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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZFHX3

Z-value: 1.53

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Transcription factors associated with ZFHX3

Gene Symbol	Gene ID	Gene Info
ZFHX3 Ensembl NCBI GeneCards UniProt	ENSG00000140836.10	ZFHX3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZFHX3	chr16_73128008_73128159	34486	0.179269	-0.97	2.0e-05	Click!
ZFHX3	chr16_73080724_73080969	1428	0.472491	-0.87	2.5e-03	Click!
ZFHX3	chr16_73080996_73081147	1203	0.533635	-0.86	2.6e-03	Click!
ZFHX3	chr16_73102131_73102454	8695	0.241874	-0.84	5.0e-03	Click!
ZFHX3	chr16_73101800_73101951	8278	0.243204	-0.83	6.2e-03	Click!

Activity of the ZFHX3 motif across conditions

Conditions sorted by the z-value of the ZFHX3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_14599434_14599610	0.89	FAM107B	family with sequence similarity 107, member B	1343	0.53
chr6_130537041_130537253	0.82	SAMD3	sterile alpha motif domain containing 3	68	0.98
chr6_20336837_20336988	0.78	E2F3	E2F transcription factor 3	65486	0.1
chr1_198663697_198663875	0.72	RP11-553K8.5		27596	0.22
chr3_186743797_186744281	0.69	ST6GAL1	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	768	0.72
chr1_160576647_160576798	0.66	CD84	CD84 molecule	27416	0.12
chr15_22452071_22452222	0.65	IGHV1OR15-1	immunoglobulin heavy variable 1/OR15-1 (non-functional)	3327	0.16
chr12_104860037_104860188	0.64	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	9333	0.28
chr12_94599007_94599198	0.63	RP11-74K11.2		19282	0.19
chr3_59997046_59997753	0.63	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	39816	0.23
chr16_50720309_50720716	0.63	SNX20	sorting nexin 20	5248	0.13
chr7_37055765_37056093	0.62	ELMO1-AS1	ELMO1 antisense RNA 1	18528	0.2
chr6_111008371_111008642	0.61	ENSG00000200522	.	35045	0.17
chr13_99930486_99930694	0.61	GPR18	G protein-coupled receptor 18	16592	0.18
chr15_62148914_62149135	0.60	RP11-16B9.1		22073	0.23
chr7_1085249_1085400	0.58	GPR146	G protein-coupled receptor 146	1112	0.32
chr8_82015786_82015967	0.58	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	8427	0.3
chr1_109188916_109189073	0.58	HENMT1	HEN1 methyltransferase homolog 1 (Arabidopsis)	14683	0.19
chr13_41543655_41543806	0.57	ELF1	E74-like factor 1 (ets domain transcription factor)	12688	0.19
chr2_213980870_213981021	0.57	IKZF2	IKAROS family zinc finger 2 (Helios)	32408	0.23
chrX_146996931_146997212	0.57	FMR1	fragile X mental retardation 1	3373	0.19
chr1_198639351_198639502	0.57	RP11-553K8.5		3236	0.32
chr9_37302020_37302197	0.57	ENSG00000216070	.	6007	0.22
chr4_78075898_78076211	0.56	CCNG2	cyclin G2	2250	0.33
chr17_74250036_74250213	0.56	UBALD2	UBA-like domain containing 2	11159	0.13
chrX_70754467_70754618	0.55	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase	391	0.86
chr12_106856803_106856954	0.55	POLR3B	polymerase (RNA) III (DNA directed) polypeptide B	81128	0.09
chrX_65207483_65207634	0.55	RP6-159A1.3		12035	0.22
chr7_134837346_134837497	0.53	AC083862.1	Uncharacterized protein	4505	0.16
chr21_36397619_36398181	0.52	RUNX1	runt-related transcription factor 1	23562	0.28
chrX_24516682_24516850	0.52	ENSG00000265506	.	18691	0.19
chr11_48041048_48041486	0.52	AC103828.1		3860	0.26
chr8_19553650_19553834	0.52	CSGALNACT1	chondroitin sulfate N-acetylgalactosaminyltransferase 1	13470	0.29
chr12_62665356_62665507	0.52	USP15	ubiquitin specific peptidase 15	6978	0.22
chr1_114322751_114323179	0.52	PHTF1	putative homeodomain transcription factor 1	20867	0.15
chr8_121714189_121714356	0.51	RP11-713M15.1		59221	0.14
chr12_93834610_93834761	0.50	UBE2N	ubiquitin-conjugating enzyme E2N	347	0.85
chr9_130792035_130792335	0.49	RP11-379C10.1		27456	0.09
chr3_18470958_18471238	0.49	SATB1	SATB homeobox 1	4237	0.24
chr7_13950741_13951075	0.49	ETV1	ets variant 1	75158	0.12
chr13_41540748_41540928	0.49	ELF1	E74-like factor 1 (ets domain transcription factor)	15580	0.18
chr5_80053748_80053899	0.48	DHFR	dihydrofolate reductase	103021	0.06
chr3_107811334_107811485	0.48	CD47	CD47 molecule	1537	0.55
chr1_226918876_226919104	0.48	ITPKB	inositol-trisphosphate 3-kinase B	6169	0.25
chr2_196421409_196421560	0.47	SLC39A10	solute carrier family 39 (zinc transporter), member 10	19217	0.24
chr7_152037629_152037780	0.46	ENSG00000253088	.	62161	0.12
chr22_40738137_40738293	0.45	ADSL	adenylosuccinate lyase	4292	0.22
chr11_3999951_4000538	0.45	STIM1	stromal interaction molecule 1	31671	0.15
chr10_3709420_3709846	0.45	RP11-184A2.3		83626	0.1
chr5_95150906_95151226	0.44	GLRX	glutaredoxin (thioltransferase)	7349	0.16
chr19_33677663_33677957	0.44	LRP3	low density lipoprotein receptor-related protein 3	7680	0.13
chr4_110571544_110571753	0.43	AC004067.5		41512	0.14
chrX_19779868_19780019	0.43	SH3KBP1	SH3-domain kinase binding protein 1	14122	0.29
chr15_64133458_64133609	0.43	HERC1	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	7392	0.23
chr1_8489766_8489917	0.43	RP5-1115A15.1		4143	0.22
chr9_132707070_132707482	0.42	RP11-409K20.6		11461	0.19
chr9_33841783_33842038	0.42	ENSG00000200834	.	10934	0.12
chr5_39185202_39185385	0.42	FYB	FYN binding protein	17836	0.25
chr8_60240556_60240759	0.42	ENSG00000201763	.	127787	0.06
chr1_100910954_100911247	0.42	RP5-837M10.4		40453	0.15
chr7_8013996_8014418	0.42	AC006042.7		4673	0.2
chr12_104868829_104868993	0.41	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	18132	0.25
chr6_143189511_143189662	0.41	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	31402	0.22
chrX_11784442_11784722	0.41	MSL3	male-specific lethal 3 homolog (Drosophila)	6835	0.32
chr2_231508120_231508337	0.41	ENSG00000199791	.	56392	0.11
chr9_33297269_33297449	0.41	NFX1	nuclear transcription factor, X-box binding 1	6816	0.16
chr8_129551445_129551700	0.41	ENSG00000221351	.	280468	0.01
chr11_47787493_47787651	0.41	FNBP4	formin binding protein 4	1281	0.36
chr17_46189481_46189632	0.40	SNX11	sorting nexin 11	245	0.86
chrX_41767743_41767943	0.40	ENSG00000251807	.	10759	0.23
chr22_40307678_40307829	0.40	GRAP2	GRB2-related adaptor protein 2	10640	0.17
chr1_185646518_185646683	0.40	ENSG00000201596	.	43286	0.15
chr1_160611737_160611992	0.40	SLAMF1	signaling lymphocytic activation molecule family member 1	4947	0.18
chr5_174911911_174912232	0.40	SFXN1	sideroflexin 1	6476	0.23
chr18_74294702_74294853	0.40	LINC00908	long intergenic non-protein coding RNA 908	53903	0.13
chr14_22548983_22549134	0.40	ENSG00000238634	.	61829	0.14
chr1_40526792_40526943	0.39	CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	20313	0.16
chr1_198589922_198590135	0.39	PTPRC	protein tyrosine phosphatase, receptor type, C	17773	0.23
chr5_52020219_52020370	0.39	ITGA1	integrin, alpha 1	63436	0.12
chr10_115625916_115626067	0.38	NHLRC2	NHL repeat containing 2	11571	0.17
chr17_40609828_40609979	0.38	ATP6V0A1	ATPase, H+ transporting, lysosomal V0 subunit a1	959	0.38
chr6_20406623_20406774	0.38	E2F3	E2F transcription factor 3	2664	0.22
chr8_109486447_109486598	0.38	EMC2	ER membrane protein complex subunit 2	23862	0.27
chr13_48820347_48820675	0.38	ITM2B	integral membrane protein 2B	13172	0.25
chr2_197005876_197006039	0.38	RP11-347P5.1		10030	0.2
chr15_92401400_92401706	0.37	SLCO3A1	solute carrier organic anion transporter family, member 3A1	4202	0.3
chr8_87360864_87361033	0.37	WWP1	WW domain containing E3 ubiquitin protein ligase 1	5981	0.29
chr7_114612569_114612720	0.37	MDFIC	MyoD family inhibitor domain containing	38720	0.23
chr2_208483981_208484229	0.37	METTL21A	methyltransferase like 21A	4999	0.21
chr4_78727930_78728100	0.37	CNOT6L	CCR4-NOT transcription complex, subunit 6-like	12202	0.26
chr7_43909566_43909799	0.37	MRPS24	mitochondrial ribosomal protein S24	526	0.74
chr20_50145944_50146095	0.36	NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	13239	0.27
chr1_111204078_111204246	0.36	ENSG00000221538	.	8509	0.18
chr17_35960751_35960902	0.36	SYNRG	synergin, gamma	8603	0.17
chr13_48793580_48793731	0.36	ITM2B	integral membrane protein 2B	13639	0.25
chr8_81051643_81051794	0.36	RP11-92K15.1		16631	0.2
chr4_87920133_87920357	0.36	AFF1	AF4/FMR2 family, member 1	7895	0.28
chr12_14444158_14444309	0.36	ENSG00000265119	.	20044	0.2
chr10_48461977_48462183	0.36	GDF10	growth differentiation factor 10	23104	0.17
chr6_45420208_45420439	0.36	RUNX2	runt-related transcription factor 2	30101	0.19
chr11_124495044_124495195	0.35	TBRG1	transforming growth factor beta regulator 1	2326	0.2
chr6_15397672_15397823	0.35	JARID2	jumonji, AT rich interactive domain 2	3342	0.33
chr6_159519338_159519692	0.35	TAGAP	T-cell activation RhoGTPase activating protein	53331	0.11
chr16_53493564_53493875	0.35	RBL2	retinoblastoma-like 2 (p130)	9731	0.16
chr7_6298731_6299016	0.35	CYTH3	cytohesin 3	13402	0.18
chr4_90410089_90410240	0.35	RP11-115D19.1		62343	0.15
chr9_37341093_37341244	0.35	ENSG00000206784	.	18912	0.19
chr17_33372588_33372757	0.35	RFFL	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	3302	0.15
chr17_76006574_76006749	0.35	TNRC6C	trinucleotide repeat containing 6C	5524	0.22
chrX_32217344_32217495	0.35	DMD	dystrophin	43833	0.2
chr15_45001766_45002275	0.35	B2M	beta-2-microglobulin	1655	0.29
chr8_19284492_19284750	0.35	SH2D4A	SH2 domain containing 4A	107520	0.08
chr4_71961249_71961400	0.34	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	91679	0.08
chr9_21983229_21983380	0.34	CDKN2A	cyclin-dependent kinase inhibitor 2A	8207	0.14
chr1_168412623_168412774	0.34	ENSG00000207974	.	67936	0.11
chr5_96294843_96295052	0.34	LNPEP	leucyl/cystinyl aminopeptidase	792	0.61
chr7_98975533_98975728	0.34	ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	3277	0.16
chr16_57502364_57502515	0.34	POLR2C	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	6140	0.13
chr10_21788608_21788824	0.34	CASC10	cancer susceptibility candidate 10	2525	0.18
chr11_118753719_118753870	0.34	CXCR5	chemokine (C-X-C motif) receptor 5	681	0.52
chr8_95955710_95956126	0.34	TP53INP1	tumor protein p53 inducible nuclear protein 1	2717	0.19
chrX_37655630_37655781	0.34	CYBB	cytochrome b-245, beta polypeptide	16388	0.22
chr14_91879240_91879633	0.34	CCDC88C	coiled-coil domain containing 88C	4254	0.28
chr3_101797096_101797247	0.34	ZPLD1	zona pellucida-like domain containing 1	20917	0.26
chr1_220414900_220415051	0.33	RAB3GAP2	RAB3 GTPase activating protein subunit 2 (non-catalytic)	30256	0.17
chr12_12672929_12673156	0.33	DUSP16	dual specificity phosphatase 16	1017	0.63
chr2_204583285_204583561	0.33	CD28	CD28 molecule	12007	0.23
chr3_17379285_17379436	0.33	TBC1D5	TBC1 domain family, member 5	68852	0.14
chr15_59069056_59069207	0.33	FAM63B	family with sequence similarity 63, member B	5570	0.16
chr1_160607664_160607901	0.33	SLAMF1	signaling lymphocytic activation molecule family member 1	9029	0.16
chr18_2579117_2579268	0.33	NDC80	NDC80 kinetochore complex component	1344	0.35
chr6_109357060_109357211	0.33	ENSG00000199944	.	23682	0.16
chr7_130765782_130766079	0.33	LINC-PINT	long intergenic non-protein coding RNA, p53 induced transcript	7303	0.22
chr6_37878002_37878153	0.33	ENSG00000200597	.	5272	0.24
chr14_68758527_68759049	0.33	ENSG00000243546	.	55532	0.15
chr2_225851954_225852161	0.33	ENSG00000263828	.	23200	0.24
chrX_13106601_13106839	0.33	FAM9C	family with sequence similarity 9, member C	43919	0.18
chr12_123844374_123844525	0.32	SBNO1	strawberry notch homolog 1 (Drosophila)	4926	0.16
chrX_135769178_135769446	0.32	CD40LG	CD40 ligand	38926	0.13
chr12_80249075_80249226	0.32	PPP1R12A	protein phosphatase 1, regulatory subunit 12A	17502	0.16
chr4_54277446_54277597	0.32	FIP1L1	factor interacting with PAPOLA and CPSF1	16712	0.22
chr15_45029426_45029577	0.32	TRIM69	tripartite motif containing 69	737	0.62
chr2_234317301_234317452	0.32	DGKD	diacylglycerol kinase, delta 130kDa	20576	0.16
chr17_48948425_48948576	0.32	TOB1	transducer of ERBB2, 1	3161	0.2
chr2_149413727_149414080	0.32	EPC2	enhancer of polycomb homolog 2 (Drosophila)	10914	0.3
chr5_110086965_110087116	0.32	SLC25A46	solute carrier family 25, member 46	3780	0.27
chrX_78200075_78200274	0.32	P2RY10	purinergic receptor P2Y, G-protein coupled, 10	655	0.83
chr8_119322107_119322258	0.32	AC023590.1	Uncharacterized protein	27701	0.27
chr3_43390090_43390241	0.32	RP11-188P20.3		1030	0.5
chr4_78736039_78736190	0.32	CNOT6L	CCR4-NOT transcription complex, subunit 6-like	4103	0.31
chr18_68325321_68325472	0.32	GTSCR1	Gilles de la Tourette syndrome chromosome region, candidate 1	7416	0.33
chr10_22894712_22894863	0.32	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	14145	0.29
chr5_169718242_169718475	0.32	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	6873	0.23
chr17_73365257_73365429	0.32	RP11-16C1.2		4474	0.12
chr4_149352672_149352823	0.31	NR3C2	nuclear receptor subfamily 3, group C, member 2	5265	0.34
chr13_37030668_37030819	0.31	CCNA1	cyclin A1	24248	0.21
chr17_42323284_42323440	0.31	AC003102.1		3874	0.1
chr1_241840160_241840311	0.31	WDR64	WD repeat domain 64	6647	0.23
chr1_100918680_100918971	0.31	RP5-837M10.4		32728	0.17
chr4_140001799_140001950	0.31	ELF2	E74-like factor 2 (ets domain transcription factor)	3470	0.19
chr13_52107424_52107667	0.31	INTS6-AS1	INTS6 antisense RNA 1	8149	0.14
chr6_36005080_36005248	0.31	MAPK14	mitogen-activated protein kinase 14	8298	0.19
chr14_61883865_61884124	0.31	PRKCH	protein kinase C, eta	25282	0.21
chr22_44850826_44850977	0.31	LDOC1L	leucine zipper, down-regulated in cancer 1-like	43277	0.18
chr12_67920194_67920345	0.30	DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	121849	0.06
chr17_25784455_25784823	0.30	KSR1	kinase suppressor of ras 1	899	0.6
chr5_130613996_130614147	0.30	CDC42SE2	CDC42 small effector 2	14278	0.28
chr6_99938862_99939169	0.30	USP45	ubiquitin specific peptidase 45	8274	0.18
chr5_130587781_130588081	0.30	CDC42SE2	CDC42 small effector 2	11771	0.27
chr6_24957255_24957453	0.30	FAM65B	family with sequence similarity 65, member B	21166	0.2
chr1_65475101_65475369	0.30	ENSG00000212257	.	13522	0.19
chr14_61814414_61814719	0.30	PRKCH	protein kinase C, eta	43	0.98
chr15_49999697_49999848	0.30	RP11-353B9.1		55436	0.13
chr2_103016581_103016795	0.30	IL18RAP	interleukin 18 receptor accessory protein	18461	0.14
chr1_198661100_198661367	0.30	RP11-553K8.5		25043	0.23
chrX_30593744_30593895	0.30	CXorf21	chromosome X open reading frame 21	2142	0.39
chr2_48557371_48557557	0.30	ENSG00000251889	.	10501	0.22
chr2_145276991_145277142	0.30	ZEB2-AS1	ZEB2 antisense RNA 1	115	0.87
chr2_169961679_169961830	0.30	AC007556.3		4501	0.26
chr3_33086671_33086822	0.30	GLB1	galactosidase, beta 1	51538	0.11
chr5_171368623_171368774	0.30	FBXW11	F-box and WD repeat domain containing 11	36062	0.19
chr3_71410535_71410686	0.30	FOXP1	forkhead box P1	56699	0.15
chr16_71914316_71914975	0.30	ZNF821	zinc finger protein 821	677	0.52
chr5_100234402_100234890	0.29	ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	4272	0.34
chr5_169718890_169719042	0.29	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	6265	0.24
chr20_1639703_1639854	0.29	SIRPG	signal-regulatory protein gamma	1353	0.36
chr6_88467574_88467725	0.29	ENSG00000238628	.	37016	0.15
chr1_172670656_172670827	0.29	FASLG	Fas ligand (TNF superfamily, member 6)	42583	0.18
chr12_52745258_52745409	0.29	KRT85	keratin 85	13073	0.09
chrX_119740205_119740356	0.29	MCTS1	malignant T cell amplified sequence 1	2104	0.31
chr6_12071674_12071825	0.29	HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	54230	0.16
chr22_41503197_41503348	0.29	ENSG00000221160	.	14755	0.12
chr10_63150600_63150931	0.29	TMEM26	transmembrane protein 26	40325	0.19
chr14_61844385_61844536	0.29	PRKCH	protein kinase C, eta	12952	0.23
chr12_11919657_11920091	0.29	ETV6	ets variant 6	14439	0.28
chr6_143165210_143165407	0.29	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	7124	0.3
chr5_78556716_78556867	0.29	JMY	junction mediating and regulatory protein, p53 cofactor	24779	0.17
chr1_203282441_203282646	0.29	ENSG00000202300	.	5684	0.18
chr12_94545765_94545930	0.29	PLXNC1	plexin C1	3348	0.28
chr10_124759466_124759617	0.29	IKZF5	IKAROS family zinc finger 5 (Pegasus)	8792	0.16

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZFHX3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.9	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.2	0.6	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.5	GO:0000729	DNA double-strand break processing(GO:0000729)
0.1	0.2	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	0.3	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.2	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.8	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.1	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.1	0.5	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.1	0.6	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1	0.4	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.2	GO:0090266	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.1	0.2	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.2	GO:0007100	mitotic centrosome separation(GO:0007100)
0.1	0.3	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.2	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.3	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.2	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0033345	asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0	0.2	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.1	GO:0042663	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.2	GO:0002335	mature B cell differentiation(GO:0002335)
0.0	0.2	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.2	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.2	GO:0071636	positive regulation of transforming growth factor beta production(GO:0071636)
0.0	0.2	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.0	GO:0001779	natural killer cell differentiation(GO:0001779)
0.0	0.0	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.3	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.0	GO:0002888	positive regulation of myeloid leukocyte mediated immunity(GO:0002888)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0046666	retinal cell programmed cell death(GO:0046666)
0.0	0.1	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0045348	positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0	0.1	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.3	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.3	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	0.0	GO:0032966	negative regulation of collagen biosynthetic process(GO:0032966)
0.0	0.3	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.4	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.2	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.1	GO:0019532	oxalate transport(GO:0019532)
0.0	0.2	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.2	GO:0002478	antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0	0.1	GO:0006545	glycine biosynthetic process(GO:0006545)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0050932	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.0	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.0	0.1	GO:0072124	glomerular mesangial cell proliferation(GO:0072110) regulation of glomerular mesangial cell proliferation(GO:0072124)
0.0	0.0	GO:0002448	mast cell mediated immunity(GO:0002448)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0033033	negative regulation of myeloid cell apoptotic process(GO:0033033)
0.0	0.1	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0051532	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.2	GO:0048535	lymph node development(GO:0048535)
0.0	0.0	GO:0051497	negative regulation of actin filament bundle assembly(GO:0032232) negative regulation of stress fiber assembly(GO:0051497)
0.0	0.6	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.1	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.0	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.0	GO:0007549	dosage compensation(GO:0007549)
0.0	0.0	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.1	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0045423	regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.0	0.3	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.6	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.1	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.2	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.2	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.5	GO:0045576	mast cell activation(GO:0045576)
0.0	0.5	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.1	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.0	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0071168	protein localization to chromatin(GO:0071168)
0.0	0.0	GO:0002707	negative regulation of lymphocyte mediated immunity(GO:0002707)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.0	GO:0006591	ornithine metabolic process(GO:0006591)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.0	GO:1903312	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.2	GO:0044409	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.1	GO:2000330	T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) memory T cell differentiation(GO:0043379) regulation of memory T cell differentiation(GO:0043380) positive regulation of memory T cell differentiation(GO:0043382) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540) regulation of T-helper 17 type immune response(GO:2000316) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 17 cell differentiation(GO:2000319) positive regulation of T-helper 17 cell differentiation(GO:2000321) regulation of T-helper 17 cell lineage commitment(GO:2000328) positive regulation of T-helper 17 cell lineage commitment(GO:2000330)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0032814	regulation of natural killer cell activation(GO:0032814)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.2	GO:0046519	sphingoid metabolic process(GO:0046519)
0.0	0.1	GO:0031274	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.1	GO:0009223	pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0	0.2	GO:0007141	male meiosis I(GO:0007141)
0.0	0.1	GO:0043247	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.1	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.0	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.1	GO:0003099	positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0	0.1	GO:0030186	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.2	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.1	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.3	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.0	GO:0016093	polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.0	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.0	GO:2001234	negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0	0.1	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.0	0.1	GO:0001514	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.0	GO:1904251	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0	0.1	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.0	0.0	GO:1903306	negative regulation of regulated secretory pathway(GO:1903306)
0.0	0.2	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.0	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0010988	regulation of low-density lipoprotein particle clearance(GO:0010988)
0.0	0.0	GO:0008340	determination of adult lifespan(GO:0008340)
0.0	0.0	GO:0051569	regulation of histone H3-K4 methylation(GO:0051569)
0.0	0.0	GO:0046874	quinolinate metabolic process(GO:0046874)
0.0	0.0	GO:0010587	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0048070	regulation of developmental pigmentation(GO:0048070)
0.0	0.0	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.0	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.0	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.0	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.1	GO:0042976	activation of Janus kinase activity(GO:0042976)
0.0	0.0	GO:0001787	natural killer cell proliferation(GO:0001787)
0.0	0.0	GO:0032070	regulation of deoxyribonuclease activity(GO:0032070)
0.0	0.1	GO:0032878	regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0	0.1	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.0	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.0	GO:0021860	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.2	GO:0008299	isoprenoid biosynthetic process(GO:0008299)
0.0	0.0	GO:0045910	negative regulation of DNA recombination(GO:0045910)
0.0	0.0	GO:0044803	multi-organism membrane organization(GO:0044803)
0.0	0.1	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.1	GO:0060396	growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0	0.0	GO:0033079	immature T cell proliferation(GO:0033079)
0.0	0.0	GO:1902745	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0000050	urea cycle(GO:0000050)
0.0	0.1	GO:1902221	L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0	0.0	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.0	GO:2000143	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.0	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0051001	negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0	0.1	GO:0006534	cysteine metabolic process(GO:0006534)
0.0	0.1	GO:0031648	protein destabilization(GO:0031648)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	1.0	GO:0006959	humoral immune response(GO:0006959)
0.0	0.2	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	0.1	GO:0042403	thyroid hormone metabolic process(GO:0042403)
0.0	0.1	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	0.0	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.2	GO:0030838	positive regulation of actin filament polymerization(GO:0030838)
0.0	0.0	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.0	GO:0051447	negative regulation of meiotic cell cycle(GO:0051447)
0.0	0.0	GO:0090224	regulation of spindle organization(GO:0090224)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.1	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.5	GO:0070646	protein modification by small protein removal(GO:0070646)
0.0	0.0	GO:2000351	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.0	GO:0032261	purine nucleotide salvage(GO:0032261)
0.0	0.0	GO:0031498	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.0	GO:0046950	cellular ketone body metabolic process(GO:0046950)
0.0	0.2	GO:0030317	sperm motility(GO:0030317)
0.0	0.0	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.0	GO:0060605	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.1	GO:0006241	GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051)
0.0	0.5	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.0	GO:0046132	pyrimidine ribonucleoside biosynthetic process(GO:0046132)
0.0	0.0	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.0	GO:0032328	alanine transport(GO:0032328)
0.0	0.2	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.3	GO:0072512	ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.0	0.0	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.2	GO:0006541	glutamine metabolic process(GO:0006541)
0.0	0.0	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.0	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.6	GO:0008360	regulation of cell shape(GO:0008360)
0.0	0.1	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.0	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.1	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.0	GO:0007008	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.0	GO:0071680	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0	0.1	GO:0042891	tetracycline transport(GO:0015904) antibiotic transport(GO:0042891) toxin transport(GO:1901998)
0.0	0.1	GO:0006744	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.0	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.0	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.0	GO:0015669	gas transport(GO:0015669)
0.0	0.0	GO:0009188	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.0	GO:0035092	sperm chromatin condensation(GO:0035092)
0.0	0.0	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0046689	response to mercury ion(GO:0046689)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.1	0.5	GO:0070688	MLL5-L complex(GO:0070688)
0.1	0.2	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1	0.5	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.2	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.4	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.2	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.1	GO:0017071	intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0	0.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.3	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.4	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.2	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.9	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0044453	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0045239	tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0	0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.1	GO:0042584	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.1	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.1	GO:0001741	XY body(GO:0001741)
0.0	0.1	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.3	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.5	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.2	GO:0008278	cohesin complex(GO:0008278)
0.0	0.2	GO:0043186	P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0	0.1	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.1	GO:0045283	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.0	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.3	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.0	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0016585	obsolete chromatin remodeling complex(GO:0016585)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.0	GO:0033185	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.0	GO:0070695	FHF complex(GO:0070695)
0.0	0.2	GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177)
0.0	0.1	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.1	GO:0005838	proteasome regulatory particle(GO:0005838)
0.0	0.1	GO:0042627	chylomicron(GO:0042627)
0.0	0.3	GO:0030175	filopodium(GO:0030175)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.0	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.2	GO:0005801	cis-Golgi network(GO:0005801)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.3	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	0.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.2	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.1	0.2	GO:0042608	T cell receptor binding(GO:0042608)
0.1	0.2	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.1	0.3	GO:0005131	growth hormone receptor binding(GO:0005131)
0.1	0.2	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.2	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1	0.2	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.1	0.8	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.3	GO:0008494	translation activator activity(GO:0008494)
0.0	0.3	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.1	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.8	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.3	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.5	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.8	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.3	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.1	GO:0060229	phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.2	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.2	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.4	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.2	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.4	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	1.1	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.2	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.0	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.5	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.4	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.8	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.0	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.0	GO:0035240	dopamine binding(GO:0035240)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.2	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	0.1	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.3	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.3	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.0	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.1	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0	0.1	GO:0099528	dopamine neurotransmitter receptor activity(GO:0004952) G-protein coupled neurotransmitter receptor activity(GO:0099528)
0.0	0.0	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.4	GO:0003823	antigen binding(GO:0003823)
0.0	0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.0	GO:0036041	long-chain fatty acid binding(GO:0036041)
0.0	0.2	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.0	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.0	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.2	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.0	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.0	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.2	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.4	GO:0043130	ubiquitin binding(GO:0043130)
0.0	0.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.2	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0004457	lactate dehydrogenase activity(GO:0004457)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.1	GO:0000104	succinate dehydrogenase activity(GO:0000104)
0.0	0.1	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0016273	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0070061	fructose binding(GO:0070061)
0.0	0.2	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.0	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.1	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.2	GO:0004190	aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0	0.2	GO:0003756	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	0.0	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.4	GO:0004221	obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0	0.2	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.0	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.2	GO:0043621	protein self-association(GO:0043621)
0.0	0.0	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.2	GO:0051219	phosphoprotein binding(GO:0051219)
0.0	0.2	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.0	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.0	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.0	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.3	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	0.0	GO:0003747	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.4	GO:0008375	acetylglucosaminyltransferase activity(GO:0008375)
0.0	0.0	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.0	GO:0035014	phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0	0.1	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.2	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0	0.0	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.0	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0046625	sphingolipid binding(GO:0046625)
0.0	0.0	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.0	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.0	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
2.6	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
1.0	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.5	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
1.0	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.4	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.6	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.9	PID ILK PATHWAY	Integrin-linked kinase signaling
0.2	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.3	PID MYC PATHWAY	C-MYC pathway
0.4	PID IL1 PATHWAY	IL1-mediated signaling events
0.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	PID TNF PATHWAY	TNF receptor signaling pathway
0.2	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	PID IFNG PATHWAY	IFN-gamma pathway
0.2	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.2	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.4	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.2	PID IL3 PATHWAY	IL3-mediated signaling events
0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.4	PID PLK1 PATHWAY	PLK1 signaling events
0.1	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.1	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.2	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.5	PID E2F PATHWAY	E2F transcription factor network
0.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.6	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.1	0.8	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	0.4	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.5	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.5	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.7	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.8	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.5	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.1	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.3	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.8	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.5	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.5	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.0	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.1	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.3	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0	0.2	REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0	0.2	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	0.4	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.0	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.0	REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0	0.4	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.1	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.1	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.1	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.1	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.1	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.1	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.1	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.2	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.2	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.1	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.1	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.4	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	0.0	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	0.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.1	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.1	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.0	0.0	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.0	0.3	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.3	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.1	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.1	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.0	0.2	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	0.0	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.2	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters