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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZBTB18

Z-value: 2.07

Motif logo

Transcription factors associated with ZBTB18

Gene Symbol	Gene ID	Gene Info
ZBTB18 Ensembl NCBI GeneCards UniProt	ENSG00000179456.9	ZBTB18

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZBTB18	chr1_244217966_244218117	3456	0.265015	-0.80	9.7e-03	Click!
ZBTB18	chr1_244210618_244210958	3797	0.264146	-0.76	1.7e-02	Click!
ZBTB18	chr1_244165402_244165576	49096	0.149266	-0.68	4.4e-02	Click!
ZBTB18	chr1_244214937_244215088	427	0.859900	-0.61	8.1e-02	Click!
ZBTB18	chr1_244215609_244215953	1196	0.521680	-0.60	8.9e-02	Click!

Activity of the ZBTB18 motif across conditions

Conditions sorted by the z-value of the ZBTB18 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_40100780_40100931	0.90	RP1-144F13.3		1767	0.23
chr2_238131211_238131483	0.87	AC112715.2	Uncharacterized protein	34387	0.2
chr17_48343728_48343879	0.71	TMEM92	transmembrane protein 92	4964	0.14
chr17_71039617_71039918	0.70	SLC39A11	solute carrier family 39, member 11	46136	0.17
chr12_28721330_28721481	0.67	CCDC91	coiled-coil domain containing 91	19408	0.26
chr5_56833824_56833975	0.66	ACTBL2	actin, beta-like 2	55263	0.14
chr19_48674183_48675124	0.65	C19orf68	chromosome 19 open reading frame 68	704	0.32
chr10_100108984_100109336	0.63	ENSG00000221419	.	45904	0.13
chr11_15178522_15178673	0.62	INSC	inscuteable homolog (Drosophila)	7943	0.3
chr20_56622785_56622936	0.60	ENSG00000221385	.	19652	0.22
chr3_98625022_98625173	0.59	ENSG00000207331	.	2206	0.27
chr2_238215371_238215540	0.58	AC112715.2	Uncharacterized protein	49721	0.15
chr11_130608199_130608484	0.56	C11orf44	chromosome 11 open reading frame 44	65490	0.14
chr21_29827131_29827282	0.56	ENSG00000251894	.	288324	0.01
chr20_3667221_3667372	0.55	ADAM33	ADAM metallopeptidase domain 33	4403	0.16
chr14_75072847_75072998	0.55	LTBP2	latent transforming growth factor beta binding protein 2	5853	0.22
chr18_10059619_10060204	0.54	ENSG00000263630	.	54717	0.15
chr11_7912101_7912252	0.54	ENSG00000252769	.	1350	0.35
chr8_119499700_119499851	0.54	SAMD12	sterile alpha motif domain containing 12	93346	0.1
chr6_129507673_129507824	0.53	ENSG00000252554	.	250377	0.02
chr11_74561444_74561595	0.53	ENSG00000242999	.	4564	0.19
chr8_99021155_99021306	0.52	MATN2	matrilin 2	7542	0.15
chr1_246150406_246150557	0.52	RP11-83A16.1		46372	0.18
chr2_235934802_235934953	0.52	SH3BP4	SH3-domain binding protein 4	31393	0.26
chr3_73835223_73835374	0.52	PDZRN3	PDZ domain containing ring finger 3	161207	0.04
chr2_36657128_36657279	0.51	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	73589	0.11
chr20_23148002_23148153	0.51	ENSG00000201527	.	6469	0.24
chr14_68943525_68944196	0.51	RAD51B	RAD51 paralog B	65633	0.13
chr11_14432940_14433091	0.50	RRAS2	related RAS viral (r-ras) oncogene homolog 2	46963	0.15
chr13_114872368_114872623	0.50	RASA3-IT1	RASA3 intronic transcript 1 (non-protein coding)	1800	0.41
chr11_71698874_71699025	0.49	IL18BP	interleukin 18 binding protein	10638	0.11
chr15_49015763_49015914	0.49	RP11-485O10.2		59549	0.11
chr6_100716336_100716487	0.49	RP1-121G13.2		158583	0.04
chr17_17780568_17780719	0.48	TOM1L2	target of myb1-like 2 (chicken)	5265	0.19
chr9_101791785_101791940	0.47	TGFBR1	transforming growth factor, beta receptor 1	74458	0.09
chr11_118492770_118493048	0.47	AP002954.3		14429	0.11
chr1_44705174_44705804	0.47	ERI3-IT1	ERI3 intronic transcript 1 (non-protein coding)	4456	0.21
chr8_141908612_141908763	0.47	PTK2	protein tyrosine kinase 2	7820	0.26
chr2_232056745_232056896	0.47	ARMC9	armadillo repeat containing 9	6440	0.22
chr1_170656810_170656961	0.46	PRRX1	paired related homeobox 1	23807	0.25
chr2_19740386_19740537	0.46	OSR1	odd-skipped related transciption factor 1	182047	0.03
chr1_21588856_21589397	0.46	RP3-329E20.2		3449	0.23
chr2_151332991_151333142	0.46	RND3	Rho family GTPase 3	8830	0.33
chr8_26519218_26519369	0.46	DPYSL2	dihydropyrimidinase-like 2	83372	0.1
chr17_12630832_12630983	0.45	AC005358.1		4708	0.2
chr10_69802673_69802824	0.45	HERC4	HECT and RLD domain containing E3 ubiquitin protein ligase 4	3024	0.27
chr17_1683782_1683933	0.45	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	8844	0.12
chr9_117508350_117508501	0.45	TNFSF15	tumor necrosis factor (ligand) superfamily, member 15	45963	0.14
chr13_98905870_98906021	0.45	RP11-573N10.1		20041	0.17
chr15_99881623_99881774	0.45	AC022819.2	Uncharacterized protein	21870	0.18
chr9_82379139_82379290	0.45	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	57533	0.18
chr12_105812666_105812817	0.44	C12orf75	chromosome 12 open reading frame 75	88095	0.08
chr10_80916996_80917718	0.44	ZMIZ1	zinc finger, MIZ-type containing 1	88565	0.09
chr12_53474857_53475008	0.44	SPRYD3	SPRY domain containing 3	1728	0.22
chr15_70668335_70668710	0.44	ENSG00000200216	.	182947	0.03
chr7_151297671_151297822	0.44	PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	31693	0.18
chr3_134183959_134184110	0.44	CEP63	centrosomal protein 63kDa	20551	0.16
chr11_44058607_44058758	0.43	ACCSL	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like	10849	0.17
chr9_22040392_22040543	0.43	CDKN2B-AS1	CDKN2B antisense RNA 1	6283	0.2
chr3_88856750_88856901	0.43	EPHA3	EPH receptor A3	299849	0.01
chr22_27118545_27118696	0.43	CRYBA4	crystallin, beta A4	100692	0.07
chrY_27544696_27544847	0.43	ENSG00000272042	.	60283	0.14
chr6_144614901_144615052	0.43	UTRN	utrophin	2011	0.42
chr19_42785461_42786111	0.43	CIC	capicua transcriptional repressor	2386	0.14
chr4_89664108_89664259	0.43	FAM13A-AS1	FAM13A antisense RNA 1	21317	0.18
chr8_95299657_95299808	0.43	GEM	GTP binding protein overexpressed in skeletal muscle	25154	0.22
chrY_26417595_26417746	0.43	ENSG00000242425	.	60288	0.14
chr15_78182901_78183238	0.42	CSPG4P13	chondroitin sulfate proteoglycan 4 pseudogene 13	3957	0.18
chr12_6658690_6659153	0.42	IFFO1	intermediate filament family orphan 1	2145	0.13
chr5_65072338_65072489	0.42	NLN	neurolysin (metallopeptidase M3 family)	4830	0.27
chr14_52491686_52491966	0.42	NID2	nidogen 2 (osteonidogen)	13844	0.16
chr21_28778719_28778870	0.42	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	439962	0.01
chr8_95253991_95254142	0.42	GEM	GTP binding protein overexpressed in skeletal muscle	18932	0.21
chr7_130012625_130012776	0.42	CPA1	carboxypeptidase A1 (pancreatic)	7480	0.14
chr1_16343988_16344139	0.42	HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)	257	0.86
chr9_130502702_130502853	0.42	TOR2A	torsin family 2, member A	5173	0.1
chr9_89724167_89724318	0.42	C9orf170	chromosome 9 open reading frame 170	39317	0.21
chr18_56247162_56247463	0.42	ENSG00000252284	.	20551	0.14
chr6_136256944_136257095	0.41	ENSG00000238921	.	21126	0.21
chr9_136271156_136271307	0.41	REXO4	REX4, RNA exonuclease 4 homolog (S. cerevisiae)	9789	0.08
chr17_30662996_30663147	0.41	C17orf75	chromosome 17 open reading frame 75	690	0.62
chr9_114706444_114706595	0.41	ENSG00000266315	.	12139	0.2
chr17_48718114_48718630	0.41	ABCC3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	6154	0.13
chr14_58312690_58312841	0.41	ENSG00000252837	.	8387	0.24
chr14_88937631_88937782	0.41	PTPN21	protein tyrosine phosphatase, non-receptor type 21	1746	0.34
chr14_55057316_55057467	0.41	SAMD4A	sterile alpha motif domain containing 4A	22754	0.22
chr1_27730071_27730579	0.40	GPR3	G protein-coupled receptor 3	11177	0.13
chr1_157992444_157992595	0.39	KIRREL-IT1	KIRREL intronic transcript 1 (non-protein coding)	2821	0.3
chr11_10345196_10345347	0.39	AMPD3	adenosine monophosphate deaminase 3	6053	0.17
chr8_126582644_126582795	0.39	ENSG00000266452	.	125912	0.06
chr17_66592514_66592665	0.39	FAM20A	family with sequence similarity 20, member A	4941	0.26
chr1_214744112_214744263	0.39	PTPN14	protein tyrosine phosphatase, non-receptor type 14	19621	0.24
chr15_85888485_85888636	0.39	AKAP13	A kinase (PRKA) anchor protein 13	35258	0.15
chr1_120507427_120507715	0.39	RP5-1042I8.7		54335	0.13
chr6_140364192_140364343	0.39	ENSG00000252107	.	115564	0.07
chr10_33403329_33403717	0.39	ENSG00000263576	.	15959	0.23
chr3_37154604_37154755	0.39	ENSG00000206645	.	19954	0.15
chr2_73333310_73333461	0.39	RAB11FIP5	RAB11 family interacting protein 5 (class I)	6761	0.18
chr15_74493564_74493715	0.39	STRA6	stimulated by retinoic acid 6	1152	0.31
chr22_43709368_43709519	0.38	SCUBE1	signal peptide, CUB domain, EGF-like 1	29886	0.16
chr12_50696750_50697016	0.38	AC140061.12	Uncharacterized protein	6394	0.16
chr19_13127164_13127315	0.38	CTC-239J10.1		1914	0.18
chr15_48845807_48845958	0.38	FBN1	fibrillin 1	92036	0.08
chr12_93139497_93139648	0.38	PLEKHG7	pleckstrin homology domain containing, family G (with RhoGef domain) member 7	9261	0.24
chr15_78598378_78598529	0.38	WDR61	WD repeat domain 61	6317	0.13
chr16_53700893_53701044	0.38	RPGRIP1L	RPGRIP1-like	36754	0.17
chr2_12191853_12192027	0.38	ENSG00000238503	.	21442	0.26
chr16_70788132_70788283	0.38	VAC14-AS1	VAC14 antisense RNA 1	794	0.57
chr7_81254412_81254563	0.38	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	137825	0.05
chr17_70131143_70131294	0.38	SOX9	SRY (sex determining region Y)-box 9	14057	0.3
chr5_53843408_53843569	0.37	SNX18	sorting nexin 18	29895	0.23
chr15_59461408_59461559	0.37	ENSG00000253030	.	1978	0.21
chr4_3709443_3709594	0.37	ADRA2C	adrenoceptor alpha 2C	58557	0.14
chr7_55097499_55097650	0.37	EGFR	epidermal growth factor receptor	10763	0.3
chr7_134483017_134483168	0.37	CALD1	caldesmon 1	18663	0.27
chr19_41106420_41106924	0.37	LTBP4	latent transforming growth factor beta binding protein 4	605	0.65
chr11_118475244_118475483	0.37	PHLDB1	pleckstrin homology-like domain, family B, member 1	1792	0.23
chr7_107612741_107612892	0.37	ENSG00000238297	.	27611	0.14
chr1_95484423_95484574	0.37	RP11-313A24.1		42654	0.12
chr12_96040256_96040407	0.37	ENSG00000212448	.	28866	0.2
chr6_158838381_158838532	0.37	RP11-732M18.2		18863	0.2
chr6_107039846_107039997	0.37	ENSG00000200295	.	15670	0.17
chr6_143444127_143444389	0.37	AIG1	androgen-induced 1	3129	0.29
chr22_44453501_44453802	0.37	PARVB	parvin, beta	11290	0.25
chr2_232675645_232675796	0.37	RP11-690I21.2		1164	0.45
chr4_141177038_141177320	0.37	SCOC	short coiled-coil protein	1261	0.51
chr12_102821294_102821445	0.37	IGF1	insulin-like growth factor 1 (somatomedin C)	51060	0.17
chr2_46111015_46111315	0.36	PRKCE	protein kinase C, epsilon	116876	0.06
chr16_70672907_70673058	0.36	IL34	interleukin 34	7486	0.16
chr7_28076131_28076580	0.36	JAZF1	JAZF zinc finger 1	15937	0.26
chr11_123074983_123075134	0.36	CLMP	CXADR-like membrane protein	9069	0.2
chr13_50897665_50897816	0.36	ENSG00000221198	.	39633	0.21
chr15_93571206_93571357	0.36	CHD2	chromodomain helicase DNA binding protein 2	19185	0.22
chr6_133823044_133823328	0.36	RP3-323P13.2		9680	0.25
chr8_123101555_123101706	0.36	HAS2-AS1	HAS2 antisense RNA 1	447954	0.01
chr5_149539504_149539655	0.36	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	4156	0.17
chr18_42169234_42169525	0.36	SETBP1	SET binding protein 1	90759	0.1
chr15_50152532_50152683	0.36	ATP8B4	ATPase, class I, type 8B, member 4	16285	0.21
chr11_123060970_123061121	0.36	CTD-2216M2.1		1535	0.4
chr2_28884288_28884439	0.36	AC074011.2		3043	0.24
chr1_218549970_218550121	0.36	TGFB2	transforming growth factor, beta 2	30468	0.19
chr11_19983976_19984127	0.36	NAV2-AS3	NAV2 antisense RNA 3	18832	0.23
chr1_246024185_246024336	0.35	RP11-83A16.1		172593	0.03
chr2_189980501_189980652	0.35	ENSG00000264725	.	17261	0.2
chr10_79266628_79266779	0.35	ENSG00000199592	.	80104	0.1
chr22_27908632_27908783	0.35	RP11-375H17.1		203761	0.03
chr15_41335174_41335443	0.35	RP11-540O11.4		18611	0.14
chr9_91610255_91610406	0.35	S1PR3	sphingosine-1-phosphate receptor 3	1091	0.53
chr15_75993395_75993608	0.35	CSPG4	chondroitin sulfate proteoglycan 4	11688	0.09
chr17_79534584_79534839	0.35	NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	1050	0.34
chr2_62376728_62376879	0.35	AC018462.2		2787	0.26
chr1_212655450_212655601	0.35	NENF	neudesin neurotrophic factor	49296	0.12
chr9_94533727_94534271	0.35	ENSG00000266855	.	135466	0.05
chr11_28364524_28364785	0.35	ENSG00000222385	.	81588	0.11
chr1_159891458_159892260	0.35	TAGLN2	transgelin 2	1648	0.22
chr1_241645845_241645996	0.35	FH	fumarate hydratase	37141	0.18
chr10_33418933_33419614	0.34	ENSG00000263576	.	31709	0.18
chr6_5989927_5990321	0.34	NRN1	neuritin 1	17076	0.23
chr6_44041464_44042348	0.34	RP5-1120P11.1		483	0.79
chr20_17790847_17791092	0.34	ENSG00000221220	.	32258	0.18
chr7_78912243_78912394	0.34	ENSG00000212482	.	60370	0.15
chr6_75853034_75853185	0.34	COL12A1	collagen, type XII, alpha 1	8796	0.28
chr14_55120501_55120684	0.34	SAMD4A	sterile alpha motif domain containing 4A	85955	0.09
chr3_190812380_190812531	0.34	OSTN	osteocrin	104575	0.07
chr2_226989431_226989582	0.34	ENSG00000263363	.	534003	0.0
chr1_25132670_25132821	0.34	ENSG00000238482	.	28275	0.19
chr6_46214251_46214402	0.34	ENPP5	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	75618	0.1
chr7_91655297_91655448	0.34	AKAP9	A kinase (PRKA) anchor protein 9	44080	0.16
chr5_140887145_140887296	0.34	PCDHGC5	protocadherin gamma subfamily C, 5	18412	0.08
chr12_89842845_89842996	0.34	POC1B	POC1 centriolar protein B	48114	0.13
chr9_132379434_132379585	0.34	C9orf50	chromosome 9 open reading frame 50	3546	0.15
chr5_172225899_172226104	0.34	ENSG00000206741	.	18904	0.13
chr14_31559795_31560006	0.34	AP4S1	adaptor-related protein complex 4, sigma 1 subunit	24398	0.15
chr2_12957737_12958037	0.33	ENSG00000264370	.	80394	0.11
chr2_196978823_196978974	0.33	RP11-347P5.1		37089	0.15
chr7_116617261_116617412	0.33	AC106873.4	Uncharacterized protein	9810	0.14
chr6_8084010_8084161	0.33	EEF1E1	eukaryotic translation elongation factor 1 epsilon 1	13459	0.22
chr15_42444184_42444335	0.33	PLA2G4F	phospholipase A2, group IVF	4575	0.18
chr7_25887678_25887829	0.33	ENSG00000199085	.	101853	0.08
chr12_92594357_92594508	0.33	ENSG00000199895	.	30203	0.17
chr1_157969918_157970069	0.33	KIRREL	kin of IRRE like (Drosophila)	6558	0.23
chr5_168862994_168863145	0.33	ENSG00000206614	.	116384	0.06
chr9_118090029_118090180	0.33	DEC1	deleted in esophageal cancer 1	186007	0.03
chr10_79804314_79804465	0.33	RPS24	ribosomal protein S24	10748	0.22
chr6_39521887_39522038	0.33	KIF6	kinesin family member 6	42074	0.18
chr2_43497360_43497511	0.33	AC010883.5		40723	0.17
chr1_119544917_119545068	0.33	TBX15	T-box 15	12813	0.25
chr15_66212983_66213134	0.33	MEGF11	multiple EGF-like-domains 11	50500	0.12
chr2_182813224_182813375	0.32	SSFA2	sperm specific antigen 2	27966	0.17
chr22_39828056_39828207	0.32	MGAT3	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	25218	0.12
chr11_10351462_10351613	0.32	AMPD3	adenosine monophosphate deaminase 3	12319	0.16
chr16_20963780_20963931	0.32	LYRM1	LYR motif containing 1	51429	0.11
chr8_97603049_97603490	0.32	SDC2	syndecan 2	4654	0.31
chr10_101756595_101756746	0.32	DNMBP	dynamin binding protein	13006	0.18
chr12_63077564_63077715	0.32	ENSG00000238475	.	32684	0.17
chr19_13957559_13958184	0.32	ENSG00000207980	.	10398	0.08
chr9_15999494_15999645	0.32	C9orf92	chromosome 9 open reading frame 92	216328	0.02
chr1_18201641_18201961	0.32	ACTL8	actin-like 8	119993	0.06
chr5_169143698_169143935	0.32	DOCK2	dedicator of cytokinesis 2	12863	0.26
chr20_4044965_4045249	0.32	RP11-352D3.2	Uncharacterized protein	10705	0.22

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB18

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.1	0.2	GO:0071288	cellular response to mercury ion(GO:0071288)
0.1	0.4	GO:0060037	pharyngeal system development(GO:0060037)
0.1	0.2	GO:0030091	protein repair(GO:0030091)
0.1	0.2	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0035583	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.2	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.2	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.2	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.2	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.2	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.3	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.2	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.1	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.2	GO:0061001	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0033025	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.0	GO:0060900	embryonic camera-type eye formation(GO:0060900)
0.0	0.1	GO:1900078	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.1	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.2	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.1	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.2	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0048845	venous blood vessel morphogenesis(GO:0048845) venous blood vessel development(GO:0060841)
0.0	0.1	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.3	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0021508	floor plate formation(GO:0021508)
0.0	0.1	GO:0032966	negative regulation of collagen biosynthetic process(GO:0032966)
0.0	0.2	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.2	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.0	GO:0010713	negative regulation of collagen metabolic process(GO:0010713) negative regulation of multicellular organismal metabolic process(GO:0044252)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0035844	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.1	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.2	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.2	GO:0051957	positive regulation of amino acid transport(GO:0051957)
0.0	0.0	GO:0009261	ribonucleotide catabolic process(GO:0009261)
0.0	0.5	GO:0030835	negative regulation of actin filament depolymerization(GO:0030835)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.0	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.0	GO:2001279	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0019511	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0046325	negative regulation of glucose import(GO:0046325)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.0	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.1	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.0	0.1	GO:0034243	regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0035625	receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.2	GO:0045661	regulation of myoblast differentiation(GO:0045661)
0.0	0.0	GO:0046100	hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0	0.0	GO:0090244	Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0	0.1	GO:0061726	mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0	0.0	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.0	0.1	GO:0051593	response to folic acid(GO:0051593)
0.0	0.0	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	0.0	GO:0032610	interleukin-1 alpha production(GO:0032610)
0.0	0.2	GO:0030252	growth hormone secretion(GO:0030252)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.0	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.0	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.0	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.0	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.0	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.2	GO:0043277	apoptotic cell clearance(GO:0043277)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.0	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.0	GO:0072160	nephron tubule epithelial cell differentiation(GO:0072160) regulation of nephron tubule epithelial cell differentiation(GO:0072182) regulation of epithelial cell differentiation involved in kidney development(GO:2000696)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.0	GO:0072189	ureter development(GO:0072189)
0.0	0.1	GO:0031000	response to caffeine(GO:0031000)
0.0	0.0	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.0	GO:0017014	protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.0	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:0007008	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.0	GO:0014832	urinary bladder smooth muscle contraction(GO:0014832)
0.0	0.0	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.0	GO:0007262	STAT protein import into nucleus(GO:0007262)
0.0	0.1	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.1	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.0	GO:0019883	antigen processing and presentation of endogenous antigen(GO:0019883)
0.0	0.1	GO:0055012	ventricular cardiac muscle cell differentiation(GO:0055012)
0.0	0.3	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.0	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.0	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.0	GO:0032811	negative regulation of epinephrine secretion(GO:0032811)
0.0	0.0	GO:0045056	transcytosis(GO:0045056)
0.0	0.0	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0032770	positive regulation of monooxygenase activity(GO:0032770)
0.0	0.1	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.1	GO:0030219	megakaryocyte differentiation(GO:0030219)
0.0	0.0	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.0	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0010715	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.0	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.0	GO:0071043	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.0	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.0	GO:0010225	response to UV-C(GO:0010225)
0.0	0.0	GO:0003181	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	0.0	GO:0021978	telencephalon regionalization(GO:0021978)
0.0	0.0	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.0	GO:0035268	protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0	0.1	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0	0.1	GO:0006385	transcription elongation from RNA polymerase III promoter(GO:0006385) termination of RNA polymerase III transcription(GO:0006386)
0.0	0.1	GO:0000768	syncytium formation by plasma membrane fusion(GO:0000768) myoblast fusion(GO:0007520)
0.0	0.0	GO:0071223	response to lipoteichoic acid(GO:0070391) cellular response to lipoteichoic acid(GO:0071223)
0.0	0.0	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.0	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.1	GO:0098876	Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0	0.0	GO:1904181	positive regulation of mitochondrial depolarization(GO:0051901) positive regulation of membrane depolarization(GO:1904181)
0.0	0.0	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	0.2	GO:0007220	Notch receptor processing(GO:0007220)
0.0	0.2	GO:0007030	Golgi organization(GO:0007030)
0.0	0.0	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.1	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.1	GO:0051310	metaphase plate congression(GO:0051310)
0.0	0.0	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.0	GO:1903392	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.2	GO:0048179	activin receptor complex(GO:0048179)
0.1	0.2	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.3	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.2	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.2	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0030132	clathrin coat of coated pit(GO:0030132)
0.0	0.1	GO:0031904	endosome lumen(GO:0031904)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.2	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.1	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.0	GO:0042824	MHC class I peptide loading complex(GO:0042824)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0002102	podosome(GO:0002102)
0.0	0.0	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.0	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.1	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.0	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0098651	basement membrane collagen trimer(GO:0098651)
0.0	0.0	GO:0002178	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.0	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.0	GO:0033185	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.0	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.2	GO:0043195	terminal bouton(GO:0043195)
0.0	0.2	GO:0009925	basal plasma membrane(GO:0009925)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.1	0.2	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.2	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.3	GO:0035673	oligopeptide transmembrane transporter activity(GO:0035673)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.2	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.2	GO:0016847	1-aminocyclopropane-1-carboxylate synthase activity(GO:0016847)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.2	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.3	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.2	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.1	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.2	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.2	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.1	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.2	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.1	GO:0000828	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.0	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0004739	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.0	0.1	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.0	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.0	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.1	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.2	GO:0070888	E-box binding(GO:0070888)
0.0	0.0	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.0	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.0	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.0	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.1	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.2	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0	0.0	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.2	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.0	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0034416	bisphosphoglycerate phosphatase activity(GO:0034416)
0.0	0.0	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.4	GO:0005518	collagen binding(GO:0005518)
0.0	0.0	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0016413	O-acetyltransferase activity(GO:0016413)
0.0	0.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.0	GO:0060229	lipase activator activity(GO:0060229)
0.0	0.0	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.7	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.3	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.0	0.0	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.0	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.0	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.0	GO:0046848	hydroxyapatite binding(GO:0046848)
0.0	0.1	GO:0070717	poly-purine tract binding(GO:0070717)
0.0	0.1	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.1	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.1	GO:0016918	retinal binding(GO:0016918)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.0	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0005112	Notch binding(GO:0005112)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.8	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.8	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	PID S1P S1P1 PATHWAY	S1P1 pathway
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	PID RHOA PATHWAY	RhoA signaling pathway
0.7	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.2	PID ALK2 PATHWAY	ALK2 signaling events
0.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.2	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.1	PID FGF PATHWAY	FGF signaling pathway
0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.2	NABA COLLAGENS	Genes encoding collagen proteins
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.3	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.3	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.3	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.3	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.8	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.2	REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	Genes involved in Processive synthesis on the lagging strand
0.2	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.3	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation