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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for TFAP2E

Z-value: 1.13

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Transcription factors associated with TFAP2E

Gene Symbol	Gene ID	Gene Info
TFAP2E Ensembl NCBI GeneCards UniProt	ENSG00000116819.6	TFAP2E

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
TFAP2E	chr1_36034994_36035145	3902	0.163329	0.87	2.2e-03	Click!
TFAP2E	chr1_36035927_36036078	2969	0.182736	0.70	3.5e-02	Click!
TFAP2E	chr1_36038348_36038499	548	0.566719	0.37	3.2e-01	Click!
TFAP2E	chr1_36035265_36035416	3631	0.167671	0.37	3.3e-01	Click!
TFAP2E	chr1_36038695_36039018	115	0.844928	0.03	9.3e-01	Click!

Activity of the TFAP2E motif across conditions

Conditions sorted by the z-value of the TFAP2E motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_127489904_127490214	0.80	MGLL	monoglyceride lipase	12792	0.24
chr7_155377735_155377886	0.64	CNPY1	canopy FGF signaling regulator 1	51253	0.12
chr10_18071932_18072083	0.63	MRC1	mannose receptor, C type 1	26345	0.17
chr2_238783166_238783317	0.57	ENSG00000263723	.	4694	0.22
chr20_16507696_16507995	0.55	KIF16B	kinesin family member 16B	46233	0.18
chr8_96237601_96237983	0.54	C8orf37	chromosome 8 open reading frame 37	43637	0.17
chr20_33166706_33166857	0.53	MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	20259	0.16
chr10_96974401_96974606	0.53	RP11-310E22.4		16398	0.21
chr10_104539691_104539842	0.52	WBP1L	WW domain binding protein 1-like	3760	0.18
chr2_69034764_69034964	0.50	ARHGAP25	Rho GTPase activating protein 25	501	0.82
chr8_8269357_8269508	0.49	SGK223	Tyrosine-protein kinase SgK223	25424	0.23
chr15_85215324_85215475	0.49	NMB	neuromedin B	13605	0.1
chr2_9815348_9815499	0.48	YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta	44280	0.14
chr9_136741627_136741778	0.47	VAV2	vav 2 guanine nucleotide exchange factor	115701	0.05
chr12_122519590_122520270	0.47	MLXIP	MLX interacting protein	3302	0.29
chr17_27910417_27910568	0.46	GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	398	0.68
chr15_44205800_44205951	0.46	FRMD5	FERM domain containing 5	5825	0.19
chr4_5638816_5638967	0.45	EVC2	Ellis van Creveld syndrome 2	71403	0.11
chr5_92629860_92630011	0.45	ENSG00000237187	.	128184	0.06
chr2_40662476_40662683	0.45	SLC8A1	solute carrier family 8 (sodium/calcium exchanger), member 1	5135	0.35
chr2_153406171_153406322	0.44	FMNL2	formin-like 2	69846	0.13
chr1_118644337_118644488	0.43	SPAG17	sperm associated antigen 17	83434	0.1
chr2_102680238_102680787	0.43	IL1R1	interleukin 1 receptor, type I	492	0.85
chr8_143762185_143762336	0.42	PSCA	prostate stem cell antigen	385	0.77
chr15_72487652_72487940	0.42	GRAMD2	GRAM domain containing 2	2330	0.25
chr14_65703391_65703542	0.41	ENSG00000266740	.	98435	0.07
chr5_81661345_81661496	0.40	ATP6AP1L	ATPase, H+ transporting, lysosomal accessory protein 1-like	60254	0.15
chr19_8053652_8053803	0.39	ELAVL1	ELAV like RNA binding protein 1	7731	0.11
chr12_32242647_32242798	0.39	BICD1	bicaudal D homolog 1 (Drosophila)	17047	0.21
chr8_124468816_124468967	0.39	WDYHV1	WDYHV motif containing 1	26656	0.16
chr7_155049692_155049843	0.39	INSIG1	insulin induced gene 1	39719	0.15
chr2_112255788_112255939	0.39	ENSG00000266139	.	177195	0.03
chr5_110789980_110790131	0.39	STARD4-AS1	STARD4 antisense RNA 1	57869	0.12
chr1_110598662_110598813	0.39	RP4-773N10.4		2225	0.21
chr17_47786040_47786409	0.38	SLC35B1	solute carrier family 35, member B1	152	0.82
chr16_70414605_70414756	0.38	RP11-529K1.4		1320	0.31
chr3_54925868_54926132	0.37	CACNA2D3-AS1	CACNA2D3 antisense RNA 1	9282	0.27
chr7_137564480_137564636	0.37	DGKI	diacylglycerol kinase, iota	32720	0.18
chr11_27444813_27444964	0.37	RP11-159H22.2		48388	0.12
chr6_11212735_11212977	0.36	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	20035	0.2
chr15_67316146_67316685	0.36	SMAD3	SMAD family member 3	39686	0.2
chr1_211665583_211665734	0.35	RD3	retinal degeneration 3	601	0.8
chr12_112550183_112550334	0.35	NAA25	N(alpha)-acetyltransferase 25, NatB auxiliary subunit	3432	0.18
chr19_14669270_14669558	0.35	TECR	trans-2,3-enoyl-CoA reductase	3365	0.13
chr22_38531557_38531708	0.35	PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)	2748	0.19
chr19_4712858_4713009	0.35	DPP9	dipeptidyl-peptidase 9	1385	0.3
chr5_167243493_167243835	0.34	ENSG00000221741	.	54006	0.13
chr2_216783049_216783200	0.34	ENSG00000212055	.	39482	0.19
chr12_3231998_3232272	0.34	TSPAN9-IT1	TSPAN9 intronic transcript 1 (non-protein coding)	26828	0.19
chr4_185739235_185739386	0.33	RP11-701P16.2	Uncharacterized protein	4537	0.2
chr1_179096650_179096926	0.33	ABL2	c-abl oncogene 2, non-receptor tyrosine kinase	15391	0.19
chr11_111794694_111794845	0.33	CRYAB	crystallin, alpha B	323	0.78
chr15_31898343_31898494	0.33	OTUD7A	OTU domain containing 7A	49124	0.19
chr10_79152930_79153197	0.33	KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	10679	0.24
chr1_17519325_17519476	0.33	PADI1	peptidyl arginine deiminase, type I	12221	0.17
chr4_55529764_55530043	0.33	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	5818	0.34
chr2_20777848_20777999	0.33	HS1BP3-IT1	HS1BP3 intronic transcript 1 (non-protein coding)	14385	0.21
chr4_142273560_142273938	0.33	ENSG00000238695	.	54717	0.16
chr4_78783004_78783324	0.32	MRPL1	mitochondrial ribosomal protein L1	510	0.86
chr5_148349011_148349162	0.32	RP11-44B19.1		817	0.67
chr10_116154509_116154660	0.32	AFAP1L2	actin filament associated protein 1-like 2	9655	0.23
chr2_164538752_164538903	0.32	FIGN	fidgetin	53690	0.19
chr5_9048002_9048358	0.32	ENSG00000266415	.	5827	0.3
chrX_14977641_14977792	0.31	MOSPD2	motile sperm domain containing 2	50672	0.17
chr17_70461708_70461859	0.31	ENSG00000200783	.	198508	0.03
chr11_124770110_124770261	0.31	ROBO4	roundabout, axon guidance receptor, homolog 4 (Drosophila)	2008	0.19
chr1_161171729_161171880	0.31	NDUFS2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	133	0.88
chr2_159779762_159779913	0.31	ENSG00000222300	.	12660	0.2
chr1_239620290_239620441	0.31	CHRM3	cholinergic receptor, muscarinic 3	172008	0.04
chr1_115782386_115782537	0.31	RP4-663N10.1		43194	0.18
chr17_34112154_34112305	0.30	MMP28	matrix metallopeptidase 28	5857	0.11
chr18_20862079_20862230	0.30	RP11-17J14.2		21836	0.23
chr1_213293309_213293460	0.30	RPS6KC1	ribosomal protein S6 kinase, 52kDa, polypeptide 1	68780	0.12
chrX_118628293_118628444	0.30	SLC25A5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5	26005	0.12
chr3_149290093_149290244	0.30	WWTR1	WW domain containing transcription regulator 1	3871	0.25
chr19_13171036_13171187	0.30	AC007787.2		11077	0.1
chr16_75282266_75282417	0.30	BCAR1	breast cancer anti-estrogen resistance 1	203	0.92
chr20_39122912_39123063	0.30	ENSG00000252434	.	77472	0.12
chr6_14716899_14717050	0.30	ENSG00000206960	.	70208	0.14
chr8_126668851_126669002	0.30	ENSG00000266452	.	212119	0.02
chr1_24691365_24691516	0.29	STPG1	sperm-tail PG-rich repeat containing 1	14873	0.16
chr11_78494593_78494744	0.29	TENM4	teneurin transmembrane protein 4	21788	0.22
chr1_161052827_161053090	0.29	RP11-544M22.8		1297	0.22
chr11_119189693_119189895	0.29	MCAM	melanoma cell adhesion molecule	1968	0.16
chr1_45990852_45991003	0.29	PRDX1	peroxiredoxin 1	2208	0.22
chr6_140783983_140784266	0.29	ENSG00000221336	.	197726	0.03
chr8_41009602_41009753	0.29	ENSG00000263372	.	118985	0.05
chr10_112158236_112158389	0.29	ENSG00000221359	.	35687	0.17
chr12_120667456_120667944	0.29	PXN	paxillin	3053	0.16
chr5_77881787_77882057	0.29	LHFPL2	lipoma HMGIC fusion partner-like 2	36948	0.23
chr17_58218497_58218710	0.29	CA4	carbonic anhydrase IV	8694	0.18
chr1_41356534_41356685	0.28	RP5-1066H13.4		27023	0.15
chr11_7913917_7914068	0.28	ENSG00000252769	.	3166	0.19
chr3_183740027_183740178	0.28	ABCC5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	4299	0.14
chr11_47560816_47560967	0.28	CELF1	CUGBP, Elav-like family member 1	13778	0.08
chr6_100677123_100677274	0.28	RP1-121G13.2		197796	0.03
chr2_171829322_171830003	0.28	GORASP2	golgi reassembly stacking protein 2, 55kDa	43831	0.15
chr2_65214115_65214266	0.28	SLC1A4	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	1434	0.38
chr2_110087186_110087362	0.28	ENSG00000265965	.	157193	0.04
chr9_75169117_75169268	0.28	ENSG00000238402	.	27040	0.21
chr2_48646919_48647208	0.28	PPP1R21	protein phosphatase 1, regulatory subunit 21	20845	0.21
chr10_25348795_25348946	0.28	ENSG00000266069	.	31613	0.16
chr11_44586009_44586190	0.28	CD82	CD82 molecule	122	0.97
chr1_20930163_20930437	0.28	CDA	cytidine deaminase	14859	0.16
chr4_38103387_38103538	0.27	TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	55970	0.16
chr1_172446166_172446317	0.27	C1orf105	chromosome 1 open reading frame 105	24208	0.17
chr10_126029743_126029894	0.27	OAT	ornithine aminotransferase	77687	0.1
chr15_62910288_62910439	0.27	RP11-625H11.1	Uncharacterized protein	27017	0.18
chr10_73620641_73620884	0.27	PSAP	prosaposin	9636	0.2
chr16_73098361_73099003	0.27	ZFHX3	zinc finger homeobox 3	5085	0.26
chr17_19215367_19215621	0.27	EPN2-AS1	EPN2 antisense RNA 1	5920	0.12
chr15_101652404_101652555	0.27	RP11-505E24.2		26208	0.2
chr8_81665342_81665642	0.26	ENSG00000212429	.	3564	0.28
chr1_62146544_62146695	0.26	TM2D1	TM2 domain containing 1	44186	0.15
chr20_2795102_2795253	0.26	TMEM239	CDNA FLJ26142 fis, clone TST04526; Transmembrane protein 239; Uncharacterized protein	437	0.45
chr1_53977593_53977891	0.26	DMRTB1	DMRT-like family B with proline-rich C-terminal, 1	52670	0.14
chr8_96111972_96112794	0.26	RP11-320N21.2		12231	0.16
chr1_22623912_22624063	0.26	ENSG00000266564	.	31255	0.21
chr12_45829168_45829319	0.26	ENSG00000239178	.	119199	0.06
chr10_126805401_126805552	0.26	CTBP2	C-terminal binding protein 2	41809	0.18
chr1_167127568_167127862	0.26	RP11-277B15.2		37002	0.13
chr5_122765001_122765271	0.26	CEP120	centrosomal protein 120kDa	5850	0.29
chr7_150097245_150097396	0.25	RP4-584D14.6		16347	0.11
chr12_132347924_132348141	0.25	MMP17	matrix metallopeptidase 17 (membrane-inserted)	18192	0.15
chr9_129110024_129110380	0.25	MVB12B	multivesicular body subunit 12B	12676	0.24
chr7_102515337_102515656	0.25	ENSG00000238324	.	17599	0.16
chr22_36720785_36721049	0.25	ENSG00000266345	.	8671	0.19
chr2_26981199_26981390	0.25	SLC35F6	solute carrier family 35, member F6	5862	0.19
chr6_125203361_125203883	0.25	RNF217	ring finger protein 217	80069	0.11
chr16_67742664_67742903	0.25	GFOD2	glucose-fructose oxidoreductase domain containing 2	10541	0.11
chr16_68986638_68986789	0.25	RP11-521L9.2		18990	0.18
chr3_128267799_128268165	0.25	C3orf27	chromosome 3 open reading frame 27	26947	0.16
chrX_45182411_45182562	0.25	RP11-342D14.1		2783	0.41
chr1_32049799_32049950	0.25	TINAGL1	tubulointerstitial nephritis antigen-like 1	7735	0.14
chr19_42900464_42900801	0.25	LIPE-AS1	LIPE antisense RNA 1	648	0.56
chr7_76057799_76057950	0.25	ZP3	zona pellucida glycoprotein 3 (sperm receptor)	81	0.96
chr10_116072655_116072806	0.25	VWA2	von Willebrand factor A domain containing 2	73641	0.09
chr20_48310267_48310418	0.25	B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	20073	0.18
chr2_201622113_201622264	0.25	ENSG00000201737	.	18119	0.14
chr17_32698121_32698371	0.24	CCL1	chemokine (C-C motif) ligand 1	7996	0.18
chr4_5637335_5637511	0.24	EVC2	Ellis van Creveld syndrome 2	72871	0.1
chr5_81701965_81702116	0.24	ATP6AP1L	ATPase, H+ transporting, lysosomal accessory protein 1-like	100874	0.08
chr2_145082101_145082252	0.24	GTDC1	glycosyltransferase-like domain containing 1	4739	0.34
chr7_127661423_127661614	0.24	LRRC4	leucine rich repeat containing 4	9540	0.25
chr8_37468333_37468484	0.24	ENSG00000223215	.	58008	0.1
chr14_23316976_23317711	0.24	ENSG00000212335	.	4594	0.09
chr1_184591672_184591823	0.24	ENSG00000252790	.	55321	0.15
chr17_66449042_66449331	0.24	WIPI1	WD repeat domain, phosphoinositide interacting 1	4376	0.23
chr13_33804052_33804203	0.23	STARD13	StAR-related lipid transfer (START) domain containing 13	23984	0.2
chr20_30199424_30199575	0.23	ENSG00000264395	.	4510	0.13
chrX_22153582_22153733	0.23	PHEX-AS1	PHEX antisense RNA 1	37443	0.16
chr14_59219843_59220151	0.23	ENSG00000221427	.	17967	0.27
chr15_74274351_74275014	0.23	STOML1	stomatin (EPB72)-like 1	9493	0.15
chr13_32708450_32708601	0.23	FRY	furry homolog (Drosophila)	73524	0.11
chr13_49671478_49671629	0.23	ENSG00000199788	.	2026	0.36
chr2_28660054_28660205	0.23	PLB1	phospholipase B1	19883	0.17
chr8_26498187_26498401	0.23	DPYSL2	dihydropyrimidinase-like 2	62373	0.14
chr5_125808253_125808404	0.23	RP11-517I3.1		5005	0.23
chr2_33352313_33352464	0.23	LTBP1	latent transforming growth factor beta binding protein 1	7085	0.3
chr19_39853657_39853808	0.22	ENSG00000241983	.	6061	0.09
chr22_35907056_35907207	0.22	RASD2	RASD family, member 2	29784	0.19
chr18_21795564_21795715	0.22	ENSG00000206766	.	2625	0.23
chr6_167142675_167142845	0.22	RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	28639	0.23
chr4_139531486_139531637	0.22	ENSG00000238971	.	201359	0.03
chr5_139721285_139721505	0.22	HBEGF	heparin-binding EGF-like growth factor	4793	0.14
chr3_69439182_69439463	0.22	FRMD4B	FERM domain containing 4B	3892	0.36
chr1_223308438_223308608	0.22	TLR5	toll-like receptor 5	425	0.91
chr1_230850007_230850201	0.22	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	61	0.97
chr15_91285398_91285560	0.22	ENSG00000200677	.	13063	0.14
chr5_139621230_139621381	0.22	CTB-131B5.2		41557	0.1
chr14_72180385_72180536	0.22	SIPA1L1	signal-induced proliferation-associated 1 like 1	94987	0.09
chr8_37376201_37376352	0.22	RP11-150O12.6		1737	0.48
chr3_151893804_151894059	0.22	MBNL1	muscleblind-like splicing regulator 1	91898	0.08
chr7_134893432_134893608	0.22	WDR91	WD repeat domain 91	2131	0.24
chr1_144085227_144085501	0.22	NBPF8	neuroblastoma breakpoint family, member 8	61444	0.14
chr6_140784427_140784578	0.22	ENSG00000221336	.	197348	0.03
chr2_85933045_85933196	0.22	GNLY	granulysin	10629	0.13
chr22_46498265_46498416	0.22	ENSG00000198986	.	10289	0.1
chr3_15672619_15672770	0.22	BTD	biotinidase	29218	0.14
chr1_1295387_1295783	0.22	MXRA8	matrix-remodelling associated 8	1572	0.16
chr15_35330956_35331107	0.22	ZNF770	zinc finger protein 770	50543	0.14
chr22_46485560_46485711	0.22	ENSG00000266533	.	1289	0.27
chr14_63904786_63905352	0.22	ENSG00000264995	.	24655	0.16
chr1_42641010_42641161	0.22	GUCA2A	guanylate cyclase activator 2A (guanylin)	10696	0.19
chr13_80657315_80657466	0.22	SPRY2	sprouty homolog 2 (Drosophila)	256404	0.02
chr5_142280838_142280989	0.22	ARHGAP26	Rho GTPase activating protein 26	5974	0.27
chr2_241860537_241860698	0.21	AC104809.3	Protein LOC728763	1369	0.36
chr10_95136688_95136839	0.21	MYOF	myoferlin	105188	0.06
chr8_85095605_85095756	0.21	RALYL	RALY RNA binding protein-like	89	0.99
chr22_46487788_46487939	0.21	ENSG00000266533	.	939	0.38
chr2_19015414_19015565	0.21	NT5C1B	5'-nucleotidase, cytosolic IB	244651	0.02
chr10_128777765_128777916	0.21	RP11-223P11.3		46846	0.16
chr17_36433052_36433525	0.21	RP11-1407O15.2	TBC1 domain family member 3	11447	0.15
chr3_138187920_138188071	0.21	CEP70	centrosomal protein 70kDa	31027	0.18
chr1_215843470_215843621	0.21	ENSG00000202498	.	40086	0.2
chr11_45067696_45067847	0.21	PRDM11	PR domain containing 11	47793	0.17
chr9_133323468_133323619	0.21	ENSG00000238298	.	1698	0.3
chr12_57611386_57611537	0.21	NXPH4	neurexophilin 4	883	0.39
chrX_69394860_69395105	0.21	DGAT2L6	diacylglycerol O-acyltransferase 2-like 6	2351	0.2
chr9_139492984_139493135	0.21	ENSG00000252440	.	3908	0.13

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2E

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0071731	response to nitric oxide(GO:0071731)
0.1	0.2	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.1	0.2	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.1	0.2	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.1	0.2	GO:0052305	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.1	0.2	GO:0071436	sodium ion export(GO:0071436)
0.1	0.2	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.0	0.1	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0032328	alanine transport(GO:0032328)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0048670	regulation of collateral sprouting(GO:0048670)
0.0	0.1	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.2	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.2	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.1	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.1	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.1	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.1	GO:0051834	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0002686	negative regulation of leukocyte migration(GO:0002686)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.2	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:1903672	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.0	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	0.1	GO:0046471	phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0	0.1	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.2	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.1	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.0	GO:1903579	negative regulation of nucleoside metabolic process(GO:0045978) negative regulation of ATP metabolic process(GO:1903579)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.0	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.0	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0	0.0	GO:0090103	cochlea morphogenesis(GO:0090103)
0.0	0.1	GO:0031122	cytoplasmic microtubule organization(GO:0031122)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0042249	establishment of planar polarity of embryonic epithelium(GO:0042249)
0.0	0.1	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.0	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.1	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.0	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.0	GO:0032353	negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0	0.1	GO:0060897	neural plate anterior/posterior regionalization(GO:0021999) neural plate regionalization(GO:0060897)
0.0	0.0	GO:0071294	cellular response to zinc ion(GO:0071294)
0.0	0.1	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0	0.1	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.1	GO:0015884	folic acid transport(GO:0015884)
0.0	0.1	GO:0032495	response to muramyl dipeptide(GO:0032495)
0.0	0.1	GO:0032055	negative regulation of translation in response to stress(GO:0032055)
0.0	0.1	GO:0032226	positive regulation of synaptic transmission, dopaminergic(GO:0032226)
0.0	0.1	GO:0006991	response to sterol depletion(GO:0006991)
0.0	0.1	GO:0022011	myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0	0.1	GO:0009188	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.0	GO:0033145	positive regulation of intracellular steroid hormone receptor signaling pathway(GO:0033145)
0.0	0.1	GO:0046541	saliva secretion(GO:0046541)
0.0	0.0	GO:0048714	positive regulation of oligodendrocyte differentiation(GO:0048714)
0.0	0.1	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.0	0.0	GO:0015853	adenine transport(GO:0015853)
0.0	0.0	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.0	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.0	0.1	GO:0014911	positive regulation of smooth muscle cell migration(GO:0014911)
0.0	0.0	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.0	GO:0048808	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0	0.0	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.0	GO:0048245	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.0	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.0	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.1	GO:0031062	positive regulation of histone methylation(GO:0031062)
0.0	0.0	GO:0050932	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.0	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.1	GO:0040023	establishment of nucleus localization(GO:0040023)
0.0	0.1	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.0	GO:0060052	neurofilament cytoskeleton organization(GO:0060052)
0.0	0.2	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.0	GO:0048539	bone marrow development(GO:0048539)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0002080	acrosomal membrane(GO:0002080)
0.2	GO:0060199	clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.2	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	GO:0033646	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.2	GO:0002102	podosome(GO:0002102)
0.1	GO:0042583	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.2	GO:0030315	T-tubule(GO:0030315)
0.3	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.1	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	GO:0031904	endosome lumen(GO:0031904)
0.0	GO:0070852	cell body fiber(GO:0070852)
0.1	GO:0001527	microfibril(GO:0001527)
0.1	GO:0000800	lateral element(GO:0000800)
0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2	GO:0000421	autophagosome membrane(GO:0000421)
0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.1	GO:0071817	MMXD complex(GO:0071817)
0.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	GO:0043259	laminin-10 complex(GO:0043259)
0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.1	GO:0043034	costamere(GO:0043034)
0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
1.0	GO:0005925	focal adhesion(GO:0005925)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.2	GO:0032190	acrosin binding(GO:0032190)
0.1	0.4	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.2	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.2	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.3	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:1901474	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.2	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.2	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.3	GO:0048038	quinone binding(GO:0048038)
0.0	0.1	GO:0008079	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0008172	S-methyltransferase activity(GO:0008172)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.1	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.1	GO:0005497	androgen binding(GO:0005497)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.3	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.0	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.0	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.0	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.0	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.2	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.1	GO:0004457	lactate dehydrogenase activity(GO:0004457)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.3	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.0	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0032041	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.0	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.5	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.4	PID IL1 PATHWAY	IL1-mediated signaling events
0.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.4	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway