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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for ZKSCAN3

Z-value: 1.44

Motif logo

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Transcription factors associated with ZKSCAN3

Gene Symbol Gene ID Gene Info
ZKSCAN3
ENSG00000189298.9 zinc finger with KRAB and SCAN domains 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr6_28318404_28318713ZKSCAN38310.5318910.665.5e-02Click!
chr6_28318919_28319190ZKSCAN313270.3482120.541.3e-01Click!
chr6_28318026_28318177ZKSCAN33740.8191700.442.3e-01Click!
chr6_28317244_28317413ZKSCAN33630.8287910.274.8e-01Click!
chr6_28317523_28317674ZKSCAN3930.9587160.058.9e-01Click!

Activity of the ZKSCAN3 motif across conditions

Conditions sorted by the z-value of the ZKSCAN3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr10_14610353_14610666 2.07 FAM107B
 family with sequence similarity 107, member B
 3520
 0.31
chr9_100866127_100866462 1.53 TRIM14
 tripartite motif containing 14
 11451
 0.18
chr11_64013353_64013610 0.94 RP11-783K16.5
45
 0.65
chr1_211509622_211509899 0.92 TRAF5
 TNF receptor-associated factor 5
 9581
 0.25
chr1_26100660_26100867 0.85 SEPN1
 selenoprotein N, 1
 25904
 0.11
chr14_50563249_50563678 0.81 C14orf183
 chromosome 14 open reading frame 183
 4102
 0.18
chr8_37748769_37748986 0.79 RAB11FIP1
 RAB11 family interacting protein 1 (class I)
 8095
 0.14
chr4_100766407_100766703 0.79 DAPP1
 dual adaptor of phosphotyrosine and 3-phosphoinositides
 28552
 0.18
chr14_93159663_93159814 0.78 LGMN
 legumain
 24066
 0.21
chr1_92940802_92940965 0.78 GFI1
 growth factor independent 1 transcription repressor
 8628
 0.26
chr2_227702908_227703080 0.70 RHBDD1
 rhomboid domain containing 1
 730
 0.71
chr1_25361714_25361887 0.70 ENSG00000264371
 .
 11806
 0.23
chr16_57056402_57056553 0.69 NLRC5
 NLR family, CARD domain containing 5
 1852
 0.27
chr2_97167178_97167382 0.69 NEURL3
 neuralized E3 ubiquitin protein ligase 3
 619
 0.73
chr20_4789979_4790248 0.68 RASSF2
 Ras association (RalGDS/AF-6) domain family member 2
 5656
 0.22
chr20_56193901_56194158 0.67 ZBP1
 Z-DNA binding protein 1
 1421
 0.48
chr1_211526157_211526486 0.67 TRAF5
 TNF receptor-associated factor 5
 6615
 0.27
chr11_73680269_73680439 0.66 RP11-167N4.2
978
 0.46
chr15_60688686_60688869 0.65 ANXA2
 annexin A2
 760
 0.75
chr15_64720015_64720166 0.65 TRIP4
 thyroid hormone receptor interactor 4
 3776
 0.14
chr9_135363597_135363846 0.64 ENSG00000252521
 .
 66693
 0.1
chr22_40327971_40328220 0.63 GRAP2
 GRB2-related adaptor protein 2
 5454
 0.19
chr17_71589495_71589717 0.62 RP11-277J6.2
47559
 0.14
chr11_73684050_73684451 0.62 RP11-167N4.2
2918
 0.19
chr12_14577482_14577735 0.62 ATF7IP
 activating transcription factor 7 interacting protein
 913
 0.66
chr10_15009390_15009541 0.61 MEIG1
 meiosis/spermiogenesis associated 1
 1027
 0.53
chr2_136891083_136891299 0.61 CXCR4
 chemokine (C-X-C motif) receptor 4
 15456
 0.27
chr19_682192_682343 0.61 FSTL3
 follistatin-like 3 (secreted glycoprotein)
 4325
 0.11
chr14_99678734_99678885 0.61 AL109767.1
50476
 0.13
chr4_89517359_89517510 0.58 HERC3
 HECT and RLD domain containing E3 ubiquitin protein ligase 3
 2905
 0.24
chr11_73095605_73095891 0.58 RELT
 RELT tumor necrosis factor receptor
 8035
 0.15
chr5_118607191_118607349 0.58 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 2821
 0.26
chr3_9821453_9821979 0.58 CAMK1
 calcium/calmodulin-dependent protein kinase I
 10040
 0.09
chr1_101749629_101749820 0.57 RP4-575N6.5
41010
 0.13
chr1_67727636_67727815 0.57 ENSG00000252116
 .
 5684
 0.17
chr7_150178587_150178758 0.56 GIMAP8
 GTPase, IMAP family member 8
 30954
 0.13
chr15_28382300_28382484 0.56 HERC2
 HECT and RLD domain containing E3 ubiquitin protein ligase 2
 37177
 0.18
chr3_185313043_185313423 0.56 SENP2
 SUMO1/sentrin/SMT3 specific peptidase 2
 9150
 0.23
chr1_26873022_26873700 0.56 RPS6KA1
 ribosomal protein S6 kinase, 90kDa, polypeptide 1
 1018
 0.45
chr9_137039448_137039599 0.56 ENSG00000221676
 .
 9837
 0.2
chr6_112133106_112133257 0.55 FYN
 FYN oncogene related to SRC, FGR, YES
 8100
 0.29
chr13_30950886_30951061 0.55 KATNAL1
 katanin p60 subunit A-like 1
 69352
 0.11
chr3_15503071_15503367 0.55 EAF1-AS1
 EAF1 antisense RNA 1
 10110
 0.12
chr17_60872822_60872973 0.55 MARCH10
 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
 11104
 0.24
chr7_37382804_37383115 0.55 ELMO1
 engulfment and cell motility 1
 176
 0.96
chr9_139423606_139423897 0.54 ENSG00000263403
 .
 9673
 0.09
chr19_7702843_7703102 0.53 STXBP2
 syntaxin binding protein 2
 959
 0.26
chr15_55514367_55514559 0.53 RSL24D1
 ribosomal L24 domain containing 1
 25198
 0.18
chr14_61831663_61831831 0.53 PRKCH
 protein kinase C, eta
 3955
 0.27
chr15_31134475_31134626 0.53 ENSG00000221379
 .
 41041
 0.12
chr14_56582946_56583243 0.52 PELI2
 pellino E3 ubiquitin protein ligase family member 2
 1438
 0.49
chr14_35303784_35304022 0.52 ENSG00000251726
 .
 10663
 0.17
chr2_241562052_241562405 0.52 GPR35
 G protein-coupled receptor 35
 2434
 0.21
chr11_44631349_44631561 0.52 RP11-58K22.4
1804
 0.34
chr9_20378989_20379416 0.51 MLLT3
 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
 3265
 0.26
chr20_8116239_8116390 0.51 PLCB1
 phospholipase C, beta 1 (phosphoinositide-specific)
 3012
 0.36
chr15_64260424_64260713 0.51 RP11-111E14.1
40095
 0.15
chr9_129159177_129159360 0.50 ENSG00000253079
 .
 11421
 0.2
chr14_77234089_77234240 0.50 VASH1
 vasohibin 1
 5492
 0.2
chr20_55059757_55060025 0.49 ENSG00000238294
 .
 9192
 0.13
chr13_41576048_41576351 0.49 ELF1
 E74-like factor 1 (ets domain transcription factor)
 17251
 0.19
chr19_6766080_6766650 0.49 SH2D3A
 SH2 domain containing 3A
 1081
 0.38
chr3_170942262_170942413 0.49 TNIK
 TRAF2 and NCK interacting kinase
 1163
 0.63
chrX_53740602_53740909 0.49 HUWE1
 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
 27082
 0.23
chr19_39728024_39728175 0.48 IFNL3
 interferon, lambda 3
 7547
 0.12
chr3_183259605_183259756 0.48 KLHL6-AS1
 KLHL6 antisense RNA 1
 6843
 0.17
chr12_57865222_57865373 0.48 ARHGAP9
 Rho GTPase activating protein 9
 3420
 0.1
chr14_34512264_34512415 0.48 EGLN3-AS1
 EGLN3 antisense RNA 1
 3036
 0.35
chr17_7779861_7780054 0.47 CHD3
 chromodomain helicase DNA binding protein 3
 8167
 0.09
chr14_89977838_89978024 0.47 FOXN3
 forkhead box N3
 17402
 0.19
chr4_6916161_6916458 0.46 TBC1D14
 TBC1 domain family, member 14
 4334
 0.22
chr7_4748966_4749117 0.46 ENSG00000238781
 .
 19930
 0.18
chr17_42326114_42326265 0.46 AC003102.1
1047
 0.29
chr2_39472617_39472990 0.46 CDKL4
 cyclin-dependent kinase-like 4
 16130
 0.19
chr2_118771117_118771268 0.46 CCDC93
 coiled-coil domain containing 93
 517
 0.7
chr8_818924_819075 0.46 ERICH1-AS1
 ERICH1 antisense RNA 1
 14199
 0.29
chr5_14587040_14587260 0.45 FAM105A
 family with sequence similarity 105, member A
 5266
 0.28
chr21_47335720_47335871 0.45 PRED62
 Uncharacterized protein
 16682
 0.18
chr20_1677648_1677799 0.45 ENSG00000242348
 .
 30717
 0.14
chr3_122512892_122513151 0.45 HSPBAP1
 HSPB (heat shock 27kDa) associated protein 1
 350
 0.67
chr17_17209430_17209581 0.45 NT5M
 5',3'-nucleotidase, mitochondrial
 2856
 0.24
chr3_52267134_52267345 0.45 TLR9
 TLR9
 2033
 0.17
chr11_35073040_35073191 0.45 PDHX
 pyruvate dehydrogenase complex, component X
 73784
 0.08
chr14_22886920_22887071 0.44 ENSG00000251002
 .
 14724
 0.12
chr21_47971487_47971638 0.44 ENSG00000272283
 .
 15853
 0.17
chr7_138777169_138777799 0.44 ZC3HAV1
 zinc finger CCCH-type, antiviral 1
 13471
 0.2
chr1_1148836_1149071 0.44 TNFRSF4
 tumor necrosis factor receptor superfamily, member 4
 559
 0.53
chr18_13313200_13313369 0.44 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
 35182
 0.14
chr9_34122816_34123204 0.44 DCAF12
 DDB1 and CUL4 associated factor 12
 2715
 0.22
chr18_21601039_21601542 0.43 TTC39C
 tetratricopeptide repeat domain 39C
 4692
 0.2
chr1_65408943_65409111 0.43 JAK1
 Janus kinase 1
 23160
 0.22
chr1_160654931_160655551 0.43 RP11-404F10.2
11929
 0.15
chr21_34561335_34561486 0.43 C21orf54
 chromosome 21 open reading frame 54
 18869
 0.14
chr4_2837699_2838048 0.43 ADD1
 adducin 1 (alpha)
 7711
 0.2
chr15_60883775_60883968 0.43 RORA
 RAR-related orphan receptor A
 869
 0.66
chr12_62998741_62998934 0.43 ENSG00000199179
 .
 1371
 0.28
chr1_205884511_205884662 0.43 RP4-681L3.2
19670
 0.17
chr1_67426336_67426573 0.43 MIER1
 mesoderm induction early response 1, transcriptional regulator
 30528
 0.16
chr21_36391287_36391723 0.43 RUNX1
 runt-related transcription factor 1
 29957
 0.26
chr5_56025506_56025889 0.42 MAP3K1
 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
 85704
 0.08
chr19_19630373_19630524 0.42 NDUFA13
 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
 3409
 0.12
chr1_89667140_89667505 0.42 GBP4
 guanylate binding protein 4
 2707
 0.26
chr4_6918676_6918943 0.42 TBC1D14
 TBC1 domain family, member 14
 6834
 0.19
chr1_98380116_98380267 0.41 DPYD
 dihydropyrimidine dehydrogenase
 6362
 0.32
chr5_11234617_11234797 0.41 ENSG00000207312
 .
 207395
 0.03
chr7_134852339_134852490 0.41 RP11-134L10.1
741
 0.55
chr16_25077360_25077511 0.41 LCMT1
 leucine carboxyl methyltransferase 1
 45615
 0.14
chr17_2236873_2237024 0.41 TSR1
 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
 2803
 0.13
chr22_21960363_21960532 0.41 YDJC
 YdjC homolog (bacterial)
 23878
 0.08
chr15_66065362_66065523 0.40 RP11-16E23.3
5706
 0.18
chr13_42895024_42895175 0.40 AKAP11
 A kinase (PRKA) anchor protein 11
 48810
 0.18
chr1_231171258_231171409 0.40 FAM89A
 family with sequence similarity 89, member A
 4659
 0.18
chr1_12242763_12243127 0.40 ENSG00000263676
 .
 8825
 0.16
chr12_7063873_7064421 0.40 PTPN6
 protein tyrosine phosphatase, non-receptor type 6
 3609
 0.07
chr20_58515754_58515905 0.40 FAM217B
 family with sequence similarity 217, member B
 335
 0.59
chr13_99952051_99952321 0.40 GPR183
 G protein-coupled receptor 183
 7473
 0.21
chr1_206809391_206809612 0.40 DYRK3
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
 327
 0.63
chr17_58041513_58041664 0.40 RNFT1
 ring finger protein, transmembrane 1
 492
 0.75
chr9_97429931_97430112 0.40 FBP1
 fructose-1,6-bisphosphatase 1
 27490
 0.19
chr3_43236741_43236892 0.39 ENSG00000222331
 .
 15547
 0.22
chr1_175166883_175167095 0.39 KIAA0040
 KIAA0040
 4910
 0.3
chr9_114426841_114427100 0.39 GNG10
 guanine nucleotide binding protein (G protein), gamma 10
 3355
 0.21
chr17_44218651_44218858 0.39 ENSG00000252698
 .
 13992
 0.17
chr2_205834532_205835011 0.38 PARD3B
 par-3 family cell polarity regulator beta
 424048
 0.01
chr9_126763063_126763261 0.38 LHX2
 LIM homeobox 2
 787
 0.6
chr11_117198965_117199116 0.38 CEP164
 centrosomal protein 164kDa
 221
 0.57
chrX_153231291_153231484 0.38 HCFC1-AS1
 HCFC1 antisense RNA 1
 3389
 0.11
chr15_42181166_42181317 0.38 RP11-23P13.6
3750
 0.13
chr15_60828599_60828948 0.38 CTD-2501E16.2
6601
 0.21
chr17_56361902_56362063 0.38 MPO
 myeloperoxidase
 3686
 0.16
chr15_30456809_30456986 0.38 ENSG00000221785
 .
 19817
 0.12
chr11_32610462_32610653 0.38 EIF3M
 eukaryotic translation initiation factor 3, subunit M
 575
 0.82
chr11_1606465_1606821 0.37 KRTAP5-1
 keratin associated protein 5-1
 130
 0.93
chr1_47181224_47181375 0.37 EFCAB14
 EF-hand calcium binding domain 14
 3437
 0.21
chr7_96651846_96652002 0.37 DLX5
 distal-less homeobox 5
 2338
 0.25
chr1_35897155_35897306 0.37 ENSG00000202129
 .
 3736
 0.22
chr8_53851916_53852182 0.37 NPBWR1
 neuropeptides B/W receptor 1
 1058
 0.63
chr5_171061383_171061534 0.37 ENSG00000264303
 .
 136076
 0.04
chr6_35653753_35653924 0.37 FKBP5
 FK506 binding protein 5
 2854
 0.19
chr4_16124268_16124434 0.36 PROM1
 prominin 1
 38350
 0.16
chr3_59995792_59996170 0.36 NPCDR1
 nasopharyngeal carcinoma, down-regulated 1
 38398
 0.24
chr15_32665699_32665938 0.36 ENSG00000221444
 .
 19855
 0.11
chr19_4638499_4638663 0.36 TNFAIP8L1
 tumor necrosis factor, alpha-induced protein 8-like 1
 949
 0.43
chr6_24918083_24918272 0.36 FAM65B
 family with sequence similarity 65, member B
 6982
 0.24
chr3_9440127_9440389 0.36 SETD5-AS1
 SETD5 antisense RNA 1
 5
 0.93
chr3_9885266_9885439 0.36 RPUSD3
 RNA pseudouridylate synthase domain containing 3
 274
 0.82
chr20_35573807_35573970 0.36 SAMHD1
 SAM domain and HD domain 1
 6223
 0.23
chr20_30607376_30607540 0.35 CCM2L
 cerebral cavernous malformation 2-like
 437
 0.74
chr2_65295203_65295373 0.35 CEP68
 centrosomal protein 68kDa
 11689
 0.17
chr15_30472324_30472499 0.35 ENSG00000221785
 .
 35331
 0.11
chr1_90206501_90206652 0.35 ENSG00000239176
 .
 27301
 0.18
chr10_32216291_32216562 0.35 ARHGAP12
 Rho GTPase activating protein 12
 1302
 0.55
chr7_142500079_142500230 0.35 PRSS3P2
 protease, serine, 3 pseudogene 2
 19023
 0.16
chr2_106394710_106394861 0.34 NCK2
 NCK adaptor protein 2
 32597
 0.22
chr2_161945197_161945348 0.34 TANK
 TRAF family member-associated NFKB activator
 48147
 0.16
chr17_56394632_56394843 0.34 BZRAP1
 benzodiazepine receptor (peripheral) associated protein 1
 6636
 0.12
chr6_149794191_149794357 0.34 ZC3H12D
 zinc finger CCCH-type containing 12D
 9995
 0.17
chr21_43948338_43948579 0.34 SLC37A1
 solute carrier family 37 (glucose-6-phosphate transporter), member 1
 13824
 0.13
chr11_114030278_114030531 0.34 ENSG00000221112
 .
 72753
 0.1
chr11_125461625_125461796 0.33 STT3A
 STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
 103
 0.9
chr18_8602838_8602989 0.33 RAB12
 RAB12, member RAS oncogene family
 6530
 0.22
chr9_34981335_34981528 0.33 DNAJB5
 DnaJ (Hsp40) homolog, subfamily B, member 5
 8207
 0.15
chr6_15399373_15399540 0.33 JARID2
 jumonji, AT rich interactive domain 2
 1633
 0.48
chr2_240673435_240673899 0.33 AC093802.1
 Uncharacterized protein
 10887
 0.29
chr2_61243941_61244148 0.33 PUS10
 pseudouridylate synthase 10
 284
 0.51
chr19_21646642_21646886 0.33 ZNF429
 zinc finger protein 429
 41602
 0.16
chr1_27686480_27686799 0.33 MAP3K6
 mitogen-activated protein kinase kinase kinase 6
 3677
 0.14
chrX_43295883_43296068 0.33 MAOA
 monoamine oxidase A
 219492
 0.02
chr12_53024160_53024311 0.33 KRT73
 keratin 73
 11892
 0.11
chr2_103036026_103036177 0.33 IL18RAP
 interleukin 18 receptor accessory protein
 45
 0.97
chr1_26635107_26635385 0.33 UBXN11
 UBX domain protein 11
 1766
 0.23
chr16_75123794_75123945 0.33 ZNRF1
 zinc and ring finger 1, E3 ubiquitin protein ligase
 14813
 0.15
chr4_78079689_78079921 0.33 CCNG2
 cyclin G2
 226
 0.94
chr12_12028552_12028703 0.33 ETV6
 ets variant 6
 10244
 0.3
chr3_5047856_5048016 0.33 BHLHE40-AS1
 BHLHE40 antisense RNA 1
 26290
 0.17
chr18_2884812_2884995 0.33 RP11-737O24.5
36061
 0.12
chr7_110650904_110651055 0.32 LRRN3
 leucine rich repeat neuronal 3
 80083
 0.1
chr19_2701835_2702122 0.32 GNG7
 guanine nucleotide binding protein (G protein), gamma 7
 729
 0.53
chr9_36666940_36667091 0.32 MELK
 maternal embryonic leucine zipper kinase
 94107
 0.08
chr20_47365648_47365892 0.32 ENSG00000251876
 .
 9785
 0.28
chr2_234150632_234150905 0.32 ATG16L1
 autophagy related 16-like 1 (S. cerevisiae)
 9449
 0.15
chr2_43382252_43382437 0.32 ENSG00000207087
 .
 63712
 0.12
chr8_144075541_144075692 0.32 LY6E
 lymphocyte antigen 6 complex, locus E
 23783
 0.15
chr16_23464322_23464473 0.32 COG7
 component of oligomeric golgi complex 7
 104
 0.95
chrX_147701487_147701638 0.32 AFF2-IT1
 AFF2 intronic transcript 1 (non-protein coding)
 73163
 0.11
chr19_12936277_12936463 0.32 CTD-2265O21.3
155
 0.86
chr1_161097729_161097968 0.32 DEDD
 death effector domain containing
 2779
 0.1
chr20_19918143_19918294 0.32 RIN2
 Ras and Rab interactor 2
 48008
 0.15
chr3_52331644_52331795 0.32 ENSG00000242797
 .
 1211
 0.27
chr2_111610296_111610719 0.31 ACOXL
 acyl-CoA oxidase-like
 47611
 0.18
chr6_157304957_157305108 0.31 ARID1B
 AT rich interactive domain 1B (SWI1-like)
 82525
 0.11
chr14_89925929_89926200 0.31 FOXN3
 forkhead box N3
 34331
 0.15
chr19_30557968_30558119 0.31 URI1
 URI1, prefoldin-like chaperone
 54713
 0.17
chr12_117534939_117535195 0.31 TESC
 tescalcin
 2184
 0.41
chr16_3554613_3554882 0.31 CLUAP1
 clusterin associated protein 1
 2703
 0.18
chr7_143005618_143005769 0.31 CLCN1
 chloride channel, voltage-sensitive 1
 7526
 0.1
chr14_107198967_107199211 0.31 IGHV3-72
 immunoglobulin heavy variable 3-72
 382
 0.58
chr14_23018397_23018864 0.31 AE000662.92
 Uncharacterized protein
 6904
 0.11
chr2_98347856_98348007 0.31 ZAP70
 zeta-chain (TCR) associated protein kinase 70kDa
 2938
 0.25
chr6_167508030_167508365 0.31 CCR6
 chemokine (C-C motif) receptor 6
 17098
 0.18

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 0.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 0.4 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 0.2 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1 0.2 GO:0070672 response to interleukin-15(GO:0070672)
0.1 0.2 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.1 0.3 GO:0051024 positive regulation of immunoglobulin secretion(GO:0051024)
0.1 0.2 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.1 0.2 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.1 0.2 GO:1901534 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.1 0.2 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.3 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 0.5 GO:0010324 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.5 GO:0000303 response to superoxide(GO:0000303)
0.0 0.1 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.1 GO:0002323 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.0 0.2 GO:0009103 lipopolysaccharide biosynthetic process(GO:0009103)
0.0 0.1 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.2 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.1 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.4 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.1 GO:0021780 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0 0.1 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.1 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.4 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.1 GO:0009129 pyrimidine nucleoside monophosphate metabolic process(GO:0009129)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.1 GO:2000328 T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) memory T cell differentiation(GO:0043379) regulation of memory T cell differentiation(GO:0043380) positive regulation of memory T cell differentiation(GO:0043382) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540) regulation of T-helper 17 type immune response(GO:2000316) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 17 cell differentiation(GO:2000319) positive regulation of T-helper 17 cell differentiation(GO:2000321) regulation of T-helper 17 cell lineage commitment(GO:2000328) positive regulation of T-helper 17 cell lineage commitment(GO:2000330)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.2 GO:0031000 response to caffeine(GO:0031000)
0.0 0.1 GO:0001866 NK T cell proliferation(GO:0001866)
0.0 0.1 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.2 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.2 GO:0007141 male meiosis I(GO:0007141)
0.0 0.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0060433 bronchus development(GO:0060433)
0.0 0.2 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.2 GO:0051597 response to methylmercury(GO:0051597)
0.0 0.2 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0 0.1 GO:2000008 regulation of protein localization to cell surface(GO:2000008)
0.0 0.1 GO:0003161 cardiac conduction system development(GO:0003161)
0.0 0.1 GO:0043324 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0 0.0 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.2 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0051974 negative regulation of telomerase activity(GO:0051974)
0.0 0.1 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.1 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.1 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.2 GO:0051319 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.1 GO:0031065 regulation of histone deacetylation(GO:0031063) positive regulation of histone deacetylation(GO:0031065)
0.0 0.2 GO:0050860 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.0 GO:1904019 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.0 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.0 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.0 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.1 GO:0002691 regulation of cellular extravasation(GO:0002691)
0.0 0.1 GO:0051299 centrosome separation(GO:0051299)
0.0 0.0 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.1 GO:0032402 melanosome transport(GO:0032402)
0.0 0.1 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.0 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.0 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.0 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.2 GO:0044409 entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0 0.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.0 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.1 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 0.1 GO:0001885 endothelial cell development(GO:0001885)
0.0 0.0 GO:0060685 regulation of prostatic bud formation(GO:0060685)
0.0 0.1 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.1 GO:0006000 fructose metabolic process(GO:0006000)
0.0 0.2 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 0.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.0 GO:2000192 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0 0.0 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.1 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.1 GO:0032367 intracellular sterol transport(GO:0032366) intracellular cholesterol transport(GO:0032367)
0.0 0.0 GO:0009191 nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.0 GO:0051461 corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0 0.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.0 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.0 GO:0040009 regulation of growth rate(GO:0040009)
0.0 0.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0045446 endothelial cell differentiation(GO:0045446)
0.0 0.0 GO:0046101 hypoxanthine biosynthetic process(GO:0046101)
0.0 0.6 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.1 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.2 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.1 GO:0030101 natural killer cell activation(GO:0030101)
0.0 0.1 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.0 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448)
0.0 0.0 GO:0033261 obsolete regulation of S phase(GO:0033261)
0.0 0.1 GO:0006069 ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0 0.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.0 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0000800 lateral element(GO:0000800)
0.1 0.2 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.1 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.2 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0070820 tertiary granule(GO:0070820)
0.0 0.4 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0002142 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.1 GO:0032009 early phagosome(GO:0032009)
0.0 0.1 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 0.1 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.0 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.1 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.0 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 0.2 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1 0.2 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.2 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.8 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.3 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.2 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.1 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.1 GO:0002060 purine nucleobase binding(GO:0002060)
0.0 0.1 GO:0015137 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0035197 siRNA binding(GO:0035197)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.2 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0005497 androgen binding(GO:0005497)
0.0 0.1 GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.0 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.1 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.0 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.0 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.1 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.0 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.1 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.0 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.3 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 0.1 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 0.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.0 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.0 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.0 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0046625 sphingolipid binding(GO:0046625)
0.0 0.2 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.0 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.0 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.0 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.0 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.1 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.1 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.0 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.4 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.1 GO:0051998 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0 0.3 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.0 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.0 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.0 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.0 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.0 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.5 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.3 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.3 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.4 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.2 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.3 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.4 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.3 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.6 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.5 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.7 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.4 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.2 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.1 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.2 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.0 REACTOME BILE ACID AND BILE SALT METABOLISM Genes involved in Bile acid and bile salt metabolism
0.0 0.0 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0 0.0 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.0 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.1 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.0 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.2 REACTOME CD28 CO STIMULATION Genes involved in CD28 co-stimulation
0.0 0.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.1 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage