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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for TBX4

Z-value: 0.31

Motif logo

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Transcription factors associated with TBX4

Gene Symbol Gene ID Gene Info
TBX4
ENSG00000121075.5 T-box transcription factor 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr17_59534235_59534493TBX45570.716020-0.844.7e-03Click!
chr17_59534639_59534994TBX410090.480485-0.703.7e-02Click!
chr17_59535127_59535328TBX414200.357722-0.541.4e-01Click!
chr17_59529466_59529654TBX42050.923279-0.531.4e-01Click!
chr17_59533558_59533709TBX41740.937318-0.482.0e-01Click!

Activity of the TBX4 motif across conditions

Conditions sorted by the z-value of the TBX4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr10_4584081_4584405 0.17 ENSG00000207124
 .
 27099
 0.26
chr2_65065663_65065834 0.11 ENSG00000199964
 .
 4457
 0.21
chr8_71515545_71515696 0.10 ENSG00000238450
 .
 1147
 0.39
chr8_49228853_49229154 0.09 ENSG00000252710
 .
 8413
 0.32
chr11_61448106_61448684 0.09 DAGLA
 diacylglycerol lipase, alpha
 490
 0.8
chr11_2117665_2117864 0.08 ENSG00000207805
 .
 37675
 0.09
chr15_62737179_62737605 0.07 TLN2
 talin 2
 116172
 0.06
chr1_52435800_52436083 0.07 ENSG00000200839
 .
 3141
 0.18
chr11_74742638_74742916 0.07 NEU3
 sialidase 3 (membrane sialidase)
 42787
 0.11
chr9_91144416_91144843 0.07 NXNL2
 nucleoredoxin-like 2
 5387
 0.32
chr1_22253677_22253895 0.07 HSPG2
 heparan sulfate proteoglycan 2
 10004
 0.15
chr8_99170182_99170517 0.07 ENSG00000252558
 .
 34192
 0.13
chr1_22252730_22253001 0.07 HSPG2
 heparan sulfate proteoglycan 2
 10925
 0.15
chr11_86458885_86459036 0.07 PRSS23
 protease, serine, 23
 43141
 0.18
chr20_4207508_4207659 0.07 ADRA1D
 adrenoceptor alpha 1D
 22138
 0.19
chr3_42078593_42078744 0.06 TRAK1
 trafficking protein, kinesin binding 1
 53894
 0.14
chr12_63139988_63140139 0.06 ENSG00000238475
 .
 95108
 0.07
chr13_34931777_34932168 0.06 ENSG00000199196
 .
 256997
 0.02
chr3_64172202_64172494 0.06 PRICKLE2-AS3
 PRICKLE2 antisense RNA 3
 872
 0.63
chr3_193988294_193988600 0.06 CPN2
 carboxypeptidase N, polypeptide 2
 83600
 0.08
chr3_8580450_8580601 0.06 LMCD1
 LIM and cysteine-rich domains 1
 1656
 0.43
chr2_45581409_45581560 0.06 SRBD1
 S1 RNA binding domain 1
 213670
 0.02
chr5_178703659_178703833 0.06 ADAMTS2
 ADAM metallopeptidase with thrombospondin type 1 motif, 2
 68685
 0.12
chr19_42592250_42592591 0.06 POU2F2
 POU class 2 homeobox 2
 7137
 0.11
chr5_171288121_171288370 0.06 SMIM23
 small integral membrane protein 23
 75355
 0.09
chr3_159338407_159338558 0.06 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
 143020
 0.04
chr5_64493902_64494516 0.06 ENSG00000207439
 .
 75013
 0.12
chr14_105439124_105439578 0.06 AHNAK2
 AHNAK nucleoprotein 2
 5343
 0.17
chr2_217640205_217640356 0.06 ENSG00000222832
 .
 18043
 0.18
chr11_44010465_44010739 0.06 C11orf96
 chromosome 11 open reading frame 96
 46547
 0.11
chrX_150958201_150958352 0.06 CNGA2
 cyclic nucleotide gated channel alpha 2
 51353
 0.13
chr10_64386237_64386388 0.06 ZNF365
 zinc finger protein 365
 17221
 0.23
chr16_29836315_29836998 0.06 MVP
 major vault protein
 4010
 0.08
chr1_66291138_66291289 0.06 PDE4B
 phosphodiesterase 4B, cAMP-specific
 32349
 0.21
chr7_36344154_36344305 0.06 EEPD1
 endonuclease/exonuclease/phosphatase family domain containing 1
 7476
 0.18
chr15_34348811_34348962 0.06 AVEN
 apoptosis, caspase activation inhibitor
 17509
 0.17
chr1_240399314_240399591 0.06 FMN2
 formin 2
 9108
 0.25
chr4_169449939_169450239 0.06 PALLD
 palladin, cytoskeletal associated protein
 17370
 0.21
chr12_16119043_16119194 0.06 DERA
 deoxyribose-phosphate aldolase (putative)
 9596
 0.27
chr1_201666517_201666668 0.06 ENSG00000264802
 .
 22044
 0.12
chr20_42161917_42162068 0.06 L3MBTL1
 l(3)mbt-like 1 (Drosophila)
 4645
 0.17
chr4_156726912_156727063 0.06 GUCY1B3
 guanylate cyclase 1, soluble, beta 3
 46376
 0.13
chr15_42213065_42213339 0.06 CTD-2382E5.4
413
 0.76
chr3_187800607_187800758 0.06 LPP
 LIM domain containing preferred translocation partner in lipoma
 70390
 0.11
chr16_87615099_87615250 0.06 RP11-482M8.3
20622
 0.17
chr1_170675865_170676016 0.06 PRRX1
 paired related homeobox 1
 42862
 0.19
chr1_109045119_109045270 0.06 NBPF6
 neuroblastoma breakpoint family, member 6
 52251
 0.14
chr6_169497993_169498144 0.06 XXyac-YX65C7_A.2
115281
 0.07
chr2_20290862_20291052 0.06 RP11-644K8.1
39062
 0.13
chr13_50931215_50931366 0.06 ENSG00000221198
 .
 6083
 0.33
chr14_100435801_100435952 0.06 EVL
 Enah/Vasp-like
 1910
 0.34
chr17_48281191_48281342 0.06 COL1A1
 collagen, type I, alpha 1
 2273
 0.19
chr1_235044220_235044371 0.06 ENSG00000239690
 .
 4362
 0.31
chr3_11739592_11739743 0.06 VGLL4
 vestigial like 4 (Drosophila)
 12344
 0.26
chr20_48768588_48769651 0.06 TMEM189-UBE2V1
 TMEM189-UBE2V1 readthrough
 1055
 0.37
chr11_46293650_46293801 0.06 CTD-2589M5.4
2373
 0.27
chr8_119820459_119820610 0.06 TNFRSF11B
 tumor necrosis factor receptor superfamily, member 11b
 143905
 0.05
chr3_73552092_73552243 0.06 PDZRN3
 PDZ domain containing ring finger 3
 28384
 0.23
chr1_84842738_84842889 0.06 DNASE2B
 deoxyribonuclease II beta
 21402
 0.19
chr16_59670319_59670470 0.06 ENSG00000200062
 .
 96364
 0.09
chr9_116394736_116394887 0.06 RGS3
 regulator of G-protein signaling 3
 39045
 0.17
chr3_187989157_187989308 0.06 LPP
 LIM domain containing preferred translocation partner in lipoma
 31580
 0.22
chr6_144007887_144008177 0.06 PHACTR2
 phosphatase and actin regulator 2
 8827
 0.27
chr1_51730316_51730746 0.06 RP11-296A18.6
1215
 0.4
chr12_52575126_52575277 0.06 KRT80
 keratin 80
 10583
 0.13
chr11_123460981_123461132 0.06 GRAMD1B
 GRAM domain containing 1B
 17461
 0.21
chr6_33580965_33581212 0.06 ITPR3
 inositol 1,4,5-trisphosphate receptor, type 3
 7054
 0.14
chr2_227624493_227624644 0.06 IRS1
 insulin receptor substrate 1
 39907
 0.16
chr3_49842732_49843503 0.06 ENSG00000263506
 .
 561
 0.55
chr11_2333873_2334024 0.06 ENSG00000207308
 .
 9000
 0.12
chr16_88703444_88703870 0.06 IL17C
 interleukin 17C
 1344
 0.26
chr3_123838707_123838915 0.06 ENSG00000266383
 .
 12965
 0.21
chr3_149325355_149325506 0.06 WWTR1
 WW domain containing transcription regulator 1
 31391
 0.15
chr9_112942282_112942517 0.06 C9orf152
 chromosome 9 open reading frame 152
 28070
 0.2
chr20_10963665_10963956 0.06 RP11-103J8.1
3513
 0.34
chr5_139069430_139069742 0.05 CXXC5
 CXXC finger protein 5
 10318
 0.2
chr10_126745390_126745757 0.05 ENSG00000264572
 .
 24134
 0.19
chr2_129063259_129063630 0.05 HS6ST1
 heparan sulfate 6-O-sulfotransferase 1
 12707
 0.24
chr6_19698381_19698532 0.05 ENSG00000200957
 .
 55696
 0.16
chr12_47025316_47025467 0.05 SLC38A4
 solute carrier family 38, member 4
 137696
 0.05
chr10_22723256_22723780 0.05 RP11-301N24.3
73417
 0.1
chr8_118826933_118827084 0.05 MED30
 mediator complex subunit 30
 293936
 0.01
chr2_133157691_133157842 0.05 ENSG00000252705
 .
 6665
 0.23
chr11_74037423_74037574 0.05 P4HA3
 prolyl 4-hydroxylase, alpha polypeptide III
 14796
 0.16
chr17_15224796_15224947 0.05 ENSG00000200437
 .
 10209
 0.17
chr3_154688977_154689233 0.05 MME
 membrane metallo-endopeptidase
 52808
 0.18
chr4_120573726_120573877 0.05 PDE5A
 phosphodiesterase 5A, cGMP-specific
 23655
 0.24
chr3_99129524_99129675 0.05 ENSG00000266030
 .
 43866
 0.2
chr8_99164226_99164377 0.05 POP1
 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
 34233
 0.13
chr11_70634178_70634329 0.05 SHANK2
 SH3 and multiple ankyrin repeat domains 2
 38392
 0.16
chr2_69449091_69449242 0.05 ENSG00000199460
 .
 39157
 0.15
chr6_122329509_122329660 0.05 ENSG00000199932
 .
 203210
 0.03
chr10_125689568_125689719 0.05 RP11-285A18.2
1470
 0.43
chr13_111059030_111059181 0.05 ENSG00000238629
 .
 7447
 0.24
chr7_90447196_90447347 0.05 CDK14
 cyclin-dependent kinase 14
 108095
 0.07
chrX_119003137_119003794 0.05 NDUFA1
 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
 1985
 0.21
chr8_123607926_123608077 0.05 ENSG00000238901
 .
 75529
 0.12
chr14_51974464_51974948 0.05 ENSG00000252400
 .
 14876
 0.21
chr3_55367534_55367685 0.05 WNT5A
 wingless-type MMTV integration site family, member 5A
 147615
 0.05
chr21_44922828_44923116 0.05 SIK1
 salt-inducible kinase 1
 75964
 0.1
chr2_216764593_216764988 0.05 ENSG00000212055
 .
 21148
 0.25
chr22_46402793_46403252 0.05 WNT7B
 wingless-type MMTV integration site family, member 7B
 30013
 0.1
chr2_46612633_46612855 0.05 ENSG00000241791
 .
 62906
 0.11
chr2_216613985_216614378 0.05 ENSG00000212055
 .
 129461
 0.05
chr14_94587792_94587943 0.05 IFI27L2
 interferon, alpha-inducible protein 27-like 2
 8134
 0.15
chr15_52935123_52935274 0.05 RP11-519C12.1
6865
 0.2
chr9_118294239_118294390 0.05 DEC1
 deleted in esophageal cancer 1
 390217
 0.01
chr6_158506907_158507345 0.05 SYNJ2
 synaptojanin 2
 8414
 0.21
chr9_130615331_130616090 0.05 ENG
 endoglin
 1205
 0.25
chr6_140075327_140075478 0.05 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
 379645
 0.01
chr18_11323846_11323997 0.05 PIEZO2
 piezo-type mechanosensitive ion channel component 2
 175334
 0.03
chr11_95555093_95555244 0.05 CEP57
 centrosomal protein 57kDa
 4167
 0.24
chr3_99964733_99964884 0.05 TBC1D23
 TBC1 domain family, member 23
 15036
 0.17
chr15_66938215_66938421 0.05 SMAD6
 SMAD family member 6
 56248
 0.1
chr1_183041587_183041738 0.05 LAMC1
 laminin, gamma 1 (formerly LAMB2)
 24017
 0.19
chr10_63553300_63553451 0.05 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 107684
 0.07
chr10_15336257_15336446 0.05 RP11-25G10.2
56860
 0.13
chr6_151151372_151151523 0.05 MTHFD1L
 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
 35238
 0.2
chr17_13496614_13496765 0.05 HS3ST3A1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
 8555
 0.26
chr7_134380957_134381211 0.05 BPGM
 2,3-bisphosphoglycerate mutase
 35911
 0.18
chr6_36216557_36216942 0.05 PNPLA1
 patatin-like phospholipase domain containing 1
 5769
 0.2
chr17_75251415_75251576 0.05 SEPT9
 septin 9
 25156
 0.19
chr11_69325521_69325672 0.05 CCND1
 cyclin D1
 130259
 0.05
chr6_85787065_85787216 0.05 TBX18
 T-box 18
 312903
 0.01
chr11_70228081_70228232 0.05 PPFIA1
 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
 3972
 0.15
chr11_130761204_130761355 0.05 SNX19
 sorting nexin 19
 2490
 0.42
chr3_66456383_66456534 0.05 ENSG00000241587
 .
 82179
 0.1
chr12_2394240_2394442 0.05 CACNA1C-IT3
 CACNA1C intronic transcript 3 (non-protein coding)
 15399
 0.25
chr9_98260446_98260655 0.05 RP11-435O5.6
3344
 0.21
chr1_21066214_21066365 0.05 RP5-930J4.4
3191
 0.17
chr20_45754813_45755050 0.05 ENSG00000264901
 .
 40678
 0.18
chr14_53301825_53302222 0.05 FERMT2
 fermitin family member 2
 29216
 0.15
chr9_74545305_74545456 0.05 C9orf85
 chromosome 9 open reading frame 85
 18803
 0.18
chr2_40327696_40327847 0.05 SLC8A1-AS1
 SLC8A1 antisense RNA 1
 4278
 0.36
chr5_171845939_171846090 0.05 ENSG00000216127
 .
 20744
 0.2
chr16_86696225_86696376 0.05 FOXL1
 forkhead box L1
 84185
 0.08
chr1_235097341_235097798 0.05 ENSG00000239690
 .
 57636
 0.14
chr1_113067186_113067337 0.05 RP4-671G15.2
6198
 0.2
chr7_94040475_94040626 0.05 COL1A2
 collagen, type I, alpha 2
 16677
 0.25
chr3_29724640_29724791 0.05 RBMS3-AS2
 RBMS3 antisense RNA 2
 40415
 0.22
chr7_72421339_72421490 0.05 NSUN5P2
 NOP2/Sun domain family, member 5 pseudogene 2
 3842
 0.13
chr5_39416035_39416186 0.05 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
 8860
 0.28
chr10_81896535_81896686 0.05 PLAC9
 placenta-specific 9
 4133
 0.22
chr10_97033802_97033953 0.05 PDLIM1
 PDZ and LIM domain 1
 16904
 0.21
chr6_2378075_2378226 0.05 ENSG00000266252
 .
 31719
 0.24
chr22_33104640_33104791 0.05 ENSG00000251890
 .
 73531
 0.1
chr19_19458792_19458943 0.05 MAU2
 MAU2 sister chromatid cohesion factor
 10852
 0.13
chr6_38315124_38315275 0.05 ENSG00000238716
 .
 11806
 0.28
chr8_70555415_70555566 0.05 ENSG00000222889
 .
 56969
 0.13
chr2_9450145_9450296 0.05 ASAP2
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
 103326
 0.06
chr2_134599157_134599414 0.05 ENSG00000200708
 .
 245623
 0.02
chr17_19233901_19234052 0.05 RP11-135L13.4
5464
 0.12
chr1_206687145_206687296 0.05 RASSF5
 Ras association (RalGDS/AF-6) domain family member 5
 6341
 0.15
chr4_189862800_189862951 0.05 ENSG00000252275
 .
 224996
 0.02
chr3_106329448_106329599 0.05 ENSG00000200361
 .
 78002
 0.11
chr17_59310548_59310699 0.05 RP11-136H19.1
97298
 0.07
chr8_6344138_6344289 0.05 ANGPT2
 angiopoietin 2
 76352
 0.1
chr22_31039864_31040015 0.05 SLC35E4
 solute carrier family 35, member E4
 7429
 0.13
chr11_10139098_10139249 0.05 RP11-748C4.1
31566
 0.21
chr2_33363115_33363266 0.05 LTBP1
 latent transforming growth factor beta binding protein 1
 3466
 0.36
chr16_73156371_73156706 0.05 C16orf47
 chromosome 16 open reading frame 47
 21808
 0.23
chr6_52392885_52393036 0.05 TRAM2
 translocation associated membrane protein 2
 48753
 0.15
chr2_190030887_190031038 0.05 COL5A2
 collagen, type V, alpha 2
 13643
 0.22
chr7_98438304_98438455 0.05 TMEM130
 transmembrane protein 130
 26190
 0.14
chr8_24206460_24207135 0.05 ADAM28
 ADAM metallopeptidase domain 28
 7632
 0.22
chr10_80838963_80839341 0.05 ZMIZ1
 zinc finger, MIZ-type containing 1
 10360
 0.24
chr1_223083321_223083472 0.05 ENSG00000239054
 .
 1893
 0.4
chr9_104277002_104277153 0.05 TMEM246
 transmembrane protein 246
 18653
 0.14
chr1_6803545_6803777 0.05 ENSG00000239166
 .
 9118
 0.17
chr10_31531410_31531796 0.05 ENSG00000252479
 .
 16925
 0.24
chr6_64516560_64517136 0.05 RP11-59D5__B.2
119
 0.98
chr16_49673318_49673469 0.05 ZNF423
 zinc finger protein 423
 1370
 0.54
chr1_221437708_221437859 0.05 HLX
 H2.0-like homeobox
 383199
 0.01
chr11_122068067_122068218 0.05 ENSG00000207994
 .
 45126
 0.13
chr11_113323627_113323778 0.05 ENSG00000265140
 .
 2892
 0.24
chr19_38490719_38490870 0.05 CTC-244M17.1
36301
 0.14
chr1_210536298_210536449 0.05 HHAT
 hedgehog acyltransferase
 177
 0.96
chr20_19795494_19795742 0.05 AL121761.2
 Uncharacterized protein
 56939
 0.12
chr2_106010411_106010562 0.05 FHL2
 four and a half LIM domains 2
 2756
 0.27
chr11_77654778_77654929 0.05 INTS4
 integrator complex subunit 4
 32653
 0.12
chr11_131729951_131730102 0.05 AP004372.1
36976
 0.19
chr1_159009390_159009541 0.05 ENSG00000265589
 .
 19574
 0.16
chr10_80713188_80713394 0.05 ZMIZ1-AS1
 ZMIZ1 antisense RNA 1
 8860
 0.31
chr1_856648_857113 0.05 SAMD11
 sterile alpha motif domain containing 11
 3380
 0.14
chr1_53914957_53915108 0.05 DMRTB1
 DMRT-like family B with proline-rich C-terminal, 1
 10040
 0.24
chr11_61772142_61772440 0.05 AP003733.1
 Uncharacterized protein; cDNA FLJ36460 fis, clone THYMU2014801
 36838
 0.11
chr15_63142711_63142998 0.05 RP11-1069G10.1
6074
 0.22
chr2_28884288_28884439 0.05 AC074011.2
3043
 0.24
chr2_10119571_10119722 0.05 GRHL1
 grainyhead-like 1 (Drosophila)
 15788
 0.16
chr6_126135548_126136266 0.05 NCOA7
 nuclear receptor coactivator 7
 457
 0.81
chr18_48596659_48596948 0.05 SMAD4
 SMAD family member 4
 3320
 0.29
chr9_111815301_111815452 0.05 ENSG00000207698
 .
 6798
 0.16
chr14_55603634_55603785 0.05 LGALS3
 lectin, galactoside-binding, soluble, 3
 7731
 0.23
chr16_64447214_64447365 0.05 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 646292
 0.0
chr9_16031542_16031875 0.05 C9orf92
 chromosome 9 open reading frame 92
 184189
 0.03
chr6_38314206_38314357 0.05 ENSG00000238716
 .
 12724
 0.28
chr7_75043431_75043582 0.05 NSUN5P1
 NOP2/Sun domain family, member 5 pseudogene 1
 1676
 0.23
chr19_42781870_42782547 0.05 CIC
 capicua transcriptional repressor
 5964
 0.09
chr6_113468381_113468532 0.05 ENSG00000201386
 .
 175761
 0.03
chr14_71710075_71710226 0.05 AC004817.1
 HCG2028611; Uncharacterized protein
 26688
 0.21

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.0 GO:0035583 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.0 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.0 GO:0045630 positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0 0.0 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0004103 choline kinase activity(GO:0004103)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling