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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for TCF21
Z-value: 1.59
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Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:
This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.
For each TF, only the top 5 correlated CREs are shown.
| CRE | Gene | Distance | Association probability | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|---|---|
| chr6_134210511_134210662 | TCF21 | 113 | 0.841016 | 0.37 | 3.3e-01 | Click! |
| chr6_134210875_134211079 | TCF21 | 504 | 0.634825 | 0.23 | 5.4e-01 | Click! |
Showing 1 to 2 of 2 entries
Top target CREs of the motif:
| Cis Regulatory Element (CRE) | Target Score | Top associated gene | Gene Info | Distance of CRE to TSS | CRE/Gene association probability |
|---|---|---|---|---|---|
| chr7_37355725_37356299 | 1.16 |
ELMO1 |
engulfment and cell motility 1 |
26355 |
0.19 |
| chr12_122327188_122327339 | 0.86 |
PSMD9 |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 |
571 |
0.69 |
| chr17_3865194_3865538 | 0.70 |
ATP2A3 |
ATPase, Ca++ transporting, ubiquitous |
2219 |
0.29 |
| chr2_198127644_198128365 | 0.66 |
ANKRD44-IT1 |
ANKRD44 intronic transcript 1 (non-protein coding) |
39239 |
0.13 |
| chr3_13459505_13459764 | 0.65 |
NUP210 |
nucleoporin 210kDa |
2175 |
0.38 |
| chr6_130040950_130041101 | 0.61 |
ARHGAP18 |
Rho GTPase activating protein 18 |
9655 |
0.25 |
| chr13_51465573_51465808 | 0.59 |
RNASEH2B-AS1 |
RNASEH2B antisense RNA 1 |
88 |
0.97 |
| chr19_16228666_16229162 | 0.59 |
RAB8A |
RAB8A, member RAS oncogene family |
6207 |
0.14 |
| chr1_169659354_169659683 | 0.59 |
SELL |
selectin L |
21321 |
0.18 |
| chr2_99068894_99069462 | 0.59 |
INPP4A |
inositol polyphosphate-4-phosphatase, type I, 107kDa |
7765 |
0.25 |
Histogram of CRE-TSS distances for CREs targeted by :
Rank distribution of CRE target scores:
Distribution of target CREs across different genomic regions:
Network of associatons between targets according to the STRING database.
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.0 | 1.2 | GO:0050772 | positive regulation of axonogenesis(GO:0050772) |
| 0.2 | 0.9 | GO:0045589 | regulation of regulatory T cell differentiation(GO:0045589) |
| 0.1 | 0.8 | GO:0032753 | positive regulation of interleukin-4 production(GO:0032753) |
| 0.0 | 0.8 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.0 | 0.8 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.2 | 0.7 | GO:0032237 | activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341) |
| 0.1 | 0.7 | GO:0006032 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.0 | 0.7 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.2 | 0.6 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.9 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.0 | 0.8 | GO:0016605 | PML body(GO:0016605) |
| 0.2 | 0.6 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.2 | 0.6 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.0 | 0.6 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 0.6 | GO:0070603 | SWI/SNF superfamily-type complex(GO:0070603) |
| 0.0 | 0.6 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 0.6 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 0.5 | GO:0001772 | immunological synapse(GO:0001772) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.0 | 1.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 1.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 1.0 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 1.0 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 0.8 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 0.8 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.1 | 0.7 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 0.7 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.6 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 1.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.5 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 1.2 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.1 | 1.1 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 1.1 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 0.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 0.5 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.5 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 1.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 1.3 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 1.3 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 1.2 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.2 | REACTOME SIGNALING BY SCF KIT | Genes involved in Signaling by SCF-KIT |
| 0.0 | 1.1 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.1 | 1.0 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 1.0 | REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS | Genes involved in Activation of NMDA receptor upon glutamate binding and postsynaptic events |