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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZNF423

Z-value: 1.27

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Transcription factors associated with ZNF423

Gene Symbol	Gene ID	Gene Info
ZNF423 Ensembl NCBI GeneCards UniProt	ENSG00000102935.7	ZNF423

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZNF423	chr16_49890174_49890551	316	0.923061	0.86	3.0e-03	Click!
ZNF423	chr16_49891743_49892055	69	0.981476	0.75	2.0e-02	Click!
ZNF423	chr16_49892831_49893014	1092	0.601079	0.73	2.4e-02	Click!
ZNF423	chr16_49683940_49684091	9252	0.251366	-0.73	2.5e-02	Click!
ZNF423	chr16_49892506_49892687	766	0.728454	0.71	3.1e-02	Click!

Activity of the ZNF423 motif across conditions

Conditions sorted by the z-value of the ZNF423 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_25886127_25886448	0.73	LDLRAP1	low density lipoprotein receptor adaptor protein 1	16216	0.19
chr16_68109101_68109477	0.70	NFATC3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	9958	0.1
chr16_89521002_89521377	0.65	ENSG00000252887	.	11463	0.12
chr19_19737216_19737375	0.60	LPAR2	lysophosphatidic acid receptor 2	1314	0.3
chr16_85481767_85482285	0.59	ENSG00000264203	.	6928	0.27
chr1_117303582_117303773	0.55	CD2	CD2 molecule	6588	0.23
chr5_133440168_133440408	0.55	TCF7	transcription factor 7 (T-cell specific, HMG-box)	10114	0.23
chr17_45277609_45277834	0.52	MYL4	myosin, light chain 4, alkali; atrial, embryonic	8680	0.12
chr16_31477943_31478110	0.51	TGFB1I1	transforming growth factor beta 1 induced transcript 1	4880	0.1
chr9_130473685_130473878	0.50	C9orf117	chromosome 9 open reading frame 117	388	0.73
chr15_44969737_44969888	0.50	PATL2	protein associated with topoisomerase II homolog 2 (yeast)	726	0.6
chr14_99673860_99674011	0.49	AL162151.4		49182	0.14
chr6_20206050_20206262	0.49	RP11-239H6.2		6162	0.24
chr11_75220135_75220483	0.47	RP11-939C17.4		873	0.54
chr2_28647839_28647990	0.46	RP11-373D23.2		28232	0.14
chr14_94422859_94423119	0.46	ASB2	ankyrin repeat and SOCS box containing 2	778	0.58
chr2_173090506_173090657	0.46	ENSG00000238572	.	69733	0.11
chr4_153033286_153033437	0.46	ENSG00000266244	.	116259	0.06
chr17_75842366_75842622	0.46	FLJ45079		36165	0.19
chr20_61639034_61639185	0.46	BHLHE23	basic helix-loop-helix family, member e23	722	0.67
chr22_19585555_19585986	0.44	CLDN5	claudin 5	70702	0.08
chr1_9776346_9776497	0.44	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	1706	0.34
chr1_25345075_25345361	0.44	ENSG00000264371	.	4776	0.25
chr21_43579719_43579870	0.44	ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1	40005	0.13
chr16_89762519_89762771	0.42	SPATA2L	spermatogenesis associated 2-like	5403	0.1
chr3_51718621_51718776	0.42	ENSG00000201595	.	9900	0.15
chr22_46769711_46769909	0.42	TRMU	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase	37991	0.15
chr2_235333773_235334004	0.41	ARL4C	ADP-ribosylation factor-like 4C	71356	0.13
chr14_91832903_91833121	0.41	ENSG00000265856	.	32955	0.17
chr14_105662119_105662372	0.40	NUDT14	nudix (nucleoside diphosphate linked moiety X)-type motif 14	14605	0.15
chr19_54609905_54610056	0.40	NDUFA3	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa	708	0.42
chr3_169583062_169583383	0.40	LRRC31	leucine rich repeat containing 31	4399	0.16
chr17_37832739_37832926	0.40	PNMT	phenylethanolamine N-methyltransferase	8116	0.1
chr22_31289621_31289772	0.39	OSBP2	oxysterol binding protein 2	468	0.8
chr5_9544937_9545108	0.39	SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	1165	0.47
chr4_2792015_2792228	0.39	SH3BP2	SH3-domain binding protein 2	2629	0.29
chr5_67579614_67579808	0.39	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	3576	0.36
chr1_777188_777339	0.39	RP11-206L10.8		31722	0.11
chr1_200856866_200857017	0.39	C1orf106	chromosome 1 open reading frame 106	3235	0.23
chr19_54378263_54378435	0.39	AC008440.5		954	0.29
chr4_2836679_2837097	0.39	ADD1	adducin 1 (alpha)	8696	0.19
chr11_68597072_68597223	0.39	CPT1A	carnitine palmitoyltransferase 1A (liver)	10005	0.2
chr15_69101431_69101582	0.38	ENSG00000265195	.	7242	0.23
chr1_117453586_117453737	0.38	PTGFRN	prostaglandin F2 receptor inhibitor	982	0.54
chr2_70336914_70337228	0.38	PCBP1-AS1	PCBP1 antisense RNA 1	21093	0.14
chr12_108963200_108963590	0.38	ISCU	iron-sulfur cluster assembly enzyme	7009	0.15
chr9_134127671_134127998	0.37	FAM78A	family with sequence similarity 78, member A	18046	0.15
chr19_30160205_30160356	0.37	PLEKHF1	pleckstrin homology domain containing, family F (with FYVE domain) member 1	2499	0.33
chr1_92931900_92932072	0.37	GFI1	growth factor independent 1 transcription repressor	17525	0.23
chr1_203291434_203291646	0.37	ENSG00000202300	.	3313	0.22
chr8_134508972_134509123	0.37	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	2557	0.42
chr6_167505175_167505326	0.37	CCR6	chemokine (C-C motif) receptor 6	20045	0.18
chr10_30985837_30986131	0.37	SVILP1	supervillin pseudogene 1	1134	0.61
chr2_46118370_46118521	0.37	PRKCE	protein kinase C, epsilon	109596	0.07
chr11_62408838_62409025	0.37	GANAB	glucosidase, alpha; neutral AB	5150	0.06
chr6_15318009_15318227	0.37	ENSG00000201367	.	2967	0.27
chr1_42271688_42271993	0.36	ENSG00000264896	.	47028	0.18
chr20_62475435_62475724	0.36	AL158091.1	Protein LOC100509861	306	0.78
chr12_123571415_123571566	0.36	PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2	5610	0.2
chr2_127976471_127976630	0.35	CYP27C1	cytochrome P450, family 27, subfamily C, polypeptide 1	1104	0.58
chr21_46900861_46901012	0.35	COL18A1	collagen, type XVIII, alpha 1	9253	0.2
chr10_12589202_12589377	0.35	ENSG00000263584	.	31463	0.2
chr1_1105743_1105894	0.35	ENSG00000198976	.	1433	0.19
chr17_45780207_45780358	0.34	TBKBP1	TBK1 binding protein 1	7652	0.14
chr1_234306113_234306370	0.34	SLC35F3	solute carrier family 35, member F3	43776	0.14
chrX_128902828_128903127	0.34	SASH3	SAM and SH3 domain containing 3	10983	0.19
chr9_92445291_92445531	0.34	GADD45G	growth arrest and DNA-damage-inducible, gamma	225458	0.02
chr1_42106059_42106288	0.34	HIVEP3	human immunodeficiency virus type I enhancer binding protein 3	60499	0.13
chr9_92111235_92111454	0.34	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	1003	0.5
chr1_167656783_167656934	0.34	MPZL1	myelin protein zero-like 1	34329	0.16
chr4_1617642_1617793	0.33	FAM53A	family with sequence similarity 53, member A	39418	0.14
chr5_169687872_169688139	0.33	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	6295	0.24
chr16_88770397_88770548	0.33	RNF166	ring finger protein 166	447	0.59
chr7_20370436_20370587	0.33	ITGB8	integrin, beta 8	186	0.88
chr1_54844897_54845115	0.33	SSBP3	single stranded DNA binding protein 3	26171	0.19
chr9_107877201_107877485	0.33	ENSG00000201583	.	18306	0.27
chr11_65385759_65385910	0.33	PCNXL3	pecanex-like 3 (Drosophila)	2590	0.11
chr1_112020736_112021030	0.33	C1orf162	chromosome 1 open reading frame 162	4392	0.12
chr9_134458873_134459024	0.33	RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	38277	0.13
chr21_45334011_45334235	0.33	AGPAT3	1-acylglycerol-3-phosphate O-acyltransferase 3	2030	0.3
chr17_72459036_72459537	0.33	CD300A	CD300a molecule	3269	0.19
chr11_117821389_117821783	0.33	TMPRSS13	transmembrane protease, serine 13	21412	0.15
chr6_158993933_158994198	0.33	TMEM181	transmembrane protein 181	36597	0.15
chr7_138777169_138777799	0.32	ZC3HAV1	zinc finger CCCH-type, antiviral 1	13471	0.2
chr9_95825508_95825700	0.32	SUSD3	sushi domain containing 3	4543	0.2
chr11_1606465_1606821	0.32	KRTAP5-1	keratin associated protein 5-1	130	0.93
chr3_187767301_187767602	0.32	LPP	LIM domain containing preferred translocation partner in lipoma	103621	0.07
chr10_29776432_29776729	0.32	SVIL	supervillin	8867	0.24
chr22_30693041_30693254	0.32	RP1-130H16.18	Uncharacterized protein	2324	0.16
chr14_98459359_98459510	0.32	C14orf64	chromosome 14 open reading frame 64	14973	0.31
chr15_70825685_70825836	0.32	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	168860	0.04
chr1_167570557_167570959	0.32	RCSD1	RCSD domain containing 1	28572	0.15
chr8_128994096_128994247	0.32	ENSG00000207110	.	17206	0.16
chr20_1677648_1677799	0.32	ENSG00000242348	.	30717	0.14
chr6_125666901_125667052	0.32	RP11-735G4.1		28494	0.21
chr7_102072492_102072712	0.32	ORAI2	ORAI calcium release-activated calcium modulator 2	951	0.34
chr2_99077021_99077380	0.32	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	15787	0.23
chr5_154193336_154193487	0.31	LARP1	La ribonucleoprotein domain family, member 1	9630	0.16
chr21_19152626_19152837	0.31	AL109761.5		13074	0.23
chr8_97165985_97166258	0.31	GDF6	growth differentiation factor 6	6899	0.26
chr17_73234704_73234855	0.31	GGA3	golgi-associated, gamma adaptin ear containing, ARF binding protein 3	287	0.81
chr9_36143975_36144155	0.31	GLIPR2	GLI pathogenesis-related 2	7323	0.19
chr1_2426510_2426661	0.31	RP3-395M20.3		667	0.51
chr6_24866477_24866656	0.31	FAM65B	family with sequence similarity 65, member B	10975	0.19
chr1_204450638_204450997	0.31	PIK3C2B	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	8629	0.19
chr20_39774881_39775244	0.31	RP1-1J6.2		8419	0.2
chr17_76115212_76115363	0.30	TMC6	transmembrane channel-like 6	3542	0.15
chr22_29215628_29215779	0.30	CTA-292E10.6		1384	0.35
chr1_118195260_118195411	0.30	ENSG00000212266	.	36029	0.17
chr1_183440737_183440894	0.30	SMG7	SMG7 nonsense mediated mRNA decay factor	691	0.73
chr20_47239118_47239269	0.30	ENSG00000238452	.	116638	0.06
chr7_4792903_4793054	0.30	FOXK1	forkhead box K1	12488	0.16
chr19_42398087_42398358	0.30	ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	143	0.93
chr15_29382386_29382685	0.30	APBA2	amyloid beta (A4) precursor protein-binding, family A, member 2	46008	0.17
chr10_135076415_135076765	0.30	ADAM8	ADAM metallopeptidase domain 8	13764	0.09
chr20_55975873_55976024	0.30	RP4-800J21.3		7830	0.16
chr17_45782038_45782291	0.30	TBKBP1	TBK1 binding protein 1	9534	0.13
chr18_21200887_21201038	0.30	ANKRD29	ankyrin repeat domain 29	28524	0.15
chr14_101109543_101109694	0.30	CTD-2644I21.1		53955	0.07
chr9_127120006_127120171	0.30	ENSG00000264237	.	7278	0.21
chr7_1104722_1104898	0.29	RP11-449P15.1		5913	0.1
chr7_49814485_49814636	0.29	VWC2	von Willebrand factor C domain containing 2	1303	0.63
chr16_67795135_67795286	0.29	RP11-167P11.2		21385	0.1
chr21_46333137_46333552	0.29	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	854	0.44
chr5_176802584_176802735	0.29	SLC34A1	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	3577	0.12
chr14_91849387_91849607	0.29	CCDC88C	coiled-coil domain containing 88C	34193	0.17
chr6_139494692_139494843	0.29	HECA	headcase homolog (Drosophila)	38518	0.17
chr15_81588541_81588692	0.28	IL16	interleukin 16	638	0.74
chr22_37812190_37812341	0.28	RP1-63G5.5		11215	0.14
chr5_169706251_169706453	0.28	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	12021	0.22
chr11_63305751_63305902	0.28	RARRES3	retinoic acid receptor responder (tazarotene induced) 3	42	0.97
chr6_33663289_33663440	0.28	SBP1	SBP1; Uncharacterized protein	110	0.95
chr20_50143060_50143387	0.28	NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	16035	0.26
chr1_12245359_12245510	0.28	ENSG00000263676	.	6336	0.17
chr19_50923202_50923353	0.28	SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	1062	0.3
chr11_6742431_6742729	0.28	GVINP1	GTPase, very large interferon inducible pseudogene 1	531	0.69
chr14_100850226_100850465	0.28	WDR25	WD repeat domain 25	2008	0.19
chr7_142045834_142045985	0.28	PRSS3P3	protease, serine, 3 pseudogene 3	56300	0.13
chr11_74983514_74983728	0.27	ARRB1	arrestin, beta 1	6122	0.14
chr4_1797283_1797487	0.27	FGFR3	fibroblast growth factor receptor 3	1762	0.33
chr20_62104787_62104938	0.27	KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	869	0.46
chr20_37435383_37435534	0.27	PPP1R16B	protein phosphatase 1, regulatory subunit 16B	1091	0.52
chr2_95716411_95716700	0.27	AC103563.9		2366	0.25
chr20_62488359_62488510	0.27	ABHD16B	abhydrolase domain containing 16B	4132	0.09
chr17_1199306_1199457	0.27	TUSC5	tumor suppressor candidate 5	16424	0.17
chr2_99449405_99449556	0.27	ENSG00000238830	.	7719	0.22
chr15_70545445_70545596	0.27	ENSG00000200216	.	59945	0.15
chr11_67177814_67178291	0.27	CARNS1	carnosine synthase 1	5097	0.07
chr3_18684786_18684937	0.27	ENSG00000228956	.	50518	0.19
chr2_238813522_238813924	0.27	ENSG00000263723	.	35176	0.15
chr1_154932014_154932227	0.27	PYGO2	pygopus family PHD finger 2	2104	0.12
chr4_2838265_2838548	0.27	ADD1	adducin 1 (alpha)	7178	0.2
chr11_67201895_67202105	0.27	AP003419.16		870	0.3
chr17_77904427_77904652	0.26	TBC1D16	TBC1 domain family, member 16	20088	0.18
chr13_53277825_53277976	0.26	LECT1	leukocyte cell derived chemotaxin 1	35587	0.16
chr17_72474398_72474597	0.26	CD300A	CD300a molecule	11496	0.14
chr2_74228872_74229028	0.26	TET3	tet methylcytosine dioxygenase 3	890	0.55
chr13_111948297_111948901	0.26	TEX29	testis expressed 29	24416	0.22
chr3_15319690_15320104	0.26	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	2345	0.23
chr11_441488_441639	0.26	ANO9	anoctamin 9	448	0.56
chr22_42592642_42592793	0.26	TCF20	transcription factor 20 (AR1)	13497	0.16
chr1_207095862_207096179	0.26	FAIM3	Fas apoptotic inhibitory molecule 3	521	0.73
chr19_3024526_3024677	0.26	TLE2	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	424	0.77
chr16_88535878_88536112	0.26	ENSG00000263456	.	669	0.68
chr17_43310695_43311082	0.26	FMNL1	formin-like 1	7554	0.1
chr19_4088417_4088592	0.26	MAP2K2	mitogen-activated protein kinase kinase 2	12541	0.11
chr17_73150023_73150174	0.25	HN1	hematological and neurological expressed 1	137	0.91
chr10_82339230_82339422	0.25	SH2D4B	SH2 domain containing 4B	38751	0.17
chr2_106429372_106429523	0.25	NCK2	NCK adaptor protein 2	3568	0.32
chr19_50064241_50064618	0.25	NOSIP	nitric oxide synthase interacting protein	481	0.57
chr9_92063731_92064015	0.25	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	6995	0.26
chr11_128555736_128555887	0.25	RP11-744N12.3		512	0.52
chr9_136351101_136351399	0.25	SLC2A6	solute carrier family 2 (facilitated glucose transporter), member 6	6991	0.12
chr12_12418765_12419238	0.25	LRP6	low density lipoprotein receptor-related protein 6	702	0.68
chr22_44890267_44890418	0.25	LDOC1L	leucine zipper, down-regulated in cancer 1-like	3836	0.34
chr4_54959914_54960069	0.25	GSX2	GS homeobox 2	6207	0.17
chr11_2860656_2860807	0.25	KCNQ1-AS1	KCNQ1 antisense RNA 1	22067	0.13
chr19_4064720_4064871	0.25	ZBTB7A	zinc finger and BTB domain containing 7A	935	0.4
chr12_133100245_133100396	0.25	FBRSL1	fibrosin-like 1	33163	0.16
chr13_99176253_99176430	0.25	STK24	serine/threonine kinase 24	2089	0.37
chr3_13057227_13057378	0.25	IQSEC1	IQ motif and Sec7 domain 1	28766	0.23
chr2_27530014_27530299	0.25	UCN	urocortin	1157	0.27
chr7_75367789_75368030	0.25	HIP1	huntingtin interacting protein 1	350	0.89
chr1_214460978_214461129	0.25	SMYD2	SET and MYND domain containing 2	6477	0.3
chr22_50754075_50754226	0.25	XX-C283C717.1		1090	0.31
chr19_12550187_12550350	0.24	CTD-3105H18.16	Uncharacterized protein	1628	0.22
chrX_46488224_46488448	0.24	CHST7	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7	55117	0.14
chr17_8533635_8533853	0.24	MYH10	myosin, heavy chain 10, non-muscle	291	0.92
chr12_104350569_104350720	0.24	C12orf73	chromosome 12 open reading frame 73	281	0.87
chr17_48988068_48988440	0.24	TOB1	transducer of ERBB2, 1	42915	0.11
chr1_9776061_9776212	0.24	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	1991	0.31
chr21_46741518_46741669	0.24	ENSG00000215447	.	33626	0.13
chr3_13277082_13277233	0.24	IQSEC1	IQ motif and Sec7 domain 1	162540	0.04
chr20_61424831_61424989	0.24	MRGBP	MRG/MORF4L binding protein	2895	0.16
chr1_151793784_151793935	0.24	RORC	RAR-related orphan receptor C	4708	0.09
chr22_27067872_27068143	0.24	CRYBA4	crystallin, beta A4	50079	0.13
chr19_7741444_7741683	0.24	C19orf59	chromosome 19 open reading frame 59	49	0.93
chr7_151078058_151078311	0.24	NUB1	negative regulator of ubiquitin-like proteins 1	12268	0.13
chr13_114875590_114875798	0.24	RASA3-IT1	RASA3 intronic transcript 1 (non-protein coding)	1399	0.48
chr2_242800699_242800986	0.24	PDCD1	programmed cell death 1	218	0.89

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF423

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0048563	post-embryonic organ morphogenesis(GO:0048563)
0.1	0.2	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.1	0.2	GO:0010040	response to iron(II) ion(GO:0010040)
0.1	0.2	GO:0001778	plasma membrane repair(GO:0001778)
0.1	0.1	GO:0072194	kidney smooth muscle tissue development(GO:0072194)
0.1	0.2	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.2	GO:0051446	positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0	0.1	GO:0009191	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.2	GO:1901538	DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0	0.1	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.2	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.2	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.2	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.1	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.2	GO:0032495	response to muramyl dipeptide(GO:0032495)
0.0	0.2	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.3	GO:0001573	ganglioside metabolic process(GO:0001573)
0.0	0.2	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.1	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0002098	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.2	GO:0035058	nonmotile primary cilium assembly(GO:0035058)
0.0	0.2	GO:0002087	regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0	0.1	GO:0048478	replication fork protection(GO:0048478)
0.0	0.3	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.2	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.1	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0014808	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.0	0.2	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089) positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) positive regulation of cell cycle G1/S phase transition(GO:1902808)
0.0	0.2	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.2	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.1	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.2	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.0	0.1	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.3	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.4	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.0	GO:0070266	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.1	GO:0032769	negative regulation of monooxygenase activity(GO:0032769)
0.0	0.8	GO:0050772	positive regulation of axonogenesis(GO:0050772)
0.0	0.1	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.1	GO:0060088	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.1	GO:0009405	pathogenesis(GO:0009405)
0.0	0.2	GO:0006349	regulation of gene expression by genetic imprinting(GO:0006349)
0.0	0.1	GO:0060155	platelet dense granule organization(GO:0060155)
0.0	0.2	GO:0007063	regulation of sister chromatid cohesion(GO:0007063)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0060120	auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0	0.1	GO:0016198	axon choice point recognition(GO:0016198)
0.0	0.1	GO:0050685	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.0	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.0	GO:0061054	dermatome development(GO:0061054)
0.0	0.1	GO:0048664	neuron fate determination(GO:0048664)
0.0	0.2	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.1	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.0	GO:0060206	estrous cycle phase(GO:0060206)
0.0	0.1	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.0	GO:0002724	regulation of T cell cytokine production(GO:0002724)
0.0	0.1	GO:0015816	glycine transport(GO:0015816)
0.0	0.1	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.4	GO:0045576	mast cell activation(GO:0045576)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.0	GO:0045988	negative regulation of striated muscle contraction(GO:0045988)
0.0	0.0	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.2	GO:0010039	response to iron ion(GO:0010039)
0.0	0.1	GO:0006549	isoleucine metabolic process(GO:0006549)
0.0	0.1	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0045006	DNA deamination(GO:0045006)
0.0	0.0	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.0	GO:0032610	interleukin-1 alpha production(GO:0032610) regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.0	GO:0060413	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.0	GO:0046639	negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0	0.0	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.0	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.1	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0	0.1	GO:0001967	suckling behavior(GO:0001967)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.0	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.0	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.0	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.0	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.0	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.0	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.0	GO:0042819	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.0	GO:0051657	maintenance of organelle location(GO:0051657)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.0	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.1	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.0	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.1	GO:0032461	positive regulation of protein oligomerization(GO:0032461)
0.0	0.1	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.0	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.0	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.0	0.1	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.0	0.1	GO:0010626	regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.7	GO:0031294	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.1	GO:0035590	purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0	0.3	GO:0035303	regulation of dephosphorylation(GO:0035303)
0.0	0.1	GO:0032967	positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967) positive regulation of multicellular organismal metabolic process(GO:0044253)
0.0	0.0	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0	0.1	GO:0002070	epithelial cell maturation(GO:0002070)
0.0	0.1	GO:0016556	mRNA modification(GO:0016556)
0.0	0.1	GO:0002209	behavioral defense response(GO:0002209)
0.0	0.1	GO:0043496	regulation of protein homodimerization activity(GO:0043496)
0.0	0.0	GO:0070295	renal water absorption(GO:0070295)
0.0	0.0	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.0	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.0	GO:0007007	inner mitochondrial membrane organization(GO:0007007)
0.0	0.1	GO:0007080	mitotic metaphase plate congression(GO:0007080)
0.0	0.1	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)
0.0	0.0	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.0	GO:0090185	negative regulation of kidney development(GO:0090185)
0.0	0.0	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.1	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.0	GO:0031062	positive regulation of histone methylation(GO:0031062)
0.0	0.0	GO:0008089	anterograde axonal transport(GO:0008089)
0.0	0.0	GO:1903672	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.1	GO:0001961	positive regulation of cytokine-mediated signaling pathway(GO:0001961)
0.0	0.1	GO:0000085	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.2	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.0	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.0	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.0	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.0	GO:0016559	peroxisome fission(GO:0016559)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.0	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0	0.0	GO:0050665	hydrogen peroxide biosynthetic process(GO:0050665)
0.0	0.0	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0007512	adult heart development(GO:0007512)
0.0	0.2	GO:0008299	isoprenoid biosynthetic process(GO:0008299)
0.0	0.1	GO:0045604	regulation of epidermal cell differentiation(GO:0045604)
0.0	0.0	GO:0002448	mast cell mediated immunity(GO:0002448)
0.0	0.1	GO:0032781	positive regulation of ATPase activity(GO:0032781)
0.0	0.1	GO:0042640	anagen(GO:0042640)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.5	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.2	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.1	GO:0031083	BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.2	GO:0034464	BBSome(GO:0034464)
0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.2	GO:0008290	F-actin capping protein complex(GO:0008290)
0.1	GO:0005587	collagen type IV trimer(GO:0005587)
0.1	GO:0033150	cytoskeletal calyx(GO:0033150)
0.1	GO:0031211	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.1	GO:0070820	tertiary granule(GO:0070820)
0.2	GO:0035631	CD40 receptor complex(GO:0035631)
0.2	GO:0005614	interstitial matrix(GO:0005614)
0.1	GO:0033268	node of Ranvier(GO:0033268)
0.1	GO:0071437	invadopodium(GO:0071437)
0.1	GO:0016939	kinesin II complex(GO:0016939)
0.1	GO:0000791	euchromatin(GO:0000791)
0.1	GO:0032009	early phagosome(GO:0032009)
0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	GO:0044462	external encapsulating structure part(GO:0044462)
0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.1	GO:0000346	transcription export complex(GO:0000346)
0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	GO:0031931	TORC1 complex(GO:0031931)
0.0	GO:0000137	Golgi cis cisterna(GO:0000137)
0.1	GO:0030288	outer membrane-bounded periplasmic space(GO:0030288) cell envelope(GO:0030313) periplasmic space(GO:0042597)
0.1	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.1	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.0	GO:0005797	Golgi medial cisterna(GO:0005797)
0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.1	0.3	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.2	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.1	0.2	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.2	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.4	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.1	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0045159	myosin II binding(GO:0045159)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.2	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.3	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.3	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.2	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.1	GO:1990939	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.0	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.0	0.1	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0031432	titin binding(GO:0031432)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.3	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0070513	death domain binding(GO:0070513)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.0	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.0	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.1	GO:0046625	sphingolipid binding(GO:0046625)
0.0	0.0	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.2	GO:0004659	prenyltransferase activity(GO:0004659)
0.0	0.1	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.1	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.2	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.0	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.0	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.0	0.1	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.0	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.1	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.0	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.0	GO:0016997	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0	0.0	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.0	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.0	GO:0004802	transketolase activity(GO:0004802)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.2	GO:0070566	adenylyltransferase activity(GO:0070566)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.1	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.4	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.2	GO:0015459	potassium channel regulator activity(GO:0015459)
0.0	0.0	GO:0046923	ER retention sequence binding(GO:0046923)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.8	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.1	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	SIG CHEMOTAXIS	Genes related to chemotaxis
0.4	PID ARF 3PATHWAY	Arf1 pathway
0.0	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.9	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.4	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.4	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
0.2	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.3	PID EPHB FWD PATHWAY	EPHB forward signaling
0.3	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.7	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.8	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.1	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.0	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.6	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.3	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.4	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.2	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.3	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.6	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	0.2	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.2	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.0	0.2	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0	0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.0	REACTOME CA DEPENDENT EVENTS	Genes involved in Ca-dependent events
0.0	0.0	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.1	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.1	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling
0.0	0.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)