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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for THRA_RXRB

Z-value: 1.35

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Transcription factors associated with THRA_RXRB

Gene Symbol	Gene ID	Gene Info
THRA Ensembl NCBI GeneCards UniProt	ENSG00000126351.8	THRA
RXRB Ensembl NCBI GeneCards UniProt	ENSG00000204231.6	RXRB

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
THRA	chr17_38218268_38218459	83	0.920685	0.71	3.3e-02	Click!
THRA	chr17_38229780_38229931	1511	0.274048	0.70	3.5e-02	Click!
THRA	chr17_38218492_38218643	121	0.914171	0.60	8.7e-02	Click!
THRA	chr17_38232565_38232716	4296	0.136826	0.57	1.1e-01	Click!
THRA	chr17_38223510_38223773	1515	0.271184	0.51	1.6e-01	Click!

Activity of the THRA_RXRB motif across conditions

Conditions sorted by the z-value of the THRA_RXRB motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_107819281_107819678	0.72	CD47	CD47 molecule	9607	0.3
chr2_127422232_127422532	0.53	GYPC	glycophorin C (Gerbich blood group)	8622	0.27
chr15_78336776_78336956	0.50	ENSG00000221476	.	5993	0.15
chr7_150453228_150453688	0.47	GIMAP5	GTPase, IMAP family member 5	19022	0.14
chr6_36647112_36647373	0.44	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	744	0.58
chr3_13023386_13023537	0.44	IQSEC1	IQ motif and Sec7 domain 1	5075	0.29
chr10_129678837_129678988	0.44	CLRN3	clarin 3	12299	0.22
chr2_7050734_7050964	0.43	RNF144A	ring finger protein 144A	6674	0.18
chr15_85264382_85264668	0.42	SEC11A	SEC11 homolog A (S. cerevisiae)	4578	0.15
chr11_118099433_118099584	0.42	AMICA1	adhesion molecule, interacts with CXADR antigen 1	3699	0.17
chrX_48543101_48543693	0.41	WAS	Wiskott-Aldrich syndrome	1229	0.35
chr20_2722949_2723333	0.41	EBF4	early B-cell factor 4	36254	0.09
chr17_66344922_66345112	0.41	ARSG	arylsulfatase G	57358	0.1
chr1_200854769_200854937	0.39	C1orf106	chromosome 1 open reading frame 106	5323	0.19
chr6_116785564_116786071	0.39	RP1-93H18.6		962	0.41
chr17_8859556_8859835	0.39	PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	9329	0.24
chr17_75913110_75913444	0.38	ENSG00000238898	.	2903	0.3
chr5_126308801_126309244	0.38	MARCH3	membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase	55102	0.15
chr12_124491346_124491497	0.38	ZNF664	zinc finger protein 664	33579	0.08
chr12_93981713_93981864	0.38	SOCS2	suppressor of cytokine signaling 2	12954	0.18
chr5_126312253_126312404	0.38	MARCH3	membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase	54172	0.15
chr17_75840839_75841130	0.38	FLJ45079		37675	0.18
chr21_44010697_44010940	0.38	AP001625.6		28774	0.14
chr1_155916745_155916975	0.37	ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	4679	0.1
chr2_174328085_174328236	0.37	CDCA7	cell division cycle associated 7	108560	0.07
chr3_107791032_107791183	0.37	CD47	CD47 molecule	12728	0.3
chr4_38916757_38916925	0.37	ENSG00000207944	.	47188	0.11
chr6_159461814_159462217	0.37	TAGAP	T-cell activation RhoGTPase activating protein	4035	0.22
chr8_144939517_144939748	0.36	EPPK1	epiplakin 1	13000	0.09
chr16_84641040_84641383	0.36	COTL1	coactosin-like 1 (Dictyostelium)	10454	0.17
chr15_70744544_70744849	0.36	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	249924	0.02
chr2_10518114_10518365	0.36	HPCAL1	hippocalcin-like 1	41908	0.14
chr16_30468718_30468869	0.36	ENSG00000202476	.	3375	0.08
chr8_42000299_42000484	0.36	RP11-589C21.5		9890	0.17
chr3_150888432_150888616	0.36	ENSG00000199994	.	17362	0.16
chr5_176783043_176783194	0.36	RGS14	regulator of G-protein signaling 14	1720	0.2
chrX_128921545_128921805	0.35	SASH3	SAM and SH3 domain containing 3	7715	0.2
chr1_1830831_1831010	0.35	RP1-140A9.1		8010	0.13
chr9_86908771_86909182	0.35	RP11-380F14.2		15842	0.25
chr2_99087636_99087787	0.35	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	26298	0.2
chr2_198072900_198073187	0.34	ANKRD44	ankyrin repeat domain 44	10281	0.21
chr16_29672717_29672868	0.34	SPN	sialophorin	1508	0.26
chr14_90148740_90149294	0.34	ENSG00000200312	.	29838	0.14
chr1_169574716_169574995	0.34	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	13602	0.2
chr5_132483935_132484150	0.34	CTB-49A3.2		12088	0.22
chr15_76222456_76222700	0.34	FBXO22	F-box protein 22	2563	0.27
chr8_135324203_135324532	0.34	ZFAT	zinc finger and AT hook domain containing	198058	0.03
chr13_100071950_100072184	0.33	ENSG00000266207	.	33656	0.15
chr1_109188369_109188646	0.33	HENMT1	HEN1 methyltransferase homolog 1 (Arabidopsis)	15170	0.19
chr7_138731189_138731354	0.33	ZC3HAV1L	zinc finger CCCH-type, antiviral 1-like	10496	0.21
chr3_39300527_39300690	0.33	CX3CR1	chemokine (C-X3-C motif) receptor 1	20917	0.18
chr7_150359146_150359387	0.33	GIMAP2	GTPase, IMAP family member 2	23522	0.15
chr14_100546662_100546850	0.33	CTD-2376I20.1		5541	0.16
chr14_104855874_104856139	0.33	ENSG00000222761	.	11379	0.26
chr5_133467618_133467806	0.33	TCF7	transcription factor 7 (T-cell specific, HMG-box)	8403	0.21
chr17_56247502_56247750	0.33	OR4D2	olfactory receptor, family 4, subfamily D, member 2	609	0.66
chr1_9717399_9717821	0.33	C1orf200	chromosome 1 open reading frame 200	2966	0.22
chr6_90793986_90794257	0.32	ENSG00000222078	.	82896	0.09
chr1_236101876_236102050	0.32	ENSG00000206803	.	23248	0.18
chr15_91372602_91372985	0.32	CTD-3094K11.1		10161	0.13
chr9_135992327_135992532	0.32	RALGDS	ral guanine nucleotide dissociation stimulator	4134	0.16
chr7_37393575_37393854	0.32	ELMO1	engulfment and cell motility 1	442	0.83
chr11_67414919_67415070	0.32	ACY3	aspartoacylase (aminocyclase) 3	60	0.95
chr11_63973377_63973615	0.32	FERMT3	fermitin family member 3	654	0.44
chr15_64750062_64750402	0.32	ZNF609	zinc finger protein 609	2709	0.18
chr2_135433313_135433464	0.31	TMEM163	transmembrane protein 163	43182	0.2
chr6_34250869_34251020	0.31	C6orf1	chromosome 6 open reading frame 1	33697	0.16
chr1_154464906_154465057	0.31	SHE	Src homology 2 domain containing E	3339	0.16
chr5_39155242_39155486	0.31	FYB	FYN binding protein	47765	0.15
chr3_50636542_50636693	0.31	CISH	cytokine inducible SH2-containing protein	12586	0.14
chr16_67586263_67586449	0.31	FAM65A	family with sequence similarity 65, member A	8059	0.09
chr5_10505521_10505706	0.31	RP11-1C1.5	Uncharacterized protein	3693	0.21
chr10_104830143_104830341	0.31	NT5C2	5'-nucleotidase, cytosolic II	23883	0.21
chr6_159454655_159454806	0.31	RP1-111C20.4		7752	0.19
chr15_29228523_29228674	0.31	APBA2	amyloid beta (A4) precursor protein-binding, family A, member 2	14758	0.23
chr2_27109662_27109955	0.31	DPYSL5	dihydropyrimidinase-like 5	38432	0.13
chr16_57175250_57175426	0.31	CPNE2	copine II	22227	0.12
chr4_124538385_124538719	0.31	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	217429	0.02
chr9_117144402_117144633	0.31	AKNA	AT-hook transcription factor	4602	0.23
chr7_50357344_50357742	0.31	IKZF1	IKAROS family zinc finger 1 (Ikaros)	9225	0.29
chr18_60198457_60198694	0.31	ZCCHC2	zinc finger, CCHC domain containing 2	7723	0.28
chr1_47654400_47654551	0.31	PDZK1IP1	PDZK1 interacting protein 1	1252	0.4
chr2_8519563_8519714	0.31	AC011747.7		296258	0.01
chr22_39296706_39296951	0.31	CBX6	chromobox homolog 6	28509	0.12
chr3_46416206_46416357	0.30	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	2120	0.26
chr22_40798855_40799170	0.30	SGSM3	small G protein signaling modulator 3	5305	0.17
chr1_167570221_167570504	0.30	RCSD1	RCSD domain containing 1	28968	0.15
chr19_49838163_49838543	0.30	CD37	CD37 molecule	300	0.78
chr19_7402225_7402456	0.30	CTB-133G6.1		11508	0.16
chr11_44936863_44937276	0.30	TSPAN18	tetraspanin 18	9111	0.25
chr6_37485958_37486109	0.30	CCDC167	coiled-coil domain containing 167	18335	0.19
chr2_8716699_8716875	0.30	AC011747.7		99109	0.08
chr2_158278417_158278728	0.30	CYTIP	cytohesin 1 interacting protein	17354	0.21
chr13_110222272_110222771	0.29	LINC00676	long intergenic non-protein coding RNA 676	158108	0.04
chr1_12233372_12233638	0.29	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	6445	0.17
chr14_93533102_93533332	0.29	ITPK1	inositol-tetrakisphosphate 1-kinase	514	0.5
chr8_24134022_24134173	0.29	ADAM28	ADAM metallopeptidase domain 28	17456	0.26
chr8_6584199_6584352	0.29	AGPAT5	1-acylglycerol-3-phosphate O-acyltransferase 5	18061	0.17
chr5_53912958_53913109	0.29	SNX18	sorting nexin 18	99440	0.08
chr1_198529109_198529554	0.29	ATP6V1G3	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	19256	0.26
chr4_2837237_2837388	0.29	ADD1	adducin 1 (alpha)	8272	0.19
chr2_16105641_16106067	0.29	ENSG00000243541	.	14751	0.18
chr22_45028998_45029149	0.29	PRR5	proline rich 5 (renal)	35520	0.18
chr3_178793021_178793370	0.29	ZMAT3	zinc finger, matrin-type 3	3128	0.27
chr14_61911054_61911390	0.29	PRKCH	protein kinase C, eta	1946	0.42
chr17_76779813_76780089	0.29	CYTH1	cytohesin 1	1572	0.38
chr7_73630981_73631230	0.29	LAT2	linker for activation of T cells family, member 2	6752	0.16
chr1_247336048_247336203	0.29	ZNF124	zinc finger protein 124	807	0.56
chr10_73494821_73495244	0.29	C10orf105	chromosome 10 open reading frame 105	2549	0.3
chr22_24058094_24058402	0.29	AP000347.2		1234	0.32
chr2_43610834_43610985	0.29	ENSG00000252804	.	24537	0.25
chr22_23134104_23134282	0.28	ENSG00000207833	.	784	0.23
chr9_132658123_132658578	0.28	FNBP1	formin binding protein 1	23239	0.15
chr20_39780023_39780174	0.28	RP1-1J6.2		13455	0.19
chr11_3969138_3969471	0.28	STIM1	stromal interaction molecule 1	731	0.66
chr5_75720501_75720652	0.28	IQGAP2	IQ motif containing GTPase activating protein 2	20327	0.26
chr11_48039113_48039300	0.28	AC103828.1		1799	0.39
chr5_171333279_171333614	0.28	FBXW11	F-box and WD repeat domain containing 11	71314	0.11
chr1_227936240_227936391	0.28	SNAP47	synaptosomal-associated protein, 47kDa	551	0.67
chr2_198167309_198167571	0.28	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	197	0.93
chr14_93134593_93134845	0.28	RIN3	Ras and Rab interactor 3	15873	0.24
chr14_28295050_28295241	0.28	ENSG00000223164	.	164066	0.04
chr7_132118427_132118619	0.28	AC011625.1		81430	0.1
chr17_74269143_74269364	0.28	QRICH2	glutamine rich 2	7185	0.13
chr5_141282643_141282794	0.28	KIAA0141	KIAA0141	20655	0.14
chr8_6287473_6287678	0.28	RP11-115C21.2		22912	0.21
chr20_31111792_31112136	0.28	C20orf112	chromosome 20 open reading frame 112	3307	0.23
chr14_21269173_21269324	0.28	RNASE1	ribonuclease, RNase A family, 1 (pancreatic)	1317	0.31
chr10_7525377_7526075	0.28	ENSG00000207453	.	3045	0.32
chr4_185683459_185683704	0.28	ACSL1	acyl-CoA synthetase long-chain family member 1	4275	0.22
chr1_100877624_100878071	0.28	ENSG00000216067	.	33516	0.16
chr8_134086193_134086434	0.28	SLA	Src-like-adaptor	13710	0.23
chr6_53209989_53210148	0.27	ELOVL5	ELOVL fatty acid elongase 5	3519	0.27
chr17_7454664_7454994	0.27	TNFSF12	tumor necrosis factor (ligand) superfamily, member 12	2358	0.08
chr17_63022313_63022486	0.27	RP11-583F2.5		25628	0.14
chr5_118619331_118619759	0.27	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	15096	0.18
chr3_43298637_43298793	0.27	SNRK	SNF related kinase	29289	0.16
chr15_91228796_91228947	0.27	RP11-387D10.3		24901	0.13
chr14_61827530_61827767	0.27	PRKCH	protein kinase C, eta	144	0.97
chr1_9486742_9486893	0.27	ENSG00000252956	.	11020	0.24
chr20_48969794_48969957	0.27	ENSG00000244376	.	76145	0.1
chr14_91544790_91544971	0.27	ENSG00000252644	.	12541	0.16
chr3_141989336_141989501	0.27	GK5	glycerol kinase 5 (putative)	44969	0.16
chr13_114817282_114817433	0.27	RASA3	RAS p21 protein activator 3	26081	0.22
chr16_3627581_3627750	0.27	NLRC3	NLR family, CARD domain containing 3	264	0.89
chr16_30392632_30392982	0.27	SEPT1	septin 1	945	0.31
chr12_132663008_132663169	0.27	GALNT9	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)	27249	0.14
chr16_50196893_50197200	0.27	PAPD5	PAP associated domain containing 5	9267	0.16
chr9_101900893_101901046	0.27	ENSG00000252942	.	7279	0.19
chr9_2023792_2024048	0.27	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1975	0.41
chr19_8632582_8633028	0.27	MYO1F	myosin IF	9517	0.11
chr7_37461432_37461682	0.27	ENSG00000200113	.	2326	0.3
chr14_105750101_105750417	0.27	BRF1	BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit	16546	0.15
chr19_17514773_17515020	0.27	BST2	bone marrow stromal cell antigen 2	1561	0.17
chr22_23164320_23164502	0.26	IGLV2-8	immunoglobulin lambda variable 2-8	742	0.25
chr6_158306516_158306953	0.26	RP3-403L10.3		7084	0.18
chr7_7963215_7963560	0.26	ENSG00000201747	.	17237	0.17
chr14_22964920_22965173	0.26	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	8875	0.1
chr1_206733046_206733294	0.26	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	2677	0.24
chr22_39920591_39920772	0.26	ATF4	activating transcription factor 4	4112	0.17
chr1_55668824_55669013	0.26	USP24	ubiquitin specific peptidase 24	11844	0.22
chr6_109770732_109770883	0.26	MICAL1	microtubule associated monooxygenase, calponin and LIM domain containing 1	179	0.91
chr1_167452877_167453134	0.26	RP11-104L21.2		25107	0.17
chr7_139468099_139468250	0.26	HIPK2	homeodomain interacting protein kinase 2	9343	0.23
chr11_48065545_48066080	0.26	AC103828.1		28405	0.17
chr17_72636963_72637310	0.26	CD300E	CD300e molecule	17239	0.12
chr5_142178337_142178630	0.26	ARHGAP26	Rho GTPase activating protein 26	26201	0.22
chr6_106324555_106324706	0.26	ENSG00000200198	.	27618	0.26
chr3_34060384_34060651	0.26	PDCD6IP	programmed cell death 6 interacting protein	220402	0.02
chr1_247367941_247368092	0.26	ENSG00000252516	.	53	0.96
chr8_71053263_71053636	0.26	NCOA2	nuclear receptor coactivator 2	7172	0.25
chr5_67527341_67527547	0.26	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	4982	0.28
chr12_108714499_108714650	0.26	CMKLR1	chemokine-like receptor 1	135	0.98
chr6_143865508_143865659	0.26	PHACTR2	phosphatase and actin regulator 2	7601	0.17
chr18_3723612_3723763	0.25	RP11-874J12.3		47743	0.13
chr18_43589850_43590001	0.25	ENSG00000222179	.	20014	0.17
chr1_154987014_154987262	0.25	ZBTB7B	zinc finger and BTB domain containing 7B	214	0.83
chr18_21549060_21549211	0.25	LAMA3	laminin, alpha 3	19278	0.17
chr8_37553639_37554052	0.25	ZNF703	zinc finger protein 703	576	0.66
chr6_157140981_157141263	0.25	RP11-230C9.3		39533	0.16
chr16_31497874_31498025	0.25	AC026471.6		1864	0.17
chr1_172694568_172694750	0.25	FASLG	Fas ligand (TNF superfamily, member 6)	66501	0.13
chr19_12442067_12442220	0.25	ZNF563	zinc finger protein 563	2163	0.24
chr22_43659141_43659490	0.25	SCUBE1	signal peptide, CUB domain, EGF-like 1	510	0.76
chr1_86907105_86907371	0.25	CLCA2	chloride channel accessory 2	17469	0.19
chr1_66773813_66773964	0.25	PDE4B	phosphodiesterase 4B, cAMP-specific	22523	0.27
chr1_100830416_100830661	0.25	CDC14A	cell division cycle 14A	12033	0.18
chr13_84712610_84712776	0.25	SLITRK1	SLIT and NTRK-like family, member 1	256165	0.02
chr5_176859524_176860060	0.25	GRK6	G protein-coupled receptor kinase 6	5937	0.1
chr15_31728916_31729103	0.25	KLF13	Kruppel-like factor 13	70652	0.13
chr2_218884404_218884588	0.25	TNS1	tensin 1	16778	0.16
chr20_55097345_55097496	0.25	FAM209A	family with sequence similarity 209, member A	2122	0.22
chr17_26070911_26071062	0.25	ENSG00000263472	.	41048	0.13
chr9_95822386_95822880	0.25	SUSD3	sushi domain containing 3	1572	0.37
chr1_112887579_112887730	0.25	ENSG00000238761	.	25972	0.2
chr1_1074452_1074741	0.25	C1orf159	chromosome 1 open reading frame 159	22855	0.07
chr4_2789296_2789952	0.25	SH3BP2	SH3-domain binding protein 2	5126	0.22
chr2_103511305_103511456	0.25	TMEM182	transmembrane protein 182	132908	0.05
chr10_91498741_91498892	0.25	KIF20B	kinesin family member 20B	37380	0.18
chr2_99090097_99090281	0.25	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	28776	0.2

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of THRA_RXRB

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.3	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.1	0.1	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.3	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.2	GO:0045056	transcytosis(GO:0045056)
0.1	0.2	GO:0090400	stress-induced premature senescence(GO:0090400)
0.1	0.3	GO:0045588	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.1	0.2	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1	0.2	GO:0033622	integrin activation(GO:0033622)
0.1	0.2	GO:0000042	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1	0.2	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.1	0.4	GO:0006198	cAMP catabolic process(GO:0006198)
0.1	0.2	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.1	0.5	GO:0006911	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.1	0.3	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.1	0.2	GO:0097576	vacuole fusion(GO:0097576)
0.1	0.2	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.1	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.3	GO:0010759	positive regulation of macrophage chemotaxis(GO:0010759)
0.0	0.2	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.1	GO:0002664	T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.0	0.4	GO:0015884	folic acid transport(GO:0015884)
0.0	0.0	GO:0002448	mast cell mediated immunity(GO:0002448)
0.0	0.1	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.1	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.2	GO:0002691	regulation of cellular extravasation(GO:0002691)
0.0	0.2	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.4	GO:0002418	immune response to tumor cell(GO:0002418)
0.0	0.1	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.1	GO:0035066	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.6	GO:0002639	positive regulation of immunoglobulin production(GO:0002639)
0.0	0.2	GO:0001562	response to protozoan(GO:0001562)
0.0	0.1	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.2	GO:0032814	regulation of natural killer cell activation(GO:0032814)
0.0	0.4	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.3	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.5	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.2	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0007343	egg activation(GO:0007343)
0.0	0.0	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.0	GO:0051132	NK T cell activation(GO:0051132)
0.0	0.1	GO:0060620	regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.0	0.1	GO:0051873	disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
0.0	0.1	GO:0032616	interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.0	0.1	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.1	GO:0071635	negative regulation of transforming growth factor beta production(GO:0071635)
0.0	0.1	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0	0.2	GO:0032367	intracellular sterol transport(GO:0032366) intracellular cholesterol transport(GO:0032367)
0.0	0.2	GO:0006265	DNA topological change(GO:0006265)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0030910	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.3	GO:0007512	adult heart development(GO:0007512)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.1	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.1	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.2	GO:0009253	peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0	0.0	GO:0002227	innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385)
0.0	0.4	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.0	GO:0097300	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.1	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:1901503	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.2	GO:0042355	fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.2	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.2	GO:0031529	ruffle organization(GO:0031529)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.2	GO:0051647	nucleus localization(GO:0051647)
0.0	0.1	GO:0014805	smooth muscle adaptation(GO:0014805)
0.0	0.2	GO:0042438	melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438)
0.0	0.2	GO:0030851	granulocyte differentiation(GO:0030851)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.0	GO:0042492	gamma-delta T cell differentiation(GO:0042492)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0010523	negative regulation of calcium ion transport into cytosol(GO:0010523)
0.0	0.1	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.1	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.1	GO:0002717	positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0	0.0	GO:0046532	regulation of photoreceptor cell differentiation(GO:0046532)
0.0	0.1	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)
0.0	0.1	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.1	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.1	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.2	GO:0000303	response to superoxide(GO:0000303)
0.0	0.1	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0	0.4	GO:0045576	mast cell activation(GO:0045576)
0.0	0.1	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.9	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.1	GO:0031442	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.0	GO:0050849	negative regulation of calcium-mediated signaling(GO:0050849)
0.0	0.1	GO:0048478	replication fork protection(GO:0048478)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0008291	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.0	GO:0001992	regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.1	GO:0070723	response to sterol(GO:0036314) response to cholesterol(GO:0070723)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.0	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.0	GO:0052251	induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0	0.0	GO:0090286	nuclear matrix organization(GO:0043578) cytoskeletal anchoring at nuclear membrane(GO:0090286) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0042119	granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0	0.0	GO:0051569	regulation of histone H3-K4 methylation(GO:0051569)
0.0	0.0	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.0	GO:0051447	negative regulation of meiotic cell cycle(GO:0051447)
0.0	0.1	GO:0032100	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.0	GO:0002251	organ or tissue specific immune response(GO:0002251)
0.0	0.1	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0045003	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.0	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.0	GO:0032971	regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.0	0.1	GO:0098927	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.1	GO:0009414	response to water deprivation(GO:0009414)
0.0	0.0	GO:0009822	alkaloid catabolic process(GO:0009822)
0.0	0.1	GO:0015853	adenine transport(GO:0015853)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089) positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) positive regulation of cell cycle G1/S phase transition(GO:1902808)
0.0	0.1	GO:0016199	axon midline choice point recognition(GO:0016199)
0.0	0.0	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.0	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.0	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.0	GO:0031063	regulation of histone deacetylation(GO:0031063) positive regulation of histone deacetylation(GO:0031065)
0.0	0.0	GO:0045579	positive regulation of B cell differentiation(GO:0045579)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.1	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.0	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.1	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.0	GO:0045423	regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.0	0.1	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0050798	activated T cell proliferation(GO:0050798)
0.0	0.1	GO:0010288	response to lead ion(GO:0010288)
0.0	0.0	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.1	GO:0033599	regulation of mammary gland epithelial cell proliferation(GO:0033599)
0.0	0.0	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.0	0.0	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0	0.2	GO:0070192	synapsis(GO:0007129) chromosome organization involved in meiotic cell cycle(GO:0070192)
0.0	0.0	GO:0043276	anoikis(GO:0043276)
0.0	0.0	GO:0060557	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.0	0.2	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.0	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.0	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.0	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.2	GO:0006906	vesicle fusion(GO:0006906)
0.0	0.0	GO:0010758	regulation of macrophage chemotaxis(GO:0010758)
0.0	0.0	GO:0045836	positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0009698	phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.0	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.0	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.2	GO:0007032	endosome organization(GO:0007032)
0.0	0.0	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0045349	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0	0.0	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:0002579	positive regulation of antigen processing and presentation(GO:0002579)
0.0	0.0	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.2	GO:0032088	negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0	0.1	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.0	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.0	GO:0046015	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0	0.0	GO:1903224	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.2	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.0	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.0	0.0	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0031648	protein destabilization(GO:0031648)
0.0	0.0	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.0	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.0	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0071459	protein localization to chromosome, centromeric region(GO:0071459)
0.0	0.0	GO:0097384	cellular lipid biosynthetic process(GO:0097384)
0.0	0.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.1	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.1	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.0	0.0	GO:0031058	positive regulation of histone modification(GO:0031058)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.0	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.0	GO:0002097	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.0	GO:0046549	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0	0.0	GO:0090382	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.0	GO:0051818	disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.0	0.1	GO:0090004	positive regulation of establishment of protein localization to plasma membrane(GO:0090004) positive regulation of protein localization to plasma membrane(GO:1903078) positive regulation of protein localization to cell periphery(GO:1904377)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546)
0.0	0.1	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)
0.0	0.0	GO:0060219	camera-type eye photoreceptor cell differentiation(GO:0060219)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1	0.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.2	GO:0031904	endosome lumen(GO:0031904)
0.1	0.2	GO:0005826	actomyosin contractile ring(GO:0005826)
0.1	0.2	GO:0000800	lateral element(GO:0000800)
0.0	0.3	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0002139	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.5	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.2	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.2	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.2	GO:0032040	small-subunit processome(GO:0032040)
0.0	0.1	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.2	GO:0033162	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.1	GO:0033011	perinuclear theca(GO:0033011)
0.0	0.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.0	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.4	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.1	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.2	GO:0001772	immunological synapse(GO:0001772)
0.0	0.8	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.2	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.0	GO:0032009	early phagosome(GO:0032009)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0042584	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	0.1	GO:0071817	MMXD complex(GO:0071817)
0.0	0.0	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.0	GO:0001652	granular component(GO:0001652)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.5	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.0	GO:0038201	TOR complex(GO:0038201)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.1	GO:0042597	outer membrane-bounded periplasmic space(GO:0030288) periplasmic space(GO:0042597)
0.0	0.1	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.0	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	0.1	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.4	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.1	GO:0061200	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.0	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.2	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.0	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.1	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	0.1	GO:0090576	RNA polymerase III transcription factor complex(GO:0090576)
0.0	0.0	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.1	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0004046	aminoacylase activity(GO:0004046)
0.1	0.3	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.1	0.3	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.2	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1	0.9	GO:0004697	protein kinase C activity(GO:0004697)
0.1	0.4	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.1	0.2	GO:0008518	reduced folate carrier activity(GO:0008518)
0.1	0.2	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.1	0.2	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.1	0.8	GO:0001637	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.1	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.3	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.2	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0042806	fucose binding(GO:0042806)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.2	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.1	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.2	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.3	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.3	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.2	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.5	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.5	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.5	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.4	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.0	GO:0032552	deoxyribonucleotide binding(GO:0032552)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.1	GO:0004339	glucan 1,4-alpha-glucosidase activity(GO:0004339)
0.0	0.2	GO:0004568	chitinase activity(GO:0004568)
0.0	0.5	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.3	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	1.0	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.0	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0009922	fatty acid elongase activity(GO:0009922)
0.0	0.2	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.1	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.1	GO:0016997	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0	0.1	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0070735	protein-glycine ligase activity(GO:0070735)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	0.3	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.0	GO:0001848	complement binding(GO:0001848)
0.0	0.3	GO:0022829	wide pore channel activity(GO:0022829)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.4	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.0	GO:0015205	nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.1	GO:0042923	neuropeptide binding(GO:0042923)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.0	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.0	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.2	GO:0004522	ribonuclease A activity(GO:0004522)
0.0	0.2	GO:0005542	folic acid binding(GO:0005542)
0.0	0.0	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.2	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.2	GO:0019534	toxin transporter activity(GO:0019534)
0.0	0.0	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.1	GO:0005497	androgen binding(GO:0005497)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.0	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0031210	phosphatidylcholine binding(GO:0031210)
0.0	0.0	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.0	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.0	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.0	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:0030553	cGMP binding(GO:0030553)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.0	GO:0004500	dopamine beta-monooxygenase activity(GO:0004500)
0.0	0.2	GO:0051117	ATPase binding(GO:0051117)
0.0	0.3	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	0.0	GO:0031014	troponin T binding(GO:0031014)
0.0	0.0	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.0	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.1	GO:0004448	isocitrate dehydrogenase activity(GO:0004448)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.0	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.1	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.0	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.0	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.0	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.1	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.3	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.0	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.0	GO:0016303	1-phosphatidylinositol-3-kinase activity(GO:0016303) phosphatidylinositol 3-kinase activity(GO:0035004)
0.0	0.0	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.0	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.0	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.0	GO:0010861	thyroid hormone receptor activator activity(GO:0010861)
0.0	0.0	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.0	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0	0.0	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.7	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.2	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
1.7	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.3	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.8	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
1.5	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.2	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.7	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.2	PID IL5 PATHWAY	IL5-mediated signaling events
0.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.3	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.3	PID BCR 5PATHWAY	BCR signaling pathway
0.2	PID IL2 1PATHWAY	IL2-mediated signaling events
0.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.2	PID EPO PATHWAY	EPO signaling pathway
0.8	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.7	PID IL4 2PATHWAY	IL4-mediated signaling events
0.3	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.2	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.2	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.1	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.1	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.2	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.0	PID IFNG PATHWAY	IFN-gamma pathway
0.0	PID S1P S1P1 PATHWAY	S1P1 pathway
0.1	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.2	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.2	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.2	PID ARF6 PATHWAY	Arf6 signaling events
0.2	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.1	0.3	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	0.8	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	1.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.9	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	1.1	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.5	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.3	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.1	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.0	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.2	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.2	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.0	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.3	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.0	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.4	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.4	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.0	0.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.8	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.3	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	0.2	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.1	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.0	0.3	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.3	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.1	REACTOME PIP3 ACTIVATES AKT SIGNALING	Genes involved in PIP3 activates AKT signaling
0.0	0.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.2	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.0	0.0	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.1	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.3	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.1	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.2	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.2	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.0	0.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.1	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	0.1	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.0	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.0	0.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.1	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.0	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.0	0.0	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression