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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for VAX2_RHOXF2

Z-value: 0.51

Motif logo

Transcription factors associated with VAX2_RHOXF2

Gene Symbol	Gene ID	Gene Info
VAX2 Ensembl NCBI GeneCards UniProt	ENSG00000116035.2	VAX2
RHOXF2 Ensembl NCBI GeneCards UniProt	ENSG00000131721.4	RHOXF2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
RHOXF2	chrX_119279296_119279447	13096	0.166420	0.72	3.0e-02	Click!
RHOXF2	chrX_119314962_119315113	22570	0.171382	-0.64	6.4e-02	Click!
RHOXF2	chrX_119314020_119314171	21628	0.173157	-0.63	6.8e-02	Click!
RHOXF2	chrX_119273447_119273598	18945	0.150548	-0.62	7.7e-02	Click!
RHOXF2	chrX_119290299_119290450	2093	0.309387	-0.20	6.0e-01	Click!
VAX2	chr2_71114393_71114674	13187	0.124127	0.73	2.7e-02	Click!
VAX2	chr2_71124315_71124466	3330	0.162954	0.61	7.9e-02	Click!
VAX2	chr2_71128195_71128714	734	0.548245	0.60	9.0e-02	Click!
VAX2	chr2_71115100_71115342	12499	0.124784	0.55	1.3e-01	Click!
VAX2	chr2_71116829_71116980	10816	0.126470	0.53	1.4e-01	Click!

Activity of the VAX2_RHOXF2 motif across conditions

Conditions sorted by the z-value of the VAX2_RHOXF2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr8_126941263_126941691	0.38	ENSG00000206695	.	28282	0.26
chr15_52802125_52802276	0.35	MYO5A	myosin VA (heavy chain 12, myoxin)	18838	0.2
chr14_98641364_98641616	0.33	ENSG00000222066	.	156597	0.04
chr17_47825562_47826034	0.32	FAM117A	family with sequence similarity 117, member A	15695	0.14
chr14_61812224_61812375	0.30	PRKCH	protein kinase C, eta	1257	0.5
chrX_11784442_11784722	0.29	MSL3	male-specific lethal 3 homolog (Drosophila)	6835	0.32
chr5_140934914_140935065	0.29	CTD-2024I7.13		2889	0.17
chr10_48508940_48509161	0.28	GDF10	growth differentiation factor 10	70074	0.1
chr1_169571123_169571274	0.28	F5	coagulation factor V (proaccelerin, labile factor)	15372	0.19
chr19_47948776_47948927	0.27	MEIS3	Meis homeobox 3	26071	0.11
chr14_98605614_98605900	0.27	C14orf64	chromosome 14 open reading frame 64	161296	0.04
chr4_153000457_153000739	0.27	ENSG00000253077	.	107833	0.07
chr3_121990121_121990409	0.27	ENSG00000221474	.	10435	0.16
chr11_9416407_9416558	0.27	IPO7	importin 7	10282	0.16
chr10_22899839_22899998	0.26	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	19276	0.27
chr17_14101706_14102107	0.26	AC005224.2		11899	0.2
chr15_60850340_60850622	0.26	CTD-2501E16.2		28309	0.16
chr3_56963223_56963374	0.26	ARHGEF3-AS1	ARHGEF3 antisense RNA 1	10770	0.22
chr2_43388712_43388910	0.26	ZFP36L2	ZFP36 ring finger protein-like 2	64937	0.11
chr6_158677695_158677913	0.25	TULP4	tubby like protein 4	55888	0.12
chr5_146138797_146138948	0.25	ENSG00000265875	.	24474	0.23
chr1_175157741_175158025	0.25	KIAA0040	KIAA0040	4007	0.31
chr2_122458404_122458555	0.24	ENSG00000238341	.	5154	0.2
chr15_85302679_85303048	0.24	RP11-7M10.2		6510	0.15
chr6_13686993_13687323	0.24	RANBP9	RAN binding protein 9	22	0.98
chr16_68502814_68502979	0.24	ENSG00000199263	.	5671	0.17
chr2_106545238_106545692	0.24	AC009505.2		71832	0.11
chr17_71720142_71720293	0.24	SDK2	sidekick cell adhesion molecule 2	79989	0.1
chr14_91858695_91858977	0.24	CCDC88C	coiled-coil domain containing 88C	24854	0.2
chr15_89170331_89170558	0.23	AEN	apoptosis enhancing nuclease	5843	0.16
chr11_30346022_30346188	0.23	ARL14EP	ADP-ribosylation factor-like 14 effector protein	1507	0.54
chr17_14094666_14094817	0.23	ENSG00000252305	.	14293	0.19
chr4_78749172_78749323	0.23	CNOT6L	CCR4-NOT transcription complex, subunit 6-like	8478	0.26
chr2_148056205_148056470	0.23	ENSG00000238860	.	25202	0.25
chr6_2893026_2893177	0.23	SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	10413	0.18
chr15_61011663_61011814	0.23	ENSG00000212625	.	17230	0.2
chr9_34662044_34662195	0.22	CCL27	chemokine (C-C motif) ligand 27	570	0.53
chr13_21121097_21121248	0.22	IFT88	intraflagellar transport 88 homolog (Chlamydomonas)	19413	0.18
chr11_117877070_117877221	0.22	IL10RA	interleukin 10 receptor, alpha	20036	0.16
chr10_64515756_64515907	0.22	ADO	2-aminoethanethiol (cysteamine) dioxygenase	48685	0.13
chr18_32701325_32701476	0.22	MAPRE2	microtubule-associated protein, RP/EB family, member 2	79786	0.1
chr5_75600048_75600202	0.22	RP11-466P24.6		7162	0.3
chr8_29412378_29412770	0.22	RP4-676L2.1		201887	0.02
chrX_118813796_118814051	0.21	SEPT6	septin 6	12869	0.17
chr1_27156953_27157104	0.21	ZDHHC18	zinc finger, DHHC-type containing 18	1467	0.28
chr14_99680375_99680629	0.21	AL109767.1		48783	0.14
chr12_66712818_66712969	0.21	HELB	helicase (DNA) B	16568	0.16
chr6_11357904_11358055	0.21	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	24553	0.24
chr17_65449492_65449678	0.21	ENSG00000244610	.	3821	0.17
chr11_65869578_65869729	0.21	PACS1	phosphofurin acidic cluster sorting protein 1	1419	0.28
chr1_235439552_235439703	0.21	GGPS1	geranylgeranyl diphosphate synthase 1	51038	0.11
chr5_156969848_156970007	0.21	AC106801.1		23045	0.14
chr6_159338511_159338747	0.21	ENSG00000223191	.	8974	0.2
chr3_3204987_3205138	0.21	RP11-97C16.1		10436	0.17
chr3_112193935_112194086	0.21	BTLA	B and T lymphocyte associated	24195	0.21
chr5_82767930_82768081	0.21	VCAN	versican	261	0.95
chr9_71643128_71643290	0.21	FXN	frataxin	6966	0.23
chr20_43628950_43629101	0.21	ENSG00000252021	.	3964	0.19
chr5_56129477_56129628	0.21	MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	18151	0.15
chr5_122851393_122851548	0.21	CSNK1G3	casein kinase 1, gamma 3	3516	0.28
chr11_44752503_44752654	0.21	TSPAN18	tetraspanin 18	3854	0.33
chr13_48886676_48886893	0.21	RB1	retinoblastoma 1	8873	0.27
chr3_16356148_16356299	0.20	RP11-415F23.2		277	0.9
chr6_108114469_108114620	0.20	SCML4	sex comb on midleg-like 4 (Drosophila)	21089	0.25
chr8_21823445_21823677	0.20	XPO7	exportin 7	188	0.94
chr7_21471999_21472183	0.20	SP4	Sp4 transcription factor	4430	0.22
chr5_75688534_75688866	0.20	IQGAP2	IQ motif containing GTPase activating protein 2	10374	0.28
chr16_74573386_74573537	0.20	GLG1	golgi glycoprotein 1	23762	0.19
chr14_68808631_68808789	0.20	RAD51B	RAD51 paralog B	69517	0.12
chr10_102996848_102997121	0.20	LBX1-AS1	LBX1 antisense RNA 1 (head to head)	711	0.61
chr5_118654433_118654664	0.20	ENSG00000243333	.	12222	0.19
chr1_167435126_167435452	0.20	RP11-104L21.2		7391	0.22
chr3_184274253_184274404	0.20	EIF2B5-AS1	EIF2B5 antisense RNA 1	378	0.86
chr19_36000408_36000843	0.20	DMKN	dermokine	488	0.65
chr2_109603249_109603400	0.20	EDAR	ectodysplasin A receptor	2401	0.41
chr5_130638723_130638874	0.20	CDC42SE2	CDC42 small effector 2	39005	0.21
chr11_128167606_128167864	0.20	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	207554	0.02
chr1_115041886_115042037	0.20	ENSG00000201114	.	8615	0.22
chr1_66712472_66712670	0.19	PDE4B	phosphodiesterase 4B, cAMP-specific	10759	0.3
chr4_78777778_78777929	0.19	MRPL1	mitochondrial ribosomal protein L1	5821	0.28
chr2_205942725_205942950	0.19	PARD3B	par-3 family cell polarity regulator beta	532114	0.0
chr7_128880488_128880639	0.19	AHCYL2	adenosylhomocysteinase-like 2	15672	0.16
chr5_112359168_112359319	0.19	DCP2	decapping mRNA 2	46764	0.15
chrX_20048047_20048247	0.19	ENSG00000264566	.	12842	0.17
chr6_117804732_117805043	0.19	DCBLD1	discoidin, CUB and LCCL domain containing 1	1062	0.49
chr4_123556022_123556173	0.19	IL21	interleukin 21	13873	0.21
chr12_838464_838718	0.19	WNK1	WNK lysine deficient protein kinase 1	23168	0.18
chr5_156636522_156636760	0.19	CTB-4E7.1		14749	0.12
chr1_167615092_167615243	0.19	RP3-455J7.4		15256	0.19
chr1_100844302_100844453	0.19	ENSG00000216067	.	46	0.98
chr7_6522910_6523061	0.19	FLJ20306	CDNA FLJ20306 fis, clone HEP06881; Putative uncharacterized protein FLJ20306; Uncharacterized protein	63	0.89
chr15_60865631_60865913	0.19	RORA	RAR-related orphan receptor A	18968	0.19
chr3_108566035_108566186	0.19	TRAT1	T cell receptor associated transmembrane adaptor 1	24491	0.23
chr16_74620197_74620348	0.19	GLG1	golgi glycoprotein 1	20720	0.2
chr6_647016_647167	0.19	HUS1B	HUS1 checkpoint homolog b (S. pombe)	9872	0.27
chr1_29490695_29490846	0.19	RP11-242O24.5		11769	0.16
chrX_39170629_39170782	0.19	ENSG00000207122	.	230167	0.02
chr3_112040032_112040183	0.19	CD200	CD200 molecule	11087	0.23
chr7_12254768_12254919	0.19	TMEM106B	transmembrane protein 106B	3894	0.37
chr12_10282940_10283100	0.19	CLEC7A	C-type lectin domain family 7, member A	164	0.93
chr17_33863325_33863476	0.19	SLFN12L	schlafen family member 12-like	1480	0.27
chr6_157109556_157109748	0.19	RP11-230C9.3		8063	0.2
chr20_34234716_34234867	0.19	ENSG00000252549	.	561	0.6
chr5_171611435_171611646	0.19	STK10	serine/threonine kinase 10	3850	0.23
chr2_15318659_15318819	0.18	NBAS	neuroblastoma amplified sequence	11782	0.32
chr2_166185054_166185205	0.18	SCN2A	sodium channel, voltage-gated, type II, alpha subunit	32846	0.22
chr12_12775741_12775989	0.18	CREBL2	cAMP responsive element binding protein-like 2	11039	0.2
chr16_4114751_4115046	0.18	RP11-462G12.4		32885	0.16
chr9_92032244_92032395	0.18	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	1429	0.51
chr10_4121743_4121894	0.18	KLF6	Kruppel-like factor 6	294345	0.01
chr17_33348954_33349130	0.18	RFFL	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	612	0.63
chr6_156720023_156720174	0.18	ENSG00000212295	.	20214	0.3
chr17_40700754_40700905	0.18	HSD17B1	hydroxysteroid (17-beta) dehydrogenase 1	403	0.66
chr18_60873699_60873977	0.18	ENSG00000238988	.	11940	0.23
chr3_184325833_184325984	0.18	EPHB3	EPH receptor B3	46336	0.13
chr6_119226723_119226983	0.18	ASF1A	anti-silencing function 1A histone chaperone	11469	0.19
chr14_52381180_52381331	0.18	GNG2	guanine nucleotide binding protein (G protein), gamma 2	1425	0.37
chr6_122733810_122733961	0.18	HSF2	heat shock transcription factor 2	9416	0.25
chr2_106522886_106523037	0.18	AC009505.2		49328	0.16
chr6_112020418_112020739	0.18	FYN	FYN oncogene related to SRC, FGR, YES	20687	0.21
chr6_135414750_135415028	0.18	HBS1L	HBS1-like (S. cerevisiae)	9305	0.22
chr10_8130727_8131157	0.17	GATA3	GATA binding protein 3	34173	0.24
chr14_53258584_53258855	0.17	GNPNAT1	glucosamine-phosphate N-acetyltransferase 1	333	0.86
chr20_57722289_57722440	0.17	ZNF831	zinc finger protein 831	43711	0.15
chr17_63031973_63032289	0.17	RP11-583F2.5		15896	0.16
chr3_42258092_42258243	0.17	ENSG00000222872	.	5165	0.23
chr14_92973076_92973375	0.17	RIN3	Ras and Rab interactor 3	6893	0.29
chr4_20916404_20916555	0.17	KCNIP4	Kv channel interacting protein 4	69153	0.13
chr3_32998308_32998459	0.17	CCR4	chemokine (C-C motif) receptor 4	5317	0.28
chr16_11346729_11346935	0.17	SOCS1	suppressor of cytokine signaling 1	3204	0.12
chr10_16877098_16877261	0.17	RSU1	Ras suppressor protein 1	17652	0.26
chr2_30557961_30558163	0.17	ENSG00000221377	.	97252	0.07
chr5_49991075_49991374	0.17	PARP8	poly (ADP-ribose) polymerase family, member 8	27833	0.27
chrY_7194717_7195015	0.17	ENSG00000252633	.	2230	0.31
chr7_25004547_25004698	0.17	OSBPL3	oxysterol binding protein-like 3	15138	0.26
chr5_64919668_64919819	0.17	TRIM23	tripartite motif containing 23	380	0.59
chr15_93372987_93373270	0.17	FAM174B	family with sequence similarity 174, member B	20100	0.15
chr10_30991700_30991887	0.17	SVILP1	supervillin pseudogene 1	6943	0.27
chr5_114715684_114715835	0.17	CCDC112	coiled-coil domain containing 112	83231	0.09
chr4_109022417_109022568	0.17	LEF1	lymphoid enhancer-binding factor 1	64965	0.11
chr2_158768231_158768382	0.17	ENSG00000251980	.	978	0.56
chr11_65107055_65107206	0.17	DPF2	D4, zinc and double PHD fingers family 2	5792	0.12
chr14_22535112_22535263	0.17	ENSG00000238634	.	75700	0.11
chr3_14467854_14468179	0.17	SLC6A6	solute carrier family 6 (neurotransmitter transporter), member 6	6162	0.25
chr13_42969980_42970150	0.17	AKAP11	A kinase (PRKA) anchor protein 11	123776	0.06
chr2_235395214_235395372	0.17	ARL4C	ADP-ribosylation factor-like 4C	9951	0.32
chr7_138768806_138768957	0.17	ZC3HAV1	zinc finger CCCH-type, antiviral 1	4868	0.24
chr5_55443907_55444286	0.17	ENSG00000223003	.	1423	0.42
chr8_121714189_121714356	0.17	RP11-713M15.1		59221	0.14
chr21_43810236_43810387	0.17	TMPRSS3	transmembrane protease, serine 3	5741	0.14
chr10_6087007_6087203	0.17	IL2RA	interleukin 2 receptor, alpha	17148	0.13
chr22_27066729_27066953	0.17	CRYBA4	crystallin, beta A4	48913	0.13
chr16_3865090_3865241	0.16	CREBBP	CREB binding protein	34297	0.17
chr5_118678786_118679078	0.16	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	10062	0.21
chr8_81976580_81976731	0.16	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	47648	0.18
chr22_40340974_40341233	0.16	GRAP2	GRB2-related adaptor protein 2	1718	0.34
chr6_133057981_133058132	0.16	VNN3	vanin 3	2152	0.22
chr2_63287841_63287992	0.16	OTX1	orthodenticle homeobox 1	9979	0.23
chr10_102989164_102989315	0.16	LBX1-AS1	LBX1 antisense RNA 1 (head to head)	112	0.75
chr17_8311463_8311614	0.16	NDEL1	nudE neurodevelopment protein 1-like 1	4911	0.12
chr6_35649971_35650157	0.16	FKBP5	FK506 binding protein 5	6628	0.14
chr1_155910079_155910230	0.16	RXFP4	relaxin/insulin-like family peptide receptor 4	1326	0.24
chr11_35020496_35020647	0.16	PDHX	pyruvate dehydrogenase complex, component X	21240	0.2
chr8_126930029_126930180	0.16	ENSG00000206695	.	16909	0.3
chr3_53072608_53072759	0.16	SFMBT1	Scm-like with four mbt domains 1	6598	0.19
chr12_58147924_58148156	0.16	MARCH9	membrane-associated ring finger (C3HC4) 9	841	0.29
chr18_67554931_67555082	0.16	CD226	CD226 molecule	59649	0.15
chr4_57687212_57687509	0.16	SPINK2	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)	500	0.74
chr8_27223358_27224128	0.16	PTK2B	protein tyrosine kinase 2 beta	14425	0.22
chr17_73374792_73374943	0.16	RP11-16C1.2		5050	0.11
chr6_149404447_149404642	0.16	RP11-162J8.3		50835	0.15
chr19_12442701_12443014	0.16	ZNF563	zinc finger protein 563	1449	0.33
chr6_44797257_44797514	0.16	SUPT3H	suppressor of Ty 3 homolog (S. cerevisiae)	125862	0.06
chr8_127567681_127568033	0.16	RP11-103H7.5		1284	0.38
chr13_41574006_41574157	0.16	ELF1	E74-like factor 1 (ets domain transcription factor)	17663	0.19
chr9_86303237_86303482	0.16	RP11-522I20.3		19150	0.17
chr1_226911013_226911201	0.16	ITPKB	inositol-trisphosphate 3-kinase B	14052	0.21
chr18_19178052_19178356	0.16	ESCO1	establishment of sister chromatid cohesion N-acetyltransferase 1	2493	0.23
chr12_111005224_111005381	0.16	PPTC7	PTC7 protein phosphatase homolog (S. cerevisiae)	15823	0.14
chr1_235014905_235015056	0.16	ENSG00000239690	.	24953	0.21
chr16_73092870_73093114	0.16	ZFHX3	zinc finger homeobox 3	605	0.79
chr4_38518191_38518342	0.16	RP11-617D20.1		107930	0.07
chr14_92322968_92323119	0.16	TC2N	tandem C2 domains, nuclear	10830	0.2
chr3_101229742_101229893	0.16	SENP7	SUMO1/sentrin specific peptidase 7	2211	0.26
chr2_106375349_106375537	0.16	NCK2	NCK adaptor protein 2	13255	0.28
chr2_222385882_222386088	0.16	ENSG00000221432	.	1608	0.44
chr9_31336901_31337115	0.16	ENSG00000211510	.	562782	0.0
chr5_75626248_75626505	0.16	RP11-466P24.6		19089	0.25
chrX_78338727_78338878	0.15	GPR174	G protein-coupled receptor 174	87667	0.1
chr10_4178314_4178722	0.15	KLF6	Kruppel-like factor 6	351045	0.01
chr5_141503692_141503877	0.15	NDFIP1	Nedd4 family interacting protein 1	15714	0.23
chrX_20456293_20456479	0.15	ENSG00000252978	.	13840	0.3
chr13_48760783_48760934	0.15	ITM2B	integral membrane protein 2B	46436	0.16
chr5_56145818_56146186	0.15	ENSG00000238717	.	6973	0.16
chr15_38959465_38959802	0.15	C15orf53	chromosome 15 open reading frame 53	29166	0.22
chr6_35635066_35635406	0.15	ENSG00000265527	.	2670	0.2
chr19_14461542_14461693	0.15	CD97	CD97 molecule	30351	0.13
chr2_106402335_106402603	0.15	NCK2	NCK adaptor protein 2	30546	0.22
chr5_61873952_61874158	0.15	LRRC70	leucine rich repeat containing 70	507	0.52
chr17_4263545_4263821	0.15	ENSG00000263882	.	4065	0.2

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of VAX2_RHOXF2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.2	GO:0001878	response to yeast(GO:0001878)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.2	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.0	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.3	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.1	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.1	GO:0034086	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.2	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0032714	negative regulation of interleukin-5 production(GO:0032714)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.2	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.1	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.2	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0060605	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.1	GO:0000042	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.1	GO:0051712	positive regulation of killing of cells of other organism(GO:0051712)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.2	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.0	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.1	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.1	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.2	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.1	GO:0060539	diaphragm development(GO:0060539)
0.0	0.1	GO:1904035	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.0	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.3	GO:0031648	protein destabilization(GO:0031648)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.0	GO:0044415	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.1	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.0	GO:0060510	lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0	0.1	GO:0050856	regulation of T cell receptor signaling pathway(GO:0050856)
0.0	0.0	GO:0018119	protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.0	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.1	GO:0097300	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.1	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.0	GO:0033091	positive regulation of immature T cell proliferation(GO:0033091)
0.0	0.2	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.2	GO:0032733	positive regulation of interleukin-10 production(GO:0032733)
0.0	0.0	GO:0033088	regulation of immature T cell proliferation in thymus(GO:0033084) negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.1	GO:0033235	positive regulation of protein sumoylation(GO:0033235)
0.0	0.0	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.0	GO:0051097	negative regulation of helicase activity(GO:0051097)
0.0	0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.2	GO:0043392	negative regulation of DNA binding(GO:0043392)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:0010715	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.2	GO:0008347	glial cell migration(GO:0008347)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.0	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.0	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.0	GO:2001234	negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0	0.0	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:1904376	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.0	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.0	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0051294	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.0	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.1	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0017085	response to insecticide(GO:0017085)
0.0	0.0	GO:0015825	L-serine transport(GO:0015825)
0.0	0.3	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0	0.0	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.0	GO:1903312	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.1	GO:0032527	protein exit from endoplasmic reticulum(GO:0032527)
0.0	0.0	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0	0.3	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.0	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0000098	sulfur amino acid catabolic process(GO:0000098)
0.0	0.1	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.0	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.3	GO:0046677	response to antibiotic(GO:0046677)
0.0	0.0	GO:0015705	iodide transport(GO:0015705)
0.0	0.3	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.0	GO:0009732	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.1	GO:0033081	regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0001705	ectoderm formation(GO:0001705)
0.0	0.0	GO:0048024	regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0	0.0	GO:0051901	positive regulation of mitochondrial depolarization(GO:0051901) positive regulation of membrane depolarization(GO:1904181)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.0	GO:0032060	bleb assembly(GO:0032060)
0.0	0.0	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.0	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.0	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.0	GO:0007097	nuclear migration(GO:0007097)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0007042	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.0	GO:0006047	UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:0015939	pantothenate metabolic process(GO:0015939)
0.0	0.1	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.2	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0043159	acrosomal matrix(GO:0043159)
0.0	0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.3	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.2	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.0	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.0	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0002178	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.2	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.1	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.0	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.0	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.0	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.0	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0043209	myelin sheath(GO:0043209)
0.0	0.1	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.0	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.2	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.1	0.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.2	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.3	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.2	GO:0001846	opsonin binding(GO:0001846)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.3	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.3	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.3	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.0	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.2	GO:0004303	estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0	0.0	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.0	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.0	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.1	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.0	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.3	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.1	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.2	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.0	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.1	GO:0016273	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.0	GO:0000739	obsolete DNA strand annealing activity(GO:0000739)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.0	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0017069	snRNA binding(GO:0017069)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.0	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.0	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.2	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.0	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0016530	metallochaperone activity(GO:0016530)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.0	0.1	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.0	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0	0.0	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.0	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.2	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.0	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.2	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.7	PID REELIN PATHWAY	Reelin signaling pathway
0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.1	PID S1P S1P4 PATHWAY	S1P4 pathway
0.8	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.4	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.4	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.1	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	PID CD40 PATHWAY	CD40/CD40L signaling
0.5	PID TNF PATHWAY	TNF receptor signaling pathway
0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.3	PID ALK1 PATHWAY	ALK1 signaling events
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.3	PID FOXO PATHWAY	FoxO family signaling
0.1	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.2	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	PID IL3 PATHWAY	IL3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.3	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.3	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.3	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.6	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.4	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.3	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.2	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.3	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.1	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.4	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.2	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.1	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.1	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling