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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for THRB

Z-value: 0.95

Motif logo

Transcription factors associated with THRB

Gene Symbol	Gene ID	Gene Info
THRB Ensembl NCBI GeneCards UniProt	ENSG00000151090.13	THRB

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
THRB	chr3_24193778_24193929	13233	0.292606	-0.80	9.9e-03	Click!
THRB	chr3_24283925_24284076	76914	0.115963	0.77	1.4e-02	Click!
THRB	chr3_24536950_24537123	263	0.882887	-0.72	2.8e-02	Click!
THRB	chr3_24271931_24272082	64920	0.141320	-0.65	5.6e-02	Click!
THRB	chr3_24187341_24187492	19670	0.273525	0.63	7.0e-02	Click!

Activity of the THRB motif across conditions

Conditions sorted by the z-value of the THRB motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_123429411_123429620	1.03	ABCB9	ATP-binding cassette, sub-family B (MDR/TAP), member 9	293	0.88
chr17_2869363_2869514	0.94	CTD-3060P21.1		249	0.94
chr20_49983594_49983745	0.83	ENSG00000263645	.	10189	0.28
chr17_70404089_70404240	0.76	ENSG00000200783	.	256127	0.02
chr2_175307874_175308025	0.74	GPR155	G protein-coupled receptor 155	43816	0.12
chr8_18991967_18992118	0.73	PSD3	pleckstrin and Sec7 domain containing 3	49802	0.18
chr2_228735932_228736236	0.68	DAW1	dynein assembly factor with WDR repeat domains 1	239	0.94
chr17_77023771_77023922	0.67	C1QTNF1-AS1	C1QTNF1 antisense RNA 1	109	0.95
chr2_36635278_36635429	0.64	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	51739	0.16
chr1_27864005_27864199	0.64	RP1-159A19.4		11786	0.17
chr8_30656188_30656339	0.63	PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	4466	0.26
chr1_86021034_86021185	0.62	DDAH1	dimethylarginine dimethylaminohydrolase 1	22824	0.17
chr17_58966579_58966730	0.61	BCAS3	breast carcinoma amplified sequence 3	2014	0.33
chr5_52655964_52656115	0.61	FST	follistatin	120200	0.06
chr1_7531258_7531628	0.60	RP4-549F15.1		29829	0.21
chr5_111017081_111017232	0.60	ENSG00000253057	.	38602	0.16
chr12_76256655_76256806	0.59	ENSG00000243420	.	95180	0.08
chr1_204141000_204141151	0.59	REN	renin	5610	0.15
chr10_81915037_81915188	0.55	ANXA11	annexin A11	6656	0.2
chr5_159339303_159339454	0.55	ADRA1B	adrenoceptor alpha 1B	4412	0.31
chr15_68911339_68911490	0.55	CORO2B	coronin, actin binding protein, 2B	2535	0.41
chr9_110816490_110816641	0.54	ENSG00000222459	.	135306	0.05
chr16_81601760_81601924	0.54	CMIP	c-Maf inducing protein	72888	0.12
chr8_22454417_22454792	0.54	C8orf58	chromosome 8 open reading frame 58	2510	0.15
chr15_83223362_83223513	0.53	RP11-152F13.10		1245	0.33
chr17_80846919_80847070	0.52	TBCD	tubulin folding cofactor D	3034	0.26
chr21_30047800_30047951	0.52	ENSG00000251894	.	67655	0.14
chr16_27419960_27420215	0.51	IL21R	interleukin 21 receptor	5664	0.22
chr9_132399053_132399204	0.50	RP11-483H20.4		3627	0.14
chr2_10592171_10592322	0.50	ODC1	ornithine decarboxylase 1	3616	0.22
chr15_31653474_31653647	0.49	KLF13	Kruppel-like factor 13	4797	0.34
chr16_12214413_12214696	0.49	SNX29	sorting nexin 29	9000	0.18
chr9_110947632_110947783	0.48	ENSG00000222512	.	173502	0.03
chr14_24111076_24111295	0.48	DHRS2	dehydrogenase/reductase (SDR family) member 2	2637	0.24
chr1_218833924_218834075	0.48	ENSG00000212610	.	118758	0.06
chr7_55123506_55123657	0.48	EGFR	epidermal growth factor receptor	36770	0.22
chr7_157064029_157064180	0.47	ENSG00000266453	.	34383	0.19
chr17_1639800_1639951	0.47	RP11-961A15.1		2004	0.18
chr21_46432509_46432660	0.46	AP001579.1	Uncharacterized protein	60343	0.07
chr1_236107074_236107261	0.46	ENSG00000206803	.	28452	0.17
chr7_2548232_2548731	0.46	LFNG	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	3682	0.2
chr5_72672425_72672576	0.44	FOXD1	forkhead box D1	71852	0.1
chr4_169408008_169408159	0.44	DDX60L	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	6418	0.2
chr11_10314214_10314808	0.43	SBF2	SET binding factor 2	1243	0.42
chr10_92066348_92066499	0.43	ENSG00000222451	.	142706	0.05
chr3_100058113_100058264	0.43	NIT2	nitrilase family, member 2	4533	0.24
chr1_61914926_61915077	0.43	NFIA	nuclear factor I/A	42657	0.21
chr17_48141828_48141980	0.42	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	6333	0.14
chr15_67316146_67316685	0.42	SMAD3	SMAD family member 3	39686	0.2
chr6_7671378_7671529	0.42	BMP6	bone morphogenetic protein 6	55577	0.14
chr8_32775609_32775811	0.42	ENSG00000212407	.	6594	0.33
chr5_149844207_149844358	0.41	RPS14	ribosomal protein S14	14963	0.16
chr14_62030492_62030755	0.41	RP11-47I22.3	Uncharacterized protein	6691	0.21
chr2_75292380_75292531	0.41	ENSG00000263909	.	25484	0.21
chr3_20098327_20098803	0.41	KAT2B	K(lysine) acetyltransferase 2B	17050	0.18
chr2_122015503_122015654	0.40	TFCP2L1	transcription factor CP2-like 1	27205	0.25
chr12_52674373_52674524	0.40	RP11-845M18.7		1508	0.22
chr7_214681_214832	0.40	AC145676.2	Uncharacterized protein	14801	0.19
chr10_49904377_49904528	0.40	WDFY4	WDFY family member 4	11531	0.22
chr22_20887761_20888231	0.40	MED15	mediator complex subunit 15	9434	0.12
chr6_36644830_36645109	0.40	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	619	0.65
chr22_36445355_36445635	0.40	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	21022	0.24
chr1_226849410_226849624	0.39	ITPKB-IT1	ITPKB intronic transcript 1 (non-protein coding)	2146	0.33
chr11_64427589_64427881	0.39	AP001092.4		13864	0.15
chr6_169572510_169572661	0.39	XXyac-YX65C7_A.2		40764	0.2
chr3_122486711_122486862	0.39	ENSG00000238480	.	17567	0.17
chr17_45343433_45343839	0.39	ENSG00000238419	.	6850	0.14
chr11_122052864_122053015	0.38	ENSG00000207994	.	29923	0.15
chr1_169083123_169083274	0.38	ATP1B1	ATPase, Na+/K+ transporting, beta 1 polypeptide	3362	0.23
chr3_189433263_189433414	0.38	TP63	tumor protein p63	74111	0.12
chr11_2224293_2224574	0.38	ENSG00000265258	.	30140	0.1
chr9_5839505_5839749	0.38	ERMP1	endoplasmic reticulum metallopeptidase 1	6510	0.22
chr22_38749450_38749601	0.38	RP3-449O17.1		30576	0.11
chr19_55899777_55900128	0.37	RPL28	ribosomal protein L28	2226	0.12
chr12_26351604_26351755	0.37	SSPN	sarcospan	3073	0.29
chr9_107816671_107816822	0.37	ENSG00000201583	.	42291	0.19
chr4_148736144_148736295	0.37	ENSG00000240014	.	6142	0.23
chr12_95189281_95189432	0.36	ENSG00000208038	.	38818	0.2
chr12_112550183_112550334	0.36	NAA25	N(alpha)-acetyltransferase 25, NatB auxiliary subunit	3432	0.18
chr1_114000056_114000207	0.36	MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	66520	0.14
chr16_20952479_20952845	0.36	LYRM1	LYR motif containing 1	40236	0.13
chr2_62881644_62881884	0.35	AC092155.4		7999	0.23
chr12_66350099_66350285	0.35	RP11-366L20.3		7933	0.21
chr15_91318037_91318188	0.35	ENSG00000200677	.	19570	0.14
chr2_65543802_65543953	0.35	SPRED2	sprouty-related, EVH1 domain containing 2	18030	0.23
chr12_6338368_6338538	0.35	ENSG00000202318	.	5168	0.2
chr17_62317609_62317841	0.35	TEX2	testis expressed 2	9609	0.22
chr4_170053647_170053798	0.35	RP11-327O17.2		69223	0.11
chr11_12753644_12753795	0.35	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	12869	0.26
chr14_103868479_103868639	0.35	MARK3	MAP/microtubule affinity-regulating kinase 3	15983	0.16
chr7_121184730_121184881	0.35	ENSG00000221690	.	30003	0.24
chr9_132249416_132249920	0.35	ENSG00000264298	.	8833	0.22
chr14_92864210_92864675	0.34	SLC24A4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	10281	0.28
chr2_14773054_14773337	0.34	FAM84A	family with sequence similarity 84, member A	371	0.88
chr5_112483190_112483341	0.34	MCC	mutated in colorectal cancers	87109	0.09
chr18_3653050_3653341	0.34	RP11-874J12.4		215	0.94
chr14_23308927_23309078	0.34	MMP14	matrix metallopeptidase 14 (membrane-inserted)	2481	0.13
chr2_169378165_169378347	0.34	ENSG00000265694	.	61197	0.1
chr1_234722064_234722215	0.34	ENSG00000212144	.	6882	0.2
chr3_50606139_50606449	0.33	HEMK1	HemK methyltransferase family member 1	289	0.82
chr3_185482052_185482385	0.33	ENSG00000265470	.	3474	0.28
chr10_105610481_105610681	0.33	SH3PXD2A	SH3 and PX domains 2A	4583	0.23
chr4_71875471_71875927	0.33	DCK	deoxycytidine kinase	16344	0.25
chr9_35258666_35258853	0.33	UNC13B	unc-13 homolog B (C. elegans)	96658	0.06
chr1_92202773_92202924	0.32	ENSG00000239794	.	92783	0.08
chr8_32407810_32407961	0.32	NRG1	neuregulin 1	1640	0.54
chr14_22693388_22693539	0.32	ENSG00000238634	.	82576	0.09
chr9_132949422_132949573	0.32	NCS1	neuronal calcium sensor 1	13375	0.21
chr9_22237739_22238051	0.32	CDKN2B-AS1	CDKN2B antisense RNA 1	124218	0.06
chr11_61748663_61748814	0.32	AP003733.1	Uncharacterized protein; cDNA FLJ36460 fis, clone THYMU2014801	13285	0.13
chr17_73872544_73873300	0.32	TRIM47	tripartite motif containing 47	423	0.43
chr14_105145297_105145448	0.31	ENSG00000265291	.	1286	0.36
chr1_218649534_218649685	0.31	C1orf143	chromosome 1 open reading frame 143	33829	0.2
chr18_24127643_24127794	0.31	KCTD1	potassium channel tetramerization domain containing 1	636	0.79
chr3_124879753_124879904	0.31	ENSG00000264986	.	9432	0.2
chr2_173116908_173117059	0.31	ENSG00000238572	.	96135	0.07
chr17_29014178_29014503	0.31	ENSG00000241631	.	15453	0.16
chr22_30194899_30195349	0.31	ASCC2	activating signal cointegrator 1 complex subunit 2	2967	0.2
chr13_40738441_40738592	0.30	ENSG00000207458	.	62448	0.15
chr2_216769053_216769204	0.30	ENSG00000212055	.	25486	0.24
chr4_174293358_174293974	0.30	SAP30	Sin3A-associated protein, 30kDa	1572	0.28
chr13_49081098_49081249	0.30	RCBTB2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	26040	0.23
chr1_27667588_27668215	0.30	SYTL1	synaptotagmin-like 1	612	0.61
chrX_31217215_31217366	0.30	DMD	dystrophin	7427	0.31
chr17_77022601_77022884	0.30	C1QTNF1-AS1	C1QTNF1 antisense RNA 1	941	0.36
chr22_30601714_30601935	0.30	RP3-438O4.4		1274	0.36
chr8_97349873_97350371	0.30	ENSG00000199732	.	28572	0.17
chr17_21197723_21197874	0.29	MAP2K3	mitogen-activated protein kinase kinase 3	6440	0.2
chr9_130906009_130906346	0.29	LCN2	lipocalin 2	5173	0.09
chr10_72016101_72016252	0.29	PPA1	pyrophosphatase (inorganic) 1	22993	0.17
chr3_99255664_99255815	0.29	COL8A1	collagen, type VIII, alpha 1	101580	0.08
chr5_151058528_151058679	0.29	CTB-113P19.1		2069	0.25
chr5_64689733_64689884	0.29	ADAMTS6	ADAM metallopeptidase with thrombospondin type 1 motif, 6	79710	0.1
chr2_237677199_237677457	0.28	ACKR3	atypical chemokine receptor 3	199044	0.03
chr16_89666849_89667000	0.28	CPNE7	copine VII	4940	0.12
chr3_172033208_172033359	0.28	AC092964.1	Uncharacterized protein	935	0.62
chr11_106328094_106328245	0.28	RP11-680E19.1		193127	0.03
chr1_234752857_234753272	0.28	IRF2BP2	interferon regulatory factor 2 binding protein 2	7793	0.19
chr1_41162222_41162675	0.28	NFYC	nuclear transcription factor Y, gamma	4486	0.17
chr22_23035689_23035840	0.28	IGLV3-24	immunoglobulin lambda variable 3-24 (pseudogene)	1160	0.15
chr2_73248670_73248821	0.28	SFXN5	sideroflexin 5	50057	0.13
chr11_131920807_131920958	0.28	RP11-697E14.2		66327	0.14
chr11_72500407_72500904	0.28	STARD10	StAR-related lipid transfer (START) domain containing 10	3643	0.14
chr19_58893310_58893806	0.28	ZNF837	zinc finger protein 837	1131	0.22
chr21_29625341_29625492	0.27	ENSG00000251894	.	490114	0.01
chr2_64979976_64980127	0.27	ENSG00000253082	.	23187	0.19
chr17_1520967_1521246	0.27	ENSG00000238946	.	1517	0.25
chr1_208358461_208358612	0.27	PLXNA2	plexin A2	59129	0.17
chr2_29337664_29337897	0.27	CLIP4	CAP-GLY domain containing linker protein family, member 4	512	0.76
chrX_34919614_34919765	0.27	FAM47B	family with sequence similarity 47, member B	41224	0.22
chr4_2802460_2802681	0.27	SH3BP2	SH3-domain binding protein 2	1845	0.36
chr5_106695662_106695882	0.27	EFNA5	ephrin-A5	310556	0.01
chr21_39648260_39648411	0.27	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	3906	0.33
chr5_142885689_142885840	0.27	ENSG00000253023	.	36388	0.19
chr9_119713049_119713301	0.27	ENSG00000265662	.	148111	0.04
chr17_78644745_78644896	0.26	RPTOR	regulatory associated protein of MTOR, complex 1	125552	0.05
chr14_73268075_73268226	0.26	ENSG00000206751	.	51889	0.14
chr13_40810218_40810369	0.26	ENSG00000207458	.	9329	0.31
chr3_72536153_72536343	0.26	RYBP	RING1 and YY1 binding protein	40179	0.18
chr2_74810778_74811272	0.26	LOXL3	lysyl oxidase-like 3	28208	0.08
chr11_106269511_106269662	0.26	RP11-680E19.1		134544	0.05
chr1_224920982_224921133	0.26	RP11-3L21.2		2693	0.27
chr5_95630524_95630804	0.26	ENSG00000206997	.	84733	0.09
chr11_87064154_87064305	0.26	ENSG00000223015	.	253446	0.02
chr15_85457860_85458027	0.25	ENSG00000207037	.	23810	0.13
chrX_154297234_154297385	0.25	MTCP1	mature T-cell proliferation 1	2192	0.2
chr4_38077270_38077549	0.25	TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	29917	0.24
chr11_12147970_12148167	0.25	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	5046	0.31
chr1_12483776_12483927	0.25	VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)	13927	0.23
chr15_41058349_41058500	0.25	GCHFR	GTP cyclohydrolase I feedback regulator	606	0.58
chr11_68351182_68351333	0.25	PPP6R3	protein phosphatase 6, regulatory subunit 3	25147	0.17
chr20_48760575_48761068	0.25	TMEM189-UBE2V1	TMEM189-UBE2V1 readthrough	9353	0.17
chr7_105410894_105411045	0.25	ATXN7L1	ataxin 7-like 1	78885	0.11
chr5_71762160_71762360	0.25	RP11-389C8.2		24046	0.21
chr3_126340455_126340606	0.25	TXNRD3	thioredoxin reductase 3	12442	0.17
chr14_100222322_100222621	0.25	EML1	echinoderm microtubule associated protein like 1	16815	0.21
chr8_117049888_117050039	0.24	ENSG00000199450	.	14959	0.29
chr1_109704266_109704907	0.24	ENSG00000238310	.	45884	0.08
chr19_3434582_3434733	0.24	C19orf77	chromosome 19 open reading frame 77	43829	0.09
chr3_184300499_184300650	0.24	EPHB3	EPH receptor B3	21002	0.18
chr19_1365463_1365614	0.24	MUM1	melanoma associated antigen (mutated) 1	9175	0.08
chr2_201391804_201392087	0.24	SGOL2	shugoshin-like 2 (S. pombe)	1055	0.54
chr11_5617899_5618367	0.24	TRIM6	tripartite motif containing 6	97	0.61
chr12_27717712_27717863	0.24	PPFIBP1	PTPRF interacting protein, binding protein 1 (liprin beta 1)	26731	0.2
chr4_69138479_69138630	0.24	TMPRSS11B	transmembrane protease, serine 11B	27116	0.16
chr2_238223705_238223856	0.23	AC112715.2	Uncharacterized protein	58046	0.13
chr10_69848135_69848286	0.23	HERC4	HECT and RLD domain containing E3 ubiquitin protein ligase 4	13105	0.18
chr9_21027016_21027377	0.23	PTPLAD2	protein tyrosine phosphatase-like A domain containing 2	4412	0.24
chr20_25003716_25003867	0.23	ACSS1	acyl-CoA synthetase short-chain family member 1	9517	0.19
chr22_36723096_36723607	0.23	ENSG00000266345	.	11105	0.19
chr4_129746477_129746767	0.23	JADE1	jade family PHD finger 1	5966	0.31
chr9_131655343_131655643	0.23	LRRC8A	leucine rich repeat containing 8 family, member A	10712	0.11
chr4_88950180_88950331	0.23	PKD2	polycystic kidney disease 2 (autosomal dominant)	14158	0.19
chr17_18904649_18904946	0.23	FAM83G	family with sequence similarity 83, member G	2692	0.18
chr17_46662373_46662833	0.23	HOXB3	homeobox B3	2619	0.1
chr15_52371258_52371409	0.23	CTD-2184D3.5		21387	0.13
chr11_1580523_1580674	0.22	DUSP8	dual specificity phosphatase 8	6568	0.13
chr7_55141300_55141512	0.22	EGFR	epidermal growth factor receptor	36010	0.22
chr4_187622907_187623058	0.22	FAT1	FAT atypical cadherin 1	22027	0.25
chr17_7344055_7344232	0.22	FGF11	fibroblast growth factor 11	81	0.89

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of THRB

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0001916	positive regulation of T cell mediated cytotoxicity(GO:0001916)
0.1	0.2	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.1	0.3	GO:0090400	stress-induced premature senescence(GO:0090400)
0.1	0.2	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.2	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.0	0.0	GO:0051140	regulation of NK T cell activation(GO:0051133) positive regulation of NK T cell activation(GO:0051135) regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0	0.2	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.1	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.1	GO:0032048	phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0	0.1	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.2	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0090030	regulation of steroid hormone biosynthetic process(GO:0090030)
0.0	0.1	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:1903170	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.1	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.1	GO:0032495	response to muramyl dipeptide(GO:0032495)
0.0	0.1	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.2	GO:0051567	histone H3-K9 methylation(GO:0051567) histone H3-K9 modification(GO:0061647)
0.0	0.1	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.0	GO:0051571	positive regulation of histone methylation(GO:0031062) positive regulation of histone H3-K4 methylation(GO:0051571)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.0	GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466)
0.0	0.0	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.1	GO:0071800	podosome assembly(GO:0071800)
0.0	0.1	GO:1900078	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.0	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.0	GO:0061072	iris morphogenesis(GO:0061072)
0.0	0.0	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.1	GO:0060177	regulation of angiotensin levels in blood(GO:0002002) regulation of angiotensin metabolic process(GO:0060177)
0.0	0.1	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0	0.0	GO:0016115	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.0	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.1	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.1	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.0	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.1	GO:0048715	negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.0	GO:0051138	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.1	GO:0042635	positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798)
0.0	0.1	GO:0031529	ruffle organization(GO:0031529)
0.0	0.1	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.0	0.1	GO:0043011	myeloid dendritic cell differentiation(GO:0043011) dendritic cell differentiation(GO:0097028)
0.0	0.1	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.0	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.0	GO:0072048	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0	0.0	GO:0000966	RNA 5'-end processing(GO:0000966)
0.0	0.0	GO:0006824	cobalt ion transport(GO:0006824)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0006596	polyamine biosynthetic process(GO:0006596)
0.0	0.2	GO:0006305	DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0	0.1	GO:1901222	activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0	0.0	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0	0.0	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.9	GO:0042825	TAP complex(GO:0042825)
0.1	0.2	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.2	GO:0030128	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.2	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.1	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.1	GO:0002102	podosome(GO:0002102)
0.0	0.0	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.2	GO:0030897	HOPS complex(GO:0030897)
0.0	0.2	GO:0008278	cohesin complex(GO:0008278)
0.0	0.2	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	0.0	GO:0000800	lateral element(GO:0000800)
0.0	0.0	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.2	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.0	GO:0070552	BRISC complex(GO:0070552)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.0	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.0	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.2	GO:0005720	nuclear heterochromatin(GO:0005720)
0.0	0.1	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.9	GO:0046980	tapasin binding(GO:0046980)
0.1	0.2	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.2	GO:0050682	AF-2 domain binding(GO:0050682)
0.1	0.2	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.2	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.2	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.3	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.2	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.1	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.0	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.1	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.2	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.2	GO:0060590	ATPase regulator activity(GO:0060590)
0.0	0.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.0	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.0	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.1	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.0	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.0	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.0	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0016409	palmitoyltransferase activity(GO:0016409)
0.0	0.0	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.1	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.0	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation