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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for TFEC_MITF_ARNTL_BHLHE41

Z-value: 0.83

Motif logo

Transcription factors associated with TFEC_MITF_ARNTL_BHLHE41

Gene Symbol	Gene ID	Gene Info
TFEC Ensembl NCBI GeneCards UniProt	ENSG00000105967.11	TFEC
MITF Ensembl NCBI GeneCards UniProt	ENSG00000187098.10	MITF
ARNTL Ensembl NCBI GeneCards UniProt	ENSG00000133794.13	ARNTL
BHLHE41 Ensembl NCBI GeneCards UniProt	ENSG00000123095.5	BHLHE41

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ARNTL	chr11_13230039_13230195	68082	0.127970	0.86	3.1e-03	Click!
ARNTL	chr11_13312870_13313021	13513	0.259982	-0.83	5.8e-03	Click!
ARNTL	chr11_13229796_13230015	68294	0.127528	0.78	1.3e-02	Click!
ARNTL	chr11_13282555_13282706	15569	0.269293	0.75	2.1e-02	Click!
ARNTL	chr11_13314702_13314853	15345	0.254012	-0.73	2.5e-02	Click!
BHLHE41	chr12_26277295_26278057	384	0.777876	-0.66	5.3e-02	Click!
BHLHE41	chr12_26278311_26278658	424	0.539953	0.03	9.3e-01	Click!
MITF	chr3_69789658_69789810	1112	0.607008	0.80	1.0e-02	Click!
MITF	chr3_69813958_69814283	1158	0.558041	0.73	2.6e-02	Click!
MITF	chr3_69813399_69813761	618	0.782625	0.70	3.4e-02	Click!
MITF	chr3_69810828_69810979	972	0.633922	0.69	4.0e-02	Click!
MITF	chr3_69788296_69788550	163	0.969196	-0.64	6.5e-02	Click!
TFEC	chr7_115556505_115556656	51724	0.167210	-0.63	7.2e-02	Click!
TFEC	chr7_115662328_115662479	8392	0.309240	-0.61	8.1e-02	Click!
TFEC	chr7_115803556_115803707	3681	0.298289	0.60	8.5e-02	Click!
TFEC	chr7_115808920_115809071	9045	0.241313	0.60	8.9e-02	Click!
TFEC	chr7_115785682_115785833	14193	0.249470	0.58	1.0e-01	Click!

Activity of the TFEC_MITF_ARNTL_BHLHE41 motif across conditions

Conditions sorted by the z-value of the TFEC_MITF_ARNTL_BHLHE41 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_114280008_114280159	0.83	ATP4B	ATPase, H+/K+ exchanging, beta polypeptide	32418	0.15
chr13_114280229_114280380	0.59	ATP4B	ATPase, H+/K+ exchanging, beta polypeptide	32197	0.15
chr16_85549609_85549893	0.45	ENSG00000264203	.	74653	0.09
chr13_44730147_44730391	0.43	SMIM2-IT1	SMIM2 intronic transcript 1 (non-protein coding)	2089	0.32
chr6_16681395_16681795	0.41	RP1-151F17.1		79774	0.1
chr3_125322024_125322175	0.41	OSBPL11	oxysterol binding protein-like 11	8165	0.22
chr5_343224_343631	0.41	AHRR	aryl-hydrocarbon receptor repressor	216	0.94
chr10_81160624_81160775	0.38	RP11-342M3.5		18615	0.19
chr2_235866357_235866729	0.36	SH3BP4	SH3-domain binding protein 4	5823	0.35
chr2_40266109_40266315	0.34	SLC8A1-AS1	SLC8A1 antisense RNA 1	3278	0.4
chr5_14261499_14261650	0.34	TRIO	trio Rho guanine nucleotide exchange factor	29512	0.26
chr1_210431394_210431545	0.34	SERTAD4-AS1	SERTAD4 antisense RNA 1	24077	0.19
chr5_14174403_14174686	0.33	TRIO	trio Rho guanine nucleotide exchange factor	9363	0.32
chr6_52376693_52376847	0.33	TRAM2	translocation associated membrane protein 2	64943	0.11
chr18_52454307_52454540	0.32	RAB27B	RAB27B, member RAS oncogene family	41007	0.2
chr1_27855366_27855678	0.32	RP1-159A19.4		3206	0.23
chr14_36538512_36538663	0.31	ENSG00000212071	.	127187	0.05
chr13_40105934_40106139	0.31	LHFP	lipoma HMGIC fusion partner	71272	0.11
chr11_10696838_10697077	0.30	MRVI1	murine retrovirus integration site 1 homolog	18104	0.17
chr17_40128851_40129002	0.29	DNAJC7	DnaJ (Hsp40) homolog, subfamily C, member 7	5413	0.13
chr9_82104147_82104538	0.29	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	82346	0.12
chr21_43953040_43953239	0.29	SLC37A1	solute carrier family 37 (glucose-6-phosphate transporter), member 1	18505	0.13
chr16_80755255_80755539	0.29	CTD-2055G21.1		14860	0.21
chr2_9375733_9375964	0.29	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	28954	0.23
chr17_74526963_74527181	0.29	CYGB	cytoglobin	1075	0.29
chr17_3545041_3545192	0.29	CTNS	cystinosin, lysosomal cystine transporter	1675	0.21
chr2_47313454_47313781	0.28	AC073283.7		18656	0.18
chr9_93880537_93881196	0.28	AUH	AU RNA binding protein/enoyl-CoA hydratase	243311	0.02
chr17_9160012_9160446	0.28	RP11-85B7.4		26262	0.21
chr11_69263417_69264003	0.28	CCND1	cyclin D1	192145	0.03
chr10_129706485_129706650	0.28	PTPRE	protein tyrosine phosphatase, receptor type, E	1151	0.53
chr7_104614373_104614618	0.28	ENSG00000251911	.	2761	0.25
chr6_89744917_89745362	0.27	ENSG00000223001	.	28270	0.13
chr15_35598915_35599148	0.27	ENSG00000265102	.	65534	0.14
chr9_137537253_137537404	0.27	COL5A1	collagen, type V, alpha 1	3708	0.25
chr6_111886228_111886379	0.27	TRAF3IP2-AS1	TRAF3IP2 antisense RNA 1	151	0.95
chr14_105216209_105216503	0.27	SIVA1	SIVA1, apoptosis-inducing factor	3081	0.16
chr1_9952782_9953028	0.26	CTNNBIP1	catenin, beta interacting protein 1	390	0.81
chr2_33516894_33517045	0.26	LTBP1	latent transforming growth factor beta binding protein 1	254	0.93
chr1_41235374_41235525	0.26	ENSG00000207962	.	12493	0.12
chr6_3139599_3139904	0.26	BPHL	biphenyl hydrolase-like (serine hydrolase)	908	0.5
chr5_14445022_14445319	0.26	TRIO	trio Rho guanine nucleotide exchange factor	43387	0.2
chrX_153770737_153771284	0.26	IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	532	0.58
chr1_59602387_59602647	0.26	FGGY	FGGY carbohydrate kinase domain containing	159793	0.04
chr3_185375823_185376288	0.25	SENP2	SUMO1/sentrin/SMT3 specific peptidase 2	44912	0.15
chr7_73497247_73497589	0.25	LIMK1	LIM domain kinase 1	155	0.96
chr1_61637743_61637894	0.25	RP4-802A10.1		47413	0.17
chr17_26312086_26312243	0.25	ENSG00000251818	.	33632	0.13
chr12_48147567_48147718	0.25	SLC48A1	solute carrier family 48 (heme transporter), member 1	57	0.96
chr4_41062724_41062875	0.24	ENSG00000199790	.	23825	0.18
chr12_15112233_15112384	0.24	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	1892	0.3
chr1_95328697_95328848	0.24	SLC44A3	solute carrier family 44, member 3	4115	0.22
chr8_97594056_97594225	0.24	SDC2	syndecan 2	1563	0.51
chr10_26845646_26845984	0.24	ENSG00000199733	.	47297	0.17
chr2_64343006_64343324	0.24	AC074289.1		27208	0.19
chr2_11343535_11343897	0.24	ENSG00000207267	.	30398	0.15
chr16_29280883_29281034	0.24	RP11-231C14.6		42713	0.13
chr2_232229722_232230070	0.24	ENSG00000263641	.	2477	0.26
chr8_18953240_18953562	0.23	PSD3	pleckstrin and Sec7 domain containing 3	11161	0.29
chr8_139855770_139855921	0.23	COL22A1	collagen, type XXII, alpha 1	64040	0.16
chr16_73104328_73104761	0.23	ZFHX3	zinc finger homeobox 3	10947	0.24
chr17_30822967_30823118	0.23	RP11-466A19.1		488	0.69
chr17_62038673_62039025	0.23	SCN4A	sodium channel, voltage-gated, type IV, alpha subunit	11429	0.12
chr1_32049799_32049950	0.23	TINAGL1	tubulointerstitial nephritis antigen-like 1	7735	0.14
chr10_114021204_114021502	0.23	TECTB	tectorin beta	22140	0.23
chr3_31212208_31212359	0.23	ENSG00000265376	.	9004	0.28
chr12_52569964_52570127	0.23	KRT80	keratin 80	15739	0.12
chr12_78450993_78451144	0.22	RP11-136F16.1		34449	0.22
chr1_8740143_8740294	0.22	RERE	arginine-glutamic acid dipeptide (RE) repeats	23060	0.23
chr8_105378884_105379035	0.22	DCSTAMP	dendrocyte expressed seven transmembrane protein	18190	0.18
chr22_38573907_38574208	0.22	PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)	2354	0.22
chr17_983655_983915	0.22	ABR	active BCR-related	1399	0.45
chr9_127116150_127116301	0.22	ENSG00000264237	.	3415	0.26
chr14_59721391_59721542	0.22	DAAM1	dishevelled associated activator of morphogenesis 1	8707	0.3
chr10_50887461_50887643	0.22	C10orf53	chromosome 10 open reading frame 53	145	0.97
chr19_6463883_6464309	0.22	CRB3	crumbs homolog 3 (Drosophila)	194	0.84
chr3_168823031_168823291	0.21	MECOM	MDS1 and EVI1 complex locus	22661	0.28
chr17_40998909_40999245	0.21	AOC2	amine oxidase, copper containing 2 (retina-specific)	2459	0.12
chr6_43091623_43091783	0.21	PTK7	protein tyrosine kinase 7	6626	0.13
chr2_174937001_174937255	0.21	SP3	Sp3 transcription factor	106698	0.07
chr11_19702330_19702481	0.21	NAV2	neuron navigator 2	32476	0.19
chr1_183250951_183251102	0.21	NMNAT2	nicotinamide nucleotide adenylyltransferase 2	22983	0.23
chr2_238066163_238066314	0.21	COPS8	COP9 signalosome subunit 8	71652	0.1
chr6_15897284_15897435	0.21	MYLIP	myosin regulatory light chain interacting protein	231997	0.02
chr21_43460258_43460538	0.21	UMODL1	uromodulin-like 1	22670	0.16
chr14_33698651_33698802	0.21	NPAS3	neuronal PAS domain protein 3	14208	0.32
chr13_33000508_33000853	0.21	N4BP2L1	NEDD4 binding protein 2-like 1	1471	0.43
chr13_111033798_111033949	0.20	ENSG00000238629	.	32679	0.18
chr1_53601169_53601320	0.20	SLC1A7	solute carrier family 1 (glutamate transporter), member 7	7005	0.14
chr2_102079958_102080109	0.20	RFX8	RFX family member 8, lacking RFX DNA binding domain	10704	0.26
chr8_26485560_26485711	0.20	DPYSL2	dihydropyrimidinase-like 2	49714	0.17
chr19_47239966_47240117	0.20	ENSG00000222614	.	472	0.64
chr3_127454470_127454692	0.20	MGLL	monoglyceride lipase	619	0.78
chr3_72378625_72378776	0.20	ENSG00000212070	.	67121	0.13
chr4_56042024_56042324	0.20	ENSG00000239545	.	39905	0.15
chr19_2188884_2189035	0.20	DOT1L	DOT1-like histone H3K79 methyltransferase	24630	0.08
chrX_48350514_48350665	0.20	FTSJ1	FtsJ RNA methyltransferase homolog 1 (E. coli)	14209	0.1
chr16_85597214_85597712	0.20	GSE1	Gse1 coiled-coil protein	47552	0.14
chr2_120980604_120980755	0.20	TMEM185B	transmembrane protein 185B	305	0.89
chr12_1579383_1579534	0.20	WNT5B	wingless-type MMTV integration site family, member 5B	59599	0.11
chr12_112043846_112043997	0.20	ATXN2	ataxin 2	6441	0.18
chr21_39850220_39850518	0.20	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	19976	0.28
chr11_62369886_62370188	0.20	MTA2	metastasis associated 1 family, member 2	725	0.33
chr2_101507765_101507916	0.20	NPAS2	neuronal PAS domain protein 2	33768	0.17
chr17_773553_773704	0.20	NXN	nucleoredoxin	6277	0.16
chr6_157469967_157470240	0.19	ARID1B	AT rich interactive domain 1B (SWI1-like)	58	0.98
chr22_41050157_41050308	0.19	MKL1	megakaryoblastic leukemia (translocation) 1	17537	0.19
chr1_44705174_44705804	0.19	ERI3-IT1	ERI3 intronic transcript 1 (non-protein coding)	4456	0.21
chr2_40663401_40663552	0.19	SLC8A1	solute carrier family 8 (sodium/calcium exchanger), member 1	6032	0.34
chr7_41187429_41187580	0.19	AC005160.3		372347	0.01
chr9_136325577_136325728	0.19	CACFD1	calcium channel flower domain containing 1	497	0.68
chr3_127484247_127484497	0.19	MGLL	monoglyceride lipase	18479	0.22
chr17_39240048_39240199	0.19	KRTAP4-7	keratin associated protein 4-7	336	0.68
chr12_69007841_69008681	0.19	RAP1B	RAP1B, member of RAS oncogene family	3456	0.26
chr21_33846975_33847126	0.19	EVA1C	eva-1 homolog C (C. elegans)	46408	0.11
chr15_68645681_68645891	0.19	FEM1B	fem-1 homolog b (C. elegans)	63236	0.11
chr6_43958464_43958740	0.19	C6orf223	chromosome 6 open reading frame 223	9715	0.17
chr16_85590754_85591408	0.19	GSE1	Gse1 coiled-coil protein	53934	0.13
chr11_107799088_107799595	0.19	RAB39A	RAB39A, member RAS oncogene family	112	0.77
chr15_73979466_73979617	0.19	CD276	CD276 molecule	2194	0.36
chr6_26432216_26432367	0.19	BTN3A3	butyrophilin, subfamily 3, member A3	8409	0.11
chr2_121528712_121528929	0.19	GLI2	GLI family zinc finger 2	21165	0.27
chr7_5674087_5674709	0.19	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	40081	0.12
chr13_111866660_111867080	0.19	ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	9234	0.25
chr17_40554278_40554429	0.19	ENSG00000221020	.	3326	0.15
chr9_36158585_36158800	0.18	CCIN	calicin	10697	0.17
chr13_30567918_30568069	0.18	LINC00572	long intergenic non-protein coding RNA 572	67205	0.13
chr7_101524016_101524398	0.18	CTA-339C12.1		56198	0.12
chr19_52270463_52270746	0.18	FPR2	formyl peptide receptor 2	1027	0.41
chr8_145692200_145692386	0.18	KIFC2	kinesin family member C2	645	0.36
chr2_121673188_121673339	0.18	GLI2	GLI family zinc finger 2	118342	0.06
chr9_81760534_81760685	0.18	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	426079	0.01
chr15_63322256_63322433	0.18	TPM1	tropomyosin 1 (alpha)	12487	0.18
chr17_7837465_7837616	0.18	CNTROB	centrobin, centrosomal BRCA2 interacting protein	1142	0.27
chr10_80997764_80997915	0.18	ZMIZ1	zinc finger, MIZ-type containing 1	68136	0.12
chr10_105251971_105252122	0.18	NEURL1	neuralized E3 ubiquitin protein ligase 1	1690	0.23
chr14_104018069_104018220	0.18	ENSG00000252469	.	1462	0.17
chr21_46852549_46852700	0.18	COL18A1-AS1	COL18A1 antisense RNA 1	7639	0.17
chr3_8499776_8500071	0.18	LMCD1-AS1	LMCD1 antisense RNA 1 (head to head)	43361	0.15
chr10_81000941_81001092	0.18	ZMIZ1	zinc finger, MIZ-type containing 1	64959	0.13
chr2_30454852_30455048	0.18	LBH	limb bud and heart development	69	0.98
chr21_42484961_42485351	0.18	LINC00323	long intergenic non-protein coding RNA 323	34194	0.15
chr1_108661134_108661345	0.18	SLC25A24	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24	74201	0.09
chr11_61809719_61809884	0.18	AP003733.1	Uncharacterized protein; cDNA FLJ36460 fis, clone THYMU2014801	74348	0.07
chr20_2795832_2795989	0.18	C20orf141	chromosome 20 open reading frame 141	253	0.52
chr12_124870235_124870636	0.18	NCOR2	nuclear receptor corepressor 2	2935	0.37
chr13_25485405_25485556	0.18	CENPJ	centromere protein J	7348	0.24
chr19_4391069_4391613	0.18	SH3GL1	SH3-domain GRB2-like 1	734	0.43
chr1_87244168_87244361	0.18	SH3GLB1	SH3-domain GRB2-like endophilin B1	73686	0.09
chr8_85095605_85095756	0.18	RALYL	RALY RNA binding protein-like	89	0.99
chr17_81021007_81021158	0.18	B3GNTL1	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1	11396	0.21
chr2_113470510_113470661	0.18	NT5DC4	5'-nucleotidase domain containing 4	8478	0.2
chr2_207974591_207974747	0.18	ENSG00000253008	.	128	0.96
chr22_38597727_38597878	0.18	MAFF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F	87	0.95
chr6_37961556_37961707	0.18	ZFAND3	zinc finger, AN1-type domain 3	63896	0.12
chr3_13549513_13549664	0.17	FBLN2	fibulin 2	24236	0.16
chr7_92369983_92370216	0.17	ENSG00000206763	.	38971	0.18
chr13_101999259_101999410	0.17	NALCN	sodium leak channel, non-selective	52171	0.18
chr3_148184411_148184664	0.17	AGTR1	angiotensin II receptor, type 1	231034	0.02
chr9_86784994_86785145	0.17	RP11-380F14.2		108065	0.06
chr1_23710189_23710340	0.17	TCEA3	transcription elongation factor A (SII), 3	3648	0.16
chr3_149865017_149865176	0.17	RP11-167H9.4		49277	0.15
chr3_8890314_8890465	0.17	RAD18	RAD18 homolog (S. cerevisiae)	53693	0.11
chr16_79204965_79205116	0.17	RP11-556H2.2		65186	0.11
chrY_2709779_2709930	0.17	RPS4Y1	ribosomal protein S4, Y-linked 1	107	0.98
chr17_39261210_39261361	0.17	KRTAP4-9	keratin associated protein 4-9	299	0.71
chr10_135073858_135074032	0.17	MIR202HG	MIR202 host gene (non-protein coding)	12550	0.1
chr14_62004306_62004579	0.17	RP11-47I22.1		7563	0.2
chr18_494818_494969	0.17	COLEC12	collectin sub-family member 12	5829	0.22
chr12_19699587_19699738	0.17	AEBP2	AE binding protein 2	46599	0.18
chr8_41656318_41656469	0.17	ANK1	ankyrin 1, erythrocytic	1253	0.45
chr2_46343393_46343544	0.17	AC017006.2		37501	0.18
chr3_46543509_46543660	0.17	RTP3	receptor (chemosensory) transporter protein 3	4603	0.17
chr1_20820718_20821010	0.17	CAMK2N1	calcium/calmodulin-dependent protein kinase II inhibitor 1	8151	0.19
chr1_94127454_94127736	0.17	BCAR3	breast cancer anti-estrogen resistance 3	19331	0.22
chr3_66083676_66083827	0.17	SLC25A26	solute carrier family 25 (S-adenosylmethionine carrier), member 26	35534	0.18
chr3_126398342_126398493	0.17	TXNRD3	thioredoxin reductase 3	24419	0.17
chr1_153508734_153509122	0.17	S100A6	S100 calcium binding protein A6	208	0.85
chr12_92378267_92378418	0.17	C12orf79	chromosome 12 open reading frame 79	152455	0.04
chr11_116966114_116966583	0.17	SIK3	SIK family kinase 3	2639	0.22
chr9_127051927_127052078	0.17	NEK6	NIMA-related kinase 6	2248	0.29
chr5_145564514_145564665	0.16	LARS	leucyl-tRNA synthetase	2366	0.3
chr1_113265986_113266348	0.16	FAM19A3	family with sequence similarity 19 (chemokine (C-C motif)-like), member A3	2968	0.15
chr20_62530297_62530448	0.16	DNAJC5	DnaJ (Hsp40) homolog, subfamily C, member 5	3837	0.09
chr12_71439781_71440156	0.16	CTD-2021H9.2		58338	0.13
chr4_164253447_164254003	0.16	NPY1R	neuropeptide Y receptor Y1	23	0.98
chr2_201652506_201652946	0.16	ENSG00000201737	.	12419	0.12
chr22_41418613_41418788	0.16	ENSG00000222698	.	22801	0.13
chr5_41793545_41793696	0.16	OXCT1	3-oxoacid CoA transferase 1	862	0.71
chr16_4428001_4428209	0.16	VASN	vasorin	6256	0.13
chr3_25823149_25824090	0.16	NGLY1	N-glycanase 1	744	0.48
chr6_109745594_109745745	0.16	ENSG00000239160	.	9774	0.12
chr16_57095437_57095664	0.16	RP11-322D14.2		3141	0.17
chr18_32288595_32288746	0.16	DTNA	dystrobrevin, alpha	1578	0.51
chr3_111686013_111686245	0.16	ABHD10	abhydrolase domain containing 10	11728	0.19
chr20_43332745_43332896	0.16	RP11-445H22.3		8083	0.13
chr5_54179191_54179535	0.16	ENSG00000221073	.	30587	0.19
chr19_15377356_15377507	0.16	BRD4	bromodomain containing 4	13831	0.16
chr17_48718114_48718630	0.16	ABCC3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	6154	0.13
chr1_198849285_198849436	0.16	ENSG00000207759	.	21078	0.22

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TFEC_MITF_ARNTL_BHLHE41

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0035581	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.2	GO:2000143	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.1	0.5	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1	0.3	GO:0046952	ketone body catabolic process(GO:0046952)
0.1	0.2	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0006452	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0	0.2	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.4	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:0021508	floor plate formation(GO:0021508)
0.0	0.1	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.2	GO:0007567	parturition(GO:0007567)
0.0	0.1	GO:0060088	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.2	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0	0.2	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.1	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.2	GO:0016056	rhodopsin mediated signaling pathway(GO:0016056)
0.0	0.0	GO:0003099	positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0	0.1	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.0	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.0	GO:0006222	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.1	GO:0032049	phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0	0.1	GO:0033860	regulation of NAD(P)H oxidase activity(GO:0033860)
0.0	0.1	GO:0048289	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0046628	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.1	GO:0021819	layer formation in cerebral cortex(GO:0021819)
0.0	0.1	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.0	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.0	0.1	GO:0050665	hydrogen peroxide biosynthetic process(GO:0050665)
0.0	0.1	GO:0010996	response to auditory stimulus(GO:0010996)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0070570	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.1	GO:0006910	phagocytosis, recognition(GO:0006910)
0.0	0.0	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.2	GO:0045773	positive regulation of axon extension(GO:0045773)
0.0	0.0	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.2	GO:0061245	establishment or maintenance of apical/basal cell polarity(GO:0035088) establishment or maintenance of bipolar cell polarity(GO:0061245)
0.0	0.1	GO:0043587	tongue morphogenesis(GO:0043587)
0.0	0.0	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.1	GO:0046855	phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0042640	anagen(GO:0042640)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.2	GO:0050812	acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.0	GO:0010979	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0	0.1	GO:0031000	response to caffeine(GO:0031000)
0.0	0.1	GO:1901976	regulation of cell cycle checkpoint(GO:1901976)
0.0	0.0	GO:0060453	regulation of gastric acid secretion(GO:0060453)
0.0	0.0	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.1	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.0	GO:0061072	iris morphogenesis(GO:0061072)
0.0	0.1	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.0	GO:1900121	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.1	GO:0014821	phasic smooth muscle contraction(GO:0014821)
0.0	0.0	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0	0.1	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.1	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0002478	antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:0071681	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0	0.0	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.0	GO:2000644	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.1	GO:0001975	response to amphetamine(GO:0001975)
0.0	0.0	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.0	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.0	GO:0006663	platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0	0.0	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.0	GO:0048596	embryonic camera-type eye morphogenesis(GO:0048596)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.1	GO:0006451	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.1	GO:1901532	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0060027	convergent extension involved in gastrulation(GO:0060027)
0.0	0.0	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0021955	central nervous system neuron axonogenesis(GO:0021955)
0.0	0.0	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.0	GO:0051503	adenine nucleotide transport(GO:0051503)
0.0	0.0	GO:0045079	negative regulation of chemokine production(GO:0032682) negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.0	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.1	GO:0006000	fructose metabolic process(GO:0006000)
0.0	0.1	GO:0048745	smooth muscle tissue development(GO:0048745)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.0	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0001502	cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0	0.0	GO:0060841	venous blood vessel development(GO:0060841)
0.0	0.0	GO:0019240	citrulline biosynthetic process(GO:0019240)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.1	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.1	GO:0031045	dense core granule(GO:0031045)
0.2	GO:0008385	IkappaB kinase complex(GO:0008385)
0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.1	GO:0042405	nuclear inclusion body(GO:0042405)
0.1	GO:0043260	laminin-11 complex(GO:0043260)
0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1	GO:0042824	MHC class I peptide loading complex(GO:0042824)
0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	GO:0070695	FHF complex(GO:0070695)
0.1	GO:0031512	motile primary cilium(GO:0031512)
0.1	GO:0031143	pseudopodium(GO:0031143)
0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.2	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	GO:0032059	bleb(GO:0032059)
0.1	GO:0030315	T-tubule(GO:0030315)
0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.1	GO:0001917	photoreceptor inner segment(GO:0001917)
0.1	GO:0005915	zonula adherens(GO:0005915)
0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.1	GO:0034451	centriolar satellite(GO:0034451)
0.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.1	GO:0031095	platelet dense tubular network membrane(GO:0031095)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.1	0.2	GO:0001601	peptide YY receptor activity(GO:0001601)
0.1	0.2	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.2	GO:0050542	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.3	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.2	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.2	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0048185	activin binding(GO:0048185)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.2	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.4	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.1	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.0	GO:0050543	icosatetraenoic acid binding(GO:0050543)
0.0	0.1	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.1	GO:0046980	tapasin binding(GO:0046980)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.1	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.3	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.1	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.0	0.0	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0071617	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.0	GO:0005534	galactose binding(GO:0005534)
0.0	0.0	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.1	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.0	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.0	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.0	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.1	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.0	GO:0004739	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0051378	serotonin binding(GO:0051378)
0.0	0.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.0	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.0	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.0	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.0	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.1	GO:0051636	obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0004312	fatty acid synthase activity(GO:0004312)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.6	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.3	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.3	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.2	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.2	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.2	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.2	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1	REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	Genes involved in NRIF signals cell death from the nucleus
0.1	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.2	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3	REACTOME ACYL CHAIN REMODELLING OF PC	Genes involved in Acyl chain remodelling of PC
0.1	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.1	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.3	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.1	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors