CREMA results: ZFHX3

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Transcription factors associated with ZFHX3

Gene Symbol	Gene ID	Gene Info
ZFHX3 Ensembl NCBI GeneCards UniProt	ENSG00000140836.10	zinc finger homeobox 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr16_73080724_73080969	ZFHX3	1428	0.472491	-0.87	2.5e-03	Click!
chr16_73080996_73081147	ZFHX3	1203	0.533635	-0.86	2.6e-03	Click!
chr16_73101800_73101951	ZFHX3	8278	0.243204	-0.83	6.2e-03	Click!
chr16_73102131_73102454	ZFHX3	8695	0.241874	-0.84	5.0e-03	Click!
chr16_73128008_73128159	ZFHX3	34486	0.179269	-0.97	2.0e-05	Click!

Showing 1 to 5 of 5 entries

Activity of the ZFHX3 motif across conditions

Conditions sorted by the z-value of the ZFHX3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_14599434_14599610	0.89	FAM107B	family with sequence similarity 107, member B	1343	0.53
chr6_130537041_130537253	0.82	SAMD3	sterile alpha motif domain containing 3	68	0.98
chr6_20336837_20336988	0.78	E2F3	E2F transcription factor 3	65486	0.1
chr1_198663697_198663875	0.72	RP11-553K8.5		27596	0.22
chr3_186743797_186744281	0.69	ST6GAL1	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	768	0.72
chr1_160576647_160576798	0.66	CD84	CD84 molecule	27416	0.12
chr15_22452071_22452222	0.65	IGHV1OR15-1	immunoglobulin heavy variable 1/OR15-1 (non-functional)	3327	0.16
chr12_104860037_104860188	0.64	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	9333	0.28
chr12_94599007_94599198	0.63	RP11-74K11.2		19282	0.19
chr3_59997046_59997753	0.63	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	39816	0.23

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZFHX3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.0	GO:0006959	humoral immune response(GO:0006959)
0.2	0.9	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.8	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.2	0.6	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.6	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.6	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0	0.6	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.6	GO:0008360	regulation of cell shape(GO:0008360)
0.1	0.5	GO:0000729	DNA double-strand break processing(GO:0000729)
0.1	0.5	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)

Showing 1 to 10 of 243 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.1	0.5	GO:0070688	MLL5-L complex(GO:0070688)
0.1	0.5	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.5	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.1	0.4	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.4	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.4	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.3	GO:0001772	immunological synapse(GO:0001772)
0.0	0.3	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)

Showing 1 to 10 of 71 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.1	0.8	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.8	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.8	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.8	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.5	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.5	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.4	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.4	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.4	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)

Showing 1 to 10 of 153 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
2.6	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
1.0	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
1.0	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.9	PID ILK PATHWAY	Integrin-linked kinase signaling
0.6	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.5	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.5	PID E2F PATHWAY	E2F transcription factor network
0.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.4	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta

Showing 1 to 10 of 43 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.8	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.8	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.8	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.7	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	0.6	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.5	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.5	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.5	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.5	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis

Showing 1 to 10 of 61 entries

Results for ZFHX3

Z-value: 1.53

Motif logo

Transcription factors associated with ZFHX3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the ZFHX3 motif across conditions

Conditions sorted by the z-value of the ZFHX3 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZFHX3

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: