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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for TP73

Z-value: 0.93

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Transcription factors associated with TP73

Gene Symbol	Gene ID	Gene Info
TP73 Ensembl NCBI GeneCards UniProt	ENSG00000078900.10	TP73

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
TP73	chr1_3594845_3595177	3919	0.141799	-0.75	1.9e-02	Click!
TP73	chr1_3593861_3594210	4895	0.131181	-0.65	5.7e-02	Click!
TP73	chr1_3619704_3619855	5157	0.128438	0.63	6.9e-02	Click!
TP73	chr1_3593293_3593464	5552	0.126652	-0.63	6.9e-02	Click!
TP73	chr1_3619930_3620081	5383	0.126935	0.57	1.1e-01	Click!

Activity of the TP73 motif across conditions

Conditions sorted by the z-value of the TP73 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_109833240_109833391	0.53	MYO16-AS1	MYO16 antisense RNA 1	20516	0.27
chr3_133920629_133920780	0.42	RYK	receptor-like tyrosine kinase	18827	0.26
chr15_74486059_74486210	0.40	STRA6	stimulated by retinoic acid 6	4560	0.14
chr3_11254129_11254425	0.37	HRH1	histamine receptor H1	13440	0.26
chr1_156211867_156212112	0.37	BGLAP	bone gamma-carboxyglutamate (gla) protein	236	0.85
chr15_75995798_75996054	0.36	CSPG4	chondroitin sulfate proteoglycan 4	9263	0.1
chr6_37045515_37045666	0.36	COX6A1P2	cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2	32983	0.16
chr19_48991448_48991599	0.34	CYTH2	cytohesin 2	15914	0.09
chr22_45949176_45949470	0.34	FBLN1	fibulin 1	34660	0.15
chr15_78180472_78180634	0.33	CSPG4P13	chondroitin sulfate proteoglycan 4 pseudogene 13	6473	0.16
chr22_43523288_43523514	0.33	MCAT	malonyl CoA:ACP acyltransferase (mitochondrial)	15569	0.13
chr16_27590487_27590638	0.32	KIAA0556	KIAA0556	5334	0.22
chr9_137270522_137271255	0.29	ENSG00000263897	.	369	0.9
chr5_17187432_17187583	0.29	AC091878.1		29649	0.14
chr1_19635741_19635892	0.29	AKR7A2	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	2585	0.15
chr12_52540643_52541115	0.29	ENSG00000265804	.	33170	0.09
chr16_8980256_8980407	0.29	RP11-77H9.6		17223	0.12
chr5_73112011_73112162	0.28	ARHGEF28	Rho guanine nucleotide exchange factor (GEF) 28	2743	0.28
chr9_125138658_125139005	0.28	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	1230	0.35
chr15_90754517_90755171	0.28	SEMA4B	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B	10076	0.12
chr22_18515057_18515208	0.28	MICAL3	microtubule associated monooxygenase, calponin and LIM domain containing 3	7807	0.15
chr1_116325528_116325679	0.28	CASQ2	calsequestrin 2 (cardiac muscle)	14201	0.24
chr14_103577690_103577872	0.27	EXOC3L4	exocyst complex component 3-like 4	3928	0.19
chr10_99306823_99306974	0.27	ANKRD2	ankyrin repeat domain 2 (stretch responsive muscle)	25300	0.1
chr1_153521085_153521570	0.27	S100A3	S100 calcium binding protein A3	275	0.76
chr11_12792556_12792707	0.27	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	26043	0.2
chr1_119822332_119822483	0.27	ENSG00000238679	.	20743	0.2
chr12_52810052_52810346	0.27	RP11-1020M18.10		8835	0.09
chr1_115873923_115874074	0.26	NGF	nerve growth factor (beta polypeptide)	6859	0.27
chr15_83222576_83222727	0.26	RP11-152F13.10		2031	0.21
chr6_33853805_33853956	0.26	MLN	motilin	82092	0.08
chr9_73569352_73569503	0.26	TRPM3	transient receptor potential cation channel, subfamily M, member 3	85453	0.1
chr17_2869063_2869214	0.26	CTD-3060P21.1		51	0.98
chr1_39583247_39583398	0.25	ENSG00000206654	.	3393	0.22
chr10_64214734_64214920	0.25	ZNF365	zinc finger protein 365	65380	0.13
chr1_27731813_27732238	0.25	GPR3	G protein-coupled receptor 3	12877	0.13
chr17_1903178_1903329	0.25	CTD-2545H1.2		4345	0.12
chr6_52282219_52282494	0.25	EFHC1	EF-hand domain (C-terminal) containing 1	2750	0.34
chr3_13555826_13555977	0.25	FBLN2	fibulin 2	17923	0.18
chr9_130297629_130297780	0.24	FAM129B	family with sequence similarity 129, member B	33663	0.12
chr9_71746394_71746545	0.24	TJP2	tight junction protein 2	10245	0.26
chr9_137394449_137394849	0.24	RXRA	retinoid X receptor, alpha	96221	0.07
chr3_50202328_50202494	0.24	SEMA3F	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	5959	0.12
chr5_131430060_131430455	0.24	ENSG00000253067	.	14498	0.15
chr1_226005147_226005298	0.24	EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	7386	0.15
chr1_17275358_17275509	0.24	CROCC	ciliary rootlet coiled-coil, rootletin	26183	0.11
chr4_123752064_123752215	0.24	ENSG00000253069	.	3970	0.22
chr10_99356089_99356377	0.24	HOGA1	4-hydroxy-2-oxoglutarate aldolase 1	3326	0.16
chr5_176898443_176898858	0.24	DBN1	drebrin 1	1221	0.28
chr3_139020761_139020923	0.24	MRPS22	mitochondrial ribosomal protein S22	42019	0.13
chr3_48636800_48636990	0.24	COL7A1	collagen, type VII, alpha 1	4195	0.11
chr20_33893224_33893375	0.24	FAM83C	family with sequence similarity 83, member C	13095	0.1
chr7_157197915_157198509	0.24	DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	65697	0.11
chr17_45353575_45353931	0.24	ENSG00000238419	.	16967	0.13
chr14_105439124_105439578	0.24	AHNAK2	AHNAK nucleoprotein 2	5343	0.17
chr2_43268497_43268648	0.23	ENSG00000207087	.	50060	0.18
chr2_10276228_10276379	0.23	C2orf48	chromosome 2 open reading frame 48	5206	0.14
chr15_90327580_90327731	0.23	MESP2	mesoderm posterior 2 homolog (mouse)	8066	0.13
chr11_121802656_121802807	0.23	ENSG00000252556	.	72332	0.12
chr16_4513814_4513965	0.23	NMRAL1	NmrA-like family domain containing 1	2286	0.2
chr11_9384115_9384314	0.23	IPO7	importin 7	21955	0.16
chr1_183261326_183261477	0.23	NMNAT2	nicotinamide nucleotide adenylyltransferase 2	12608	0.26
chr4_25116416_25116567	0.23	SEPSECS	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	45529	0.15
chr1_228338191_228338342	0.23	GJC2	gap junction protein, gamma 2, 47kDa	713	0.51
chr8_124553954_124554105	0.23	FBXO32	F-box protein 32	583	0.77
chr3_52140801_52140952	0.23	LINC00696	long intergenic non-protein coding RNA 696	43309	0.09
chr14_105437154_105437305	0.23	AHNAK2	AHNAK nucleoprotein 2	7465	0.16
chr7_41743932_41744200	0.22	AC005027.3		867	0.51
chr17_19234995_19235146	0.22	RP11-135L13.4		4370	0.13
chr4_128544405_128544987	0.22	INTU	inturned planar cell polarity protein	270	0.95
chr20_4356829_4357115	0.22	ADRA1D	adrenoceptor alpha 1D	127251	0.05
chr1_227963929_227964080	0.22	SNAP47	synaptosomal-associated protein, 47kDa	28240	0.14
chr1_244088089_244088421	0.22	AKT3	v-akt murine thymoma viral oncogene homolog 3	73874	0.11
chr5_148532192_148532343	0.22	ABLIM3	actin binding LIM protein family, member 3	10657	0.19
chr7_105470298_105470449	0.22	ATXN7L1	ataxin 7-like 1	46550	0.18
chr17_27045400_27045747	0.22	RAB34	RAB34, member RAS oncogene family	126	0.8
chr22_45949911_45950062	0.21	FBLN1	fibulin 1	35323	0.15
chr20_2218141_2218292	0.21	TGM3	transglutaminase 3	58431	0.12
chr14_21570539_21570690	0.21	ZNF219	zinc finger protein 219	1124	0.27
chr19_47407880_47408230	0.21	ARHGAP35	Rho GTPase activating protein 35	13878	0.17
chr1_11851239_11851390	0.21	C1orf167	chromosome 1 open reading frame 167	11440	0.1
chr7_44224907_44225058	0.21	GCK	glucokinase (hexokinase 4)	3604	0.16
chr8_41575514_41575665	0.21	ANK1	ankyrin 1, erythrocytic	11892	0.18
chr13_114504859_114505144	0.21	GAS6-AS1	GAS6 antisense RNA 1	13602	0.2
chr5_57537546_57537697	0.21	ENSG00000238899	.	171606	0.03
chr7_30844366_30844720	0.21	AC004691.5		1517	0.41
chr2_216613985_216614378	0.21	ENSG00000212055	.	129461	0.05
chr17_13639928_13640079	0.21	ENSG00000236088	.	55864	0.16
chr17_16767898_16768322	0.21	AC022596.2		12888	0.13
chr1_201504197_201504388	0.21	CSRP1	cysteine and glycine-rich protein 1	25708	0.14
chr15_74721479_74721779	0.20	SEMA7A	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	4372	0.17
chr15_63270206_63270357	0.20	TPM1	tropomyosin 1 (alpha)	64550	0.1
chr5_136554415_136554566	0.20	SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	94737	0.09
chr7_51114106_51114257	0.20	RP4-724E13.2		29021	0.24
chr17_73805763_73805914	0.20	UNK	unkempt family zinc finger	9982	0.09
chr18_20171274_20171425	0.20	ENSG00000206827	.	56196	0.15
chr9_34253979_34254272	0.20	ENSG00000222426	.	28543	0.11
chr8_103802696_103803356	0.20	ENSG00000266799	.	57079	0.11
chr1_54666582_54666967	0.20	MRPL37	mitochondrial ribosomal protein L37	882	0.39
chr12_52604840_52604991	0.20	KRT80	keratin 80	19131	0.1
chr10_29760583_29760940	0.20	SVIL	supervillin	24686	0.2
chr2_192251959_192252110	0.20	MYO1B	myosin IB	4826	0.27
chr7_28076131_28076580	0.20	JAZF1	JAZF zinc finger 1	15937	0.26
chr7_17372800_17372951	0.20	AC003075.4		33894	0.17
chr19_33885180_33885411	0.19	CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	20077	0.19
chr15_29570484_29570635	0.19	NDNL2	necdin-like 2	8526	0.25
chr16_75290840_75291057	0.19	BCAR1	breast cancer anti-estrogen resistance 1	770	0.56
chr1_156094375_156094823	0.19	LMNA	lamin A/C	1352	0.29
chr12_57542255_57543089	0.19	RP11-545N8.3		1270	0.29
chr2_27937945_27938621	0.19	AC074091.13	Uncharacterized protein	316	0.86
chr7_137564480_137564636	0.19	DGKI	diacylglycerol kinase, iota	32720	0.18
chr19_1168901_1169806	0.19	SBNO2	strawberry notch homolog 2 (Drosophila)	411	0.76
chr12_3226263_3226517	0.19	TSPAN9-IT1	TSPAN9 intronic transcript 1 (non-protein coding)	32573	0.17
chr13_51162602_51162753	0.19	DLEU7-AS1	DLEU7 antisense RNA 1	219315	0.02
chr1_153572031_153572387	0.19	S100A16	S100 calcium binding protein A16	8589	0.08
chr9_137516691_137516842	0.19	COL5A1	collagen, type V, alpha 1	16854	0.2
chr2_39743971_39744122	0.19	AC007246.3		39	0.98
chr8_124564532_124564683	0.19	FBXO32	F-box protein 32	11161	0.19
chr22_36727795_36728637	0.19	ENSG00000266345	.	15970	0.18
chr2_237771976_237772127	0.19	ENSG00000202341	.	151897	0.04
chr1_156675699_156676565	0.19	CRABP2	cellular retinoic acid binding protein 2	524	0.6
chr3_52039773_52040512	0.19	RPL29	ribosomal protein L29	10184	0.09
chr2_206628931_206629328	0.19	AC007362.3		399	0.9
chr18_20406433_20406706	0.19	RBBP8	retinoblastoma binding protein 8	28345	0.16
chr3_25466068_25466219	0.19	RARB	retinoic acid receptor, beta	3611	0.33
chr9_137222033_137222297	0.19	RXRA	retinoid X receptor, alpha	3739	0.3
chr14_51909942_51910093	0.19	FRMD6	FERM domain containing 6	45838	0.16
chr3_58192334_58192485	0.19	DNASE1L3	deoxyribonuclease I-like 3	1859	0.34
chr16_65606309_65606460	0.19	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	450116	0.01
chr4_189048820_189048971	0.19	ENSG00000201085	.	6107	0.18
chr19_13107890_13108177	0.19	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	1381	0.23
chr12_106502007_106502305	0.19	RP11-114F10.3		5215	0.26
chr2_101728983_101729400	0.19	ENSG00000265860	.	19160	0.19
chr18_46074651_46074802	0.19	CTIF	CBP80/20-dependent translation initiation factor	8260	0.26
chr6_150590777_150590928	0.19	ENSG00000201628	.	57047	0.13
chr5_52324020_52324171	0.19	CTD-2175A23.1		37987	0.15
chr18_42834862_42835013	0.19	SLC14A2	solute carrier family 14 (urea transporter), member 2	41977	0.19
chr5_139031059_139031535	0.19	CXXC5	CXXC finger protein 5	723	0.71
chr15_40628103_40628665	0.19	C15orf52	chromosome 15 open reading frame 52	1857	0.16
chr17_42665074_42665225	0.19	FZD2	frizzled family receptor 2	30224	0.14
chr20_49983402_49983553	0.19	ENSG00000263645	.	10381	0.28
chr4_129309482_129309633	0.19	PGRMC2	progesterone receptor membrane component 2	99573	0.09
chr10_5594332_5594536	0.18	CALML3-AS1	CALML3 antisense RNA 1	26225	0.13
chr9_95501833_95502258	0.18	BICD2	bicaudal D homolog 2 (Drosophila)	25049	0.17
chr5_71506479_71506741	0.18	MAP1B	microtubule-associated protein 1B	31155	0.18
chr19_48970127_48970278	0.18	CTC-273B12.5		8	0.93
chr5_14181628_14181857	0.18	TRIO	trio Rho guanine nucleotide exchange factor	2165	0.48
chr15_51520595_51520807	0.18	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	13280	0.18
chr18_60544137_60544288	0.18	PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	26171	0.18
chr19_30154923_30155074	0.18	PLEKHF1	pleckstrin homology domain containing, family F (with FYVE domain) member 1	965	0.62
chr7_47334154_47334412	0.18	TNS3	tensin 3	14367	0.31
chr4_141177970_141178121	0.18	SCOC	short coiled-coil protein	395	0.88
chr1_16466515_16466919	0.18	RP11-276H7.2		14989	0.11
chr11_44613969_44614120	0.18	CD82	CD82 molecule	4362	0.23
chr15_70087017_70087168	0.18	ENSG00000215958	.	9249	0.28
chr2_238407130_238407281	0.18	MLPH	melanophilin	11286	0.19
chrX_45211105_45211256	0.18	RP11-342D14.1		31477	0.25
chr7_47560263_47560414	0.18	TNS3	tensin 3	18537	0.28
chr22_50741961_50742432	0.18	PLXNB2	plexin B2	2305	0.15
chr17_43205364_43205515	0.18	PLCD3	phospholipase C, delta 3	4452	0.12
chr17_75282058_75282603	0.18	SEPT9	septin 9	1643	0.44
chr1_245986181_245986332	0.18	RP11-522M21.3		146476	0.04
chr1_227161852_227162199	0.18	ADCK3	aarF domain containing kinase 3	8643	0.21
chr3_185432797_185433008	0.18	C3orf65	chromosome 3 open reading frame 65	1822	0.42
chr14_34155007_34155158	0.18	NPAS3	neuronal PAS domain protein 3	49365	0.19
chr1_17880750_17880901	0.18	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like	14495	0.24
chr3_87027489_87027640	0.18	VGLL3	vestigial like 3 (Drosophila)	12288	0.31
chr11_12136448_12136727	0.18	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	1656	0.5
chr11_13140850_13141001	0.18	ENSG00000266625	.	155738	0.04
chr7_126891938_126892869	0.18	GRM8	glutamate receptor, metabotropic 8	32	0.98
chr2_237657369_237658039	0.18	ACKR3	atypical chemokine receptor 3	179420	0.03
chr14_103984756_103984907	0.18	CKB	creatine kinase, brain	2607	0.14
chr5_54896290_54897472	0.17	PPAP2A	phosphatidic acid phosphatase type 2A	66003	0.11
chr16_73024351_73024526	0.17	ENSG00000221799	.	5682	0.23
chr2_121372137_121372546	0.17	ENSG00000201006	.	36508	0.21
chr17_75321642_75321958	0.17	SEPT9	septin 9	3108	0.28
chr7_30839778_30839929	0.17	AC004691.5		3173	0.25
chr5_67614932_67615223	0.17	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	26681	0.26
chr1_206677916_206678151	0.17	RP11-534L20.5		752	0.56
chr20_10055473_10055624	0.17	ENSG00000264599	.	18580	0.2
chr1_16500642_16500847	0.17	RP11-276H7.3		14983	0.1
chr9_137537253_137537404	0.17	COL5A1	collagen, type V, alpha 1	3708	0.25
chr16_89233752_89233942	0.17	CDH15	cadherin 15, type 1, M-cadherin (myotubule)	4328	0.15
chr17_16914497_16914878	0.17	MPRIP	myosin phosphatase Rho interacting protein	31172	0.14
chr8_141600468_141600876	0.17	AGO2	argonaute RISC catalytic component 2	15315	0.22
chr1_151283829_151283980	0.17	ENSG00000265753	.	10465	0.09
chr19_45601288_45601848	0.17	PPP1R37	protein phosphatase 1, regulatory subunit 37	5136	0.1
chr11_100590809_100590960	0.17	CTD-2383M3.1		32198	0.17
chr18_33888908_33889059	0.17	FHOD3	formin homology 2 domain containing 3	11184	0.27
chr10_17103416_17103567	0.17	CUBN	cubilin (intrinsic factor-cobalamin receptor)	66345	0.12
chr11_73042897_73043053	0.17	ARHGEF17	Rho guanine nucleotide exchange factor (GEF) 17	20365	0.12
chr16_53127962_53128318	0.17	CHD9	chromodomain helicase DNA binding protein 9	4932	0.27
chr19_47128911_47129399	0.17	PTGIR	prostaglandin I2 (prostacyclin) receptor (IP)	780	0.43
chr2_27238981_27239169	0.17	MAPRE3	microtubule-associated protein, RP/EB family, member 3	1408	0.2
chr11_65257332_65257622	0.17	AP000769.1	Uncharacterized protein	34749	0.08
chr12_7144086_7144237	0.17	LPCAT3	lysophosphatidylcholine acyltransferase 3	18347	0.09
chr9_130336547_130336733	0.17	FAM129B	family with sequence similarity 129, member B	4628	0.2
chr2_224966741_224966907	0.17	SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	62788	0.13
chr9_91348798_91348949	0.17	ENSG00000265873	.	11947	0.3
chr9_118395287_118395438	0.17	DEC1	deleted in esophageal cancer 1	491265	0.0

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TP73

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1	0.5	GO:0009629	response to gravity(GO:0009629)
0.0	0.1	GO:0035581	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0060057	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.2	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.1	GO:0044256	multicellular organismal protein catabolic process(GO:0044254) protein digestion(GO:0044256) multicellular organismal macromolecule catabolic process(GO:0044266) multicellular organismal protein metabolic process(GO:0044268)
0.0	0.2	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.0	0.1	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.1	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.1	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.0	0.0	GO:0021823	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.0	GO:0021801	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.0	GO:2000649	regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.1	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0031223	auditory behavior(GO:0031223)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0015840	urea transport(GO:0015840)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0061117	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.2	GO:0043277	apoptotic cell clearance(GO:0043277)
0.0	0.1	GO:0046149	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.1	GO:0050917	sensory perception of umami taste(GO:0050917)
0.0	0.1	GO:0043922	negative regulation by host of viral transcription(GO:0043922)
0.0	0.1	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.0	0.0	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.0	GO:0051580	regulation of neurotransmitter uptake(GO:0051580) regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940)
0.0	0.1	GO:0046902	regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559)
0.0	0.1	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.0	GO:0060913	cardiac cell fate determination(GO:0060913)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0021859	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.1	GO:0006448	regulation of translational elongation(GO:0006448)
0.0	0.1	GO:0035413	positive regulation of catenin import into nucleus(GO:0035413)
0.0	0.0	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.0	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.0	GO:0048840	otolith development(GO:0048840)
0.0	0.0	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0010700	negative regulation of norepinephrine secretion(GO:0010700)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0042219	cellular modified amino acid catabolic process(GO:0042219)
0.0	0.1	GO:0051898	negative regulation of protein kinase B signaling(GO:0051898)
0.0	0.1	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	0.1	GO:0006591	ornithine metabolic process(GO:0006591)
0.0	0.0	GO:0009732	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.3	GO:0048008	platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0	0.0	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.0	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0	0.0	GO:0072268	pattern specification involved in metanephros development(GO:0072268)
0.0	0.0	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.0	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.0	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.0	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.1	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.0	0.0	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.0	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.0	GO:0090280	positive regulation of calcium ion import(GO:0090280)
0.0	0.3	GO:0048286	lung alveolus development(GO:0048286)
0.0	0.1	GO:0019430	removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0	0.0	GO:0033591	response to L-ascorbic acid(GO:0033591)
0.0	0.0	GO:0009188	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.0	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.0	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.0	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.1	GO:0032966	negative regulation of collagen biosynthetic process(GO:0032966)
0.0	0.0	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.0	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.1	GO:0042797	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.0	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.0	GO:0048342	paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0	0.0	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.2	GO:0051350	negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclase activity(GO:0031280) negative regulation of lyase activity(GO:0051350)
0.0	0.1	GO:0018200	peptidyl-glutamic acid modification(GO:0018200)
0.0	0.2	GO:0042573	retinoic acid metabolic process(GO:0042573)
0.0	0.0	GO:0002326	B cell lineage commitment(GO:0002326)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	GO:0032593	insulin-responsive compartment(GO:0032593)
0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.1	GO:0002102	podosome(GO:0002102)
0.1	GO:0005593	FACIT collagen trimer(GO:0005593)
0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	GO:0042599	lamellar body(GO:0042599)
0.1	GO:0043205	fibril(GO:0043205)
0.1	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.1	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.3	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	GO:0031045	dense core granule(GO:0031045)
0.4	GO:0005791	rough endoplasmic reticulum(GO:0005791)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0046848	hydroxyapatite binding(GO:0046848)
0.1	0.2	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	0.2	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0004448	isocitrate dehydrogenase activity(GO:0004448)
0.0	0.2	GO:0098988	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.2	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.2	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.2	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0045159	myosin II binding(GO:0045159)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.0	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.1	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.0	GO:0004946	bombesin receptor activity(GO:0004946)
0.0	0.0	GO:0043734	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.0	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.0	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0019841	retinol binding(GO:0019841)
0.0	0.1	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0	0.1	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups(GO:0016725)
0.0	0.0	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.1	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0005112	Notch binding(GO:0005112)
0.0	0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.0	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.0	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.0	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.0	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.0	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.5	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.6	NABA COLLAGENS	Genes encoding collagen proteins
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.5	PID HES HEY PATHWAY	Notch-mediated HES/HEY network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	REACTOME GAB1 SIGNALOSOME	Genes involved in GAB1 signalosome
0.1	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.2	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.7	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.2	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity