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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for ZNF274

Z-value: 1.31

Motif logo

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Transcription factors associated with ZNF274

Gene Symbol Gene ID Gene Info
ZNF274
ENSG00000171606.13 zinc finger protein 274

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr19_58693943_58694152ZNF2743490.824205-0.561.2e-01Click!
chr19_58694466_58694617ZNF2741450.938271-0.472.1e-01Click!
chr19_58695110_58695333ZNF2743580.817942-0.412.7e-01Click!
chr19_58693650_58693919ZNF2746120.642528-0.333.9e-01Click!
chr19_58695365_58695593ZNF2746160.639644-0.264.9e-01Click!

Activity of the ZNF274 motif across conditions

Conditions sorted by the z-value of the ZNF274 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr16_89365642_89366074 2.42 AC137932.5
1594
 0.28
chr19_58868146_58868568 1.44 CTD-2619J13.9
1008
 0.25
chr16_89366119_89366411 1.03 AC137932.5
2001
 0.23
chr2_242680975_242681169 0.88 D2HGDH
 D-2-hydroxyglutarate dehydrogenase
 776
 0.45
chr7_148767712_148767863 0.78 ZNF786
 zinc finger protein 786
 20010
 0.12
chr20_24962486_24962637 0.66 ENSG00000207355
 .
 7754
 0.18
chr3_15316866_15317185 0.62 SH3BP5
 SH3-domain binding protein 5 (BTK-associated)
 391
 0.81
chr17_27068859_27069066 0.57 AC010761.6
821
 0.26
chr7_81396029_81396416 0.57 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
 3065
 0.4
chr1_6041214_6041365 0.56 KCNAB2
 potassium voltage-gated channel, shaker-related subfamily, beta member 2
 10237
 0.18
chr20_418602_419173 0.56 ENSG00000206797
 .
 12420
 0.15
chr11_48037642_48037830 0.55 AC103828.1
329
 0.9
chr6_6726794_6727009 0.55 LY86-AS1
 LY86 antisense RNA 1
 103897
 0.08
chr7_140058154_140058347 0.55 SLC37A3
 solute carrier family 37, member 3
 6350
 0.15
chr5_169708109_169708260 0.54 LCP2
 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
 13853
 0.22
chr4_88313270_88313528 0.54 HSD17B11
 hydroxysteroid (17-beta) dehydrogenase 11
 861
 0.54
chr15_90480001_90480190 0.54 C15orf38
 chromosome 15 open reading frame 38
 23907
 0.1
chr11_122939463_122939751 0.53 HSPA8
 heat shock 70kDa protein 8
 5669
 0.16
chr20_25655869_25656020 0.53 ZNF337
 zinc finger protein 337
 11402
 0.16
chr1_10461491_10461642 0.53 PGD
 phosphogluconate dehydrogenase
 1877
 0.22
chr3_13050536_13050725 0.52 IQSEC1
 IQ motif and Sec7 domain 1
 22094
 0.24
chr14_35400530_35400841 0.51 ENSG00000199980
 .
 2064
 0.3
chr13_24852090_24852325 0.51 SPATA13
 spermatogenesis associated 13
 5380
 0.18
chrX_153214056_153214561 0.50 RENBP
 renin binding protein
 4076
 0.1
chr11_10765370_10765523 0.49 CTR9
 CTR9, Paf1/RNA polymerase II complex component
 7088
 0.15
chr13_29156493_29156762 0.49 POMP
 proteasome maturation protein
 76614
 0.1
chr16_1538550_1538777 0.48 PTX4
 pentraxin 4, long
 195
 0.86
chr14_91874860_91875123 0.48 CCDC88C
 coiled-coil domain containing 88C
 8699
 0.24
chr9_92316642_92316885 0.47 GADD45G
 growth arrest and DNA-damage-inducible, gamma
 96810
 0.09
chr10_104197193_104197463 0.47 ENSG00000202569
 .
 1059
 0.32
chr14_91817459_91817741 0.46 ENSG00000265856
 .
 17543
 0.21
chr5_58568933_58569140 0.46 PDE4D
 phosphodiesterase 4D, cAMP-specific
 2909
 0.42
chr19_51919928_51920449 0.45 SIGLEC10
 sialic acid binding Ig-like lectin 10
 647
 0.4
chr13_25200724_25201013 0.45 ENSG00000211508
 .
 17651
 0.18
chr16_87076415_87076642 0.45 RP11-899L11.3
172993
 0.03
chr21_36384069_36384311 0.45 RUNX1
 runt-related transcription factor 1
 37272
 0.23
chr3_176784016_176784245 0.45 TBL1XR1-AS1
 TBL1XR1 antisense RNA 1
 21481
 0.22
chr1_25782884_25783035 0.45 TMEM57
 transmembrane protein 57
 25548
 0.14
chr13_98396488_98396639 0.44 ENSG00000238407
 .
 141500
 0.05
chr12_117033216_117033367 0.44 MAP1LC3B2
 microtubule-associated protein 1 light chain 3 beta 2
 19635
 0.25
chr4_185772755_185773053 0.44 ENSG00000266698
 .
 640
 0.72
chr4_26385783_26386117 0.44 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 21798
 0.26
chrX_37684198_37684679 0.44 DYNLT3
 dynein, light chain, Tctex-type 3
 22223
 0.19
chr13_111173056_111173211 0.44 COL4A2-AS1
 COL4A2 antisense RNA 1
 12607
 0.2
chr18_55334626_55334855 0.43 ATP8B1
 ATPase, aminophospholipid transporter, class I, type 8B, member 1
 21160
 0.15
chr3_71760476_71760839 0.43 EIF4E3
 eukaryotic translation initiation factor 4E family member 3
 13869
 0.22
chrX_1590509_1590809 0.43 ASMTL
 acetylserotonin O-methyltransferase-like
 18004
 0.18
chrY_1540506_1540807 0.42 NA
 NA
 > 106
 NA
chr4_124399364_124399515 0.42 SPRY1
 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
 78316
 0.12
chr1_65472844_65472995 0.42 ENSG00000212257
 .
 15838
 0.19
chr12_11963905_11964056 0.42 ETV6
 ets variant 6
 58545
 0.15
chr11_67179086_67179395 0.42 CARNS1
 carnosine synthase 1
 3909
 0.08
chr2_223485669_223485820 0.42 FARSB
 phenylalanyl-tRNA synthetase, beta subunit
 35026
 0.15
chr9_140171055_140171601 0.42 TOR4A
 torsin family 4, member A
 873
 0.34
chr5_64318013_64318164 0.41 ENSG00000207439
 .
 101108
 0.08
chr1_226985906_226986297 0.41 ITPKB
 inositol-trisphosphate 3-kinase B
 59077
 0.12
chr5_131798741_131798941 0.41 ENSG00000202533
 .
 4998
 0.14
chr15_78339587_78339866 0.40 ENSG00000221476
 .
 8853
 0.13
chr21_32561827_32562130 0.40 TIAM1
 T-cell lymphoma invasion and metastasis 1
 59439
 0.15
chr5_75701847_75702137 0.40 IQGAP2
 IQ motif containing GTPase activating protein 2
 1743
 0.49
chr7_105152838_105153078 0.40 PUS7
 pseudouridylate synthase 7 homolog (S. cerevisiae)
 4376
 0.23
chr2_242279172_242279345 0.40 SEPT2
 septin 2
 2367
 0.22
chr13_94050738_94050889 0.40 ENSG00000252365
 .
 29600
 0.26
chr2_42341709_42341982 0.40 EML4
 echinoderm microtubule associated protein like 4
 54645
 0.12
chr7_74595648_74595978 0.39 GTF2IRD2B
 GTF2I repeat domain containing 2B
 38909
 0.17
chr12_74936306_74936457 0.39 RP11-56G10.2
3968
 0.28
chr2_60673951_60674102 0.39 AC009970.1
48795
 0.14
chr11_121327332_121327753 0.39 RP11-730K11.1
3820
 0.28
chr1_154912617_154913094 0.39 PMVK
 phosphomevalonate kinase
 3388
 0.11
chr10_104082217_104082368 0.38 ENSG00000251989
 .
 61305
 0.07
chr10_13386024_13386175 0.38 SEPHS1
 selenophosphate synthetase 1
 3259
 0.24
chr7_12444012_12444163 0.38 VWDE
 von Willebrand factor D and EGF domains
 556
 0.86
chr9_92315939_92316332 0.38 GADD45G
 growth arrest and DNA-damage-inducible, gamma
 96182
 0.09
chr2_175201853_175202044 0.38 AC018470.1
 Uncharacterized protein FLJ46347
 203
 0.92
chr4_4317352_4317503 0.37 ZBTB49
 zinc finger and BTB domain containing 49
 13073
 0.18
chr7_30319289_30319440 0.37 ZNRF2
 zinc and ring finger 2
 4559
 0.23
chr5_157279237_157279388 0.37 CLINT1
 clathrin interactor 1
 6829
 0.23
chr11_14664037_14664267 0.37 PSMA1
 proteasome (prosome, macropain) subunit, alpha type, 1
 1011
 0.43
chr3_141194169_141194577 0.37 RASA2
 RAS p21 protein activator 2
 11518
 0.22
chr2_85895732_85896116 0.37 SFTPB
 surfactant protein B
 60
 0.96
chr9_75567554_75567705 0.37 ALDH1A1
 aldehyde dehydrogenase 1 family, member A1
 342
 0.94
chr18_74212612_74212763 0.37 RP11-17M16.1
 uncharacterized protein LOC400658
 5210
 0.18
chr21_45303314_45303465 0.36 AGPAT3
 1-acylglycerol-3-phosphate O-acyltransferase 3
 964
 0.57
chr10_126228599_126228829 0.36 LHPP
 phospholysine phosphohistidine inorganic pyrophosphate phosphatase
 78302
 0.09
chr2_114321807_114321958 0.36 ENSG00000221055
 .
 18791
 0.16
chr1_17956374_17956572 0.36 ARHGEF10L
 Rho guanine nucleotide exchange factor (GEF) 10-like
 11624
 0.28
chr12_21831996_21832380 0.36 RP11-59N23.3
16941
 0.18
chr12_75851152_75851303 0.35 GLIPR1
 GLI pathogenesis-related 1
 23233
 0.16
chr5_171427537_171427688 0.35 FBXW11
 F-box and WD repeat domain containing 11
 3621
 0.3
chr4_90878223_90878385 0.35 MMRN1
 multimerin 1
 55170
 0.16
chr17_14220339_14220600 0.35 HS3ST3B1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
 16069
 0.26
chr14_22952984_22953135 0.35 ENSG00000251002
 .
 1111
 0.3
chr7_36325933_36326467 0.35 EEPD1
 endonuclease/exonuclease/phosphatase family domain containing 1
 10553
 0.18
chr17_19273582_19274475 0.35 MAPK7
 mitogen-activated protein kinase 7
 7006
 0.11
chr21_36410531_36410893 0.35 RUNX1
 runt-related transcription factor 1
 10750
 0.32
chr12_92478066_92478217 0.35 C12orf79
 chromosome 12 open reading frame 79
 52656
 0.13
chrX_119737541_119737692 0.35 MCTS1
 malignant T cell amplified sequence 1
 219
 0.93
chr10_90747212_90747556 0.34 FAS
 Fas cell surface death receptor
 3030
 0.19
chr22_24830948_24831363 0.34 ADORA2A
 adenosine A2a receptor
 2347
 0.28
chr8_102713284_102713482 0.34 KB-1107E3.1
14608
 0.22
chr1_203294006_203294279 0.34 ENSG00000202300
 .
 5915
 0.19
chr7_13133751_13133902 0.34 ENSG00000222974
 .
 217517
 0.02
chr12_32419800_32419951 0.34 BICD1
 bicaudal D homolog 1 (Drosophila)
 61461
 0.13
chr3_4559229_4559481 0.34 ITPR1
 inositol 1,4,5-trisphosphate receptor, type 1
 1179
 0.55
chr2_135031193_135031344 0.33 MGAT5
 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
 19438
 0.24
chr11_113997404_113997555 0.33 ENSG00000221112
 .
 39828
 0.17
chr16_74560683_74560834 0.33 GLG1
 golgi glycoprotein 1
 36465
 0.15
chr7_38714149_38714300 0.33 FAM183B
 family with sequence similarity 183, member B
 12413
 0.24
chr3_47099072_47099238 0.33 ENSG00000251938
 .
 30943
 0.15
chr2_42523506_42523974 0.33 EML4
 echinoderm microtubule associated protein like 4
 4653
 0.29
chr1_181059536_181059906 0.33 IER5
 immediate early response 5
 2083
 0.37
chr13_51185358_51185546 0.33 DLEU7-AS1
 DLEU7 antisense RNA 1
 196540
 0.03
chr12_105478171_105478322 0.32 ALDH1L2
 aldehyde dehydrogenase 1 family, member L2
 95
 0.96
chr7_87943895_87944046 0.32 STEAP4
 STEAP family member 4
 7764
 0.24
chr2_3083933_3084084 0.32 ENSG00000238722
 .
 4464
 0.32
chr10_90686436_90686600 0.32 ACTA2-AS1
 ACTA2 antisense RNA 1
 5882
 0.17
chr21_19186267_19186567 0.32 C21orf91
 chromosome 21 open reading frame 91
 4919
 0.23
chr4_24980289_24980589 0.32 CCDC149
 coiled-coil domain containing 149
 1331
 0.55
chr20_40008439_40008590 0.32 EMILIN3
 elastin microfibril interfacer 3
 13047
 0.2
chr2_158290506_158290794 0.32 CYTIP
 cytohesin 1 interacting protein
 5276
 0.24
chr19_15625593_15626001 0.32 CYP4F22
 cytochrome P450, family 4, subfamily F, polypeptide 22
 6493
 0.15
chr2_120285078_120285229 0.32 SCTR
 secretin receptor
 3083
 0.24
chr18_33199033_33199184 0.32 RP11-712P20.2
23243
 0.2
chr7_148519000_148519151 0.32 ENSG00000251712
 .
 971
 0.58
chr6_119674802_119674953 0.32 MAN1A1
 mannosidase, alpha, class 1A, member 1
 3951
 0.3
chr9_36145819_36145970 0.32 GLIPR2
 GLI pathogenesis-related 2
 9152
 0.18
chr2_88210407_88210558 0.31 RGPD2
 RANBP2-like and GRIP domain containing 2
 74827
 0.09
chr12_102276162_102276313 0.31 DRAM1
 DNA-damage regulated autophagy modulator 1
 4776
 0.16
chr9_117126749_117127269 0.31 AKNA
 AT-hook transcription factor
 12235
 0.19
chr4_9428848_9428999 0.31 ENSG00000252307
 .
 15944
 0.11
chr2_68385602_68386003 0.31 PNO1
 partner of NOB1 homolog (S. cerevisiae)
 826
 0.45
chr9_51365_51516 0.31 RP11-143M1.2
21261
 0.19
chr11_48065545_48066080 0.31 AC103828.1
28405
 0.17
chr9_4325119_4325384 0.31 GLIS3
 GLIS family zinc finger 3
 25335
 0.17
chr2_144235573_144235784 0.31 AC096558.1
2672
 0.38
chr10_134403005_134403189 0.31 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 18333
 0.23
chr9_79234557_79234812 0.31 PRUNE2
 prune homolog 2 (Drosophila)
 32781
 0.17
chr18_32624943_32625387 0.31 MAPRE2
 microtubule-associated protein, RP/EB family, member 2
 3551
 0.36
chr2_84684670_84684900 0.31 SUCLG1
 succinate-CoA ligase, alpha subunit
 1819
 0.48
chr13_47992322_47992473 0.31 ENSG00000244521
 .
 40972
 0.23
chr2_237886238_237886389 0.31 ENSG00000202341
 .
 37635
 0.18
chr20_37184274_37184425 0.30 ADIG
 adipogenin
 25489
 0.13
chr3_113955237_113955388 0.30 ZNF80
 zinc finger protein 80
 1113
 0.48
chr4_175029310_175029461 0.30 FBXO8
 F-box protein 8
 175429
 0.03
chr9_5846551_5846725 0.30 ERMP1
 endoplasmic reticulum metallopeptidase 1
 13521
 0.19
chr1_55660397_55660593 0.30 USP24
 ubiquitin specific peptidase 24
 20267
 0.21
chr2_7197696_7198047 0.30 AC019048.1
20140
 0.23
chr10_65012309_65012460 0.30 JMJD1C
 jumonji domain containing 1C
 16442
 0.26
chr15_63804900_63805051 0.30 USP3
 ubiquitin specific peptidase 3
 2670
 0.32
chr3_3213817_3214181 0.30 CRBN
 cereblon
 7359
 0.19
chr13_74289274_74289507 0.30 KLF12
 Kruppel-like factor 12
 279796
 0.01
chr2_54004004_54004155 0.30 CHAC2
 ChaC, cation transport regulator homolog 2 (E. coli)
 9150
 0.15
chr5_57787468_57787619 0.30 GAPT
 GRB2-binding adaptor protein, transmembrane
 279
 0.92
chr6_111134072_111134223 0.30 CDK19
 cyclin-dependent kinase 19
 2152
 0.3
chr20_30653904_30654055 0.30 HCK
 hemopoietic cell kinase
 13915
 0.12
chr14_75612464_75612670 0.30 NEK9
 NIMA-related kinase 9
 18520
 0.13
chr6_112046537_112046688 0.30 FYN
 FYN oncogene related to SRC, FGR, YES
 5347
 0.28
chr8_126521344_126521495 0.30 ENSG00000266452
 .
 64612
 0.13
chr4_73257014_73257165 0.30 RP11-373J21.1
68344
 0.14
chr3_148898157_148898308 0.30 CP
 ceruloplasmin (ferroxidase)
 824
 0.65
chr21_46530039_46530452 0.29 PRED58
4628
 0.17
chr11_5818563_5818714 0.29 OR52N1
 olfactory receptor, family 52, subfamily N, member 1
 8592
 0.12
chr7_128720941_128721092 0.29 ENSG00000238733
 .
 19431
 0.15
chr9_4766664_4766815 0.29 AK3
 adenylate kinase 3
 24696
 0.15
chr2_225799627_225799778 0.29 DOCK10
 dedicator of cytokinesis 10
 12080
 0.29
chr15_74224861_74225012 0.29 LOXL1-AS1
 LOXL1 antisense RNA 1
 4347
 0.17
chr9_112920768_112920919 0.29 AKAP2
 A kinase (PRKA) anchor protein 2
 33062
 0.19
chr5_126907475_126907626 0.29 PRRC1
 proline-rich coiled-coil 1
 54202
 0.15
chr16_31469602_31469809 0.29 ARMC5
 armadillo repeat containing 5
 304
 0.75
chr8_145239667_145240434 0.29 MROH1
 maestro heat-like repeat family member 1
 21377
 0.11
chr7_130780107_130780479 0.29 LINC-PINT
 long intergenic non-protein coding RNA, p53 induced transcript
 7060
 0.22
chr9_134146913_134147198 0.29 FAM78A
 family with sequence similarity 78, member A
 1145
 0.48
chr1_23852013_23852546 0.29 E2F2
 E2F transcription factor 2
 5433
 0.19
chr16_31075251_31075402 0.28 ZNF668
 zinc finger protein 668
 964
 0.26
chr13_100635255_100635469 0.28 ZIC2
 Zic family member 2
 1336
 0.43
chr16_12175053_12175238 0.28 RP11-276H1.3
9014
 0.17
chr2_114457524_114457975 0.28 ENSG00000202427
 .
 19061
 0.16
chr3_108047727_108047992 0.28 ENSG00000221724
 .
 8620
 0.23
chr8_135033119_135033449 0.28 ENSG00000212273
 .
 376316
 0.01
chr1_19455827_19455978 0.28 UBR4
 ubiquitin protein ligase E3 component n-recognin 4
 10559
 0.2
chr15_53847423_53847574 0.28 ENSG00000252066
 .
 96676
 0.09
chr21_47893746_47893897 0.28 DIP2A-IT1
 DIP2A intronic transcript 1 (non-protein coding)
 11437
 0.16
chr5_157251804_157251955 0.28 ENSG00000206819
 .
 15773
 0.18
chrX_18513070_18513221 0.28 CDKL5
 cyclin-dependent kinase-like 5
 52837
 0.15
chr1_92954823_92954974 0.28 GFI1
 growth factor independent 1 transcription repressor
 2465
 0.38
chr4_153030332_153030483 0.28 ENSG00000266244
 .
 119213
 0.06
chr17_17664043_17664194 0.28 RAI1-AS1
 RAI1 antisense RNA 1
 10017
 0.13
chr6_24962830_24963080 0.28 FAM65B
 family with sequence similarity 65, member B
 26767
 0.19
chr8_9450617_9450846 0.28 TNKS
 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
 18214
 0.23
chrX_109351476_109351643 0.27 ENSG00000265584
 .
 26213
 0.2
chr21_36416402_36416644 0.27 RUNX1
 runt-related transcription factor 1
 4939
 0.36
chr5_138720278_138720769 0.27 SLC23A1
 solute carrier family 23 (ascorbic acid transporter), member 1
 281
 0.82
chr18_76930724_76930875 0.27 CTD-2286N8.2
53592
 0.15
chr4_48265932_48266083 0.27 TEC
 tec protein tyrosine kinase
 5874
 0.26
chr10_46934055_46934235 0.27 RP11-38L15.3
17327
 0.15
chr4_177557559_177557710 0.27 RP11-313E19.2
33138
 0.24
chr20_43782810_43782961 0.27 PI3
 peptidase inhibitor 3, skin-derived
 20632
 0.12
chr11_128355434_128355619 0.27 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 19763
 0.23
chr3_169498435_169498680 0.27 RP11-362K14.5
435
 0.67
chr6_34985267_34985418 0.27 TCP11
 t-complex 11, testis-specific
 103480
 0.06

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF274

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0032025 response to cobalt ion(GO:0032025)
0.1 0.4 GO:1902170 cellular response to nitric oxide(GO:0071732) cellular response to reactive nitrogen species(GO:1902170)
0.1 0.3 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.2 GO:0071436 sodium ion export(GO:0071436)
0.1 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.3 GO:0042447 hormone catabolic process(GO:0042447)
0.1 0.3 GO:0009109 coenzyme catabolic process(GO:0009109)
0.1 0.2 GO:0010957 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1 0.2 GO:0031558 obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.1 0.2 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.2 GO:0016102 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0 0.4 GO:0006067 ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0 0.1 GO:0030210 heparin biosynthetic process(GO:0030210)
0.0 0.1 GO:0032203 telomere formation via telomerase(GO:0032203)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0 0.1 GO:1904358 positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0 0.1 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.2 GO:0046033 AMP metabolic process(GO:0046033)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.0 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.0 0.1 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.2 GO:0033005 positive regulation of mast cell activation(GO:0033005)
0.0 0.1 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.1 GO:0035588 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.1 GO:2000351 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0 0.2 GO:0031648 protein destabilization(GO:0031648)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.1 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0043301 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0 0.1 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.0 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.1 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.1 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.2 GO:0007128 meiotic prophase I(GO:0007128)
0.0 0.1 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.1 GO:0035609 C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0 0.1 GO:0010193 response to ozone(GO:0010193)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.0 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.0 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0048488 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.0 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.0 GO:0036336 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0 0.0 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 0.0 GO:0060462 lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.0 0.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.2 GO:0045576 mast cell activation(GO:0045576)
0.0 0.1 GO:0048679 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.1 GO:0034616 response to laminar fluid shear stress(GO:0034616)
0.0 0.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.0 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.0 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.0 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.0 0.1 GO:0031442 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.0 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.1 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.0 0.2 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.0 GO:0052031 modulation by symbiont of host defense response(GO:0052031) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553)
0.0 0.0 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.0 GO:0033023 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0 0.2 GO:0006825 copper ion transport(GO:0006825)
0.0 0.0 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.0 GO:1901797 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.1 GO:0046348 amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0 0.1 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.0 0.0 GO:0006681 galactosylceramide metabolic process(GO:0006681)
0.0 0.0 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.0 GO:0051451 myoblast migration(GO:0051451)
0.0 0.0 GO:0002467 germinal center formation(GO:0002467)
0.0 0.0 GO:0046877 regulation of saliva secretion(GO:0046877)
0.0 0.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.1 GO:0001866 NK T cell proliferation(GO:0001866)
0.0 0.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.0 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.1 GO:0016556 mRNA modification(GO:0016556)
0.0 0.0 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.2 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.0 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.4 GO:0042599 lamellar body(GO:0042599)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.2 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.2 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.2 GO:0032279 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.2 GO:0032838 cell projection cytoplasm(GO:0032838)
0.0 0.1 GO:0000145 exocyst(GO:0000145)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.5 GO:0005626 obsolete insoluble fraction(GO:0005626)
0.0 0.0 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.0 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.0 GO:0030673 axolemma(GO:0030673)
0.0 0.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 0.1 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.0 GO:0030904 retromer complex(GO:0030904)
0.0 0.1 GO:0016011 dystroglycan complex(GO:0016011)
0.0 0.1 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 0.3 GO:0031177 phosphopantetheine binding(GO:0031177)
0.1 0.2 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.1 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.2 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.2 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.3 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.3 GO:0030276 clathrin binding(GO:0030276)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0098988 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.1 GO:0010861 thyroid hormone receptor activator activity(GO:0010861)
0.0 0.3 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.2 GO:0042171 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.1 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0052659 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.0 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.0 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.0 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.1 GO:0034190 apolipoprotein receptor binding(GO:0034190)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.1 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.0 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.0 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.0 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.0 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.0 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.0 GO:0004083 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.7 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.0 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.2 GO:0043022 ribosome binding(GO:0043022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.0 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 0.0 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.1 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 0.1 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 ST GAQ PATHWAY G alpha q Pathway
0.0 0.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.0 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 0.3 PID ARF6 PATHWAY Arf6 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.3 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.7 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 0.0 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.0 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.1 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.1 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.2 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.0 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.4 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 0.0 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion