	growth hormone receptor	65593	0.13
chrX_30657144_30657355	0.16	GK	glycerol kinase	14227	0.19
chr16_81962423_81962574	0.16	ENSG00000260682	.	33033	0.17
chr13_99931097_99931381	0.16	GPR18	G protein-coupled receptor 18	17241	0.18
chr12_104192450_104192601	0.16	RP11-650K20.2		20863	0.13
chr16_53534714_53534865	0.16	AKTIP	AKT interacting protein	548	0.79
chr12_95042694_95042845	0.16	TMCC3	transmembrane and coiled-coil domain family 3	1569	0.51
chr16_3867727_3867878	0.16	CREBBP	CREB binding protein	36934	0.16
chr17_45995658_45995845	0.16	RP11-6N17.3		14721	0.09
chr15_68507516_68507667	0.16	CALML4	calmodulin-like 4	9174	0.16

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX19

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.1	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0	0.1	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.2	GO:0046398	UDP-glucuronate metabolic process(GO:0046398)
0.0	0.1	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.2	GO:0001878	response to yeast(GO:0001878)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0	0.1	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.1	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.0	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0031034	skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.0	GO:0032803	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.0	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812)
0.0	0.1	GO:0071501	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.0	GO:0002448	mast cell mediated immunity(GO:0002448)
0.0	0.1	GO:0021779	oligodendrocyte cell fate commitment(GO:0021779)
0.0	0.1	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.1	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.0	GO:0031033	myosin filament organization(GO:0031033)
0.0	0.0	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.1	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0	0.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.4	GO:0045576	mast cell activation(GO:0045576)
0.0	0.1	GO:0046449	allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.1	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.0	GO:0060157	urinary bladder development(GO:0060157)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.0	GO:0070508	sterol import(GO:0035376) cholesterol import(GO:0070508)
0.0	0.1	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.0	GO:0045416	positive regulation of interleukin-8 biosynthetic process(GO:0045416)
0.0	0.1	GO:0006107	oxaloacetate metabolic process(GO:0006107)
0.0	0.1	GO:0010872	regulation of cholesterol esterification(GO:0010872)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.1	GO:0033591	response to L-ascorbic acid(GO:0033591)
0.0	0.0	GO:0060751	branch elongation involved in mammary gland duct branching(GO:0060751)
0.0	0.2	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.0	0.0	GO:0034371	chylomicron remodeling(GO:0034371)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.0	GO:0048143	astrocyte activation(GO:0048143)
0.0	0.1	GO:0035608	protein deglutamylation(GO:0035608)
0.0	0.1	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0	0.1	GO:0048679	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.0	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0042119	granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0	0.0	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.2	GO:0098927	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.1	GO:0046477	glycosylceramide catabolic process(GO:0046477)
0.0	0.1	GO:0090598	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0	0.0	GO:0060192	negative regulation of lipoprotein lipase activity(GO:0051005) negative regulation of lipase activity(GO:0060192)
0.0	0.1	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.1	GO:0044245	polysaccharide digestion(GO:0044245)
0.0	0.1	GO:0030540	female genitalia development(GO:0030540)
0.0	0.1	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.0	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.0	GO:0048670	regulation of collateral sprouting(GO:0048670)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.0	GO:0071421	manganese ion transmembrane transport(GO:0071421)
0.0	0.1	GO:0000270	peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.0	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.0	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.0	GO:0034442	plasma lipoprotein particle oxidation(GO:0034441) regulation of lipoprotein oxidation(GO:0034442) negative regulation of lipoprotein oxidation(GO:0034443) regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) lipoprotein modification(GO:0042160) lipoprotein oxidation(GO:0042161)
0.0	0.0	GO:0032212	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.0	GO:0017000	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.0	GO:0043032	positive regulation of macrophage activation(GO:0043032)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.0	GO:0030422	production of siRNA involved in RNA interference(GO:0030422)
0.0	0.0	GO:0048245	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.2	GO:0061077	chaperone-mediated protein folding(GO:0061077)
0.0	0.0	GO:0002098	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.0	GO:0018101	protein citrullination(GO:0018101)
0.0	0.0	GO:1904729	regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.0	0.0	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0031125	rRNA 3'-end processing(GO:0031125)
0.0	0.0	GO:0008614	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.0	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.2	GO:1900077	negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0	0.0	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.0	GO:0033689	negative regulation of osteoblast proliferation(GO:0033689)
0.0	0.0	GO:0043030	regulation of macrophage activation(GO:0043030)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.0	GO:0060732	positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0	0.0	GO:0007042	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.0	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0060678	dichotomous subdivision of terminal units involved in ureteric bud branching(GO:0060678)
0.0	0.0	GO:0060539	diaphragm development(GO:0060539)
0.0	0.1	GO:0045214	sarcomere organization(GO:0045214)
0.0	0.0	GO:1903504	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.0	GO:0045897	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0	0.0	GO:0032375	negative regulation of sterol transport(GO:0032372) negative regulation of cholesterol transport(GO:0032375)
0.0	0.0	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.1	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.0	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0042891	tetracycline transport(GO:0015904) antibiotic transport(GO:0042891) toxin transport(GO:1901998)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	GO:0070695	FHF complex(GO:0070695)
0.1	GO:0043218	compact myelin(GO:0043218)
0.1	GO:0030870	Mre11 complex(GO:0030870)
0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.1	GO:0031332	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	GO:0072487	MSL complex(GO:0072487)
0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	GO:0000800	lateral element(GO:0000800)
0.0	GO:0033270	paranode region of axon(GO:0033270)
0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.1	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1	GO:0042101	T cell receptor complex(GO:0042101)
0.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1	GO:0031143	pseudopodium(GO:0031143)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1	0.3	GO:0070492	oligosaccharide binding(GO:0070492)
0.1	0.2	GO:0051425	PTB domain binding(GO:0051425)
0.1	0.2	GO:0043559	insulin binding(GO:0043559)
0.0	0.2	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.2	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.1	GO:1901567	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.1	GO:0001595	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.2	GO:0042171	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.2	GO:0046965	retinoid X receptor binding(GO:0046965)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.0	GO:0034648	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.1	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.0	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.0	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.0	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.0	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.0	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.0	GO:0036041	long-chain fatty acid binding(GO:0036041)
0.0	0.0	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.0	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0031210	phosphatidylcholine binding(GO:0031210)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.1	GO:0017127	cholesterol transporter activity(GO:0017127)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.0	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.0	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.2	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.2	GO:0050699	WW domain binding(GO:0050699)
0.0	0.0	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.0	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.0	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.1	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.0	GO:0030354	melanin-concentrating hormone activity(GO:0030354)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.0	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.1	GO:0031420	alkali metal ion binding(GO:0031420)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.0	GO:0015137	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.0	GO:0004517	nitric-oxide synthase activity(GO:0004517)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.7	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.5	PID IGF1 PATHWAY	IGF1 pathway
0.4	PID EPO PATHWAY	EPO signaling pathway
0.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.3	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.5	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.5	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.2	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP