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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for ZKSCAN1

Z-value: 1.47

Motif logo

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Transcription factors associated with ZKSCAN1

Gene Symbol Gene ID Gene Info
ZKSCAN1
ENSG00000106261.12 zinc finger with KRAB and SCAN domains 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr7_99595503_99596097ZKSCAN1174040.0831600.818.8e-03Click!
chr7_99614173_99614425ZKSCAN11460.9110820.674.7e-02Click!
chr7_99620138_99620289ZKSCAN157680.0985370.636.7e-02Click!
chr7_99616377_99616588ZKSCAN120370.1697800.637.1e-02Click!
chr7_99614433_99614621ZKSCAN1820.9386660.618.3e-02Click!

Activity of the ZKSCAN1 motif across conditions

Conditions sorted by the z-value of the ZKSCAN1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr17_3876410_3876657 1.82 ATP2A3
 ATPase, Ca++ transporting, ubiquitous
 8797
 0.19
chr18_74831342_74831493 1.57 MBP
 myelin basic protein
 8251
 0.3
chr2_437438_437589 0.88 FAM150B
 family with sequence similarity 150, member B
 148662
 0.04
chr10_11217517_11217809 0.79 RP3-323N1.2
4324
 0.25
chr19_42704508_42704707 0.74 ENSG00000265122
 .
 7377
 0.09
chr2_231525959_231526216 0.73 CAB39
 calcium binding protein 39
 51473
 0.12
chr17_75877100_75877282 0.73 FLJ45079
1468
 0.48
chr3_13030755_13030906 0.71 IQSEC1
 IQ motif and Sec7 domain 1
 2294
 0.4
chr1_198904768_198904950 0.69 ENSG00000207759
 .
 76577
 0.11
chr7_949490_949865 0.69 ADAP1
 ArfGAP with dual PH domains 1
 4963
 0.16
chr1_203291694_203291901 0.66 ENSG00000202300
 .
 3570
 0.22
chr1_23852013_23852546 0.64 E2F2
 E2F transcription factor 2
 5433
 0.19
chr17_21182635_21182786 0.64 MAP2K3
 mitogen-activated protein kinase kinase 3
 5274
 0.19
chr1_27943977_27944142 0.62 FGR
 feline Gardner-Rasheed sarcoma viral oncogene homolog
 6514
 0.15
chr6_42397272_42397459 0.62 ENSG00000221252
 .
 17231
 0.19
chr15_77312765_77312916 0.62 PSTPIP1
 proline-serine-threonine phosphatase interacting protein 1
 2041
 0.33
chr7_139311304_139311455 0.60 CLEC2L
 C-type lectin domain family 2, member L
 102551
 0.07
chr16_85481767_85482285 0.59 ENSG00000264203
 .
 6928
 0.27
chr8_142415767_142415918 0.58 CTD-3064M3.4
13168
 0.12
chr7_50245194_50245403 0.58 AC020743.2
62879
 0.12
chr5_55884080_55884259 0.57 AC022431.2
 Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.
 17890
 0.22
chr17_72752966_72753168 0.57 SLC9A3R1
 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
 5075
 0.11
chr6_11353172_11353323 0.56 NEDD9
 neural precursor cell expressed, developmentally down-regulated 9
 29285
 0.23
chr11_117840834_117841225 0.56 IL10RA
 interleukin 10 receptor, alpha
 16034
 0.17
chr19_15782887_15783038 0.55 CYP4F12
 cytochrome P450, family 4, subfamily F, polypeptide 12
 605
 0.72
chr17_76125845_76126093 0.54 TMC6
 transmembrane channel-like 6
 795
 0.36
chr15_70773811_70774097 0.54 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 220666
 0.02
chr16_3146298_3146516 0.54 ZSCAN10
 zinc finger and SCAN domain containing 10
 2822
 0.09
chr20_62199024_62199397 0.53 HELZ2
 helicase with zinc finger 2, transcriptional coactivator
 217
 0.87
chr14_91814952_91815599 0.52 ENSG00000265856
 .
 15218
 0.22
chr14_65546707_65546994 0.52 RP11-840I19.3
1902
 0.28
chr2_198077243_198077408 0.52 ANKRD44
 ankyrin repeat domain 44
 14563
 0.2
chrX_128956937_128957088 0.51 ENSG00000266440
 .
 1214
 0.47
chr7_97879296_97879465 0.50 TECPR1
 tectonin beta-propeller repeat containing 1
 1859
 0.33
chr15_44968349_44968500 0.49 PATL2
 protein associated with topoisomerase II homolog 2 (yeast)
 324
 0.85
chr7_5701558_5701816 0.49 RNF216-IT1
 RNF216 intronic transcript 1 (non-protein coding)
 18405
 0.18
chr6_42902068_42902239 0.49 CNPY3
 canopy FGF signaling regulator 3
 5171
 0.11
chr10_6453263_6453585 0.49 DKFZP667F0711
61146
 0.14
chr1_198611512_198611708 0.49 PTPRC
 protein tyrosine phosphatase, receptor type, C
 3318
 0.31
chr3_12716668_12716819 0.48 RAF1
 v-raf-1 murine leukemia viral oncogene homolog 1
 11018
 0.19
chr3_3200095_3200246 0.48 RP11-97C16.1
5544
 0.18
chr1_203288364_203288515 0.48 ENSG00000202300
 .
 212
 0.93
chr19_16476504_16477086 0.48 EPS15L1
 epidermal growth factor receptor pathway substrate 15-like 1
 4031
 0.18
chr6_150048925_150049356 0.47 LATS1
 large tumor suppressor kinase 1
 9748
 0.14
chr1_12229589_12229973 0.47 TNFRSF1B
 tumor necrosis factor receptor superfamily, member 1B
 2721
 0.23
chr14_98638353_98638504 0.47 ENSG00000222066
 .
 159659
 0.04
chr11_65408846_65409255 0.46 SIPA1
 signal-induced proliferation-associated 1
 751
 0.41
chr1_12239932_12240089 0.46 ENSG00000263676
 .
 11760
 0.15
chr5_169525252_169525403 0.46 FOXI1
 forkhead box I1
 7574
 0.27
chr20_48889044_48889195 0.46 CEBPB
 CCAAT/enhancer binding protein (C/EBP), beta
 81743
 0.08
chr4_40277829_40277980 0.45 CHRNA9
 cholinergic receptor, nicotinic, alpha 9 (neuronal)
 59442
 0.11
chr19_15750443_15750594 0.45 CYP4F3
 cytochrome P450, family 4, subfamily F, polypeptide 3
 1189
 0.47
chr1_12211346_12211755 0.44 TNFRSF1B
 tumor necrosis factor receptor superfamily, member 1B
 15510
 0.15
chr16_48654664_48654959 0.44 N4BP1
 NEDD4 binding protein 1
 10691
 0.18
chr1_175180542_175180693 0.44 KIAA0040
 KIAA0040
 18538
 0.24
chr8_38613649_38613800 0.44 TACC1
 transforming, acidic coiled-coil containing protein 1
 1033
 0.53
chr10_126344624_126344775 0.43 FAM53B-AS1
 FAM53B antisense RNA 1
 47495
 0.14
chr19_2489875_2490034 0.43 ENSG00000252962
 .
 13185
 0.14
chrX_19886161_19886348 0.43 SH3KBP1
 SH3-domain kinase binding protein 1
 19323
 0.24
chr9_136653979_136654130 0.43 SARDH
 sarcosine dehydrogenase
 48977
 0.15
chr10_14598436_14598650 0.43 FAM107B
 family with sequence similarity 107, member B
 364
 0.91
chr10_51499951_51500158 0.43 AGAP7
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 7
 13727
 0.2
chr19_1086467_1086654 0.42 POLR2E
 polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
 8793
 0.09
chr10_90586675_90586853 0.42 LIPM
 lipase, family member M
 24059
 0.15
chr1_208046544_208046843 0.42 CD34
 CD34 molecule
 17144
 0.25
chr3_171080293_171080444 0.42 ENSG00000222506
 .
 76947
 0.11
chr1_202127780_202127949 0.42 PTPN7
 protein tyrosine phosphatase, non-receptor type 7
 1255
 0.37
chr15_31563928_31564079 0.42 KLF13
 Kruppel-like factor 13
 55055
 0.15
chr12_50902770_50903124 0.41 DIP2B
 DIP2 disco-interacting protein 2 homolog B (Drosophila)
 4057
 0.27
chr5_176796790_176797014 0.41 RGS14
 regulator of G-protein signaling 14
 2958
 0.13
chr6_41240534_41240685 0.41 TREM1
 triggering receptor expressed on myeloid cells 1
 13794
 0.13
chr17_9966141_9966338 0.41 GAS7
 growth arrest-specific 7
 1543
 0.42
chr19_49121679_49121830 0.41 RPL18
 ribosomal protein L18
 613
 0.39
chr19_10831404_10831582 0.41 DNM2
 dynamin 2
 2256
 0.18
chr2_101260265_101260620 0.40 ENSG00000265839
 .
 43114
 0.15
chr19_2274369_2274549 0.40 OAZ1
 ornithine decarboxylase antizyme 1
 4169
 0.09
chr17_18947608_18947759 0.40 GRAP
 GRB2-related adaptor protein
 1885
 0.21
chr7_5370188_5370339 0.40 TNRC18
 trinucleotide repeat containing 18
 2246
 0.29
chr13_99911046_99911220 0.39 GPR18
 G protein-coupled receptor 18
 451
 0.83
chr6_42015063_42015705 0.39 CCND3
 cyclin D3
 1040
 0.46
chr5_169706251_169706453 0.39 LCP2
 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
 12021
 0.22
chr2_233083519_233083826 0.39 ENSG00000207626
 .
 46309
 0.14
chr10_70856277_70856489 0.39 SRGN
 serglycin
 8509
 0.19
chr1_221951817_221951998 0.39 DUSP10
 dual specificity phosphatase 10
 36389
 0.21
chr5_177240356_177240599 0.39 FAM153A
 family with sequence similarity 153, member A
 30078
 0.13
chr10_90593085_90593348 0.38 ANKRD22
 ankyrin repeat domain 22
 18359
 0.16
chr22_27074499_27074686 0.38 CRYBA4
 crystallin, beta A4
 56664
 0.12
chr11_76091036_76091263 0.38 PRKRIR
 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
 837
 0.42
chr9_137137039_137137190 0.38 RXRA
 retinoid X receptor, alpha
 81312
 0.09
chr11_67212387_67212841 0.38 CORO1B
 coronin, actin binding protein, 1B
 1351
 0.18
chr10_74081918_74082189 0.38 DNAJB12
 DnaJ (Hsp40) homolog, subfamily B, member 12
 22666
 0.16
chr10_97597159_97597443 0.38 RP11-429G19.3
4036
 0.26
chr1_23925674_23925825 0.38 MDS2
 myelodysplastic syndrome 2 translocation associated
 28075
 0.14
chr13_96335043_96335194 0.38 DNAJC3
 DnaJ (Hsp40) homolog, subfamily C, member 3
 5706
 0.23
chr20_31174503_31174689 0.38 RP11-410N8.4
685
 0.59
chr10_11740535_11740686 0.38 ECHDC3
 enoyl CoA hydratase domain containing 3
 43755
 0.16
chr12_57913214_57913504 0.38 ENSG00000208028
 .
 317
 0.62
chr5_159913380_159913531 0.38 ENSG00000253522
 .
 1096
 0.49
chr12_121272474_121272747 0.37 SPPL3
 signal peptide peptidase like 3
 850
 0.61
chr19_11517184_11517450 0.37 ENSG00000202357
 .
 2131
 0.14
chr5_67562733_67562884 0.37 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 13260
 0.27
chr2_28880167_28880318 0.37 AC074011.2
7164
 0.19
chr2_114018866_114019227 0.37 ENSG00000189223
 .
 6080
 0.17
chr9_134155011_134155162 0.37 FAM78A
 family with sequence similarity 78, member A
 3152
 0.23
chr16_3138152_3138303 0.37 ENSG00000200204
 .
 2083
 0.11
chr5_134240040_134240274 0.37 PCBD2
 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
 439
 0.8
chr5_175457280_175457431 0.37 THOC3
 THO complex 3
 4328
 0.17
chr15_60863549_60863700 0.36 RORA
 RAR-related orphan receptor A
 21116
 0.19
chr11_48062772_48062967 0.36 AC103828.1
25462
 0.18
chr10_494842_494993 0.36 RP11-490E15.2
11416
 0.2
chr19_42376134_42376473 0.36 CD79A
 CD79a molecule, immunoglobulin-associated alpha
 4887
 0.12
chr22_40450666_40450817 0.36 TNRC6B
 trinucleotide repeat containing 6B
 9263
 0.19
chr3_32179971_32180291 0.35 GPD1L
 glycerol-3-phosphate dehydrogenase 1-like
 31940
 0.15
chr3_71768573_71768891 0.35 EIF4E3
 eukaryotic translation initiation factor 4E family member 3
 5794
 0.24
chr1_54946013_54946309 0.35 ENSG00000265404
 .
 24180
 0.16
chr17_71981136_71981299 0.35 RPL38
 ribosomal protein L38
 218504
 0.02
chr17_47471640_47471845 0.35 RP11-1079K10.4
9701
 0.11
chr10_80907133_80907284 0.35 ZMIZ1
 zinc finger, MIZ-type containing 1
 78416
 0.1
chr19_3178230_3178381 0.35 S1PR4
 sphingosine-1-phosphate receptor 4
 431
 0.74
chr12_110290929_110291080 0.35 ENSG00000241413
 .
 13310
 0.13
chr1_27940236_27940387 0.35 AHDC1
 AT hook, DNA binding motif, containing 1
 10168
 0.14
chr16_30192495_30192646 0.34 CORO1A
 coronin, actin binding protein, 1A
 1578
 0.18
chr11_46367187_46367549 0.34 DGKZ
 diacylglycerol kinase, zeta
 381
 0.82
chr11_75111382_75111533 0.34 RPS3
 ribosomal protein S3
 9
 0.5
chr22_40309826_40310035 0.34 GRAP2
 GRB2-related adaptor protein 2
 12665
 0.17
chr2_12318593_12318886 0.34 ENSG00000264089
 .
 20517
 0.27
chr17_80821237_80821457 0.34 TBCD
 tubulin folding cofactor D
 3077
 0.23
chr15_31633419_31633718 0.34 KLF13
 Kruppel-like factor 13
 1432
 0.57
chr18_9153404_9153628 0.34 ANKRD12
 ankyrin repeat domain 12
 15955
 0.15
chr22_40527439_40527729 0.33 TNRC6B
 trinucleotide repeat containing 6B
 46345
 0.15
chr9_131998104_131998424 0.33 ENSG00000220992
 .
 5268
 0.19
chr12_107766943_107767139 0.33 ENSG00000200897
 .
 1483
 0.51
chr11_61197700_61198009 0.33 SDHAF2
 succinate dehydrogenase complex assembly factor 2
 238
 0.44
chr19_10746196_10746374 0.33 SLC44A2
 solute carrier family 44 (choline transporter), member 2
 2035
 0.19
chr1_25970325_25970699 0.32 RP1-187B23.1
15090
 0.18
chr20_57733456_57733718 0.32 ZNF831
 zinc finger protein 831
 32488
 0.19
chr11_73091795_73092090 0.32 RELT
 RELT tumor necrosis factor receptor
 4229
 0.17
chr17_33221100_33221251 0.32 CCT6B
 chaperonin containing TCP1, subunit 6B (zeta 2)
 67246
 0.09
chr17_73649033_73649246 0.32 SMIM6
 small integral membrane protein 6
 6622
 0.1
chr11_6423240_6423565 0.32 APBB1
 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
 2492
 0.21
chr2_46926793_46927032 0.32 SOCS5
 suppressor of cytokine signaling 5
 586
 0.78
chr17_65434813_65435235 0.32 ENSG00000244610
 .
 18382
 0.13
chr4_6941984_6942245 0.32 ENSG00000265953
 .
 12902
 0.15
chr22_27083769_27083920 0.32 CRYBA4
 crystallin, beta A4
 65916
 0.11
chr10_114141969_114142120 0.32 ACSL5
 acyl-CoA synthetase long-chain family member 5
 6087
 0.2
chr1_54814987_54815138 0.32 SSBP3
 single stranded DNA binding protein 3
 56115
 0.11
chr9_137281945_137282096 0.32 ENSG00000263897
 .
 10763
 0.23
chr1_225608177_225608328 0.32 LBR
 lamin B receptor
 7347
 0.19
chr3_46278155_46278310 0.31 CCR3
 chemokine (C-C motif) receptor 3
 5640
 0.23
chr19_54722925_54723182 0.31 LILRB3
 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
 3797
 0.09
chr17_56403632_56403944 0.31 BZRAP1-AS1
 BZRAP1 antisense RNA 1
 977
 0.36
chr1_53703818_53703969 0.31 MAGOH
 mago-nashi homolog, proliferation-associated (Drosophila)
 278
 0.56
chr16_75094649_75094937 0.31 ZNRF1
 zinc and ring finger 1, E3 ubiquitin protein ligase
 43889
 0.12
chr19_18285022_18285173 0.31 IFI30
 interferon, gamma-inducible protein 30
 620
 0.57
chr16_4364379_4364530 0.31 GLIS2
 GLIS family zinc finger 2
 308
 0.85
chr1_111203801_111203979 0.31 ENSG00000221538
 .
 8237
 0.18
chr3_15369856_15370007 0.31 SH3BP5
 SH3-domain binding protein 5 (BTK-associated)
 4136
 0.17
chr16_17545376_17545755 0.31 XYLT1
 xylosyltransferase I
 19173
 0.3
chr14_74241491_74241738 0.30 ELMSAN1
 ELM2 and Myb/SANT-like domain containing 1
 12347
 0.11
chr1_247332601_247332804 0.30 ZNF124
 zinc finger protein 124
 2567
 0.22
chr12_3863154_3863452 0.30 EFCAB4B
 EF-hand calcium binding domain 4B
 937
 0.65
chr18_13219395_13219546 0.30 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
 684
 0.66
chr14_103113093_103113249 0.30 ENSG00000202459
 .
 48554
 0.11
chr2_8201184_8201335 0.30 ENSG00000221255
 .
 484287
 0.01
chr5_173202423_173202604 0.30 ENSG00000263401
 .
 45432
 0.18
chr20_31129022_31129283 0.30 C20orf112
 chromosome 20 open reading frame 112
 4952
 0.19
chr11_60789970_60790185 0.30 CD6
 CD6 molecule
 14071
 0.14
chr22_40336508_40336741 0.30 GRAP2
 GRB2-related adaptor protein 2
 6197
 0.18
chr14_92912996_92913173 0.30 SLC24A4
 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
 7376
 0.28
chr9_135897951_135898139 0.30 GTF3C5
 general transcription factor IIIC, polypeptide 5, 63kDa
 8031
 0.14
chr14_60693586_60693737 0.30 CTD-2184C24.2
18393
 0.19
chr19_42956472_42956792 0.30 LIPE-AS1
 LIPE antisense RNA 1
 8368
 0.12
chr2_213879689_213879840 0.30 AC079610.1
6505
 0.31
chr13_25202028_25202179 0.30 ENSG00000211508
 .
 18886
 0.18
chr14_54977048_54977291 0.30 CGRRF1
 cell growth regulator with ring finger domain 1
 545
 0.79
chr18_21582787_21583054 0.30 TTC39C
 tetratricopeptide repeat domain 39C
 10183
 0.18
chr3_50653123_50653503 0.29 MAPKAPK3
 mitogen-activated protein kinase-activated protein kinase 3
 1249
 0.38
chr10_11131193_11131344 0.29 CELF2-AS2
 CELF2 antisense RNA 2
 8855
 0.23
chr21_46047532_46047683 0.29 KRTAP10-9
 keratin associated protein 10-9
 567
 0.52
chr20_31056876_31057055 0.29 C20orf112
 chromosome 20 open reading frame 112
 14309
 0.17
chr11_94997219_94997453 0.29 RP11-712B9.2
31601
 0.19
chr12_93492296_93492447 0.29 ENSG00000221617
 .
 1344
 0.49
chr3_13021430_13021581 0.29 IQSEC1
 IQ motif and Sec7 domain 1
 7031
 0.28
chr7_155785095_155785246 0.29 AC021218.2
 Uncharacterized protein
 29844
 0.23
chr19_9946433_9946665 0.29 PIN1
 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
 532
 0.58
chr19_8400659_8400845 0.29 KANK3
 KN motif and ankyrin repeat domains 3
 7394
 0.1
chr1_226835966_226836117 0.29 ITPKB-IT1
 ITPKB intronic transcript 1 (non-protein coding)
 11330
 0.21
chr11_48018118_48018305 0.29 PTPRJ
 protein tyrosine phosphatase, receptor type, J
 15932
 0.19
chr12_89638036_89638195 0.29 ENSG00000238302
 .
 37947
 0.21
chr6_126230387_126230538 0.29 NCOA7
 nuclear receptor coactivator 7
 9407
 0.19
chr11_65552908_65553161 0.29 OVOL1
 ovo-like zinc finger 1
 1459
 0.22
chr12_105044364_105044605 0.29 ENSG00000264295
 .
 59073
 0.13
chr19_7929180_7929331 0.29 EVI5L
 ecotropic viral integration site 5-like
 3784
 0.1
chrX_12972828_12973236 0.28 TMSB4X
 thymosin beta 4, X-linked
 20195
 0.19
chr8_131020536_131020825 0.28 ENSG00000264653
 .
 19
 0.97
chr1_1827398_1827549 0.28 RP1-140A9.1
4563
 0.14
chr14_70165157_70165557 0.28 SRSF5
 serine/arginine-rich splicing factor 5
 28260
 0.2
chr15_77291917_77292573 0.28 PSTPIP1
 proline-serine-threonine phosphatase interacting protein 1
 4330
 0.22
chr16_17475953_17476212 0.28 XYLT1
 xylosyltransferase I
 88656
 0.11
chr20_1946593_1946814 0.28 RP4-684O24.5
18811
 0.19

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1 0.1 GO:0070669 response to interleukin-2(GO:0070669)
0.1 0.2 GO:0033004 negative regulation of mast cell activation(GO:0033004)
0.1 0.1 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 0.1 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.1 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:0072338 allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0 0.2 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.1 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.2 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.3 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0 0.2 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.0 GO:0070141 response to UV-A(GO:0070141)
0.0 0.2 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.2 GO:0043049 otic placode formation(GO:0043049)
0.0 0.1 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:1901985 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.1 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.2 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0 0.1 GO:0006565 L-serine catabolic process(GO:0006565)
0.0 0.0 GO:0070423 cytoplasmic pattern recognition receptor signaling pathway(GO:0002753) nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway(GO:0035872) nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.0 0.1 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.1 GO:0060157 urinary bladder development(GO:0060157)
0.0 0.5 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.2 GO:0002478 antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0 0.2 GO:0010452 histone H3-K36 methylation(GO:0010452)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0048537 mucosal-associated lymphoid tissue development(GO:0048537)
0.0 0.3 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 0.1 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.1 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.2 GO:2001021 negative regulation of response to DNA damage stimulus(GO:2001021)
0.0 0.1 GO:0035844 cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0 0.1 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.1 GO:0045048 protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.1 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.2 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.1 GO:0070570 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.1 GO:1903313 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.1 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.1 GO:0072033 renal vesicle formation(GO:0072033)
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.4 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 0.1 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.0 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.0 0.0 GO:0070244 negative regulation of thymocyte apoptotic process(GO:0070244)
0.0 0.2 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.6 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.0 0.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0046885 regulation of hormone biosynthetic process(GO:0046885)
0.0 0.1 GO:0002327 immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0 0.0 GO:0014874 response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.1 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
0.0 0.0 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.0 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 0.1 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
0.0 0.1 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.0 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.0 GO:0034135 regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.0 0.4 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.1 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0045007 depurination(GO:0045007)
0.0 0.0 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.1 GO:0045683 negative regulation of epidermal cell differentiation(GO:0045605) negative regulation of epidermis development(GO:0045683)
0.0 0.1 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 0.0 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0 0.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.0 GO:0033688 regulation of osteoblast proliferation(GO:0033688)
0.0 0.1 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.3 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.2 GO:0000085 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.0 0.1 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.0 GO:0051788 response to misfolded protein(GO:0051788)
0.0 0.0 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.0 GO:0002323 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0000239 pachytene(GO:0000239)
0.0 0.0 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.0 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0 0.1 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.1 GO:0031269 pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.0 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.0 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.1 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 0.0 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.0 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) membrane raft localization(GO:0051665)
0.0 0.4 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.1 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.2 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.0 GO:0043301 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0 0.1 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.1 GO:0042346 positive regulation of NF-kappaB import into nucleus(GO:0042346)
0.0 0.0 GO:0007100 mitotic centrosome separation(GO:0007100)
0.0 0.1 GO:0043029 T cell homeostasis(GO:0043029)
0.0 0.0 GO:0051446 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0 0.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.0 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.0 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.0 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.0 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.1 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.0 GO:0000154 rRNA modification(GO:0000154)
0.0 0.1 GO:0042094 interleukin-2 biosynthetic process(GO:0042094)
0.0 0.0 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.0 GO:0061384 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.0 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.3 GO:0006691 leukotriene metabolic process(GO:0006691)
0.0 0.0 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.0 GO:0018101 protein citrullination(GO:0018101)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.1 GO:0018065 protein-cofactor linkage(GO:0018065)
0.0 0.1 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.0 0.2 GO:0045576 mast cell activation(GO:0045576)
0.0 0.0 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.1 GO:0030238 male sex determination(GO:0030238)
0.0 0.1 GO:0001961 positive regulation of cytokine-mediated signaling pathway(GO:0001961)
0.0 0.1 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 0.0 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.0 0.1 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0 0.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.3 GO:0051318 G1 phase(GO:0051318)
0.0 0.1 GO:0006000 fructose metabolic process(GO:0006000)
0.0 0.1 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 0.0 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0 0.1 GO:0000303 response to superoxide(GO:0000303)
0.0 0.0 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.0 GO:0007506 gonadal mesoderm development(GO:0007506)
0.0 0.2 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.0 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.1 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.0 0.0 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.0 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.0 GO:0046101 hypoxanthine biosynthetic process(GO:0046101)
0.0 0.1 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.0 0.2 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0043218 compact myelin(GO:0043218)
0.1 0.5 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.2 GO:0001940 male pronucleus(GO:0001940)
0.1 0.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:0044462 external encapsulating structure part(GO:0044462)
0.0 0.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.3 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.1 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0031143 pseudopodium(GO:0031143)
0.0 0.0 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.1 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.0 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.0 GO:0002141 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.1 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.0 GO:0071437 invadopodium(GO:0071437)
0.0 0.1 GO:0000346 transcription export complex(GO:0000346)
0.0 0.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0000791 euchromatin(GO:0000791)
0.0 0.0 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 0.2 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.3 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.1 0.4 GO:0001727 lipid kinase activity(GO:0001727)
0.1 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.2 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0034190 apolipoprotein receptor binding(GO:0034190)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.4 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.2 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.0 0.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.5 GO:0070330 aromatase activity(GO:0070330)
0.0 0.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.4 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.1 GO:1901567 icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0 0.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.1 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.1 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0051766 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0 0.1 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0 0.1 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.2 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.2 GO:0005123 death receptor binding(GO:0005123)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.2 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.0 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.0 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.0 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.1 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.2 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.1 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.1 GO:0004396 hexokinase activity(GO:0004396)
0.0 0.1 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.0 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.0 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.0 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.0 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.0 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.1 GO:0016944 obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0 0.0 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.2 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.0 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.0 GO:0005035 death receptor activity(GO:0005035)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.0 GO:0070053 thrombospondin receptor activity(GO:0070053)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.4 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.0 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.0 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.6 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.7 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.5 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.0 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.3 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.4 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.0 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.0 0.2 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.7 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.3 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.0 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.0 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.1 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.0 REACTOME SIGNAL AMPLIFICATION Genes involved in Signal amplification
0.0 0.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.1 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.1 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.1 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.3 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC