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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for ZIC3_ZIC4

Z-value: 1.65

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Transcription factors associated with ZIC3_ZIC4

Gene Symbol Gene ID Gene Info
ZIC3
ENSG00000156925.7 Zic family member 3
ZIC4
ENSG00000174963.13 Zic family member 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chrX_136649954_136650105ZIC313520.4406380.693.9e-02Click!
chrX_136647497_136647648ZIC37290.5285020.684.5e-02Click!
chrX_136649472_136649623ZIC38700.6018610.581.0e-01Click!
chrX_136649682_136649902ZIC311150.5080720.561.2e-01Click!
chrX_136648337_136648602ZIC31680.9454100.561.2e-01Click!
chr3_147125253_147125404ZIC46810.6343370.206.1e-01Click!

Activity of the ZIC3_ZIC4 motif across conditions

Conditions sorted by the z-value of the ZIC3_ZIC4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr17_38600137_38600500 0.43 IGFBP4
 insulin-like growth factor binding protein 4
 605
 0.66
chr11_73100197_73100477 0.43 RP11-809N8.2
7144
 0.15
chr17_77904427_77904652 0.40 TBC1D16
 TBC1 domain family, member 16
 20088
 0.18
chr4_44449502_44449653 0.39 KCTD8
 potassium channel tetramerization domain containing 8
 53
 0.88
chr3_142840251_142840402 0.35 CHST2
 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
 2153
 0.37
chr6_74161154_74161429 0.35 MB21D1
 Mab-21 domain containing 1
 691
 0.49
chr5_135170958_135171109 0.34 SLC25A48
 solute carrier family 25, member 48
 617
 0.7
chr8_22977343_22977524 0.33 TNFRSF10C
 tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
 16999
 0.13
chr5_1386620_1386888 0.33 SLC6A3
 solute carrier family 6 (neurotransmitter transporter), member 3
 14668
 0.2
chr17_72594749_72594939 0.29 CD300LD
 CD300 molecule-like family member d
 6422
 0.13
chr10_95315125_95315276 0.29 FFAR4
 free fatty acid receptor 4
 11222
 0.16
chr20_11241961_11242112 0.29 C20orf187
 chromosome 20 open reading frame 187
 233225
 0.02
chr1_212872826_212872977 0.29 BATF3
 basic leucine zipper transcription factor, ATF-like 3
 426
 0.82
chr1_21503657_21503851 0.28 EIF4G3
 eukaryotic translation initiation factor 4 gamma, 3
 377
 0.66
chr9_19551364_19551515 0.28 RP11-363E7.4
98232
 0.07
chr17_35285280_35285503 0.28 RP11-445F12.1
8530
 0.14
chr17_80176111_80176376 0.27 RP13-516M14.2
4140
 0.12
chr9_74384006_74384157 0.27 TMEM2
 transmembrane protein 2
 281
 0.95
chr7_582328_582615 0.27 ENSG00000252986
 .
 7899
 0.18
chr1_154158713_154158864 0.26 TPM3
 tropomyosin 3
 3104
 0.13
chr12_111079520_111079671 0.26 TCTN1
 tectonic family member 1
 741
 0.59
chr17_14822625_14822776 0.26 ENSG00000238806
 .
 318500
 0.01
chr14_76843614_76843766 0.26 ENSG00000263880
 .
 22338
 0.18
chr20_30411382_30411533 0.26 MYLK2
 myosin light chain kinase 2
 4281
 0.16
chr10_80886709_80887280 0.25 ZMIZ1
 zinc finger, MIZ-type containing 1
 58202
 0.14
chr19_4279328_4279696 0.25 SHD
 Src homology 2 domain containing transforming protein D
 219
 0.87
chr14_102002023_102002232 0.25 ENSG00000258498
 .
 24632
 0.17
chr17_71586433_71586688 0.25 RP11-277J6.2
50605
 0.13
chr7_45925213_45925504 0.25 IGFBP1
 insulin-like growth factor binding protein 1
 2598
 0.25
chr18_77331216_77331367 0.25 AC018445.1
 Uncharacterized protein
 55234
 0.15
chr15_70540546_70541057 0.25 ENSG00000200216
 .
 55226
 0.16
chr8_62722273_62722424 0.25 ENSG00000264408
 .
 95001
 0.08
chr6_6728512_6728665 0.24 LY86-AS1
 LY86 antisense RNA 1
 105584
 0.07
chr17_74025598_74025749 0.24 EVPL
 envoplakin
 2140
 0.19
chr10_65224937_65225088 0.24 JMJD1C-AS1
 JMJD1C antisense RNA 1
 23
 0.93
chr17_37914792_37914943 0.24 GRB7
 growth factor receptor-bound protein 7
 16362
 0.11
chr12_124875119_124875344 0.24 NCOR2
 nuclear receptor corepressor 2
 1861
 0.47
chr4_122617648_122617799 0.24 ANXA5
 annexin A5
 394
 0.89
chr17_74377867_74378161 0.24 SPHK1
 sphingosine kinase 1
 162
 0.92
chr2_109605860_109606011 0.23 EDAR
 ectodysplasin A receptor
 107
 0.98
chr2_66673650_66673801 0.23 MEIS1
 Meis homeobox 1
 3628
 0.19
chr17_79480328_79480479 0.23 ACTG1
 actin, gamma 1
 503
 0.46
chr15_90625478_90625629 0.23 RP11-617F23.1
114
 0.95
chr16_17317009_17317184 0.23 CTD-2576D5.4
88735
 0.1
chr16_57831186_57831470 0.23 KIFC3
 kinesin family member C3
 348
 0.84
chr17_55860787_55861007 0.23 ENSG00000222976
 .
 5913
 0.21
chr13_33412405_33412556 0.23 ENSG00000207325
 .
 74790
 0.11
chr20_60941090_60941476 0.23 LAMA5
 laminin, alpha 5
 1043
 0.39
chr5_171998769_171998920 0.22 AC027309.1
37592
 0.15
chr16_87871055_87871206 0.22 RP4-536B24.2
992
 0.54
chr1_204959299_204959565 0.22 NFASC
 neurofascin
 1640
 0.4
chr3_159579244_159579395 0.22 SCHIP1
 schwannomin interacting protein 1
 8591
 0.21
chr14_65435464_65435615 0.22 RAB15
 RAB15, member RAS oncogene family
 3073
 0.16
chr2_122014973_122015141 0.22 TFCP2L1
 transcription factor CP2-like 1
 27726
 0.25
chr5_149867423_149867730 0.22 NDST1
 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
 1719
 0.35
chr8_53043724_53043875 0.22 RP11-26M5.3
19581
 0.24
chr14_69122374_69122525 0.22 CTD-2325P2.4
27287
 0.18
chr6_74432173_74432346 0.22 RP11-553A21.3
26405
 0.17
chr22_43506432_43506584 0.21 BIK
 BCL2-interacting killer (apoptosis-inducing)
 246
 0.9
chr5_139487909_139488137 0.21 LINC01024
 long intergenic non-protein coding RNA 1024
 127
 0.95
chr14_96342982_96343133 0.21 ENSG00000263357
 .
 25130
 0.23
chr1_10519294_10519577 0.21 RP5-1113E3.3
823
 0.46
chr15_74325155_74325331 0.21 PML
 promyelocytic leukemia
 8022
 0.16
chr21_30688780_30689338 0.21 BACH1
 BTB and CNC homology 1, basic leucine zipper transcription factor 1
 10391
 0.18
chr11_65780370_65780606 0.21 CST6
 cystatin E/M
 1176
 0.27
chr9_38672362_38672574 0.20 ENSG00000252725
 .
 7535
 0.24
chr2_8821447_8821664 0.20 AC011747.7
438
 0.57
chr6_38607899_38608192 0.20 BTBD9
 BTB (POZ) domain containing 9
 121
 0.97
chr3_17944629_17944780 0.20 TBC1D5
 TBC1 domain family, member 5
 160560
 0.04
chr11_126216427_126216820 0.20 ST3GAL4
 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
 8932
 0.14
chr3_134624316_134624467 0.20 EPHB1
 EPH receptor B1
 53043
 0.16
chr5_1005247_1005480 0.20 ENSG00000221244
 .
 1061
 0.41
chr7_41852060_41852211 0.20 AC005027.3
107202
 0.07
chr1_114657022_114657208 0.20 SYT6
 synaptotagmin VI
 37947
 0.19
chr1_2158798_2158949 0.20 SKI
 v-ski avian sarcoma viral oncogene homolog
 1261
 0.34
chrX_53349853_53350130 0.20 IQSEC2
 IQ motif and Sec7 domain 2
 531
 0.75
chr16_58497854_58498037 0.20 NDRG4
 NDRG family member 4
 17
 0.97
chr11_68530734_68530885 0.20 MTL5
 metallothionein-like 5, testis-specific (tesmin)
 11777
 0.2
chr22_27524680_27524831 0.20 ENSG00000200443
 .
 92905
 0.1
chr13_110381697_110381924 0.20 LINC00676
 long intergenic non-protein coding RNA 676
 1181
 0.62
chr12_52407645_52407796 0.20 GRASP
 GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
 2753
 0.18
chr22_48972497_48972648 0.19 FAM19A5
 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
 454
 0.88
chr2_203025624_203025775 0.19 AC079354.5
18415
 0.15
chr10_30748355_30748506 0.19 MAP3K8
 mitogen-activated protein kinase kinase kinase 8
 20679
 0.21
chr2_44058741_44059019 0.19 ABCG5
 ATP-binding cassette, sub-family G (WHITE), member 5
 7009
 0.18
chr1_10746935_10747086 0.19 CASZ1
 castor zinc finger 1
 41877
 0.14
chr22_19710642_19710976 0.19 GP1BB
 glycoprotein Ib (platelet), beta polypeptide
 341
 0.86
chr5_136827472_136827623 0.19 SPOCK1
 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
 6700
 0.27
chr14_68556146_68556297 0.19 CTD-2566J3.1
40692
 0.18
chr15_31685781_31685934 0.19 KLF13
 Kruppel-like factor 13
 27500
 0.25
chr16_2198362_2198540 0.19 RAB26
 RAB26, member RAS oncogene family
 174
 0.83
chr1_154378255_154378406 0.19 IL6R
 interleukin 6 receptor
 239
 0.79
chr9_1051829_1051980 0.19 DMRT2
 doublesex and mab-3 related transcription factor 2
 290
 0.93
chr19_13202769_13202920 0.19 LYL1
 lymphoblastic leukemia derived sequence 1
 10837
 0.1
chr13_112547435_112547586 0.19 ENSG00000264989
 .
 15638
 0.29
chr7_23736830_23737011 0.18 STK31
 serine/threonine kinase 31
 12866
 0.16
chr4_7972689_7972840 0.18 AFAP1
 actin filament associated protein 1
 31111
 0.14
chr16_89188310_89188461 0.18 CTD-2555A7.3
6698
 0.16
chr10_121080665_121080816 0.18 RP11-79M19.2
14954
 0.2
chr1_54153130_54153281 0.18 ENSG00000239007
 .
 1280
 0.5
chr5_22853160_22853311 0.18 CDH12
 cadherin 12, type 2 (N-cadherin 2)
 215
 0.97
chr1_228352022_228352173 0.18 IBA57-AS1
 IBA57 antisense RNA 1 (head to head)
 1116
 0.29
chr15_91458200_91458390 0.18 MAN2A2
 mannosidase, alpha, class 2A, member 2
 2177
 0.15
chr6_157882968_157883119 0.18 ENSG00000266617
 .
 67121
 0.12
chr1_204776345_204776581 0.18 NFASC
 neurofascin
 21319
 0.2
chr17_48350379_48350530 0.18 TMEM92
 transmembrane protein 92
 1334
 0.33
chr18_46065806_46065983 0.18 CTIF
 CBP80/20-dependent translation initiation factor
 108
 0.98
chr17_80291269_80291420 0.18 SECTM1
 secreted and transmembrane 1
 294
 0.83
chr16_644060_644236 0.18 RAB40C
 RAB40C, member RAS oncogene family
 3816
 0.09
chr9_139716096_139716247 0.18 RABL6
 RAB, member RAS oncogene family-like 6
 390
 0.64
chr11_20134359_20134761 0.18 NAV2-AS1
 NAV2 antisense RNA 1
 7618
 0.23
chr4_174139787_174140018 0.18 RP11-10K16.1
49099
 0.11
chr2_100171123_100171274 0.18 AFF3
 AF4/FMR2 family, member 3
 23634
 0.19
chr20_734961_735112 0.18 SLC52A3
 solute carrier family 52 (riboflavin transporter), member 3
 14095
 0.2
chrX_46570531_46570682 0.18 SLC9A7
 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
 47884
 0.16
chr1_154763833_154763984 0.18 KCNN3
 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
 68411
 0.08
chr7_150020672_150020823 0.18 ACTR3C
 ARP3 actin-related protein 3 homolog C (yeast)
 11
 0.84
chr10_47749182_47749333 0.18 ANXA8L2
 annexin A8-like 2
 2221
 0.25
chrX_152912384_152912535 0.18 DUSP9
 dual specificity phosphatase 9
 191
 0.91
chr17_2626915_2627066 0.18 CLUH
 clustered mitochondria (cluA/CLU1) homolog
 11033
 0.11
chr16_3006567_3006722 0.18 LA16c-321D4.2
2367
 0.12
chr3_148184411_148184664 0.18 AGTR1
 angiotensin II receptor, type 1
 231034
 0.02
chr5_139125701_139125887 0.18 ENSG00000200756
 .
 28119
 0.17
chr5_11384831_11385016 0.18 CTNND2
 catenin (cadherin-associated protein), delta 2
 204000
 0.03
chr16_50597873_50598024 0.18 RP11-401P9.1
10097
 0.17
chr22_27812652_27812803 0.17 RP11-375H17.1
299741
 0.01
chr11_119554728_119554879 0.17 ENSG00000199217
 .
 27782
 0.16
chr16_55512713_55512866 0.17 MMP2
 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
 47
 0.98
chr2_220435040_220435191 0.17 OBSL1
 obscurin-like 1
 848
 0.34
chr8_20898687_20898838 0.17 ENSG00000215945
 .
 114880
 0.07
chr5_139063267_139063418 0.17 CXXC5
 CXXC finger protein 5
 4074
 0.25
chr3_133392987_133393138 0.17 ENSG00000252641
 .
 9283
 0.15
chr5_148645320_148645471 0.17 AFAP1L1
 actin filament associated protein 1-like 1
 6039
 0.14
chr19_55884009_55884160 0.17 IL11
 interleukin 11
 2253
 0.11
chr17_68674046_68674197 0.17 KCNJ2
 potassium inwardly-rectifying channel, subfamily J, member 2
 508445
 0.0
chr21_16236639_16236939 0.17 AF127577.8
54066
 0.15
chr19_39636014_39636168 0.17 CTC-218B8.3
8988
 0.13
chr17_47645178_47645393 0.17 RP5-1029K10.2
6141
 0.13
chr13_22243741_22243916 0.17 FGF9
 fibroblast growth factor 9
 1694
 0.46
chr21_39812982_39813157 0.17 ERG
 v-ets avian erythroblastosis virus E26 oncogene homolog
 57276
 0.16
chr8_97506971_97507442 0.17 SDC2
 syndecan 2
 970
 0.67
chr2_46770771_46771016 0.17 RHOQ
 ras homolog family member Q
 354
 0.78
chr12_125139086_125139237 0.17 NCOR2
 nuclear receptor corepressor 2
 87151
 0.1
chr2_114100712_114100863 0.17 IGKV1OR2-108
 immunoglobulin kappa variable 1/OR2-108 (non-functional)
 63186
 0.08
chr8_123378321_123378472 0.16 ENSG00000238901
 .
 305134
 0.01
chr6_158989738_158990048 0.16 TMEM181
 transmembrane protein 181
 32425
 0.16
chr17_47516412_47516563 0.16 ENSG00000207127
 .
 22275
 0.12
chr1_220498823_220498974 0.16 RAB3GAP2
 RAB3 GTPase activating protein subunit 2 (non-catalytic)
 53102
 0.14
chr15_98447614_98447765 0.16 ARRDC4
 arrestin domain containing 4
 15095
 0.2
chr20_24763571_24763722 0.16 CST7
 cystatin F (leukocystatin)
 166220
 0.03
chr21_32656703_32656854 0.16 TIAM1
 T-cell lymphoma invasion and metastasis 1
 7695
 0.31
chr8_41649260_41649615 0.16 ANK1
 ankyrin 1, erythrocytic
 5703
 0.2
chr22_25871447_25871598 0.16 CTA-390C10.10
663
 0.67
chr11_117812434_117812585 0.16 TMPRSS13
 transmembrane protease, serine 13
 12335
 0.17
chr14_105444909_105445181 0.16 AHNAK2
 AHNAK nucleoprotein 2
 351
 0.85
chr11_67168630_67168781 0.16 PPP1CA
 protein phosphatase 1, catalytic subunit, alpha isozyme
 554
 0.49
chr10_13701534_13702115 0.16 RP11-295P9.12
15822
 0.13
chr6_164518955_164519106 0.16 ENSG00000266128
 .
 257437
 0.02
chr10_22764575_22765032 0.16 RP11-301N24.3
114702
 0.06
chr10_88852872_88853023 0.16 GLUD1
 glutamate dehydrogenase 1
 880
 0.36
chr12_25017223_25017374 0.16 RP11-625L16.3
33943
 0.15
chr11_2934551_2934724 0.16 SLC22A18AS
 solute carrier family 22 (organic cation transporter), member 18 antisense
 9667
 0.12
chr4_78980714_78980865 0.16 FRAS1
 Fraser syndrome 1
 2065
 0.46
chr12_124871142_124871293 0.16 NCOR2
 nuclear receptor corepressor 2
 2153
 0.43
chr8_77493485_77493672 0.16 RP11-115I9.1
1998
 0.42
chr16_4579167_4579381 0.16 CDIP1
 cell death-inducing p53 target 1
 6748
 0.13
chrX_64254927_64255105 0.16 ZC4H2
 zinc finger, C4H2 domain containing
 423
 0.92
chr7_76980949_76981220 0.16 GSAP
 gamma-secretase activating protein
 21400
 0.22
chr16_87379117_87379268 0.16 RP11-178L8.4
11313
 0.1
chr4_151000496_151000693 0.16 DCLK2
 doublecortin-like kinase 2
 414
 0.91
chr3_59503009_59503160 0.16 NPCDR1
 nasopharyngeal carcinoma, down-regulated 1
 454499
 0.01
chr12_3358339_3358521 0.16 TSPAN9
 tetraspanin 9
 48089
 0.16
chr5_131543629_131543780 0.16 P4HA2
 prolyl 4-hydroxylase, alpha polypeptide II
 14080
 0.16
chr17_38600560_38600819 0.16 IGFBP4
 insulin-like growth factor binding protein 4
 976
 0.46
chr8_144960232_144960383 0.16 EPPK1
 epiplakin 1
 7675
 0.11
chr2_23608807_23609156 0.16 KLHL29
 kelch-like family member 29
 893
 0.74
chr16_31488502_31488862 0.16 TGFB1I1
 transforming growth factor beta 1 induced transcript 1
 3935
 0.1
chr1_86968635_86969118 0.16 CLCA1
 chloride channel accessory 1
 34350
 0.16
chr17_42154780_42155022 0.16 G6PC3
 glucose 6 phosphatase, catalytic, 3
 2799
 0.14
chr4_113174579_113174763 0.15 AP1AR
 adaptor-related protein complex 1 associated regulatory protein
 11537
 0.15
chr11_61515322_61515473 0.15 MYRF
 myelin regulatory factor
 4724
 0.15
chr19_1907709_1907860 0.15 ADAT3
 adenosine deaminase, tRNA-specific 3
 234
 0.68
chrX_9801102_9801516 0.15 ENSG00000206844
 .
 41432
 0.15
chr12_66232016_66232167 0.15 HMGA2
 high mobility group AT-hook 2
 13188
 0.19
chr16_88827167_88827318 0.15 RP5-1142A6.8
18013
 0.07
chr19_54386339_54386490 0.15 PRKCG
 protein kinase C, gamma
 499
 0.56
chr2_99552364_99552545 0.15 KIAA1211L
 KIAA1211-like
 212
 0.96
chr8_123874992_123875143 0.15 ZHX2
 zinc fingers and homeoboxes 2
 557
 0.78
chr11_45672012_45672287 0.15 RP11-495O11.1
930
 0.62
chr19_9879532_9879683 0.15 ZNF846
 zinc finger protein 846
 197
 0.9
chr12_194668_194819 0.15 IQSEC3
 IQ motif and Sec7 domain 3
 8201
 0.17
chr16_765719_765951 0.15 METRN
 meteorin, glial cell differentiation regulator
 194
 0.8
chr2_127826599_127826750 0.15 BIN1
 bridging integrator 1
 37903
 0.18
chr8_97825590_97825741 0.15 CPQ
 carboxypeptidase Q
 52197
 0.18
chr1_85527575_85527769 0.15 WDR63
 WD repeat domain 63
 323
 0.89
chr1_42046509_42046707 0.15 RP11-486B10.3
45494
 0.16
chr2_45162375_45162583 0.15 SIX3-AS1
 SIX3 antisense RNA 1
 6154
 0.24
chr19_17641532_17641686 0.15 FAM129C
 family with sequence similarity 129, member C
 3496
 0.13
chr2_105090262_105090413 0.15 ENSG00000199727
 .
 58894
 0.15
chr7_151145465_151145709 0.15 CRYGN
 crystallin, gamma N
 8457
 0.12

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC3_ZIC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.1 0.2 GO:0003079 obsolete positive regulation of natriuresis(GO:0003079)
0.1 0.2 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1 0.3 GO:0045217 cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0 0.2 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.1 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.2 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0 0.1 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.2 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.0 0.2 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0072179 nephric duct formation(GO:0072179)
0.0 0.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.2 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:1903077 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.1 GO:0060457 negative regulation of digestive system process(GO:0060457)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0032819 positive regulation of natural killer cell proliferation(GO:0032819)
0.0 0.1 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0 0.0 GO:0032462 regulation of protein homooligomerization(GO:0032462)
0.0 0.1 GO:0021932 hindbrain radial glia guided cell migration(GO:0021932)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.1 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.0 0.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0045007 depurination(GO:0045007)
0.0 0.1 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.0 0.1 GO:0000089 mitotic metaphase(GO:0000089)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway(GO:0033145)
0.0 0.1 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.1 GO:0051014 actin filament severing(GO:0051014)
0.0 0.0 GO:0032730 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0 0.2 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.0 0.1 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.1 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.1 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.0 0.1 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.0 GO:0070572 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.0 GO:0032347 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.1 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.1 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.0 0.0 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.1 GO:0060438 trachea development(GO:0060438)
0.0 0.0 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.1 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.0 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.0 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.1 GO:0002911 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.0 0.0 GO:0032928 regulation of superoxide anion generation(GO:0032928)
0.0 0.0 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.0 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.0 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.0 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.0 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.0 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 0.0 GO:0032328 alanine transport(GO:0032328)
0.0 0.0 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.0 GO:0034201 response to oleic acid(GO:0034201)
0.0 0.1 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.2 GO:0007530 sex determination(GO:0007530)
0.0 0.1 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.0 GO:0060014 granulosa cell differentiation(GO:0060014)
0.0 0.0 GO:1901534 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.0 GO:0003181 atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0 0.1 GO:0031622 regulation of fever generation(GO:0031620) positive regulation of fever generation(GO:0031622)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.1 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.0 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.0 GO:0044254 multicellular organismal protein catabolic process(GO:0044254) protein digestion(GO:0044256) multicellular organismal macromolecule catabolic process(GO:0044266) multicellular organismal protein metabolic process(GO:0044268)
0.0 0.1 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.0 0.0 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.0 GO:0034723 DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.0 GO:0060413 atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0 0.2 GO:0007128 meiotic prophase I(GO:0007128)
0.0 0.0 GO:0042268 regulation of cytolysis(GO:0042268)
0.0 0.0 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.0 GO:0090009 primitive streak formation(GO:0090009)
0.0 0.0 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.1 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.0 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.0 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.0 GO:0008054 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0 0.1 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.1 GO:0005984 disaccharide metabolic process(GO:0005984)
0.0 0.1 GO:0007549 dosage compensation(GO:0007549)
0.0 0.1 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.1 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 0.0 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.0 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.1 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.1 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.3 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0042597 outer membrane-bounded periplasmic space(GO:0030288) periplasmic space(GO:0042597)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.5 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.0 GO:0001740 Barr body(GO:0001740)
0.0 0.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.0 GO:0017059 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.0 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0031312 extrinsic component of organelle membrane(GO:0031312)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.2 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.2 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.2 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.1 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0001228 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.3 GO:0043499 obsolete eukaryotic cell surface binding(GO:0043499)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.0 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.0 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.0 GO:0002060 purine nucleobase binding(GO:0002060)
0.0 0.1 GO:0005497 androgen binding(GO:0005497)
0.0 0.0 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.0 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.0 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.0 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.0 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.0 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.0 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.0 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.0 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.0 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.0 0.1 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.0 0.0 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.0 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.0 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.0 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0004954 prostanoid receptor activity(GO:0004954)
0.0 0.0 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.0 0.0 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.1 GO:0005112 Notch binding(GO:0005112)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.1 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.1 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.1 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.1 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.1 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.0 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.1 REACTOME POL SWITCHING Genes involved in Polymerase switching