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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for VSX1

Z-value: 1.29

Motif logo

Transcription factors associated with VSX1

Gene Symbol	Gene ID	Gene Info
VSX1 Ensembl NCBI GeneCards UniProt	ENSG00000100987.10	VSX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
VSX1	chr20_25071203_25071354	8282	0.211093	-0.82	6.9e-03	Click!
VSX1	chr20_25057715_25057866	4977	0.223332	-0.79	1.1e-02	Click!
VSX1	chr20_25071716_25071887	8805	0.209608	-0.74	2.1e-02	Click!
VSX1	chr20_25064708_25064859	1787	0.376087	-0.68	4.5e-02	Click!
VSX1	chr20_25058000_25058151	4692	0.227015	-0.64	6.5e-02	Click!

Activity of the VSX1 motif across conditions

Conditions sorted by the z-value of the VSX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_33934050_33934291	0.77	LMO2	LIM domain only 2 (rhombotin-like 1)	20334	0.2
chr12_89453867_89454269	0.67	ENSG00000238302	.	221994	0.02
chr14_101308246_101309004	0.63	ENSG00000214548	.	7020	0.04
chr4_140958813_140959347	0.55	RP11-392B6.1		90089	0.09
chr20_30743365_30743658	0.54	ENSG00000265736	.	36957	0.11
chr2_66735450_66735818	0.50	MEIS1	Meis homeobox 1	425	0.88
chr8_27501056_27501559	0.49	SCARA3	scavenger receptor class A, member 3	9609	0.16
chr3_70882578_70882827	0.49	ENSG00000206939	.	25201	0.23
chr2_207972754_207973110	0.48	ENSG00000253008	.	1865	0.35
chr8_108208326_108208625	0.46	ENSG00000211995	.	58251	0.16
chr12_26811451_26811602	0.46	RP11-666F17.1		35224	0.22
chr14_100240950_100241315	0.45	EML1	echinoderm microtubule associated protein like 1	1091	0.59
chr12_109060942_109061130	0.44	ENSG00000238457	.	1188	0.4
chr6_85293592_85293821	0.44	RP11-132M7.3		105437	0.08
chr6_37669094_37669483	0.42	MDGA1	MAM domain containing glycosylphosphatidylinositol anchor 1	2206	0.4
chr9_107630817_107631231	0.41	RP11-217B7.2		58810	0.12
chr2_36720605_36720756	0.41	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	20153	0.19
chr8_145562069_145562399	0.41	SCRT1	scratch family zinc finger 1	2291	0.12
chr17_26498050_26498459	0.41	PYY2	peptide YY, 2 (pseudogene)	56078	0.09
chr6_39787204_39787470	0.40	DAAM2	dishevelled associated activator of morphogenesis 2	26543	0.21
chr7_41910301_41910559	0.40	AC005027.3		165497	0.04
chr17_66379311_66379462	0.39	ENSG00000207561	.	41303	0.14
chr8_116430587_116430872	0.39	TRPS1	trichorhinophalangeal syndrome I	73719	0.12
chr4_7649546_7649747	0.39	SORCS2	sortilin-related VPS10 domain containing receptor 2	86361	0.09
chr9_94154220_94154371	0.39	AUH	AU RNA binding protein/enoyl-CoA hydratase	30100	0.21
chr3_188692042_188692831	0.38	TPRG1	tumor protein p63 regulated 1	27433	0.27
chr17_13316675_13316828	0.38	ENSG00000266115	.	86894	0.1
chr4_167261736_167261962	0.37	ENSG00000206711	.	27663	0.26
chr1_32123952_32124158	0.37	RP11-73M7.6		1196	0.35
chrX_39586002_39586188	0.36	ENSG00000264618	.	59982	0.14
chr10_20884985_20885136	0.36	ENSG00000265372	.	44161	0.21
chr1_118238359_118238510	0.36	ENSG00000212266	.	7070	0.28
chr9_90131509_90131738	0.35	DAPK1	death-associated protein kinase 1	17703	0.23
chr2_38054791_38055066	0.35	CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3	89317	0.09
chr3_171978629_171978920	0.35	ENSG00000243398	.	23658	0.19
chr12_56917827_56917978	0.35	RBMS2	RNA binding motif, single stranded interacting protein 2	2119	0.23
chr3_129311849_129312381	0.35	ENSG00000239437	.	1923	0.28
chr2_80220201_80220486	0.34	AC016716.2		37334	0.22
chr8_86971952_86972334	0.34	ATP6V0D2	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2	27409	0.23
chr14_77873001_77873391	0.34	FKSG61		9545	0.11
chr13_108486642_108486793	0.34	FAM155A-IT1	FAM155A intronic transcript 1 (non-protein coding)	1082	0.62
chr12_118770370_118770546	0.34	TAOK3	TAO kinase 3	26452	0.21
chr11_118393531_118393828	0.34	TTC36	tetratricopeptide repeat domain 36	4508	0.12
chr14_24837858_24838637	0.34	NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	41	0.94
chr21_39659541_39659821	0.33	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	8798	0.29
chr4_57597998_57598267	0.33	HOPX	HOP homeobox	50067	0.12
chr7_75952019_75952170	0.33	HSPB1	heat shock 27kDa protein 1	19200	0.14
chr13_27597624_27597775	0.33	USP12-AS1	USP12 antisense RNA 1	139293	0.04
chr3_71030532_71030802	0.33	FOXP1	forkhead box P1	83410	0.1
chr1_149743371_149743522	0.33	FCGR1A	Fc fragment of IgG, high affinity Ia, receptor (CD64)	10781	0.09
chr7_130904360_130904511	0.33	MKLN1	muskelin 1, intracellular mediator containing kelch motifs	65386	0.12
chr21_40856650_40856801	0.33	SH3BGR	SH3 domain binding glutamic acid-rich protein	15024	0.18
chr13_101539869_101540020	0.33	NALCN-AS1	NALCN antisense RNA 1	179365	0.03
chr15_85548703_85549030	0.33	PDE8A	phosphodiesterase 8A	23654	0.18
chr10_94756810_94756961	0.32	EXOC6	exocyst complex component 6	346	0.91
chr20_19478003_19478154	0.32	ENSG00000216017	.	92753	0.08
chr2_200604102_200604338	0.32	FTCDNL1	formiminotransferase cyclodeaminase N-terminal like	111376	0.07
chr10_79021361_79021706	0.31	RP11-328K22.1		52166	0.15
chr8_11319032_11319411	0.31	FAM167A	family with sequence similarity 167, member A	5055	0.17
chr3_12632091_12632446	0.31	RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	18477	0.14
chr10_17217462_17217735	0.31	TRDMT1	tRNA aspartic acid methyltransferase 1	939	0.58
chr11_20111347_20111612	0.31	NAV2-AS1	NAV2 antisense RNA 1	30699	0.17
chr8_20125798_20125949	0.31	LZTS1	leucine zipper, putative tumor suppressor 1	13070	0.19
chr4_89647157_89647308	0.31	FAM13A-AS1	FAM13A antisense RNA 1	4366	0.21
chr1_208250614_208250765	0.31	CD34	CD34 molecule	165942	0.04
chr9_112955106_112955494	0.31	C9orf152	chromosome 9 open reading frame 152	15169	0.23
chr5_15249746_15249921	0.31	ENSG00000202269	.	138804	0.05
chr14_77238822_77239041	0.31	VASH1	vasohibin 1	5418	0.19
chr10_30831887_30832121	0.31	ENSG00000239744	.	12829	0.24
chr10_70089432_70089583	0.31	HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	2325	0.26
chr1_201706190_201706778	0.31	RP11-90L20.2		150	0.93
chr15_57574971_57575503	0.31	TCF12	transcription factor 12	584	0.78
chr18_32694549_32694734	0.30	MAPRE2	microtubule-associated protein, RP/EB family, member 2	73027	0.11
chr18_54126758_54127059	0.30	TXNL1	thioredoxin-like 1	154814	0.04
chr4_122569979_122570130	0.30	ANXA5	annexin A5	48063	0.16
chr3_105699405_105699556	0.30	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	111084	0.08
chr9_81321983_81322311	0.30	PSAT1	phosphoserine aminotransferase 1	410088	0.01
chr11_14562787_14563173	0.30	PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1	20738	0.2
chr11_126084700_126085013	0.30	ENSG00000222067	.	483	0.66
chr7_80348902_80349053	0.30	CD36	CD36 molecule (thrombospondin receptor)	46285	0.2
chr11_16377737_16377888	0.30	SOX6	SRY (sex determining region Y)-box 6	14997	0.3
chr8_91795476_91795627	0.30	NECAB1	N-terminal EF-hand calcium binding protein 1	8227	0.21
chr2_158326449_158327167	0.29	CYTIP	cytohesin 1 interacting protein	18533	0.22
chr12_66270554_66270788	0.29	RP11-366L20.2	Uncharacterized protein	4687	0.21
chr6_14638853_14639371	0.29	ENSG00000206960	.	7654	0.34
chr9_125766060_125766211	0.29	RABGAP1	RAB GTPase activating protein 1	29653	0.12
chr11_131479604_131479755	0.29	NTM	neurotrimin	27774	0.2
chr1_100976278_100976464	0.29	RP5-837M10.4		24818	0.19
chr7_16568149_16568300	0.29	LRRC72	leucine rich repeat containing 72	1703	0.34
chr12_1727335_1727720	0.29	WNT5B	wingless-type MMTV integration site family, member 5B	1305	0.46
chr3_72036989_72037274	0.29	ENSG00000239250	.	160803	0.04
chr17_29925275_29925666	0.29	ENSG00000199187	.	23040	0.11
chr12_71040223_71040434	0.29	PTPRB	protein tyrosine phosphatase, receptor type, B	9108	0.29
chr5_123171717_123171868	0.29	CSNK1G3	casein kinase 1, gamma 3	247673	0.02
chr4_187545719_187545870	0.29	FAT1	FAT atypical cadherin 1	26616	0.2
chr6_22821870_22822021	0.29	HDGFL1	hepatoma derived growth factor-like 1	252150	0.02
chr18_5516139_5516334	0.29	EPB41L3	erythrocyte membrane protein band 4.1-like 3	5186	0.21
chr8_80226395_80226546	0.29	ENSG00000264969	.	216872	0.02
chr7_92382094_92382391	0.28	ENSG00000206763	.	51114	0.14
chr3_99672505_99672656	0.28	ENSG00000264897	.	10662	0.27
chr5_17282736_17283060	0.28	ENSG00000252908	.	42178	0.15
chr2_36680268_36680419	0.28	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	60490	0.12
chr3_43827332_43827483	0.28	ABHD5	abhydrolase domain containing 5	74208	0.11
chr1_221187846_221187997	0.28	HLX	H2.0-like homeobox	133337	0.05
chr15_67006142_67006408	0.28	SMAD6	SMAD family member 6	2240	0.39
chr19_5955434_5955585	0.28	RANBP3	RAN binding protein 3	22581	0.09
chr12_24383050_24383201	0.28	ENSG00000216192	.	17770	0.3
chr20_56050830_56050981	0.28	CTCFL	CCCTC-binding factor (zinc finger protein)-like	48408	0.12
chr5_146917975_146918126	0.28	DPYSL3	dihydropyrimidinase-like 3	28431	0.24
chr11_112036083_112036234	0.28	IL18	interleukin 18 (interferon-gamma-inducing factor)	1318	0.25
chr1_200332138_200332309	0.28	ZNF281	zinc finger protein 281	46897	0.19
chr2_98708440_98708797	0.28	VWA3B	von Willebrand factor A domain containing 3B	4919	0.31
chr18_65188248_65188399	0.27	DSEL	dermatan sulfate epimerase-like	4106	0.29
chr11_103924198_103924349	0.27	PDGFD	platelet derived growth factor D	16519	0.22
chr17_30586530_30586681	0.27	RHBDL3	rhomboid, veinlet-like 3 (Drosophila)	6590	0.16
chr2_98546607_98546758	0.27	ENSG00000238719	.	17102	0.21
chr7_77130046_77130330	0.27	PTPN12	protein tyrosine phosphatase, non-receptor type 12	36404	0.19
chr18_60117683_60118024	0.27	ZCCHC2	zinc finger, CCHC domain containing 2	72387	0.1
chr12_26171601_26171752	0.27	RASSF8	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	2697	0.33
chr11_63278500_63278680	0.27	LGALS12	lectin, galactoside-binding, soluble, 12	3131	0.21
chr20_43176865_43177016	0.27	PKIG	protein kinase (cAMP-dependent, catalytic) inhibitor gamma	16370	0.14
chr10_6390281_6390901	0.27	DKFZP667F0711		1687	0.47
chr15_50392799_50393114	0.27	ATP8B4	ATPase, class I, type 8B, member 4	13745	0.23
chr9_5450626_5450802	0.27	CD274	CD274 molecule	189	0.95
chr11_34338329_34338672	0.27	ABTB2	ankyrin repeat and BTB (POZ) domain containing 2	40302	0.19
chr5_153350030_153350181	0.27	FAM114A2	family with sequence similarity 114, member A2	66765	0.12
chr6_144126645_144127098	0.27	LTV1	LTV1 homolog (S. cerevisiae)	37610	0.18
chr6_82477389_82477689	0.27	ENSG00000206886	.	3798	0.25
chr7_91513061_91513319	0.27	MTERF	mitochondrial transcription termination factor	3156	0.35
chr1_149358385_149358581	0.27	FCGR1C	Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene	10811	0.14
chr10_80893653_80893925	0.27	ZMIZ1	zinc finger, MIZ-type containing 1	64997	0.13
chr2_145270130_145270606	0.27	ZEB2	zinc finger E-box binding homeobox 2	4747	0.27
chr21_37360811_37360962	0.27	RUNX1	runt-related transcription factor 1	16079	0.16
chr9_8718077_8718278	0.27	PTPRD	protein tyrosine phosphatase, receptor type, D	15717	0.22
chr11_61467806_61468091	0.27	DAGLA	diacylglycerol lipase, alpha	20043	0.15
chr3_16005968_16006176	0.27	ENSG00000207815	.	90794	0.08
chr8_72770819_72770970	0.27	MSC	musculin	14191	0.18
chr6_82476723_82477129	0.26	ENSG00000206886	.	3185	0.27
chr8_105598551_105598718	0.26	LRP12	low density lipoprotein receptor-related protein 12	2600	0.3
chr3_151122388_151122772	0.26	P2RY12	purinergic receptor P2Y, G-protein coupled, 12	19980	0.18
chr3_71297288_71297645	0.26	FOXP1	forkhead box P1	3150	0.35
chr6_70294956_70295144	0.26	ENSG00000265362	.	36215	0.23
chr12_124474900_124475063	0.26	ZNF664	zinc finger protein 664	17139	0.08
chr4_141058656_141058807	0.26	RP11-392B6.1		9562	0.23
chr12_109003340_109003491	0.26	TMEM119	transmembrane protein 119	11319	0.13
chr3_114951923_114952074	0.26	ZBTB20	zinc finger and BTB domain containing 20	85880	0.11
chr8_41786362_41786614	0.26	KAT6A	K(lysine) acetyltransferase 6A	29393	0.17
chr13_47317430_47317715	0.26	ESD	esterase D	38131	0.19
chr1_222507571_222507774	0.26	ENSG00000222399	.	169405	0.03
chr1_209465302_209465601	0.26	ENSG00000230937	.	140027	0.05
chr4_120580539_120580789	0.26	PDE5A	phosphodiesterase 5A, cGMP-specific	30518	0.22
chr12_19805873_19806024	0.26	ENSG00000200885	.	71421	0.13
chr3_124869997_124870148	0.26	ENSG00000264986	.	324	0.89
chr11_67886734_67886961	0.26	CHKA	choline kinase alpha	1448	0.32
chr14_72179521_72179805	0.26	SIPA1L1	signal-induced proliferation-associated 1 like 1	94190	0.09
chr3_72059056_72059299	0.26	ENSG00000239250	.	182849	0.03
chr11_34438827_34438978	0.26	CAT	catalase	21570	0.21
chr3_18585987_18586243	0.25	ENSG00000228956	.	17451	0.28
chr10_115033205_115033385	0.25	ENSG00000238380	.	79889	0.11
chr18_9704973_9705544	0.25	RAB31	RAB31, member RAS oncogene family	2904	0.31
chr4_52798315_52798466	0.25	DCUN1D4	DCN1, defective in cullin neddylation 1, domain containing 4	40417	0.19
chr1_178102702_178103151	0.25	RASAL2	RAS protein activator like 2	39650	0.22
chr6_154808814_154808965	0.25	CNKSR3	CNKSR family member 3	9264	0.31
chr14_75428743_75429108	0.25	PGF	placental growth factor	6438	0.15
chr18_10269165_10269316	0.25	ENSG00000239031	.	120757	0.06
chr16_85295971_85296292	0.25	ENSG00000266307	.	43800	0.16
chr10_62109936_62110087	0.25	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	39477	0.23
chr9_4927697_4927848	0.25	ENSG00000238362	.	40325	0.13
chr12_57620818_57620969	0.25	ENSG00000202067	.	864	0.38
chr2_58926103_58926452	0.25	FANCL	Fanconi anemia, complementation group L	457770	0.01
chr1_64208231_64208526	0.25	ROR1	receptor tyrosine kinase-like orphan receptor 1	31315	0.2
chr7_40803485_40803636	0.25	AC005160.3		11597	0.32
chr20_43330295_43330446	0.25	RP11-445H22.3		5633	0.14
chr5_176901771_176902224	0.25	DBN1	drebrin 1	595	0.56
chr9_95298761_95298917	0.25	ECM2	extracellular matrix protein 2, female organ and adipocyte specific	98	0.97
chr5_67829635_67829905	0.25	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	241374	0.02
chr10_17064484_17064884	0.25	CUBN	cubilin (intrinsic factor-cobalamin receptor)	38490	0.2
chr1_35309309_35309515	0.25	RP5-997D16.2		6883	0.15
chr13_41639811_41639962	0.25	WBP4	WW domain binding protein 4	4190	0.18
chr10_73000505_73000775	0.25	UNC5B-AS1	UNC5B antisense RNA 1	22655	0.16
chr10_102813488_102813726	0.25	KAZALD1	Kazal-type serine peptidase inhibitor domain 1	7991	0.12
chr6_148845405_148845556	0.24	ENSG00000223322	.	104	0.98
chr7_141061897_141062048	0.24	RP5-842K16.2		69096	0.12
chr6_135740137_135740472	0.24	AHI1	Abelson helper integration site 1	7658	0.26
chr1_221096418_221096569	0.24	HLX	H2.0-like homeobox	41909	0.16
chr4_169536059_169536210	0.24	PALLD	palladin, cytoskeletal associated protein	16632	0.21
chr17_67925463_67925614	0.24	ENSG00000252100	.	19550	0.24
chr3_155926514_155926665	0.24	KCNAB1-AS2	KCNAB1 antisense RNA 2	19083	0.25
chr5_58473985_58474185	0.24	PDE4D	phosphodiesterase 4D, cAMP-specific	97860	0.09
chr15_71824033_71824261	0.24	THSD4	thrombospondin, type I, domain containing 4	15428	0.25
chr3_81913343_81913495	0.24	GBE1	glucan (1,4-alpha-), branching enzyme 1	102107	0.09
chr12_20000530_20000725	0.24	ENSG00000200885	.	123258	0.06
chr13_77319833_77320172	0.24	KCTD12	potassium channel tetramerization domain containing 12	140523	0.05
chr19_39157057_39157758	0.24	ACTN4	actinin, alpha 4	19029	0.11
chr2_36780540_36780944	0.24	AC007401.2	Uncharacterized protein	1331	0.45
chrX_124435894_124436045	0.24	ENSG00000263886	.	14344	0.31
chr11_69264697_69264848	0.24	CCND1	cyclin D1	191083	0.03
chr1_213499715_213500068	0.24	RPS6KC1	ribosomal protein S6 kinase, 52kDa, polypeptide 1	275287	0.01
chr20_50419228_50419379	0.24	SALL4	spalt-like transcription factor 4	244	0.94
chr5_124202510_124202693	0.24	ZNF608	zinc finger protein 608	118101	0.05

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of VSX1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.2	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.1	0.4	GO:0030210	heparin biosynthetic process(GO:0030210)
0.1	0.3	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.6	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1	0.2	GO:0007132	meiotic metaphase I(GO:0007132)
0.1	0.6	GO:0060216	definitive hemopoiesis(GO:0060216)
0.1	0.1	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.1	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1	0.2	GO:0071436	sodium ion export(GO:0071436)
0.1	0.2	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1	0.2	GO:0060437	lung growth(GO:0060437)
0.1	0.2	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.1	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.1	0.2	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.1	0.2	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.2	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1	0.2	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.1	0.1	GO:0010193	response to ozone(GO:0010193)
0.1	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.1	0.2	GO:0048245	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.1	0.2	GO:0070932	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.2	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.0	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0	0.3	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.1	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.1	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.1	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.3	GO:0061001	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.1	GO:0045964	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0	0.1	GO:0060693	regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.0	0.4	GO:0042953	lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0	0.2	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.3	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.1	GO:0021508	floor plate formation(GO:0021508)
0.0	0.1	GO:0021825	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.2	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.2	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0	0.2	GO:0060174	limb bud formation(GO:0060174)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.0	GO:0043301	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.1	GO:0042109	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.1	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.2	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.3	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.0	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.1	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.2	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.0	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0051657	maintenance of organelle location(GO:0051657)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0051142	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0	0.2	GO:0060760	positive regulation of response to cytokine stimulus(GO:0060760)
0.0	0.2	GO:1901532	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.1	GO:0043116	negative regulation of vascular permeability(GO:0043116)
0.0	0.1	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.3	GO:0009650	UV protection(GO:0009650)
0.0	0.0	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.1	GO:0042984	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.6	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.0	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.0	GO:0061299	retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0031062	positive regulation of histone methylation(GO:0031062)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.2	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0030540	female genitalia development(GO:0030540)
0.0	0.1	GO:0016115	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.0	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.2	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0045332	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332) regulation of membrane lipid distribution(GO:0097035)
0.0	0.1	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.0	GO:0048342	paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0	0.1	GO:0019673	GDP-mannose metabolic process(GO:0019673)
0.0	0.0	GO:0051569	regulation of histone H3-K4 methylation(GO:0051569)
0.0	0.1	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.2	GO:0034605	cellular response to heat(GO:0034605)
0.0	0.0	GO:0001820	serotonin secretion(GO:0001820)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.0	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.1	GO:0055093	response to increased oxygen levels(GO:0036296) response to hyperoxia(GO:0055093)
0.0	0.0	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:0042663	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.1	GO:2000647	negative regulation of stem cell proliferation(GO:2000647)
0.0	0.1	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.1	GO:0034260	negative regulation of GTPase activity(GO:0034260)
0.0	0.1	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.3	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.1	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.0	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.1	GO:0060707	trophoblast giant cell differentiation(GO:0060707)
0.0	0.1	GO:0010591	regulation of lamellipodium assembly(GO:0010591)
0.0	0.2	GO:0072488	ammonium transmembrane transport(GO:0072488)
0.0	0.0	GO:0031392	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.1	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.1	GO:0010225	response to UV-C(GO:0010225)
0.0	0.2	GO:0007320	insemination(GO:0007320)
0.0	0.1	GO:0010875	positive regulation of cholesterol efflux(GO:0010875)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0002667	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.0	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0	0.1	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0	0.0	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.1	GO:0016241	regulation of macroautophagy(GO:0016241)
0.0	0.1	GO:0043306	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0070207	protein homotrimerization(GO:0070207)
0.0	0.1	GO:0051788	response to misfolded protein(GO:0051788)
0.0	0.2	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.1	GO:0006264	mitochondrial DNA replication(GO:0006264)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.1	GO:0060736	prostate gland growth(GO:0060736)
0.0	0.0	GO:0051877	pigment granule aggregation in cell center(GO:0051877)
0.0	0.1	GO:0000959	mitochondrial RNA metabolic process(GO:0000959) transcription from mitochondrial promoter(GO:0006390)
0.0	0.0	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.0	GO:0042637	catagen(GO:0042637)
0.0	0.0	GO:0034694	response to prostaglandin(GO:0034694)
0.0	0.1	GO:0034505	tooth mineralization(GO:0034505)
0.0	0.1	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.0	GO:0002246	wound healing involved in inflammatory response(GO:0002246) connective tissue replacement involved in inflammatory response wound healing(GO:0002248) inflammatory response to wounding(GO:0090594) connective tissue replacement(GO:0097709)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:0034379	very-low-density lipoprotein particle assembly(GO:0034379)
0.0	0.0	GO:1901881	positive regulation of protein depolymerization(GO:1901881)
0.0	0.1	GO:0031652	regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.0	GO:0010755	regulation of plasminogen activation(GO:0010755) negative regulation of plasminogen activation(GO:0010757)
0.0	0.0	GO:0017000	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.4	GO:0015914	phospholipid transport(GO:0015914)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.2	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.1	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0090083	regulation of inclusion body assembly(GO:0090083)
0.0	0.0	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.2	GO:0045907	positive regulation of vasoconstriction(GO:0045907)
0.0	0.1	GO:0034644	cellular response to UV(GO:0034644)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.0	GO:0043931	ossification involved in bone maturation(GO:0043931)
0.0	0.0	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0043537	negative regulation of blood vessel endothelial cell migration(GO:0043537)
0.0	0.0	GO:0001660	fever generation(GO:0001660)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.2	GO:0006825	copper ion transport(GO:0006825)
0.0	0.2	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.0	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.0	GO:0046449	allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.0	GO:0033145	positive regulation of intracellular steroid hormone receptor signaling pathway(GO:0033145)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)
0.0	0.0	GO:0071025	RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0	0.0	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.0	0.1	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.0	0.0	GO:0021891	olfactory bulb interneuron development(GO:0021891)
0.0	0.0	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.0	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.0	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.0	GO:0051883	disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.0	0.0	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.0	GO:0006570	tyrosine metabolic process(GO:0006570)
0.0	0.0	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.1	GO:0043278	response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.0	0.0	GO:0019859	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.0	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.0	GO:0051898	negative regulation of protein kinase B signaling(GO:0051898)
0.0	0.0	GO:0071421	manganese ion transmembrane transport(GO:0071421)
0.0	0.0	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.1	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.1	GO:0006895	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.0	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.0	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0002021	response to dietary excess(GO:0002021)
0.0	0.0	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	0.3	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.4	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.3	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.3	GO:0000145	exocyst(GO:0000145)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.4	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0043260	laminin-11 complex(GO:0043260)
0.0	0.2	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.3	GO:0030315	T-tubule(GO:0030315)
0.0	0.2	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.0	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.2	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.2	GO:0031941	filamentous actin(GO:0031941)
0.0	0.2	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.2	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.1	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.0	GO:0098651	basement membrane collagen trimer(GO:0098651)
0.0	0.2	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.0	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.5	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	0.4	GO:0005902	microvillus(GO:0005902)
0.0	0.1	GO:0031672	A band(GO:0031672)
0.0	0.3	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.0	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.0	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.1	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.0	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.1	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.2	GO:0005581	collagen trimer(GO:0005581)
0.0	0.6	GO:0030016	myofibril(GO:0030016)
0.0	0.3	GO:0030018	Z disc(GO:0030018)
0.0	0.0	GO:0070852	cell body fiber(GO:0070852)
0.0	0.3	GO:0034704	calcium channel complex(GO:0034704)
0.0	0.0	GO:0005638	lamin filament(GO:0005638)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.0	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.1	GO:0034464	BBSome(GO:0034464)
0.0	0.0	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.3	GO:0042641	actomyosin(GO:0042641)
0.0	0.1	GO:0032389	MutLalpha complex(GO:0032389)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0070052	collagen V binding(GO:0070052)
0.1	0.3	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1	0.2	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.2	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	0.2	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.2	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.2	GO:0042805	actinin binding(GO:0042805)
0.0	0.2	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.2	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.2	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.2	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.2	GO:1901567	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.5	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.5	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.2	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.2	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.5	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.2	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.2	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.2	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	0.1	GO:0033265	choline binding(GO:0033265)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.4	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.2	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.1	GO:0004339	glucan 1,4-alpha-glucosidase activity(GO:0004339)
0.0	0.4	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.1	GO:0004500	dopamine beta-monooxygenase activity(GO:0004500)
0.0	0.1	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.0	0.1	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0031690	adrenergic receptor binding(GO:0031690)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.2	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.0	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.1	GO:0004551	nucleotide diphosphatase activity(GO:0004551)
0.0	0.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.1	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.4	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0	0.0	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.4	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.2	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.0	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.1	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.1	GO:0034584	piRNA binding(GO:0034584)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0030354	melanin-concentrating hormone activity(GO:0030354)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0030275	LRR domain binding(GO:0030275)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.0	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.0	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.0	GO:0005415	nucleoside:sodium symporter activity(GO:0005415)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.2	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.0	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0	0.2	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.0	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.0	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.2	GO:0005452	inorganic anion exchanger activity(GO:0005452)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.0	GO:0032190	acrosin binding(GO:0032190)
0.0	0.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.0	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.3	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.2	GO:0030552	cAMP binding(GO:0030552)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0001077	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	0.1	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.2	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.2	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.0	GO:0030172	troponin C binding(GO:0030172)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.0	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.2	GO:0030971	receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0	0.2	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.1	GO:0015368	calcium:cation antiporter activity(GO:0015368)
0.0	0.0	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.0	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.0	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.0	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.0	GO:0045569	TRAIL binding(GO:0045569)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
1.1	NABA COLLAGENS	Genes encoding collagen proteins
0.0	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.3	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4	PID S1P S1P2 PATHWAY	S1P2 pathway
0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3	ST G ALPHA S PATHWAY	G alpha s Pathway
0.3	ST GA12 PATHWAY	G alpha 12 Pathway
0.2	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.2	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	PID SHP2 PATHWAY	SHP2 signaling
0.1	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	Genes involved in Cytokine Signaling in Immune system
0.1	0.1	REACTOME SIGNALING BY FGFR	Genes involved in Signaling by FGFR
0.0	0.0	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0	0.0	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.0	0.4	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.2	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.3	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.0	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.8	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.0	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
0.0	0.1	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.0	0.2	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.0	0.2	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0	0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.0	REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	Genes involved in Activation of the pre-replicative complex
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.4	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.3	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.0	0.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.2	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.2	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.1	REACTOME IL 3 5 AND GM CSF SIGNALING	Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.0	0.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.1	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.0	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.0	0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.1	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.3	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	0.1	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.1	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
0.0	0.1	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)