CREMA results: ZNF740

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Transcription factors associated with ZNF740_ZNF219

Gene Symbol	Gene ID	Gene Info
ZNF740 Ensembl NCBI GeneCards UniProt	ENSG00000139651.9	zinc finger protein 740
ZNF219 Ensembl NCBI GeneCards UniProt	ENSG00000165804.11	zinc finger protein 219

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr14_21552997_21553148	ZNF219	8915	0.087630	0.43	2.4e-01	Click!
chr14_21556036_21556544	ZNF219	5697	0.096919	0.52	1.5e-01	Click!
chr14_21557704_21557855	ZNF219	4208	0.106934	0.66	5.4e-02	Click!
chr14_21560976_21561143	ZNF219	928	0.371417	0.68	4.3e-02	Click!
chr14_21567463_21567799	ZNF219	458	0.454825	-0.71	3.1e-02	Click!

Showing 1 to 5 of 5 entries

Activity of the ZNF740_ZNF219 motif across conditions

Conditions sorted by the z-value of the ZNF740_ZNF219 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_11203608_11204588	0.46	CELF2	CUGBP, Elav-like family member 2	2895	0.29
chr5_175916247_175916556	0.36	ENSG00000221373	.	37638	0.09
chr5_75680037_75680677	0.36	IQGAP2	IQ motif containing GTPase activating protein 2	18717	0.25
chr15_31657045_31657355	0.35	KLF13	Kruppel-like factor 13	1157	0.65
chrX_102940963_102941114	0.34	MORF4L2	mortality factor 4 like 2	111	0.93
chr1_27929391_27929542	0.33	AHDC1	AT hook, DNA binding motif, containing 1	636	0.66
chr10_126849591_126849742	0.33	CTBP2	C-terminal binding protein 2	36	0.99
chr2_134884979_134885130	0.32	ENSG00000263813	.	358	0.9
chr17_76122728_76122959	0.31	TMC6	transmembrane channel-like 6	258	0.86
chr11_66046306_66046457	0.31	CNIH2	cornichon family AMPA receptor auxiliary protein 2	711	0.33

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF740_ZNF219

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.3	GO:0050872	white fat cell differentiation(GO:0050872)
0.1	0.2	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.1	0.2	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.1	0.2	GO:0042661	regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.1	0.2	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.2	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.2	GO:0006513	protein monoubiquitination(GO:0006513)
0.0	0.2	GO:0045646	regulation of erythrocyte differentiation(GO:0045646)

Showing 1 to 10 of 132 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.2	GO:0070820	tertiary granule(GO:0070820)
0.0	0.2	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.2	GO:0043209	myelin sheath(GO:0043209)
0.0	0.2	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.2	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)

Showing 1 to 10 of 29 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	GO:0070888	E-box binding(GO:0070888)
0.1	0.3	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.2	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.2	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.2	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.2	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.2	GO:0050699	WW domain binding(GO:0050699)
0.0	0.2	GO:0008417	fucosyltransferase activity(GO:0008417)

Showing 1 to 10 of 77 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.4	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	0.4	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	0.3	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.2	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.2	PID ARF 3PATHWAY	Arf1 pathway
0.0	0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	0.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.4	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.2	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.2	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.1	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.1	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.1	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1

Showing 1 to 10 of 11 entries

Results for ZNF740_ZNF219

Z-value: 0.97

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Transcription factors associated with ZNF740_ZNF219

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the ZNF740_ZNF219 motif across conditions

Conditions sorted by the z-value of the ZNF740_ZNF219 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF740_ZNF219

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: