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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZNF282

Z-value: 1.24

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Transcription factors associated with ZNF282

Gene Symbol	Gene ID	Gene Info
ZNF282 Ensembl NCBI GeneCards UniProt	ENSG00000170265.7	ZNF282

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZNF282	chr7_148893289_148893440	722	0.627642	0.90	9.7e-04	Click!
ZNF282	chr7_148893510_148893675	950	0.516032	0.87	2.5e-03	Click!
ZNF282	chr7_148878722_148878873	13780	0.144296	-0.74	2.1e-02	Click!
ZNF282	chr7_148888859_148889047	3624	0.195190	0.69	3.9e-02	Click!
ZNF282	chr7_148877933_148878084	14569	0.142631	-0.67	4.9e-02	Click!

Activity of the ZNF282 motif across conditions

Conditions sorted by the z-value of the ZNF282 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_46572017_46572193	0.70	SLC38A1	solute carrier family 38, member 1	89379	0.1
chr2_96830073_96830240	0.65	DUSP2	dual specificity phosphatase 2	18977	0.13
chr7_142502062_142502213	0.55	PRSS3P2	protease, serine, 3 pseudogene 2	21006	0.16
chr10_82288993_82289258	0.48	RP11-137H2.4		6573	0.22
chr1_109188369_109188646	0.47	HENMT1	HEN1 methyltransferase homolog 1 (Arabidopsis)	15170	0.19
chr12_6573393_6573619	0.47	VAMP1	vesicle-associated membrane protein 1 (synaptobrevin 1)	6305	0.09
chr20_13619077_13619233	0.46	TASP1	taspase, threonine aspartase, 1	395	0.92
chr6_36067796_36067952	0.45	MAPK13	mitogen-activated protein kinase 13	30224	0.14
chr7_3020531_3020974	0.44	ENSG00000201794	.	17976	0.2
chr2_55757616_55757885	0.42	CCDC104	coiled-coil domain containing 104	10883	0.15
chr11_14292192_14292493	0.42	RP11-21L19.1		2895	0.33
chr2_234308315_234308480	0.41	DGKD	diacylglycerol kinase, delta 130kDa	11597	0.17
chr14_91302849_91303150	0.41	TTC7B	tetratricopeptide repeat domain 7B	20176	0.25
chr13_30944650_30944977	0.41	KATNAL1	katanin p60 subunit A-like 1	63192	0.13
chr2_7018212_7018651	0.40	RSAD2	radical S-adenosyl methionine domain containing 2	494	0.78
chr8_82044607_82044805	0.40	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	20403	0.26
chr15_91143512_91143728	0.40	CTD-3065B20.2		3941	0.18
chr10_7237970_7238148	0.40	SFMBT2	Scm-like with four mbt domains 2	212648	0.02
chr1_117310626_117310883	0.39	CD2	CD2 molecule	13665	0.21
chrX_9286819_9287136	0.39	TBL1X	transducin (beta)-like 1X-linked	144358	0.05
chr18_60880123_60880495	0.39	ENSG00000238988	.	18411	0.21
chr19_47948776_47948927	0.39	MEIS3	Meis homeobox 3	26071	0.11
chr14_89817017_89817302	0.38	RP11-356K23.1		513	0.77
chr1_111433483_111434153	0.37	CD53	CD53 molecule	18042	0.16
chrX_103367091_103367582	0.37	ZCCHC18	zinc finger, CCHC domain containing 18	10134	0.18
chr20_50097371_50097649	0.37	ENSG00000266761	.	27996	0.21
chr7_150200817_150201275	0.37	GIMAP7	GTPase, IMAP family member 7	10872	0.18
chr17_37252182_37252943	0.37	PLXDC1	plexin domain containing 1	11178	0.15
chr7_142378873_142379024	0.37	MTRNR2L6	MT-RNR2-like 6	4844	0.28
chr8_129672236_129672673	0.37	ENSG00000221351	.	159586	0.04
chr1_101745654_101745926	0.37	RP4-575N6.5		37076	0.14
chr1_117903396_117903547	0.37	MAN1A2	mannosidase, alpha, class 1A, member 2	6600	0.31
chr9_20373431_20373643	0.36	MLLT3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	8930	0.21
chr16_84119947_84120139	0.36	MBTPS1	membrane-bound transcription factor peptidase, site 1	30357	0.1
chr12_65672789_65672940	0.36	MSRB3	methionine sulfoxide reductase B3	97	0.97
chr3_50611684_50611927	0.36	HEMK1	HemK methyltransferase family member 1	2750	0.2
chr17_37911699_37911850	0.36	GRB7	growth factor receptor-bound protein 7	13269	0.11
chr4_2787896_2788215	0.35	SH3BP2	SH3-domain binding protein 2	6695	0.21
chr18_2636269_2636739	0.35	ENSG00000200875	.	13362	0.14
chr3_32411752_32412018	0.35	CMTM7	CKLF-like MARVEL transmembrane domain containing 7	21278	0.22
chr5_156630874_156631025	0.35	CTB-4E7.1		20441	0.11
chr4_108984413_108984564	0.35	HADH	hydroxyacyl-CoA dehydrogenase	58697	0.12
chr6_37141344_37141568	0.35	PIM1	pim-1 oncogene	3477	0.23
chrX_135839770_135839921	0.34	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	9657	0.18
chr5_158239944_158240095	0.34	CTD-2363C16.1		169995	0.04
chr15_38982599_38982925	0.34	C15orf53	chromosome 15 open reading frame 53	6037	0.31
chr17_17660810_17661016	0.34	RAI1-AS1	RAI1 antisense RNA 1	13222	0.13
chr6_36005080_36005248	0.34	MAPK14	mitogen-activated protein kinase 14	8298	0.19
chr18_29606522_29606811	0.34	RNF125	ring finger protein 125, E3 ubiquitin protein ligase	8331	0.16
chr5_67577719_67577949	0.34	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	1699	0.51
chr9_116288167_116288318	0.33	RGS3	regulator of G-protein signaling 3	8692	0.23
chr1_245020022_245020173	0.33	HNRNPU-AS1	HNRNPU antisense RNA 1	1298	0.41
chr3_13462874_13463150	0.33	NUP210	nucleoporin 210kDa	1203	0.55
chr3_4334985_4335136	0.33	SETMAR	SET domain and mariner transposase fusion gene	9928	0.31
chr14_103368353_103368504	0.33	AMN	amnion associated transmembrane protein	20565	0.12
chr3_13048597_13048870	0.33	IQSEC1	IQ motif and Sec7 domain 1	20197	0.25
chr3_38005322_38005473	0.32	CTDSPL	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like	673	0.64
chr16_80598344_80598524	0.32	RP11-525K10.3		1402	0.4
chr1_235291589_235291740	0.32	ENSG00000207181	.	412	0.58
chr1_54946775_54946928	0.32	ENSG00000265404	.	23490	0.17
chr12_123592299_123592450	0.32	PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2	2601	0.28
chr5_14794238_14794389	0.32	ENSG00000264792	.	31808	0.19
chr15_52046369_52046544	0.32	CTD-2308G16.1		1774	0.24
chr3_15308861_15309012	0.32	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	8480	0.14
chrY_2874457_2874608	0.32	ZFY-AS1	ZFY antisense RNA 1	3865	0.34
chr5_169704104_169704255	0.32	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	9848	0.22
chr3_186678062_186678218	0.32	ST6GAL1	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	14605	0.21
chr1_27944687_27944855	0.32	FGR	feline Gardner-Rasheed sarcoma viral oncogene homolog	5802	0.15
chr22_22603206_22603357	0.31	VPREB1	pre-B lymphocyte 1	4089	0.1
chr5_14701641_14701810	0.31	FAM105B	family with sequence similarity 105, member B	20066	0.2
chr2_95688672_95688933	0.31	MAL	mal, T-cell differentiation protein	2627	0.21
chr17_35447597_35447771	0.31	ACACA	acetyl-CoA carboxylase alpha	1766	0.34
chr14_105532821_105533069	0.31	GPR132	G protein-coupled receptor 132	1163	0.49
chr11_124813257_124813486	0.31	HEPACAM	hepatic and glial cell adhesion molecule	7063	0.13
chr5_39175704_39176163	0.31	FYB	FYN binding protein	27196	0.22
chr17_14221651_14221911	0.31	HS3ST3B1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	17381	0.25
chr11_118182213_118182479	0.31	CD3E	CD3e molecule, epsilon (CD3-TCR complex)	6732	0.13
chr13_42070374_42070546	0.31	RGCC	regulator of cell cycle	38765	0.13
chr3_43343792_43343998	0.31	ENSG00000241939	.	12548	0.17
chr18_13465523_13465878	0.31	LDLRAD4	low density lipoprotein receptor class A domain containing 4	686	0.52
chr21_36409118_36409316	0.31	RUNX1	runt-related transcription factor 1	12245	0.31
chr19_6775713_6775940	0.30	VAV1	vav 1 guanine nucleotide exchange factor	2857	0.17
chr2_169290019_169290449	0.30	ENSG00000239230	.	7481	0.21
chr13_22032610_22032761	0.30	ZDHHC20	zinc finger, DHHC-type containing 20	729	0.72
chr12_11697430_11697755	0.30	ENSG00000251747	.	1821	0.33
chr10_98516773_98516924	0.30	ENSG00000207287	.	13924	0.19
chr7_105525970_105526305	0.30	ATXN7L1	ataxin 7-like 1	9087	0.29
chr8_21772448_21772871	0.30	DOK2	docking protein 2, 56kDa	1288	0.44
chr21_43658442_43658806	0.30	ENSG00000223262	.	17341	0.16
chr3_18412272_18412602	0.30	RP11-158G18.1		38690	0.18
chr4_40230061_40230375	0.30	RHOH	ras homolog family member H	28254	0.18
chr2_241342781_241342932	0.30	GPC1	glypican 1	32232	0.15
chr15_64128117_64128268	0.30	HERC1	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	2051	0.37
chr2_8596031_8596222	0.30	AC011747.7		219770	0.02
chr1_12405618_12405821	0.30	VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)	64205	0.11
chr19_55764964_55765151	0.30	PPP6R1	protein phosphatase 6, regulatory subunit 1	2080	0.15
chr1_121347938_121348091	0.30	FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)	412077	0.01
chr20_25676704_25676934	0.29	ZNF337	zinc finger protein 337	658	0.71
chr2_198075189_198075340	0.29	ANKRD44	ankyrin repeat domain 44	12502	0.2
chr7_138728882_138729132	0.29	ZC3HAV1L	zinc finger CCCH-type, antiviral 1-like	8232	0.21
chr12_104912220_104912483	0.29	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	61572	0.13
chr6_41976653_41976895	0.29	ENSG00000206875	.	9478	0.16
chr19_19051022_19051173	0.29	HOMER3	homer homolog 3 (Drosophila)	16	0.5
chr5_130852523_130852701	0.29	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	8762	0.3
chr18_21059346_21059497	0.29	RIOK3	RIO kinase 3	2269	0.26
chr11_121416006_121416228	0.29	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	21317	0.27
chr10_11364003_11364154	0.29	CELF2-AS1	CELF2 antisense RNA 1	2231	0.44
chr9_134145646_134145833	0.29	FAM78A	family with sequence similarity 78, member A	141	0.96
chr9_37075041_37075192	0.29	RP11-220I1.2		40371	0.13
chr10_112603695_112603846	0.29	PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	27795	0.13
chr6_37469689_37469840	0.28	CCDC167	coiled-coil domain containing 167	2066	0.34
chr2_143975242_143975418	0.28	RP11-190J23.1		45589	0.18
chr17_78721062_78721213	0.28	RP11-28G8.1		58295	0.13
chr13_52394867_52395060	0.28	RP11-327P2.5		16530	0.18
chr8_91640248_91640450	0.28	TMEM64	transmembrane protein 64	17391	0.21
chr12_54675160_54675465	0.28	HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	342	0.7
chr2_225895814_225896091	0.28	DOCK10	dedicator of cytokinesis 10	11207	0.25
chr2_106380015_106380293	0.28	NCK2	NCK adaptor protein 2	17966	0.27
chr18_46586685_46586836	0.28	ENSG00000263849	.	10622	0.19
chr5_54398513_54398753	0.28	GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	157	0.94
chr4_84028872_84029038	0.28	PLAC8	placenta-specific 8	2041	0.38
chr1_208004097_208004248	0.28	ENSG00000203709	.	28304	0.2
chr12_7344185_7344336	0.28	PEX5	peroxisomal biogenesis factor 5	852	0.49
chr8_61812488_61812744	0.28	RP11-33I11.2		90451	0.09
chr20_31000245_31000406	0.28	ASXL1	additional sex combs like 1 (Drosophila)	18340	0.18
chr9_77767149_77767402	0.28	ENSG00000200041	.	29262	0.16
chr6_166832217_166832454	0.28	RP1-168L15.5		35658	0.13
chr10_11236479_11236664	0.28	RP3-323N1.2		23232	0.2
chr5_133466460_133466611	0.28	TCF7	transcription factor 7 (T-cell specific, HMG-box)	7226	0.22
chrX_20264408_20264559	0.28	RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	4677	0.28
chr1_246984990_246985280	0.27	ENSG00000252011	.	11696	0.16
chr1_160832817_160833049	0.27	CD244	CD244 molecule, natural killer cell receptor 2B4	241	0.91
chr2_74248551_74248821	0.27	TET3	tet methylcytosine dioxygenase 3	18846	0.16
chr9_96930007_96930263	0.27	ENSG00000199165	.	8099	0.16
chr15_45879124_45879275	0.27	BLOC1S6	biogenesis of lysosomal organelles complex-1, subunit 6, pallidin	122	0.76
chr11_14269963_14270251	0.27	RP11-21L19.1		25130	0.22
chr14_99672150_99672346	0.27	AL162151.4		47495	0.14
chr12_102101528_102101679	0.27	CHPT1	choline phosphotransferase 1	10153	0.13
chr22_40571822_40572044	0.27	TNRC6B	trinucleotide repeat containing 6B	1996	0.43
chr6_47276688_47276935	0.27	TNFRSF21	tumor necrosis factor receptor superfamily, member 21	830	0.75
chr21_46271927_46272078	0.27	PTTG1IP	pituitary tumor-transforming 1 interacting protein	9846	0.13
chr21_45509719_45509870	0.27	PWP2	PWP2 periodic tryptophan protein homolog (yeast)	17377	0.16
chr5_175079178_175079630	0.27	HRH2	histamine receptor H2	5629	0.23
chr5_133426970_133427238	0.26	TCF7	transcription factor 7 (T-cell specific, HMG-box)	23298	0.2
chr10_30783764_30783915	0.26	MAP3K8	mitogen-activated protein kinase kinase kinase 8	56088	0.12
chr11_64560688_64561099	0.26	MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2	9754	0.11
chr17_38760477_38760676	0.26	SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	27966	0.12
chr1_162468126_162468277	0.26	UHMK1	U2AF homology motif (UHM) kinase 1	568	0.76
chr15_60864333_60864586	0.26	RORA	RAR-related orphan receptor A	20281	0.19
chr1_27118119_27118479	0.26	PIGV	phosphatidylinositol glycan anchor biosynthesis, class V	2880	0.17
chr11_67368212_67368440	0.26	RP11-655M14.12		4666	0.1
chr17_26940722_26940873	0.26	SGK494	uncharacterized serine/threonine-protein kinase SgK494	382	0.39
chr12_7252075_7252330	0.26	C1RL	complement component 1, r subcomponent-like	2479	0.15
chr2_12433970_12434170	0.26	ENSG00000264089	.	94814	0.09
chr4_154448725_154449000	0.26	KIAA0922	KIAA0922	28186	0.22
chr13_41054978_41055129	0.26	AL133318.1	Uncharacterized protein	56270	0.14
chr7_114566431_114566590	0.26	MDFIC	MyoD family inhibitor domain containing	3379	0.39
chr20_57828040_57828198	0.26	EDN3	endothelin 3	47363	0.15
chr7_797729_797880	0.26	HEATR2	HEAT repeat containing 2	10308	0.19
chr20_57699560_57699711	0.26	ZNF831	zinc finger protein 831	66440	0.1
chr3_31219913_31220076	0.26	ENSG00000265376	.	16715	0.26
chr16_79229427_79229578	0.26	ENSG00000222244	.	68849	0.11
chr15_60828599_60828948	0.26	CTD-2501E16.2		6601	0.21
chr12_9905866_9906017	0.26	CD69	CD69 molecule	7556	0.16
chr2_31360077_31360277	0.26	GALNT14	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	710	0.75
chr3_49907414_49907654	0.25	CAMKV	CaM kinase-like vesicle-associated	121	0.92
chr12_11694203_11694354	0.25	ENSG00000221128	.	701	0.69
chr4_109061717_109062040	0.25	LEF1	lymphoid enhancer-binding factor 1	25579	0.2
chr10_111846556_111846769	0.25	ADD3	adducin 3 (gamma)	78940	0.09
chr1_172612946_172613385	0.25	FASLG	Fas ligand (TNF superfamily, member 6)	14989	0.23
chr8_128751309_128751460	0.25	MYC	v-myc avian myelocytomatosis viral oncogene homolog	2907	0.36
chr17_4936150_4936301	0.25	SLC52A1	solute carrier family 52 (riboflavin transporter), member 1	2496	0.13
chr1_25947708_25947859	0.25	MAN1C1	mannosidase, alpha, class 1C, member 1	3442	0.25
chr10_134358490_134358742	0.25	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	6973	0.23
chr12_4257130_4257281	0.25	CCND2	cyclin D2	125733	0.05
chr11_128591622_128591949	0.25	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	25867	0.16
chr17_38720137_38720288	0.25	CCR7	chemokine (C-C motif) receptor 7	1499	0.37
chr17_75964850_75965001	0.25	TNRC6C	trinucleotide repeat containing 6C	35324	0.15
chr1_172673559_172674098	0.25	FASLG	Fas ligand (TNF superfamily, member 6)	45670	0.18
chr17_32291882_32292036	0.25	RP11-17M24.2		11591	0.2
chr2_198108993_198109144	0.25	ANKRD44	ankyrin repeat domain 44	46306	0.12
chr5_6485628_6485779	0.25	UBE2QL1	ubiquitin-conjugating enzyme E2Q family-like 1	36967	0.21
chr2_42533183_42533346	0.25	EML4	echinoderm microtubule associated protein like 4	4871	0.28
chr20_18269547_18269794	0.25	ZNF133	zinc finger protein 133	492	0.7
chr9_92070239_92070498	0.25	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	500	0.85
chr13_100024268_100024596	0.25	ENSG00000207719	.	16047	0.2
chr6_41990355_41990549	0.25	ENSG00000206875	.	4200	0.19
chr14_71788192_71788343	0.25	SIPA1L1	signal-induced proliferation-associated 1 like 1	159	0.64
chr10_73834893_73835167	0.25	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	13056	0.23
chr17_214026_214483	0.24	RP11-1260E13.3		9726	0.13
chr22_40333359_40333568	0.24	GRAP2	GRB2-related adaptor protein 2	9358	0.17
chr3_100113716_100113867	0.24	LNP1	leukemia NUP98 fusion partner 1	6246	0.2
chr11_118753286_118753582	0.24	CXCR5	chemokine (C-X-C motif) receptor 5	1041	0.35
chr18_67616654_67616805	0.24	CD226	CD226 molecule	1640	0.51
chr18_21445460_21445673	0.24	LAMA3	laminin, alpha 3	7238	0.23
chr6_41993033_41993209	0.24	ENSG00000206875	.	6869	0.17
chr6_34300867_34301037	0.24	NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	59499	0.1
chr8_38133631_38133782	0.24	RP11-513D5.5		300	0.85
chr20_31263204_31263355	0.24	COMMD7	COMM domain containing 7	67933	0.08
chr22_36555180_36555331	0.24	APOL3	apolipoprotein L, 3	1576	0.43

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF282

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0006530	asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.1	0.4	GO:0030091	protein repair(GO:0030091)
0.1	0.3	GO:0010040	response to iron(II) ion(GO:0010040)
0.1	0.3	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.3	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.1	0.2	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.1	0.3	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.2	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.1	0.2	GO:0060437	lung growth(GO:0060437)
0.1	0.2	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.1	GO:0033025	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.3	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.2	GO:0090036	regulation of protein kinase C signaling(GO:0090036) positive regulation of protein kinase C signaling(GO:0090037)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.2	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.1	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.2	GO:0002860	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.1	GO:1900120	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.1	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0	0.4	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.1	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.2	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.2	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0	0.1	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.3	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0002837	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0	0.1	GO:2000758	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0046512	diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.0	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0019532	oxalate transport(GO:0019532)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0002335	mature B cell differentiation(GO:0002335)
0.0	0.2	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0071243	cellular response to arsenic-containing substance(GO:0071243)
0.0	0.1	GO:0039656	modulation by virus of host gene expression(GO:0039656)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.0	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.1	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.1	GO:0021860	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.0	0.1	GO:0048535	lymph node development(GO:0048535)
0.0	0.3	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.1	GO:0042663	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.0	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.0	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.0	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.2	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:1904936	interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.0	0.0	GO:0071801	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0060206	estrous cycle phase(GO:0060206)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0016048	detection of temperature stimulus(GO:0016048)
0.0	0.2	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.1	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.0	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:2000258	negative regulation of humoral immune response(GO:0002921) negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.1	GO:0015074	DNA integration(GO:0015074)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.1	GO:0048143	astrocyte activation(GO:0048143)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.1	GO:0035624	receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.0	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.3	GO:0090630	activation of GTPase activity(GO:0090630)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.0	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.1	GO:0015840	urea transport(GO:0015840)
0.0	0.1	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.2	GO:0009086	methionine biosynthetic process(GO:0009086)
0.0	0.0	GO:0031062	positive regulation of histone methylation(GO:0031062)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.8	GO:0031294	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.1	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.0	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0	0.0	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.1	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.0	GO:0072177	mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
0.0	0.0	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.2	GO:0016558	protein import into peroxisome matrix(GO:0016558)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.0	GO:0031167	rRNA methylation(GO:0031167)
0.0	0.1	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.1	GO:0033523	histone H2B ubiquitination(GO:0033523)
0.0	0.1	GO:0060219	camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0014826	vein smooth muscle contraction(GO:0014826)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.1	GO:0048194	COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0	0.0	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.2	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.0	0.1	GO:0007035	vacuolar acidification(GO:0007035)
0.0	0.1	GO:0006356	regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.0	0.0	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.0	GO:0035268	protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0	0.6	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.1	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.1	GO:0030146	obsolete diuresis(GO:0030146)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.2	GO:0015804	neutral amino acid transport(GO:0015804)
0.0	0.0	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.1	GO:0071168	protein localization to chromatin(GO:0071168)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:2000257	regulation of complement activation(GO:0030449) regulation of protein activation cascade(GO:2000257)
0.0	0.1	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.1	GO:0006658	phosphatidylserine metabolic process(GO:0006658)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.2	GO:0051457	maintenance of protein location in nucleus(GO:0051457)
0.0	0.0	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.1	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.0	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.0	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.0	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.0	GO:0031116	positive regulation of microtubule polymerization(GO:0031116)
0.0	0.0	GO:0051971	positive regulation of transmission of nerve impulse(GO:0051971)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.0	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.0	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.0	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.2	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.0	GO:0032693	negative regulation of interleukin-10 production(GO:0032693)
0.0	0.1	GO:0009298	GDP-mannose biosynthetic process(GO:0009298)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.0	GO:0031507	heterochromatin assembly(GO:0031507) heterochromatin organization(GO:0070828)
0.0	0.0	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.0	GO:0060913	cardiac cell fate determination(GO:0060913)
0.0	0.0	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.1	GO:0006342	chromatin silencing(GO:0006342)
0.0	0.1	GO:0032986	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.2	GO:0001578	microtubule bundle formation(GO:0001578)
0.0	0.0	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0	0.2	GO:0050832	defense response to fungus(GO:0050832)
0.0	0.2	GO:0006084	acetyl-CoA metabolic process(GO:0006084)
0.0	0.0	GO:0071428	rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0	0.1	GO:2000279	negative regulation of DNA biosynthetic process(GO:2000279)
0.0	0.0	GO:0060413	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.1	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.1	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.0	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.0	0.1	GO:0033138	positive regulation of peptidyl-serine phosphorylation(GO:0033138)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005827	polar microtubule(GO:0005827)
0.0	0.3	GO:0045179	apical cortex(GO:0045179)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.2	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.5	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.3	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.3	GO:0001772	immunological synapse(GO:0001772)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.2	GO:0032838	cell projection cytoplasm(GO:0032838)
0.0	0.4	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.2	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.1	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.1	GO:0042583	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	0.0	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.3	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.0	0.6	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.0	GO:0033185	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.0	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.0	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.2	GO:0000314	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.2	GO:0043209	myelin sheath(GO:0043209)
0.0	0.0	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.4	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.1	GO:0030663	COPI-coated vesicle membrane(GO:0030663)
0.0	0.0	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	0.0	GO:0036126	outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0	0.1	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.1	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.1	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.0	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.2	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.1	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0	0.0	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.0	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1	0.3	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.2	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1	0.2	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.1	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.2	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.1	0.2	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.2	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.2	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.3	GO:0061630	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.1	GO:0004803	transposase activity(GO:0004803)
0.0	0.1	GO:0016160	alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.2	GO:0048156	tau protein binding(GO:0048156)
0.0	0.4	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.3	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0002060	purine nucleobase binding(GO:0002060)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.2	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.4	GO:0034979	NAD-dependent protein deacetylase activity(GO:0034979)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.2	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.2	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.2	GO:0017040	ceramidase activity(GO:0017040)
0.0	0.1	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.1	GO:0001848	complement binding(GO:0001848)
0.0	0.1	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0004476	mannose-6-phosphate isomerase activity(GO:0004476)
0.0	0.5	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	0.0	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0017089	glycolipid transporter activity(GO:0017089)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.4	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.3	GO:0043499	obsolete eukaryotic cell surface binding(GO:0043499)
0.0	0.1	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0004938	alpha-adrenergic receptor activity(GO:0004936) alpha2-adrenergic receptor activity(GO:0004938)
0.0	0.1	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.2	GO:0070888	E-box binding(GO:0070888)
0.0	0.0	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.0	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.2	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.6	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.0	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.1	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.0	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.0	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.3	GO:0016675	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0	0.0	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.1	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.2	GO:0015175	neutral amino acid transmembrane transporter activity(GO:0015175)
0.0	0.0	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.0	GO:0031781	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.1	GO:0016307	phosphatidylinositol phosphate kinase activity(GO:0016307) 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.0	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.0	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.0	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0	0.0	GO:0052866	phosphatidylinositol phosphate phosphatase activity(GO:0052866)
0.0	0.2	GO:0005035	death receptor activity(GO:0005035)
0.0	0.0	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.0	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.0	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.0	GO:0046980	tapasin binding(GO:0046980)
0.0	0.1	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.3	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.0	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.2	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.0	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.6	PID IL5 PATHWAY	IL5-mediated signaling events
0.6	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
1.6	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.5	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.3	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.6	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.2	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.1	PID CD40 PATHWAY	CD40/CD40L signaling
0.2	PID ALK2 PATHWAY	ALK2 signaling events
0.3	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.4	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.4	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.2	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.5	PID TNF PATHWAY	TNF receptor signaling pathway
0.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.1	PID IL3 PATHWAY	IL3-mediated signaling events
0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	PID BCR 5PATHWAY	BCR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.6	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.4	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.4	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.5	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.3	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.7	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.3	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.2	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.3	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.5	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.2	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.2	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.1	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.2	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.6	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.2	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	REACTOME DEADENYLATION DEPENDENT MRNA DECAY	Genes involved in Deadenylation-dependent mRNA decay
0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.4	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.3	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.1	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.1	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling