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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for ZBTB49

Z-value: 1.87

Motif logo

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Transcription factors associated with ZBTB49

Gene Symbol Gene ID Gene Info
ZBTB49
ENSG00000168826.11 zinc finger and BTB domain containing 49

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr4_4311282_4311433ZBTB4970030.189887-0.761.7e-02Click!
chr4_4310564_4310715ZBTB4962850.193270-0.684.4e-02Click!
chr4_4310239_4310390ZBTB4959600.195151-0.665.4e-02Click!
chr4_4293176_4293389ZBTB4912860.3418670.561.2e-01Click!
chr4_4292418_4292569ZBTB494970.5150060.541.4e-01Click!

Activity of the ZBTB49 motif across conditions

Conditions sorted by the z-value of the ZBTB49 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr14_35591551_35591702 0.91 PPP2R3C
 protein phosphatase 2, regulatory subunit B'', gamma
 53
 0.58
chr5_65440945_65441096 0.89 SREK1
 splicing regulatory glutamine/lysine-rich protein 1
 357
 0.52
chr1_197879321_197879472 0.77 LHX9
 LIM homeobox 9
 2225
 0.36
chr11_122714029_122714331 0.76 CRTAM
 cytotoxic and regulatory T cell molecule
 4972
 0.24
chr3_194023502_194023858 0.76 CPN2
 carboxypeptidase N, polypeptide 2
 48367
 0.13
chr1_9764053_9764209 0.74 PIK3CD
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
 6125
 0.18
chr14_89913899_89914115 0.72 FOXN3-AS1
 FOXN3 antisense RNA 1
 30309
 0.15
chr1_157819053_157819204 0.72 CD5L
 CD5 molecule-like
 7540
 0.21
chr12_47756185_47756391 0.71 ENSG00000264906
 .
 1764
 0.4
chr5_176787986_176788182 0.70 RGS14
 regulator of G-protein signaling 14
 3246
 0.13
chr9_134377992_134378202 0.70 POMT1
 protein-O-mannosyltransferase 1
 192
 0.92
chr15_101061308_101061579 0.69 CERS3
 ceramide synthase 3
 23033
 0.14
chr5_66118075_66118363 0.68 MAST4
 microtubule associated serine/threonine kinase family member 4
 6383
 0.33
chr2_220112096_220112414 0.66 STK16
 serine/threonine kinase 16
 1637
 0.15
chr12_11699871_11700022 0.66 ENSG00000251747
 .
 533
 0.78
chr17_3818792_3818943 0.65 P2RX1
 purinergic receptor P2X, ligand-gated ion channel, 1
 927
 0.52
chr19_8570015_8570216 0.65 PRAM1
 PML-RARA regulated adaptor molecule 1
 2119
 0.2
chr6_121758459_121758727 0.65 GJA1
 gap junction protein, alpha 1, 43kDa
 1755
 0.35
chr7_3108313_3108464 0.65 CARD11
 caspase recruitment domain family, member 11
 24809
 0.21
chr1_26869946_26870282 0.64 RPS6KA1
 ribosomal protein S6 kinase, 90kDa, polypeptide 1
 511
 0.72
chr5_169698686_169698837 0.64 LCP2
 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
 4430
 0.26
chr19_14464423_14464642 0.63 CD97
 CD97 molecule
 27436
 0.13
chr3_20084242_20084393 0.63 KAT2B
 K(lysine) acetyltransferase 2B
 2802
 0.27
chr11_46371500_46371856 0.62 DGKZ
 diacylglycerol kinase, zeta
 2540
 0.22
chr1_182558263_182558414 0.62 RNASEL
 ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
 53
 0.98
chr1_154988213_154988563 0.61 ZBTB7B
 zinc finger and BTB domain containing 7B
 1464
 0.18
chr4_40207735_40207928 0.60 RHOH
 ras homolog family member H
 5867
 0.23
chr4_8173290_8173441 0.60 SH3TC1
 SH3 domain and tetratricopeptide repeats 1
 10437
 0.21
chr22_50752388_50752886 0.60 XX-C283C717.1
423
 0.69
chrX_9542077_9542228 0.60 TBL1X
 transducin (beta)-like 1X-linked
 39169
 0.22
chr17_74028313_74028464 0.59 EVPL
 envoplakin
 4855
 0.12
chr12_105085856_105086193 0.59 ENSG00000264295
 .
 100613
 0.07
chr3_31274169_31274365 0.59 ENSG00000222983
 .
 4060
 0.33
chr16_50309977_50310263 0.59 ADCY7
 adenylate cyclase 7
 2056
 0.34
chr11_47237830_47237981 0.59 DDB2
 damage-specific DNA binding protein 2, 48kDa
 1412
 0.25
chr12_65176538_65176711 0.59 TBC1D30
 TBC1 domain family, member 30
 1650
 0.32
chr7_26373644_26373838 0.59 SNX10
 sorting nexin 10
 19936
 0.21
chr16_2918250_2918510 0.58 PRSS22
 protease, serine, 22
 10209
 0.08
chr17_7308499_7308674 0.58 NLGN2
 neuroligin 2
 393
 0.52
chr20_61604608_61604759 0.58 SLC17A9
 solute carrier family 17 (vesicular nucleotide transporter), member 9
 20285
 0.14
chr2_233186649_233186800 0.57 DIS3L2
 DIS3 mitotic control homolog (S. cerevisiae)-like 2
 11929
 0.18
chr2_198126272_198126712 0.57 ANKRD44-IT1
 ANKRD44 intronic transcript 1 (non-protein coding)
 40751
 0.13
chr3_183208611_183208762 0.57 ENSG00000251730
 .
 36770
 0.09
chr13_98794878_98795058 0.56 FARP1
 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
 152
 0.96
chr14_93672993_93673194 0.55 C14orf142
 chromosome 14 open reading frame 142
 281
 0.5
chr5_96883161_96883631 0.55 CTD-2215E18.2
345812
 0.01
chr16_88865376_88865527 0.55 CDT1
 chromatin licensing and DNA replication factor 1
 4170
 0.11
chr11_113847463_113847737 0.55 HTR3A
 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
 622
 0.76
chr22_34317337_34317549 0.55 LL22NC03-32F9.1
967
 0.44
chr22_21323149_21323300 0.54 AIFM3
 apoptosis-inducing factor, mitochondrion-associated, 3
 1134
 0.29
chr9_102585152_102585422 0.54 NR4A3
 nuclear receptor subfamily 4, group A, member 3
 1150
 0.6
chr7_40638841_40639130 0.54 AC004988.1
52458
 0.18
chr19_35939401_35939552 0.54 FFAR2
 free fatty acid receptor 2
 273
 0.86
chr2_242866226_242866494 0.54 AC131097.3
9627
 0.16
chr10_52382609_52382760 0.54 SGMS1
 sphingomyelin synthase 1
 1059
 0.45
chr4_57775541_57775692 0.54 REST
 RE1-silencing transcription factor
 1541
 0.4
chr7_26142036_26142187 0.53 ENSG00000266430
 .
 42152
 0.14
chr9_92035198_92035541 0.53 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 1621
 0.47
chr1_117281810_117282316 0.53 CD2
 CD2 molecule
 14944
 0.19
chr13_97875305_97875640 0.52 MBNL2
 muscleblind-like splicing regulator 2
 863
 0.74
chr6_159084975_159085126 0.52 SYTL3
 synaptotagmin-like 3
 855
 0.61
chr8_11142479_11142630 0.52 MTMR9
 myotubularin related protein 9
 49
 0.97
chr21_46340456_46340607 0.52 ITGB2
 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
 239
 0.66
chr21_43643624_43643976 0.52 ENSG00000223262
 .
 2517
 0.25
chr1_24117965_24118246 0.51 LYPLA2
 lysophospholipase II
 377
 0.76
chr16_405193_405344 0.51 AXIN1
 axin 1
 2609
 0.16
chr14_100689570_100689752 0.51 YY1
 YY1 transcription factor
 14974
 0.11
chr22_21195761_21195912 0.51 PI4KA
 phosphatidylinositol 4-kinase, catalytic, alpha
 17234
 0.13
chr5_175560441_175560592 0.51 FAM153B
 family with sequence similarity 153, member B
 48607
 0.12
chr19_6481975_6482355 0.51 DENND1C
 DENN/MADD domain containing 1C
 346
 0.75
chr16_25041687_25041875 0.50 ARHGAP17
 Rho GTPase activating protein 17
 14794
 0.24
chr4_54231501_54231662 0.50 SCFD2
 sec1 family domain containing 2
 647
 0.76
chr3_43222048_43222358 0.50 ENSG00000222331
 .
 30160
 0.19
chr18_43923710_43923861 0.49 RNF165
 ring finger protein 165
 9598
 0.29
chr17_47819458_47819764 0.49 FAM117A
 family with sequence similarity 117, member A
 17722
 0.14
chr2_8680555_8680795 0.49 AC011747.7
135221
 0.05
chr1_27940841_27941116 0.49 FGR
 feline Gardner-Rasheed sarcoma viral oncogene homolog
 9595
 0.14
chr5_102138051_102138478 0.49 PAM
 peptidylglycine alpha-amidating monooxygenase
 47217
 0.2
chr11_128576042_128576248 0.49 SENCR
 smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA
 10227
 0.18
chr9_139000327_139000606 0.48 C9orf69
 chromosome 9 open reading frame 69
 9654
 0.19
chr4_165878343_165878497 0.48 FAM218A
 family with sequence similarity 218, member A
 320
 0.91
chr1_154381143_154381298 0.48 RP11-350G8.5
2180
 0.21
chr7_142012902_142013111 0.48 PRSS3P3
 protease, serine, 3 pseudogene 3
 23397
 0.2
chr1_26688110_26688261 0.47 AIM1L
 absent in melanoma 1-like
 7564
 0.12
chr12_95186500_95186671 0.47 ENSG00000208038
 .
 41589
 0.19
chr7_37960937_37961095 0.47 EPDR1
 ependymin related 1
 94
 0.97
chr19_50031302_50031619 0.47 RCN3
 reticulocalbin 3, EF-hand calcium binding domain
 87
 0.9
chr19_51729216_51729410 0.47 CD33
 CD33 molecule
 959
 0.37
chr1_43398456_43398646 0.47 SLC2A1
 solute carrier family 2 (facilitated glucose transporter), member 1
 1755
 0.36
chr17_29821867_29822018 0.47 RAB11FIP4
 RAB11 family interacting protein 4 (class II)
 6816
 0.14
chr7_157112627_157112778 0.47 ENSG00000266453
 .
 14215
 0.22
chr17_75868336_75868487 0.47 FLJ45079
10248
 0.24
chr12_56531942_56532093 0.46 RP11-603J24.5
8614
 0.06
chr1_113589245_113589478 0.46 LRIG2
 leucine-rich repeats and immunoglobulin-like domains 2
 26470
 0.22
chr1_169664801_169665268 0.46 SELL
 selectin L
 15805
 0.19
chr1_206943641_206943792 0.46 IL10
 interleukin 10
 2123
 0.27
chr16_57578366_57578542 0.45 GPR114
 G protein-coupled receptor 114
 1853
 0.28
chr8_245965_246116 0.45 RP5-855D21.2
58995
 0.1
chr13_99878346_99878528 0.45 ENSG00000201793
 .
 20475
 0.16
chr9_26956632_26956885 0.45 IFT74
 intraflagellar transport 74 homolog (Chlamydomonas)
 281
 0.65
chr1_206968223_206968416 0.44 IL19
 interleukin 19
 3896
 0.2
chr16_50699390_50699541 0.44 RP11-401P9.5
657
 0.62
chr1_65627081_65627232 0.44 AK4
 adenylate kinase 4
 13270
 0.24
chr3_39424652_39424838 0.44 SLC25A38
 solute carrier family 25, member 38
 94
 0.96
chr17_76254387_76254694 0.44 TMEM235
 transmembrane protein 235
 26418
 0.12
chr17_62316484_62316635 0.43 TEX2
 testis expressed 2
 8443
 0.22
chr19_51971617_51971885 0.43 CEACAM18
 carcinoembryonic antigen-related cell adhesion molecule 18
 8087
 0.1
chr5_76926544_76926695 0.43 OTP
 orthopedia homeobox
 8894
 0.23
chr8_145051772_145051990 0.43 PLEC
 plectin
 979
 0.36
chrX_39170131_39170563 0.43 ENSG00000207122
 .
 229809
 0.02
chr13_100039643_100039794 0.43 ENSG00000207719
 .
 31333
 0.17
chr17_3818534_3818741 0.43 P2RX1
 purinergic receptor P2X, ligand-gated ion channel, 1
 1157
 0.44
chr16_67837738_67838160 0.43 RANBP10
 RAN binding protein 10
 2511
 0.15
chr17_55362857_55363379 0.43 MSI2
 musashi RNA-binding protein 2
 87
 0.98
chr1_203597474_203597694 0.43 ATP2B4
 ATPase, Ca++ transporting, plasma membrane 4
 1656
 0.46
chr1_154457751_154458027 0.42 SHE
 Src homology 2 domain containing E
 631
 0.6
chr16_374247_374531 0.42 AXIN1
 axin 1
 28060
 0.08
chr3_13236189_13236340 0.42 IQSEC1
 IQ motif and Sec7 domain 1
 121647
 0.06
chr15_99094347_99094498 0.42 FAM169B
 family with sequence similarity 169, member B
 36811
 0.2
chr16_75605342_75605493 0.42 GABARAPL2
 GABA(A) receptor-associated protein-like 2
 4921
 0.14
chr1_160987971_160988369 0.42 F11R
 F11 receptor
 2716
 0.15
chr1_151679471_151679622 0.41 CELF3
 CUGBP, Elav-like family member 3
 840
 0.36
chr12_4082012_4082345 0.41 RP11-664D1.1
67792
 0.12
chr2_106474919_106475126 0.41 AC009505.2
1389
 0.5
chr1_200983739_200983994 0.41 KIF21B
 kinesin family member 21B
 8670
 0.19
chr1_796831_796982 0.41 AL645608.2
21137
 0.12
chr11_111412239_111412489 0.41 LAYN
 layilin
 87
 0.95
chr2_234159952_234160103 0.41 ATG16L1
 autophagy related 16-like 1 (S. cerevisiae)
 190
 0.93
chr4_6964522_6964707 0.40 TBC1D14
 TBC1 domain family, member 14
 8667
 0.14
chr8_24151353_24151528 0.40 ADAM28
 ADAM metallopeptidase domain 28
 113
 0.98
chr17_3863678_3863829 0.40 ATP2A3
 ATPase, Ca++ transporting, ubiquitous
 3832
 0.22
chr1_155009109_155009453 0.40 DCST1
 DC-STAMP domain containing 1
 2835
 0.1
chr9_140045822_140045973 0.40 GRIN1
 glutamate receptor, ionotropic, N-methyl D-aspartate 1
 11964
 0.06
chr11_48102714_48102946 0.40 ENSG00000263693
 .
 15504
 0.22
chr2_101949101_101949252 0.40 ENSG00000264857
 .
 23264
 0.16
chr11_117822226_117822384 0.40 TMPRSS13
 transmembrane protease, serine 13
 22131
 0.15
chr4_109351683_109351834 0.39 ENSG00000266046
 .
 146538
 0.04
chr13_34318080_34318631 0.39 RFC3
 replication factor C (activator 1) 3, 38kDa
 73831
 0.12
chr9_117690184_117690335 0.39 TNFSF8
 tumor necrosis factor (ligand) superfamily, member 8
 2438
 0.4
chr11_58347260_58347411 0.38 ZFP91
 ZFP91 zinc finger protein
 751
 0.54
chr5_95194711_95194982 0.38 ENSG00000250362
 .
 2644
 0.2
chr3_71703355_71703506 0.38 FOXP1
 forkhead box P1
 70290
 0.09
chr11_74662937_74663088 0.38 SPCS2
 signal peptidase complex subunit 2 homolog (S. cerevisiae)
 2443
 0.19
chr18_47824525_47824817 0.38 CXXC1
 CXXC finger protein 1
 9997
 0.15
chr11_64126806_64126957 0.37 RPS6KA4
 ribosomal protein S6 kinase, 90kDa, polypeptide 4
 125
 0.92
chr9_104211779_104211948 0.37 ALDOB
 aldolase B, fructose-bisphosphate
 13758
 0.14
chr7_129908667_129908818 0.37 CPA2
 carboxypeptidase A2 (pancreatic)
 2075
 0.25
chr17_73566405_73566556 0.37 MYO15B
 myosin XVB pseudogene
 20378
 0.1
chr9_131124320_131124475 0.37 URM1
 ubiquitin related modifier 1
 9201
 0.1
chrX_78420820_78421003 0.37 GPR174
 G protein-coupled receptor 174
 5558
 0.35
chr8_58907122_58907322 0.37 FAM110B
 family with sequence similarity 110, member B
 109
 0.98
chr2_219993360_219993640 0.37 ENSG00000240317
 .
 26344
 0.08
chr1_182759043_182759194 0.37 NPL
 N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
 207
 0.95
chr17_46102923_46103182 0.37 COPZ2
 coatomer protein complex, subunit zeta 2
 8186
 0.09
chr6_11380234_11380472 0.37 NEDD9
 neural precursor cell expressed, developmentally down-regulated 9
 2179
 0.43
chr17_79005380_79005531 0.37 BAIAP2
 BAI1-associated protein 2
 3495
 0.16
chr19_55136229_55136380 0.37 ENSG00000264799
 .
 4610
 0.12
chr11_4111133_4111394 0.37 RRM1
 ribonucleotide reductase M1
 4776
 0.22
chr1_229797401_229797552 0.37 URB2
 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
 10882
 0.21
chr10_99894914_99895070 0.37 R3HCC1L
 R3H domain and coiled-coil containing 1-like
 564
 0.83
chr9_95792049_95792266 0.37 FGD3
 FYVE, RhoGEF and PH domain containing 3
 14815
 0.18
chr19_17862547_17862728 0.36 FCHO1
 FCH domain only 1
 292
 0.86
chr5_54523316_54523467 0.36 MCIDAS
 multiciliate differentiation and DNA synthesis associated cell cycle protein
 248
 0.88
chr2_102914112_102914534 0.36 IL1RL1
 interleukin 1 receptor-like 1
 13639
 0.19
chr4_53525877_53526028 0.36 USP46
 ubiquitin specific peptidase 46
 450
 0.84
chr7_37734454_37734605 0.36 GPR141
 G protein-coupled receptor 141
 11054
 0.23
chr5_112054668_112054870 0.36 APC
 adenomatous polyposis coli
 11550
 0.24
chr8_99954932_99955099 0.36 STK3
 serine/threonine kinase 3
 40
 0.97
chr5_143549883_143550034 0.36 YIPF5
 Yip1 domain family, member 5
 236
 0.7
chr16_69166899_69167129 0.36 CIRH1A
 cirrhosis, autosomal recessive 1A (cirhin)
 227
 0.74
chr9_139515902_139516065 0.36 ENSG00000252440
 .
 19016
 0.09
chr20_1111581_1111955 0.35 PSMF1
 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
 4053
 0.25
chr8_10588360_10588511 0.35 SOX7
 SRY (sex determining region Y)-box 7
 413
 0.74
chr5_55626039_55626389 0.35 ENSG00000210678
 .
 32698
 0.18
chr21_39844669_39844820 0.35 ERG
 v-ets avian erythroblastosis virus E26 oncogene homolog
 25601
 0.26
chr1_19991027_19991230 0.35 HTR6
 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
 652
 0.69
chr2_8450496_8450864 0.35 AC011747.7
365216
 0.01
chr12_105074262_105074425 0.35 ENSG00000264295
 .
 88932
 0.08
chr12_93322034_93322185 0.35 EEA1
 early endosome antigen 1
 998
 0.61
chr1_28451935_28452285 0.35 ENSG00000253005
 .
 17242
 0.12
chr5_159826406_159826584 0.34 C5orf54
 chromosome 5 open reading frame 54
 548
 0.71
chrX_9926593_9926744 0.34 AC002365.1
 Homo sapiens uncharacterized LOC100288814 (LOC100288814), mRNA.
 8724
 0.21
chr3_50312444_50312595 0.34 LSMEM2
 leucine-rich single-pass membrane protein 2
 3939
 0.09
chr14_98637898_98638078 0.34 ENSG00000222066
 .
 160099
 0.04
chr6_16634011_16634287 0.34 RP1-151F17.1
127220
 0.06
chr10_114501840_114502050 0.34 RP11-25C19.3
64367
 0.12
chr5_55904489_55904655 0.34 AC022431.2
 Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.
 2513
 0.36
chr1_154968975_154969126 0.34 LENEP
 lens epithelial protein
 2986
 0.1
chr2_198169813_198170140 0.34 ANKRD44-IT1
 ANKRD44 intronic transcript 1 (non-protein coding)
 2733
 0.23
chr17_72588151_72588338 0.34 CD300LD
 CD300 molecule-like family member d
 178
 0.91
chr2_71692941_71693092 0.34 DYSF
 dysferlin
 816
 0.72
chr3_196669893_196670052 0.33 NCBP2
 nuclear cap binding protein subunit 2, 20kDa
 504
 0.69
chr2_149309885_149310036 0.33 MBD5
 methyl-CpG binding domain protein 5
 83666
 0.1
chr2_2690206_2690393 0.33 ENSG00000263570
 .
 330803
 0.01
chr3_30653249_30653701 0.33 TGFBR2
 transforming growth factor, beta receptor II (70/80kDa)
 5382
 0.33
chr9_97402176_97402371 0.33 FBP1
 fructose-1,6-bisphosphatase 1
 146
 0.97
chr6_53155154_53155631 0.33 ENSG00000264056
 .
 13601
 0.2
chr12_105043947_105044098 0.33 ENSG00000264295
 .
 58611
 0.13
chr5_131778755_131778906 0.33 AC116366.5
16424
 0.12
chr6_91182223_91182574 0.33 ENSG00000252676
 .
 25907
 0.24

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB49

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.1 0.3 GO:0036336 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.1 0.3 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.1 0.3 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 0.2 GO:0007132 meiotic metaphase I(GO:0007132)
0.1 0.3 GO:0014805 smooth muscle adaptation(GO:0014805)
0.1 0.2 GO:0097576 vacuole fusion(GO:0097576)
0.1 0.2 GO:0001865 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.1 0.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 0.3 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.1 0.4 GO:0045217 cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.1 0.2 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.1 0.2 GO:0010842 retina layer formation(GO:0010842)
0.1 0.4 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.1 0.2 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.1 0.2 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.1 0.2 GO:0008215 spermine metabolic process(GO:0008215)
0.1 0.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 0.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1 0.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.1 0.2 GO:0032100 positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.1 0.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0002524 hypersensitivity(GO:0002524) regulation of hypersensitivity(GO:0002883)
0.0 0.1 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.0 0.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.2 GO:0001878 response to yeast(GO:0001878)
0.0 0.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.2 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.1 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:0001820 serotonin secretion(GO:0001820)
0.0 0.1 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.1 GO:0060596 mammary placode formation(GO:0060596)
0.0 0.1 GO:0034244 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.1 GO:0001821 histamine secretion(GO:0001821)
0.0 0.2 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.0 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.1 GO:0006168 adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0 0.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.8 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.2 GO:0002857 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.1 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.0 0.7 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.8 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 0.1 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.1 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 0.0 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 0.1 GO:0046101 hypoxanthine biosynthetic process(GO:0046101)
0.0 0.0 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.4 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 0.4 GO:0001706 endoderm formation(GO:0001706)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.0 GO:0043383 negative T cell selection(GO:0043383)
0.0 0.1 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.2 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.1 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.1 GO:0048563 post-embryonic organ morphogenesis(GO:0048563)
0.0 0.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.0 GO:1900120 regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0 0.1 GO:0090322 regulation of superoxide metabolic process(GO:0090322)
0.0 0.1 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.0 GO:0032661 interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661)
0.0 0.1 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.2 GO:0051882 mitochondrial depolarization(GO:0051882)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.2 GO:0003407 neural retina development(GO:0003407)
0.0 0.0 GO:0003254 regulation of membrane depolarization(GO:0003254)
0.0 0.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:2000794 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0 0.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.3 GO:0000045 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.1 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.1 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.0 GO:0001973 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.1 GO:0007090 obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0 0.3 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.0 0.1 GO:0003179 heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.1 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.0 GO:0034135 regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.0 0.1 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.3 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.3 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.0 0.0 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.0 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.3 GO:0030325 adrenal gland development(GO:0030325)
0.0 0.1 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.1 GO:0060317 cardiac epithelial to mesenchymal transition(GO:0060317)
0.0 0.2 GO:0042226 interleukin-6 biosynthetic process(GO:0042226)
0.0 0.2 GO:0042772 DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.0 0.0 GO:0003078 obsolete regulation of natriuresis(GO:0003078)
0.0 0.2 GO:0045061 thymic T cell selection(GO:0045061)
0.0 0.0 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.2 GO:0007141 male meiosis I(GO:0007141)
0.0 0.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.0 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.1 GO:2001257 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314) regulation of calcium ion transmembrane transporter activity(GO:1901019) regulation of cation channel activity(GO:2001257)
0.0 0.2 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.0 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.2 GO:0045576 mast cell activation(GO:0045576)
0.0 0.1 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.1 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.0 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.1 GO:0008653 lipopolysaccharide metabolic process(GO:0008653)
0.0 0.1 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.1 GO:0052646 alditol phosphate metabolic process(GO:0052646)
0.0 0.0 GO:0010288 response to lead ion(GO:0010288)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.0 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:1904031 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 0.0 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0 0.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.0 GO:0035054 embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934)
0.0 0.0 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.0 GO:0033622 integrin activation(GO:0033622)
0.0 0.0 GO:0043374 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.0 GO:0003057 regulation of the force of heart contraction by chemical signal(GO:0003057)
0.0 0.0 GO:0051176 positive regulation of sulfur metabolic process(GO:0051176)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.0 GO:0006560 proline metabolic process(GO:0006560)
0.0 0.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.0 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.0 GO:0043552 regulation of phosphatidylinositol 3-kinase activity(GO:0043551) positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.0 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 0.3 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.1 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.0 GO:0010586 miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0 0.1 GO:0000085 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.0 GO:0048541 Peyer's patch development(GO:0048541)
0.0 0.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0016572 histone phosphorylation(GO:0016572)
0.0 0.0 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0 0.0 GO:0071503 response to heparin(GO:0071503)
0.0 0.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.0 GO:0050685 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.1 GO:0043628 ncRNA 3'-end processing(GO:0043628)
0.0 0.0 GO:0090085 regulation of protein deubiquitination(GO:0090085)
0.0 0.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.0 GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0 0.0 GO:0006922 obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0 0.0 GO:0070254 mucus secretion(GO:0070254)
0.0 0.1 GO:0006983 ER overload response(GO:0006983)
0.0 0.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.0 GO:0010954 positive regulation of protein processing(GO:0010954) positive regulation of protein maturation(GO:1903319)
0.0 0.0 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.0 GO:0043441 acetoacetic acid biosynthetic process(GO:0043441)
0.0 0.0 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.3 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.0 GO:0045056 transcytosis(GO:0045056)
0.0 0.0 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.0 0.1 GO:0051294 establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0 0.1 GO:0051593 response to folic acid(GO:0051593)
0.0 0.0 GO:0045759 negative regulation of action potential(GO:0045759)
0.0 0.0 GO:0097531 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.0 GO:0060263 regulation of respiratory burst(GO:0060263)
0.0 0.0 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.2 GO:1990266 neutrophil chemotaxis(GO:0030593) neutrophil migration(GO:1990266)
0.0 0.0 GO:0021984 adenohypophysis development(GO:0021984)
0.0 0.1 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:0071445 obsolete cellular response to protein stimulus(GO:0071445)
0.0 0.0 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.7 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.1 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.0 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0010165 response to X-ray(GO:0010165)
0.0 0.0 GO:0048867 stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0 0.2 GO:0019674 NAD metabolic process(GO:0019674)
0.0 0.0 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.0 0.0 GO:0046639 negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0 0.0 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0044462 external encapsulating structure part(GO:0044462)
0.1 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.3 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.3 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.5 GO:0005844 polysome(GO:0005844)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.1 GO:0032009 early phagosome(GO:0032009)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.0 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0043209 myelin sheath(GO:0043209)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.0 GO:0070188 obsolete Stn1-Ten1 complex(GO:0070188)
0.0 0.2 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.2 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.1 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.0 GO:0071547 piP-body(GO:0071547)
0.0 0.0 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.0 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.5 GO:0005903 brush border(GO:0005903)
0.0 0.3 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.3 GO:0002060 purine nucleobase binding(GO:0002060)
0.1 0.6 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.2 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.1 0.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.4 GO:0004969 histamine receptor activity(GO:0004969)
0.1 0.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.2 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.3 GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.1 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.4 GO:0051378 serotonin binding(GO:0051378)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.2 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.2 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.2 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.6 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 0.2 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.1 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.2 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.1 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.0 GO:0004992 platelet activating factor receptor activity(GO:0004992)
0.0 0.1 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.4 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.2 GO:0071617 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0 0.1 GO:0004370 glycerol kinase activity(GO:0004370)
0.0 0.1 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0045159 myosin II binding(GO:0045159)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.3 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.0 0.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.2 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.7 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.4 GO:0051117 ATPase binding(GO:0051117)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.3 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.1 GO:0016595 glutamate binding(GO:0016595)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0051635 obsolete bacterial cell surface binding(GO:0051635)
0.0 0.2 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.0 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.4 GO:0016502 G-protein coupled nucleotide receptor activity(GO:0001608) purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity(GO:0016847)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.0 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.0 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.0 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.1 GO:0070402 NADPH binding(GO:0070402)
0.0 0.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.0 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.3 GO:0019210 kinase inhibitor activity(GO:0019210)
0.0 0.1 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.1 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.0 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.0 GO:0035197 siRNA binding(GO:0035197)
0.0 0.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.0 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.0 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.2 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.0 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.0 GO:0043734 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.0 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.2 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.0 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.0 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.0 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.0 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.8 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.0 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.0 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.2 PID IGF1 PATHWAY IGF1 pathway
0.0 0.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.1 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.1 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.3 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.1 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.3 PID HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 1.0 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.2 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.0 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.1 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.5 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.2 REACTOME IL 3 5 AND GM CSF SIGNALING Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.0 0.2 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.2 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.1 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.0 REACTOME RNA POL I TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.0 0.2 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events
0.0 0.2 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.1 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.1 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex