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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZBTB49

Z-value: 1.87

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Transcription factors associated with ZBTB49

Gene Symbol	Gene ID	Gene Info
ZBTB49 Ensembl NCBI GeneCards UniProt	ENSG00000168826.11	ZBTB49

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZBTB49	chr4_4311282_4311433	7003	0.189887	-0.76	1.7e-02	Click!
ZBTB49	chr4_4310564_4310715	6285	0.193270	-0.68	4.4e-02	Click!
ZBTB49	chr4_4310239_4310390	5960	0.195151	-0.66	5.4e-02	Click!
ZBTB49	chr4_4293176_4293389	1286	0.341867	0.56	1.2e-01	Click!
ZBTB49	chr4_4292418_4292569	497	0.515006	0.54	1.4e-01	Click!

Activity of the ZBTB49 motif across conditions

Conditions sorted by the z-value of the ZBTB49 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr14_35591551_35591702	0.91	PPP2R3C	protein phosphatase 2, regulatory subunit B'', gamma	53	0.58
chr5_65440945_65441096	0.89	SREK1	splicing regulatory glutamine/lysine-rich protein 1	357	0.52
chr1_197879321_197879472	0.77	LHX9	LIM homeobox 9	2225	0.36
chr11_122714029_122714331	0.76	CRTAM	cytotoxic and regulatory T cell molecule	4972	0.24
chr3_194023502_194023858	0.76	CPN2	carboxypeptidase N, polypeptide 2	48367	0.13
chr1_9764053_9764209	0.74	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	6125	0.18
chr14_89913899_89914115	0.72	FOXN3-AS1	FOXN3 antisense RNA 1	30309	0.15
chr1_157819053_157819204	0.72	CD5L	CD5 molecule-like	7540	0.21
chr12_47756185_47756391	0.71	ENSG00000264906	.	1764	0.4
chr5_176787986_176788182	0.70	RGS14	regulator of G-protein signaling 14	3246	0.13
chr9_134377992_134378202	0.70	POMT1	protein-O-mannosyltransferase 1	192	0.92
chr15_101061308_101061579	0.69	CERS3	ceramide synthase 3	23033	0.14
chr5_66118075_66118363	0.68	MAST4	microtubule associated serine/threonine kinase family member 4	6383	0.33
chr2_220112096_220112414	0.66	STK16	serine/threonine kinase 16	1637	0.15
chr12_11699871_11700022	0.66	ENSG00000251747	.	533	0.78
chr17_3818792_3818943	0.65	P2RX1	purinergic receptor P2X, ligand-gated ion channel, 1	927	0.52
chr19_8570015_8570216	0.65	PRAM1	PML-RARA regulated adaptor molecule 1	2119	0.2
chr6_121758459_121758727	0.65	GJA1	gap junction protein, alpha 1, 43kDa	1755	0.35
chr7_3108313_3108464	0.65	CARD11	caspase recruitment domain family, member 11	24809	0.21
chr1_26869946_26870282	0.64	RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	511	0.72
chr5_169698686_169698837	0.64	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	4430	0.26
chr19_14464423_14464642	0.63	CD97	CD97 molecule	27436	0.13
chr3_20084242_20084393	0.63	KAT2B	K(lysine) acetyltransferase 2B	2802	0.27
chr11_46371500_46371856	0.62	DGKZ	diacylglycerol kinase, zeta	2540	0.22
chr1_182558263_182558414	0.62	RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	53	0.98
chr1_154988213_154988563	0.61	ZBTB7B	zinc finger and BTB domain containing 7B	1464	0.18
chr4_40207735_40207928	0.60	RHOH	ras homolog family member H	5867	0.23
chr4_8173290_8173441	0.60	SH3TC1	SH3 domain and tetratricopeptide repeats 1	10437	0.21
chr22_50752388_50752886	0.60	XX-C283C717.1		423	0.69
chrX_9542077_9542228	0.60	TBL1X	transducin (beta)-like 1X-linked	39169	0.22
chr17_74028313_74028464	0.59	EVPL	envoplakin	4855	0.12
chr12_105085856_105086193	0.59	ENSG00000264295	.	100613	0.07
chr3_31274169_31274365	0.59	ENSG00000222983	.	4060	0.33
chr16_50309977_50310263	0.59	ADCY7	adenylate cyclase 7	2056	0.34
chr11_47237830_47237981	0.59	DDB2	damage-specific DNA binding protein 2, 48kDa	1412	0.25
chr12_65176538_65176711	0.59	TBC1D30	TBC1 domain family, member 30	1650	0.32
chr7_26373644_26373838	0.59	SNX10	sorting nexin 10	19936	0.21
chr16_2918250_2918510	0.58	PRSS22	protease, serine, 22	10209	0.08
chr17_7308499_7308674	0.58	NLGN2	neuroligin 2	393	0.52
chr20_61604608_61604759	0.58	SLC17A9	solute carrier family 17 (vesicular nucleotide transporter), member 9	20285	0.14
chr2_233186649_233186800	0.57	DIS3L2	DIS3 mitotic control homolog (S. cerevisiae)-like 2	11929	0.18
chr2_198126272_198126712	0.57	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	40751	0.13
chr3_183208611_183208762	0.57	ENSG00000251730	.	36770	0.09
chr13_98794878_98795058	0.56	FARP1	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)	152	0.96
chr14_93672993_93673194	0.55	C14orf142	chromosome 14 open reading frame 142	281	0.5
chr5_96883161_96883631	0.55	CTD-2215E18.2		345812	0.01
chr16_88865376_88865527	0.55	CDT1	chromatin licensing and DNA replication factor 1	4170	0.11
chr11_113847463_113847737	0.55	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	622	0.76
chr22_34317337_34317549	0.55	LL22NC03-32F9.1		967	0.44
chr22_21323149_21323300	0.54	AIFM3	apoptosis-inducing factor, mitochondrion-associated, 3	1134	0.29
chr9_102585152_102585422	0.54	NR4A3	nuclear receptor subfamily 4, group A, member 3	1150	0.6
chr7_40638841_40639130	0.54	AC004988.1		52458	0.18
chr19_35939401_35939552	0.54	FFAR2	free fatty acid receptor 2	273	0.86
chr2_242866226_242866494	0.54	AC131097.3		9627	0.16
chr10_52382609_52382760	0.54	SGMS1	sphingomyelin synthase 1	1059	0.45
chr4_57775541_57775692	0.54	REST	RE1-silencing transcription factor	1541	0.4
chr7_26142036_26142187	0.53	ENSG00000266430	.	42152	0.14
chr9_92035198_92035541	0.53	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	1621	0.47
chr1_117281810_117282316	0.53	CD2	CD2 molecule	14944	0.19
chr13_97875305_97875640	0.52	MBNL2	muscleblind-like splicing regulator 2	863	0.74
chr6_159084975_159085126	0.52	SYTL3	synaptotagmin-like 3	855	0.61
chr8_11142479_11142630	0.52	MTMR9	myotubularin related protein 9	49	0.97
chr21_46340456_46340607	0.52	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	239	0.66
chr21_43643624_43643976	0.52	ENSG00000223262	.	2517	0.25
chr1_24117965_24118246	0.51	LYPLA2	lysophospholipase II	377	0.76
chr16_405193_405344	0.51	AXIN1	axin 1	2609	0.16
chr14_100689570_100689752	0.51	YY1	YY1 transcription factor	14974	0.11
chr22_21195761_21195912	0.51	PI4KA	phosphatidylinositol 4-kinase, catalytic, alpha	17234	0.13
chr5_175560441_175560592	0.51	FAM153B	family with sequence similarity 153, member B	48607	0.12
chr19_6481975_6482355	0.51	DENND1C	DENN/MADD domain containing 1C	346	0.75
chr16_25041687_25041875	0.50	ARHGAP17	Rho GTPase activating protein 17	14794	0.24
chr4_54231501_54231662	0.50	SCFD2	sec1 family domain containing 2	647	0.76
chr3_43222048_43222358	0.50	ENSG00000222331	.	30160	0.19
chr18_43923710_43923861	0.49	RNF165	ring finger protein 165	9598	0.29
chr17_47819458_47819764	0.49	FAM117A	family with sequence similarity 117, member A	17722	0.14
chr2_8680555_8680795	0.49	AC011747.7		135221	0.05
chr1_27940841_27941116	0.49	FGR	feline Gardner-Rasheed sarcoma viral oncogene homolog	9595	0.14
chr5_102138051_102138478	0.49	PAM	peptidylglycine alpha-amidating monooxygenase	47217	0.2
chr11_128576042_128576248	0.49	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	10227	0.18
chr9_139000327_139000606	0.48	C9orf69	chromosome 9 open reading frame 69	9654	0.19
chr4_165878343_165878497	0.48	FAM218A	family with sequence similarity 218, member A	320	0.91
chr1_154381143_154381298	0.48	RP11-350G8.5		2180	0.21
chr7_142012902_142013111	0.48	PRSS3P3	protease, serine, 3 pseudogene 3	23397	0.2
chr1_26688110_26688261	0.47	AIM1L	absent in melanoma 1-like	7564	0.12
chr12_95186500_95186671	0.47	ENSG00000208038	.	41589	0.19
chr7_37960937_37961095	0.47	EPDR1	ependymin related 1	94	0.97
chr19_50031302_50031619	0.47	RCN3	reticulocalbin 3, EF-hand calcium binding domain	87	0.9
chr19_51729216_51729410	0.47	CD33	CD33 molecule	959	0.37
chr1_43398456_43398646	0.47	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	1755	0.36
chr17_29821867_29822018	0.47	RAB11FIP4	RAB11 family interacting protein 4 (class II)	6816	0.14
chr7_157112627_157112778	0.47	ENSG00000266453	.	14215	0.22
chr17_75868336_75868487	0.47	FLJ45079		10248	0.24
chr12_56531942_56532093	0.46	RP11-603J24.5		8614	0.06
chr1_113589245_113589478	0.46	LRIG2	leucine-rich repeats and immunoglobulin-like domains 2	26470	0.22
chr1_169664801_169665268	0.46	SELL	selectin L	15805	0.19
chr1_206943641_206943792	0.46	IL10	interleukin 10	2123	0.27
chr16_57578366_57578542	0.45	GPR114	G protein-coupled receptor 114	1853	0.28
chr8_245965_246116	0.45	RP5-855D21.2		58995	0.1
chr13_99878346_99878528	0.45	ENSG00000201793	.	20475	0.16
chr9_26956632_26956885	0.45	IFT74	intraflagellar transport 74 homolog (Chlamydomonas)	281	0.65
chr1_206968223_206968416	0.44	IL19	interleukin 19	3896	0.2
chr16_50699390_50699541	0.44	RP11-401P9.5		657	0.62
chr1_65627081_65627232	0.44	AK4	adenylate kinase 4	13270	0.24
chr3_39424652_39424838	0.44	SLC25A38	solute carrier family 25, member 38	94	0.96
chr17_76254387_76254694	0.44	TMEM235	transmembrane protein 235	26418	0.12
chr17_62316484_62316635	0.43	TEX2	testis expressed 2	8443	0.22
chr19_51971617_51971885	0.43	CEACAM18	carcinoembryonic antigen-related cell adhesion molecule 18	8087	0.1
chr5_76926544_76926695	0.43	OTP	orthopedia homeobox	8894	0.23
chr8_145051772_145051990	0.43	PLEC	plectin	979	0.36
chrX_39170131_39170563	0.43	ENSG00000207122	.	229809	0.02
chr13_100039643_100039794	0.43	ENSG00000207719	.	31333	0.17
chr17_3818534_3818741	0.43	P2RX1	purinergic receptor P2X, ligand-gated ion channel, 1	1157	0.44
chr16_67837738_67838160	0.43	RANBP10	RAN binding protein 10	2511	0.15
chr17_55362857_55363379	0.43	MSI2	musashi RNA-binding protein 2	87	0.98
chr1_203597474_203597694	0.43	ATP2B4	ATPase, Ca++ transporting, plasma membrane 4	1656	0.46
chr1_154457751_154458027	0.42	SHE	Src homology 2 domain containing E	631	0.6
chr16_374247_374531	0.42	AXIN1	axin 1	28060	0.08
chr3_13236189_13236340	0.42	IQSEC1	IQ motif and Sec7 domain 1	121647	0.06
chr15_99094347_99094498	0.42	FAM169B	family with sequence similarity 169, member B	36811	0.2
chr16_75605342_75605493	0.42	GABARAPL2	GABA(A) receptor-associated protein-like 2	4921	0.14
chr1_160987971_160988369	0.42	F11R	F11 receptor	2716	0.15
chr1_151679471_151679622	0.41	CELF3	CUGBP, Elav-like family member 3	840	0.36
chr12_4082012_4082345	0.41	RP11-664D1.1		67792	0.12
chr2_106474919_106475126	0.41	AC009505.2		1389	0.5
chr1_200983739_200983994	0.41	KIF21B	kinesin family member 21B	8670	0.19
chr1_796831_796982	0.41	AL645608.2		21137	0.12
chr11_111412239_111412489	0.41	LAYN	layilin	87	0.95
chr2_234159952_234160103	0.41	ATG16L1	autophagy related 16-like 1 (S. cerevisiae)	190	0.93
chr4_6964522_6964707	0.40	TBC1D14	TBC1 domain family, member 14	8667	0.14
chr8_24151353_24151528	0.40	ADAM28	ADAM metallopeptidase domain 28	113	0.98
chr17_3863678_3863829	0.40	ATP2A3	ATPase, Ca++ transporting, ubiquitous	3832	0.22
chr1_155009109_155009453	0.40	DCST1	DC-STAMP domain containing 1	2835	0.1
chr9_140045822_140045973	0.40	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	11964	0.06
chr11_48102714_48102946	0.40	ENSG00000263693	.	15504	0.22
chr2_101949101_101949252	0.40	ENSG00000264857	.	23264	0.16
chr11_117822226_117822384	0.40	TMPRSS13	transmembrane protease, serine 13	22131	0.15
chr4_109351683_109351834	0.39	ENSG00000266046	.	146538	0.04
chr13_34318080_34318631	0.39	RFC3	replication factor C (activator 1) 3, 38kDa	73831	0.12
chr9_117690184_117690335	0.39	TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	2438	0.4
chr11_58347260_58347411	0.38	ZFP91	ZFP91 zinc finger protein	751	0.54
chr5_95194711_95194982	0.38	ENSG00000250362	.	2644	0.2
chr3_71703355_71703506	0.38	FOXP1	forkhead box P1	70290	0.09
chr11_74662937_74663088	0.38	SPCS2	signal peptidase complex subunit 2 homolog (S. cerevisiae)	2443	0.19
chr18_47824525_47824817	0.38	CXXC1	CXXC finger protein 1	9997	0.15
chr11_64126806_64126957	0.37	RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	125	0.92
chr9_104211779_104211948	0.37	ALDOB	aldolase B, fructose-bisphosphate	13758	0.14
chr7_129908667_129908818	0.37	CPA2	carboxypeptidase A2 (pancreatic)	2075	0.25
chr17_73566405_73566556	0.37	MYO15B	myosin XVB pseudogene	20378	0.1
chr9_131124320_131124475	0.37	URM1	ubiquitin related modifier 1	9201	0.1
chrX_78420820_78421003	0.37	GPR174	G protein-coupled receptor 174	5558	0.35
chr8_58907122_58907322	0.37	FAM110B	family with sequence similarity 110, member B	109	0.98
chr2_219993360_219993640	0.37	ENSG00000240317	.	26344	0.08
chr1_182759043_182759194	0.37	NPL	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)	207	0.95
chr17_46102923_46103182	0.37	COPZ2	coatomer protein complex, subunit zeta 2	8186	0.09
chr6_11380234_11380472	0.37	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	2179	0.43
chr17_79005380_79005531	0.37	BAIAP2	BAI1-associated protein 2	3495	0.16
chr19_55136229_55136380	0.37	ENSG00000264799	.	4610	0.12
chr11_4111133_4111394	0.37	RRM1	ribonucleotide reductase M1	4776	0.22
chr1_229797401_229797552	0.37	URB2	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	10882	0.21
chr10_99894914_99895070	0.37	R3HCC1L	R3H domain and coiled-coil containing 1-like	564	0.83
chr9_95792049_95792266	0.37	FGD3	FYVE, RhoGEF and PH domain containing 3	14815	0.18
chr19_17862547_17862728	0.36	FCHO1	FCH domain only 1	292	0.86
chr5_54523316_54523467	0.36	MCIDAS	multiciliate differentiation and DNA synthesis associated cell cycle protein	248	0.88
chr2_102914112_102914534	0.36	IL1RL1	interleukin 1 receptor-like 1	13639	0.19
chr4_53525877_53526028	0.36	USP46	ubiquitin specific peptidase 46	450	0.84
chr7_37734454_37734605	0.36	GPR141	G protein-coupled receptor 141	11054	0.23
chr5_112054668_112054870	0.36	APC	adenomatous polyposis coli	11550	0.24
chr8_99954932_99955099	0.36	STK3	serine/threonine kinase 3	40	0.97
chr5_143549883_143550034	0.36	YIPF5	Yip1 domain family, member 5	236	0.7
chr16_69166899_69167129	0.36	CIRH1A	cirrhosis, autosomal recessive 1A (cirhin)	227	0.74
chr9_139515902_139516065	0.36	ENSG00000252440	.	19016	0.09
chr20_1111581_1111955	0.35	PSMF1	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	4053	0.25
chr8_10588360_10588511	0.35	SOX7	SRY (sex determining region Y)-box 7	413	0.74
chr5_55626039_55626389	0.35	ENSG00000210678	.	32698	0.18
chr21_39844669_39844820	0.35	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	25601	0.26
chr1_19991027_19991230	0.35	HTR6	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	652	0.69
chr2_8450496_8450864	0.35	AC011747.7		365216	0.01
chr12_105074262_105074425	0.35	ENSG00000264295	.	88932	0.08
chr12_93322034_93322185	0.35	EEA1	early endosome antigen 1	998	0.61
chr1_28451935_28452285	0.35	ENSG00000253005	.	17242	0.12
chr5_159826406_159826584	0.34	C5orf54	chromosome 5 open reading frame 54	548	0.71
chrX_9926593_9926744	0.34	AC002365.1	Homo sapiens uncharacterized LOC100288814 (LOC100288814), mRNA.	8724	0.21
chr3_50312444_50312595	0.34	LSMEM2	leucine-rich single-pass membrane protein 2	3939	0.09
chr14_98637898_98638078	0.34	ENSG00000222066	.	160099	0.04
chr6_16634011_16634287	0.34	RP1-151F17.1		127220	0.06
chr10_114501840_114502050	0.34	RP11-25C19.3		64367	0.12
chr5_55904489_55904655	0.34	AC022431.2	Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.	2513	0.36
chr1_154968975_154969126	0.34	LENEP	lens epithelial protein	2986	0.1
chr2_198169813_198170140	0.34	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	2733	0.23
chr17_72588151_72588338	0.34	CD300LD	CD300 molecule-like family member d	178	0.91
chr2_71692941_71693092	0.34	DYSF	dysferlin	816	0.72
chr3_196669893_196670052	0.33	NCBP2	nuclear cap binding protein subunit 2, 20kDa	504	0.69
chr2_149309885_149310036	0.33	MBD5	methyl-CpG binding domain protein 5	83666	0.1
chr2_2690206_2690393	0.33	ENSG00000263570	.	330803	0.01
chr3_30653249_30653701	0.33	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	5382	0.33
chr9_97402176_97402371	0.33	FBP1	fructose-1,6-bisphosphatase 1	146	0.97
chr6_53155154_53155631	0.33	ENSG00000264056	.	13601	0.2
chr12_105043947_105044098	0.33	ENSG00000264295	.	58611	0.13
chr5_131778755_131778906	0.33	AC116366.5		16424	0.12
chr6_91182223_91182574	0.33	ENSG00000252676	.	25907	0.24

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB49

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.1	0.3	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.1	0.3	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.1	0.3	GO:0048752	semicircular canal morphogenesis(GO:0048752)
0.1	0.2	GO:0007132	meiotic metaphase I(GO:0007132)
0.1	0.3	GO:0014805	smooth muscle adaptation(GO:0014805)
0.1	0.2	GO:0097576	vacuole fusion(GO:0097576)
0.1	0.2	GO:0001865	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.1	0.2	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1	0.3	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.1	0.4	GO:0045217	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.1	0.2	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.1	0.2	GO:0010842	retina layer formation(GO:0010842)
0.1	0.4	GO:0006002	fructose 6-phosphate metabolic process(GO:0006002)
0.1	0.2	GO:0015868	purine ribonucleotide transport(GO:0015868)
0.1	0.2	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.1	0.2	GO:0008215	spermine metabolic process(GO:0008215)
0.1	0.2	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.1	0.2	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1	0.2	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.1	0.2	GO:0032100	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.1	0.3	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0002524	hypersensitivity(GO:0002524) regulation of hypersensitivity(GO:0002883)
0.0	0.1	GO:0071421	manganese ion transmembrane transport(GO:0071421)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.2	GO:0001878	response to yeast(GO:0001878)
0.0	0.2	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.2	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0001820	serotonin secretion(GO:0001820)
0.0	0.1	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.1	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.1	GO:0034244	negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.2	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0006168	adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.8	GO:0006493	protein O-linked glycosylation(GO:0006493)
0.0	0.2	GO:0002857	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.1	GO:0070102	interleukin-6-mediated signaling pathway(GO:0070102)
0.0	0.7	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0	0.8	GO:0043484	regulation of RNA splicing(GO:0043484)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.1	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.1	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.0	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.0	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.4	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.4	GO:0001706	endoderm formation(GO:0001706)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0043383	negative T cell selection(GO:0043383)
0.0	0.1	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.2	GO:0046716	muscle cell cellular homeostasis(GO:0046716)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.1	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.1	GO:0048563	post-embryonic organ morphogenesis(GO:0048563)
0.0	0.1	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0	0.1	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.1	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.0	GO:1900120	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.1	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.1	GO:0002098	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.2	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0	0.0	GO:0032661	interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.2	GO:0051882	mitochondrial depolarization(GO:0051882)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.2	GO:0003407	neural retina development(GO:0003407)
0.0	0.0	GO:0003254	regulation of membrane depolarization(GO:0003254)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:2000794	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0	0.1	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.3	GO:0000045	autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0	0.1	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.1	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.0	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.3	GO:0006700	C21-steroid hormone biosynthetic process(GO:0006700)
0.0	0.1	GO:0003179	heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.1	GO:0002052	positive regulation of neuroblast proliferation(GO:0002052)
0.0	0.0	GO:0034135	regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.3	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	0.3	GO:0032228	regulation of synaptic transmission, GABAergic(GO:0032228)
0.0	0.0	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.0	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.3	GO:0030325	adrenal gland development(GO:0030325)
0.0	0.1	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.0	0.1	GO:0060317	cardiac epithelial to mesenchymal transition(GO:0060317)
0.0	0.2	GO:0042226	interleukin-6 biosynthetic process(GO:0042226)
0.0	0.2	GO:0042772	DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.0	0.0	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.2	GO:0045061	thymic T cell selection(GO:0045061)
0.0	0.0	GO:0071699	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.2	GO:0007141	male meiosis I(GO:0007141)
0.0	0.4	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)
0.0	0.0	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.1	GO:2001257	regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314) regulation of calcium ion transmembrane transporter activity(GO:1901019) regulation of cation channel activity(GO:2001257)
0.0	0.2	GO:0032781	positive regulation of ATPase activity(GO:0032781)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.2	GO:0045576	mast cell activation(GO:0045576)
0.0	0.1	GO:0032933	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.1	GO:0048703	embryonic viscerocranium morphogenesis(GO:0048703)
0.0	0.0	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.1	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.1	GO:0052646	alditol phosphate metabolic process(GO:0052646)
0.0	0.0	GO:0010288	response to lead ion(GO:0010288)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:1904031	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.0	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.3	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.0	GO:0035054	embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.1	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.0	GO:0033622	integrin activation(GO:0033622)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:0003057	regulation of the force of heart contraction by chemical signal(GO:0003057)
0.0	0.0	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0006560	proline metabolic process(GO:0006560)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.0	GO:0043552	regulation of phosphatidylinositol 3-kinase activity(GO:0043551) positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0	0.0	GO:0010591	regulation of lamellipodium assembly(GO:0010591)
0.0	0.3	GO:0005980	glycogen catabolic process(GO:0005980)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0008628	hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0	0.1	GO:0006658	phosphatidylserine metabolic process(GO:0006658)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0032148	activation of protein kinase B activity(GO:0032148)
0.0	0.0	GO:0010586	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.1	GO:0000085	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.0	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.0	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.0	GO:0071503	response to heparin(GO:0071503)
0.0	0.0	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.0	GO:0050685	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.1	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.0	GO:0090085	regulation of protein deubiquitination(GO:0090085)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.0	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0	0.0	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.0	GO:0070254	mucus secretion(GO:0070254)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.9	GO:0035023	regulation of Rho protein signal transduction(GO:0035023)
0.0	0.0	GO:0010954	positive regulation of protein processing(GO:0010954) positive regulation of protein maturation(GO:1903319)
0.0	0.0	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.0	GO:0043441	acetoacetic acid biosynthetic process(GO:0043441)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.3	GO:0070830	bicellular tight junction assembly(GO:0070830)
0.0	0.0	GO:0045056	transcytosis(GO:0045056)
0.0	0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.1	GO:0051294	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.1	GO:0051593	response to folic acid(GO:0051593)
0.0	0.0	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.0	GO:0097531	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.0	GO:0060263	regulation of respiratory burst(GO:0060263)
0.0	0.0	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.2	GO:1990266	neutrophil chemotaxis(GO:0030593) neutrophil migration(GO:1990266)
0.0	0.0	GO:0021984	adenohypophysis development(GO:0021984)
0.0	0.1	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.1	GO:0071445	obsolete cellular response to protein stimulus(GO:0071445)
0.0	0.0	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.7	GO:0071357	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0	0.1	GO:0019317	fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0010165	response to X-ray(GO:0010165)
0.0	0.0	GO:0048867	stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0	0.2	GO:0019674	NAD metabolic process(GO:0019674)
0.0	0.0	GO:0045618	positive regulation of keratinocyte differentiation(GO:0045618)
0.0	0.0	GO:0046639	negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0	0.0	GO:0048147	negative regulation of fibroblast proliferation(GO:0048147)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0044462	external encapsulating structure part(GO:0044462)
0.1	0.4	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.1	0.2	GO:0000138	Golgi trans cisterna(GO:0000138)
0.1	0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.3	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.2	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.2	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.1	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.3	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.3	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.5	GO:0005844	polysome(GO:0005844)
0.0	0.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.1	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.1	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.1	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.2	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.2	GO:0043209	myelin sheath(GO:0043209)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.3	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	0.2	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.0	0.1	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.0	GO:0071547	piP-body(GO:0071547)
0.0	0.0	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.0	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.5	GO:0005903	brush border(GO:0005903)
0.0	0.3	GO:0008305	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1	0.3	GO:0002060	purine nucleobase binding(GO:0002060)
0.1	0.6	GO:0004931	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1	0.5	GO:0008266	poly(U) RNA binding(GO:0008266)
0.1	0.2	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.4	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.1	0.4	GO:0004969	histamine receptor activity(GO:0004969)
0.1	0.3	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.1	0.2	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.3	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.3	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.4	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.4	GO:0051378	serotonin binding(GO:0051378)
0.0	0.3	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.4	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.3	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.2	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.6	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.2	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.2	GO:0001595	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.6	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0	0.2	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.1	GO:0070735	protein-glycine ligase activity(GO:0070735)
0.0	0.2	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.3	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.0	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	0.1	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.4	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.0	0.2	GO:0071617	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0004308	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0045159	myosin II binding(GO:0045159)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.2	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.3	GO:0030291	protein serine/threonine kinase inhibitor activity(GO:0030291)
0.0	0.1	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.7	GO:0036459	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.1	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.4	GO:0051117	ATPase binding(GO:0051117)
0.0	0.3	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.3	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0016595	glutamate binding(GO:0016595)
0.0	0.1	GO:0004803	transposase activity(GO:0004803)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.2	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.1	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.0	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.4	GO:0016502	G-protein coupled nucleotide receptor activity(GO:0001608) purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0016847	1-aminocyclopropane-1-carboxylate synthase activity(GO:0016847)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.3	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.1	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.0	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.2	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.3	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.0	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.9	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.1	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0	0.0	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.1	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0070402	NADPH binding(GO:0070402)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.0	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.3	GO:0019210	kinase inhibitor activity(GO:0019210)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.1	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.0	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.0	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.2	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.0	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.0	GO:0043734	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.0	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.2	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.1	GO:0070567	cytidylyltransferase activity(GO:0070567)
0.0	0.2	GO:0015485	cholesterol binding(GO:0015485)
0.0	0.0	GO:0003964	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0	0.1	GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0	0.0	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.3	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	0.0	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
1.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.8	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.9	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.2	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.4	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.5	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.2	PID IGF1 PATHWAY	IGF1 pathway
0.4	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.4	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.1	PID RHOA PATHWAY	RhoA signaling pathway
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.3	PID IL23 PATHWAY	IL23-mediated signaling events
0.1	PID IL3 PATHWAY	IL3-mediated signaling events
0.3	PID HIF2PATHWAY	HIF-2-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.1	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	1.0	REACTOME SIGNAL TRANSDUCTION BY L1	Genes involved in Signal transduction by L1
0.0	0.3	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.2	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.3	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.2	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.0	0.0	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.4	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.0	0.2	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.5	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.3	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.4	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.5	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.4	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.1	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.5	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	0.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.5	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.2	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.3	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.8	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.2	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.2	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	0.2	REACTOME IL 3 5 AND GM CSF SIGNALING	Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.0	0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.7	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.2	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	0.5	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.1	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.0	REACTOME RNA POL I TRANSCRIPTION	Genes involved in RNA Polymerase I Transcription
0.0	0.2	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.0	0.2	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.2	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.1	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.1	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.1	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.1	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex