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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for ZBTB3

Z-value: 1.91

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Transcription factors associated with ZBTB3

Gene Symbol	Gene ID	Gene Info
ZBTB3 Ensembl NCBI GeneCards UniProt	ENSG00000185670.7	zinc finger and BTB domain containing 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr11_62520042_62520272	ZBTB3	1474	0.153350	0.90	1.1e-03	Click!
chr11_62522278_62522445	ZBTB3	701	0.364975	0.81	8.7e-03	Click!
chr11_62520448_62520614	ZBTB3	1100	0.216190	0.69	4.0e-02	Click!
chr11_62516772_62516923	ZBTB3	4784	0.066489	0.65	6.1e-02	Click!
chr11_62520645_62521234	ZBTB3	692	0.371292	0.63	6.8e-02	Click!

Activity of the ZBTB3 motif across conditions

Conditions sorted by the z-value of the ZBTB3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_118072613_118072939	0.65	AMICA1	adhesion molecule, interacts with CXADR antigen 1	10824	0.14
chr2_143905750_143905972	0.61	ARHGAP15	Rho GTPase activating protein 15	18978	0.23
chrX_65233888_65234240	0.58	ENSG00000207939	.	4648	0.23
chr19_17515338_17515615	0.56	BST2	bone marrow stromal cell antigen 2	981	0.26
chr8_27141838_27142066	0.51	TRIM35	tripartite motif containing 35	9700	0.19
chr1_226913224_226913375	0.50	ITPKB	inositol-trisphosphate 3-kinase B	11860	0.22
chr16_68391010_68391249	0.50	SMPD3	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	13779	0.11
chr19_46062028_46062181	0.50	OPA3	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)	25973	0.09
chr1_168489861_168490042	0.49	XCL2	chemokine (C motif) ligand 2	23284	0.22
chr6_14661168_14661338	0.49	ENSG00000206960	.	14487	0.31
chr10_127476698_127477090	0.49	MMP21	matrix metallopeptidase 21	12504	0.12
chr21_47972699_47973025	0.48	ENSG00000272283	.	17153	0.17
chrX_153191071_153191365	0.48	ARHGAP4	Rho GTPase activating protein 4	480	0.63
chr9_130824645_130825193	0.46	NAIF1	nuclear apoptosis inducing factor 1	4681	0.11
chr10_116298480_116298654	0.46	ABLIM1	actin binding LIM protein 1	11877	0.27
chr15_69095617_69095778	0.45	ENSG00000265195	.	1433	0.47
chr10_11224083_11224251	0.45	RP3-323N1.2		10828	0.22
chr1_154374460_154374658	0.45	IL6R	interleukin 6 receptor	3110	0.17
chr1_29279854_29280083	0.44	ENSG00000206704	.	32254	0.15
chr7_38352706_38353008	0.44	STARD3NL	STARD3 N-terminal like	134860	0.05
chr6_11389498_11389649	0.44	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	6992	0.29
chr1_22365291_22365442	0.44	CDC42	cell division cycle 42	13754	0.1
chr10_11449968_11450254	0.44	CELF2-AS1	CELF2 antisense RNA 1	88264	0.09
chr12_53006435_53006586	0.43	RP11-641A6.2		1438	0.25
chr10_16784364_16784554	0.43	RP11-197M22.2		5917	0.3
chr14_102001489_102001687	0.43	ENSG00000258498	.	25171	0.17
chr16_29638484_29638656	0.42	ENSG00000266758	.	27984	0.11
chr2_233957752_233957956	0.42	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	32665	0.16
chr11_122540603_122540832	0.41	UBASH3B	ubiquitin associated and SH3 domain containing B	14334	0.23
chr6_130833278_130833537	0.41	ENSG00000202438	.	61850	0.12
chr6_7706604_7706755	0.41	BMP6	bone morphogenetic protein 6	20351	0.26
chr2_198066137_198066395	0.41	ANKRD44	ankyrin repeat domain 44	3504	0.25
chr8_144656219_144656478	0.41	RP11-661A12.9		688	0.35
chr3_46915049_46915349	0.40	PTH1R	parathyroid hormone 1 receptor	4037	0.16
chr6_149487995_149488146	0.40	ENSG00000263481	.	9860	0.23
chr17_66353157_66353348	0.40	ARSG	arylsulfatase G	65593	0.09
chr17_76121997_76122236	0.40	TMC6	transmembrane channel-like 6	985	0.4
chr5_58474357_58474721	0.40	PDE4D	phosphodiesterase 4D, cAMP-specific	97406	0.09
chr2_54818710_54819076	0.39	SPTBN1	spectrin, beta, non-erythrocytic 1	33362	0.15
chr3_169228382_169228591	0.39	RP11-641D5.2		62831	0.12
chr10_71258031_71258319	0.39	TSPAN15	tetraspanin 15	14551	0.21
chr14_21492164_21492434	0.39	NDRG2	NDRG family member 2	44	0.94
chr9_92022718_92022899	0.39	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	1967	0.41
chr7_45014027_45014264	0.39	MYO1G	myosin IG	4552	0.15
chr13_99873480_99873899	0.38	ENSG00000201793	.	15727	0.17
chr17_37929342_37929493	0.38	IKZF3	IKAROS family zinc finger 3 (Aiolos)	5061	0.15
chr2_114009637_114009821	0.38	ENSG00000189223	.	1386	0.36
chr10_22621203_22621416	0.38	BMI1	BMI1 polycomb ring finger oncogene	5861	0.16
chr15_91124919_91125154	0.38	CRTC3	CREB regulated transcription coactivator 3	11909	0.16
chr16_89786830_89787010	0.38	ZNF276	zinc finger protein 276	112	0.82
chr5_142601359_142601510	0.38	ARHGAP26	Rho GTPase activating protein 26	14669	0.24
chr1_110044414_110044707	0.38	AMIGO1	adhesion molecule with Ig-like domain 1	7744	0.1
chr22_25784690_25784862	0.38	LRP5L	low density lipoprotein receptor-related protein 5-like	7232	0.22
chr9_140535690_140535981	0.38	EHMT1	euchromatic histone-lysine N-methyltransferase 1	22381	0.12
chr5_156643181_156643332	0.38	CTB-4E7.1		8134	0.14
chr5_17401477_17401628	0.38	ENSG00000201715	.	55827	0.16
chr3_111838488_111838639	0.38	ENSG00000207940	.	6915	0.16
chr16_30465375_30465526	0.37	ENSG00000202476	.	32	0.93
chr1_175155591_175155923	0.37	KIAA0040	KIAA0040	6133	0.28
chr4_57162609_57162760	0.37	ENSG00000252489	.	7934	0.18
chr13_108978859_108979065	0.37	ENSG00000223177	.	25283	0.22
chr12_117505354_117505516	0.37	TESC	tescalcin	20799	0.23
chr16_85481767_85482285	0.37	ENSG00000264203	.	6928	0.27
chr11_121460015_121460221	0.37	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	1010	0.7
chr9_92114209_92114545	0.37	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	1332	0.39
chr6_6589667_6589818	0.37	LY86	lymphocyte antigen 86	840	0.64
chr15_38944558_38944900	0.37	C15orf53	chromosome 15 open reading frame 53	44070	0.17
chr16_66254914_66255088	0.37	ENSG00000201999	.	80711	0.1
chr5_54397274_54397694	0.37	GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	992	0.48
chr18_45693812_45693963	0.37	ZBTB7C	zinc finger and BTB domain containing 7C	1950	0.34
chr14_98640158_98640463	0.37	ENSG00000222066	.	157777	0.04
chr20_24930029_24930180	0.37	CST7	cystatin F (leukocystatin)	238	0.94
chr9_93623460_93623611	0.36	SYK	spleen tyrosine kinase	33765	0.25
chr7_105710995_105711146	0.36	SYPL1	synaptophysin-like 1	27238	0.22
chr21_35309542_35309837	0.36	LINC00649	long intergenic non-protein coding RNA 649	6171	0.17
chr16_21552669_21552820	0.36	ENSG00000265462	.	35288	0.11
chr8_29958239_29958543	0.36	LEPROTL1	leptin receptor overlapping transcript-like 1	1065	0.45
chr19_35657776_35658048	0.36	FXYD5	FXYD domain containing ion transport regulator 5	2974	0.14
chr8_66210609_66210785	0.36	ENSG00000200714	.	294269	0.01
chr3_18699709_18700035	0.36	ENSG00000228956	.	35507	0.24
chr3_187718083_187718321	0.36	LPP	LIM domain containing preferred translocation partner in lipoma	152870	0.04
chr1_40526792_40526943	0.36	CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	20313	0.16
chr3_114042663_114042814	0.36	ENSG00000207770	.	7322	0.18
chr12_47802229_47802503	0.36	ENSG00000264906	.	44314	0.16
chr8_22023106_22023363	0.35	BMP1	bone morphogenetic protein 1	434	0.71
chr9_140600192_140600440	0.35	EHMT1	euchromatic histone-lysine N-methyltransferase 1	86862	0.06
chr6_167039994_167040219	0.35	RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	619	0.81
chr5_49954046_49954253	0.35	PARP8	poly (ADP-ribose) polymerase family, member 8	7584	0.33
chr9_107746813_107746990	0.35	ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	56383	0.13
chr13_76603510_76603661	0.35	ENSG00000243274	.	105482	0.07
chr12_123592835_123592986	0.34	PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2	2065	0.32
chr16_50717313_50717932	0.34	SNX20	sorting nexin 20	2358	0.19
chr6_91182223_91182574	0.34	ENSG00000252676	.	25907	0.24
chr15_77305575_77305811	0.34	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	2459	0.29
chr9_117693028_117693209	0.34	TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	421	0.9
chr2_109760956_109761199	0.34	ENSG00000264934	.	3033	0.31
chr1_154385038_154385189	0.34	RP11-350G8.5		6073	0.14
chr7_144214916_144215067	0.34	ENSG00000221507	.	66217	0.11
chr11_82468391_82468542	0.34	FAM181B	family with sequence similarity 181, member B	23560	0.23
chr14_90088110_90088261	0.34	ENSG00000201027	.	77	0.96
chr10_7543332_7543483	0.34	ENSG00000207453	.	14636	0.22
chr8_66854346_66854497	0.34	DNAJC5B	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	79374	0.1
chr8_82087006_82087305	0.34	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	62852	0.13
chr19_13997160_13997334	0.34	C19orf57	chromosome 19 open reading frame 57	1946	0.16
chr11_128161211_128161582	0.33	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	213893	0.02
chr11_74972924_74973211	0.33	CTD-2562J17.7		1896	0.23
chr4_140613980_140614131	0.33	ENSG00000201533	.	7474	0.22
chr10_21811725_21811876	0.33	SKIDA1	SKI/DACH domain containing 1	2811	0.19
chr21_43812908_43813111	0.33	TMPRSS3	transmembrane protease, serine 3	3043	0.17
chr2_7568232_7568398	0.33	ENSG00000221255	.	148657	0.05
chr1_167682497_167682682	0.33	MPZL1	myelin protein zero-like 1	8598	0.24
chr16_85641538_85641689	0.33	GSE1	Gse1 coiled-coil protein	3402	0.27
chr20_58586774_58586925	0.33	CDH26	cadherin 26	15400	0.2
chr16_29752633_29752784	0.33	AC009133.17		3860	0.11
chr21_45370001_45370152	0.33	AGPAT3	1-acylglycerol-3-phosphate O-acyltransferase 3	492	0.79
chr10_73505463_73505770	0.33	C10orf105	chromosome 10 open reading frame 105	8035	0.2
chr8_35725858_35726009	0.33	AC012215.1	Uncharacterized protein	76568	0.12
chr15_41195981_41196229	0.33	VPS18	vacuolar protein sorting 18 homolog (S. cerevisiae)	9440	0.11
chr2_84725667_84725818	0.33	DNAH6	dynein, axonemal, heavy chain 6	17837	0.24
chr1_65528171_65528405	0.33	ENSG00000199135	.	4097	0.22
chr10_73845729_73845919	0.32	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	2262	0.36
chr8_70590129_70590280	0.32	ENSG00000222889	.	22255	0.21
chr3_30646654_30646841	0.32	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	1247	0.62
chr9_92057270_92057421	0.32	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	5947	0.27
chr19_2737260_2737411	0.32	SLC39A3	solute carrier family 39 (zinc transporter), member 3	2138	0.17
chr1_2058222_2058390	0.32	PRKCZ	protein kinase C, zeta	6771	0.15
chr9_117133277_117133577	0.31	AKNA	AT-hook transcription factor	5817	0.21
chrX_131161523_131161674	0.31	MST4	Serine/threonine-protein kinase MST4	3962	0.27
chr20_62219163_62219475	0.31	HELZ2	helicase with zinc finger 2, transcriptional coactivator	15511	0.09
chr7_127751189_127751374	0.31	ENSG00000207588	.	29368	0.19
chr4_148973748_148973899	0.31	RP11-76G10.1		93799	0.09
chr17_72474707_72474911	0.31	CD300A	CD300a molecule	11808	0.14
chr11_82462241_82462527	0.31	FAM181B	family with sequence similarity 181, member B	17478	0.25
chr3_52288594_52288804	0.31	PPM1M	protein phosphatase, Mg2+/Mn2+ dependent, 1M	5722	0.09
chr3_18597997_18598194	0.31	ENSG00000228956	.	29431	0.24
chr2_86811496_86811732	0.31	ENSG00000252453	.	1649	0.3
chr7_50325061_50325347	0.31	IKZF1	IKAROS family zinc finger 1 (Ikaros)	19120	0.26
chr17_36811230_36811381	0.31	C17orf96	chromosome 17 open reading frame 96	19882	0.09
chr1_1105451_1105692	0.31	ENSG00000198976	.	1186	0.23
chr3_183273797_183274296	0.31	KLHL6	kelch-like family member 6	569	0.74
chr17_74198396_74198547	0.31	RNF157	ring finger protein 157	35308	0.1
chr9_36128064_36128590	0.31	GLIPR2	GLI pathogenesis-related 2	8405	0.2
chr6_159516563_159516714	0.31	TAGAP	T-cell activation RhoGTPase activating protein	50454	0.12
chr4_37781564_37781825	0.31	PGM2	phosphoglucomutase 2	46561	0.16
chr19_55009447_55009893	0.31	LAIR2	leukocyte-associated immunoglobulin-like receptor 2	570	0.6
chr19_30167962_30168113	0.31	PLEKHF1	pleckstrin homology domain containing, family F (with FYVE domain) member 1	10256	0.22
chr8_21754699_21754946	0.31	DOK2	docking protein 2, 56kDa	16352	0.18
chr11_128598285_128598783	0.31	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	32616	0.15
chr2_231527868_231528072	0.31	CAB39	calcium binding protein 39	49590	0.13
chr19_47998683_47998834	0.31	NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	5248	0.14
chr14_56681569_56681720	0.31	PELI2	pellino E3 ubiquitin protein ligase family member 2	95817	0.08
chr11_48041048_48041486	0.30	AC103828.1		3860	0.26
chr7_55653076_55653289	0.30	RP11-310H4.1		12318	0.21
chr3_113283687_113283838	0.30	SIDT1-AS1	SIDT1 antisense RNA 1	25274	0.14
chr5_102201968_102202195	0.30	PAM	peptidylglycine alpha-amidating monooxygenase	261	0.96
chr3_193974434_193974585	0.30	CPN2	carboxypeptidase N, polypeptide 2	97538	0.06
chr20_62488359_62488510	0.30	ABHD16B	abhydrolase domain containing 16B	4132	0.09
chr10_8481047_8481211	0.30	ENSG00000212505	.	217665	0.02
chr13_103451962_103452202	0.30	BIVM	basic, immunoglobulin-like variable motif containing	521	0.5
chr9_34364123_34364401	0.30	KIAA1161	KIAA1161	8568	0.12
chr12_105085856_105086193	0.30	ENSG00000264295	.	100613	0.07
chr14_25168542_25168771	0.30	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	65183	0.1
chr15_66121309_66121502	0.30	ENSG00000252715	.	14417	0.17
chr7_37461432_37461682	0.30	ENSG00000200113	.	2326	0.3
chr16_11600909_11601081	0.30	CTD-3088G3.8	Protein LOC388210	15384	0.14
chr9_134852806_134853110	0.30	MED27	mediator complex subunit 27	102295	0.07
chr9_117152387_117152569	0.30	AKNA	AT-hook transcription factor	2117	0.33
chr15_52026637_52027130	0.30	LYSMD2	LysM, putative peptidoglycan-binding, domain containing 2	3435	0.18
chr3_72422070_72422221	0.30	RYBP	RING1 and YY1 binding protein	73924	0.12
chr6_141645569_141645720	0.30	ENSG00000222764	.	161905	0.04
chr9_93588989_93589216	0.30	SYK	spleen tyrosine kinase	668	0.83
chr13_100071950_100072184	0.30	ENSG00000266207	.	33656	0.15
chr12_12100011_12100162	0.30	ETV6	ets variant 6	61215	0.14
chr1_214484003_214484288	0.30	SMYD2	SET and MYND domain containing 2	20175	0.24
chr3_71451560_71451730	0.30	FOXP1	forkhead box P1	97734	0.08
chr5_169702138_169702842	0.30	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	8159	0.23
chr8_8255787_8255938	0.30	SGK223	Tyrosine-protein kinase SgK223	11854	0.27
chr14_103852606_103852757	0.29	MARK3	MAP/microtubule affinity-regulating kinase 3	105	0.96
chr2_173297425_173297752	0.29	AC078883.4		4257	0.21
chr7_5572884_5573049	0.29	ACTB	actin, beta	2626	0.18
chr17_75662489_75662681	0.29	SEPT9	septin 9	184590	0.03
chr7_110726767_110726918	0.29	LRRN3	leucine rich repeat neuronal 3	4220	0.29
chr17_19031965_19032258	0.29	GRAPL	GRB2-related adaptor protein-like	1263	0.26
chr17_61504750_61504945	0.29	RP11-269G24.3		3603	0.16
chr6_159482432_159482616	0.29	TAGAP	T-cell activation RhoGTPase activating protein	16340	0.19
chr8_27224770_27225112	0.29	PTK2B	protein tyrosine kinase 2 beta	13227	0.22
chr10_135054594_135055053	0.29	VENTX	VENT homeobox	3915	0.13
chr11_969980_970177	0.29	ENSG00000264671	.	18714	0.11
chr2_38881243_38881741	0.29	GALM	galactose mutarotase (aldose 1-epimerase)	11560	0.17
chr8_135047245_135047396	0.29	ENSG00000212273	.	390352	0.01
chr22_41497815_41497993	0.29	ENSG00000221160	.	9387	0.13
chr22_23162155_23162691	0.29	IGLV3-9	immunoglobulin lambda variable 3-9 (gene/pseudogene)	916	0.22
chr4_153106598_153106749	0.29	ENSG00000266244	.	42947	0.18
chr2_231530671_231530822	0.29	CAB39	calcium binding protein 39	46814	0.14
chr8_72091012_72091163	0.29	RP11-326E22.1		23330	0.27
chr2_43363342_43363671	0.29	ENSG00000207087	.	44874	0.17
chr13_110383641_110384047	0.29	LINC00676	long intergenic non-protein coding RNA 676	3215	0.35
chr14_21250121_21250386	0.28	RNASE6	ribonuclease, RNase A family, k6	1043	0.34
chr1_108349927_108350218	0.28	ENSG00000265536	.	31194	0.21
chr8_21771621_21771772	0.28	DOK2	docking protein 2, 56kDa	325	0.89

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0032632	interleukin-3 production(GO:0032632)
0.1	0.3	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.8	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.1	0.3	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.1	0.7	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.2	GO:0044266	multicellular organismal protein catabolic process(GO:0044254) protein digestion(GO:0044256) multicellular organismal macromolecule catabolic process(GO:0044266) multicellular organismal protein metabolic process(GO:0044268)
0.1	0.2	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.3	GO:0000089	mitotic metaphase(GO:0000089)
0.1	0.4	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.1	0.2	GO:0048388	endosomal lumen acidification(GO:0048388)
0.1	0.2	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1	0.1	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.1	0.3	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.2	GO:0060437	lung growth(GO:0060437)
0.1	0.2	GO:0045990	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.1	0.3	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1	0.2	GO:0010536	regulation of activation of Janus kinase activity(GO:0010533) positive regulation of activation of Janus kinase activity(GO:0010536)
0.1	0.2	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.1	0.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.2	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.1	0.2	GO:0031062	positive regulation of histone methylation(GO:0031062)
0.1	0.4	GO:0030851	granulocyte differentiation(GO:0030851)
0.1	0.2	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.2	GO:0032753	positive regulation of interleukin-4 production(GO:0032753)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.2	GO:0046618	drug export(GO:0046618)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.1	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.3	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.4	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.1	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.1	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0	0.2	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.2	GO:0090030	regulation of steroid hormone biosynthetic process(GO:0090030)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0	0.1	GO:0045588	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.0	0.2	GO:0090192	regulation of glomerulus development(GO:0090192)
0.0	0.6	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.2	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.2	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.1	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0030186	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.5	GO:0032613	interleukin-10 production(GO:0032613)
0.0	0.1	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.0	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.0	0.3	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.3	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.0	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.1	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0015809	arginine transport(GO:0015809)
0.0	0.2	GO:0097384	cellular lipid biosynthetic process(GO:0097384)
0.0	0.1	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:0009133	nucleoside diphosphate biosynthetic process(GO:0009133)
0.0	0.1	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664)
0.0	0.0	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.2	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.2	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.5	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.1	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.1	GO:0031065	regulation of histone deacetylation(GO:0031063) positive regulation of histone deacetylation(GO:0031065)
0.0	0.2	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.0	GO:0071503	response to heparin(GO:0071503)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.1	GO:0017085	response to insecticide(GO:0017085)
0.0	0.0	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.1	GO:0014805	smooth muscle adaptation(GO:0014805)
0.0	0.2	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.2	GO:0060347	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.2	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.0	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.0	0.2	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.1	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.1	GO:0009151	purine deoxyribonucleotide metabolic process(GO:0009151) purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0	0.1	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.0	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.4	GO:0046627	negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0	0.1	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0046874	quinolinate metabolic process(GO:0046874)
0.0	0.1	GO:0072178	nephric duct morphogenesis(GO:0072178)
0.0	0.1	GO:0015904	tetracycline transport(GO:0015904)
0.0	0.1	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0034085	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.2	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.1	GO:0031167	rRNA methylation(GO:0031167)
0.0	0.4	GO:0006825	copper ion transport(GO:0006825)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0045007	depurination(GO:0045007)
0.0	0.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.1	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.2	GO:0006287	base-excision repair, gap-filling(GO:0006287)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0031943	regulation of glucocorticoid metabolic process(GO:0031943)
0.0	0.2	GO:0061462	protein targeting to lysosome(GO:0006622) protein targeting to vacuole(GO:0006623) protein localization to lysosome(GO:0061462) protein localization to vacuole(GO:0072665) establishment of protein localization to vacuole(GO:0072666)
0.0	0.1	GO:0031442	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.0	GO:0042492	gamma-delta T cell differentiation(GO:0042492)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0060219	camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0	0.0	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.0	0.1	GO:0046502	uroporphyrinogen III metabolic process(GO:0046502)
0.0	0.1	GO:0085029	extracellular matrix assembly(GO:0085029)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.2	GO:0006265	DNA topological change(GO:0006265)
0.0	0.2	GO:0032367	intracellular sterol transport(GO:0032366) intracellular cholesterol transport(GO:0032367)
0.0	0.1	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.3	GO:0015939	pantothenate metabolic process(GO:0015939)
0.0	0.0	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.0	GO:0071698	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:1901985	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.0	GO:0001865	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.0	GO:0052251	induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.1	GO:0003085	negative regulation of systemic arterial blood pressure(GO:0003085)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0014888	striated muscle adaptation(GO:0014888)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.2	GO:0019317	fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0	0.0	GO:0002248	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.0	GO:0002475	antigen processing and presentation via MHC class Ib(GO:0002475)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.0	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.1	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.1	GO:0003077	obsolete negative regulation of diuresis(GO:0003077)
0.0	0.7	GO:0050772	positive regulation of axonogenesis(GO:0050772)
0.0	0.1	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.1	GO:0003159	morphogenesis of an endothelium(GO:0003159)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.0	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0	0.1	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.0	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.2	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	0.0	GO:2001012	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.0	GO:0045423	regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.0	0.1	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.1	GO:0015872	dopamine transport(GO:0015872)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0043129	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.1	GO:0009405	pathogenesis(GO:0009405)
0.0	0.0	GO:0014889	muscle atrophy(GO:0014889)
0.0	0.1	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.0	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.1	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.1	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.2	GO:0035116	embryonic hindlimb morphogenesis(GO:0035116)
0.0	0.1	GO:0090026	regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.1	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.0	0.1	GO:0031394	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.3	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0031663	lipopolysaccharide-mediated signaling pathway(GO:0031663)
0.0	0.1	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:0015884	folic acid transport(GO:0015884)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0042094	interleukin-2 biosynthetic process(GO:0042094)
0.0	0.2	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.3	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	0.1	GO:0046685	response to arsenic-containing substance(GO:0046685)
0.0	0.2	GO:0061036	positive regulation of cartilage development(GO:0061036)
0.0	0.1	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.0	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.0	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.1	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.9	GO:0050851	antigen receptor-mediated signaling pathway(GO:0050851)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.1	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.0	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.0	GO:0071428	rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0	0.0	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.1	GO:0031648	protein destabilization(GO:0031648)
0.0	0.0	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.2	GO:0014046	dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0	0.1	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.0	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.1	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.0	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.0	GO:0032849	positive regulation of cellular pH reduction(GO:0032849)
0.0	0.0	GO:0032971	regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.0	0.0	GO:0032203	telomere formation via telomerase(GO:0032203)
0.0	0.0	GO:0007341	penetration of zona pellucida(GO:0007341)
0.0	0.1	GO:0009820	alkaloid metabolic process(GO:0009820)
0.0	0.2	GO:0070664	negative regulation of leukocyte proliferation(GO:0070664)
0.0	0.1	GO:0031650	regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.0	GO:2000980	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.0	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.0	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.2	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.0	GO:0014741	negative regulation of cardiac muscle hypertrophy(GO:0010614) negative regulation of muscle hypertrophy(GO:0014741)
0.0	0.2	GO:0031670	cellular response to nutrient(GO:0031670)
0.0	0.0	GO:0030825	positive regulation of cGMP metabolic process(GO:0030825) positive regulation of cGMP biosynthetic process(GO:0030828)
0.0	0.0	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.0	GO:0060292	long term synaptic depression(GO:0060292)
0.0	0.0	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.0	0.0	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.0	GO:0010746	regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.0	GO:0042362	fat-soluble vitamin biosynthetic process(GO:0042362)
0.0	0.1	GO:0000076	DNA replication checkpoint(GO:0000076)
0.0	0.1	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.0	GO:0034122	negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0	0.0	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0	0.1	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.0	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.0	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.0	GO:0032025	response to cobalt ion(GO:0032025)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0060396	growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0	0.0	GO:0045359	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0	0.2	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.0	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.4	GO:0043484	regulation of RNA splicing(GO:0043484)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0033005	positive regulation of mast cell activation(GO:0033005)
0.0	0.1	GO:0032715	negative regulation of interleukin-6 production(GO:0032715)
0.0	0.1	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.2	GO:0045730	respiratory burst(GO:0045730)
0.0	0.2	GO:0050771	negative regulation of axonogenesis(GO:0050771)
0.0	0.0	GO:0002507	tolerance induction(GO:0002507)
0.0	0.0	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.1	GO:0006657	CDP-choline pathway(GO:0006657)
0.0	0.1	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0	0.1	GO:0000098	sulfur amino acid catabolic process(GO:0000098)
0.0	0.1	GO:0060765	regulation of androgen receptor signaling pathway(GO:0060765)
0.0	0.0	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0006000	fructose metabolic process(GO:0006000)
0.0	0.0	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.0	GO:0072074	kidney mesenchyme development(GO:0072074) metanephric mesenchyme development(GO:0072075)
0.0	0.0	GO:0061387	regulation of extent of cell growth(GO:0061387)
0.0	0.0	GO:0046968	peptide antigen transport(GO:0046968)
0.0	0.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.1	GO:0045006	DNA deamination(GO:0045006)
0.0	0.1	GO:0009650	UV protection(GO:0009650)
0.0	0.1	GO:0048873	homeostasis of number of cells within a tissue(GO:0048873)
0.0	0.1	GO:0008347	glial cell migration(GO:0008347)
0.0	0.1	GO:1903307	positive regulation of regulated secretory pathway(GO:1903307)
0.0	0.0	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.0	GO:0040009	regulation of growth rate(GO:0040009)
0.0	0.1	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.1	GO:0045161	neuronal ion channel clustering(GO:0045161)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.3	GO:0000080	mitotic G1 phase(GO:0000080)
0.0	0.1	GO:0042438	melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438)
0.0	0.0	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.0	GO:0014826	vein smooth muscle contraction(GO:0014826)
0.0	0.2	GO:0090174	organelle membrane fusion(GO:0090174)
0.0	0.1	GO:0031272	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.2	GO:0009309	amine biosynthetic process(GO:0009309)
0.0	0.0	GO:0030146	obsolete diuresis(GO:0030146)
0.0	0.0	GO:0008291	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.1	GO:0042226	interleukin-6 biosynthetic process(GO:0042226)
0.0	0.0	GO:0048679	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.0	GO:0021799	cerebral cortex radially oriented cell migration(GO:0021799)
0.0	0.0	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.0	0.2	GO:0060330	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.0	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.0	GO:0009698	phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804)
0.0	0.0	GO:0035376	sterol import(GO:0035376) cholesterol import(GO:0070508)
0.0	0.0	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.1	GO:0032528	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.5	GO:0002224	toll-like receptor signaling pathway(GO:0002224)
0.0	0.0	GO:0090598	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0	0.0	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0032212	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.0	GO:0051775	response to redox state(GO:0051775)
0.0	0.0	GO:0035095	behavioral response to nicotine(GO:0035095)
0.0	0.0	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.0	0.0	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.0	GO:0032770	positive regulation of monooxygenase activity(GO:0032770)
0.0	0.1	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.0	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.0	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0046040	IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.0	0.0	GO:0035269	protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0	0.1	GO:0019042	viral latency(GO:0019042)
0.0	0.1	GO:0009303	rRNA transcription(GO:0009303)
0.0	0.0	GO:0045655	regulation of monocyte differentiation(GO:0045655)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.1	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.0	0.1	GO:0051001	negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0	0.1	GO:0010921	regulation of phosphatase activity(GO:0010921) regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0	0.0	GO:0019228	neuronal action potential(GO:0019228)
0.0	0.0	GO:0010586	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.0	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.0	GO:0010823	negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0	0.0	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.0	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.0	GO:0016265	obsolete death(GO:0016265)
0.0	0.0	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.1	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.2	GO:0016574	histone ubiquitination(GO:0016574)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.1	GO:0018214	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.1	GO:0009595	detection of biotic stimulus(GO:0009595)
0.0	0.0	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.1	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.0	0.1	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.0	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.2	GO:0044036	cell wall macromolecule catabolic process(GO:0016998) cell wall macromolecule metabolic process(GO:0044036) cell wall organization or biogenesis(GO:0071554)
0.0	0.1	GO:0010890	positive regulation of sequestering of triglyceride(GO:0010890)
0.0	0.1	GO:0043249	erythrocyte maturation(GO:0043249)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.3	GO:0005826	actomyosin contractile ring(GO:0005826)
0.1	0.8	GO:0042101	T cell receptor complex(GO:0042101)
0.1	0.2	GO:0032009	early phagosome(GO:0032009)
0.1	0.2	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1	0.6	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.2	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.4	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.4	GO:0001772	immunological synapse(GO:0001772)
0.0	0.5	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.2	GO:0030681	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0	0.1	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.2	GO:0000791	euchromatin(GO:0000791)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.2	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0042583	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.4	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.2	GO:0045239	tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0	0.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.2	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.0	GO:0038201	TORC1 complex(GO:0031931) TOR complex(GO:0038201)
0.0	0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.2	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	0.2	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.2	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	1.3	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.0	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	0.3	GO:0032420	stereocilium(GO:0032420)
0.0	1.2	GO:0005643	nuclear pore(GO:0005643)
0.0	0.4	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.2	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.3	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.2	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.1	GO:0043209	myelin sheath(GO:0043209)
0.0	0.2	GO:0030914	STAGA complex(GO:0030914)
0.0	0.1	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.0	GO:0044462	external encapsulating structure(GO:0030312) external encapsulating structure part(GO:0044462)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.0	GO:0016589	NURF complex(GO:0016589)
0.0	0.2	GO:0030897	HOPS complex(GO:0030897)
0.0	0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.2	GO:0043596	nuclear replication fork(GO:0043596)
0.0	0.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.1	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0000109	nucleotide-excision repair complex(GO:0000109)
0.0	0.0	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.5	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.1	GO:0017071	intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0	0.6	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	0.0	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.5	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.0	GO:0008537	proteasome activator complex(GO:0008537)
0.0	0.0	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.0	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	0.0	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.2	GO:0016328	lateral plasma membrane(GO:0016328)
0.0	0.1	GO:0090576	RNA polymerase III transcription factor complex(GO:0090576)
0.0	0.6	GO:0031902	late endosome membrane(GO:0031902)
0.0	0.0	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.1	GO:0005682	U5 snRNP(GO:0005682)
0.0	0.0	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.0	GO:0033185	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0001741	XY body(GO:0001741)
0.0	0.4	GO:0030175	filopodium(GO:0030175)
0.0	0.0	GO:0070552	BRISC complex(GO:0070552)
0.0	0.0	GO:0000124	SAGA complex(GO:0000124)
0.0	0.1	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.0	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.0	GO:0000407	pre-autophagosomal structure(GO:0000407)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0016842	amidine-lyase activity(GO:0016842)
0.1	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.3	GO:0070492	oligosaccharide binding(GO:0070492)
0.1	0.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	0.2	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.1	0.1	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.1	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.1	0.2	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.1	0.2	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1	0.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	0.2	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1	0.2	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.1	0.2	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.1	0.6	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1	0.2	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.1	0.2	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1	0.3	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.2	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.0	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.2	GO:0016997	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0	0.1	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.3	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.4	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.6	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	1.8	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.2	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.2	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.5	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.0	0.1	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0004476	mannose-6-phosphate isomerase activity(GO:0004476)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.2	GO:0004457	lactate dehydrogenase activity(GO:0004457)
0.0	0.1	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0016715	dopamine beta-monooxygenase activity(GO:0004500) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.3	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.3	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.2	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.4	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.2	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.2	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.5	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.4	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0	0.1	GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0	0.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.2	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.1	GO:0003701	obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0	0.1	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.2	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.2	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.7	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0030343	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.4	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.2	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.1	GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0	0.1	GO:0004396	hexokinase activity(GO:0004396)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.2	GO:0003840	gamma-glutamyltransferase activity(GO:0003840)
0.0	0.1	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.2	GO:0071617	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.1	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.2	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.2	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.0	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.1	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.5	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)
0.0	0.1	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.3	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.2	GO:0015248	sterol transporter activity(GO:0015248)
0.0	0.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0008079	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.1	GO:0033612	receptor serine/threonine kinase binding(GO:0033612)
0.0	0.2	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.1	GO:0003964	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0	0.1	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.0	0.1	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.2	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.0	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.0	GO:0042806	fucose binding(GO:0042806)
0.0	0.1	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.2	GO:0004522	ribonuclease A activity(GO:0004522)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.2	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.0	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0046625	sphingolipid binding(GO:0046625)
0.0	0.0	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.2	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.2	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.2	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.2	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.2	GO:0033549	MAP kinase phosphatase activity(GO:0033549)
0.0	0.2	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	0.2	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.0	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.0	GO:0070735	protein-glycine ligase activity(GO:0070735)
0.0	0.2	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.0	GO:0031014	troponin T binding(GO:0031014)
0.0	0.0	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.0	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.0	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.4	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	0.2	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.3	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0016307	phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.0	GO:0016019	N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)
0.0	0.1	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.0	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.2	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.0	0.1	GO:0004415	hyalurononglucosaminidase activity(GO:0004415)
0.0	0.2	GO:0033558	histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.4	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.0	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.1	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.2	GO:0003727	single-stranded RNA binding(GO:0003727)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0001530	lipopolysaccharide binding(GO:0001530)
0.0	0.1	GO:0070717	poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.0	0.0	GO:0043139	5'-3' DNA helicase activity(GO:0043139)
0.0	0.0	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.0	GO:1901567	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.2	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.3	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0	0.1	GO:0008967	phosphoglycolate phosphatase activity(GO:0008967)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.0	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.0	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.0	GO:0008469	histone-arginine N-methyltransferase activity(GO:0008469)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.3	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.0	0.1	GO:0004551	nucleotide diphosphatase activity(GO:0004551)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.0	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.2	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.0	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.0	GO:0004802	transketolase activity(GO:0004802)
0.0	0.0	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.0	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.0	0.0	GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0	0.1	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.0	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.0	GO:0001733	galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0	0.1	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.0	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.1	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.0	GO:0016530	metallochaperone activity(GO:0016530)
0.0	0.1	GO:0004448	isocitrate dehydrogenase activity(GO:0004448)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.0	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.0	0.4	GO:0004879	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0	0.0	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.0	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.0	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.2	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.1	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.0	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0004950	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.0	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0	0.0	GO:0005497	androgen binding(GO:0005497)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	0.8	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.7	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.9	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	1.9	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	1.2	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.2	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.0	0.8	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.6	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	1.0	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.5	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.5	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.0	0.0	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	0.4	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	0.1	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	0.4	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	0.0	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.1	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.0	0.0	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	0.3	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.5	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.7	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	0.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.0	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.2	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.2	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.5	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.2	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.1	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.3	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.0	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0	0.2	PID IL23 PATHWAY	IL23-mediated signaling events
0.0	0.1	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.2	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	0.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	0.2	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.1	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.0	0.2	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	0.1	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	0.0	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.0	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.4	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.0	0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.2	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	0.3	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.0	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	0.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	0.1	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	0.6	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	0.1	PID IL12 2PATHWAY	IL12-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.1	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1	1.0	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.4	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.7	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.5	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.2	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	0.4	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.9	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.2	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.4	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.4	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0	0.4	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.6	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.3	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.1	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.4	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.3	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.3	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.3	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	1.5	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.0	0.0	REACTOME PKB MEDIATED EVENTS	Genes involved in PKB-mediated events
0.0	0.0	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.2	REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	Genes involved in Integrin alphaIIb beta3 signaling
0.0	0.1	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.3	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.1	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.6	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	0.0	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.4	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.3	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.2	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.6	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.6	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	0.2	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.2	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.5	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.0	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0	0.1	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.9	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.6	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.3	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.4	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.2	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.0	0.1	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0	0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.2	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	0.3	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.0	0.2	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.2	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.3	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.0	0.4	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	0.2	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.3	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.0	REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	Genes involved in Signaling by the B Cell Receptor (BCR)
0.0	0.0	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	0.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.0	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.4	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0	0.1	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.3	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.1	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.1	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.3	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.2	REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0	0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.0	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0	0.3	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.1	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.1	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.2	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.7	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.2	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.0	0.5	REACTOME TOLL RECEPTOR CASCADES	Genes involved in Toll Receptor Cascades
0.0	0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.1	REACTOME RNA POL I TRANSCRIPTION INITIATION	Genes involved in RNA Polymerase I Transcription Initiation
0.0	0.2	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.1	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.5	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	0.1	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.0	REACTOME CA DEPENDENT EVENTS	Genes involved in Ca-dependent events
0.0	0.0	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.1	REACTOME OPSINS	Genes involved in Opsins

Results for ZBTB3

Z-value: 1.91

Motif logo

Transcription factors associated with ZBTB3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the ZBTB3 motif across conditions

Conditions sorted by the z-value of the ZBTB3 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: