CREMA results: ZKSCAN3

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Transcription factors associated with ZKSCAN3

Gene Symbol	Gene ID	Gene Info
ZKSCAN3 Ensembl NCBI GeneCards UniProt	ENSG00000189298.9	zinc finger with KRAB and SCAN domains 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr6_28317244_28317413	ZKSCAN3	363	0.828791	0.27	4.8e-01	Click!
chr6_28317523_28317674	ZKSCAN3	93	0.958716	0.05	8.9e-01	Click!
chr6_28318026_28318177	ZKSCAN3	374	0.819170	0.44	2.3e-01	Click!
chr6_28318404_28318713	ZKSCAN3	831	0.531891	0.66	5.5e-02	Click!
chr6_28318919_28319190	ZKSCAN3	1327	0.348212	0.54	1.3e-01	Click!

Showing 1 to 5 of 5 entries

Activity of the ZKSCAN3 motif across conditions

Conditions sorted by the z-value of the ZKSCAN3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_14610353_14610666	2.07	FAM107B	family with sequence similarity 107, member B	3520	0.31
chr9_100866127_100866462	1.53	TRIM14	tripartite motif containing 14	11451	0.18
chr11_64013353_64013610	0.94	RP11-783K16.5		45	0.65
chr1_211509622_211509899	0.92	TRAF5	TNF receptor-associated factor 5	9581	0.25
chr1_26100660_26100867	0.85	SEPN1	selenoprotein N, 1	25904	0.11
chr14_50563249_50563678	0.81	C14orf183	chromosome 14 open reading frame 183	4102	0.18
chr8_37748769_37748986	0.79	RAB11FIP1	RAB11 family interacting protein 1 (class I)	8095	0.14
chr4_100766407_100766703	0.79	DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides	28552	0.18
chr14_93159663_93159814	0.78	LGMN	legumain	24066	0.21
chr1_92940802_92940965	0.78	GFI1	growth factor independent 1 transcription repressor	8628	0.26

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.5	GO:0010324	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.5	GO:0000303	response to superoxide(GO:0000303)
0.1	0.4	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.1	0.4	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1	0.4	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.4	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0	0.4	GO:0001522	pseudouridine synthesis(GO:0001522)
0.0	0.4	GO:0006749	glutathione metabolic process(GO:0006749)
0.0	0.4	GO:0006888	ER to Golgi vesicle-mediated transport(GO:0006888)

Showing 1 to 10 of 121 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.4	GO:0035631	CD40 receptor complex(GO:0035631)
0.1	0.3	GO:0000800	lateral element(GO:0000800)
0.0	0.3	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.3	GO:0017119	Golgi transport complex(GO:0017119)
0.1	0.2	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.1	0.2	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.2	GO:0070820	tertiary granule(GO:0070820)
0.0	0.2	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.2	GO:0048188	Set1C/COMPASS complex(GO:0048188)

Showing 1 to 10 of 40 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0	0.5	GO:0003743	translation initiation factor activity(GO:0003743)
0.1	0.4	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.4	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	0.4	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.4	GO:0004879	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0	0.3	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.3	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.3	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.3	GO:0019212	phosphatase inhibitor activity(GO:0019212)

Showing 1 to 10 of 99 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.8	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.5	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.5	PID REELIN PATHWAY	Reelin signaling pathway
0.5	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.4	PID IL27 PATHWAY	IL27-mediated signaling events
0.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.4	PID TNF PATHWAY	TNF receptor signaling pathway
0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.3	ST GA12 PATHWAY	G alpha 12 Pathway
0.3	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway

Showing 1 to 10 of 19 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.7	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.6	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.5	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.4	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.3	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.3	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.3	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.2	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling

Showing 1 to 10 of 28 entries

Results for ZKSCAN3

Z-value: 1.44

Motif logo

Transcription factors associated with ZKSCAN3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the ZKSCAN3 motif across conditions

Conditions sorted by the z-value of the ZKSCAN3 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: