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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for ZIC2_GLI1

Z-value: 0.59

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Transcription factors associated with ZIC2_GLI1

Gene Symbol	Gene ID	Gene Info
ZIC2 Ensembl NCBI GeneCards UniProt	ENSG00000043355.6	Zic family member 2
GLI1 Ensembl NCBI GeneCards UniProt	ENSG00000111087.5	GLI family zinc finger 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr12_57854196_57854445	GLI1	46	0.938437	-0.59	9.4e-02	Click!
chr12_57855026_57855259	GLI1	868	0.360981	-0.49	1.8e-01	Click!
chr12_57855717_57856166	GLI1	1534	0.193930	-0.40	2.9e-01	Click!
chr12_57853153_57853708	GLI1	488	0.601516	-0.38	3.2e-01	Click!
chr12_57855309_57855460	GLI1	1110	0.275992	-0.34	3.7e-01	Click!
chr13_100632410_100632783	ZIC2	1430	0.406983	-0.80	8.9e-03	Click!
chr13_100634648_100635004	ZIC2	800	0.627942	-0.68	4.6e-02	Click!
chr13_100635035_100635186	ZIC2	1084	0.507643	-0.67	4.6e-02	Click!
chr13_100631814_100632089	ZIC2	2075	0.305579	-0.66	5.4e-02	Click!
chr13_100633451_100633876	ZIC2	363	0.867073	-0.64	6.3e-02	Click!

Activity of the ZIC2_GLI1 motif across conditions

Conditions sorted by the z-value of the ZIC2_GLI1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr21_39617669_39617820	0.39	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	10919	0.26
chr6_52475238_52475389	0.32	TRAM2	translocation associated membrane protein 2	33600	0.17
chr3_27576510_27576661	0.29	ENSG00000238912	.	12764	0.2
chr1_95257800_95258262	0.28	SLC44A3	solute carrier family 44, member 3	27867	0.18
chr9_36625036_36625242	0.28	MELK	maternal embryonic leucine zipper kinase	52231	0.16
chr6_37093849_37094027	0.27	PIM1	pim-1 oncogene	44041	0.13
chr17_79057073_79057372	0.26	BAIAP2	BAI1-associated protein 2	3039	0.17
chr6_16801385_16801811	0.25	RP1-151F17.1		39455	0.18
chr8_123527926_123528077	0.24	ENSG00000238901	.	155529	0.04
chr5_150400042_150400772	0.24	GPX3	glutathione peroxidase 3 (plasma)	240	0.93
chr14_73706789_73707006	0.22	PAPLN	papilin, proteoglycan-like sulfated glycoprotein	564	0.69
chr2_12013931_12014082	0.21	ENSG00000265172	.	36894	0.17
chr11_69795112_69795263	0.21	ANO1-AS2	ANO1 antisense RNA 2 (head to head)	126267	0.04
chr16_88839995_88840537	0.20	PIEZO1	piezo-type mechanosensitive ion channel component 1	11353	0.09
chr5_179341315_179341544	0.20	TBC1D9B	TBC1 domain family, member 9B (with GRAM domain)	6570	0.16
chr18_52820659_52820810	0.20	ENSG00000252437	.	6858	0.3
chr2_173991432_173991997	0.20	MLTK	Mitogen-activated protein kinase kinase kinase MLT	36367	0.18
chr1_38587427_38587578	0.20	ENSG00000265596	.	32599	0.17
chr1_41965874_41966025	0.19	EDN2	endothelin 2	15607	0.19
chr12_120933579_120933730	0.19	DYNLL1-AS1	DYNLL1 antisense RNA 1	89	0.65
chr14_70227367_70227518	0.19	SRSF5	serine/arginine-rich splicing factor 5	6368	0.23
chr12_4773711_4773869	0.19	NDUFA9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa	11123	0.15
chr14_103006186_103006337	0.19	ENSG00000266015	.	280	0.9
chr17_10100992_10101234	0.19	GAS7	growth arrest-specific 7	755	0.71
chr1_858767_859188	0.19	SAMD11	sterile alpha motif domain containing 11	1283	0.3
chr6_163148998_163149579	0.18	PACRG	PARK2 co-regulated	295	0.67
chr15_36654222_36654373	0.18	C15orf41	chromosome 15 open reading frame 41	217515	0.02
chr1_220863452_220864325	0.18	C1orf115	chromosome 1 open reading frame 115	701	0.71
chr3_11391565_11391730	0.18	ATG7	autophagy related 7	14484	0.28
chr8_8503148_8503299	0.18	ENSG00000264445	.	12249	0.23
chr16_29836315_29836998	0.18	MVP	major vault protein	4010	0.08
chr18_24022178_24022329	0.17	ENSG00000207160	.	75883	0.1
chr19_35496336_35496487	0.17	GRAMD1A	GRAM domain containing 1A	5051	0.11
chr19_1017328_1017803	0.17	TMEM259	transmembrane protein 259	143	0.89
chr4_157852774_157852925	0.17	PDGFC	platelet derived growth factor C	39206	0.17
chr11_65682854_65683231	0.17	C11orf68	chromosome 11 open reading frame 68	2789	0.12
chr1_22209366_22209608	0.17	HSPG2	heparan sulfate proteoglycan 2	5727	0.21
chr11_35953574_35953793	0.17	LDLRAD3	low density lipoprotein receptor class A domain containing 3	11848	0.18
chr1_205115054_205115205	0.17	RBBP5	retinoblastoma binding protein 5	23986	0.16
chr10_126830022_126830361	0.17	CTBP2	C-terminal binding protein 2	17094	0.26
chr1_38945946_38946097	0.17	ENSG00000200796	.	83690	0.1
chr20_43037764_43037915	0.16	ENSG00000266151	.	1079	0.33
chr4_152405646_152405797	0.16	FAM160A1	family with sequence similarity 160, member A1	1960	0.42
chr2_118883182_118883333	0.16	INSIG2	insulin induced gene 2	37207	0.19
chr3_188994860_188995296	0.16	TPRG1-AS2	TPRG1 antisense RNA 2	36695	0.21
chr9_138947554_138948458	0.16	NACC2	NACC family member 2, BEN and BTB (POZ) domain containing	5580	0.24
chrX_133804180_133804468	0.16	PLAC1	placenta-specific 1	11811	0.21
chr17_80192804_80193076	0.16	SLC16A3	solute carrier family 16 (monocarboxylate transporter), member 3	11	0.96
chr3_71864795_71864946	0.16	ENSG00000239250	.	11458	0.21
chr4_84285334_84285485	0.16	HPSE	heparanase	29103	0.19
chr5_78051704_78051855	0.16	LHFPL2	lipoma HMGIC fusion partner-like 2	107131	0.07
chr6_131323866_131324017	0.15	EPB41L2	erythrocyte membrane protein band 4.1-like 2	2034	0.47
chr6_150623249_150623400	0.15	ENSG00000201628	.	24575	0.21
chr17_1971701_1971993	0.15	HIC1	hypermethylated in cancer 1	12243	0.09
chr3_37932792_37933048	0.15	CTDSPL	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like	29255	0.15
chr10_96034565_96034716	0.15	PLCE1-AS1	PLCE1 antisense RNA 1	12164	0.19
chr12_125550229_125550908	0.15	AACS	acetoacetyl-CoA synthetase	581	0.82
chr16_85160354_85160505	0.15	FAM92B	family with sequence similarity 92, member B	14315	0.21
chr7_130131394_130131755	0.15	MEST	mesoderm specific transcript	360	0.78
chr5_37722434_37722606	0.15	ENSG00000206743	.	21981	0.23
chr6_35461097_35461248	0.14	TEAD3	TEA domain family member 3	3555	0.21
chr19_732760_732911	0.14	MISP	mitotic spindle positioning	18291	0.09
chr14_88217881_88218032	0.14	GALC	galactosylceramidase	241226	0.02
chr2_97513815_97513966	0.14	ANKRD23	ankyrin repeat domain 23	4119	0.15
chr22_44555485_44555636	0.14	PARVG	parvin, gamma	13276	0.26
chr12_50190526_50190677	0.14	NCKAP5L	NCK-associated protein 5-like	184	0.94
chr4_82177498_82177708	0.14	PRKG2	protein kinase, cGMP-dependent, type II	41385	0.18
chr5_171057316_171057470	0.14	ENSG00000264303	.	140141	0.04
chrX_143217715_143217866	0.14	UBE2NL	ubiquitin-conjugating enzyme E2N-like	250617	0.02
chr7_2874138_2874289	0.14	GNA12	guanine nucleotide binding protein (G protein) alpha 12	9437	0.26
chr5_146783504_146783765	0.14	CTB-108O6.2		2311	0.31
chr16_54966944_54967095	0.13	IRX5	iroquois homeobox 5	1035	0.7
chr7_129305011_129305162	0.13	NRF1	nuclear respiratory factor 1	7895	0.23
chr12_9472275_9472568	0.13	ENSG00000212440	.	33003	0.16
chr2_144713214_144713365	0.13	AC016910.1		18649	0.25
chr12_66393056_66393407	0.13	RP11-366L20.3		50972	0.12
chr12_26427261_26427559	0.13	RP11-283G6.5		2557	0.31
chr14_75920905_75921056	0.13	JDP2	Jun dimerization protein 2	22143	0.17
chr2_88203324_88203475	0.13	RGPD2	RANBP2-like and GRIP domain containing 2	77928	0.09
chr3_53106977_53107358	0.13	ENSG00000266635	.	20153	0.16
chr1_9291920_9292071	0.13	H6PD	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	2839	0.28
chr3_185463575_185463764	0.13	ENSG00000265470	.	22023	0.19
chr8_144922026_144922763	0.13	NRBP2	nuclear receptor binding protein 2	408	0.7
chr10_104221677_104221977	0.13	TMEM180	transmembrane protein 180	657	0.51
chr15_64572463_64572614	0.13	ENSG00000252774	.	62200	0.09
chr1_21916647_21916859	0.12	ENSG00000221781	.	2288	0.25
chr1_202825022_202825173	0.12	RP11-480I12.5		3130	0.17
chr3_171865088_171865375	0.12	FNDC3B	fibronectin type III domain containing 3B	20467	0.25
chr20_1852587_1852738	0.12	SIRPA	signal-regulatory protein alpha	22492	0.22
chr16_68368214_68368400	0.12	ENSG00000222177	.	4875	0.11
chr2_237653499_237653650	0.12	ACKR3	atypical chemokine receptor 3	175290	0.03
chr17_40834813_40835091	0.12	CCR10	chemokine (C-C motif) receptor 10	130	0.71
chr2_47564059_47564230	0.12	EPCAM	epithelial cell adhesion molecule	8153	0.19
chr9_36859369_36859520	0.12	RP11-344B23.2		2892	0.23
chr6_1821074_1821225	0.12	FOXC1	forkhead box C1	210468	0.02
chr2_172974903_172975054	0.12	DLX2	distal-less homeobox 2	7350	0.21
chr4_56212156_56212324	0.12	SRD5A3	steroid 5 alpha-reductase 3	36	0.98
chr16_73102653_73102971	0.12	ZFHX3	zinc finger homeobox 3	9215	0.24
chrX_140270368_140270761	0.12	LDOC1	leucine zipper, down-regulated in cancer 1	746	0.65
chr17_14651949_14652297	0.12	HS3ST3B1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	447723	0.01
chr2_120018753_120018963	0.12	STEAP3-AS1	STEAP3 antisense RNA 1	12211	0.19
chr19_56135251_56135453	0.12	ZNF784	zinc finger protein 784	580	0.48
chr2_103511305_103511456	0.12	TMEM182	transmembrane protein 182	132908	0.05
chr2_238624172_238624755	0.12	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1	23481	0.2
chr15_38117070_38117334	0.12	TMCO5A	transmembrane and coiled-coil domains 5A	96938	0.09
chr16_2302179_2302431	0.11	ECI1	enoyl-CoA delta isomerase 1	4	0.91
chr16_85946040_85946191	0.11	IRF8	interferon regulatory factor 8	1465	0.49
chr14_25591053_25591204	0.11	STXBP6	syntaxin binding protein 6 (amisyn)	71625	0.13
chr14_93527679_93527830	0.11	ITPK1	inositol-tetrakisphosphate 1-kinase	4949	0.22
chr5_96001162_96001313	0.11	CAST	calpastatin	2480	0.28
chr2_64699079_64699230	0.11	LGALSL	lectin, galactoside-binding-like	17478	0.18
chr10_88730076_88730664	0.11	RP11-96C23.15		213	0.74
chr9_71180478_71180629	0.11	TMEM252	transmembrane protein 252	24770	0.23
chr14_69394581_69394867	0.11	ACTN1	actinin, alpha 1	19541	0.21
chr1_203032220_203032452	0.11	PPFIA4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	9462	0.13
chr9_137262651_137262802	0.11	ENSG00000263897	.	8531	0.25
chr20_30194564_30194715	0.11	ENSG00000264395	.	350	0.77
chr1_229228845_229228996	0.11	RP5-1061H20.5		134389	0.04
chr9_35604415_35605122	0.11	TESK1	testis-specific kinase 1	599	0.54
chr14_74968488_74968639	0.11	NPC2	Niemann-Pick disease, type C2	7683	0.15
chr20_10589730_10589881	0.11	JAG1	jagged 1	53349	0.15
chr19_43860021_43860172	0.11	CD177	CD177 molecule	2271	0.26
chr3_49590959_49591457	0.11	BSN	bassoon presynaptic cytomatrix protein	714	0.65
chr22_43301928_43302097	0.10	PACSIN2	protein kinase C and casein kinase substrate in neurons 2	39867	0.15
chr1_44359454_44359605	0.10	ST3GAL3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	5731	0.17
chr10_102288134_102289261	0.10	HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	132	0.88
chr16_87715628_87715779	0.10	AC010536.1	Uncharacterized protein; cDNA FLJ45526 fis, clone BRTHA2027227	14050	0.17
chr1_97030873_97031024	0.10	ENSG00000241992	.	17817	0.28
chr10_133999367_134000256	0.10	RP11-140A10.3		345	0.67
chr22_31502446_31502597	0.10	SELM	Selenoprotein M	1033	0.37
chrX_134185283_134186016	0.10	FAM127B	family with sequence similarity 127, member B	556	0.74
chr5_97550623_97550774	0.10	ENSG00000223053	.	424237	0.01
chr9_89591706_89591857	0.10	GAS1	growth arrest-specific 1	29677	0.25
chr14_103739694_103740051	0.10	RP11-45P15.4		58832	0.09
chr10_5617233_5617384	0.10	CALML3-AS1	CALML3 antisense RNA 1	49099	0.09
chr7_8092160_8092311	0.10	AC006042.6		61420	0.11
chr1_3285947_3286098	0.10	PRDM16	PR domain containing 16	27033	0.21
chr13_43859080_43859231	0.10	ENOX1	ecto-NOX disulfide-thiol exchanger 1	76058	0.13
chr2_42651162_42651313	0.10	ENSG00000221300	.	16280	0.21
chr16_3293109_3293260	0.10	ZNF200	zinc finger protein 200	6963	0.1
chr10_60514271_60514422	0.10	BICC1	bicaudal C homolog 1 (Drosophila)	38949	0.22
chr13_114540098_114540530	0.10	GAS6	growth arrest-specific 6	1297	0.5
chr16_57034102_57034447	0.10	NLRC5	NLR family, CARD domain containing 5	3491	0.17
chr17_17881945_17882129	0.10	LRRC48	leucine rich repeat containing 48	5761	0.15
chr10_118892258_118892511	0.10	VAX1	ventral anterior homeobox 1	5183	0.19
chr2_64899791_64900044	0.10	SERTAD2	SERTA domain containing 2	18870	0.22
chr1_17520298_17520449	0.10	PADI1	peptidyl arginine deiminase, type I	11248	0.17
chr9_95873040_95873199	0.10	C9orf89	chromosome 9 open reading frame 89	14619	0.15
chr5_88340795_88340946	0.10	MEF2C-AS1	MEF2C antisense RNA 1	79178	0.12
chr5_36693133_36693338	0.10	CTD-2353F22.1		32040	0.22
chr1_118644337_118644488	0.10	SPAG17	sperm associated antigen 17	83434	0.1
chr6_35393359_35394053	0.10	FANCE	Fanconi anemia, complementation group E	26432	0.15
chr6_123031592_123031771	0.09	PKIB	protein kinase (cAMP-dependent, catalytic) inhibitor beta	7025	0.24
chr19_45959219_45959447	0.09	ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)	5350	0.12
chr20_44638017_44638168	0.09	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	545	0.67
chr5_147781123_147781294	0.09	FBXO38	F-box protein 38	6933	0.18
chr11_126216427_126216820	0.09	ST3GAL4	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	8932	0.14
chr15_57109611_57109762	0.09	ZNF280D	zinc finger protein 280D	83402	0.1
chr2_201535042_201535193	0.09	AOX1	aldehyde oxidase 1	7487	0.23
chr15_80706158_80706309	0.09	ARNT2	aryl-hydrocarbon receptor nuclear translocator 2	9540	0.19
chr12_11733293_11733560	0.09	ENSG00000251747	.	34013	0.16
chr5_34023864_34024015	0.09	AMACR	alpha-methylacyl-CoA racemase	15719	0.18
chr11_70073277_70073428	0.09	RP11-805J14.5		19856	0.13
chr15_90936797_90937093	0.09	RP11-154B12.3		4168	0.17
chr1_21194615_21194766	0.09	ENSG00000251914	.	26956	0.16
chr2_225085875_225086167	0.09	ENSG00000211987	.	18252	0.28
chr18_56554770_56555263	0.09	ZNF532	zinc finger protein 532	22230	0.17
chr13_46076174_46076325	0.09	COG3	component of oligomeric golgi complex 3	37189	0.14
chr12_40552597_40552758	0.09	LRRK2	leucine-rich repeat kinase 2	37869	0.17
chr17_44841951_44842102	0.09	NSF	N-ethylmaleimide-sensitive factor	38104	0.15
chr16_66440801_66441158	0.09	CDH5	cadherin 5, type 2 (vascular endothelium)	11621	0.17
chr4_26240278_26240429	0.09	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	33876	0.24
chr5_43772686_43772978	0.09	NNT	nicotinamide nucleotide transhydrogenase	127373	0.05
chr9_107878597_107878922	0.09	ENSG00000201583	.	19722	0.26
chr1_214466045_214466196	0.09	SMYD2	SET and MYND domain containing 2	11544	0.28
chr1_178252640_178252859	0.09	RASAL2	RAS protein activator like 2	57857	0.16
chr16_69951449_69951738	0.09	WWP2	WW domain containing E3 ubiquitin protein ligase 2	7300	0.16
chr17_79777515_79777666	0.09	FAM195B	family with sequence similarity 195, member B	4773	0.08
chr4_48226478_48226629	0.09	TEC	tec protein tyrosine kinase	45328	0.14
chr21_37296503_37296654	0.09	FKSG68		25851	0.19
chr8_134472381_134472532	0.09	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	16391	0.28
chr7_69119614_69119794	0.08	AUTS2	autism susceptibility candidate 2	55107	0.16
chr9_140541020_140541171	0.08	EHMT1	euchromatic histone-lysine N-methyltransferase 1	27641	0.12
chr6_111894573_111894724	0.08	TRAF3IP2-AS1	TRAF3IP2 antisense RNA 1	1174	0.46
chr8_6086772_6086923	0.08	RP11-115C21.2		177216	0.03
chr9_137257719_137258146	0.08	ENSG00000263897	.	13325	0.24
chr11_36035998_36036518	0.08	ENSG00000263389	.	4610	0.26
chr20_42378949_42379100	0.08	GTSF1L	gametocyte specific factor 1-like	23386	0.19
chr10_122175337_122175488	0.08	PPAPDC1A	phosphatidic acid phosphatase type 2 domain containing 1A	41054	0.18
chr7_73869059_73869441	0.08	GTF2IRD1	GTF2I repeat domain containing 1	811	0.66
chr17_48357099_48357487	0.08	TMEM92	transmembrane protein 92	5505	0.14
chr9_110925898_110926343	0.08	ENSG00000222512	.	195089	0.03
chr3_141679702_141679973	0.08	TFDP2	transcription factor Dp-2 (E2F dimerization partner 2)	2840	0.29
chr4_73843280_73843431	0.08	ENSG00000252955	.	12460	0.25
chr9_129135099_129135415	0.08	MVB12B	multivesicular body subunit 12B	3465	0.28
chrX_53713767_53714068	0.08	HUWE1	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	244	0.95
chr1_234791884_234792035	0.08	IRF2BP2	interferon regulatory factor 2 binding protein 2	46688	0.14
chr22_19692388_19692539	0.08	SEPT5	septin 5	9524	0.18
chr8_143852944_143853095	0.08	LYNX1	Ly6/neurotoxin 1	1757	0.19
chr8_146077548_146078058	0.08	COMMD5	COMM domain containing 5	239	0.83

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC2_GLI1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.1	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.1	GO:0016093	polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0003099	positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0	0.1	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.1	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.1	GO:0000422	mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0	0.0	GO:0010834	obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.0	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.0	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.1	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.1	GO:0015871	choline transport(GO:0015871)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	GO:0030934	anchoring collagen complex(GO:0030934)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.2	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.1	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.2	GO:1900750	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	GO:0004470	malic enzyme activity(GO:0004470)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.1	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis

Results for ZIC2_GLI1

Z-value: 0.59

Motif logo

Transcription factors associated with ZIC2_GLI1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the ZIC2_GLI1 motif across conditions

Conditions sorted by the z-value of the ZIC2_GLI1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC2_GLI1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: