CREMA results: TFCP2L1

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Transcription factors associated with TFCP2L1

Gene Symbol	Gene ID	Gene Info
TFCP2L1 Ensembl NCBI GeneCards UniProt	ENSG00000115112.7	transcription factor CP2 like 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr2_121943079_121943230	TFCP2L1	99629	0.077986	0.75	2.1e-02	Click!
chr2_121943870_121944021	TFCP2L1	98838	0.078951	0.73	2.5e-02	Click!
chr2_121955015_121955166	TFCP2L1	87693	0.094284	0.84	4.5e-03	Click!
chr2_121955307_121955495	TFCP2L1	87382	0.094758	0.86	3.2e-03	Click!
chr2_122042236_122042419	TFCP2L1	456	0.895965	0.72	3.0e-02	Click!

Showing 1 to 5 of 5 entries

Activity of the TFCP2L1 motif across conditions

Conditions sorted by the z-value of the TFCP2L1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_2143838_2144020	0.90	ENSG00000207805	.	11510	0.11
chr9_37998704_37998932	0.71	ENSG00000251745	.	62053	0.11
chr5_179192932_179193104	0.67	LTC4S	leukotriene C4 synthase	27969	0.09
chr16_85269698_85270157	0.66	CTC-786C10.1		65045	0.11
chr18_20882637_20882788	0.63	RP11-17J14.2		42394	0.17
chr1_155223556_155224415	0.63	FAM189B	family with sequence similarity 189, member B	714	0.38
chr10_133760189_133760615	0.56	PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	6869	0.26
chr20_43335077_43335228	0.56	WISP2	WNT1 inducible signaling pathway protein 2	8333	0.13
chr1_110599846_110600005	0.55	RP4-773N10.4		1037	0.42
chr12_52540643_52541115	0.54	ENSG00000265804	.	33170	0.09

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TFCP2L1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	GO:0030199	collagen fibril organization(GO:0030199)
0.1	0.4	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.1	0.4	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.4	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.4	GO:0035329	hippo signaling(GO:0035329)
0.1	0.3	GO:0010193	response to ozone(GO:0010193)
0.1	0.3	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.1	0.3	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.1	0.3	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.1	0.3	GO:0007028	cytoplasm organization(GO:0007028)

Showing 1 to 10 of 229 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0030496	midbody(GO:0030496)
0.1	0.4	GO:0001527	microfibril(GO:0001527)
0.0	0.4	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1	0.3	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.3	GO:0070822	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0	0.3	GO:0005811	lipid particle(GO:0005811)
0.0	0.3	GO:0001533	cornified envelope(GO:0001533)
0.0	0.2	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.2	GO:0031045	dense core granule(GO:0031045)
0.0	0.2	GO:0031083	BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)

Showing 1 to 10 of 69 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	0.5	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.4	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.4	GO:0017166	vinculin binding(GO:0017166)
0.0	0.4	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.4	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.1	0.3	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.3	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.3	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.3	GO:0005112	Notch binding(GO:0005112)

Showing 1 to 10 of 166 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.9	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.7	NABA COLLAGENS	Genes encoding collagen proteins
0.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.5	PID RAS PATHWAY	Regulation of Ras family activation
0.4	PID AURORA A PATHWAY	Aurora A signaling
0.3	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Showing 1 to 10 of 24 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.8	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.4	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.3	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.3	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism

Showing 1 to 10 of 43 entries

Results for TFCP2L1

Z-value: 1.36

Motif logo

Transcription factors associated with TFCP2L1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the TFCP2L1 motif across conditions

Conditions sorted by the z-value of the TFCP2L1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TFCP2L1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: