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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZNF274

Z-value: 1.31

Motif logo

Transcription factors associated with ZNF274

Gene Symbol	Gene ID	Gene Info
ZNF274 Ensembl NCBI GeneCards UniProt	ENSG00000171606.13	ZNF274

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZNF274	chr19_58693943_58694152	349	0.824205	-0.56	1.2e-01	Click!
ZNF274	chr19_58694466_58694617	145	0.938271	-0.47	2.1e-01	Click!
ZNF274	chr19_58695110_58695333	358	0.817942	-0.41	2.7e-01	Click!
ZNF274	chr19_58693650_58693919	612	0.642528	-0.33	3.9e-01	Click!
ZNF274	chr19_58695365_58695593	616	0.639644	-0.26	4.9e-01	Click!

Activity of the ZNF274 motif across conditions

Conditions sorted by the z-value of the ZNF274 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr16_89365642_89366074	2.42	AC137932.5		1594	0.28
chr19_58868146_58868568	1.44	CTD-2619J13.9		1008	0.25
chr16_89366119_89366411	1.03	AC137932.5		2001	0.23
chr2_242680975_242681169	0.88	D2HGDH	D-2-hydroxyglutarate dehydrogenase	776	0.45
chr7_148767712_148767863	0.78	ZNF786	zinc finger protein 786	20010	0.12
chr20_24962486_24962637	0.66	ENSG00000207355	.	7754	0.18
chr3_15316866_15317185	0.62	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	391	0.81
chr17_27068859_27069066	0.57	AC010761.6		821	0.26
chr7_81396029_81396416	0.57	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	3065	0.4
chr1_6041214_6041365	0.56	KCNAB2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	10237	0.18
chr20_418602_419173	0.56	ENSG00000206797	.	12420	0.15
chr11_48037642_48037830	0.55	AC103828.1		329	0.9
chr6_6726794_6727009	0.55	LY86-AS1	LY86 antisense RNA 1	103897	0.08
chr7_140058154_140058347	0.55	SLC37A3	solute carrier family 37, member 3	6350	0.15
chr5_169708109_169708260	0.54	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	13853	0.22
chr4_88313270_88313528	0.54	HSD17B11	hydroxysteroid (17-beta) dehydrogenase 11	861	0.54
chr15_90480001_90480190	0.54	C15orf38	chromosome 15 open reading frame 38	23907	0.1
chr11_122939463_122939751	0.53	HSPA8	heat shock 70kDa protein 8	5669	0.16
chr20_25655869_25656020	0.53	ZNF337	zinc finger protein 337	11402	0.16
chr1_10461491_10461642	0.53	PGD	phosphogluconate dehydrogenase	1877	0.22
chr3_13050536_13050725	0.52	IQSEC1	IQ motif and Sec7 domain 1	22094	0.24
chr14_35400530_35400841	0.51	ENSG00000199980	.	2064	0.3
chr13_24852090_24852325	0.51	SPATA13	spermatogenesis associated 13	5380	0.18
chrX_153214056_153214561	0.50	RENBP	renin binding protein	4076	0.1
chr11_10765370_10765523	0.49	CTR9	CTR9, Paf1/RNA polymerase II complex component	7088	0.15
chr13_29156493_29156762	0.49	POMP	proteasome maturation protein	76614	0.1
chr16_1538550_1538777	0.48	PTX4	pentraxin 4, long	195	0.86
chr14_91874860_91875123	0.48	CCDC88C	coiled-coil domain containing 88C	8699	0.24
chr9_92316642_92316885	0.47	GADD45G	growth arrest and DNA-damage-inducible, gamma	96810	0.09
chr10_104197193_104197463	0.47	ENSG00000202569	.	1059	0.32
chr14_91817459_91817741	0.46	ENSG00000265856	.	17543	0.21
chr5_58568933_58569140	0.46	PDE4D	phosphodiesterase 4D, cAMP-specific	2909	0.42
chr19_51919928_51920449	0.45	SIGLEC10	sialic acid binding Ig-like lectin 10	647	0.4
chr13_25200724_25201013	0.45	ENSG00000211508	.	17651	0.18
chr16_87076415_87076642	0.45	RP11-899L11.3		172993	0.03
chr21_36384069_36384311	0.45	RUNX1	runt-related transcription factor 1	37272	0.23
chr3_176784016_176784245	0.45	TBL1XR1-AS1	TBL1XR1 antisense RNA 1	21481	0.22
chr1_25782884_25783035	0.45	TMEM57	transmembrane protein 57	25548	0.14
chr13_98396488_98396639	0.44	ENSG00000238407	.	141500	0.05
chr12_117033216_117033367	0.44	MAP1LC3B2	microtubule-associated protein 1 light chain 3 beta 2	19635	0.25
chr4_185772755_185773053	0.44	ENSG00000266698	.	640	0.72
chr4_26385783_26386117	0.44	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	21798	0.26
chrX_37684198_37684679	0.44	DYNLT3	dynein, light chain, Tctex-type 3	22223	0.19
chr13_111173056_111173211	0.44	COL4A2-AS1	COL4A2 antisense RNA 1	12607	0.2
chr18_55334626_55334855	0.43	ATP8B1	ATPase, aminophospholipid transporter, class I, type 8B, member 1	21160	0.15
chr3_71760476_71760839	0.43	EIF4E3	eukaryotic translation initiation factor 4E family member 3	13869	0.22
chrX_1590509_1590809	0.43	ASMTL	acetylserotonin O-methyltransferase-like	18004	0.18
chrY_1540506_1540807	0.42	NA	NA	> 10⁶	NA
chr4_124399364_124399515	0.42	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	78316	0.12
chr1_65472844_65472995	0.42	ENSG00000212257	.	15838	0.19
chr12_11963905_11964056	0.42	ETV6	ets variant 6	58545	0.15
chr11_67179086_67179395	0.42	CARNS1	carnosine synthase 1	3909	0.08
chr2_223485669_223485820	0.42	FARSB	phenylalanyl-tRNA synthetase, beta subunit	35026	0.15
chr9_140171055_140171601	0.42	TOR4A	torsin family 4, member A	873	0.34
chr5_64318013_64318164	0.41	ENSG00000207439	.	101108	0.08
chr1_226985906_226986297	0.41	ITPKB	inositol-trisphosphate 3-kinase B	59077	0.12
chr5_131798741_131798941	0.41	ENSG00000202533	.	4998	0.14
chr15_78339587_78339866	0.40	ENSG00000221476	.	8853	0.13
chr21_32561827_32562130	0.40	TIAM1	T-cell lymphoma invasion and metastasis 1	59439	0.15
chr5_75701847_75702137	0.40	IQGAP2	IQ motif containing GTPase activating protein 2	1743	0.49
chr7_105152838_105153078	0.40	PUS7	pseudouridylate synthase 7 homolog (S. cerevisiae)	4376	0.23
chr2_242279172_242279345	0.40	SEPT2	septin 2	2367	0.22
chr13_94050738_94050889	0.40	ENSG00000252365	.	29600	0.26
chr2_42341709_42341982	0.40	EML4	echinoderm microtubule associated protein like 4	54645	0.12
chr7_74595648_74595978	0.39	GTF2IRD2B	GTF2I repeat domain containing 2B	38909	0.17
chr12_74936306_74936457	0.39	RP11-56G10.2		3968	0.28
chr2_60673951_60674102	0.39	AC009970.1		48795	0.14
chr11_121327332_121327753	0.39	RP11-730K11.1		3820	0.28
chr1_154912617_154913094	0.39	PMVK	phosphomevalonate kinase	3388	0.11
chr10_104082217_104082368	0.38	ENSG00000251989	.	61305	0.07
chr10_13386024_13386175	0.38	SEPHS1	selenophosphate synthetase 1	3259	0.24
chr7_12444012_12444163	0.38	VWDE	von Willebrand factor D and EGF domains	556	0.86
chr9_92315939_92316332	0.38	GADD45G	growth arrest and DNA-damage-inducible, gamma	96182	0.09
chr2_175201853_175202044	0.38	AC018470.1	Uncharacterized protein FLJ46347	203	0.92
chr4_4317352_4317503	0.37	ZBTB49	zinc finger and BTB domain containing 49	13073	0.18
chr7_30319289_30319440	0.37	ZNRF2	zinc and ring finger 2	4559	0.23
chr5_157279237_157279388	0.37	CLINT1	clathrin interactor 1	6829	0.23
chr11_14664037_14664267	0.37	PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1	1011	0.43
chr3_141194169_141194577	0.37	RASA2	RAS p21 protein activator 2	11518	0.22
chr2_85895732_85896116	0.37	SFTPB	surfactant protein B	60	0.96
chr9_75567554_75567705	0.37	ALDH1A1	aldehyde dehydrogenase 1 family, member A1	342	0.94
chr18_74212612_74212763	0.37	RP11-17M16.1	uncharacterized protein LOC400658	5210	0.18
chr21_45303314_45303465	0.36	AGPAT3	1-acylglycerol-3-phosphate O-acyltransferase 3	964	0.57
chr10_126228599_126228829	0.36	LHPP	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	78302	0.09
chr2_114321807_114321958	0.36	ENSG00000221055	.	18791	0.16
chr1_17956374_17956572	0.36	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like	11624	0.28
chr12_21831996_21832380	0.36	RP11-59N23.3		16941	0.18
chr12_75851152_75851303	0.35	GLIPR1	GLI pathogenesis-related 1	23233	0.16
chr5_171427537_171427688	0.35	FBXW11	F-box and WD repeat domain containing 11	3621	0.3
chr4_90878223_90878385	0.35	MMRN1	multimerin 1	55170	0.16
chr17_14220339_14220600	0.35	HS3ST3B1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	16069	0.26
chr14_22952984_22953135	0.35	ENSG00000251002	.	1111	0.3
chr7_36325933_36326467	0.35	EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	10553	0.18
chr17_19273582_19274475	0.35	MAPK7	mitogen-activated protein kinase 7	7006	0.11
chr21_36410531_36410893	0.35	RUNX1	runt-related transcription factor 1	10750	0.32
chr12_92478066_92478217	0.35	C12orf79	chromosome 12 open reading frame 79	52656	0.13
chrX_119737541_119737692	0.35	MCTS1	malignant T cell amplified sequence 1	219	0.93
chr10_90747212_90747556	0.34	FAS	Fas cell surface death receptor	3030	0.19
chr22_24830948_24831363	0.34	ADORA2A	adenosine A2a receptor	2347	0.28
chr8_102713284_102713482	0.34	KB-1107E3.1		14608	0.22
chr1_203294006_203294279	0.34	ENSG00000202300	.	5915	0.19
chr7_13133751_13133902	0.34	ENSG00000222974	.	217517	0.02
chr12_32419800_32419951	0.34	BICD1	bicaudal D homolog 1 (Drosophila)	61461	0.13
chr3_4559229_4559481	0.34	ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	1179	0.55
chr2_135031193_135031344	0.33	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	19438	0.24
chr11_113997404_113997555	0.33	ENSG00000221112	.	39828	0.17
chr16_74560683_74560834	0.33	GLG1	golgi glycoprotein 1	36465	0.15
chr7_38714149_38714300	0.33	FAM183B	family with sequence similarity 183, member B	12413	0.24
chr3_47099072_47099238	0.33	ENSG00000251938	.	30943	0.15
chr2_42523506_42523974	0.33	EML4	echinoderm microtubule associated protein like 4	4653	0.29
chr1_181059536_181059906	0.33	IER5	immediate early response 5	2083	0.37
chr13_51185358_51185546	0.33	DLEU7-AS1	DLEU7 antisense RNA 1	196540	0.03
chr12_105478171_105478322	0.32	ALDH1L2	aldehyde dehydrogenase 1 family, member L2	95	0.96
chr7_87943895_87944046	0.32	STEAP4	STEAP family member 4	7764	0.24
chr2_3083933_3084084	0.32	ENSG00000238722	.	4464	0.32
chr10_90686436_90686600	0.32	ACTA2-AS1	ACTA2 antisense RNA 1	5882	0.17
chr21_19186267_19186567	0.32	C21orf91	chromosome 21 open reading frame 91	4919	0.23
chr4_24980289_24980589	0.32	CCDC149	coiled-coil domain containing 149	1331	0.55
chr20_40008439_40008590	0.32	EMILIN3	elastin microfibril interfacer 3	13047	0.2
chr2_158290506_158290794	0.32	CYTIP	cytohesin 1 interacting protein	5276	0.24
chr19_15625593_15626001	0.32	CYP4F22	cytochrome P450, family 4, subfamily F, polypeptide 22	6493	0.15
chr2_120285078_120285229	0.32	SCTR	secretin receptor	3083	0.24
chr18_33199033_33199184	0.32	RP11-712P20.2		23243	0.2
chr7_148519000_148519151	0.32	ENSG00000251712	.	971	0.58
chr6_119674802_119674953	0.32	MAN1A1	mannosidase, alpha, class 1A, member 1	3951	0.3
chr9_36145819_36145970	0.32	GLIPR2	GLI pathogenesis-related 2	9152	0.18
chr2_88210407_88210558	0.31	RGPD2	RANBP2-like and GRIP domain containing 2	74827	0.09
chr12_102276162_102276313	0.31	DRAM1	DNA-damage regulated autophagy modulator 1	4776	0.16
chr9_117126749_117127269	0.31	AKNA	AT-hook transcription factor	12235	0.19
chr4_9428848_9428999	0.31	ENSG00000252307	.	15944	0.11
chr2_68385602_68386003	0.31	PNO1	partner of NOB1 homolog (S. cerevisiae)	826	0.45
chr9_51365_51516	0.31	RP11-143M1.2		21261	0.19
chr11_48065545_48066080	0.31	AC103828.1		28405	0.17
chr9_4325119_4325384	0.31	GLIS3	GLIS family zinc finger 3	25335	0.17
chr2_144235573_144235784	0.31	AC096558.1		2672	0.38
chr10_134403005_134403189	0.31	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	18333	0.23
chr9_79234557_79234812	0.31	PRUNE2	prune homolog 2 (Drosophila)	32781	0.17
chr18_32624943_32625387	0.31	MAPRE2	microtubule-associated protein, RP/EB family, member 2	3551	0.36
chr2_84684670_84684900	0.31	SUCLG1	succinate-CoA ligase, alpha subunit	1819	0.48
chr13_47992322_47992473	0.31	ENSG00000244521	.	40972	0.23
chr2_237886238_237886389	0.31	ENSG00000202341	.	37635	0.18
chr20_37184274_37184425	0.30	ADIG	adipogenin	25489	0.13
chr3_113955237_113955388	0.30	ZNF80	zinc finger protein 80	1113	0.48
chr4_175029310_175029461	0.30	FBXO8	F-box protein 8	175429	0.03
chr9_5846551_5846725	0.30	ERMP1	endoplasmic reticulum metallopeptidase 1	13521	0.19
chr1_55660397_55660593	0.30	USP24	ubiquitin specific peptidase 24	20267	0.21
chr2_7197696_7198047	0.30	AC019048.1		20140	0.23
chr10_65012309_65012460	0.30	JMJD1C	jumonji domain containing 1C	16442	0.26
chr15_63804900_63805051	0.30	USP3	ubiquitin specific peptidase 3	2670	0.32
chr3_3213817_3214181	0.30	CRBN	cereblon	7359	0.19
chr13_74289274_74289507	0.30	KLF12	Kruppel-like factor 12	279796	0.01
chr2_54004004_54004155	0.30	CHAC2	ChaC, cation transport regulator homolog 2 (E. coli)	9150	0.15
chr5_57787468_57787619	0.30	GAPT	GRB2-binding adaptor protein, transmembrane	279	0.92
chr6_111134072_111134223	0.30	CDK19	cyclin-dependent kinase 19	2152	0.3
chr20_30653904_30654055	0.30	HCK	hemopoietic cell kinase	13915	0.12
chr14_75612464_75612670	0.30	NEK9	NIMA-related kinase 9	18520	0.13
chr6_112046537_112046688	0.30	FYN	FYN oncogene related to SRC, FGR, YES	5347	0.28
chr8_126521344_126521495	0.30	ENSG00000266452	.	64612	0.13
chr4_73257014_73257165	0.30	RP11-373J21.1		68344	0.14
chr3_148898157_148898308	0.30	CP	ceruloplasmin (ferroxidase)	824	0.65
chr21_46530039_46530452	0.29	PRED58		4628	0.17
chr11_5818563_5818714	0.29	OR52N1	olfactory receptor, family 52, subfamily N, member 1	8592	0.12
chr7_128720941_128721092	0.29	ENSG00000238733	.	19431	0.15
chr9_4766664_4766815	0.29	AK3	adenylate kinase 3	24696	0.15
chr2_225799627_225799778	0.29	DOCK10	dedicator of cytokinesis 10	12080	0.29
chr15_74224861_74225012	0.29	LOXL1-AS1	LOXL1 antisense RNA 1	4347	0.17
chr9_112920768_112920919	0.29	AKAP2	A kinase (PRKA) anchor protein 2	33062	0.19
chr5_126907475_126907626	0.29	PRRC1	proline-rich coiled-coil 1	54202	0.15
chr16_31469602_31469809	0.29	ARMC5	armadillo repeat containing 5	304	0.75
chr8_145239667_145240434	0.29	MROH1	maestro heat-like repeat family member 1	21377	0.11
chr7_130780107_130780479	0.29	LINC-PINT	long intergenic non-protein coding RNA, p53 induced transcript	7060	0.22
chr9_134146913_134147198	0.29	FAM78A	family with sequence similarity 78, member A	1145	0.48
chr1_23852013_23852546	0.29	E2F2	E2F transcription factor 2	5433	0.19
chr16_31075251_31075402	0.28	ZNF668	zinc finger protein 668	964	0.26
chr13_100635255_100635469	0.28	ZIC2	Zic family member 2	1336	0.43
chr16_12175053_12175238	0.28	RP11-276H1.3		9014	0.17
chr2_114457524_114457975	0.28	ENSG00000202427	.	19061	0.16
chr3_108047727_108047992	0.28	ENSG00000221724	.	8620	0.23
chr8_135033119_135033449	0.28	ENSG00000212273	.	376316	0.01
chr1_19455827_19455978	0.28	UBR4	ubiquitin protein ligase E3 component n-recognin 4	10559	0.2
chr15_53847423_53847574	0.28	ENSG00000252066	.	96676	0.09
chr21_47893746_47893897	0.28	DIP2A-IT1	DIP2A intronic transcript 1 (non-protein coding)	11437	0.16
chr5_157251804_157251955	0.28	ENSG00000206819	.	15773	0.18
chrX_18513070_18513221	0.28	CDKL5	cyclin-dependent kinase-like 5	52837	0.15
chr1_92954823_92954974	0.28	GFI1	growth factor independent 1 transcription repressor	2465	0.38
chr4_153030332_153030483	0.28	ENSG00000266244	.	119213	0.06
chr17_17664043_17664194	0.28	RAI1-AS1	RAI1 antisense RNA 1	10017	0.13
chr6_24962830_24963080	0.28	FAM65B	family with sequence similarity 65, member B	26767	0.19
chr8_9450617_9450846	0.28	TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	18214	0.23
chrX_109351476_109351643	0.27	ENSG00000265584	.	26213	0.2
chr21_36416402_36416644	0.27	RUNX1	runt-related transcription factor 1	4939	0.36
chr5_138720278_138720769	0.27	SLC23A1	solute carrier family 23 (ascorbic acid transporter), member 1	281	0.82
chr18_76930724_76930875	0.27	CTD-2286N8.2		53592	0.15
chr4_48265932_48266083	0.27	TEC	tec protein tyrosine kinase	5874	0.26
chr10_46934055_46934235	0.27	RP11-38L15.3		17327	0.15
chr4_177557559_177557710	0.27	RP11-313E19.2		33138	0.24
chr20_43782810_43782961	0.27	PI3	peptidase inhibitor 3, skin-derived	20632	0.12
chr11_128355434_128355619	0.27	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	19763	0.23
chr3_169498435_169498680	0.27	RP11-362K14.5		435	0.67
chr6_34985267_34985418	0.27	TCP11	t-complex 11, testis-specific	103480	0.06

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF274

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0032025	response to cobalt ion(GO:0032025)
0.1	0.4	GO:1902170	cellular response to nitric oxide(GO:0071732) cellular response to reactive nitrogen species(GO:1902170)
0.1	0.3	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1	0.2	GO:0071436	sodium ion export(GO:0071436)
0.1	0.3	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.3	GO:0042447	hormone catabolic process(GO:0042447)
0.1	0.3	GO:0009109	coenzyme catabolic process(GO:0009109)
0.1	0.2	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.2	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.1	0.2	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.2	GO:0016102	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.4	GO:0006067	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.1	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.1	GO:0032203	telomere formation via telomerase(GO:0032203)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.2	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.2	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.1	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.1	GO:1904358	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.1	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.2	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.1	GO:0030186	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.2	GO:0046033	AMP metabolic process(GO:0046033)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.0	GO:0046532	regulation of photoreceptor cell differentiation(GO:0046532)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.2	GO:0033005	positive regulation of mast cell activation(GO:0033005)
0.0	0.1	GO:0051533	positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0	0.1	GO:0035588	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:2000351	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.2	GO:0031648	protein destabilization(GO:0031648)
0.0	0.1	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0043301	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0	0.1	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0034260	negative regulation of GTPase activity(GO:0034260)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.2	GO:0007128	meiotic prophase I(GO:0007128)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.1	GO:0035609	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.1	GO:0010193	response to ozone(GO:0010193)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.0	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0048488	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.0	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.0	GO:0043116	negative regulation of vascular permeability(GO:0043116)
0.0	0.0	GO:0060462	lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.2	GO:0045576	mast cell activation(GO:0045576)
0.0	0.1	GO:0048679	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.1	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.0	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.0	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.1	GO:0031442	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.0	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.0	0.1	GO:0050775	positive regulation of dendrite morphogenesis(GO:0050775)
0.0	0.2	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.0	GO:0052031	modulation by symbiont of host defense response(GO:0052031) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0033023	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.2	GO:0006825	copper ion transport(GO:0006825)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0046348	amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0	0.1	GO:0002031	G-protein coupled receptor internalization(GO:0002031)
0.0	0.0	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.0	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)
0.0	0.0	GO:0002467	germinal center formation(GO:0002467)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.1	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.1	GO:0016556	mRNA modification(GO:0016556)
0.0	0.0	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.2	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.0	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005787	signal peptidase complex(GO:0005787)
0.1	0.4	GO:0042599	lamellar body(GO:0042599)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.2	GO:0005682	U5 snRNP(GO:0005682)
0.0	0.2	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.3	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.2	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.2	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.2	GO:0032838	cell projection cytoplasm(GO:0032838)
0.0	0.1	GO:0000145	exocyst(GO:0000145)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.5	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.0	GO:0033150	cytoskeletal calyx(GO:0033150)
0.0	0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.1	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.0	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	0.0	GO:0070081	clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0	0.0	GO:0030673	axolemma(GO:0030673)
0.0	0.0	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.1	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.1	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0012510	trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0	0.0	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0016011	dystroglycan complex(GO:0016011)
0.0	0.1	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.1	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.2	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.1	GO:0017119	Golgi transport complex(GO:0017119)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.1	0.3	GO:0031177	phosphopantetheine binding(GO:0031177)
0.1	0.2	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.1	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1	0.2	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1	0.2	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.2	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.2	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.3	GO:0016854	racemase and epimerase activity(GO:0016854)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.3	GO:0030276	clathrin binding(GO:0030276)
0.0	0.4	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.2	GO:0098988	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0	0.1	GO:0010861	thyroid hormone receptor activator activity(GO:0010861)
0.0	0.3	GO:0004303	estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0	0.2	GO:0042171	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.1	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.0	GO:0010521	telomerase inhibitor activity(GO:0010521)
0.0	0.2	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	0.0	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.0	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.0	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.0	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.5	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.0	0.0	GO:0032138	single base insertion or deletion binding(GO:0032138)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.0	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.0	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0	0.0	GO:0004083	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.7	GO:0050660	flavin adenine dinucleotide binding(GO:0050660)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.0	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.2	GO:0043022	ribosome binding(GO:0043022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.3	ST GAQ PATHWAY	G alpha q Pathway
0.4	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.3	PID ARF6 PATHWAY	Arf6 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.3	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.7	REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.2	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.2	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.2	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.1	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.1	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.4	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion