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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for TP73

Z-value: 0.93

Motif logo

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Transcription factors associated with TP73

Gene Symbol Gene ID Gene Info
TP73
ENSG00000078900.10 tumor protein p73

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr1_3594845_3595177TP7339190.141799-0.751.9e-02Click!
chr1_3593861_3594210TP7348950.131181-0.655.7e-02Click!
chr1_3619704_3619855TP7351570.1284380.636.9e-02Click!
chr1_3593293_3593464TP7355520.126652-0.636.9e-02Click!
chr1_3619930_3620081TP7353830.1269350.571.1e-01Click!

Activity of the TP73 motif across conditions

Conditions sorted by the z-value of the TP73 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr13_109833240_109833391 0.53 MYO16-AS1
 MYO16 antisense RNA 1
 20516
 0.27
chr3_133920629_133920780 0.42 RYK
 receptor-like tyrosine kinase
 18827
 0.26
chr15_74486059_74486210 0.40 STRA6
 stimulated by retinoic acid 6
 4560
 0.14
chr3_11254129_11254425 0.37 HRH1
 histamine receptor H1
 13440
 0.26
chr1_156211867_156212112 0.37 BGLAP
 bone gamma-carboxyglutamate (gla) protein
 236
 0.85
chr15_75995798_75996054 0.36 CSPG4
 chondroitin sulfate proteoglycan 4
 9263
 0.1
chr6_37045515_37045666 0.36 COX6A1P2
 cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
 32983
 0.16
chr19_48991448_48991599 0.34 CYTH2
 cytohesin 2
 15914
 0.09
chr22_45949176_45949470 0.34 FBLN1
 fibulin 1
 34660
 0.15
chr15_78180472_78180634 0.33 CSPG4P13
 chondroitin sulfate proteoglycan 4 pseudogene 13
 6473
 0.16
chr22_43523288_43523514 0.33 MCAT
 malonyl CoA:ACP acyltransferase (mitochondrial)
 15569
 0.13
chr16_27590487_27590638 0.32 KIAA0556
 KIAA0556
 5334
 0.22
chr9_137270522_137271255 0.29 ENSG00000263897
 .
 369
 0.9
chr5_17187432_17187583 0.29 AC091878.1
29649
 0.14
chr1_19635741_19635892 0.29 AKR7A2
 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
 2585
 0.15
chr12_52540643_52541115 0.29 ENSG00000265804
 .
 33170
 0.09
chr16_8980256_8980407 0.29 RP11-77H9.6
17223
 0.12
chr5_73112011_73112162 0.28 ARHGEF28
 Rho guanine nucleotide exchange factor (GEF) 28
 2743
 0.28
chr9_125138658_125139005 0.28 PTGS1
 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
 1230
 0.35
chr15_90754517_90755171 0.28 SEMA4B
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
 10076
 0.12
chr22_18515057_18515208 0.28 MICAL3
 microtubule associated monooxygenase, calponin and LIM domain containing 3
 7807
 0.15
chr1_116325528_116325679 0.28 CASQ2
 calsequestrin 2 (cardiac muscle)
 14201
 0.24
chr14_103577690_103577872 0.27 EXOC3L4
 exocyst complex component 3-like 4
 3928
 0.19
chr10_99306823_99306974 0.27 ANKRD2
 ankyrin repeat domain 2 (stretch responsive muscle)
 25300
 0.1
chr1_153521085_153521570 0.27 S100A3
 S100 calcium binding protein A3
 275
 0.76
chr11_12792556_12792707 0.27 TEAD1
 TEA domain family member 1 (SV40 transcriptional enhancer factor)
 26043
 0.2
chr1_119822332_119822483 0.27 ENSG00000238679
 .
 20743
 0.2
chr12_52810052_52810346 0.27 RP11-1020M18.10
8835
 0.09
chr1_115873923_115874074 0.26 NGF
 nerve growth factor (beta polypeptide)
 6859
 0.27
chr15_83222576_83222727 0.26 RP11-152F13.10
2031
 0.21
chr6_33853805_33853956 0.26 MLN
 motilin
 82092
 0.08
chr9_73569352_73569503 0.26 TRPM3
 transient receptor potential cation channel, subfamily M, member 3
 85453
 0.1
chr17_2869063_2869214 0.26 CTD-3060P21.1
51
 0.98
chr1_39583247_39583398 0.25 ENSG00000206654
 .
 3393
 0.22
chr10_64214734_64214920 0.25 ZNF365
 zinc finger protein 365
 65380
 0.13
chr1_27731813_27732238 0.25 GPR3
 G protein-coupled receptor 3
 12877
 0.13
chr17_1903178_1903329 0.25 CTD-2545H1.2
4345
 0.12
chr6_52282219_52282494 0.25 EFHC1
 EF-hand domain (C-terminal) containing 1
 2750
 0.34
chr3_13555826_13555977 0.25 FBLN2
 fibulin 2
 17923
 0.18
chr9_130297629_130297780 0.24 FAM129B
 family with sequence similarity 129, member B
 33663
 0.12
chr9_71746394_71746545 0.24 TJP2
 tight junction protein 2
 10245
 0.26
chr9_137394449_137394849 0.24 RXRA
 retinoid X receptor, alpha
 96221
 0.07
chr3_50202328_50202494 0.24 SEMA3F
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
 5959
 0.12
chr5_131430060_131430455 0.24 ENSG00000253067
 .
 14498
 0.15
chr1_226005147_226005298 0.24 EPHX1
 epoxide hydrolase 1, microsomal (xenobiotic)
 7386
 0.15
chr1_17275358_17275509 0.24 CROCC
 ciliary rootlet coiled-coil, rootletin
 26183
 0.11
chr4_123752064_123752215 0.24 ENSG00000253069
 .
 3970
 0.22
chr10_99356089_99356377 0.24 HOGA1
 4-hydroxy-2-oxoglutarate aldolase 1
 3326
 0.16
chr5_176898443_176898858 0.24 DBN1
 drebrin 1
 1221
 0.28
chr3_139020761_139020923 0.24 MRPS22
 mitochondrial ribosomal protein S22
 42019
 0.13
chr3_48636800_48636990 0.24 COL7A1
 collagen, type VII, alpha 1
 4195
 0.11
chr20_33893224_33893375 0.24 FAM83C
 family with sequence similarity 83, member C
 13095
 0.1
chr7_157197915_157198509 0.24 DNAJB6
 DnaJ (Hsp40) homolog, subfamily B, member 6
 65697
 0.11
chr17_45353575_45353931 0.24 ENSG00000238419
 .
 16967
 0.13
chr14_105439124_105439578 0.24 AHNAK2
 AHNAK nucleoprotein 2
 5343
 0.17
chr2_43268497_43268648 0.23 ENSG00000207087
 .
 50060
 0.18
chr2_10276228_10276379 0.23 C2orf48
 chromosome 2 open reading frame 48
 5206
 0.14
chr15_90327580_90327731 0.23 MESP2
 mesoderm posterior 2 homolog (mouse)
 8066
 0.13
chr11_121802656_121802807 0.23 ENSG00000252556
 .
 72332
 0.12
chr16_4513814_4513965 0.23 NMRAL1
 NmrA-like family domain containing 1
 2286
 0.2
chr11_9384115_9384314 0.23 IPO7
 importin 7
 21955
 0.16
chr1_183261326_183261477 0.23 NMNAT2
 nicotinamide nucleotide adenylyltransferase 2
 12608
 0.26
chr4_25116416_25116567 0.23 SEPSECS
 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
 45529
 0.15
chr1_228338191_228338342 0.23 GJC2
 gap junction protein, gamma 2, 47kDa
 713
 0.51
chr8_124553954_124554105 0.23 FBXO32
 F-box protein 32
 583
 0.77
chr3_52140801_52140952 0.23 LINC00696
 long intergenic non-protein coding RNA 696
 43309
 0.09
chr14_105437154_105437305 0.23 AHNAK2
 AHNAK nucleoprotein 2
 7465
 0.16
chr7_41743932_41744200 0.22 AC005027.3
867
 0.51
chr17_19234995_19235146 0.22 RP11-135L13.4
4370
 0.13
chr4_128544405_128544987 0.22 INTU
 inturned planar cell polarity protein
 270
 0.95
chr20_4356829_4357115 0.22 ADRA1D
 adrenoceptor alpha 1D
 127251
 0.05
chr1_227963929_227964080 0.22 SNAP47
 synaptosomal-associated protein, 47kDa
 28240
 0.14
chr1_244088089_244088421 0.22 AKT3
 v-akt murine thymoma viral oncogene homolog 3
 73874
 0.11
chr5_148532192_148532343 0.22 ABLIM3
 actin binding LIM protein family, member 3
 10657
 0.19
chr7_105470298_105470449 0.22 ATXN7L1
 ataxin 7-like 1
 46550
 0.18
chr17_27045400_27045747 0.22 RAB34
 RAB34, member RAS oncogene family
 126
 0.8
chr22_45949911_45950062 0.21 FBLN1
 fibulin 1
 35323
 0.15
chr20_2218141_2218292 0.21 TGM3
 transglutaminase 3
 58431
 0.12
chr14_21570539_21570690 0.21 ZNF219
 zinc finger protein 219
 1124
 0.27
chr19_47407880_47408230 0.21 ARHGAP35
 Rho GTPase activating protein 35
 13878
 0.17
chr1_11851239_11851390 0.21 C1orf167
 chromosome 1 open reading frame 167
 11440
 0.1
chr7_44224907_44225058 0.21 GCK
 glucokinase (hexokinase 4)
 3604
 0.16
chr8_41575514_41575665 0.21 ANK1
 ankyrin 1, erythrocytic
 11892
 0.18
chr13_114504859_114505144 0.21 GAS6-AS1
 GAS6 antisense RNA 1
 13602
 0.2
chr5_57537546_57537697 0.21 ENSG00000238899
 .
 171606
 0.03
chr7_30844366_30844720 0.21 AC004691.5
1517
 0.41
chr2_216613985_216614378 0.21 ENSG00000212055
 .
 129461
 0.05
chr17_13639928_13640079 0.21 ENSG00000236088
 .
 55864
 0.16
chr17_16767898_16768322 0.21 AC022596.2
12888
 0.13
chr1_201504197_201504388 0.21 CSRP1
 cysteine and glycine-rich protein 1
 25708
 0.14
chr15_74721479_74721779 0.20 SEMA7A
 semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
 4372
 0.17
chr15_63270206_63270357 0.20 TPM1
 tropomyosin 1 (alpha)
 64550
 0.1
chr5_136554415_136554566 0.20 SPOCK1
 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
 94737
 0.09
chr7_51114106_51114257 0.20 RP4-724E13.2
29021
 0.24
chr17_73805763_73805914 0.20 UNK
 unkempt family zinc finger
 9982
 0.09
chr18_20171274_20171425 0.20 ENSG00000206827
 .
 56196
 0.15
chr9_34253979_34254272 0.20 ENSG00000222426
 .
 28543
 0.11
chr8_103802696_103803356 0.20 ENSG00000266799
 .
 57079
 0.11
chr1_54666582_54666967 0.20 MRPL37
 mitochondrial ribosomal protein L37
 882
 0.39
chr12_52604840_52604991 0.20 KRT80
 keratin 80
 19131
 0.1
chr10_29760583_29760940 0.20 SVIL
 supervillin
 24686
 0.2
chr2_192251959_192252110 0.20 MYO1B
 myosin IB
 4826
 0.27
chr7_28076131_28076580 0.20 JAZF1
 JAZF zinc finger 1
 15937
 0.26
chr7_17372800_17372951 0.20 AC003075.4
33894
 0.17
chr19_33885180_33885411 0.19 CEBPG
 CCAAT/enhancer binding protein (C/EBP), gamma
 20077
 0.19
chr15_29570484_29570635 0.19 NDNL2
 necdin-like 2
 8526
 0.25
chr16_75290840_75291057 0.19 BCAR1
 breast cancer anti-estrogen resistance 1
 770
 0.56
chr1_156094375_156094823 0.19 LMNA
 lamin A/C
 1352
 0.29
chr12_57542255_57543089 0.19 RP11-545N8.3
1270
 0.29
chr2_27937945_27938621 0.19 AC074091.13
 Uncharacterized protein
 316
 0.86
chr7_137564480_137564636 0.19 DGKI
 diacylglycerol kinase, iota
 32720
 0.18
chr19_1168901_1169806 0.19 SBNO2
 strawberry notch homolog 2 (Drosophila)
 411
 0.76
chr12_3226263_3226517 0.19 TSPAN9-IT1
 TSPAN9 intronic transcript 1 (non-protein coding)
 32573
 0.17
chr13_51162602_51162753 0.19 DLEU7-AS1
 DLEU7 antisense RNA 1
 219315
 0.02
chr1_153572031_153572387 0.19 S100A16
 S100 calcium binding protein A16
 8589
 0.08
chr9_137516691_137516842 0.19 COL5A1
 collagen, type V, alpha 1
 16854
 0.2
chr2_39743971_39744122 0.19 AC007246.3
39
 0.98
chr8_124564532_124564683 0.19 FBXO32
 F-box protein 32
 11161
 0.19
chr22_36727795_36728637 0.19 ENSG00000266345
 .
 15970
 0.18
chr2_237771976_237772127 0.19 ENSG00000202341
 .
 151897
 0.04
chr1_156675699_156676565 0.19 CRABP2
 cellular retinoic acid binding protein 2
 524
 0.6
chr3_52039773_52040512 0.19 RPL29
 ribosomal protein L29
 10184
 0.09
chr2_206628931_206629328 0.19 AC007362.3
399
 0.9
chr18_20406433_20406706 0.19 RBBP8
 retinoblastoma binding protein 8
 28345
 0.16
chr3_25466068_25466219 0.19 RARB
 retinoic acid receptor, beta
 3611
 0.33
chr9_137222033_137222297 0.19 RXRA
 retinoid X receptor, alpha
 3739
 0.3
chr14_51909942_51910093 0.19 FRMD6
 FERM domain containing 6
 45838
 0.16
chr3_58192334_58192485 0.19 DNASE1L3
 deoxyribonuclease I-like 3
 1859
 0.34
chr16_65606309_65606460 0.19 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 450116
 0.01
chr4_189048820_189048971 0.19 ENSG00000201085
 .
 6107
 0.18
chr19_13107890_13108177 0.19 NFIX
 nuclear factor I/X (CCAAT-binding transcription factor)
 1381
 0.23
chr12_106502007_106502305 0.19 RP11-114F10.3
5215
 0.26
chr2_101728983_101729400 0.19 ENSG00000265860
 .
 19160
 0.19
chr18_46074651_46074802 0.19 CTIF
 CBP80/20-dependent translation initiation factor
 8260
 0.26
chr6_150590777_150590928 0.19 ENSG00000201628
 .
 57047
 0.13
chr5_52324020_52324171 0.19 CTD-2175A23.1
37987
 0.15
chr18_42834862_42835013 0.19 SLC14A2
 solute carrier family 14 (urea transporter), member 2
 41977
 0.19
chr5_139031059_139031535 0.19 CXXC5
 CXXC finger protein 5
 723
 0.71
chr15_40628103_40628665 0.19 C15orf52
 chromosome 15 open reading frame 52
 1857
 0.16
chr17_42665074_42665225 0.19 FZD2
 frizzled family receptor 2
 30224
 0.14
chr20_49983402_49983553 0.19 ENSG00000263645
 .
 10381
 0.28
chr4_129309482_129309633 0.19 PGRMC2
 progesterone receptor membrane component 2
 99573
 0.09
chr10_5594332_5594536 0.18 CALML3-AS1
 CALML3 antisense RNA 1
 26225
 0.13
chr9_95501833_95502258 0.18 BICD2
 bicaudal D homolog 2 (Drosophila)
 25049
 0.17
chr5_71506479_71506741 0.18 MAP1B
 microtubule-associated protein 1B
 31155
 0.18
chr19_48970127_48970278 0.18 CTC-273B12.5
8
 0.93
chr5_14181628_14181857 0.18 TRIO
 trio Rho guanine nucleotide exchange factor
 2165
 0.48
chr15_51520595_51520807 0.18 CYP19A1
 cytochrome P450, family 19, subfamily A, polypeptide 1
 13280
 0.18
chr18_60544137_60544288 0.18 PHLPP1
 PH domain and leucine rich repeat protein phosphatase 1
 26171
 0.18
chr19_30154923_30155074 0.18 PLEKHF1
 pleckstrin homology domain containing, family F (with FYVE domain) member 1
 965
 0.62
chr7_47334154_47334412 0.18 TNS3
 tensin 3
 14367
 0.31
chr4_141177970_141178121 0.18 SCOC
 short coiled-coil protein
 395
 0.88
chr1_16466515_16466919 0.18 RP11-276H7.2
14989
 0.11
chr11_44613969_44614120 0.18 CD82
 CD82 molecule
 4362
 0.23
chr15_70087017_70087168 0.18 ENSG00000215958
 .
 9249
 0.28
chr2_238407130_238407281 0.18 MLPH
 melanophilin
 11286
 0.19
chrX_45211105_45211256 0.18 RP11-342D14.1
31477
 0.25
chr7_47560263_47560414 0.18 TNS3
 tensin 3
 18537
 0.28
chr22_50741961_50742432 0.18 PLXNB2
 plexin B2
 2305
 0.15
chr17_43205364_43205515 0.18 PLCD3
 phospholipase C, delta 3
 4452
 0.12
chr17_75282058_75282603 0.18 SEPT9
 septin 9
 1643
 0.44
chr1_245986181_245986332 0.18 RP11-522M21.3
146476
 0.04
chr1_227161852_227162199 0.18 ADCK3
 aarF domain containing kinase 3
 8643
 0.21
chr3_185432797_185433008 0.18 C3orf65
 chromosome 3 open reading frame 65
 1822
 0.42
chr14_34155007_34155158 0.18 NPAS3
 neuronal PAS domain protein 3
 49365
 0.19
chr1_17880750_17880901 0.18 ARHGEF10L
 Rho guanine nucleotide exchange factor (GEF) 10-like
 14495
 0.24
chr3_87027489_87027640 0.18 VGLL3
 vestigial like 3 (Drosophila)
 12288
 0.31
chr11_12136448_12136727 0.18 MICAL2
 microtubule associated monooxygenase, calponin and LIM domain containing 2
 1656
 0.5
chr11_13140850_13141001 0.18 ENSG00000266625
 .
 155738
 0.04
chr7_126891938_126892869 0.18 GRM8
 glutamate receptor, metabotropic 8
 32
 0.98
chr2_237657369_237658039 0.18 ACKR3
 atypical chemokine receptor 3
 179420
 0.03
chr14_103984756_103984907 0.18 CKB
 creatine kinase, brain
 2607
 0.14
chr5_54896290_54897472 0.17 PPAP2A
 phosphatidic acid phosphatase type 2A
 66003
 0.11
chr16_73024351_73024526 0.17 ENSG00000221799
 .
 5682
 0.23
chr2_121372137_121372546 0.17 ENSG00000201006
 .
 36508
 0.21
chr17_75321642_75321958 0.17 SEPT9
 septin 9
 3108
 0.28
chr7_30839778_30839929 0.17 AC004691.5
3173
 0.25
chr5_67614932_67615223 0.17 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 26681
 0.26
chr1_206677916_206678151 0.17 RP11-534L20.5
752
 0.56
chr20_10055473_10055624 0.17 ENSG00000264599
 .
 18580
 0.2
chr1_16500642_16500847 0.17 RP11-276H7.3
14983
 0.1
chr9_137537253_137537404 0.17 COL5A1
 collagen, type V, alpha 1
 3708
 0.25
chr16_89233752_89233942 0.17 CDH15
 cadherin 15, type 1, M-cadherin (myotubule)
 4328
 0.15
chr17_16914497_16914878 0.17 MPRIP
 myosin phosphatase Rho interacting protein
 31172
 0.14
chr8_141600468_141600876 0.17 AGO2
 argonaute RISC catalytic component 2
 15315
 0.22
chr1_151283829_151283980 0.17 ENSG00000265753
 .
 10465
 0.09
chr19_45601288_45601848 0.17 PPP1R37
 protein phosphatase 1, regulatory subunit 37
 5136
 0.1
chr11_100590809_100590960 0.17 CTD-2383M3.1
32198
 0.17
chr18_33888908_33889059 0.17 FHOD3
 formin homology 2 domain containing 3
 11184
 0.27
chr10_17103416_17103567 0.17 CUBN
 cubilin (intrinsic factor-cobalamin receptor)
 66345
 0.12
chr11_73042897_73043053 0.17 ARHGEF17
 Rho guanine nucleotide exchange factor (GEF) 17
 20365
 0.12
chr16_53127962_53128318 0.17 CHD9
 chromodomain helicase DNA binding protein 9
 4932
 0.27
chr19_47128911_47129399 0.17 PTGIR
 prostaglandin I2 (prostacyclin) receptor (IP)
 780
 0.43
chr2_27238981_27239169 0.17 MAPRE3
 microtubule-associated protein, RP/EB family, member 3
 1408
 0.2
chr11_65257332_65257622 0.17 AP000769.1
 Uncharacterized protein
 34749
 0.08
chr12_7144086_7144237 0.17 LPCAT3
 lysophosphatidylcholine acyltransferase 3
 18347
 0.09
chr9_130336547_130336733 0.17 FAM129B
 family with sequence similarity 129, member B
 4628
 0.2
chr2_224966741_224966907 0.17 SERPINE2
 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
 62788
 0.13
chr9_91348798_91348949 0.17 ENSG00000265873
 .
 11947
 0.3
chr9_118395287_118395438 0.17 DEC1
 deleted in esophageal cancer 1
 491265
 0.0

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of TP73

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1 0.5 GO:0009629 response to gravity(GO:0009629)
0.0 0.1 GO:0035581 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0060057 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.2 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.1 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.1 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0 0.1 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.1 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.1 GO:0044256 multicellular organismal protein catabolic process(GO:0044254) protein digestion(GO:0044256) multicellular organismal macromolecule catabolic process(GO:0044266) multicellular organismal protein metabolic process(GO:0044268)
0.0 0.2 GO:0002281 macrophage activation involved in immune response(GO:0002281)
0.0 0.1 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.0 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.0 GO:0021801 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0 0.0 GO:2000649 regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.1 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.1 GO:0031223 auditory behavior(GO:0031223)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0015840 urea transport(GO:0015840)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0061117 negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0 0.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.1 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.0 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.2 GO:0043277 apoptotic cell clearance(GO:0043277)
0.0 0.1 GO:0046149 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.1 GO:0050917 sensory perception of umami taste(GO:0050917)
0.0 0.1 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.0 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.0 GO:0051580 regulation of neurotransmitter uptake(GO:0051580) regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940)
0.0 0.1 GO:0046902 regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559)
0.0 0.1 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.0 GO:0008215 spermine metabolic process(GO:0008215)
0.0 0.0 GO:0060913 cardiac cell fate determination(GO:0060913)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.0 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.1 GO:0006448 regulation of translational elongation(GO:0006448)
0.0 0.1 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.0 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 0.0 GO:0001973 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.0 GO:0048840 otolith development(GO:0048840)
0.0 0.0 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.1 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.1 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.1 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0 0.1 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.0 GO:0009732 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.3 GO:0048008 platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0 0.0 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.0 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.0 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.0 0.0 GO:0060014 granulosa cell differentiation(GO:0060014)
0.0 0.0 GO:0090047 obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0 0.0 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.0 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.0 0.0 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.0 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.0 0.3 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.1 GO:0019430 removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.0 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.0 0.0 GO:0009188 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0 0.0 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.0 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.0 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0032966 negative regulation of collagen biosynthetic process(GO:0032966)
0.0 0.0 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.1 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.0 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.1 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.0 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.0 GO:0048342 paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0 0.0 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.2 GO:0051350 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclase activity(GO:0031280) negative regulation of lyase activity(GO:0051350)
0.0 0.1 GO:0018200 peptidyl-glutamic acid modification(GO:0018200)
0.0 0.2 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.0 0.0 GO:0002326 B cell lineage commitment(GO:0002326)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 0.1 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0042599 lamellar body(GO:0042599)
0.0 0.1 GO:0043205 fibril(GO:0043205)
0.0 0.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.0 GO:0031045 dense core granule(GO:0031045)
0.0 0.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0046848 hydroxyapatite binding(GO:0046848)
0.1 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.2 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.1 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.0 0.2 GO:0098988 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.2 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.2 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.1 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.2 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0045159 myosin II binding(GO:0045159)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.0 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.0 GO:0004946 bombesin receptor activity(GO:0004946)
0.0 0.0 GO:0043734 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.0 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.1 GO:0051400 BH domain binding(GO:0051400)
0.0 0.0 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0019841 retinol binding(GO:0019841)
0.0 0.1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups(GO:0016725)
0.0 0.0 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.1 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.0 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.0 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.0 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.0 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.0 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.0 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.0 REACTOME GAB1 SIGNALOSOME Genes involved in GAB1 signalosome
0.0 0.1 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.1 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.0 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.0 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.2 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.0 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.0 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.0 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity