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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZNF410

Z-value: 0.50

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Transcription factors associated with ZNF410

Gene Symbol	Gene ID	Gene Info
ZNF410 Ensembl NCBI GeneCards UniProt	ENSG00000119725.13	ZNF410

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZNF410	chr14_74366133_74366284	4195	0.118388	0.68	4.4e-02	Click!
ZNF410	chr14_74366502_74366653	3826	0.122332	0.63	6.6e-02	Click!
ZNF410	chr14_74352029_74352386	1113	0.340434	-0.57	1.1e-01	Click!
ZNF410	chr14_74355053_74355205	1368	0.274815	0.43	2.5e-01	Click!
ZNF410	chr14_74356161_74356312	2317	0.170419	0.40	2.8e-01	Click!

Activity of the ZNF410 motif across conditions

Conditions sorted by the z-value of the ZNF410 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_6716949_6717188	0.35	CHD4	chromodomain helicase DNA binding protein 4	426	0.66
chr12_6717224_6717396	0.35	CHD4	chromodomain helicase DNA binding protein 4	668	0.47
chr3_99801308_99801543	0.32	FILIP1L	filamin A interacting protein 1-like	31932	0.17
chr2_56115946_56116097	0.28	EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	34335	0.17
chr11_15179125_15179276	0.27	INSC	inscuteable homolog (Drosophila)	8546	0.3
chr3_30538477_30538630	0.26	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	109441	0.07
chr2_33329316_33329467	0.26	LTBP1	latent transforming growth factor beta binding protein 1	30082	0.23
chr6_140372368_140372519	0.26	ENSG00000252107	.	107388	0.08
chr5_88733052_88733203	0.24	MEF2C-AS1	MEF2C antisense RNA 1	18503	0.3
chr15_58734161_58734312	0.24	LIPC	lipase, hepatic	10046	0.2
chr3_40151249_40151400	0.24	MYRIP	myosin VIIA and Rab interacting protein	9822	0.27
chr11_74561231_74561382	0.24	ENSG00000242999	.	4351	0.2
chr12_29196725_29196876	0.23	ENSG00000222481	.	77015	0.11
chr7_77200209_77200424	0.23	PTPN12	protein tyrosine phosphatase, non-receptor type 12	92	0.98
chr10_111659026_111659177	0.23	XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	8476	0.22
chr8_30309779_30309930	0.23	RBPMS	RNA binding protein with multiple splicing	9721	0.26
chr16_53246810_53247380	0.23	CHD9	chromodomain helicase DNA binding protein 9	4732	0.24
chr12_81172448_81172599	0.22	ENSG00000207763	.	53885	0.12
chr12_46776255_46776796	0.22	SLC38A2	solute carrier family 38, member 2	9875	0.24
chr18_20945112_20945263	0.21	TMEM241	transmembrane protein 241	72630	0.09
chr1_68306464_68306615	0.21	GNG12	guanine nucleotide binding protein (G protein), gamma 12	7389	0.22
chr5_9194903_9195054	0.21	SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	70679	0.13
chr1_55012899_55013050	0.21	ACOT11	acyl-CoA thioesterase 11	927	0.55
chr9_87838634_87838879	0.21	AGTPBP1	ATP/GTP binding protein 1	457445	0.01
chr3_190245134_190245536	0.21	IL1RAP	interleukin 1 receptor accessory protein	13444	0.26
chr17_54262776_54262927	0.20	ANKFN1	ankyrin-repeat and fibronectin type III domain containing 1	11315	0.31
chr1_33629505_33629812	0.20	TRIM62	tripartite motif containing 62	12493	0.21
chr1_179148308_179148459	0.20	ENSG00000212338	.	17225	0.17
chr8_26206285_26206436	0.20	BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	34054	0.17
chrX_16661091_16661259	0.20	S100G	S100 calcium binding protein G	7106	0.18
chr7_34022267_34022418	0.20	BMPER	BMP binding endothelial regulator	77197	0.12
chr3_99997916_99998067	0.19	TBC1D23	TBC1 domain family, member 23	293	0.91
chr11_5385191_5385342	0.19	OR51B6	olfactory receptor, family 51, subfamily B, member 6	12528	0.1
chr1_204395036_204395187	0.18	PPP1R15B	protein phosphatase 1, regulatory subunit 15B	14192	0.17
chr1_95219154_95219305	0.18	ENSG00000263526	.	7773	0.26
chr15_40234024_40234175	0.18	EIF2AK4	eukaryotic translation initiation factor 2 alpha kinase 4	7722	0.15
chr3_57018939_57019090	0.18	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	7611	0.23
chr1_28466094_28466257	0.18	ENSG00000253005	.	3177	0.17
chr3_101555850_101556001	0.18	NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	9088	0.19
chr13_21654358_21654593	0.17	LATS2	large tumor suppressor kinase 2	18789	0.14
chr20_31332968_31333119	0.17	COMMD7	COMM domain containing 7	1240	0.47
chr10_97039069_97039220	0.17	PDLIM1	PDZ and LIM domain 1	11637	0.23
chr14_29751933_29752084	0.17	ENSG00000257522	.	95854	0.09
chr2_3495267_3495450	0.16	TRAPPC12-AS1	TRAPPC12 antisense RNA 1	9178	0.14
chr6_157610859_157611010	0.16	ENSG00000252609	.	101497	0.07
chr7_13920146_13920297	0.16	ETV1	ets variant 1	105845	0.08
chr10_98460620_98460814	0.16	PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	19554	0.19
chr5_14154581_14154957	0.16	TRIO	trio Rho guanine nucleotide exchange factor	10940	0.32
chr6_47010736_47010893	0.16	GPR110	G protein-coupled receptor 110	715	0.78
chr3_115155334_115155485	0.16	GAP43	growth associated protein 43	186762	0.03
chr14_35097827_35098332	0.15	SNX6	sorting nexin 6	799	0.64
chr2_221144537_221144688	0.15	ENSG00000221199	.	88013	0.1
chr6_132720652_132720803	0.15	MOXD1	monooxygenase, DBH-like 1	1887	0.45
chr4_77577306_77577457	0.15	AC107072.2		18605	0.2
chr5_57591370_57591521	0.14	PLK2	polo-like kinase 2	164642	0.04
chr2_201612308_201612459	0.14	ENSG00000201737	.	27924	0.13
chr5_36725188_36725339	0.14	CTD-2353F22.1		12	0.99
chr10_15834401_15834552	0.14	FAM188A	family with sequence similarity 188, member A	25531	0.23
chr10_78046565_78046716	0.14	ENSG00000201954	.	25979	0.18
chr16_70031993_70032144	0.14	RP11-419C5.2		1977	0.28
chr9_117077655_117077806	0.14	ORM1	orosomucoid 1	7606	0.19
chr2_152213518_152213794	0.13	TNFAIP6	tumor necrosis factor, alpha-induced protein 6	450	0.8
chr1_211770661_211771027	0.13	RP11-359E8.5		13777	0.17
chr2_75122030_75122181	0.13	HK2	hexokinase 2	59808	0.12
chr17_36862672_36863533	0.13	CTB-58E17.3		588	0.44
chr14_55088387_55088538	0.13	SAMD4A	sterile alpha motif domain containing 4A	53825	0.15
chr8_19521264_19521461	0.13	CSGALNACT1	chondroitin sulfate N-acetylgalactosaminyltransferase 1	18732	0.28
chr1_229118656_229118807	0.12	RP5-1061H20.5		244578	0.01
chr6_73298808_73298959	0.12	KCNQ5	potassium voltage-gated channel, KQT-like subfamily, member 5	32637	0.2
chr12_13074467_13074618	0.12	ENSG00000207817	.	5779	0.13
chr4_88727397_88727610	0.12	IBSP	integrin-binding sialoprotein	6770	0.18
chr12_6722253_6722786	0.12	CHD4	chromodomain helicase DNA binding protein 4	5877	0.09
chr20_45928695_45928846	0.12	ZMYND8	zinc finger, MYND-type containing 8	1126	0.41
chr4_7907002_7907153	0.12	AFAP1	actin filament associated protein 1	33037	0.16
chr9_80211377_80211528	0.12	ENSG00000201711	.	38773	0.19
chr20_25506429_25506580	0.12	NINL	ninein-like	46841	0.14
chr3_156266075_156266226	0.12	SSR3	signal sequence receptor, gamma (translocon-associated protein gamma)	5764	0.24
chr13_25485161_25485312	0.11	CENPJ	centromere protein J	7104	0.24
chr16_14839837_14839988	0.11	RP11-719K4.6		122	0.94
chr16_14800717_14800868	0.11	RP11-82O18.2		120	0.93
chr3_100235412_100235563	0.11	TMEM45A	transmembrane protein 45A	23983	0.21
chr6_88457610_88457792	0.11	ENSG00000238628	.	27068	0.17
chr5_142254524_142254675	0.11	ARHGAP26-AS1	ARHGAP26 antisense RNA 1	6112	0.27
chr5_32841630_32841781	0.10	AC026703.1		52760	0.15
chr2_15370019_15370258	0.10	NBAS	neuroblastoma amplified sequence	8672	0.33
chr10_24753767_24753918	0.10	KIAA1217	KIAA1217	1618	0.45
chr5_163628955_163629106	0.10	CTC-340A15.2		94672	0.1
chrX_24073482_24074722	0.10	EIF2S3	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	1014	0.57
chr8_125815205_125815550	0.10	ENSG00000263735	.	18923	0.24
chr9_129811608_129811922	0.10	ANGPTL2	angiopoietin-like 2	73148	0.1
chr8_70091869_70092020	0.10	ENSG00000238808	.	69135	0.14
chr16_81779154_81779305	0.10	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	6527	0.3
chr8_103938601_103938752	0.10	ENSG00000201216	.	24116	0.13
chrX_123403964_123404115	0.10	ENSG00000252693	.	72446	0.11
chr20_36629780_36630040	0.09	TTI1	TELO2 interacting protein 1	12395	0.17
chr3_67559756_67559907	0.09	SUCLG2	succinate-CoA ligase, GDP-forming, beta subunit	18815	0.3
chr12_6717643_6717941	0.09	CHD4	chromodomain helicase DNA binding protein 4	1150	0.27
chr17_35854791_35854942	0.09	DUSP14	dual specificity phosphatase 14	3296	0.25
chr7_133373225_133373376	0.09	EXOC4	exocyst complex component 4	112084	0.07
chr10_103608566_103608725	0.09	KCNIP2	Kv channel interacting protein 2	4968	0.18
chr11_109983287_109983623	0.09	ZC3H12C	zinc finger CCCH-type containing 12C	18274	0.29
chr1_42312204_42312355	0.09	HIVEP3	human immunodeficiency virus type I enhancer binding protein 3	71890	0.12
chr6_21610679_21610963	0.09	SOX4	SRY (sex determining region Y)-box 4	16750	0.31
chr2_1629536_1629687	0.09	AC144450.1		5726	0.29
chr1_159065750_159065901	0.09	AIM2	absent in melanoma 2	19134	0.17
chr5_39460419_39460570	0.09	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	1908	0.49
chr15_101726120_101726271	0.08	CHSY1	chondroitin sulfate synthase 1	65942	0.1
chr7_94327256_94327407	0.08	ENSG00000239030	.	14390	0.2
chr17_1356696_1356953	0.08	CRK	v-crk avian sarcoma virus CT10 oncogene homolog	2619	0.21
chr9_132977954_132978121	0.08	NCS1	neuronal calcium sensor 1	15165	0.22
chr17_73872544_73873300	0.08	TRIM47	tripartite motif containing 47	423	0.43
chr1_36751423_36751675	0.08	SH3D21	SH3 domain containing 21	20439	0.13
chr1_212421007_212421158	0.08	PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	37797	0.14
chr1_150188550_150188701	0.08	ENSG00000266187	.	4695	0.12
chr1_84764836_84765174	0.08	SAMD13	sterile alpha motif domain containing 13	236	0.94
chr6_147534808_147534959	0.08	STXBP5	syntaxin binding protein 5 (tomosyn)	7773	0.25
chr3_71574289_71574598	0.08	ENSG00000221264	.	16797	0.2
chr10_30573247_30573398	0.08	ENSG00000200887	.	15280	0.19
chr6_135857036_135857769	0.08	AHI1	Abelson helper integration site 1	38488	0.19
chr5_141695794_141696287	0.08	SPRY4	sprouty homolog 4 (Drosophila)	7707	0.23
chr9_81312837_81312988	0.08	PSAT1	phosphoserine aminotransferase 1	400853	0.01
chr6_48103867_48104018	0.08	PTCHD4	patched domain containing 4	67517	0.14
chr15_71571317_71571468	0.08	RP11-592N21.2		63271	0.13
chr6_87836746_87836897	0.08	ZNF292	zinc finger protein 292	25730	0.15
chr7_30405754_30405905	0.08	GS1-114I9.1		58459	0.11
chr6_88407042_88408017	0.08	AKIRIN2	akirin 2	4398	0.23
chr22_31985004_31985155	0.08	SFI1	Sfi1 homolog, spindle assembly associated (yeast)	5187	0.21
chr3_119631372_119631523	0.07	NR1I2	nuclear receptor subfamily 1, group I, member 2	129890	0.05
chr15_52788876_52789027	0.07	MYO5A	myosin VA (heavy chain 12, myoxin)	32087	0.18
chr9_7912412_7912563	0.07	TMEM261	transmembrane protein 261	112420	0.08
chr11_128659981_128660132	0.07	FLI1	Fli-1 proto-oncogene, ETS transcription factor	25371	0.18
chr6_141057887_141058038	0.07	ENSG00000264390	.	53011	0.17
chr6_151384328_151384479	0.07	RP1-292B18.3		7210	0.2
chr4_54948926_54949077	0.07	GSX2	GS homeobox 2	17197	0.14
chr7_139427311_139427656	0.07	HIPK2	homeodomain interacting protein kinase 2	5642	0.28
chr19_2042508_2043083	0.07	MKNK2	MAP kinase interacting serine/threonine kinase 2	163	0.91
chr1_225942912_225943116	0.07	ENSG00000223306	.	14037	0.14
chr6_150949013_150949164	0.07	RP11-136K14.2		3275	0.27
chr10_86095698_86095849	0.07	CCSER2	coiled-coil serine-rich protein 2	7354	0.26
chr8_134089052_134089395	0.07	SLA	Src-like-adaptor	16620	0.22
chr17_13766234_13766385	0.07	ENSG00000236088	.	29847	0.25
chr8_4852979_4853130	0.07	CSMD1	CUB and Sushi multiple domains 1	560	0.86
chr6_84228850_84229001	0.07	PRSS35	protease, serine, 35	6668	0.28
chr1_56839712_56839863	0.07	ENSG00000223307	.	3303	0.39
chr21_36879615_36879766	0.07	ENSG00000211590	.	213323	0.02
chr2_55346845_55347305	0.07	RTN4	reticulon 4	7318	0.2
chrX_16051396_16051547	0.07	GRPR	gastrin-releasing peptide receptor	90208	0.08
chr7_95239146_95239504	0.07	AC002451.3		217	0.94
chr12_88718394_88718545	0.07	ENSG00000199245	.	105750	0.07
chr3_29294214_29294365	0.06	RBMS3	RNA binding motif, single stranded interacting protein 3	28184	0.21
chr3_128958402_128958654	0.06	COPG1	coatomer protein complex, subunit gamma 1	9921	0.15
chr3_69840030_69840181	0.06	ENSG00000241665	.	21177	0.22
chr19_13023555_13024013	0.06	SYCE2	synaptonemal complex central element protein 2	6306	0.06
chr10_101753173_101753324	0.06	DNMBP	dynamin binding protein	16428	0.18
chr5_9016573_9016856	0.06	CTD-2215L10.1		14828	0.25
chr6_133281352_133281503	0.06	ENSG00000200534	.	143069	0.04
chr5_111498551_111498743	0.06	ENSG00000238363	.	1465	0.41
chr10_35006283_35006434	0.06	PARD3	par-3 family cell polarity regulator	97891	0.08
chr16_53290719_53290870	0.06	ENSG00000212582	.	5959	0.22
chr18_12409679_12409882	0.06	SLMO1	slowmo homolog 1 (Drosophila)	1836	0.3
chr2_201270022_201270173	0.06	SPATS2L	spermatogenesis associated, serine-rich 2-like	12297	0.18
chr7_100798830_100799198	0.06	AP1S1	adaptor-related protein complex 1, sigma 1 subunit	1208	0.28
chr11_79125207_79125358	0.06	ENSG00000266570	.	7988	0.21
chr12_13500086_13500237	0.06	C12orf36	chromosome 12 open reading frame 36	29203	0.21
chr7_134584974_134585125	0.06	CALD1	caldesmon 1	8688	0.28
chr12_121727254_121727405	0.06	CAMKK2	calcium/calmodulin-dependent protein kinase kinase 2, beta	7160	0.21
chr1_94371593_94371744	0.06	GCLM	glutamate-cysteine ligase, modifier subunit	3298	0.25
chr10_121572117_121572268	0.06	INPP5F	inositol polyphosphate-5-phosphatase F	6036	0.23
chr8_130334106_130334257	0.06	ENSG00000222755	.	30952	0.22
chr3_131104607_131104908	0.06	NUDT16	nudix (nucleoside diphosphate linked moiety X)-type motif 16	4128	0.2
chr7_127421938_127422089	0.06	SND1	staphylococcal nuclease and tudor domain containing 1	105952	0.06
chr14_32842058_32842209	0.05	AKAP6	A kinase (PRKA) anchor protein 6	43527	0.15
chr12_109118549_109119150	0.05	CORO1C	coronin, actin binding protein, 1C	5478	0.17
chr14_68633954_68634105	0.05	ENSG00000244677	.	17404	0.22
chr4_129375310_129375461	0.05	PGRMC2	progesterone receptor membrane component 2	165401	0.04
chr11_10064252_10064435	0.05	SBF2	SET binding factor 2	49692	0.16
chr1_234641581_234641923	0.05	TARBP1	TAR (HIV-1) RNA binding protein 1	26903	0.19
chr12_69743933_69744084	0.05	LYZ	lysozyme	1842	0.3
chr11_114034689_114034840	0.05	ENSG00000221112	.	77113	0.09
chr18_56237913_56238064	0.05	RP11-126O1.2		13686	0.16
chr6_74498861_74499012	0.05	RP11-553A21.3		93082	0.08
chr6_15389566_15390143	0.05	JARID2	jumonji, AT rich interactive domain 2	11235	0.25
chr1_12674943_12675094	0.05	DHRS3	dehydrogenase/reductase (SDR family) member 3	2719	0.25
chr19_45981127_45981279	0.05	ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)	883	0.43
chr8_52863208_52863359	0.05	RP11-110G21.1		50989	0.13
chr18_10269485_10269636	0.05	ENSG00000239031	.	120437	0.06
chr17_40388027_40388178	0.05	RP11-358B23.5		32503	0.08
chr10_116474466_116474617	0.05	ABLIM1	actin binding LIM protein 1	30127	0.21
chr1_113166689_113166984	0.05	ST7L	suppression of tumorigenicity 7 like	4796	0.14
chr9_95355824_95355975	0.05	CENPP	centromere protein P	6640	0.21
chr2_36364447_36364598	0.04	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	218547	0.02
chr17_8870824_8871109	0.04	PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	1942	0.4
chr5_149185316_149185608	0.04	PPARGC1B	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	27116	0.17
chr14_24611105_24611656	0.04	EMC9	ER membrane protein complex subunit 9	583	0.43
chr10_114673586_114673994	0.04	RP11-57H14.3		25296	0.18
chr11_36622535_36622686	0.04	RAG2	recombination activating gene 2	2824	0.27
chr16_86623972_86624123	0.04	FOXL1	forkhead box L1	11932	0.17
chr21_30691484_30691635	0.04	BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	7891	0.19
chr8_131269264_131269415	0.04	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	10051	0.29
chr1_81659170_81659383	0.04	ENSG00000223026	.	58198	0.16

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF410

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Total log-likelihood	Term	Description
0.1	GO:0035583	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0090568	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1	GO:0004500	dopamine beta-monooxygenase activity(GO:0004500)
0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.4	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1	GO:0047617	acyl-CoA hydrolase activity(GO:0047617)