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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZIC3_ZIC4

Z-value: 1.65

Motif logo

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Transcription factors associated with ZIC3_ZIC4

Gene Symbol Gene ID Gene Info
ENSG00000156925.7 ZIC3
ENSG00000174963.13 ZIC4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
ZIC3chrX_136649954_13665010513520.4406380.693.9e-02Click!
ZIC3chrX_136647497_1366476487290.5285020.684.5e-02Click!
ZIC3chrX_136649472_1366496238700.6018610.581.0e-01Click!
ZIC3chrX_136649682_13664990211150.5080720.561.2e-01Click!
ZIC3chrX_136648337_1366486021680.9454100.561.2e-01Click!
ZIC4chr3_147125253_1471254046810.6343370.206.1e-01Click!

Activity of the ZIC3_ZIC4 motif across conditions

Conditions sorted by the z-value of the ZIC3_ZIC4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr17_38600137_38600500 0.43 IGFBP4
insulin-like growth factor binding protein 4
605
0.66
chr11_73100197_73100477 0.43 RP11-809N8.2

7144
0.15
chr17_77904427_77904652 0.40 TBC1D16
TBC1 domain family, member 16
20088
0.18
chr4_44449502_44449653 0.39 KCTD8
potassium channel tetramerization domain containing 8
53
0.88
chr3_142840251_142840402 0.35 CHST2
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
2153
0.37
chr6_74161154_74161429 0.35 MB21D1
Mab-21 domain containing 1
691
0.49
chr5_135170958_135171109 0.34 SLC25A48
solute carrier family 25, member 48
617
0.7
chr8_22977343_22977524 0.33 TNFRSF10C
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
16999
0.13
chr5_1386620_1386888 0.33 SLC6A3
solute carrier family 6 (neurotransmitter transporter), member 3
14668
0.2
chr17_72594749_72594939 0.29 CD300LD
CD300 molecule-like family member d
6422
0.13
chr10_95315125_95315276 0.29 FFAR4
free fatty acid receptor 4
11222
0.16
chr20_11241961_11242112 0.29 C20orf187
chromosome 20 open reading frame 187
233225
0.02
chr1_212872826_212872977 0.29 BATF3
basic leucine zipper transcription factor, ATF-like 3
426
0.82
chr1_21503657_21503851 0.28 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
377
0.66
chr9_19551364_19551515 0.28 RP11-363E7.4

98232
0.07
chr17_35285280_35285503 0.28 RP11-445F12.1

8530
0.14
chr17_80176111_80176376 0.27 RP13-516M14.2

4140
0.12
chr9_74384006_74384157 0.27 TMEM2
transmembrane protein 2
281
0.95
chr7_582328_582615 0.27 ENSG00000252986
.
7899
0.18
chr1_154158713_154158864 0.26 TPM3
tropomyosin 3
3104
0.13
chr12_111079520_111079671 0.26 TCTN1
tectonic family member 1
741
0.59
chr17_14822625_14822776 0.26 ENSG00000238806
.
318500
0.01
chr14_76843614_76843766 0.26 ENSG00000263880
.
22338
0.18
chr20_30411382_30411533 0.26 MYLK2
myosin light chain kinase 2
4281
0.16
chr10_80886709_80887280 0.25 ZMIZ1
zinc finger, MIZ-type containing 1
58202
0.14
chr19_4279328_4279696 0.25 SHD
Src homology 2 domain containing transforming protein D
219
0.87
chr14_102002023_102002232 0.25 ENSG00000258498
.
24632
0.17
chr17_71586433_71586688 0.25 RP11-277J6.2

50605
0.13
chr7_45925213_45925504 0.25 IGFBP1
insulin-like growth factor binding protein 1
2598
0.25
chr18_77331216_77331367 0.25 AC018445.1
Uncharacterized protein
55234
0.15
chr15_70540546_70541057 0.25 ENSG00000200216
.
55226
0.16
chr8_62722273_62722424 0.25 ENSG00000264408
.
95001
0.08
chr6_6728512_6728665 0.24 LY86-AS1
LY86 antisense RNA 1
105584
0.07
chr17_74025598_74025749 0.24 EVPL
envoplakin
2140
0.19
chr10_65224937_65225088 0.24 JMJD1C-AS1
JMJD1C antisense RNA 1
23
0.93
chr17_37914792_37914943 0.24 GRB7
growth factor receptor-bound protein 7
16362
0.11
chr12_124875119_124875344 0.24 NCOR2
nuclear receptor corepressor 2
1861
0.47
chr4_122617648_122617799 0.24 ANXA5
annexin A5
394
0.89
chr17_74377867_74378161 0.24 SPHK1
sphingosine kinase 1
162
0.92
chr2_109605860_109606011 0.23 EDAR
ectodysplasin A receptor
107
0.98
chr2_66673650_66673801 0.23 MEIS1
Meis homeobox 1
3628
0.19
chr17_79480328_79480479 0.23 ACTG1
actin, gamma 1
503
0.46
chr15_90625478_90625629 0.23 RP11-617F23.1

114
0.95
chr16_17317009_17317184 0.23 CTD-2576D5.4

88735
0.1
chr16_57831186_57831470 0.23 KIFC3
kinesin family member C3
348
0.84
chr17_55860787_55861007 0.23 ENSG00000222976
.
5913
0.21
chr13_33412405_33412556 0.23 ENSG00000207325
.
74790
0.11
chr20_60941090_60941476 0.23 LAMA5
laminin, alpha 5
1043
0.39
chr5_171998769_171998920 0.22 AC027309.1

37592
0.15
chr16_87871055_87871206 0.22 RP4-536B24.2

992
0.54
chr1_204959299_204959565 0.22 NFASC
neurofascin
1640
0.4
chr3_159579244_159579395 0.22 SCHIP1
schwannomin interacting protein 1
8591
0.21
chr14_65435464_65435615 0.22 RAB15
RAB15, member RAS oncogene family
3073
0.16
chr2_122014973_122015141 0.22 TFCP2L1
transcription factor CP2-like 1
27726
0.25
chr5_149867423_149867730 0.22 NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
1719
0.35
chr8_53043724_53043875 0.22 RP11-26M5.3

19581
0.24
chr14_69122374_69122525 0.22 CTD-2325P2.4

27287
0.18
chr6_74432173_74432346 0.22 RP11-553A21.3

26405
0.17
chr22_43506432_43506584 0.21 BIK
BCL2-interacting killer (apoptosis-inducing)
246
0.9
chr5_139487909_139488137 0.21 LINC01024
long intergenic non-protein coding RNA 1024
127
0.95
chr14_96342982_96343133 0.21 ENSG00000263357
.
25130
0.23
chr1_10519294_10519577 0.21 RP5-1113E3.3

823
0.46
chr15_74325155_74325331 0.21 PML
promyelocytic leukemia
8022
0.16
chr21_30688780_30689338 0.21 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
10391
0.18
chr11_65780370_65780606 0.21 CST6
cystatin E/M
1176
0.27
chr9_38672362_38672574 0.20 ENSG00000252725
.
7535
0.24
chr2_8821447_8821664 0.20 AC011747.7

438
0.57
chr6_38607899_38608192 0.20 BTBD9
BTB (POZ) domain containing 9
121
0.97
chr3_17944629_17944780 0.20 TBC1D5
TBC1 domain family, member 5
160560
0.04
chr11_126216427_126216820 0.20 ST3GAL4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
8932
0.14
chr3_134624316_134624467 0.20 EPHB1
EPH receptor B1
53043
0.16
chr5_1005247_1005480 0.20 ENSG00000221244
.
1061
0.41
chr7_41852060_41852211 0.20 AC005027.3

107202
0.07
chr1_114657022_114657208 0.20 SYT6
synaptotagmin VI
37947
0.19
chr1_2158798_2158949 0.20 SKI
v-ski avian sarcoma viral oncogene homolog
1261
0.34
chrX_53349853_53350130 0.20 IQSEC2
IQ motif and Sec7 domain 2
531
0.75
chr16_58497854_58498037 0.20 NDRG4
NDRG family member 4
17
0.97
chr11_68530734_68530885 0.20 MTL5
metallothionein-like 5, testis-specific (tesmin)
11777
0.2
chr22_27524680_27524831 0.20 ENSG00000200443
.
92905
0.1
chr13_110381697_110381924 0.20 LINC00676
long intergenic non-protein coding RNA 676
1181
0.62
chr12_52407645_52407796 0.20 GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
2753
0.18
chr22_48972497_48972648 0.19 FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
454
0.88
chr2_203025624_203025775 0.19 AC079354.5

18415
0.15
chr10_30748355_30748506 0.19 MAP3K8
mitogen-activated protein kinase kinase kinase 8
20679
0.21
chr2_44058741_44059019 0.19 ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
7009
0.18
chr1_10746935_10747086 0.19 CASZ1
castor zinc finger 1
41877
0.14
chr22_19710642_19710976 0.19 GP1BB
glycoprotein Ib (platelet), beta polypeptide
341
0.86
chr5_136827472_136827623 0.19 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
6700
0.27
chr14_68556146_68556297 0.19 CTD-2566J3.1

40692
0.18
chr15_31685781_31685934 0.19 KLF13
Kruppel-like factor 13
27500
0.25
chr16_2198362_2198540 0.19 RAB26
RAB26, member RAS oncogene family
174
0.83
chr1_154378255_154378406 0.19 IL6R
interleukin 6 receptor
239
0.79
chr9_1051829_1051980 0.19 DMRT2
doublesex and mab-3 related transcription factor 2
290
0.93
chr19_13202769_13202920 0.19 LYL1
lymphoblastic leukemia derived sequence 1
10837
0.1
chr13_112547435_112547586 0.19 ENSG00000264989
.
15638
0.29
chr7_23736830_23737011 0.18 STK31
serine/threonine kinase 31
12866
0.16
chr4_7972689_7972840 0.18 AFAP1
actin filament associated protein 1
31111
0.14
chr16_89188310_89188461 0.18 CTD-2555A7.3

6698
0.16
chr10_121080665_121080816 0.18 RP11-79M19.2

14954
0.2
chr1_54153130_54153281 0.18 ENSG00000239007
.
1280
0.5
chr5_22853160_22853311 0.18 CDH12
cadherin 12, type 2 (N-cadherin 2)
215
0.97
chr1_228352022_228352173 0.18 IBA57-AS1
IBA57 antisense RNA 1 (head to head)
1116
0.29
chr15_91458200_91458390 0.18 MAN2A2
mannosidase, alpha, class 2A, member 2
2177
0.15
chr6_157882968_157883119 0.18 ENSG00000266617
.
67121
0.12
chr1_204776345_204776581 0.18 NFASC
neurofascin
21319
0.2
chr17_48350379_48350530 0.18 TMEM92
transmembrane protein 92
1334
0.33
chr18_46065806_46065983 0.18 CTIF
CBP80/20-dependent translation initiation factor
108
0.98
chr17_80291269_80291420 0.18 SECTM1
secreted and transmembrane 1
294
0.83
chr16_644060_644236 0.18 RAB40C
RAB40C, member RAS oncogene family
3816
0.09
chr9_139716096_139716247 0.18 RABL6
RAB, member RAS oncogene family-like 6
390
0.64
chr11_20134359_20134761 0.18 NAV2-AS1
NAV2 antisense RNA 1
7618
0.23
chr4_174139787_174140018 0.18 RP11-10K16.1

49099
0.11
chr2_100171123_100171274 0.18 AFF3
AF4/FMR2 family, member 3
23634
0.19
chr20_734961_735112 0.18 SLC52A3
solute carrier family 52 (riboflavin transporter), member 3
14095
0.2
chrX_46570531_46570682 0.18 SLC9A7
solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
47884
0.16
chr1_154763833_154763984 0.18 KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
68411
0.08
chr7_150020672_150020823 0.18 ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
11
0.84
chr10_47749182_47749333 0.18 ANXA8L2
annexin A8-like 2
2221
0.25
chrX_152912384_152912535 0.18 DUSP9
dual specificity phosphatase 9
191
0.91
chr17_2626915_2627066 0.18 CLUH
clustered mitochondria (cluA/CLU1) homolog
11033
0.11
chr16_3006567_3006722 0.18 LA16c-321D4.2

2367
0.12
chr3_148184411_148184664 0.18 AGTR1
angiotensin II receptor, type 1
231034
0.02
chr5_139125701_139125887 0.18 ENSG00000200756
.
28119
0.17
chr5_11384831_11385016 0.18 CTNND2
catenin (cadherin-associated protein), delta 2
204000
0.03
chr16_50597873_50598024 0.18 RP11-401P9.1

10097
0.17
chr22_27812652_27812803 0.17 RP11-375H17.1

299741
0.01
chr11_119554728_119554879 0.17 ENSG00000199217
.
27782
0.16
chr16_55512713_55512866 0.17 MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
47
0.98
chr2_220435040_220435191 0.17 OBSL1
obscurin-like 1
848
0.34
chr8_20898687_20898838 0.17 ENSG00000215945
.
114880
0.07
chr5_139063267_139063418 0.17 CXXC5
CXXC finger protein 5
4074
0.25
chr3_133392987_133393138 0.17 ENSG00000252641
.
9283
0.15
chr5_148645320_148645471 0.17 AFAP1L1
actin filament associated protein 1-like 1
6039
0.14
chr19_55884009_55884160 0.17 IL11
interleukin 11
2253
0.11
chr17_68674046_68674197 0.17 KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
508445
0.0
chr21_16236639_16236939 0.17 AF127577.8

54066
0.15
chr19_39636014_39636168 0.17 CTC-218B8.3

8988
0.13
chr17_47645178_47645393 0.17 RP5-1029K10.2

6141
0.13
chr13_22243741_22243916 0.17 FGF9
fibroblast growth factor 9
1694
0.46
chr21_39812982_39813157 0.17 ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
57276
0.16
chr8_97506971_97507442 0.17 SDC2
syndecan 2
970
0.67
chr2_46770771_46771016 0.17 RHOQ
ras homolog family member Q
354
0.78
chr12_125139086_125139237 0.17 NCOR2
nuclear receptor corepressor 2
87151
0.1
chr2_114100712_114100863 0.17 IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
63186
0.08
chr8_123378321_123378472 0.16 ENSG00000238901
.
305134
0.01
chr6_158989738_158990048 0.16 TMEM181
transmembrane protein 181
32425
0.16
chr17_47516412_47516563 0.16 ENSG00000207127
.
22275
0.12
chr1_220498823_220498974 0.16 RAB3GAP2
RAB3 GTPase activating protein subunit 2 (non-catalytic)
53102
0.14
chr15_98447614_98447765 0.16 ARRDC4
arrestin domain containing 4
15095
0.2
chr20_24763571_24763722 0.16 CST7
cystatin F (leukocystatin)
166220
0.03
chr21_32656703_32656854 0.16 TIAM1
T-cell lymphoma invasion and metastasis 1
7695
0.31
chr8_41649260_41649615 0.16 ANK1
ankyrin 1, erythrocytic
5703
0.2
chr22_25871447_25871598 0.16 CTA-390C10.10

663
0.67
chr11_117812434_117812585 0.16 TMPRSS13
transmembrane protease, serine 13
12335
0.17
chr14_105444909_105445181 0.16 AHNAK2
AHNAK nucleoprotein 2
351
0.85
chr11_67168630_67168781 0.16 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
554
0.49
chr10_13701534_13702115 0.16 RP11-295P9.12

15822
0.13
chr6_164518955_164519106 0.16 ENSG00000266128
.
257437
0.02
chr10_22764575_22765032 0.16 RP11-301N24.3

114702
0.06
chr10_88852872_88853023 0.16 GLUD1
glutamate dehydrogenase 1
880
0.36
chr12_25017223_25017374 0.16 RP11-625L16.3

33943
0.15
chr11_2934551_2934724 0.16 SLC22A18AS
solute carrier family 22 (organic cation transporter), member 18 antisense
9667
0.12
chr4_78980714_78980865 0.16 FRAS1
Fraser syndrome 1
2065
0.46
chr12_124871142_124871293 0.16 NCOR2
nuclear receptor corepressor 2
2153
0.43
chr8_77493485_77493672 0.16 RP11-115I9.1

1998
0.42
chr16_4579167_4579381 0.16 CDIP1
cell death-inducing p53 target 1
6748
0.13
chrX_64254927_64255105 0.16 ZC4H2
zinc finger, C4H2 domain containing
423
0.92
chr7_76980949_76981220 0.16 GSAP
gamma-secretase activating protein
21400
0.22
chr16_87379117_87379268 0.16 RP11-178L8.4

11313
0.1
chr4_151000496_151000693 0.16 DCLK2
doublecortin-like kinase 2
414
0.91
chr3_59503009_59503160 0.16 NPCDR1
nasopharyngeal carcinoma, down-regulated 1
454499
0.01
chr12_3358339_3358521 0.16 TSPAN9
tetraspanin 9
48089
0.16
chr5_131543629_131543780 0.16 P4HA2
prolyl 4-hydroxylase, alpha polypeptide II
14080
0.16
chr17_38600560_38600819 0.16 IGFBP4
insulin-like growth factor binding protein 4
976
0.46
chr8_144960232_144960383 0.16 EPPK1
epiplakin 1
7675
0.11
chr2_23608807_23609156 0.16 KLHL29
kelch-like family member 29
893
0.74
chr16_31488502_31488862 0.16 TGFB1I1
transforming growth factor beta 1 induced transcript 1
3935
0.1
chr1_86968635_86969118 0.16 CLCA1
chloride channel accessory 1
34350
0.16
chr17_42154780_42155022 0.16 G6PC3
glucose 6 phosphatase, catalytic, 3
2799
0.14
chr4_113174579_113174763 0.15 AP1AR
adaptor-related protein complex 1 associated regulatory protein
11537
0.15
chr11_61515322_61515473 0.15 MYRF
myelin regulatory factor
4724
0.15
chr19_1907709_1907860 0.15 ADAT3
adenosine deaminase, tRNA-specific 3
234
0.68
chrX_9801102_9801516 0.15 ENSG00000206844
.
41432
0.15
chr12_66232016_66232167 0.15 HMGA2
high mobility group AT-hook 2
13188
0.19
chr16_88827167_88827318 0.15 RP5-1142A6.8

18013
0.07
chr19_54386339_54386490 0.15 PRKCG
protein kinase C, gamma
499
0.56
chr2_99552364_99552545 0.15 KIAA1211L
KIAA1211-like
212
0.96
chr8_123874992_123875143 0.15 ZHX2
zinc fingers and homeoboxes 2
557
0.78
chr11_45672012_45672287 0.15 RP11-495O11.1

930
0.62
chr19_9879532_9879683 0.15 ZNF846
zinc finger protein 846
197
0.9
chr12_194668_194819 0.15 IQSEC3
IQ motif and Sec7 domain 3
8201
0.17
chr16_765719_765951 0.15 METRN
meteorin, glial cell differentiation regulator
194
0.8
chr2_127826599_127826750 0.15 BIN1
bridging integrator 1
37903
0.18
chr8_97825590_97825741 0.15 CPQ
carboxypeptidase Q
52197
0.18
chr1_85527575_85527769 0.15 WDR63
WD repeat domain 63
323
0.89
chr1_42046509_42046707 0.15 RP11-486B10.3

45494
0.16
chr2_45162375_45162583 0.15 SIX3-AS1
SIX3 antisense RNA 1
6154
0.24
chr19_17641532_17641686 0.15 FAM129C
family with sequence similarity 129, member C
3496
0.13
chr2_105090262_105090413 0.15 ENSG00000199727
.
58894
0.15
chr7_151145465_151145709 0.15 CRYGN
crystallin, gamma N
8457
0.12

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of ZIC3_ZIC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.1 0.2 GO:0003079 obsolete positive regulation of natriuresis(GO:0003079)
0.1 0.2 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1 0.3 GO:0045217 cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0 0.2 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.1 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.2 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0 0.1 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.2 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.0 0.2 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0072179 nephric duct formation(GO:0072179)
0.0 0.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.2 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:1903077 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.1 GO:0060457 negative regulation of digestive system process(GO:0060457)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0032819 positive regulation of natural killer cell proliferation(GO:0032819)
0.0 0.1 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0 0.0 GO:0032462 regulation of protein homooligomerization(GO:0032462)
0.0 0.1 GO:0021932 hindbrain radial glia guided cell migration(GO:0021932)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.1 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.0 0.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0045007 depurination(GO:0045007)
0.0 0.1 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.0 0.1 GO:0000089 mitotic metaphase(GO:0000089)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway(GO:0033145)
0.0 0.1 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.1 GO:0051014 actin filament severing(GO:0051014)
0.0 0.0 GO:0032730 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0 0.2 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.0 0.1 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.1 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.1 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.0 0.1 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.0 GO:0070572 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.0 GO:0032347 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.1 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.1 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.0 0.0 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.1 GO:0060438 trachea development(GO:0060438)
0.0 0.0 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.1 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.0 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.0 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.1 GO:0002911 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.0 0.0 GO:0032928 regulation of superoxide anion generation(GO:0032928)
0.0 0.0 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.0 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.0 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.0 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.0 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.0 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 0.0 GO:0032328 alanine transport(GO:0032328)
0.0 0.0 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.0 GO:0034201 response to oleic acid(GO:0034201)
0.0 0.1 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.2 GO:0007530 sex determination(GO:0007530)
0.0 0.1 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.0 GO:0060014 granulosa cell differentiation(GO:0060014)
0.0 0.0 GO:1901534 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.0 GO:0003181 atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0 0.1 GO:0031622 regulation of fever generation(GO:0031620) positive regulation of fever generation(GO:0031622)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.1 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.0 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.0 GO:0044254 multicellular organismal protein catabolic process(GO:0044254) protein digestion(GO:0044256) multicellular organismal macromolecule catabolic process(GO:0044266) multicellular organismal protein metabolic process(GO:0044268)
0.0 0.1 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.0 0.0 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.0 GO:0034723 DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.0 GO:0060413 atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0 0.2 GO:0007128 meiotic prophase I(GO:0007128)
0.0 0.0 GO:0042268 regulation of cytolysis(GO:0042268)
0.0 0.0 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.0 GO:0090009 primitive streak formation(GO:0090009)
0.0 0.0 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.1 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.0 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.0 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.0 GO:0008054 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0 0.1 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.1 GO:0005984 disaccharide metabolic process(GO:0005984)
0.0 0.1 GO:0007549 dosage compensation(GO:0007549)
0.0 0.1 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.1 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 0.0 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.0 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.1 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.1 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.3 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0042597 outer membrane-bounded periplasmic space(GO:0030288) periplasmic space(GO:0042597)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.5 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.0 GO:0001740 Barr body(GO:0001740)
0.0 0.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.0 GO:0017059 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.0 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0031312 extrinsic component of organelle membrane(GO:0031312)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.2 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.2 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.2 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.1 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0001228 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.3 GO:0043499 obsolete eukaryotic cell surface binding(GO:0043499)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.0 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.0 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.0 GO:0002060 purine nucleobase binding(GO:0002060)
0.0 0.1 GO:0005497 androgen binding(GO:0005497)
0.0 0.0 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.0 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.0 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.0 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.0 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.0 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.0 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.0 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.0 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.0 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.0 0.1 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.0 0.0 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.0 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.0 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.0 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0004954 prostanoid receptor activity(GO:0004954)
0.0 0.0 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.0 0.0 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.1 GO:0005112 Notch binding(GO:0005112)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.1 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.1 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.1 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.1 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.1 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.0 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.1 REACTOME POL SWITCHING Genes involved in Polymerase switching