Project

ENCODE: H3K4me1 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZNF8

Z-value: 1.16

Motif logo

Transcription factors associated with ZNF8

Gene Symbol	Gene ID	Gene Info
ZNF8 Ensembl NCBI GeneCards UniProt	ENSG00000083842.8	ZNF8
ZNF8 Ensembl NCBI GeneCards UniProt	ENSG00000273439.1	ZNF8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZNF8	chr19_58790510_58790661	267	0.591708	-0.50	1.7e-01	Click!
ZNF8	chr19_58792796_58792947	2553	0.133213	0.50	1.8e-01	Click!
ZNF8	chr19_58791136_58791498	999	0.283145	-0.41	2.7e-01	Click!
ZNF8	chr19_58792474_58792625	2231	0.145640	0.36	3.4e-01	Click!
ZNF8	chr19_58790908_58791124	698	0.373969	-0.31	4.1e-01	Click!

Activity of the ZNF8 motif across conditions

Conditions sorted by the z-value of the ZNF8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_24867689_24867840	0.43	FAM65B	family with sequence similarity 65, member B	9777	0.19
chr2_62441057_62441221	0.42	B3GNT2	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	1514	0.37
chr12_56554594_56555181	0.41	MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	2707	0.09
chr3_49003922_49004166	0.41	RP13-131K19.1		17255	0.08
chr22_31673029_31673483	0.40	PIK3IP1	phosphoinositide-3-kinase interacting protein 1	15125	0.1
chr12_65025056_65025207	0.39	RP11-338E21.2		3007	0.17
chr10_29938536_29938687	0.38	SVIL	supervillin	14710	0.21
chr19_57078181_57078506	0.38	AC007228.11		437	0.51
chrX_138287334_138287495	0.38	FGF13	fibroblast growth factor 13	246	0.96
chr13_32399322_32399473	0.36	RXFP2	relaxin/insulin-like family peptide receptor 2	85718	0.1
chr21_46645058_46645209	0.35	ADARB1	adenosine deaminase, RNA-specific, B1	53576	0.1
chr3_50231195_50231703	0.35	GNAT1	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1	1344	0.29
chr4_120288345_120288496	0.34	ENSG00000201186	.	297	0.91
chr18_74747142_74747293	0.34	MBP	myelin basic protein	17483	0.25
chr6_35578924_35579366	0.34	ENSG00000212579	.	40450	0.12
chr7_114583964_114584237	0.34	MDFIC	MyoD family inhibitor domain containing	10176	0.32
chr6_135346444_135346595	0.33	HBS1L	HBS1-like (S. cerevisiae)	1775	0.4
chr5_79530041_79530192	0.33	ENSG00000239159	.	5292	0.21
chr5_149865294_149865685	0.32	NDST1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	108	0.97
chr10_6597209_6597469	0.32	PRKCQ	protein kinase C, theta	24862	0.26
chr4_108992806_108993006	0.32	HADH	hydroxyacyl-CoA dehydrogenase	67115	0.1
chr19_41313321_41313683	0.32	EGLN2	egl-9 family hypoxia-inducible factor 2	354	0.81
chr5_95992051_95992224	0.32	CAST	calpastatin	5640	0.21
chr5_35828451_35828602	0.32	CTD-2113L7.1		1406	0.44
chr8_91654470_91654621	0.32	TMEM64	transmembrane protein 64	3195	0.27
chr18_2993997_2994477	0.31	LPIN2	lipin 2	11366	0.16
chr13_31099418_31099569	0.31	HMGB1	high mobility group box 1	58842	0.14
chr11_35586145_35586296	0.30	PAMR1	peptidase domain containing associated with muscle regeneration 1	34372	0.18
chr2_46579537_46579731	0.30	EPAS1	endothelial PAS domain protein 1	55093	0.13
chr8_145808353_145808654	0.30	CTD-2517M22.9		921	0.39
chr14_69252719_69253010	0.30	ZFP36L1	ZFP36 ring finger protein-like 1	5096	0.24
chr3_71265807_71265958	0.30	FOXP1	forkhead box P1	18350	0.27
chr16_10275076_10275838	0.30	GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	467	0.87
chr4_154391718_154392045	0.30	KIAA0922	KIAA0922	4380	0.29
chr10_101089012_101089287	0.30	CNNM1	cyclin M1	4	0.99
chr7_150674322_150674753	0.29	KCNH2	potassium voltage-gated channel, subfamily H (eag-related), member 2	477	0.73
chr6_167364098_167364412	0.29	RP11-514O12.4		5357	0.16
chr19_1446084_1446235	0.29	APC2	adenomatosis polyposis coli 2	141	0.88
chr3_152101319_152101736	0.28	MBNL1	muscleblind-like splicing regulator 1	31320	0.18
chr3_13429216_13429367	0.28	NUP210	nucleoporin 210kDa	32518	0.2
chr20_48011566_48011717	0.28	KCNB1	potassium voltage-gated channel, Shab-related subfamily, member 1	87543	0.07
chr19_2524704_2524855	0.28	ENSG00000252962	.	21640	0.14
chr15_31506827_31507679	0.28	TRPM1	transient receptor potential cation channel, subfamily M, member 1	53777	0.15
chrX_78406329_78406539	0.28	GPR174	G protein-coupled receptor 174	20035	0.29
chr1_115014648_115014799	0.28	TRIM33	tripartite motif containing 33	8675	0.23
chr9_125570423_125570637	0.28	OR1K1	olfactory receptor, family 1, subfamily K, member 1	8160	0.13
chr16_2077290_2077691	0.28	SLC9A3R2	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2	561	0.45
chr7_114655426_114655724	0.28	MDFIC	MyoD family inhibitor domain containing	81651	0.11
chr18_21268730_21268881	0.27	LAMA3	laminin, alpha 3	602	0.78
chr10_48477172_48477323	0.27	GDF10	growth differentiation factor 10	38271	0.15
chr21_15924197_15924348	0.27	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	5608	0.26
chr16_58550127_58550607	0.27	SETD6	SET domain containing 6	950	0.45
chr11_1870887_1871464	0.26	LSP1	lymphocyte-specific protein 1	3025	0.13
chr21_32530607_32530758	0.26	TIAM1	T-cell lymphoma invasion and metastasis 1	28143	0.24
chr6_45409314_45409465	0.26	RUNX2	runt-related transcription factor 2	19167	0.21
chr2_225746186_225746337	0.26	DOCK10	dedicator of cytokinesis 10	64892	0.15
chr3_134517935_134518086	0.26	EPHB1	EPH receptor B1	3027	0.27
chr6_131424888_131425039	0.26	AKAP7	A kinase (PRKA) anchor protein 7	31843	0.21
chr21_35463147_35463298	0.26	SLC5A3	solute carrier family 5 (sodium/myo-inositol cotransporter), member 3	17352	0.2
chr2_204591311_204591600	0.26	CD28	CD28 molecule	20039	0.2
chr19_35670959_35671110	0.26	FXYD5	FXYD domain containing ion transport regulator 5	16096	0.1
chr19_45999731_46000044	0.25	RTN2	reticulon 2	426	0.53
chr16_12172780_12173025	0.25	RP11-276H1.3		11257	0.16
chr15_78358944_78359095	0.25	TBC1D2B	TBC1 domain family, member 2B	554	0.68
chr7_24324800_24324951	0.25	NPY	neuropeptide Y	149	0.96
chr6_90788187_90788431	0.25	ENSG00000222078	.	77084	0.1
chr5_66452974_66453257	0.25	MAST4	microtubule associated serine/threonine kinase family member 4	14853	0.25
chr5_66816055_66816206	0.25	ENSG00000222939	.	55694	0.18
chr11_119203900_119204051	0.24	RNF26	ring finger protein 26	1262	0.25
chr10_15183836_15183987	0.24	NMT2	N-myristoyltransferase 2	18213	0.17
chr2_191728321_191728478	0.24	GLS	glutaminase	17154	0.2
chr5_110581390_110581541	0.24	CAMK4	calcium/calmodulin-dependent protein kinase IV	21681	0.19
chr14_90148740_90149294	0.24	ENSG00000200312	.	29838	0.14
chr15_77575302_77575453	0.24	PEAK1	pseudopodium-enriched atypical kinase 1	27483	0.24
chr2_30457620_30458309	0.24	LBH	limb bud and heart development	2918	0.32
chr4_7786856_7787007	0.24	AFAP1-AS1	AFAP1 antisense RNA 1	31114	0.19
chrX_72783471_72783622	0.24	CHIC1	cysteine-rich hydrophobic domain 1	502	0.88
chr19_10515778_10516368	0.24	ENSG00000221566	.	1859	0.18
chr1_227949174_227949396	0.24	SNAP47	synaptosomal-associated protein, 47kDa	13521	0.16
chr7_139313866_139314147	0.24	CLEC2L	C-type lectin domain family 2, member L	105178	0.06
chr6_167524624_167524999	0.24	CCR6	chemokine (C-C motif) receptor 6	484	0.81
chr5_38368443_38368594	0.24	EGFLAM-AS3	EGFLAM antisense RNA 3	21865	0.16
chr18_60868113_60868539	0.23	ENSG00000238988	.	6428	0.25
chr13_74607328_74607479	0.23	KLF12	Kruppel-like factor 12	38217	0.23
chr5_141468134_141468285	0.23	NDFIP1	Nedd4 family interacting protein 1	19861	0.2
chr1_204495375_204495526	0.23	MDM4	Mdm4 p53 binding protein homolog (mouse)	803	0.62
chr10_14102538_14102689	0.23	RP11-397C18.2		13670	0.23
chr5_59783822_59783973	0.23	PDE4D	phosphodiesterase 4D, cAMP-specific	6	0.99
chr10_8443695_8443872	0.23	ENSG00000212505	.	255011	0.02
chr17_63175926_63176077	0.23	RGS9	regulator of G-protein signaling 9	42409	0.18
chr15_68368372_68368523	0.23	PIAS1	protein inhibitor of activated STAT, 1	21533	0.24
chr2_149281301_149281506	0.23	MBD5	methyl-CpG binding domain protein 5	55109	0.16
chr10_6079510_6080013	0.23	IL2RA	interleukin 2 receptor, alpha	11797	0.14
chr6_83552052_83552203	0.23	RP11-445L13__B.3		90193	0.1
chr7_105901515_105901666	0.23	NAMPT	nicotinamide phosphoribosyltransferase	23777	0.19
chr3_106055125_106055276	0.23	ENSG00000200610	.	179544	0.03
chr17_1935214_1935393	0.23	DPH1	diphthamide biosynthesis 1	1384	0.22
chr9_135224510_135224806	0.23	SETX	senataxin	5714	0.24
chr17_35030341_35030615	0.23	MRM1	mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)	72087	0.08
chr3_197808077_197808536	0.23	ANKRD18DP	ankyrin repeat domain 18D, pseudogene	923	0.53
chr15_60874078_60874257	0.22	RORA	RAR-related orphan receptor A	10573	0.22
chr5_141508964_141509115	0.22	NDFIP1	Nedd4 family interacting protein 1	20969	0.22
chr1_207503628_207503779	0.22	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	8567	0.27
chr12_92949909_92950139	0.22	ENSG00000238865	.	11261	0.26
chr10_17275718_17275927	0.22	RP11-124N14.3		1010	0.46
chr12_121845210_121845376	0.22	RNF34	ring finger protein 34, E3 ubiquitin protein ligase	1965	0.35
chr9_115868029_115868319	0.22	SLC31A2	solute carrier family 31 (copper transporter), member 2	45048	0.14
chr7_130577577_130577746	0.22	ENSG00000226380	.	15363	0.25
chr3_113937014_113937168	0.22	RP11-553L6.2		3853	0.21
chr1_6505054_6505292	0.22	RP1-202O8.2		1893	0.19
chr5_32145798_32145949	0.22	ENSG00000200065	.	11029	0.18
chr8_144753183_144753334	0.22	ZNF707	zinc finger protein 707	13364	0.07
chr9_130318408_130318749	0.22	FAM129B	family with sequence similarity 129, member B	12789	0.17
chr1_98257638_98257789	0.22	DPYD-AS2	DPYD antisense RNA 2	4764	0.35
chr1_249116365_249116887	0.22	ENSG00000264500	.	3950	0.17
chr16_67719327_67719733	0.21	C16orf86	chromosome 16 open reading frame 86	18737	0.09
chr15_38978663_38978814	0.21	C15orf53	chromosome 15 open reading frame 53	10061	0.29
chr9_33141497_33141999	0.21	B4GALT1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	13551	0.15
chr2_38970049_38970200	0.21	SRSF7	serine/arginine-rich splicing factor 7	6582	0.18
chr19_37998405_37998589	0.21	ZNF793	zinc finger protein 793	377	0.57
chr17_45815718_45815869	0.21	TBX21	T-box 21	5183	0.16
chr17_7607725_7607908	0.21	EFNB3	ephrin-B3	704	0.47
chr3_141027177_141027447	0.21	ZBTB38	zinc finger and BTB domain containing 38	15743	0.21
chr5_56413254_56413405	0.21	ENSG00000207293	.	51707	0.14
chr3_15331279_15331629	0.21	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	13902	0.14
chr11_126163833_126164034	0.21	RP11-712L6.7		216	0.87
chr14_50453460_50453715	0.21	C14orf182	chromosome 14 open reading frame 182	20651	0.16
chr10_33599602_33599753	0.21	ENSG00000244356	.	22148	0.21
chr10_33315822_33316332	0.21	ENSG00000265319	.	7775	0.23
chr3_37292881_37293032	0.21	RP11-259K5.2		7288	0.17
chr15_39048258_39048409	0.21	C15orf53	chromosome 15 open reading frame 53	59534	0.15
chr11_66081208_66081956	0.21	RP11-867G23.13		1258	0.19
chr22_31335936_31336207	0.21	MORC2	MORC family CW-type zinc finger 2	7190	0.16
chr14_56739527_56739678	0.21	PELI2	pellino E3 ubiquitin protein ligase family member 2	153775	0.04
chr9_123686052_123686203	0.20	TRAF1	TNF receptor-associated factor 1	4920	0.24
chr13_95836985_95837151	0.20	ENSG00000238463	.	25530	0.23
chr17_43317813_43317964	0.20	FMNL1	formin-like 1	554	0.43
chr8_97602268_97602419	0.20	SDC2	syndecan 2	3728	0.33
chr20_57236648_57237104	0.20	STX16	syntaxin 16	5700	0.18
chr1_24806575_24806726	0.20	RCAN3	RCAN family member 3	22737	0.15
chr19_14523781_14523932	0.20	DDX39A	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A	138	0.93
chr22_20919945_20920204	0.20	MED15	mediator complex subunit 15	14497	0.14
chr7_107126814_107127106	0.20	GPR22	G protein-coupled receptor 22	16455	0.2
chr7_150263781_150263961	0.20	GIMAP4	GTPase, IMAP family member 4	494	0.81
chr19_45264347_45264498	0.20	ENSG00000253027	.	3785	0.13
chr19_4969744_4969895	0.20	KDM4B	lysine (K)-specific demethylase 4B	676	0.68
chr3_53137929_53138080	0.20	RFT1	RFT1 homolog (S. cerevisiae)	26423	0.15
chr7_130752755_130752906	0.19	ENSG00000199627	.	13079	0.2
chr12_62665115_62665307	0.19	USP15	ubiquitin specific peptidase 15	7198	0.22
chr7_127743675_127744013	0.19	ENSG00000207588	.	21931	0.21
chr1_100877624_100878071	0.19	ENSG00000216067	.	33516	0.16
chr4_173697455_173697606	0.19	ENSG00000241652	.	365264	0.01
chr7_42882815_42882966	0.19	C7orf25	chromosome 7 open reading frame 25	68619	0.11
chr3_13467417_13467568	0.19	NUP210	nucleoporin 210kDa	5683	0.25
chr17_29398999_29399150	0.19	RP11-271K11.5		21030	0.11
chr9_92077290_92077553	0.19	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	6553	0.25
chr4_110620562_110620713	0.19	CASP6	caspase 6, apoptosis-related cysteine peptidase	3368	0.22
chr17_41098730_41098881	0.19	ENSG00000212149	.	6086	0.08
chr2_113409796_113409947	0.19	SLC20A1	solute carrier family 20 (phosphate transporter), member 1	4592	0.23
chr3_16955552_16955703	0.19	PLCL2	phospholipase C-like 2	18955	0.22
chr10_33444834_33444985	0.19	NRP1	neuropilin 1	29674	0.18
chr3_30688418_30688599	0.19	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	40415	0.19
chr2_39443017_39443168	0.19	CDKL4	cyclin-dependent kinase-like 4	13581	0.2
chr2_61691635_61691786	0.19	USP34	ubiquitin specific peptidase 34	6194	0.19
chr15_50722930_50723081	0.19	USP8	ubiquitin specific peptidase 8	3914	0.2
chr4_109348290_109348441	0.19	ENSG00000266046	.	149931	0.04
chr9_89885412_89885563	0.19	ENSG00000212421	.	10122	0.3
chr16_67226498_67226740	0.19	E2F4	E2F transcription factor 4, p107/p130-binding	547	0.48
chr10_104169426_104169807	0.19	PSD	pleckstrin and Sec7 domain containing	9285	0.1
chr16_87695421_87695572	0.19	AC010536.1	Uncharacterized protein; cDNA FLJ45526 fis, clone BRTHA2027227	34257	0.13
chr16_29713724_29714191	0.19	QPRT	quinolinate phosphoribosyltransferase	23454	0.09
chr8_127287160_127287311	0.19	ENSG00000221706	.	133232	0.05
chr12_50138993_50139144	0.18	TMBIM6	transmembrane BAX inhibitor motif containing 6	1868	0.31
chr2_235321270_235321441	0.18	ARL4C	ADP-ribosylation factor-like 4C	83889	0.11
chr7_16968826_16969134	0.18	AGR3	anterior gradient 3	47369	0.17
chr17_45899312_45899856	0.18	OSBPL7	oxysterol binding protein-like 7	384	0.77
chr13_51523103_51523254	0.18	RNASEH2B-AS1	RNASEH2B antisense RNA 1	38330	0.15
chrX_48583462_48583613	0.18	ENSG00000206723	.	571	0.62
chr8_57069675_57070078	0.18	ENSG00000221093	.	35965	0.12
chr19_17597784_17597935	0.18	SLC27A1	solute carrier family 27 (fatty acid transporter), member 1	13316	0.08
chr3_38691341_38691875	0.18	SCN5A	sodium channel, voltage-gated, type V, alpha subunit	444	0.88
chr2_106702316_106702467	0.18	C2orf40	chromosome 2 open reading frame 40	20135	0.23
chrX_48584106_48584257	0.18	ENSG00000206723	.	1215	0.32
chr14_51708170_51708339	0.18	TMX1	thioredoxin-related transmembrane protein 1	1368	0.39
chr11_128499546_128499697	0.18	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	42168	0.14
chr11_62489486_62489689	0.18	HNRNPUL2	heterogeneous nuclear ribonucleoprotein U-like 2	5234	0.07
chr5_98114835_98114986	0.18	RGMB	repulsive guidance molecule family member b	5571	0.24
chr9_92151633_92152777	0.18	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	39160	0.16
chr7_156746508_156746659	0.18	NOM1	nucleolar protein with MIF4G domain 1	4166	0.22
chr4_95133944_95134095	0.18	SMARCAD1	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	4821	0.35
chr17_37922924_37923075	0.18	IKZF3	IKAROS family zinc finger 3 (Aiolos)	11479	0.12
chr2_102439045_102439294	0.18	MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	17121	0.26
chrX_23684782_23684975	0.18	PRDX4	peroxiredoxin 4	685	0.75
chr4_147576742_147576893	0.18	ENSG00000264323	.	16404	0.21
chr1_219348883_219349034	0.18	RP11-135J2.4		1655	0.37
chr19_39835822_39835973	0.18	SAMD4B	sterile alpha motif domain containing 4B	2789	0.12
chr11_118276298_118276449	0.18	RP11-770J1.5	Uncharacterized protein	3763	0.12
chr16_67338311_67338462	0.18	KCTD19	potassium channel tetramerization domain containing 19	10660	0.09
chr21_34920280_34920507	0.18	SON	SON DNA binding protein	4161	0.15
chr12_777327_777560	0.18	NINJ2	ninjurin 2	4498	0.21

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF8

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0071294	cellular response to zinc ion(GO:0071294)
0.1	0.3	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.1	0.2	GO:0032100	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.1	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.1	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.0	0.1	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0002517	T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.0	0.0	GO:0046398	UDP-glucuronate metabolic process(GO:0046398)
0.0	0.2	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0044415	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0060057	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.2	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0050917	sensory perception of umami taste(GO:0050917)
0.0	0.2	GO:0002423	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.1	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.1	GO:0034776	response to histamine(GO:0034776)
0.0	0.1	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.1	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.1	GO:1903312	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.0	GO:0051097	negative regulation of helicase activity(GO:0051097)
0.0	0.0	GO:0032527	protein exit from endoplasmic reticulum(GO:0032527)
0.0	0.1	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.1	GO:0031297	replication fork processing(GO:0031297)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.1	GO:0032528	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.1	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.0	GO:0070601	centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0	0.1	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0090312	regulation of protein deacetylation(GO:0090311) positive regulation of protein deacetylation(GO:0090312)
0.0	0.1	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.1	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.0	GO:0060605	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.0	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0042167	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.0	GO:0034393	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.1	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.0	GO:2000178	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.1	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.0	0.0	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.0	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0	0.0	GO:0072600	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.1	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.2	GO:0045730	respiratory burst(GO:0045730)
0.0	0.0	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.0	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.0	0.1	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.0	GO:0021819	layer formation in cerebral cortex(GO:0021819)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.0	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0	0.1	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.0	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.0	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.0	GO:0060856	establishment of blood-brain barrier(GO:0060856)
0.0	0.2	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.1	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.1	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.0	GO:0032966	negative regulation of collagen biosynthetic process(GO:0032966)
0.0	0.0	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.0	GO:0007097	nuclear migration(GO:0007097)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.0	GO:0048289	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.0	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein(GO:0042517)
0.0	0.1	GO:0060644	mammary gland epithelial cell differentiation(GO:0060644)
0.0	0.0	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.0	GO:0090232	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.0	GO:0000098	sulfur amino acid catabolic process(GO:0000098)
0.0	0.0	GO:0046668	regulation of retinal cell programmed cell death(GO:0046668)
0.0	0.0	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0	0.0	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0021591	ventricular system development(GO:0021591)
0.0	0.0	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.0	0.0	GO:1904035	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.0	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0	0.0	GO:1901419	regulation of response to alcohol(GO:1901419)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0016600	flotillin complex(GO:0016600)
0.0	0.3	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.1	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.2	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.0	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.4	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.1	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.1	GO:0043209	myelin sheath(GO:0043209)
0.0	0.1	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.0	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.1	GO:0042555	MCM complex(GO:0042555)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.2	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.1	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.2	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.1	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.3	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.3	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.3	GO:0008198	ferrous iron binding(GO:0008198)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.2	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.0	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.0	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.0	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.2	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.0	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0061630	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0015166	polyol transmembrane transporter activity(GO:0015166)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.3	GO:0030295	protein kinase activator activity(GO:0030295)
0.0	0.0	GO:0008061	chitin binding(GO:0008061)
0.0	0.1	GO:0000828	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.0	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.0	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.0	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.0	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.0	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.0	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0030898	actin-dependent ATPase activity(GO:0030898)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.6	PID REELIN PATHWAY	Reelin signaling pathway
0.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.5	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	PID CXCR3 PATHWAY	CXCR3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.2	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.2	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.1	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.3	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex