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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for THRB

Z-value: 0.95

Motif logo

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Transcription factors associated with THRB

Gene Symbol Gene ID Gene Info
THRB
ENSG00000151090.13 thyroid hormone receptor beta

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr3_24193778_24193929THRB132330.292606-0.809.9e-03Click!
chr3_24283925_24284076THRB769140.1159630.771.4e-02Click!
chr3_24536950_24537123THRB2630.882887-0.722.8e-02Click!
chr3_24271931_24272082THRB649200.141320-0.655.6e-02Click!
chr3_24187341_24187492THRB196700.2735250.637.0e-02Click!

Activity of the THRB motif across conditions

Conditions sorted by the z-value of the THRB motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr12_123429411_123429620 1.03 ABCB9
 ATP-binding cassette, sub-family B (MDR/TAP), member 9
 293
 0.88
chr17_2869363_2869514 0.94 CTD-3060P21.1
249
 0.94
chr20_49983594_49983745 0.83 ENSG00000263645
 .
 10189
 0.28
chr17_70404089_70404240 0.76 ENSG00000200783
 .
 256127
 0.02
chr2_175307874_175308025 0.74 GPR155
 G protein-coupled receptor 155
 43816
 0.12
chr8_18991967_18992118 0.73 PSD3
 pleckstrin and Sec7 domain containing 3
 49802
 0.18
chr2_228735932_228736236 0.68 DAW1
 dynein assembly factor with WDR repeat domains 1
 239
 0.94
chr17_77023771_77023922 0.67 C1QTNF1-AS1
 C1QTNF1 antisense RNA 1
 109
 0.95
chr2_36635278_36635429 0.64 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 51739
 0.16
chr1_27864005_27864199 0.64 RP1-159A19.4
11786
 0.17
chr8_30656188_30656339 0.63 PPP2CB
 protein phosphatase 2, catalytic subunit, beta isozyme
 4466
 0.26
chr1_86021034_86021185 0.62 DDAH1
 dimethylarginine dimethylaminohydrolase 1
 22824
 0.17
chr17_58966579_58966730 0.61 BCAS3
 breast carcinoma amplified sequence 3
 2014
 0.33
chr5_52655964_52656115 0.61 FST
 follistatin
 120200
 0.06
chr1_7531258_7531628 0.60 RP4-549F15.1
29829
 0.21
chr5_111017081_111017232 0.60 ENSG00000253057
 .
 38602
 0.16
chr12_76256655_76256806 0.59 ENSG00000243420
 .
 95180
 0.08
chr1_204141000_204141151 0.59 REN
 renin
 5610
 0.15
chr10_81915037_81915188 0.55 ANXA11
 annexin A11
 6656
 0.2
chr5_159339303_159339454 0.55 ADRA1B
 adrenoceptor alpha 1B
 4412
 0.31
chr15_68911339_68911490 0.55 CORO2B
 coronin, actin binding protein, 2B
 2535
 0.41
chr9_110816490_110816641 0.54 ENSG00000222459
 .
 135306
 0.05
chr16_81601760_81601924 0.54 CMIP
 c-Maf inducing protein
 72888
 0.12
chr8_22454417_22454792 0.54 C8orf58
 chromosome 8 open reading frame 58
 2510
 0.15
chr15_83223362_83223513 0.53 RP11-152F13.10
1245
 0.33
chr17_80846919_80847070 0.52 TBCD
 tubulin folding cofactor D
 3034
 0.26
chr21_30047800_30047951 0.52 ENSG00000251894
 .
 67655
 0.14
chr16_27419960_27420215 0.51 IL21R
 interleukin 21 receptor
 5664
 0.22
chr9_132399053_132399204 0.50 RP11-483H20.4
3627
 0.14
chr2_10592171_10592322 0.50 ODC1
 ornithine decarboxylase 1
 3616
 0.22
chr15_31653474_31653647 0.49 KLF13
 Kruppel-like factor 13
 4797
 0.34
chr16_12214413_12214696 0.49 SNX29
 sorting nexin 29
 9000
 0.18
chr9_110947632_110947783 0.48 ENSG00000222512
 .
 173502
 0.03
chr14_24111076_24111295 0.48 DHRS2
 dehydrogenase/reductase (SDR family) member 2
 2637
 0.24
chr1_218833924_218834075 0.48 ENSG00000212610
 .
 118758
 0.06
chr7_55123506_55123657 0.48 EGFR
 epidermal growth factor receptor
 36770
 0.22
chr7_157064029_157064180 0.47 ENSG00000266453
 .
 34383
 0.19
chr17_1639800_1639951 0.47 RP11-961A15.1
2004
 0.18
chr21_46432509_46432660 0.46 AP001579.1
 Uncharacterized protein
 60343
 0.07
chr1_236107074_236107261 0.46 ENSG00000206803
 .
 28452
 0.17
chr7_2548232_2548731 0.46 LFNG
 LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
 3682
 0.2
chr5_72672425_72672576 0.44 FOXD1
 forkhead box D1
 71852
 0.1
chr4_169408008_169408159 0.44 DDX60L
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
 6418
 0.2
chr11_10314214_10314808 0.43 SBF2
 SET binding factor 2
 1243
 0.42
chr10_92066348_92066499 0.43 ENSG00000222451
 .
 142706
 0.05
chr3_100058113_100058264 0.43 NIT2
 nitrilase family, member 2
 4533
 0.24
chr1_61914926_61915077 0.43 NFIA
 nuclear factor I/A
 42657
 0.21
chr17_48141828_48141980 0.42 ITGA3
 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
 6333
 0.14
chr15_67316146_67316685 0.42 SMAD3
 SMAD family member 3
 39686
 0.2
chr6_7671378_7671529 0.42 BMP6
 bone morphogenetic protein 6
 55577
 0.14
chr8_32775609_32775811 0.42 ENSG00000212407
 .
 6594
 0.33
chr5_149844207_149844358 0.41 RPS14
 ribosomal protein S14
 14963
 0.16
chr14_62030492_62030755 0.41 RP11-47I22.3
 Uncharacterized protein
 6691
 0.21
chr2_75292380_75292531 0.41 ENSG00000263909
 .
 25484
 0.21
chr3_20098327_20098803 0.41 KAT2B
 K(lysine) acetyltransferase 2B
 17050
 0.18
chr2_122015503_122015654 0.40 TFCP2L1
 transcription factor CP2-like 1
 27205
 0.25
chr12_52674373_52674524 0.40 RP11-845M18.7
1508
 0.22
chr7_214681_214832 0.40 AC145676.2
 Uncharacterized protein
 14801
 0.19
chr10_49904377_49904528 0.40 WDFY4
 WDFY family member 4
 11531
 0.22
chr22_20887761_20888231 0.40 MED15
 mediator complex subunit 15
 9434
 0.12
chr6_36644830_36645109 0.40 CDKN1A
 cyclin-dependent kinase inhibitor 1A (p21, Cip1)
 619
 0.65
chr22_36445355_36445635 0.40 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 21022
 0.24
chr1_226849410_226849624 0.39 ITPKB-IT1
 ITPKB intronic transcript 1 (non-protein coding)
 2146
 0.33
chr11_64427589_64427881 0.39 AP001092.4
13864
 0.15
chr6_169572510_169572661 0.39 XXyac-YX65C7_A.2
40764
 0.2
chr3_122486711_122486862 0.39 ENSG00000238480
 .
 17567
 0.17
chr17_45343433_45343839 0.39 ENSG00000238419
 .
 6850
 0.14
chr11_122052864_122053015 0.38 ENSG00000207994
 .
 29923
 0.15
chr1_169083123_169083274 0.38 ATP1B1
 ATPase, Na+/K+ transporting, beta 1 polypeptide
 3362
 0.23
chr3_189433263_189433414 0.38 TP63
 tumor protein p63
 74111
 0.12
chr11_2224293_2224574 0.38 ENSG00000265258
 .
 30140
 0.1
chr9_5839505_5839749 0.38 ERMP1
 endoplasmic reticulum metallopeptidase 1
 6510
 0.22
chr22_38749450_38749601 0.38 RP3-449O17.1
30576
 0.11
chr19_55899777_55900128 0.37 RPL28
 ribosomal protein L28
 2226
 0.12
chr12_26351604_26351755 0.37 SSPN
 sarcospan
 3073
 0.29
chr9_107816671_107816822 0.37 ENSG00000201583
 .
 42291
 0.19
chr4_148736144_148736295 0.37 ENSG00000240014
 .
 6142
 0.23
chr12_95189281_95189432 0.36 ENSG00000208038
 .
 38818
 0.2
chr12_112550183_112550334 0.36 NAA25
 N(alpha)-acetyltransferase 25, NatB auxiliary subunit
 3432
 0.18
chr1_114000056_114000207 0.36 MAGI3
 membrane associated guanylate kinase, WW and PDZ domain containing 3
 66520
 0.14
chr16_20952479_20952845 0.36 LYRM1
 LYR motif containing 1
 40236
 0.13
chr2_62881644_62881884 0.35 AC092155.4
7999
 0.23
chr12_66350099_66350285 0.35 RP11-366L20.3
7933
 0.21
chr15_91318037_91318188 0.35 ENSG00000200677
 .
 19570
 0.14
chr2_65543802_65543953 0.35 SPRED2
 sprouty-related, EVH1 domain containing 2
 18030
 0.23
chr12_6338368_6338538 0.35 ENSG00000202318
 .
 5168
 0.2
chr17_62317609_62317841 0.35 TEX2
 testis expressed 2
 9609
 0.22
chr4_170053647_170053798 0.35 RP11-327O17.2
69223
 0.11
chr11_12753644_12753795 0.35 TEAD1
 TEA domain family member 1 (SV40 transcriptional enhancer factor)
 12869
 0.26
chr14_103868479_103868639 0.35 MARK3
 MAP/microtubule affinity-regulating kinase 3
 15983
 0.16
chr7_121184730_121184881 0.35 ENSG00000221690
 .
 30003
 0.24
chr9_132249416_132249920 0.35 ENSG00000264298
 .
 8833
 0.22
chr14_92864210_92864675 0.34 SLC24A4
 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
 10281
 0.28
chr2_14773054_14773337 0.34 FAM84A
 family with sequence similarity 84, member A
 371
 0.88
chr5_112483190_112483341 0.34 MCC
 mutated in colorectal cancers
 87109
 0.09
chr18_3653050_3653341 0.34 RP11-874J12.4
215
 0.94
chr14_23308927_23309078 0.34 MMP14
 matrix metallopeptidase 14 (membrane-inserted)
 2481
 0.13
chr2_169378165_169378347 0.34 ENSG00000265694
 .
 61197
 0.1
chr1_234722064_234722215 0.34 ENSG00000212144
 .
 6882
 0.2
chr3_50606139_50606449 0.33 HEMK1
 HemK methyltransferase family member 1
 289
 0.82
chr3_185482052_185482385 0.33 ENSG00000265470
 .
 3474
 0.28
chr10_105610481_105610681 0.33 SH3PXD2A
 SH3 and PX domains 2A
 4583
 0.23
chr4_71875471_71875927 0.33 DCK
 deoxycytidine kinase
 16344
 0.25
chr9_35258666_35258853 0.33 UNC13B
 unc-13 homolog B (C. elegans)
 96658
 0.06
chr1_92202773_92202924 0.32 ENSG00000239794
 .
 92783
 0.08
chr8_32407810_32407961 0.32 NRG1
 neuregulin 1
 1640
 0.54
chr14_22693388_22693539 0.32 ENSG00000238634
 .
 82576
 0.09
chr9_132949422_132949573 0.32 NCS1
 neuronal calcium sensor 1
 13375
 0.21
chr9_22237739_22238051 0.32 CDKN2B-AS1
 CDKN2B antisense RNA 1
 124218
 0.06
chr11_61748663_61748814 0.32 AP003733.1
 Uncharacterized protein; cDNA FLJ36460 fis, clone THYMU2014801
 13285
 0.13
chr17_73872544_73873300 0.32 TRIM47
 tripartite motif containing 47
 423
 0.43
chr14_105145297_105145448 0.31 ENSG00000265291
 .
 1286
 0.36
chr1_218649534_218649685 0.31 C1orf143
 chromosome 1 open reading frame 143
 33829
 0.2
chr18_24127643_24127794 0.31 KCTD1
 potassium channel tetramerization domain containing 1
 636
 0.79
chr3_124879753_124879904 0.31 ENSG00000264986
 .
 9432
 0.2
chr2_173116908_173117059 0.31 ENSG00000238572
 .
 96135
 0.07
chr17_29014178_29014503 0.31 ENSG00000241631
 .
 15453
 0.16
chr22_30194899_30195349 0.31 ASCC2
 activating signal cointegrator 1 complex subunit 2
 2967
 0.2
chr13_40738441_40738592 0.30 ENSG00000207458
 .
 62448
 0.15
chr2_216769053_216769204 0.30 ENSG00000212055
 .
 25486
 0.24
chr4_174293358_174293974 0.30 SAP30
 Sin3A-associated protein, 30kDa
 1572
 0.28
chr13_49081098_49081249 0.30 RCBTB2
 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
 26040
 0.23
chr1_27667588_27668215 0.30 SYTL1
 synaptotagmin-like 1
 612
 0.61
chrX_31217215_31217366 0.30 DMD
 dystrophin
 7427
 0.31
chr17_77022601_77022884 0.30 C1QTNF1-AS1
 C1QTNF1 antisense RNA 1
 941
 0.36
chr22_30601714_30601935 0.30 RP3-438O4.4
1274
 0.36
chr8_97349873_97350371 0.30 ENSG00000199732
 .
 28572
 0.17
chr17_21197723_21197874 0.29 MAP2K3
 mitogen-activated protein kinase kinase 3
 6440
 0.2
chr9_130906009_130906346 0.29 LCN2
 lipocalin 2
 5173
 0.09
chr10_72016101_72016252 0.29 PPA1
 pyrophosphatase (inorganic) 1
 22993
 0.17
chr3_99255664_99255815 0.29 COL8A1
 collagen, type VIII, alpha 1
 101580
 0.08
chr5_151058528_151058679 0.29 CTB-113P19.1
2069
 0.25
chr5_64689733_64689884 0.29 ADAMTS6
 ADAM metallopeptidase with thrombospondin type 1 motif, 6
 79710
 0.1
chr2_237677199_237677457 0.28 ACKR3
 atypical chemokine receptor 3
 199044
 0.03
chr16_89666849_89667000 0.28 CPNE7
 copine VII
 4940
 0.12
chr3_172033208_172033359 0.28 AC092964.1
 Uncharacterized protein
 935
 0.62
chr11_106328094_106328245 0.28 RP11-680E19.1
193127
 0.03
chr1_234752857_234753272 0.28 IRF2BP2
 interferon regulatory factor 2 binding protein 2
 7793
 0.19
chr1_41162222_41162675 0.28 NFYC
 nuclear transcription factor Y, gamma
 4486
 0.17
chr22_23035689_23035840 0.28 IGLV3-24
 immunoglobulin lambda variable 3-24 (pseudogene)
 1160
 0.15
chr2_73248670_73248821 0.28 SFXN5
 sideroflexin 5
 50057
 0.13
chr11_131920807_131920958 0.28 RP11-697E14.2
66327
 0.14
chr11_72500407_72500904 0.28 STARD10
 StAR-related lipid transfer (START) domain containing 10
 3643
 0.14
chr19_58893310_58893806 0.28 ZNF837
 zinc finger protein 837
 1131
 0.22
chr21_29625341_29625492 0.27 ENSG00000251894
 .
 490114
 0.01
chr2_64979976_64980127 0.27 ENSG00000253082
 .
 23187
 0.19
chr17_1520967_1521246 0.27 ENSG00000238946
 .
 1517
 0.25
chr1_208358461_208358612 0.27 PLXNA2
 plexin A2
 59129
 0.17
chr2_29337664_29337897 0.27 CLIP4
 CAP-GLY domain containing linker protein family, member 4
 512
 0.76
chrX_34919614_34919765 0.27 FAM47B
 family with sequence similarity 47, member B
 41224
 0.22
chr4_2802460_2802681 0.27 SH3BP2
 SH3-domain binding protein 2
 1845
 0.36
chr5_106695662_106695882 0.27 EFNA5
 ephrin-A5
 310556
 0.01
chr21_39648260_39648411 0.27 KCNJ15
 potassium inwardly-rectifying channel, subfamily J, member 15
 3906
 0.33
chr5_142885689_142885840 0.27 ENSG00000253023
 .
 36388
 0.19
chr9_119713049_119713301 0.27 ENSG00000265662
 .
 148111
 0.04
chr17_78644745_78644896 0.26 RPTOR
 regulatory associated protein of MTOR, complex 1
 125552
 0.05
chr14_73268075_73268226 0.26 ENSG00000206751
 .
 51889
 0.14
chr13_40810218_40810369 0.26 ENSG00000207458
 .
 9329
 0.31
chr3_72536153_72536343 0.26 RYBP
 RING1 and YY1 binding protein
 40179
 0.18
chr2_74810778_74811272 0.26 LOXL3
 lysyl oxidase-like 3
 28208
 0.08
chr11_106269511_106269662 0.26 RP11-680E19.1
134544
 0.05
chr1_224920982_224921133 0.26 RP11-3L21.2
2693
 0.27
chr5_95630524_95630804 0.26 ENSG00000206997
 .
 84733
 0.09
chr11_87064154_87064305 0.26 ENSG00000223015
 .
 253446
 0.02
chr15_85457860_85458027 0.25 ENSG00000207037
 .
 23810
 0.13
chrX_154297234_154297385 0.25 MTCP1
 mature T-cell proliferation 1
 2192
 0.2
chr4_38077270_38077549 0.25 TBC1D1
 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
 29917
 0.24
chr11_12147970_12148167 0.25 MICAL2
 microtubule associated monooxygenase, calponin and LIM domain containing 2
 5046
 0.31
chr1_12483776_12483927 0.25 VPS13D
 vacuolar protein sorting 13 homolog D (S. cerevisiae)
 13927
 0.23
chr15_41058349_41058500 0.25 GCHFR
 GTP cyclohydrolase I feedback regulator
 606
 0.58
chr11_68351182_68351333 0.25 PPP6R3
 protein phosphatase 6, regulatory subunit 3
 25147
 0.17
chr20_48760575_48761068 0.25 TMEM189-UBE2V1
 TMEM189-UBE2V1 readthrough
 9353
 0.17
chr7_105410894_105411045 0.25 ATXN7L1
 ataxin 7-like 1
 78885
 0.11
chr5_71762160_71762360 0.25 RP11-389C8.2
24046
 0.21
chr3_126340455_126340606 0.25 TXNRD3
 thioredoxin reductase 3
 12442
 0.17
chr14_100222322_100222621 0.25 EML1
 echinoderm microtubule associated protein like 1
 16815
 0.21
chr8_117049888_117050039 0.24 ENSG00000199450
 .
 14959
 0.29
chr1_109704266_109704907 0.24 ENSG00000238310
 .
 45884
 0.08
chr19_3434582_3434733 0.24 C19orf77
 chromosome 19 open reading frame 77
 43829
 0.09
chr3_184300499_184300650 0.24 EPHB3
 EPH receptor B3
 21002
 0.18
chr19_1365463_1365614 0.24 MUM1
 melanoma associated antigen (mutated) 1
 9175
 0.08
chr2_201391804_201392087 0.24 SGOL2
 shugoshin-like 2 (S. pombe)
 1055
 0.54
chr11_5617899_5618367 0.24 TRIM6
 tripartite motif containing 6
 97
 0.61
chr12_27717712_27717863 0.24 PPFIBP1
 PTPRF interacting protein, binding protein 1 (liprin beta 1)
 26731
 0.2
chr4_69138479_69138630 0.24 TMPRSS11B
 transmembrane protease, serine 11B
 27116
 0.16
chr2_238223705_238223856 0.23 AC112715.2
 Uncharacterized protein
 58046
 0.13
chr10_69848135_69848286 0.23 HERC4
 HECT and RLD domain containing E3 ubiquitin protein ligase 4
 13105
 0.18
chr9_21027016_21027377 0.23 PTPLAD2
 protein tyrosine phosphatase-like A domain containing 2
 4412
 0.24
chr20_25003716_25003867 0.23 ACSS1
 acyl-CoA synthetase short-chain family member 1
 9517
 0.19
chr22_36723096_36723607 0.23 ENSG00000266345
 .
 11105
 0.19
chr4_129746477_129746767 0.23 JADE1
 jade family PHD finger 1
 5966
 0.31
chr9_131655343_131655643 0.23 LRRC8A
 leucine rich repeat containing 8 family, member A
 10712
 0.11
chr4_88950180_88950331 0.23 PKD2
 polycystic kidney disease 2 (autosomal dominant)
 14158
 0.19
chr17_18904649_18904946 0.23 FAM83G
 family with sequence similarity 83, member G
 2692
 0.18
chr17_46662373_46662833 0.23 HOXB3
 homeobox B3
 2619
 0.1
chr15_52371258_52371409 0.23 CTD-2184D3.5
21387
 0.13
chr11_1580523_1580674 0.22 DUSP8
 dual specificity phosphatase 8
 6568
 0.13
chr7_55141300_55141512 0.22 EGFR
 epidermal growth factor receptor
 36010
 0.22
chr4_187622907_187623058 0.22 FAT1
 FAT atypical cadherin 1
 22027
 0.25
chr17_7344055_7344232 0.22 FGF11
 fibroblast growth factor 11
 81
 0.89

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of THRB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0001916 positive regulation of T cell mediated cytotoxicity(GO:0001916)
0.1 0.2 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.1 0.3 GO:0090400 stress-induced premature senescence(GO:0090400)
0.1 0.2 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.2 GO:0032431 activation of phospholipase A2 activity(GO:0032431)
0.0 0.0 GO:0051140 regulation of NK T cell activation(GO:0051133) positive regulation of NK T cell activation(GO:0051135) regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0 0.2 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 0.1 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.1 GO:0032048 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0 0.1 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.1 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.2 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.1 GO:0090030 regulation of steroid hormone biosynthetic process(GO:0090030)
0.0 0.1 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.0 GO:1903170 negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0 0.1 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.1 GO:0032495 response to muramyl dipeptide(GO:0032495)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.2 GO:0051567 histone H3-K9 methylation(GO:0051567) histone H3-K9 modification(GO:0061647)
0.0 0.1 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.0 GO:0051571 positive regulation of histone methylation(GO:0031062) positive regulation of histone H3-K4 methylation(GO:0051571)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.0 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466)
0.0 0.0 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.0 0.1 GO:0071800 podosome assembly(GO:0071800)
0.0 0.1 GO:1900078 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.0 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.0 GO:0061072 iris morphogenesis(GO:0061072)
0.0 0.0 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.1 GO:0060177 regulation of angiotensin levels in blood(GO:0002002) regulation of angiotensin metabolic process(GO:0060177)
0.0 0.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0 0.0 GO:0016115 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.0 GO:0045341 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.1 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0009120 deoxyribonucleoside metabolic process(GO:0009120)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0000052 citrulline metabolic process(GO:0000052)
0.0 0.0 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.1 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0 0.1 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.0 GO:0051138 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.1 GO:0042635 positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798)
0.0 0.1 GO:0031529 ruffle organization(GO:0031529)
0.0 0.1 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.1 GO:0043011 myeloid dendritic cell differentiation(GO:0043011) dendritic cell differentiation(GO:0097028)
0.0 0.1 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.0 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448)
0.0 0.0 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.0 GO:0072048 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0 0.0 GO:0000966 RNA 5'-end processing(GO:0000966)
0.0 0.0 GO:0006824 cobalt ion transport(GO:0006824)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.0 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.1 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 0.2 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.1 GO:1901222 activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0 0.0 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.0 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0042825 TAP complex(GO:0042825)
0.1 0.2 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.2 GO:0030128 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.2 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.1 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 0.0 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.2 GO:0030897 HOPS complex(GO:0030897)
0.0 0.2 GO:0008278 cohesin complex(GO:0008278)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.0 GO:0000800 lateral element(GO:0000800)
0.0 0.0 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.0 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.0 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.0 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0046980 tapasin binding(GO:0046980)
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 0.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.2 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.2 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.0 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.1 GO:0017166 vinculin binding(GO:0017166)
0.0 0.0 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.2 GO:0060590 ATPase regulator activity(GO:0060590)
0.0 0.2 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.0 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.0 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.0 GO:0043559 insulin binding(GO:0043559)
0.0 0.0 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.0 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.0 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.0 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.0 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.1 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.0 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.1 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.0 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 0.0 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation