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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for ZNF8

Z-value: 1.16

Motif logo

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Transcription factors associated with ZNF8

Gene Symbol Gene ID Gene Info
ZNF8
ENSG00000083842.8 zinc finger protein 8
ZNF8
ENSG00000273439.1 zinc finger protein 8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr19_58790510_58790661ZNF82670.591708-0.501.7e-01Click!
chr19_58792796_58792947ZNF825530.1332130.501.8e-01Click!
chr19_58791136_58791498ZNF89990.283145-0.412.7e-01Click!
chr19_58792474_58792625ZNF822310.1456400.363.4e-01Click!
chr19_58790908_58791124ZNF86980.373969-0.314.1e-01Click!

Activity of the ZNF8 motif across conditions

Conditions sorted by the z-value of the ZNF8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr6_24867689_24867840 0.43 FAM65B
 family with sequence similarity 65, member B
 9777
 0.19
chr2_62441057_62441221 0.42 B3GNT2
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
 1514
 0.37
chr12_56554594_56555181 0.41 MYL6
 myosin, light chain 6, alkali, smooth muscle and non-muscle
 2707
 0.09
chr3_49003922_49004166 0.41 RP13-131K19.1
17255
 0.08
chr22_31673029_31673483 0.40 PIK3IP1
 phosphoinositide-3-kinase interacting protein 1
 15125
 0.1
chr12_65025056_65025207 0.39 RP11-338E21.2
3007
 0.17
chr10_29938536_29938687 0.38 SVIL
 supervillin
 14710
 0.21
chr19_57078181_57078506 0.38 AC007228.11
437
 0.51
chrX_138287334_138287495 0.38 FGF13
 fibroblast growth factor 13
 246
 0.96
chr13_32399322_32399473 0.36 RXFP2
 relaxin/insulin-like family peptide receptor 2
 85718
 0.1
chr21_46645058_46645209 0.35 ADARB1
 adenosine deaminase, RNA-specific, B1
 53576
 0.1
chr3_50231195_50231703 0.35 GNAT1
 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
 1344
 0.29
chr4_120288345_120288496 0.34 ENSG00000201186
 .
 297
 0.91
chr18_74747142_74747293 0.34 MBP
 myelin basic protein
 17483
 0.25
chr6_35578924_35579366 0.34 ENSG00000212579
 .
 40450
 0.12
chr7_114583964_114584237 0.34 MDFIC
 MyoD family inhibitor domain containing
 10176
 0.32
chr6_135346444_135346595 0.33 HBS1L
 HBS1-like (S. cerevisiae)
 1775
 0.4
chr5_79530041_79530192 0.33 ENSG00000239159
 .
 5292
 0.21
chr5_149865294_149865685 0.32 NDST1
 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
 108
 0.97
chr10_6597209_6597469 0.32 PRKCQ
 protein kinase C, theta
 24862
 0.26
chr4_108992806_108993006 0.32 HADH
 hydroxyacyl-CoA dehydrogenase
 67115
 0.1
chr19_41313321_41313683 0.32 EGLN2
 egl-9 family hypoxia-inducible factor 2
 354
 0.81
chr5_95992051_95992224 0.32 CAST
 calpastatin
 5640
 0.21
chr5_35828451_35828602 0.32 CTD-2113L7.1
1406
 0.44
chr8_91654470_91654621 0.32 TMEM64
 transmembrane protein 64
 3195
 0.27
chr18_2993997_2994477 0.31 LPIN2
 lipin 2
 11366
 0.16
chr13_31099418_31099569 0.31 HMGB1
 high mobility group box 1
 58842
 0.14
chr11_35586145_35586296 0.30 PAMR1
 peptidase domain containing associated with muscle regeneration 1
 34372
 0.18
chr2_46579537_46579731 0.30 EPAS1
 endothelial PAS domain protein 1
 55093
 0.13
chr8_145808353_145808654 0.30 CTD-2517M22.9
921
 0.39
chr14_69252719_69253010 0.30 ZFP36L1
 ZFP36 ring finger protein-like 1
 5096
 0.24
chr3_71265807_71265958 0.30 FOXP1
 forkhead box P1
 18350
 0.27
chr16_10275076_10275838 0.30 GRIN2A
 glutamate receptor, ionotropic, N-methyl D-aspartate 2A
 467
 0.87
chr4_154391718_154392045 0.30 KIAA0922
 KIAA0922
 4380
 0.29
chr10_101089012_101089287 0.30 CNNM1
 cyclin M1
 4
 0.99
chr7_150674322_150674753 0.29 KCNH2
 potassium voltage-gated channel, subfamily H (eag-related), member 2
 477
 0.73
chr6_167364098_167364412 0.29 RP11-514O12.4
5357
 0.16
chr19_1446084_1446235 0.29 APC2
 adenomatosis polyposis coli 2
 141
 0.88
chr3_152101319_152101736 0.28 MBNL1
 muscleblind-like splicing regulator 1
 31320
 0.18
chr3_13429216_13429367 0.28 NUP210
 nucleoporin 210kDa
 32518
 0.2
chr20_48011566_48011717 0.28 KCNB1
 potassium voltage-gated channel, Shab-related subfamily, member 1
 87543
 0.07
chr19_2524704_2524855 0.28 ENSG00000252962
 .
 21640
 0.14
chr15_31506827_31507679 0.28 TRPM1
 transient receptor potential cation channel, subfamily M, member 1
 53777
 0.15
chrX_78406329_78406539 0.28 GPR174
 G protein-coupled receptor 174
 20035
 0.29
chr1_115014648_115014799 0.28 TRIM33
 tripartite motif containing 33
 8675
 0.23
chr9_125570423_125570637 0.28 OR1K1
 olfactory receptor, family 1, subfamily K, member 1
 8160
 0.13
chr16_2077290_2077691 0.28 SLC9A3R2
 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
 561
 0.45
chr7_114655426_114655724 0.28 MDFIC
 MyoD family inhibitor domain containing
 81651
 0.11
chr18_21268730_21268881 0.27 LAMA3
 laminin, alpha 3
 602
 0.78
chr10_48477172_48477323 0.27 GDF10
 growth differentiation factor 10
 38271
 0.15
chr21_15924197_15924348 0.27 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
 5608
 0.26
chr16_58550127_58550607 0.27 SETD6
 SET domain containing 6
 950
 0.45
chr11_1870887_1871464 0.26 LSP1
 lymphocyte-specific protein 1
 3025
 0.13
chr21_32530607_32530758 0.26 TIAM1
 T-cell lymphoma invasion and metastasis 1
 28143
 0.24
chr6_45409314_45409465 0.26 RUNX2
 runt-related transcription factor 2
 19167
 0.21
chr2_225746186_225746337 0.26 DOCK10
 dedicator of cytokinesis 10
 64892
 0.15
chr3_134517935_134518086 0.26 EPHB1
 EPH receptor B1
 3027
 0.27
chr6_131424888_131425039 0.26 AKAP7
 A kinase (PRKA) anchor protein 7
 31843
 0.21
chr21_35463147_35463298 0.26 SLC5A3
 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
 17352
 0.2
chr2_204591311_204591600 0.26 CD28
 CD28 molecule
 20039
 0.2
chr19_35670959_35671110 0.26 FXYD5
 FXYD domain containing ion transport regulator 5
 16096
 0.1
chr19_45999731_46000044 0.25 RTN2
 reticulon 2
 426
 0.53
chr16_12172780_12173025 0.25 RP11-276H1.3
11257
 0.16
chr15_78358944_78359095 0.25 TBC1D2B
 TBC1 domain family, member 2B
 554
 0.68
chr7_24324800_24324951 0.25 NPY
 neuropeptide Y
 149
 0.96
chr6_90788187_90788431 0.25 ENSG00000222078
 .
 77084
 0.1
chr5_66452974_66453257 0.25 MAST4
 microtubule associated serine/threonine kinase family member 4
 14853
 0.25
chr5_66816055_66816206 0.25 ENSG00000222939
 .
 55694
 0.18
chr11_119203900_119204051 0.24 RNF26
 ring finger protein 26
 1262
 0.25
chr10_15183836_15183987 0.24 NMT2
 N-myristoyltransferase 2
 18213
 0.17
chr2_191728321_191728478 0.24 GLS
 glutaminase
 17154
 0.2
chr5_110581390_110581541 0.24 CAMK4
 calcium/calmodulin-dependent protein kinase IV
 21681
 0.19
chr14_90148740_90149294 0.24 ENSG00000200312
 .
 29838
 0.14
chr15_77575302_77575453 0.24 PEAK1
 pseudopodium-enriched atypical kinase 1
 27483
 0.24
chr2_30457620_30458309 0.24 LBH
 limb bud and heart development
 2918
 0.32
chr4_7786856_7787007 0.24 AFAP1-AS1
 AFAP1 antisense RNA 1
 31114
 0.19
chrX_72783471_72783622 0.24 CHIC1
 cysteine-rich hydrophobic domain 1
 502
 0.88
chr19_10515778_10516368 0.24 ENSG00000221566
 .
 1859
 0.18
chr1_227949174_227949396 0.24 SNAP47
 synaptosomal-associated protein, 47kDa
 13521
 0.16
chr7_139313866_139314147 0.24 CLEC2L
 C-type lectin domain family 2, member L
 105178
 0.06
chr6_167524624_167524999 0.24 CCR6
 chemokine (C-C motif) receptor 6
 484
 0.81
chr5_38368443_38368594 0.24 EGFLAM-AS3
 EGFLAM antisense RNA 3
 21865
 0.16
chr18_60868113_60868539 0.23 ENSG00000238988
 .
 6428
 0.25
chr13_74607328_74607479 0.23 KLF12
 Kruppel-like factor 12
 38217
 0.23
chr5_141468134_141468285 0.23 NDFIP1
 Nedd4 family interacting protein 1
 19861
 0.2
chr1_204495375_204495526 0.23 MDM4
 Mdm4 p53 binding protein homolog (mouse)
 803
 0.62
chr10_14102538_14102689 0.23 RP11-397C18.2
13670
 0.23
chr5_59783822_59783973 0.23 PDE4D
 phosphodiesterase 4D, cAMP-specific
 6
 0.99
chr10_8443695_8443872 0.23 ENSG00000212505
 .
 255011
 0.02
chr17_63175926_63176077 0.23 RGS9
 regulator of G-protein signaling 9
 42409
 0.18
chr15_68368372_68368523 0.23 PIAS1
 protein inhibitor of activated STAT, 1
 21533
 0.24
chr2_149281301_149281506 0.23 MBD5
 methyl-CpG binding domain protein 5
 55109
 0.16
chr10_6079510_6080013 0.23 IL2RA
 interleukin 2 receptor, alpha
 11797
 0.14
chr6_83552052_83552203 0.23 RP11-445L13__B.3
90193
 0.1
chr7_105901515_105901666 0.23 NAMPT
 nicotinamide phosphoribosyltransferase
 23777
 0.19
chr3_106055125_106055276 0.23 ENSG00000200610
 .
 179544
 0.03
chr17_1935214_1935393 0.23 DPH1
 diphthamide biosynthesis 1
 1384
 0.22
chr9_135224510_135224806 0.23 SETX
 senataxin
 5714
 0.24
chr17_35030341_35030615 0.23 MRM1
 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
 72087
 0.08
chr3_197808077_197808536 0.23 ANKRD18DP
 ankyrin repeat domain 18D, pseudogene
 923
 0.53
chr15_60874078_60874257 0.22 RORA
 RAR-related orphan receptor A
 10573
 0.22
chr5_141508964_141509115 0.22 NDFIP1
 Nedd4 family interacting protein 1
 20969
 0.22
chr1_207503628_207503779 0.22 CD55
 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
 8567
 0.27
chr12_92949909_92950139 0.22 ENSG00000238865
 .
 11261
 0.26
chr10_17275718_17275927 0.22 RP11-124N14.3
1010
 0.46
chr12_121845210_121845376 0.22 RNF34
 ring finger protein 34, E3 ubiquitin protein ligase
 1965
 0.35
chr9_115868029_115868319 0.22 SLC31A2
 solute carrier family 31 (copper transporter), member 2
 45048
 0.14
chr7_130577577_130577746 0.22 ENSG00000226380
 .
 15363
 0.25
chr3_113937014_113937168 0.22 RP11-553L6.2
3853
 0.21
chr1_6505054_6505292 0.22 RP1-202O8.2
1893
 0.19
chr5_32145798_32145949 0.22 ENSG00000200065
 .
 11029
 0.18
chr8_144753183_144753334 0.22 ZNF707
 zinc finger protein 707
 13364
 0.07
chr9_130318408_130318749 0.22 FAM129B
 family with sequence similarity 129, member B
 12789
 0.17
chr1_98257638_98257789 0.22 DPYD-AS2
 DPYD antisense RNA 2
 4764
 0.35
chr1_249116365_249116887 0.22 ENSG00000264500
 .
 3950
 0.17
chr16_67719327_67719733 0.21 C16orf86
 chromosome 16 open reading frame 86
 18737
 0.09
chr15_38978663_38978814 0.21 C15orf53
 chromosome 15 open reading frame 53
 10061
 0.29
chr9_33141497_33141999 0.21 B4GALT1
 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
 13551
 0.15
chr2_38970049_38970200 0.21 SRSF7
 serine/arginine-rich splicing factor 7
 6582
 0.18
chr19_37998405_37998589 0.21 ZNF793
 zinc finger protein 793
 377
 0.57
chr17_45815718_45815869 0.21 TBX21
 T-box 21
 5183
 0.16
chr17_7607725_7607908 0.21 EFNB3
 ephrin-B3
 704
 0.47
chr3_141027177_141027447 0.21 ZBTB38
 zinc finger and BTB domain containing 38
 15743
 0.21
chr5_56413254_56413405 0.21 ENSG00000207293
 .
 51707
 0.14
chr3_15331279_15331629 0.21 SH3BP5
 SH3-domain binding protein 5 (BTK-associated)
 13902
 0.14
chr11_126163833_126164034 0.21 RP11-712L6.7
216
 0.87
chr14_50453460_50453715 0.21 C14orf182
 chromosome 14 open reading frame 182
 20651
 0.16
chr10_33599602_33599753 0.21 ENSG00000244356
 .
 22148
 0.21
chr10_33315822_33316332 0.21 ENSG00000265319
 .
 7775
 0.23
chr3_37292881_37293032 0.21 RP11-259K5.2
7288
 0.17
chr15_39048258_39048409 0.21 C15orf53
 chromosome 15 open reading frame 53
 59534
 0.15
chr11_66081208_66081956 0.21 RP11-867G23.13
1258
 0.19
chr22_31335936_31336207 0.21 MORC2
 MORC family CW-type zinc finger 2
 7190
 0.16
chr14_56739527_56739678 0.21 PELI2
 pellino E3 ubiquitin protein ligase family member 2
 153775
 0.04
chr9_123686052_123686203 0.20 TRAF1
 TNF receptor-associated factor 1
 4920
 0.24
chr13_95836985_95837151 0.20 ENSG00000238463
 .
 25530
 0.23
chr17_43317813_43317964 0.20 FMNL1
 formin-like 1
 554
 0.43
chr8_97602268_97602419 0.20 SDC2
 syndecan 2
 3728
 0.33
chr20_57236648_57237104 0.20 STX16
 syntaxin 16
 5700
 0.18
chr1_24806575_24806726 0.20 RCAN3
 RCAN family member 3
 22737
 0.15
chr19_14523781_14523932 0.20 DDX39A
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
 138
 0.93
chr22_20919945_20920204 0.20 MED15
 mediator complex subunit 15
 14497
 0.14
chr7_107126814_107127106 0.20 GPR22
 G protein-coupled receptor 22
 16455
 0.2
chr7_150263781_150263961 0.20 GIMAP4
 GTPase, IMAP family member 4
 494
 0.81
chr19_45264347_45264498 0.20 ENSG00000253027
 .
 3785
 0.13
chr19_4969744_4969895 0.20 KDM4B
 lysine (K)-specific demethylase 4B
 676
 0.68
chr3_53137929_53138080 0.20 RFT1
 RFT1 homolog (S. cerevisiae)
 26423
 0.15
chr7_130752755_130752906 0.19 ENSG00000199627
 .
 13079
 0.2
chr12_62665115_62665307 0.19 USP15
 ubiquitin specific peptidase 15
 7198
 0.22
chr7_127743675_127744013 0.19 ENSG00000207588
 .
 21931
 0.21
chr1_100877624_100878071 0.19 ENSG00000216067
 .
 33516
 0.16
chr4_173697455_173697606 0.19 ENSG00000241652
 .
 365264
 0.01
chr7_42882815_42882966 0.19 C7orf25
 chromosome 7 open reading frame 25
 68619
 0.11
chr3_13467417_13467568 0.19 NUP210
 nucleoporin 210kDa
 5683
 0.25
chr17_29398999_29399150 0.19 RP11-271K11.5
21030
 0.11
chr9_92077290_92077553 0.19 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 6553
 0.25
chr4_110620562_110620713 0.19 CASP6
 caspase 6, apoptosis-related cysteine peptidase
 3368
 0.22
chr17_41098730_41098881 0.19 ENSG00000212149
 .
 6086
 0.08
chr2_113409796_113409947 0.19 SLC20A1
 solute carrier family 20 (phosphate transporter), member 1
 4592
 0.23
chr3_16955552_16955703 0.19 PLCL2
 phospholipase C-like 2
 18955
 0.22
chr10_33444834_33444985 0.19 NRP1
 neuropilin 1
 29674
 0.18
chr3_30688418_30688599 0.19 TGFBR2
 transforming growth factor, beta receptor II (70/80kDa)
 40415
 0.19
chr2_39443017_39443168 0.19 CDKL4
 cyclin-dependent kinase-like 4
 13581
 0.2
chr2_61691635_61691786 0.19 USP34
 ubiquitin specific peptidase 34
 6194
 0.19
chr15_50722930_50723081 0.19 USP8
 ubiquitin specific peptidase 8
 3914
 0.2
chr4_109348290_109348441 0.19 ENSG00000266046
 .
 149931
 0.04
chr9_89885412_89885563 0.19 ENSG00000212421
 .
 10122
 0.3
chr16_67226498_67226740 0.19 E2F4
 E2F transcription factor 4, p107/p130-binding
 547
 0.48
chr10_104169426_104169807 0.19 PSD
 pleckstrin and Sec7 domain containing
 9285
 0.1
chr16_87695421_87695572 0.19 AC010536.1
 Uncharacterized protein; cDNA FLJ45526 fis, clone BRTHA2027227
 34257
 0.13
chr16_29713724_29714191 0.19 QPRT
 quinolinate phosphoribosyltransferase
 23454
 0.09
chr8_127287160_127287311 0.19 ENSG00000221706
 .
 133232
 0.05
chr12_50138993_50139144 0.18 TMBIM6
 transmembrane BAX inhibitor motif containing 6
 1868
 0.31
chr2_235321270_235321441 0.18 ARL4C
 ADP-ribosylation factor-like 4C
 83889
 0.11
chr7_16968826_16969134 0.18 AGR3
 anterior gradient 3
 47369
 0.17
chr17_45899312_45899856 0.18 OSBPL7
 oxysterol binding protein-like 7
 384
 0.77
chr13_51523103_51523254 0.18 RNASEH2B-AS1
 RNASEH2B antisense RNA 1
 38330
 0.15
chrX_48583462_48583613 0.18 ENSG00000206723
 .
 571
 0.62
chr8_57069675_57070078 0.18 ENSG00000221093
 .
 35965
 0.12
chr19_17597784_17597935 0.18 SLC27A1
 solute carrier family 27 (fatty acid transporter), member 1
 13316
 0.08
chr3_38691341_38691875 0.18 SCN5A
 sodium channel, voltage-gated, type V, alpha subunit
 444
 0.88
chr2_106702316_106702467 0.18 C2orf40
 chromosome 2 open reading frame 40
 20135
 0.23
chrX_48584106_48584257 0.18 ENSG00000206723
 .
 1215
 0.32
chr14_51708170_51708339 0.18 TMX1
 thioredoxin-related transmembrane protein 1
 1368
 0.39
chr11_128499546_128499697 0.18 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 42168
 0.14
chr11_62489486_62489689 0.18 HNRNPUL2
 heterogeneous nuclear ribonucleoprotein U-like 2
 5234
 0.07
chr5_98114835_98114986 0.18 RGMB
 repulsive guidance molecule family member b
 5571
 0.24
chr9_92151633_92152777 0.18 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 39160
 0.16
chr7_156746508_156746659 0.18 NOM1
 nucleolar protein with MIF4G domain 1
 4166
 0.22
chr4_95133944_95134095 0.18 SMARCAD1
 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
 4821
 0.35
chr17_37922924_37923075 0.18 IKZF3
 IKAROS family zinc finger 3 (Aiolos)
 11479
 0.12
chr2_102439045_102439294 0.18 MAP4K4
 mitogen-activated protein kinase kinase kinase kinase 4
 17121
 0.26
chrX_23684782_23684975 0.18 PRDX4
 peroxiredoxin 4
 685
 0.75
chr4_147576742_147576893 0.18 ENSG00000264323
 .
 16404
 0.21
chr1_219348883_219349034 0.18 RP11-135J2.4
1655
 0.37
chr19_39835822_39835973 0.18 SAMD4B
 sterile alpha motif domain containing 4B
 2789
 0.12
chr11_118276298_118276449 0.18 RP11-770J1.5
 Uncharacterized protein
 3763
 0.12
chr16_67338311_67338462 0.18 KCTD19
 potassium channel tetramerization domain containing 19
 10660
 0.09
chr21_34920280_34920507 0.18 SON
 SON DNA binding protein
 4161
 0.15
chr12_777327_777560 0.18 NINJ2
 ninjurin 2
 4498
 0.21

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0071294 cellular response to zinc ion(GO:0071294)
0.1 0.3 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.1 0.2 GO:0032100 positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0 0.1 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.1 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.1 GO:0002890 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.1 GO:0002517 T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.0 0.0 GO:0046398 UDP-glucuronate metabolic process(GO:0046398)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0044415 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0060057 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0050917 sensory perception of umami taste(GO:0050917)
0.0 0.2 GO:0002423 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.1 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.1 GO:0034776 response to histamine(GO:0034776)
0.0 0.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.1 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.1 GO:1903312 negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:1901797 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.0 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.0 GO:0032527 protein exit from endoplasmic reticulum(GO:0032527)
0.0 0.1 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.1 GO:0031297 replication fork processing(GO:0031297)
0.0 0.1 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0043368 positive T cell selection(GO:0043368)
0.0 0.1 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.1 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0 0.0 GO:0070601 centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0 0.1 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0090312 regulation of protein deacetylation(GO:0090311) positive regulation of protein deacetylation(GO:0090312)
0.0 0.1 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.1 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.0 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.0 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.1 GO:0042167 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.0 GO:0034393 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.1 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.0 GO:2000178 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.1 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.0 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.0 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.0 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.0 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.0 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.0 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.1 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.1 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.2 GO:0045730 respiratory burst(GO:0045730)
0.0 0.0 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.0 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.0 0.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.0 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.0 0.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.0 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.0 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0 0.1 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 0.0 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.0 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.0 GO:0060856 establishment of blood-brain barrier(GO:0060856)
0.0 0.2 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.1 GO:0016553 base conversion or substitution editing(GO:0016553)
0.0 0.0 GO:0032966 negative regulation of collagen biosynthetic process(GO:0032966)
0.0 0.0 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.0 GO:0007097 nuclear migration(GO:0007097)
0.0 0.1 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.0 GO:0048289 isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0 0.0 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.0 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.1 GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein(GO:0042517)
0.0 0.1 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.0 0.0 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.0 GO:0090232 positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.0 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.0 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.0 0.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.0 GO:0051176 positive regulation of sulfur metabolic process(GO:0051176)
0.0 0.0 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0021591 ventricular system development(GO:0021591)
0.0 0.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.0 GO:1904035 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0 0.0 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.0 GO:1901419 regulation of response to alcohol(GO:1901419)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0016600 flotillin complex(GO:0016600)
0.0 0.3 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.0 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.4 GO:0005626 obsolete insoluble fraction(GO:0005626)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.1 GO:0043209 myelin sheath(GO:0043209)
0.0 0.1 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.0 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0042555 MCM complex(GO:0042555)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.2 GO:0030332 cyclin binding(GO:0030332)
0.0 0.2 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.0 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.0 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.1 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.0 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.0 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.0 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.0 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.0 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0061630 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.0 0.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.0 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.3 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.0 GO:0008061 chitin binding(GO:0008061)
0.0 0.1 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0 0.0 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.0 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.0 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.0 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.0 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.5 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.1 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.0 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.0 PID CXCR3 PATHWAY CXCR3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.0 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.0 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.0 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.1 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.1 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.3 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.1 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex