Project
ENCODE: H3K4me1 ChIP-Seq of primary human cells
Navigation
Downloads
Logo
CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for TBX4

Z-value: 0.31

Motif logo

logo of

Transcription factors associated with TBX4

Gene Symbol Gene ID Gene Info
TBX4
ENSG00000121075.5 TBX4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
TBX4chr17_59534235_595344935570.716020-0.844.7e-03Click!
TBX4chr17_59534639_5953499410090.480485-0.703.7e-02Click!
TBX4chr17_59535127_5953532814200.357722-0.541.4e-01Click!
TBX4chr17_59529466_595296542050.923279-0.531.4e-01Click!
TBX4chr17_59533558_595337091740.937318-0.482.0e-01Click!

Activity of the TBX4 motif across conditions

Conditions sorted by the z-value of the TBX4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr10_4584081_4584405 0.17 ENSG00000207124
 .
 27099
 0.26
chr2_65065663_65065834 0.11 ENSG00000199964
 .
 4457
 0.21
chr8_71515545_71515696 0.10 ENSG00000238450
 .
 1147
 0.39
chr8_49228853_49229154 0.09 ENSG00000252710
 .
 8413
 0.32
chr11_61448106_61448684 0.09 DAGLA
 diacylglycerol lipase, alpha
 490
 0.8
chr11_2117665_2117864 0.08 ENSG00000207805
 .
 37675
 0.09
chr15_62737179_62737605 0.07 TLN2
 talin 2
 116172
 0.06
chr1_52435800_52436083 0.07 ENSG00000200839
 .
 3141
 0.18
chr11_74742638_74742916 0.07 NEU3
 sialidase 3 (membrane sialidase)
 42787
 0.11
chr9_91144416_91144843 0.07 NXNL2
 nucleoredoxin-like 2
 5387
 0.32
chr1_22253677_22253895 0.07 HSPG2
 heparan sulfate proteoglycan 2
 10004
 0.15
chr8_99170182_99170517 0.07 ENSG00000252558
 .
 34192
 0.13
chr1_22252730_22253001 0.07 HSPG2
 heparan sulfate proteoglycan 2
 10925
 0.15
chr11_86458885_86459036 0.07 PRSS23
 protease, serine, 23
 43141
 0.18
chr20_4207508_4207659 0.07 ADRA1D
 adrenoceptor alpha 1D
 22138
 0.19
chr3_42078593_42078744 0.06 TRAK1
 trafficking protein, kinesin binding 1
 53894
 0.14
chr12_63139988_63140139 0.06 ENSG00000238475
 .
 95108
 0.07
chr13_34931777_34932168 0.06 ENSG00000199196
 .
 256997
 0.02
chr3_64172202_64172494 0.06 PRICKLE2-AS3
 PRICKLE2 antisense RNA 3
 872
 0.63
chr3_193988294_193988600 0.06 CPN2
 carboxypeptidase N, polypeptide 2
 83600
 0.08
chr3_8580450_8580601 0.06 LMCD1
 LIM and cysteine-rich domains 1
 1656
 0.43
chr2_45581409_45581560 0.06 SRBD1
 S1 RNA binding domain 1
 213670
 0.02
chr5_178703659_178703833 0.06 ADAMTS2
 ADAM metallopeptidase with thrombospondin type 1 motif, 2
 68685
 0.12
chr19_42592250_42592591 0.06 POU2F2
 POU class 2 homeobox 2
 7137
 0.11
chr5_171288121_171288370 0.06 SMIM23
 small integral membrane protein 23
 75355
 0.09
chr3_159338407_159338558 0.06 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
 143020
 0.04
chr5_64493902_64494516 0.06 ENSG00000207439
 .
 75013
 0.12
chr14_105439124_105439578 0.06 AHNAK2
 AHNAK nucleoprotein 2
 5343
 0.17
chr2_217640205_217640356 0.06 ENSG00000222832
 .
 18043
 0.18
chr11_44010465_44010739 0.06 C11orf96
 chromosome 11 open reading frame 96
 46547
 0.11
chrX_150958201_150958352 0.06 CNGA2
 cyclic nucleotide gated channel alpha 2
 51353
 0.13
chr10_64386237_64386388 0.06 ZNF365
 zinc finger protein 365
 17221
 0.23
chr16_29836315_29836998 0.06 MVP
 major vault protein
 4010
 0.08
chr1_66291138_66291289 0.06 PDE4B
 phosphodiesterase 4B, cAMP-specific
 32349
 0.21
chr7_36344154_36344305 0.06 EEPD1
 endonuclease/exonuclease/phosphatase family domain containing 1
 7476
 0.18
chr15_34348811_34348962 0.06 AVEN
 apoptosis, caspase activation inhibitor
 17509
 0.17
chr1_240399314_240399591 0.06 FMN2
 formin 2
 9108
 0.25
chr4_169449939_169450239 0.06 PALLD
 palladin, cytoskeletal associated protein
 17370
 0.21
chr12_16119043_16119194 0.06 DERA
 deoxyribose-phosphate aldolase (putative)
 9596
 0.27
chr1_201666517_201666668 0.06 ENSG00000264802
 .
 22044
 0.12
chr20_42161917_42162068 0.06 L3MBTL1
 l(3)mbt-like 1 (Drosophila)
 4645
 0.17
chr4_156726912_156727063 0.06 GUCY1B3
 guanylate cyclase 1, soluble, beta 3
 46376
 0.13
chr15_42213065_42213339 0.06 CTD-2382E5.4
413
 0.76
chr3_187800607_187800758 0.06 LPP
 LIM domain containing preferred translocation partner in lipoma
 70390
 0.11
chr16_87615099_87615250 0.06 RP11-482M8.3
20622
 0.17
chr1_170675865_170676016 0.06 PRRX1
 paired related homeobox 1
 42862
 0.19
chr1_109045119_109045270 0.06 NBPF6
 neuroblastoma breakpoint family, member 6
 52251
 0.14
chr6_169497993_169498144 0.06 XXyac-YX65C7_A.2
115281
 0.07
chr2_20290862_20291052 0.06 RP11-644K8.1
39062
 0.13
chr13_50931215_50931366 0.06 ENSG00000221198
 .
 6083
 0.33
chr14_100435801_100435952 0.06 EVL
 Enah/Vasp-like
 1910
 0.34
chr17_48281191_48281342 0.06 COL1A1
 collagen, type I, alpha 1
 2273
 0.19
chr1_235044220_235044371 0.06 ENSG00000239690
 .
 4362
 0.31
chr3_11739592_11739743 0.06 VGLL4
 vestigial like 4 (Drosophila)
 12344
 0.26
chr20_48768588_48769651 0.06 TMEM189-UBE2V1
 TMEM189-UBE2V1 readthrough
 1055
 0.37
chr11_46293650_46293801 0.06 CTD-2589M5.4
2373
 0.27
chr8_119820459_119820610 0.06 TNFRSF11B
 tumor necrosis factor receptor superfamily, member 11b
 143905
 0.05
chr3_73552092_73552243 0.06 PDZRN3
 PDZ domain containing ring finger 3
 28384
 0.23
chr1_84842738_84842889 0.06 DNASE2B
 deoxyribonuclease II beta
 21402
 0.19
chr16_59670319_59670470 0.06 ENSG00000200062
 .
 96364
 0.09
chr9_116394736_116394887 0.06 RGS3
 regulator of G-protein signaling 3
 39045
 0.17
chr3_187989157_187989308 0.06 LPP
 LIM domain containing preferred translocation partner in lipoma
 31580
 0.22
chr6_144007887_144008177 0.06 PHACTR2
 phosphatase and actin regulator 2
 8827
 0.27
chr1_51730316_51730746 0.06 RP11-296A18.6
1215
 0.4
chr12_52575126_52575277 0.06 KRT80
 keratin 80
 10583
 0.13
chr11_123460981_123461132 0.06 GRAMD1B
 GRAM domain containing 1B
 17461
 0.21
chr6_33580965_33581212 0.06 ITPR3
 inositol 1,4,5-trisphosphate receptor, type 3
 7054
 0.14
chr2_227624493_227624644 0.06 IRS1
 insulin receptor substrate 1
 39907
 0.16
chr3_49842732_49843503 0.06 ENSG00000263506
 .
 561
 0.55
chr11_2333873_2334024 0.06 ENSG00000207308
 .
 9000
 0.12
chr16_88703444_88703870 0.06 IL17C
 interleukin 17C
 1344
 0.26
chr3_123838707_123838915 0.06 ENSG00000266383
 .
 12965
 0.21
chr3_149325355_149325506 0.06 WWTR1
 WW domain containing transcription regulator 1
 31391
 0.15
chr9_112942282_112942517 0.06 C9orf152
 chromosome 9 open reading frame 152
 28070
 0.2
chr20_10963665_10963956 0.06 RP11-103J8.1
3513
 0.34
chr5_139069430_139069742 0.05 CXXC5
 CXXC finger protein 5
 10318
 0.2
chr10_126745390_126745757 0.05 ENSG00000264572
 .
 24134
 0.19
chr2_129063259_129063630 0.05 HS6ST1
 heparan sulfate 6-O-sulfotransferase 1
 12707
 0.24
chr6_19698381_19698532 0.05 ENSG00000200957
 .
 55696
 0.16
chr12_47025316_47025467 0.05 SLC38A4
 solute carrier family 38, member 4
 137696
 0.05
chr10_22723256_22723780 0.05 RP11-301N24.3
73417
 0.1
chr8_118826933_118827084 0.05 MED30
 mediator complex subunit 30
 293936
 0.01
chr2_133157691_133157842 0.05 ENSG00000252705
 .
 6665
 0.23
chr11_74037423_74037574 0.05 P4HA3
 prolyl 4-hydroxylase, alpha polypeptide III
 14796
 0.16
chr17_15224796_15224947 0.05 ENSG00000200437
 .
 10209
 0.17
chr3_154688977_154689233 0.05 MME
 membrane metallo-endopeptidase
 52808
 0.18
chr4_120573726_120573877 0.05 PDE5A
 phosphodiesterase 5A, cGMP-specific
 23655
 0.24
chr3_99129524_99129675 0.05 ENSG00000266030
 .
 43866
 0.2
chr8_99164226_99164377 0.05 POP1
 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
 34233
 0.13
chr11_70634178_70634329 0.05 SHANK2
 SH3 and multiple ankyrin repeat domains 2
 38392
 0.16
chr2_69449091_69449242 0.05 ENSG00000199460
 .
 39157
 0.15
chr6_122329509_122329660 0.05 ENSG00000199932
 .
 203210
 0.03
chr10_125689568_125689719 0.05 RP11-285A18.2
1470
 0.43
chr13_111059030_111059181 0.05 ENSG00000238629
 .
 7447
 0.24
chr7_90447196_90447347 0.05 CDK14
 cyclin-dependent kinase 14
 108095
 0.07
chrX_119003137_119003794 0.05 NDUFA1
 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
 1985
 0.21
chr8_123607926_123608077 0.05 ENSG00000238901
 .
 75529
 0.12
chr14_51974464_51974948 0.05 ENSG00000252400
 .
 14876
 0.21
chr3_55367534_55367685 0.05 WNT5A
 wingless-type MMTV integration site family, member 5A
 147615
 0.05
chr21_44922828_44923116 0.05 SIK1
 salt-inducible kinase 1
 75964
 0.1
chr2_216764593_216764988 0.05 ENSG00000212055
 .
 21148
 0.25
chr22_46402793_46403252 0.05 WNT7B
 wingless-type MMTV integration site family, member 7B
 30013
 0.1
chr2_46612633_46612855 0.05 ENSG00000241791
 .
 62906
 0.11
chr2_216613985_216614378 0.05 ENSG00000212055
 .
 129461
 0.05
chr14_94587792_94587943 0.05 IFI27L2
 interferon, alpha-inducible protein 27-like 2
 8134
 0.15
chr15_52935123_52935274 0.05 RP11-519C12.1
6865
 0.2
chr9_118294239_118294390 0.05 DEC1
 deleted in esophageal cancer 1
 390217
 0.01
chr6_158506907_158507345 0.05 SYNJ2
 synaptojanin 2
 8414
 0.21
chr9_130615331_130616090 0.05 ENG
 endoglin
 1205
 0.25
chr6_140075327_140075478 0.05 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
 379645
 0.01
chr18_11323846_11323997 0.05 PIEZO2
 piezo-type mechanosensitive ion channel component 2
 175334
 0.03
chr11_95555093_95555244 0.05 CEP57
 centrosomal protein 57kDa
 4167
 0.24
chr3_99964733_99964884 0.05 TBC1D23
 TBC1 domain family, member 23
 15036
 0.17
chr15_66938215_66938421 0.05 SMAD6
 SMAD family member 6
 56248
 0.1
chr1_183041587_183041738 0.05 LAMC1
 laminin, gamma 1 (formerly LAMB2)
 24017
 0.19
chr10_63553300_63553451 0.05 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 107684
 0.07
chr10_15336257_15336446 0.05 RP11-25G10.2
56860
 0.13
chr6_151151372_151151523 0.05 MTHFD1L
 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
 35238
 0.2
chr17_13496614_13496765 0.05 HS3ST3A1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
 8555
 0.26
chr7_134380957_134381211 0.05 BPGM
 2,3-bisphosphoglycerate mutase
 35911
 0.18
chr6_36216557_36216942 0.05 PNPLA1
 patatin-like phospholipase domain containing 1
 5769
 0.2
chr17_75251415_75251576 0.05 SEPT9
 septin 9
 25156
 0.19
chr11_69325521_69325672 0.05 CCND1
 cyclin D1
 130259
 0.05
chr6_85787065_85787216 0.05 TBX18
 T-box 18
 312903
 0.01
chr11_70228081_70228232 0.05 PPFIA1
 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
 3972
 0.15
chr11_130761204_130761355 0.05 SNX19
 sorting nexin 19
 2490
 0.42
chr3_66456383_66456534 0.05 ENSG00000241587
 .
 82179
 0.1
chr12_2394240_2394442 0.05 CACNA1C-IT3
 CACNA1C intronic transcript 3 (non-protein coding)
 15399
 0.25
chr9_98260446_98260655 0.05 RP11-435O5.6
3344
 0.21
chr1_21066214_21066365 0.05 RP5-930J4.4
3191
 0.17
chr20_45754813_45755050 0.05 ENSG00000264901
 .
 40678
 0.18
chr14_53301825_53302222 0.05 FERMT2
 fermitin family member 2
 29216
 0.15
chr9_74545305_74545456 0.05 C9orf85
 chromosome 9 open reading frame 85
 18803
 0.18
chr2_40327696_40327847 0.05 SLC8A1-AS1
 SLC8A1 antisense RNA 1
 4278
 0.36
chr5_171845939_171846090 0.05 ENSG00000216127
 .
 20744
 0.2
chr16_86696225_86696376 0.05 FOXL1
 forkhead box L1
 84185
 0.08
chr1_235097341_235097798 0.05 ENSG00000239690
 .
 57636
 0.14
chr1_113067186_113067337 0.05 RP4-671G15.2
6198
 0.2
chr7_94040475_94040626 0.05 COL1A2
 collagen, type I, alpha 2
 16677
 0.25
chr3_29724640_29724791 0.05 RBMS3-AS2
 RBMS3 antisense RNA 2
 40415
 0.22
chr7_72421339_72421490 0.05 NSUN5P2
 NOP2/Sun domain family, member 5 pseudogene 2
 3842
 0.13
chr5_39416035_39416186 0.05 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
 8860
 0.28
chr10_81896535_81896686 0.05 PLAC9
 placenta-specific 9
 4133
 0.22
chr10_97033802_97033953 0.05 PDLIM1
 PDZ and LIM domain 1
 16904
 0.21
chr6_2378075_2378226 0.05 ENSG00000266252
 .
 31719
 0.24
chr22_33104640_33104791 0.05 ENSG00000251890
 .
 73531
 0.1
chr19_19458792_19458943 0.05 MAU2
 MAU2 sister chromatid cohesion factor
 10852
 0.13
chr6_38315124_38315275 0.05 ENSG00000238716
 .
 11806
 0.28
chr8_70555415_70555566 0.05 ENSG00000222889
 .
 56969
 0.13
chr2_9450145_9450296 0.05 ASAP2
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
 103326
 0.06
chr2_134599157_134599414 0.05 ENSG00000200708
 .
 245623
 0.02
chr17_19233901_19234052 0.05 RP11-135L13.4
5464
 0.12
chr1_206687145_206687296 0.05 RASSF5
 Ras association (RalGDS/AF-6) domain family member 5
 6341
 0.15
chr4_189862800_189862951 0.05 ENSG00000252275
 .
 224996
 0.02
chr3_106329448_106329599 0.05 ENSG00000200361
 .
 78002
 0.11
chr17_59310548_59310699 0.05 RP11-136H19.1
97298
 0.07
chr8_6344138_6344289 0.05 ANGPT2
 angiopoietin 2
 76352
 0.1
chr22_31039864_31040015 0.05 SLC35E4
 solute carrier family 35, member E4
 7429
 0.13
chr11_10139098_10139249 0.05 RP11-748C4.1
31566
 0.21
chr2_33363115_33363266 0.05 LTBP1
 latent transforming growth factor beta binding protein 1
 3466
 0.36
chr16_73156371_73156706 0.05 C16orf47
 chromosome 16 open reading frame 47
 21808
 0.23
chr6_52392885_52393036 0.05 TRAM2
 translocation associated membrane protein 2
 48753
 0.15
chr2_190030887_190031038 0.05 COL5A2
 collagen, type V, alpha 2
 13643
 0.22
chr7_98438304_98438455 0.05 TMEM130
 transmembrane protein 130
 26190
 0.14
chr8_24206460_24207135 0.05 ADAM28
 ADAM metallopeptidase domain 28
 7632
 0.22
chr10_80838963_80839341 0.05 ZMIZ1
 zinc finger, MIZ-type containing 1
 10360
 0.24
chr1_223083321_223083472 0.05 ENSG00000239054
 .
 1893
 0.4
chr9_104277002_104277153 0.05 TMEM246
 transmembrane protein 246
 18653
 0.14
chr1_6803545_6803777 0.05 ENSG00000239166
 .
 9118
 0.17
chr10_31531410_31531796 0.05 ENSG00000252479
 .
 16925
 0.24
chr6_64516560_64517136 0.05 RP11-59D5__B.2
119
 0.98
chr16_49673318_49673469 0.05 ZNF423
 zinc finger protein 423
 1370
 0.54
chr1_221437708_221437859 0.05 HLX
 H2.0-like homeobox
 383199
 0.01
chr11_122068067_122068218 0.05 ENSG00000207994
 .
 45126
 0.13
chr11_113323627_113323778 0.05 ENSG00000265140
 .
 2892
 0.24
chr19_38490719_38490870 0.05 CTC-244M17.1
36301
 0.14
chr1_210536298_210536449 0.05 HHAT
 hedgehog acyltransferase
 177
 0.96
chr20_19795494_19795742 0.05 AL121761.2
 Uncharacterized protein
 56939
 0.12
chr2_106010411_106010562 0.05 FHL2
 four and a half LIM domains 2
 2756
 0.27
chr11_77654778_77654929 0.05 INTS4
 integrator complex subunit 4
 32653
 0.12
chr11_131729951_131730102 0.05 AP004372.1
36976
 0.19
chr1_159009390_159009541 0.05 ENSG00000265589
 .
 19574
 0.16
chr10_80713188_80713394 0.05 ZMIZ1-AS1
 ZMIZ1 antisense RNA 1
 8860
 0.31
chr1_856648_857113 0.05 SAMD11
 sterile alpha motif domain containing 11
 3380
 0.14
chr1_53914957_53915108 0.05 DMRTB1
 DMRT-like family B with proline-rich C-terminal, 1
 10040
 0.24
chr11_61772142_61772440 0.05 AP003733.1
 Uncharacterized protein; cDNA FLJ36460 fis, clone THYMU2014801
 36838
 0.11
chr15_63142711_63142998 0.05 RP11-1069G10.1
6074
 0.22
chr2_28884288_28884439 0.05 AC074011.2
3043
 0.24
chr2_10119571_10119722 0.05 GRHL1
 grainyhead-like 1 (Drosophila)
 15788
 0.16
chr6_126135548_126136266 0.05 NCOA7
 nuclear receptor coactivator 7
 457
 0.81
chr18_48596659_48596948 0.05 SMAD4
 SMAD family member 4
 3320
 0.29
chr9_111815301_111815452 0.05 ENSG00000207698
 .
 6798
 0.16
chr14_55603634_55603785 0.05 LGALS3
 lectin, galactoside-binding, soluble, 3
 7731
 0.23
chr16_64447214_64447365 0.05 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 646292
 0.0
chr9_16031542_16031875 0.05 C9orf92
 chromosome 9 open reading frame 92
 184189
 0.03
chr6_38314206_38314357 0.05 ENSG00000238716
 .
 12724
 0.28
chr7_75043431_75043582 0.05 NSUN5P1
 NOP2/Sun domain family, member 5 pseudogene 1
 1676
 0.23
chr19_42781870_42782547 0.05 CIC
 capicua transcriptional repressor
 5964
 0.09
chr6_113468381_113468532 0.05 ENSG00000201386
 .
 175761
 0.03
chr14_71710075_71710226 0.05 AC004817.1
 HCG2028611; Uncharacterized protein
 26688
 0.21

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of TBX4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.0 GO:0035583 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.0 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.0 GO:0045630 positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0 0.0 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0004103 choline kinase activity(GO:0004103)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling