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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for ZNF35
Z-value: 4.01
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Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:
This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.
For each TF, only the top 5 correlated CREs are shown.
| CRE | Gene | Distance | Association probability | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|---|---|
| chr3_44689965_44690121 | ZNF35 | 176 | 0.923318 | 0.61 | 8.4e-02 | Click! |
| chr3_44690178_44690339 | ZNF35 | 21 | 0.965386 | 0.66 | 5.2e-02 | Click! |
| chr3_44690446_44690681 | ZNF35 | 326 | 0.835748 | 0.53 | 1.4e-01 | Click! |
| chr3_44690849_44691014 | ZNF35 | 694 | 0.584467 | -0.50 | 1.7e-01 | Click! |
Showing 1 to 4 of 4 entries
Top target CREs of the motif:
| Cis Regulatory Element (CRE) | Target Score | Top associated gene | Gene Info | Distance of CRE to TSS | CRE/Gene association probability |
|---|---|---|---|---|---|
| chr6_154478833_154479416 | 2.55 |
OPRM1 |
opioid receptor, mu 1 |
71482 |
0.12 |
| chr11_128601305_128601624 | 2.30 |
FLI1 |
Fli-1 proto-oncogene, ETS transcription factor |
33221 |
0.15 |
| chr14_31679082_31679233 | 1.66 |
HECTD1 |
HECT domain containing E3 ubiquitin protein ligase 1 |
2147 |
0.28 |
| chr20_2722949_2723333 | 1.64 |
EBF4 |
early B-cell factor 4 |
36254 |
0.09 |
| chr4_48133453_48133604 | 1.45 |
TXK |
TXK tyrosine kinase |
2745 |
0.23 |
| chrX_70337203_70337354 | 1.41 |
MED12 |
mediator complex subunit 12 |
1128 |
0.33 |
| chr10_6216160_6216311 | 1.35 |
ENSG00000263628 |
. |
22076 |
0.13 |
| chr4_40228763_40229105 | 1.33 |
RHOH |
ras homolog family member H |
26970 |
0.19 |
| chr4_122112223_122112496 | 1.32 |
ENSG00000252183 |
. |
1699 |
0.43 |
| chr3_153341996_153342169 | 1.32 |
ENSG00000200162 |
. |
16916 |
0.27 |
Histogram of CRE-TSS distances for CREs targeted by :
Rank distribution of CRE target scores:
Distribution of target CREs across different genomic regions:
Network of associatons between targets according to the STRING database.
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.0 | 4.0 | GO:0016071 | mRNA metabolic process(GO:0016071) |
| 0.1 | 2.9 | GO:0072431 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in cell cycle checkpoint(GO:0072395) signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in mitotic cell cycle checkpoint(GO:0072413) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400) signal transduction involved in mitotic DNA damage checkpoint(GO:1902402) signal transduction involved in mitotic DNA integrity checkpoint(GO:1902403) |
| 0.0 | 2.7 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.0 | 2.4 | GO:0018196 | peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.3 | 2.0 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.0 | 1.8 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.1 | 1.6 | GO:0046834 | lipid phosphorylation(GO:0046834) |
| 0.0 | 1.6 | GO:0016568 | chromatin modification(GO:0016568) |
| 0.0 | 1.5 | GO:0022904 | respiratory electron transport chain(GO:0022904) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 33.5 | GO:0005634 | nucleus(GO:0005634) |
| 0.0 | 14.5 | GO:0005829 | cytosol(GO:0005829) |
| 0.0 | 2.6 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 2.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 2.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 2.3 | GO:0005625 | obsolete soluble fraction(GO:0005625) |
| 0.1 | 2.2 | GO:0005626 | obsolete insoluble fraction(GO:0005626) |
| 0.0 | 2.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 2.0 | GO:0000785 | chromatin(GO:0000785) |
| 0.2 | 1.9 | GO:0001891 | phagocytic cup(GO:0001891) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.1 | GO:0003723 | RNA binding(GO:0003723) |
| 0.0 | 4.8 | GO:0016563 | obsolete transcription activator activity(GO:0016563) |
| 0.1 | 2.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 2.6 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.0 | 2.6 | GO:0030528 | obsolete transcription regulator activity(GO:0030528) |
| 0.1 | 2.5 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 2.3 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 2.3 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 2.1 | GO:0042393 | histone binding(GO:0042393) |
| 0.2 | 2.0 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 3.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 3.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 2.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 2.1 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.1 | 2.0 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 1.7 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.7 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 1.5 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 3.2 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.0 | 2.9 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.1 | 2.6 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 2.4 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 0.0 | 2.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 1.9 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 1.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 1.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 1.8 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |