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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for TBX21_TBR1

Z-value: 1.12

Motif logo

Transcription factors associated with TBX21_TBR1

Gene Symbol	Gene ID	Gene Info
TBX21 Ensembl NCBI GeneCards UniProt	ENSG00000073861.2	TBX21
TBR1 Ensembl NCBI GeneCards UniProt	ENSG00000136535.10	TBR1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
TBR1	chr2_162270925_162271176	1555	0.353935	-0.75	2.1e-02	Click!
TBR1	chr2_162271248_162271461	1251	0.425636	-0.62	7.4e-02	Click!
TBR1	chr2_162275033_162275920	1070	0.482083	-0.56	1.2e-01	Click!
TBR1	chr2_162271540_162272024	823	0.590259	-0.41	2.7e-01	Click!
TBR1	chr2_162274807_162274958	476	0.786582	-0.39	2.9e-01	Click!
TBX21	chr17_45811208_45811612	800	0.566383	-0.71	3.2e-02	Click!
TBX21	chr17_45810351_45810502	184	0.931071	-0.60	9.0e-02	Click!
TBX21	chr17_45809902_45810290	514	0.735967	-0.54	1.4e-01	Click!
TBX21	chr17_45797428_45797643	13075	0.133272	0.52	1.5e-01	Click!
TBX21	chr17_45794623_45794774	15912	0.127290	0.51	1.6e-01	Click!

Activity of the TBX21_TBR1 motif across conditions

Conditions sorted by the z-value of the TBX21_TBR1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_137661433_137661732	0.83	COL5A1	collagen, type V, alpha 1	54908	0.07
chr7_19289019_19289170	0.59	FERD3L	Fer3-like bHLH transcription factor	104050	0.07
chr13_51250685_51250836	0.57	DLEU7-AS1	DLEU7 antisense RNA 1	131232	0.05
chr9_4967955_4968106	0.53	ENSG00000238362	.	67	0.98
chr10_115234705_115234856	0.53	HABP2	hyaluronan binding protein 2	75816	0.11
chr5_179246518_179247261	0.52	SQSTM1	sequestosome 1	870	0.42
chr7_92533540_92533803	0.52	AC002454.1		49448	0.14
chr7_98438304_98438455	0.52	TMEM130	transmembrane protein 130	26190	0.14
chr2_10120083_10120407	0.52	GRHL1	grainyhead-like 1 (Drosophila)	15189	0.16
chr16_49673318_49673469	0.50	ZNF423	zinc finger protein 423	1370	0.54
chr5_158468567_158468757	0.49	CTD-2363C16.2		55848	0.12
chr16_88703444_88703870	0.49	IL17C	interleukin 17C	1344	0.26
chr9_125836101_125836252	0.48	MIR600HG	MIR600 host gene (non-protein coding)	37268	0.13
chr10_81896535_81896686	0.47	PLAC9	placenta-specific 9	4133	0.22
chr10_127911077_127911372	0.47	ENSG00000222740	.	77073	0.11
chr19_47524229_47524951	0.47	NPAS1	neuronal PAS domain protein 1	447	0.8
chr15_42213065_42213339	0.47	CTD-2382E5.4		413	0.76
chr1_92192523_92192711	0.47	ENSG00000239794	.	103014	0.07
chr20_48768588_48769651	0.45	TMEM189-UBE2V1	TMEM189-UBE2V1 readthrough	1055	0.37
chr9_18255474_18255625	0.45	ADAMTSL1	ADAMTS-like 1	218343	0.02
chr1_186943680_186943831	0.45	PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)	145633	0.05
chr6_52898114_52898299	0.44	FBXO9	F-box protein 9	18583	0.12
chr1_92341726_92342008	0.44	TGFBR3	transforming growth factor, beta receptor III	9799	0.22
chr15_67407119_67407359	0.44	SMAD3	SMAD family member 3	10815	0.24
chr2_232026035_232026231	0.44	ENSG00000201574	.	27957	0.14
chr1_84842738_84842889	0.44	DNASE2B	deoxyribonuclease II beta	21402	0.19
chr15_63846204_63846355	0.43	USP3-AS1	USP3 antisense RNA 1	2390	0.3
chr19_6109054_6110118	0.43	CTB-66B24.1		253	0.82
chr9_130615331_130616090	0.43	ENG	endoglin	1205	0.25
chr2_174844394_174844545	0.42	SP3	Sp3 transcription factor	14039	0.3
chr18_21562114_21562426	0.42	TTC39C	tetratricopeptide repeat domain 39C	10467	0.18
chr9_73004696_73004847	0.42	KLF9	Kruppel-like factor 9	24769	0.22
chr18_59561843_59562473	0.42	RNF152	ring finger protein 152	694	0.82
chr8_71515545_71515696	0.41	ENSG00000238450	.	1147	0.39
chr21_39156823_39156974	0.41	KCNJ6-IT1	KCNJ6 intronic transcript 1 (non-protein coding)	65026	0.13
chr6_2378075_2378226	0.41	ENSG00000266252	.	31719	0.24
chr6_5497710_5497861	0.40	RP1-232P20.1		39477	0.2
chr20_4207508_4207659	0.40	ADRA1D	adrenoceptor alpha 1D	22138	0.19
chr12_115339406_115339557	0.40	ENSG00000252459	.	163972	0.04
chr2_216764593_216764988	0.40	ENSG00000212055	.	21148	0.25
chr5_9197616_9197767	0.39	SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	67966	0.13
chr8_118826933_118827084	0.39	MED30	mediator complex subunit 30	293936	0.01
chr8_100691845_100691996	0.38	ENSG00000243254	.	65614	0.12
chr7_81231515_81231666	0.38	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	160722	0.04
chr5_81644153_81644304	0.38	ATP6AP1L	ATPase, H+ transporting, lysosomal accessory protein 1-like	43062	0.19
chr2_225833361_225833665	0.38	DOCK10	dedicator of cytokinesis 10	21731	0.24
chr20_44470840_44471081	0.38	SNX21	sorting nexin family member 21	8185	0.08
chr2_189847314_189847465	0.38	ENSG00000221502	.	4571	0.25
chr1_9244534_9244685	0.38	ENSG00000207865	.	32773	0.14
chr6_122329509_122329660	0.37	ENSG00000199932	.	203210	0.03
chr9_97623840_97624643	0.37	RP11-49O14.3		37687	0.13
chr8_99170182_99170517	0.37	ENSG00000252558	.	34192	0.13
chr17_48281191_48281342	0.37	COL1A1	collagen, type I, alpha 1	2273	0.19
chr2_33363115_33363266	0.37	LTBP1	latent transforming growth factor beta binding protein 1	3466	0.36
chr22_33104640_33104791	0.37	ENSG00000251890	.	73531	0.1
chr6_85896116_85896267	0.37	NT5E	5'-nucleotidase, ecto (CD73)	263618	0.02
chr3_73552092_73552243	0.36	PDZRN3	PDZ domain containing ring finger 3	28384	0.23
chr11_114004685_114004836	0.36	ENSG00000221112	.	47109	0.15
chr20_48602354_48602703	0.36	SNAI1	snail family zinc finger 1	2992	0.21
chr2_127837970_127838423	0.36	BIN1	bridging integrator 1	26381	0.21
chr9_130607035_130607186	0.36	ENSG00000222455	.	3609	0.1
chr5_169028535_169028686	0.36	SPDL1	spindle apparatus coiled-coil protein 1	10502	0.23
chr4_157417337_157417488	0.36	RP11-171N4.2	Uncharacterized protein	146047	0.04
chr8_97923555_97923739	0.36	CPQ	carboxypeptidase Q	118050	0.06
chr3_27495412_27495563	0.36	SLC4A7	solute carrier family 4, sodium bicarbonate cotransporter, member 7	2758	0.29
chr17_78764049_78764405	0.36	RP11-28G8.1		15205	0.23
chr13_111059030_111059181	0.36	ENSG00000238629	.	7447	0.24
chr9_118294239_118294390	0.35	DEC1	deleted in esophageal cancer 1	390217	0.01
chr1_170699275_170699446	0.35	PRRX1	paired related homeobox 1	66282	0.13
chr1_201666517_201666668	0.35	ENSG00000264802	.	22044	0.12
chr6_19698381_19698532	0.35	ENSG00000200957	.	55696	0.16
chr8_69834557_69834708	0.35	ENSG00000238808	.	188177	0.03
chr11_130641340_130641491	0.35	C11orf44	chromosome 11 open reading frame 44	98564	0.08
chr7_31953119_31953270	0.35	ENSG00000223070	.	119332	0.06
chr10_127799860_127800011	0.35	ENSG00000222740	.	34216	0.2
chr6_112085555_112085706	0.34	FYN	FYN oncogene related to SRC, FGR, YES	4510	0.31
chr15_80800821_80800972	0.34	RP11-379K22.2		54389	0.1
chr12_93830493_93830644	0.34	UBE2N	ubiquitin-conjugating enzyme E2N	4464	0.18
chr3_29805050_29805201	0.34	RBMS3-AS2	RBMS3 antisense RNA 2	120825	0.06
chr7_47130953_47131104	0.34	TNS3	tensin 3	188888	0.03
chr8_25782938_25783089	0.34	EBF2	early B-cell factor 2	37581	0.23
chr1_110407259_110407550	0.34	RP11-195M16.1		21482	0.16
chr3_99964733_99964884	0.34	TBC1D23	TBC1 domain family, member 23	15036	0.17
chr4_129488294_129488445	0.34	ENSG00000238802	.	188812	0.03
chr5_39416035_39416186	0.33	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	8860	0.28
chr1_33861335_33861486	0.33	PHC2	polyhomeotic homolog 2 (Drosophila)	20216	0.14
chr6_75361428_75361579	0.33	ENSG00000264884	.	68056	0.15
chr15_83315771_83316117	0.33	CPEB1	cytoplasmic polyadenylation element binding protein 1	70	0.9
chr11_82723729_82724026	0.33	RAB30	RAB30, member RAS oncogene family	15357	0.16
chr8_49318782_49318933	0.33	ENSG00000252710	.	98267	0.08
chr7_71564515_71564666	0.33	CALN1	calneuron 1	179198	0.03
chr1_206942223_206942745	0.33	IL10	interleukin 10	3355	0.2
chr10_31531410_31531796	0.33	ENSG00000252479	.	16925	0.24
chr2_70063653_70063804	0.32	GMCL1	germ cell-less, spermatogenesis associated 1	6954	0.19
chr17_38500621_38501691	0.32	RARA	retinoic acid receptor, alpha	337	0.77
chr12_63161016_63161167	0.32	ENSG00000200296	.	83590	0.09
chr11_74037423_74037574	0.32	P4HA3	prolyl 4-hydroxylase, alpha polypeptide III	14796	0.16
chr10_4584081_4584405	0.32	ENSG00000207124	.	27099	0.26
chr4_16772520_16772671	0.32	LDB2	LIM domain binding 2	96659	0.09
chr8_115801745_115802000	0.32	TRPS1	trichorhinophalangeal syndrome I	702576	0.0
chr6_82853338_82853489	0.32	ENSG00000223044	.	66744	0.13
chr6_113917736_113917887	0.32	ENSG00000266650	.	6306	0.29
chr1_59833983_59834134	0.32	FGGY	FGGY carbohydrate kinase domain containing	58299	0.17
chr2_205427065_205427216	0.32	PARD3B	par-3 family cell polarity regulator beta	16417	0.31
chr13_110936382_110936533	0.32	COL4A2	collagen, type IV, alpha 2	21702	0.2
chr7_18818490_18818641	0.31	ENSG00000222164	.	29337	0.24
chr11_70228081_70228232	0.31	PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	3972	0.15
chr6_151151372_151151523	0.31	MTHFD1L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	35238	0.2
chr6_109036108_109036376	0.31	FOXO3	forkhead box O3	58693	0.15
chr17_7619989_7620737	0.31	DNAH2	dynein, axonemal, heavy chain 2	309	0.79
chr18_52551970_52552121	0.31	RAB27B	RAB27B, member RAS oncogene family	457	0.85
chr17_13496614_13496765	0.31	HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	8555	0.26
chr17_18884424_18884575	0.31	FAM83G	family with sequence similarity 83, member G	3298	0.16
chr11_28785290_28785441	0.31	ENSG00000222385	.	502299	0.0
chr2_133157691_133157842	0.31	ENSG00000252705	.	6665	0.23
chr10_11567375_11567526	0.31	USP6NL	USP6 N-terminal like	6824	0.3
chr11_76377738_76377889	0.31	LRRC32	leucine rich repeat containing 32	3231	0.23
chr11_48190887_48191038	0.31	OR4B1	olfactory receptor, family 4, subfamily B, member 1	47382	0.13
chr12_50747324_50747475	0.31	FAM186A	family with sequence similarity 186, member A	2731	0.25
chr2_161145408_161145559	0.30	ITGB6	integrin, beta 6	88668	0.08
chr12_15906997_15907148	0.30	EPS8	epidermal growth factor receptor pathway substrate 8	25873	0.23
chr16_640639_641593	0.30	RAB40C	RAB40C, member RAS oncogene family	784	0.37
chr12_47025316_47025467	0.30	SLC38A4	solute carrier family 38, member 4	137696	0.05
chr10_133742826_133742977	0.30	PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	5054	0.29
chr2_19808775_19808926	0.30	OSR1	odd-skipped related transciption factor 1	250436	0.02
chr15_74862566_74862717	0.30	ARID3B	AT rich interactive domain 3B (BRIGHT-like)	25950	0.13
chr4_139977093_139977244	0.30	ENSG00000252503	.	539	0.72
chr1_53914957_53915108	0.30	DMRTB1	DMRT-like family B with proline-rich C-terminal, 1	10040	0.24
chr13_27538481_27538780	0.30	USP12-AS1	USP12 antisense RNA 1	198362	0.02
chr1_32769895_32770046	0.30	HDAC1	histone deacetylase 1	11977	0.1
chr5_154076866_154077017	0.30	ENSG00000263478	.	6403	0.16
chr17_40293813_40294053	0.29	RAB5C	RAB5C, member RAS oncogene family	5431	0.11
chr12_63139988_63140139	0.29	ENSG00000238475	.	95108	0.07
chr20_30347823_30347974	0.29	TPX2	TPX2, microtubule-associated	20824	0.13
chr12_99148330_99148481	0.29	APAF1	apoptotic peptidase activating factor 1	106267	0.06
chr16_27412738_27413374	0.29	IL21R	interleukin 21 receptor	427	0.85
chr11_74742638_74742916	0.29	NEU3	sialidase 3 (membrane sialidase)	42787	0.11
chr6_10413127_10413925	0.29	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	414	0.77
chr9_16000333_16000484	0.29	C9orf92	chromosome 9 open reading frame 92	215489	0.02
chr7_38027211_38027362	0.29	SFRP4	secreted frizzled-related protein 4	38011	0.19
chr2_189159021_189159172	0.29	GULP1	GULP, engulfment adaptor PTB domain containing 1	551	0.77
chr11_46315736_46316001	0.29	CREB3L1	cAMP responsive element binding protein 3-like 1	809	0.61
chr10_73523497_73523780	0.29	C10orf54	chromosome 10 open reading frame 54	6251	0.2
chr7_36344154_36344305	0.29	EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	7476	0.18
chr2_45581409_45581560	0.29	SRBD1	S1 RNA binding domain 1	213670	0.02
chr17_80551323_80552124	0.29	RP13-638C3.3		5436	0.11
chr7_17541784_17541935	0.29	ENSG00000199473	.	128909	0.06
chr4_16933226_16933377	0.29	LDB2	LIM domain binding 2	32869	0.25
chr3_23365897_23366271	0.29	ENSG00000206728	.	50786	0.15
chr4_120573726_120573877	0.29	PDE5A	phosphodiesterase 5A, cGMP-specific	23655	0.24
chr7_46427706_46427857	0.29	AC011294.3	Uncharacterized protein	308939	0.01
chr6_1696664_1696815	0.29	FOXC1	forkhead box C1	86058	0.1
chr6_57107845_57107996	0.29	RAB23	RAB23, member RAS oncogene family	20842	0.2
chr9_91144416_91144843	0.28	NXNL2	nucleoredoxin-like 2	5387	0.32
chr11_62286024_62286175	0.28	AHNAK	AHNAK nucleoprotein	17480	0.09
chr17_46138568_46138719	0.28	RP5-890E16.4		612	0.52
chr12_109042760_109042911	0.28	CORO1C	coronin, actin binding protein, 1C	3286	0.17
chr14_92620421_92620697	0.28	CPSF2	cleavage and polyadenylation specific factor 2, 100kDa	964	0.57
chr8_23808938_23809089	0.28	STC1	stanniocalcin 1	96693	0.07
chr12_94661850_94662001	0.28	PLXNC1	plexin C1	5628	0.18
chr8_273706_273857	0.28	FBXO25	F-box protein 25	82647	0.07
chr22_46394064_46394304	0.28	WNT7B	wingless-type MMTV integration site family, member 7B	21175	0.12
chr1_223087898_223088049	0.28	ENSG00000239054	.	2684	0.32
chr5_168521651_168521802	0.28	CTB-174D11.1		64283	0.13
chr20_48601114_48601282	0.28	SNAI1	snail family zinc finger 1	1662	0.32
chr19_39888603_39889701	0.28	MED29	mediator complex subunit 29	7100	0.08
chr5_8730082_8730233	0.28	ENSG00000247516	.	269119	0.02
chr15_38066115_38066266	0.28	TMCO5A	transmembrane and coiled-coil domains 5A	147950	0.05
chr3_115508519_115508795	0.28	ENSG00000243359	.	48058	0.19
chr7_73507529_73508170	0.28	LIMK1	LIM domain kinase 1	440	0.83
chr1_113072667_113072952	0.28	RP4-671G15.2		11746	0.18
chr12_108701464_108701615	0.28	CMKLR1	chemokine-like receptor 1	10155	0.27
chr3_196810256_196810407	0.28	MFI2	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	53644	0.12
chr14_72048409_72048560	0.28	SIPA1L1	signal-induced proliferation-associated 1 like 1	4514	0.34
chr18_72926178_72926329	0.28	TSHZ1	teashirt zinc finger homeobox 1	2769	0.32
chr3_24007488_24007639	0.28	NKIRAS1	NFKB inhibitor interacting Ras-like 1	19481	0.19
chr2_192131267_192131418	0.28	MYO1B	myosin IB	3043	0.35
chr13_41639588_41639739	0.27	WBP4	WW domain binding protein 4	3967	0.19
chr2_144706854_144707005	0.27	AC016910.1		12289	0.26
chr5_65231809_65231960	0.27	ERBB2IP	erbb2 interacting protein	9283	0.24
chr10_31804566_31804717	0.27	RP11-192P3.5		115959	0.06
chr2_189978571_189978722	0.27	AC133106.2		18857	0.19
chr12_13543995_13544146	0.27	C12orf36	chromosome 12 open reading frame 36	3969	0.28
chr12_13442421_13442572	0.27	EMP1	epithelial membrane protein 1	78051	0.09
chr9_111274185_111274336	0.27	ENSG00000222512	.	153051	0.04
chr20_49405055_49405206	0.27	BCAS4	breast carcinoma amplified sequence 4	6301	0.21
chr12_19396388_19396539	0.27	PLEKHA5	pleckstrin homology domain containing, family A member 5	6605	0.25
chr3_105473099_105473371	0.27	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	52190	0.19
chr11_95555093_95555244	0.27	CEP57	centrosomal protein 57kDa	4167	0.24
chr2_19377065_19377216	0.27	ENSG00000266738	.	171050	0.04
chr5_168869708_168869859	0.27	ENSG00000206614	.	109670	0.07
chr14_53386188_53386549	0.27	FERMT2	fermitin family member 2	311	0.93
chr10_80896901_80897550	0.27	ZMIZ1	zinc finger, MIZ-type containing 1	68433	0.12
chr2_46612633_46612855	0.27	ENSG00000241791	.	62906	0.11
chr1_19785123_19785635	0.27	CAPZB	capping protein (actin filament) muscle Z-line, beta	25200	0.14
chr1_221128154_221128305	0.27	HLX	H2.0-like homeobox	73645	0.1
chr20_31147863_31148157	0.26	RP11-410N8.3		885	0.55
chr18_11323846_11323997	0.26	PIEZO2	piezo-type mechanosensitive ion channel component 2	175334	0.03
chr6_56124726_56124877	0.26	COL21A1	collagen, type XXI, alpha 1	12257	0.28
chr7_129563327_129563478	0.26	UBE2H	ubiquitin-conjugating enzyme E2H	27765	0.12

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX21_TBR1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0007132	meiotic metaphase I(GO:0007132)
0.1	0.4	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.3	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1	0.3	GO:0032656	regulation of interleukin-13 production(GO:0032656)
0.1	0.2	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	0.3	GO:0071731	response to nitric oxide(GO:0071731)
0.1	0.3	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.2	GO:0030210	heparin biosynthetic process(GO:0030210)
0.1	0.2	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.1	0.3	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1	0.1	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1	0.3	GO:0048149	behavioral response to ethanol(GO:0048149)
0.1	0.2	GO:0051182	coenzyme transport(GO:0051182)
0.1	0.2	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1	0.2	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1	0.3	GO:0031053	primary miRNA processing(GO:0031053)
0.1	0.2	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.1	0.2	GO:0060594	mammary gland specification(GO:0060594)
0.1	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.1	0.1	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1	0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.1	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.2	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0	0.2	GO:0070091	glucagon secretion(GO:0070091)
0.0	0.1	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.0	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:0052033	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0	0.2	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.1	GO:2000542	negative regulation of gastrulation(GO:2000542)
0.0	0.1	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.4	GO:0048844	artery morphogenesis(GO:0048844)
0.0	0.0	GO:0034776	response to histamine(GO:0034776)
0.0	0.4	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.2	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.2	GO:0032354	response to follicle-stimulating hormone(GO:0032354)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.2	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.2	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.1	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0010665	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.1	GO:0010834	obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.2	GO:0060539	diaphragm development(GO:0060539)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:2000794	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0	0.1	GO:0060492	foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0	0.2	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0045992	negative regulation of embryonic development(GO:0045992)
0.0	0.1	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.4	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.0	0.1	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.1	GO:0014029	neural crest formation(GO:0014029) neural crest cell fate commitment(GO:0014034)
0.0	0.1	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.2	GO:0050901	leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0	0.1	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.4	GO:0035329	hippo signaling(GO:0035329)
0.0	0.0	GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0	0.1	GO:0060900	embryonic camera-type eye formation(GO:0060900)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0061088	regulation of sequestering of zinc ion(GO:0061088)
0.0	0.1	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.2	GO:1901976	regulation of cell cycle checkpoint(GO:1901976)
0.0	0.1	GO:0032730	regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.1	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.3	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.1	GO:1903670	regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.5	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.1	GO:0050775	positive regulation of dendrite morphogenesis(GO:0050775)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.1	GO:0001779	natural killer cell differentiation(GO:0001779)
0.0	0.1	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.1	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.2	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.1	GO:0016115	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.1	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.0	0.0	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.2	GO:0010984	regulation of lipoprotein particle clearance(GO:0010984)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0045779	negative regulation of bone resorption(GO:0045779) negative regulation of bone remodeling(GO:0046851)
0.0	0.1	GO:0045606	positive regulation of epidermal cell differentiation(GO:0045606)
0.0	0.1	GO:0032099	negative regulation of appetite(GO:0032099)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.2	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.1	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.6	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.3	GO:0045773	positive regulation of axon extension(GO:0045773)
0.0	0.0	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.1	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.2	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0045885	obsolete positive regulation of survival gene product expression(GO:0045885)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.0	GO:0039656	modulation by virus of host gene expression(GO:0039656)
0.0	0.0	GO:0060856	establishment of blood-brain barrier(GO:0060856)
0.0	0.0	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.0	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.1	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	0.0	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.1	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.0	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.0	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.3	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.1	GO:0039692	single stranded viral RNA replication via double stranded DNA intermediate(GO:0039692) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0	0.0	GO:0001845	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.1	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.1	GO:0043129	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.0	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0045684	positive regulation of epidermis development(GO:0045684)
0.0	0.1	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.0	0.3	GO:0007528	neuromuscular junction development(GO:0007528)
0.0	0.1	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.1	GO:0048535	lymph node development(GO:0048535)
0.0	0.1	GO:2000831	corticosteroid hormone secretion(GO:0035930) regulation of steroid hormone secretion(GO:2000831) regulation of corticosteroid hormone secretion(GO:2000846)
0.0	0.1	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0	0.0	GO:0032413	negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0	0.4	GO:0016236	macroautophagy(GO:0016236)
0.0	0.1	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.1	GO:0001840	neural plate morphogenesis(GO:0001839) neural plate development(GO:0001840)
0.0	0.1	GO:0008089	anterograde axonal transport(GO:0008089)
0.0	0.1	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.1	GO:0043032	positive regulation of macrophage activation(GO:0043032)
0.0	0.0	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.2	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0000101	sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.0	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.0	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.0	0.0	GO:0032105	negative regulation of response to food(GO:0032096) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.0	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.0	GO:0019859	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.0	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.1	GO:0006911	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.0	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.0	0.2	GO:0045446	endothelial cell differentiation(GO:0045446)
0.0	0.0	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.0	GO:0007097	nuclear migration(GO:0007097)
0.0	0.0	GO:0031620	regulation of fever generation(GO:0031620) positive regulation of fever generation(GO:0031622)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.1	GO:0010896	regulation of triglyceride catabolic process(GO:0010896)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.0	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.0	GO:0032261	purine nucleotide salvage(GO:0032261)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.0	GO:0032119	sequestering of zinc ion(GO:0032119)
0.0	0.0	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0	0.1	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.1	GO:0015824	proline transport(GO:0015824)
0.0	0.0	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.0	GO:0071294	cellular response to zinc ion(GO:0071294)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.2	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.0	0.0	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.0	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.0	GO:0090178	regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0	0.0	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.0	GO:0009648	photoperiodism(GO:0009648)
0.0	0.0	GO:0018243	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.0	GO:0060253	negative regulation of glial cell proliferation(GO:0060253)
0.0	0.0	GO:0060023	soft palate development(GO:0060023)
0.0	0.2	GO:0048286	lung alveolus development(GO:0048286)
0.0	0.0	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.0	GO:0031646	positive regulation of neurological system process(GO:0031646)
0.0	0.0	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	0.0	GO:2000171	negative regulation of dendrite development(GO:2000171)
0.0	0.1	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.0	GO:0010875	positive regulation of cholesterol efflux(GO:0010875)
0.0	0.0	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.1	GO:0006878	cellular copper ion homeostasis(GO:0006878)
0.0	0.0	GO:0007184	SMAD protein import into nucleus(GO:0007184)
0.0	0.0	GO:0006188	IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.0	0.0	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.0	GO:0032347	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347) regulation of steroid hormone biosynthetic process(GO:0090030)
0.0	0.1	GO:0035195	gene silencing by miRNA(GO:0035195)
0.0	0.1	GO:0046653	tetrahydrofolate metabolic process(GO:0046653)
0.0	0.2	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.0	0.1	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.0	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.0	GO:0006545	glycine biosynthetic process(GO:0006545)
0.0	0.0	GO:0070570	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.1	GO:0035510	DNA dealkylation(GO:0035510)
0.0	0.0	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.0	GO:0000154	rRNA modification(GO:0000154)
0.0	0.0	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.0	GO:0090025	regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0	0.3	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.0	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.0	GO:0060437	lung growth(GO:0060437)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005588	collagen type V trimer(GO:0005588)
0.1	0.2	GO:0043259	laminin-10 complex(GO:0043259)
0.1	0.5	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	0.2	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.4	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.4	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.2	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.2	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.2	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.3	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.0	GO:0098651	basement membrane collagen trimer(GO:0098651)
0.0	0.2	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.2	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.2	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.1	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	1.9	GO:0005925	focal adhesion(GO:0005925)
0.0	0.1	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.2	GO:0031231	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	0.2	GO:0005858	axonemal dynein complex(GO:0005858)
0.0	0.0	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0016011	dystroglycan complex(GO:0016011)
0.0	0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.0	GO:0031904	endosome lumen(GO:0031904)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.2	GO:0008278	cohesin complex(GO:0008278)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.0	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.2	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.2	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.1	GO:0005581	collagen trimer(GO:0005581)
0.0	0.0	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.1	GO:0042824	MHC class I peptide loading complex(GO:0042824)
0.0	0.0	GO:0042597	outer membrane-bounded periplasmic space(GO:0030288) periplasmic space(GO:0042597)
0.0	0.0	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.0	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.0	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	0.0	GO:0002141	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.1	GO:0030677	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.4	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.1	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.8	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	0.2	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.7	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.1	0.3	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.1	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.1	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.2	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.5	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.6	GO:1990782	receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.1	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.3	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	1.0	GO:0017048	Rho GTPase binding(GO:0017048)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.2	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.1	GO:0016406	carnitine O-acyltransferase activity(GO:0016406)
0.0	0.1	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.2	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.1	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.1	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.7	GO:0005518	collagen binding(GO:0005518)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.2	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.4	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.2	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.2	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	0.0	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.0	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.0	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.2	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.0	0.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.2	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.0	GO:1990939	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0	0.1	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.1	GO:0051378	serotonin binding(GO:0051378)
0.0	0.0	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0070063	RNA polymerase binding(GO:0070063)
0.0	0.1	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.0	0.1	GO:0031210	phosphatidylcholine binding(GO:0031210)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.0	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0016742	hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0	0.1	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	0.0	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.0	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.0	0.1	GO:0004082	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.2	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.0	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.1	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.1	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.2	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.0	0.1	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.1	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.0	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.1	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.1	GO:0008271	secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0	0.0	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.1	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.0	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.1	GO:0015197	peptide transporter activity(GO:0015197)
0.0	0.0	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.0	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.0	GO:0031013	troponin I binding(GO:0031013)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0015211	purine nucleoside transmembrane transporter activity(GO:0015211)
0.0	0.1	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.1	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0	0.0	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.7	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0030515	snoRNA binding(GO:0030515)
0.0	0.0	GO:0034584	piRNA binding(GO:0034584)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.0	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.1	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.1	GO:0033613	activating transcription factor binding(GO:0033613)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.8	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
1.5	NABA COLLAGENS	Genes encoding collagen proteins
0.0	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.7	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.2	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.3	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.4	PID AURORA A PATHWAY	Aurora A signaling
0.0	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.7	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.3	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.3	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.2	PID REELIN PATHWAY	Reelin signaling pathway
0.0	ST G ALPHA I PATHWAY	G alpha i Pathway
0.2	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.6	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.4	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.3	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.4	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.4	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	REACTOME P75NTR SIGNALS VIA NFKB	Genes involved in p75NTR signals via NF-kB
0.9	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.1	REACTOME SHC RELATED EVENTS	Genes involved in SHC-related events
0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.1	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.7	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.5	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.1	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.2	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.2	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.2	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.1	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.1	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation