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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZKSCAN1

Z-value: 1.47

Motif logo

Transcription factors associated with ZKSCAN1

Gene Symbol	Gene ID	Gene Info
ZKSCAN1 Ensembl NCBI GeneCards UniProt	ENSG00000106261.12	ZKSCAN1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZKSCAN1	chr7_99595503_99596097	17404	0.083160	0.81	8.8e-03	Click!
ZKSCAN1	chr7_99614173_99614425	146	0.911082	0.67	4.7e-02	Click!
ZKSCAN1	chr7_99620138_99620289	5768	0.098537	0.63	6.7e-02	Click!
ZKSCAN1	chr7_99616377_99616588	2037	0.169780	0.63	7.1e-02	Click!
ZKSCAN1	chr7_99614433_99614621	82	0.938666	0.61	8.3e-02	Click!

Activity of the ZKSCAN1 motif across conditions

Conditions sorted by the z-value of the ZKSCAN1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr17_3876410_3876657	1.82	ATP2A3	ATPase, Ca++ transporting, ubiquitous	8797	0.19
chr18_74831342_74831493	1.57	MBP	myelin basic protein	8251	0.3
chr2_437438_437589	0.88	FAM150B	family with sequence similarity 150, member B	148662	0.04
chr10_11217517_11217809	0.79	RP3-323N1.2		4324	0.25
chr19_42704508_42704707	0.74	ENSG00000265122	.	7377	0.09
chr2_231525959_231526216	0.73	CAB39	calcium binding protein 39	51473	0.12
chr17_75877100_75877282	0.73	FLJ45079		1468	0.48
chr3_13030755_13030906	0.71	IQSEC1	IQ motif and Sec7 domain 1	2294	0.4
chr1_198904768_198904950	0.69	ENSG00000207759	.	76577	0.11
chr7_949490_949865	0.69	ADAP1	ArfGAP with dual PH domains 1	4963	0.16
chr1_203291694_203291901	0.66	ENSG00000202300	.	3570	0.22
chr1_23852013_23852546	0.64	E2F2	E2F transcription factor 2	5433	0.19
chr17_21182635_21182786	0.64	MAP2K3	mitogen-activated protein kinase kinase 3	5274	0.19
chr1_27943977_27944142	0.62	FGR	feline Gardner-Rasheed sarcoma viral oncogene homolog	6514	0.15
chr6_42397272_42397459	0.62	ENSG00000221252	.	17231	0.19
chr15_77312765_77312916	0.62	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	2041	0.33
chr7_139311304_139311455	0.60	CLEC2L	C-type lectin domain family 2, member L	102551	0.07
chr16_85481767_85482285	0.59	ENSG00000264203	.	6928	0.27
chr8_142415767_142415918	0.58	CTD-3064M3.4		13168	0.12
chr7_50245194_50245403	0.58	AC020743.2		62879	0.12
chr5_55884080_55884259	0.57	AC022431.2	Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.	17890	0.22
chr17_72752966_72753168	0.57	SLC9A3R1	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	5075	0.11
chr6_11353172_11353323	0.56	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	29285	0.23
chr11_117840834_117841225	0.56	IL10RA	interleukin 10 receptor, alpha	16034	0.17
chr19_15782887_15783038	0.55	CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	605	0.72
chr17_76125845_76126093	0.54	TMC6	transmembrane channel-like 6	795	0.36
chr15_70773811_70774097	0.54	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	220666	0.02
chr16_3146298_3146516	0.54	ZSCAN10	zinc finger and SCAN domain containing 10	2822	0.09
chr20_62199024_62199397	0.53	HELZ2	helicase with zinc finger 2, transcriptional coactivator	217	0.87
chr14_91814952_91815599	0.52	ENSG00000265856	.	15218	0.22
chr14_65546707_65546994	0.52	RP11-840I19.3		1902	0.28
chr2_198077243_198077408	0.52	ANKRD44	ankyrin repeat domain 44	14563	0.2
chrX_128956937_128957088	0.51	ENSG00000266440	.	1214	0.47
chr7_97879296_97879465	0.50	TECPR1	tectonin beta-propeller repeat containing 1	1859	0.33
chr15_44968349_44968500	0.49	PATL2	protein associated with topoisomerase II homolog 2 (yeast)	324	0.85
chr7_5701558_5701816	0.49	RNF216-IT1	RNF216 intronic transcript 1 (non-protein coding)	18405	0.18
chr6_42902068_42902239	0.49	CNPY3	canopy FGF signaling regulator 3	5171	0.11
chr10_6453263_6453585	0.49	DKFZP667F0711		61146	0.14
chr1_198611512_198611708	0.49	PTPRC	protein tyrosine phosphatase, receptor type, C	3318	0.31
chr3_12716668_12716819	0.48	RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	11018	0.19
chr3_3200095_3200246	0.48	RP11-97C16.1		5544	0.18
chr1_203288364_203288515	0.48	ENSG00000202300	.	212	0.93
chr19_16476504_16477086	0.48	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	4031	0.18
chr6_150048925_150049356	0.47	LATS1	large tumor suppressor kinase 1	9748	0.14
chr1_12229589_12229973	0.47	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	2721	0.23
chr14_98638353_98638504	0.47	ENSG00000222066	.	159659	0.04
chr11_65408846_65409255	0.46	SIPA1	signal-induced proliferation-associated 1	751	0.41
chr1_12239932_12240089	0.46	ENSG00000263676	.	11760	0.15
chr5_169525252_169525403	0.46	FOXI1	forkhead box I1	7574	0.27
chr20_48889044_48889195	0.46	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	81743	0.08
chr4_40277829_40277980	0.45	CHRNA9	cholinergic receptor, nicotinic, alpha 9 (neuronal)	59442	0.11
chr19_15750443_15750594	0.45	CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	1189	0.47
chr1_12211346_12211755	0.44	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	15510	0.15
chr16_48654664_48654959	0.44	N4BP1	NEDD4 binding protein 1	10691	0.18
chr1_175180542_175180693	0.44	KIAA0040	KIAA0040	18538	0.24
chr8_38613649_38613800	0.44	TACC1	transforming, acidic coiled-coil containing protein 1	1033	0.53
chr10_126344624_126344775	0.43	FAM53B-AS1	FAM53B antisense RNA 1	47495	0.14
chr19_2489875_2490034	0.43	ENSG00000252962	.	13185	0.14
chrX_19886161_19886348	0.43	SH3KBP1	SH3-domain kinase binding protein 1	19323	0.24
chr9_136653979_136654130	0.43	SARDH	sarcosine dehydrogenase	48977	0.15
chr10_14598436_14598650	0.43	FAM107B	family with sequence similarity 107, member B	364	0.91
chr10_51499951_51500158	0.43	AGAP7	ArfGAP with GTPase domain, ankyrin repeat and PH domain 7	13727	0.2
chr19_1086467_1086654	0.42	POLR2E	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa	8793	0.09
chr10_90586675_90586853	0.42	LIPM	lipase, family member M	24059	0.15
chr1_208046544_208046843	0.42	CD34	CD34 molecule	17144	0.25
chr3_171080293_171080444	0.42	ENSG00000222506	.	76947	0.11
chr1_202127780_202127949	0.42	PTPN7	protein tyrosine phosphatase, non-receptor type 7	1255	0.37
chr15_31563928_31564079	0.42	KLF13	Kruppel-like factor 13	55055	0.15
chr12_50902770_50903124	0.41	DIP2B	DIP2 disco-interacting protein 2 homolog B (Drosophila)	4057	0.27
chr5_176796790_176797014	0.41	RGS14	regulator of G-protein signaling 14	2958	0.13
chr6_41240534_41240685	0.41	TREM1	triggering receptor expressed on myeloid cells 1	13794	0.13
chr17_9966141_9966338	0.41	GAS7	growth arrest-specific 7	1543	0.42
chr19_49121679_49121830	0.41	RPL18	ribosomal protein L18	613	0.39
chr19_10831404_10831582	0.41	DNM2	dynamin 2	2256	0.18
chr2_101260265_101260620	0.40	ENSG00000265839	.	43114	0.15
chr19_2274369_2274549	0.40	OAZ1	ornithine decarboxylase antizyme 1	4169	0.09
chr17_18947608_18947759	0.40	GRAP	GRB2-related adaptor protein	1885	0.21
chr7_5370188_5370339	0.40	TNRC18	trinucleotide repeat containing 18	2246	0.29
chr13_99911046_99911220	0.39	GPR18	G protein-coupled receptor 18	451	0.83
chr6_42015063_42015705	0.39	CCND3	cyclin D3	1040	0.46
chr5_169706251_169706453	0.39	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	12021	0.22
chr2_233083519_233083826	0.39	ENSG00000207626	.	46309	0.14
chr10_70856277_70856489	0.39	SRGN	serglycin	8509	0.19
chr1_221951817_221951998	0.39	DUSP10	dual specificity phosphatase 10	36389	0.21
chr5_177240356_177240599	0.39	FAM153A	family with sequence similarity 153, member A	30078	0.13
chr10_90593085_90593348	0.38	ANKRD22	ankyrin repeat domain 22	18359	0.16
chr22_27074499_27074686	0.38	CRYBA4	crystallin, beta A4	56664	0.12
chr11_76091036_76091263	0.38	PRKRIR	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	837	0.42
chr9_137137039_137137190	0.38	RXRA	retinoid X receptor, alpha	81312	0.09
chr11_67212387_67212841	0.38	CORO1B	coronin, actin binding protein, 1B	1351	0.18
chr10_74081918_74082189	0.38	DNAJB12	DnaJ (Hsp40) homolog, subfamily B, member 12	22666	0.16
chr10_97597159_97597443	0.38	RP11-429G19.3		4036	0.26
chr1_23925674_23925825	0.38	MDS2	myelodysplastic syndrome 2 translocation associated	28075	0.14
chr13_96335043_96335194	0.38	DNAJC3	DnaJ (Hsp40) homolog, subfamily C, member 3	5706	0.23
chr20_31174503_31174689	0.38	RP11-410N8.4		685	0.59
chr10_11740535_11740686	0.38	ECHDC3	enoyl CoA hydratase domain containing 3	43755	0.16
chr12_57913214_57913504	0.38	ENSG00000208028	.	317	0.62
chr5_159913380_159913531	0.38	ENSG00000253522	.	1096	0.49
chr12_121272474_121272747	0.37	SPPL3	signal peptide peptidase like 3	850	0.61
chr19_11517184_11517450	0.37	ENSG00000202357	.	2131	0.14
chr5_67562733_67562884	0.37	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	13260	0.27
chr2_28880167_28880318	0.37	AC074011.2		7164	0.19
chr2_114018866_114019227	0.37	ENSG00000189223	.	6080	0.17
chr9_134155011_134155162	0.37	FAM78A	family with sequence similarity 78, member A	3152	0.23
chr16_3138152_3138303	0.37	ENSG00000200204	.	2083	0.11
chr5_134240040_134240274	0.37	PCBD2	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	439	0.8
chr5_175457280_175457431	0.37	THOC3	THO complex 3	4328	0.17
chr15_60863549_60863700	0.36	RORA	RAR-related orphan receptor A	21116	0.19
chr11_48062772_48062967	0.36	AC103828.1		25462	0.18
chr10_494842_494993	0.36	RP11-490E15.2		11416	0.2
chr19_42376134_42376473	0.36	CD79A	CD79a molecule, immunoglobulin-associated alpha	4887	0.12
chr22_40450666_40450817	0.36	TNRC6B	trinucleotide repeat containing 6B	9263	0.19
chr3_32179971_32180291	0.35	GPD1L	glycerol-3-phosphate dehydrogenase 1-like	31940	0.15
chr3_71768573_71768891	0.35	EIF4E3	eukaryotic translation initiation factor 4E family member 3	5794	0.24
chr1_54946013_54946309	0.35	ENSG00000265404	.	24180	0.16
chr17_71981136_71981299	0.35	RPL38	ribosomal protein L38	218504	0.02
chr17_47471640_47471845	0.35	RP11-1079K10.4		9701	0.11
chr10_80907133_80907284	0.35	ZMIZ1	zinc finger, MIZ-type containing 1	78416	0.1
chr19_3178230_3178381	0.35	S1PR4	sphingosine-1-phosphate receptor 4	431	0.74
chr12_110290929_110291080	0.35	ENSG00000241413	.	13310	0.13
chr1_27940236_27940387	0.35	AHDC1	AT hook, DNA binding motif, containing 1	10168	0.14
chr16_30192495_30192646	0.34	CORO1A	coronin, actin binding protein, 1A	1578	0.18
chr11_46367187_46367549	0.34	DGKZ	diacylglycerol kinase, zeta	381	0.82
chr11_75111382_75111533	0.34	RPS3	ribosomal protein S3	9	0.5
chr22_40309826_40310035	0.34	GRAP2	GRB2-related adaptor protein 2	12665	0.17
chr2_12318593_12318886	0.34	ENSG00000264089	.	20517	0.27
chr17_80821237_80821457	0.34	TBCD	tubulin folding cofactor D	3077	0.23
chr15_31633419_31633718	0.34	KLF13	Kruppel-like factor 13	1432	0.57
chr18_9153404_9153628	0.34	ANKRD12	ankyrin repeat domain 12	15955	0.15
chr22_40527439_40527729	0.33	TNRC6B	trinucleotide repeat containing 6B	46345	0.15
chr9_131998104_131998424	0.33	ENSG00000220992	.	5268	0.19
chr12_107766943_107767139	0.33	ENSG00000200897	.	1483	0.51
chr11_61197700_61198009	0.33	SDHAF2	succinate dehydrogenase complex assembly factor 2	238	0.44
chr19_10746196_10746374	0.33	SLC44A2	solute carrier family 44 (choline transporter), member 2	2035	0.19
chr1_25970325_25970699	0.32	RP1-187B23.1		15090	0.18
chr20_57733456_57733718	0.32	ZNF831	zinc finger protein 831	32488	0.19
chr11_73091795_73092090	0.32	RELT	RELT tumor necrosis factor receptor	4229	0.17
chr17_33221100_33221251	0.32	CCT6B	chaperonin containing TCP1, subunit 6B (zeta 2)	67246	0.09
chr17_73649033_73649246	0.32	SMIM6	small integral membrane protein 6	6622	0.1
chr11_6423240_6423565	0.32	APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	2492	0.21
chr2_46926793_46927032	0.32	SOCS5	suppressor of cytokine signaling 5	586	0.78
chr17_65434813_65435235	0.32	ENSG00000244610	.	18382	0.13
chr4_6941984_6942245	0.32	ENSG00000265953	.	12902	0.15
chr22_27083769_27083920	0.32	CRYBA4	crystallin, beta A4	65916	0.11
chr10_114141969_114142120	0.32	ACSL5	acyl-CoA synthetase long-chain family member 5	6087	0.2
chr1_54814987_54815138	0.32	SSBP3	single stranded DNA binding protein 3	56115	0.11
chr9_137281945_137282096	0.32	ENSG00000263897	.	10763	0.23
chr1_225608177_225608328	0.32	LBR	lamin B receptor	7347	0.19
chr3_46278155_46278310	0.31	CCR3	chemokine (C-C motif) receptor 3	5640	0.23
chr19_54722925_54723182	0.31	LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	3797	0.09
chr17_56403632_56403944	0.31	BZRAP1-AS1	BZRAP1 antisense RNA 1	977	0.36
chr1_53703818_53703969	0.31	MAGOH	mago-nashi homolog, proliferation-associated (Drosophila)	278	0.56
chr16_75094649_75094937	0.31	ZNRF1	zinc and ring finger 1, E3 ubiquitin protein ligase	43889	0.12
chr19_18285022_18285173	0.31	IFI30	interferon, gamma-inducible protein 30	620	0.57
chr16_4364379_4364530	0.31	GLIS2	GLIS family zinc finger 2	308	0.85
chr1_111203801_111203979	0.31	ENSG00000221538	.	8237	0.18
chr3_15369856_15370007	0.31	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	4136	0.17
chr16_17545376_17545755	0.31	XYLT1	xylosyltransferase I	19173	0.3
chr14_74241491_74241738	0.30	ELMSAN1	ELM2 and Myb/SANT-like domain containing 1	12347	0.11
chr1_247332601_247332804	0.30	ZNF124	zinc finger protein 124	2567	0.22
chr12_3863154_3863452	0.30	EFCAB4B	EF-hand calcium binding domain 4B	937	0.65
chr18_13219395_13219546	0.30	LDLRAD4	low density lipoprotein receptor class A domain containing 4	684	0.66
chr14_103113093_103113249	0.30	ENSG00000202459	.	48554	0.11
chr2_8201184_8201335	0.30	ENSG00000221255	.	484287	0.01
chr5_173202423_173202604	0.30	ENSG00000263401	.	45432	0.18
chr20_31129022_31129283	0.30	C20orf112	chromosome 20 open reading frame 112	4952	0.19
chr11_60789970_60790185	0.30	CD6	CD6 molecule	14071	0.14
chr22_40336508_40336741	0.30	GRAP2	GRB2-related adaptor protein 2	6197	0.18
chr14_92912996_92913173	0.30	SLC24A4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	7376	0.28
chr9_135897951_135898139	0.30	GTF3C5	general transcription factor IIIC, polypeptide 5, 63kDa	8031	0.14
chr14_60693586_60693737	0.30	CTD-2184C24.2		18393	0.19
chr19_42956472_42956792	0.30	LIPE-AS1	LIPE antisense RNA 1	8368	0.12
chr2_213879689_213879840	0.30	AC079610.1		6505	0.31
chr13_25202028_25202179	0.30	ENSG00000211508	.	18886	0.18
chr14_54977048_54977291	0.30	CGRRF1	cell growth regulator with ring finger domain 1	545	0.79
chr18_21582787_21583054	0.30	TTC39C	tetratricopeptide repeat domain 39C	10183	0.18
chr3_50653123_50653503	0.29	MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	1249	0.38
chr10_11131193_11131344	0.29	CELF2-AS2	CELF2 antisense RNA 2	8855	0.23
chr21_46047532_46047683	0.29	KRTAP10-9	keratin associated protein 10-9	567	0.52
chr20_31056876_31057055	0.29	C20orf112	chromosome 20 open reading frame 112	14309	0.17
chr11_94997219_94997453	0.29	RP11-712B9.2		31601	0.19
chr12_93492296_93492447	0.29	ENSG00000221617	.	1344	0.49
chr3_13021430_13021581	0.29	IQSEC1	IQ motif and Sec7 domain 1	7031	0.28
chr7_155785095_155785246	0.29	AC021218.2	Uncharacterized protein	29844	0.23
chr19_9946433_9946665	0.29	PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	532	0.58
chr19_8400659_8400845	0.29	KANK3	KN motif and ankyrin repeat domains 3	7394	0.1
chr1_226835966_226836117	0.29	ITPKB-IT1	ITPKB intronic transcript 1 (non-protein coding)	11330	0.21
chr11_48018118_48018305	0.29	PTPRJ	protein tyrosine phosphatase, receptor type, J	15932	0.19
chr12_89638036_89638195	0.29	ENSG00000238302	.	37947	0.21
chr6_126230387_126230538	0.29	NCOA7	nuclear receptor coactivator 7	9407	0.19
chr11_65552908_65553161	0.29	OVOL1	ovo-like zinc finger 1	1459	0.22
chr12_105044364_105044605	0.29	ENSG00000264295	.	59073	0.13
chr19_7929180_7929331	0.29	EVI5L	ecotropic viral integration site 5-like	3784	0.1
chrX_12972828_12973236	0.28	TMSB4X	thymosin beta 4, X-linked	20195	0.19
chr8_131020536_131020825	0.28	ENSG00000264653	.	19	0.97
chr1_1827398_1827549	0.28	RP1-140A9.1		4563	0.14
chr14_70165157_70165557	0.28	SRSF5	serine/arginine-rich splicing factor 5	28260	0.2
chr15_77291917_77292573	0.28	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	4330	0.22
chr16_17475953_17476212	0.28	XYLT1	xylosyltransferase I	88656	0.11
chr20_1946593_1946814	0.28	RP4-684O24.5		18811	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1	0.1	GO:0070669	response to interleukin-2(GO:0070669)
0.1	0.2	GO:0033004	negative regulation of mast cell activation(GO:0033004)
0.1	0.1	GO:0045591	positive regulation of regulatory T cell differentiation(GO:0045591)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.1	GO:0072338	allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.2	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.1	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.2	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.3	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.2	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.0	GO:0070141	response to UV-A(GO:0070141)
0.0	0.2	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.2	GO:0043049	otic placode formation(GO:0043049)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:1901985	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.2	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.1	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.0	GO:0070423	cytoplasmic pattern recognition receptor signaling pathway(GO:0002753) nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway(GO:0035872) nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.0	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.1	GO:0060157	urinary bladder development(GO:0060157)
0.0	0.5	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.2	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.2	GO:0002478	antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0	0.2	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.1	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.0	0.3	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:0030422	production of siRNA involved in RNA interference(GO:0030422)
0.0	0.1	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.2	GO:2001021	negative regulation of response to DNA damage stimulus(GO:2001021)
0.0	0.1	GO:0035844	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.1	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.2	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.1	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.2	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0	0.1	GO:0070570	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.1	GO:1903313	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.1	GO:0072033	renal vesicle formation(GO:0072033)
0.0	0.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.4	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.1	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.0	GO:0019884	antigen processing and presentation of exogenous antigen(GO:0019884)
0.0	0.0	GO:0070244	negative regulation of thymocyte apoptotic process(GO:0070244)
0.0	0.2	GO:0051131	chaperone-mediated protein complex assembly(GO:0051131)
0.0	0.6	GO:0050771	negative regulation of axonogenesis(GO:0050771)
0.0	0.1	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0046885	regulation of hormone biosynthetic process(GO:0046885)
0.0	0.1	GO:0002327	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.0	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546)
0.0	0.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.1	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0	0.1	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.0	0.0	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.0	GO:0048263	determination of dorsal identity(GO:0048263)
0.0	0.1	GO:0048617	embryonic foregut morphogenesis(GO:0048617)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.0	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0034135	regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.0	0.4	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0045007	depurination(GO:0045007)
0.0	0.0	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0045683	negative regulation of epidermal cell differentiation(GO:0045605) negative regulation of epidermis development(GO:0045683)
0.0	0.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.0	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.0	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.1	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.3	GO:0045646	regulation of erythrocyte differentiation(GO:0045646)
0.0	0.2	GO:0000085	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0046498	S-adenosylhomocysteine metabolic process(GO:0046498)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.0	GO:0051788	response to misfolded protein(GO:0051788)
0.0	0.0	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0	0.0	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0000239	pachytene(GO:0000239)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0031269	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.0	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.0	0.0	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.0	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.0	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) membrane raft localization(GO:0051665)
0.0	0.4	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.1	GO:0035082	axoneme assembly(GO:0035082)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.0	GO:0043301	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0	0.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.1	GO:0042346	positive regulation of NF-kappaB import into nucleus(GO:0042346)
0.0	0.0	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.1	GO:0043029	T cell homeostasis(GO:0043029)
0.0	0.0	GO:0051446	positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.0	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.0	0.0	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.0	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.0	GO:0000154	rRNA modification(GO:0000154)
0.0	0.1	GO:0042094	interleukin-2 biosynthetic process(GO:0042094)
0.0	0.0	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.0	GO:0061384	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.0	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.0	0.3	GO:0006691	leukotriene metabolic process(GO:0006691)
0.0	0.0	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	0.0	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.0	0.1	GO:0018065	protein-cofactor linkage(GO:0018065)
0.0	0.1	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.2	GO:0045576	mast cell activation(GO:0045576)
0.0	0.0	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.1	GO:0030238	male sex determination(GO:0030238)
0.0	0.1	GO:0001961	positive regulation of cytokine-mediated signaling pathway(GO:0001961)
0.0	0.1	GO:0050869	negative regulation of B cell activation(GO:0050869)
0.0	0.0	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.1	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.3	GO:0051318	G1 phase(GO:0051318)
0.0	0.1	GO:0006000	fructose metabolic process(GO:0006000)
0.0	0.1	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.0	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.1	GO:0000303	response to superoxide(GO:0000303)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0007506	gonadal mesoderm development(GO:0007506)
0.0	0.2	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.0	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.1	GO:0045671	negative regulation of osteoclast differentiation(GO:0045671)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.0	GO:0042670	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)
0.0	0.2	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0043218	compact myelin(GO:0043218)
0.1	0.5	GO:0005826	actomyosin contractile ring(GO:0005826)
0.1	0.2	GO:0001940	male pronucleus(GO:0001940)
0.1	0.4	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.1	GO:0044462	external encapsulating structure part(GO:0044462)
0.0	0.2	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.1	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.3	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.2	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.1	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.0	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.3	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.0	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.1	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.0	GO:0002141	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.1	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.2	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.0	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0000346	transcription export complex(GO:0000346)
0.0	0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.3	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.0	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.1	GO:0005732	small nucleolar ribonucleoprotein complex(GO:0005732)
0.0	0.2	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	0.3	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.1	0.4	GO:0001727	lipid kinase activity(GO:0001727)
0.1	0.2	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	0.2	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.3	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.4	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.2	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.2	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.5	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.5	GO:0070330	aromatase activity(GO:0070330)
0.0	0.2	GO:0035381	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0	0.4	GO:0070001	aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0	0.2	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0	0.1	GO:1901567	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.1	GO:0017081	chloride channel regulator activity(GO:0017081)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.4	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.2	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.1	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.2	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.2	GO:0005123	death receptor binding(GO:0005123)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.2	GO:0003840	gamma-glutamyltransferase activity(GO:0003840)
0.0	0.2	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.1	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.0	GO:0032296	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.0	GO:0035014	phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.2	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.5	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.1	GO:0004950	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0004396	hexokinase activity(GO:0004396)
0.0	0.1	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.0	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.0	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.0	GO:0016416	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.0	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0	0.1	GO:0016944	obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0	0.0	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.0	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.0	GO:0005035	death receptor activity(GO:0005035)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.0	GO:0070053	thrombospondin receptor activity(GO:0070053)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.6	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.4	PID IL5 PATHWAY	IL5-mediated signaling events
0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.4	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.6	PID ARF6 PATHWAY	Arf6 signaling events
0.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.7	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.5	PID IL12 2PATHWAY	IL12-mediated signaling events
0.1	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3	PID BCR 5PATHWAY	BCR signaling pathway
0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.5	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.1	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.4	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.3	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.3	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.3	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.4	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.2	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.1	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	REACTOME SIGNALING BY NOTCH4	Genes involved in Signaling by NOTCH4
0.2	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.7	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.3	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.1	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.1	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	REACTOME SIGNAL AMPLIFICATION	Genes involved in Signal amplification
0.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.3	REACTOME G1 PHASE	Genes involved in G1 Phase
0.1	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.3	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC