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ENCODE: ATAC-seq of different tissues during embryonic development

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Results for E2f8

Z-value: 0.73

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Transcription factors associated with E2f8

Gene Symbol	Gene ID	Gene Info
E2f8 Ensembl NCBI MGI UniProt	ENSMUSG00000046179.11	E2F transcription factor 8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr7_48882387_48882677	E2f8	936	0.381853	0.78	3.7e-12	Click!
chr7_48879698_48879867	E2f8	1222	0.313240	0.68	1.0e-08	Click!
chr7_48880593_48880868	E2f8	274	0.704743	0.66	5.0e-08	Click!
chr7_48882737_48882888	E2f8	1216	0.313490	0.49	1.6e-04	Click!
chr7_48875128_48875279	E2f8	48	0.961423	-0.02	8.8e-01	Click!

Activity of the E2f8 motif across conditions

Conditions sorted by the z-value of the E2f8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_48545202_48545700	5.86	Sorcs3	sortilin-related VPS10 domain containing receptor 3	115491	0.07
chr9_100643446_100643943	5.86	Stag1	stromal antigen 1	58	0.97
chr15_55089779_55091008	5.32	Dscc1	DNA replication and sister chromatid cohesion 1	87	0.96
chr9_115165935_115166094	5.10	Gm4665	predicted gene 4665	20044	0.15
chr3_123432402_123432553	4.98	Prss12	protease, serine 12 neurotrypsin (motopsin)	14436	0.13
chr5_150673477_150673662	4.34	Pds5b	PDS5 cohesin associated factor B	170	0.92
chr12_24708357_24708959	3.93	Rrm2	ribonucleotide reductase M2	94	0.96
chr9_36725848_36726788	3.79	Chek1	checkpoint kinase 1	56	0.96
chr3_102145742_102145917	3.65	Casq2	calsequestrin 2	1778	0.26
chr12_104404094_104404246	3.64	Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	2559	0.19
chr3_95665078_95665320	3.50	Mcl1	myeloid cell leukemia sequence 1	6342	0.11
chr8_23034325_23034515	3.49	Ank1	ankyrin 1, erythroid	679	0.69
chr2_25195736_25196168	3.13	Tor4a	torsin family 4, member A	807	0.31
chr16_10834942_10835141	2.86	Rmi2	RecQ mediated genome instability 2	18	0.95
chr17_56303166_56303753	2.84	Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	59	0.95
chr4_137795768_137796555	2.77	Alpl	alkaline phosphatase, liver/bone/kidney	69	0.98
chr11_98907626_98907840	2.74	Cdc6	cell division cycle 6	68	0.95
chr6_34780285_34780491	2.71	Agbl3	ATP/GTP binding protein-like 3	44	0.96
chr7_121981252_121981861	2.63	Cog7	component of oligomeric golgi complex 7	138	0.59
chr15_61985341_61985712	2.50	Myc	myelocytomatosis oncogene	38	0.98
chr8_45253145_45253404	2.44	F11	coagulation factor XI	8757	0.18
chr4_72182335_72182783	2.41	Gm11250	predicted gene 11250	13791	0.19
chr13_73475366_73476070	2.35	Lpcat1	lysophosphatidylcholine acyltransferase 1	3967	0.26
chr9_51008308_51009431	2.29	Sik2	salt inducible kinase 2	67	0.97
chr12_24706721_24707100	2.26	Rrm2	ribonucleotide reductase M2	1331	0.35
chr5_137684632_137685345	2.12	Agfg2	ArfGAP with FG repeats 2	262	0.81
chr6_31586330_31586508	2.08	Gm6117	predicted gene 6117	11452	0.17
chr1_86581833_86582394	1.81	Pde6d	phosphodiesterase 6D, cGMP-specific, rod, delta	404	0.62
chr2_75632701_75632852	1.79	Gm13655	predicted gene 13655	606	0.69
chr11_29172269_29172975	1.79	Ppp4r3b	protein phosphatase 4 regulatory subunit 3B	268	0.83
chr17_8272658_8272950	1.68	Mpc1	mitochondrial pyruvate carrier 1	10100	0.13
chr8_109737190_109738048	1.67	Atxn1l	ataxin 1-like	103	0.96
chr8_112010957_112011159	1.67	Kars	lysyl-tRNA synthetase	208	0.64
chr12_54999125_54999276	1.61	Baz1a	bromodomain adjacent to zinc finger domain 1A	98	0.94
chr11_26387078_26387273	1.59	Fancl	Fanconi anemia, complementation group L	27	0.98
chr4_115062632_115062827	1.55	Tal1	T cell acute lymphocytic leukemia 1	3221	0.2
chr2_130663705_130664395	1.49	Ddrgk1	DDRGK domain containing 1	115	0.93
chr17_29398006_29398391	1.47	Fgd2	FYVE, RhoGEF and PH domain containing 2	21697	0.1
chr5_23787844_23788302	1.45	Rint1	RAD50 interactor 1	332	0.77
chr2_155374011_155374162	1.44	Trp53inp2	transformation related protein 53 inducible nuclear protein 2	6973	0.14
chr13_101545392_101545560	1.44	Gm47533	predicted gene, 47533	270	0.89
chr1_13573759_13574139	1.41	Tram1	translocating chain-associating membrane protein 1	5849	0.23
chr11_16817466_16817617	1.41	Egfros	epidermal growth factor receptor, opposite strand	13161	0.21
chr2_92371871_92372314	1.40	Large2	LARGE xylosyl- and glucuronyltransferase 2	125	0.92
chrX_103622717_103623114	1.39	Ftx	Ftx transcript, Xist regulator (non-protein coding)	415	0.7
chrX_105069770_105069963	1.37	5530601H04Rik	RIKEN cDNA 5530601H04 gene	169	0.94
chr12_4233669_4233893	1.31	Cenpo	centromere protein O	157	0.6
chr16_11270757_11270983	1.30	Mir1945	microRNA 1945	16425	0.12
chr11_45805877_45806040	1.20	F630206G17Rik	RIKEN cDNA F630206G17 gene	2129	0.25
chr2_60796909_60797719	1.20	Rbms1	RNA binding motif, single stranded interacting protein 1	16373	0.25
chr14_20388519_20389160	1.16	Dnajc9	DnaJ heat shock protein family (Hsp40) member C9	18	0.95
chr15_82340761_82340945	1.16	Pheta2	PH domain containing endocytic trafficking adaptor 2	5	0.61
chr18_32556691_32557012	1.15	Gypc	glycophorin C	3129	0.27
chr5_52189815_52190375	1.15	Dhx15	DEAH (Asp-Glu-Ala-His) box polypeptide 15	282	0.69
chr1_72288975_72289126	1.14	Tmem169	transmembrane protein 169	4655	0.14
chr13_81643178_81643470	1.14	Adgrv1	adhesion G protein-coupled receptor V1	10170	0.18
chr17_71598263_71598670	1.14	Trmt61b	tRNA methyltransferase 61B	213	0.87
chr5_75450662_75450882	1.09	Gm42800	predicted gene 42800	51400	0.13
chr3_144198270_144199266	1.07	Gm43445	predicted gene 43445	494	0.79
chr6_149310741_149310934	1.07	Resf1	retroelement silencing factor 1	579	0.7
chr15_79690079_79691459	1.05	Gtpbp1	GTP binding protein 1	76	0.92
chr11_88047219_88047407	1.05	Srsf1	serine and arginine-rich splicing factor 1	60	0.91
chr12_53837518_53837703	0.99	1700060O08Rik	RIKEN cDNA 1700060O08 gene	241782	0.02
chr12_110278889_110279209	0.99	Dio3	deiodinase, iodothyronine type III	19	0.91
chr2_103707189_103707351	0.98	Abtb2	ankyrin repeat and BTB (POZ) domain containing 2	7765	0.17
chr13_21783782_21783987	0.96	H3c11	H3 clustered histone 11	514	0.42
chr6_100288289_100288440	0.93	Rybp	RING1 and YY1 binding protein	879	0.58
chr19_38930513_38931703	0.93	Hells	helicase, lymphoid specific	66	0.98
chr15_98092821_98093001	0.91	Senp1	SUMO1/sentrin specific peptidase 1	24	0.7
chr11_54860143_54861186	0.90	Lyrm7	LYR motif containing 7	55	0.96
chr16_16146270_16147094	0.90	Spidr	scaffolding protein involved in DNA repair	122	0.97
chr16_32277357_32277552	0.89	Rnf168	ring finger protein 168	5	0.96
chr17_17393048_17393199	0.88	Lix1	limb and CNS expressed 1	9549	0.14
chr9_108569718_108570862	0.87	Dalrd3	DALR anticodon binding domain containing 3	376	0.53
chr5_137293156_137293696	0.87	Mir8116	microRNA 8116	354	0.64
chr11_102318737_102318932	0.87	Ubtf	upstream binding transcription factor, RNA polymerase I	262	0.85
chr16_18248696_18249076	0.85	Trmt2a	TRM2 tRNA methyltransferase 2A	3	0.64
chr7_123370222_123370701	0.83	Arhgap17	Rho GTPase activating protein 17	546	0.51
chr12_119390165_119390727	0.83	Macc1	metastasis associated in colon cancer 1	71	0.98
chr7_120865910_120866142	0.83	Gm15774	predicted gene 15774	9272	0.13
chr2_128179990_128180452	0.82	Gm14009	predicted gene 14009	9766	0.22
chr11_113785381_113786461	0.80	Sdk2	sidekick cell adhesion molecule 2	24502	0.14
chr11_79992495_79993374	0.78	Suz12	SUZ12 polycomb repressive complex 2 subunit	172	0.95
chr11_120949321_120949700	0.78	Slc16a3	solute carrier family 16 (monocarboxylic acid transporters), member 3	429	0.72
chrX_150594244_150594395	0.78	Pfkfb1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	159	0.94
chrX_73969838_73969995	0.78	Hcfc1	host cell factor C1	3559	0.14
chr9_35116070_35117303	0.78	4930581F22Rik	RIKEN cDNA 4930581F22 gene	42	0.69
chr1_156986305_156986503	0.76	4930439D14Rik	RIKEN cDNA 4930439D14 gene	46566	0.11
chr7_141658277_141658620	0.75	Muc6	mucin 6, gastric	3129	0.19
chr2_84743716_84744451	0.75	Gm19426	predicted gene, 19426	428	0.65
chr16_55893491_55893669	0.75	Nxpe3	neurexophilin and PC-esterase domain family, member 3	1705	0.27
chr6_145124644_145124840	0.75	Lrmp	lymphoid-restricted membrane protein	2961	0.19
chr15_103014087_103015222	0.75	Mir615	microRNA 615	256	0.74
chr14_43278790_43278941	0.74	Gm17153	predicted gene 17153	780	0.43
chr12_12941527_12942979	0.74	Mycn	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	339	0.83
chr6_142780696_142780976	0.72	Cmas	cytidine monophospho-N-acetylneuraminic acid synthetase	10870	0.18
chr15_55557497_55557715	0.72	Mtbp	Mdm2, transformed 3T3 cell double minute p53 binding protein	11	0.65
chr5_118632445_118632596	0.72	Gm43274	predicted gene 43274	11853	0.15
chr11_95307668_95308006	0.71	Kat7	K(lysine) acetyltransferase 7	1676	0.25
chr3_148685155_148685306	0.71	Gm43575	predicted gene 43575	32170	0.22
chr5_17828791_17828960	0.70	Cd36	CD36 molecule	6821	0.31
chr3_121903373_121903524	0.70	Gm42593	predicted gene 42593	40606	0.12
chr17_33523727_33524084	0.69	Adamts10	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10	299	0.88
chr4_108071243_108071567	0.68	Scp2	sterol carrier protein 2, liver	14	0.97
chr11_53519330_53520879	0.68	Septin8	septin 8	177	0.9
chr19_10059900_10060106	0.67	Fads3	fatty acid desaturase 3	3751	0.16
chrX_109013740_109014058	0.64	Hmgn5	high-mobility group nucleosome binding domain 5	495	0.74
chr11_61957517_61957822	0.62	Specc1	sperm antigen with calponin homology and coiled-coil domains 1	854	0.5
chr10_70109912_70110290	0.62	Ccdc6	coiled-coil domain containing 6	12980	0.25
chr6_15720466_15721441	0.62	Mdfic	MyoD family inhibitor domain containing	134	0.98
chr16_17124641_17125577	0.62	2610318N02Rik	RIKEN cDNA 2610318N02 gene	3	0.87
chr3_90695741_90695892	0.61	S100a9	S100 calcium binding protein A9 (calgranulin B)	95	0.94
chr7_28917363_28917885	0.61	Actn4	actinin alpha 4	1597	0.22
chrX_48169964_48170296	0.59	Sash3	SAM and SH3 domain containing 3	23694	0.15
chr5_30915567_30916466	0.59	Emilin1	elastin microfibril interfacer 1	2277	0.13
chr19_40536565_40536862	0.59	Aldh18a1	aldehyde dehydrogenase 18 family, member A1	18028	0.13
chr2_109935905_109936056	0.58	Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	18333	0.17
chr17_46782076_46782523	0.57	Rpl7l1	ribosomal protein L7-like 1	338	0.8
chr1_163358255_163358406	0.57	Gm24940	predicted gene, 24940	43953	0.11
chr5_115155290_115155651	0.55	Mlec	malectin	2709	0.14
chr5_34659775_34659970	0.52	Nop14	NOP14 nucleolar protein	276	0.66
chr4_108064233_108064422	0.52	Scp2	sterol carrier protein 2, liver	7036	0.14
chr16_85130982_85131137	0.52	Gm49226	predicted gene, 49226	17770	0.17
chr10_128536302_128536612	0.52	Esyt1	extended synaptotagmin-like protein 1	10586	0.06
chr15_57912344_57913100	0.50	Tbc1d31	TBC1 domain family, member 31	283	0.91
chr4_135873755_135874279	0.50	Pnrc2	proline-rich nuclear receptor coactivator 2	167	0.91
chr15_64303447_64303610	0.50	Asap1	ArfGAP with SH3 domain, ankyrin repeat and PH domain1	8161	0.19
chr6_6578303_6578493	0.50	Sem1	SEM1, 26S proteasome complex subunit	260	0.94
chrX_12005409_12006002	0.49	Gm14512	predicted gene 14512	21237	0.22
chr12_110870262_110870418	0.48	Cinp	cyclin-dependent kinase 2 interacting protein	7004	0.09
chr12_110219876_110220027	0.48	Gm40576	predicted gene, 40576	16411	0.11
chrX_96095960_96096527	0.48	Msn	moesin	146	0.97
chr17_45733218_45734434	0.48	1600014C23Rik	RIKEN cDNA 1600014C23 gene	18	0.93
chr7_19149283_19149909	0.48	Snrpd2	small nuclear ribonucleoprotein D2	126	0.69
chr18_35751613_35752417	0.47	Sting1	stimulator of interferon response cGAMP interactor 1	11461	0.09
chr8_113667153_113667345	0.47	Gm30052	predicted gene, 30052	9209	0.17
chr2_170662503_170662712	0.46	Gm14264	predicted gene 14264	142	0.97
chr19_46575201_46575567	0.46	Sfxn2	sideroflexin 2	2017	0.22
chr6_116264345_116264698	0.46	Zfand4	zinc finger, AN1-type domain 4	256	0.64
chr6_126939455_126939771	0.46	Rad51ap1	RAD51 associated protein 1	26	0.83
chr13_23554912_23556285	0.46	H1f3	H1.3 linker histone, cluster member	2336	0.07
chr3_98013071_98014300	0.45	Notch2	notch 2	147	0.96
chr17_56039992_56040714	0.45	Chaf1a	chromatin assembly factor 1, subunit A (p150)	86	0.93
chrX_70476781_70477629	0.45	Tmem185a	transmembrane protein 185A	25	0.95
chr14_55824498_55825973	0.45	Nfatc4	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4	198	0.87
chr3_129878743_129879190	0.45	Pla2g12a	phospholipase A2, group XIIA	152	0.94
chr17_34982022_34982459	0.44	Lsm2	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	31	0.82
chr12_103860813_103860964	0.44	Serpina1a	serine (or cysteine) peptidase inhibitor, clade A, member 1A	2663	0.15
chr7_79391983_79392204	0.44	Fanci	Fanconi anemia, complementation group I	164	0.93
chr7_26055182_26055442	0.44	Cyp2b13	cytochrome P450, family 2, subfamily b, polypeptide 13	6185	0.14
chr10_21160919_21161123	0.44	Myb	myeloblastosis oncogene	37	0.97
chr7_27337516_27337823	0.44	Ltbp4	latent transforming growth factor beta binding protein 4	23	0.96
chr9_62341481_62341954	0.43	Anp32a	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	185	0.95
chr5_33652237_33652883	0.43	Slbp	stem-loop binding protein	14	0.87
chr4_86611505_86611988	0.43	Haus6	HAUS augmin-like complex, subunit 6	273	0.88
chr1_71102176_71102584	0.43	Bard1	BRCA1 associated RING domain 1	766	0.73
chr8_111300149_111300519	0.42	Rfwd3	ring finger and WD repeat domain 3	112	0.95
chr10_12964189_12964763	0.42	Stx11	syntaxin 11	178	0.95
chr15_68362505_68362972	0.42	Gm20732	predicted gene 20732	438	0.76
chr7_114275561_114276736	0.42	Psma1	proteasome subunit alpha 1	30	0.98
chr3_116507746_116508585	0.41	Rtca	RNA 3'-terminal phosphate cyclase	32	0.95
chr16_17619247_17619669	0.40	Smpd4	sphingomyelin phosphodiesterase 4	59	0.95
chrX_7840897_7841392	0.40	Otud5	OTU domain containing 5	220	0.85
chr2_34914173_34914413	0.40	Phf19	PHD finger protein 19	267	0.8
chr10_128635554_128635990	0.39	Ikzf4	IKAROS family zinc finger 4	8876	0.07
chr7_92743280_92743472	0.38	Rab30	RAB30, member RAS oncogene family	1709	0.23
chr9_72491893_72492093	0.38	Tex9	testis expressed gene 9	32	0.95
chr2_93460841_93461064	0.38	Cd82	CD82 antigen	960	0.54
chrX_159255140_159255811	0.37	Rps6ka3	ribosomal protein S6 kinase polypeptide 3	307	0.93
chr15_83122033_83122905	0.37	Rrp7a	ribosomal RNA processing 7 homolog A (S. cerevisiae)	282	0.84
chr9_70275267_70275431	0.37	Myo1e	myosin IE	67981	0.1
chr11_26089100_26089281	0.36	5730522E02Rik	RIKEN cDNA 5730522E02 gene	7590	0.31
chr5_135107788_135108074	0.36	Mlxipl	MLX interacting protein-like	1013	0.35
chr4_84523831_84524181	0.35	Bnc2	basonuclin 2	313	0.94
chr6_136906718_136906869	0.35	Erp27	endoplasmic reticulum protein 27	15347	0.11
chr18_35740072_35740223	0.35	Sting1	stimulator of interferon response cGAMP interactor 1	58	0.95
chr11_98149808_98150661	0.34	Fbxl20	F-box and leucine-rich repeat protein 20	169	0.92
chr2_26504034_26504478	0.33	Notch1	notch 1	432	0.73
chr11_114724912_114725111	0.33	Dnaic2	dynein, axonemal, intermediate chain 2	2397	0.24
chr17_25792314_25793132	0.33	Fam173a	family with sequence similarity 173, member A	75	0.88
chr14_66977102_66977253	0.33	Gm24258	predicted gene, 24258	6725	0.14
chr2_132252313_132253101	0.33	Pcna	proliferating cell nuclear antigen	105	0.89
chr10_127677215_127677476	0.33	Nemp1	nuclear envelope integral membrane protein 1	279	0.67
chr10_128015066_128015273	0.33	Prim1	DNA primase, p49 subunit	1	0.94
chr6_113717739_113717890	0.33	Ghrl	ghrelin	122	0.85
chr5_146963438_146963654	0.33	Mtif3	mitochondrial translational initiation factor 3	197	0.94
chr5_122820802_122821141	0.32	Anapc5	anaphase-promoting complex subunit 5	47	0.97
chr1_136174103_136174692	0.32	Kif21b	kinesin family member 21B	5083	0.13
chr2_112262662_112262916	0.32	Nop10	NOP10 ribonucleoprotein	863	0.42
chr3_36612816_36613750	0.32	Bbs7	Bardet-Biedl syndrome 7 (human)	2	0.97
chr17_35236140_35236368	0.31	Atp6v1g2	ATPase, H+ transporting, lysosomal V1 subunit G2	308	0.49
chr7_102065670_102065844	0.31	Xndc1	Xrcc1 N-terminal domain containing 1	1	0.45
chr14_99100247_99100434	0.30	Pibf1	progesterone immunomodulatory binding factor 1	382	0.6
chr10_43310852_43311026	0.30	Gm16546	predicted gene 16546	8421	0.19
chr6_38551798_38552474	0.30	Luc7l2	LUC7-like 2 (S. cerevisiae)	293	0.87
chr4_43000389_43000942	0.29	Vcp	valosin containing protein	158	0.91
chr12_99561310_99561588	0.29	Foxn3	forkhead box N3	2059	0.21
chr19_46502635_46503186	0.29	Trim8	tripartite motif-containing 8	1208	0.41
chr14_70470911_70471105	0.29	Phyhip	phytanoyl-CoA hydroxylase interacting protein	12485	0.09
chr4_3342703_3342923	0.28	Gm11786	predicted gene 11786	15638	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.7	5.1	GO:0034421	post-translational protein acetylation(GO:0034421)
0.8	2.4	GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process(GO:0044337)
0.8	3.9	GO:0046602	regulation of mitotic centrosome separation(GO:0046602)
0.6	4.5	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.5	2.6	GO:0035610	protein side chain deglutamylation(GO:0035610)
0.5	3.7	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.4	1.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.3	1.0	GO:1900095	regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.3	1.7	GO:1902035	positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.3	1.4	GO:1990564	protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.2	0.7	GO:0032377	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.2	4.2	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.2	2.6	GO:0051984	positive regulation of chromosome segregation(GO:0051984)
0.2	0.9	GO:0070535	histone H2A K63-linked ubiquitination(GO:0070535)
0.2	0.6	GO:2001245	regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.2	0.6	GO:0070488	neutrophil aggregation(GO:0070488)
0.2	1.0	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.2	1.0	GO:0071313	cellular response to caffeine(GO:0071313) cellular response to purine-containing compound(GO:0071415)
0.2	0.7	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.2	0.9	GO:0072711	response to hydroxyurea(GO:0072710) cellular response to hydroxyurea(GO:0072711)
0.2	0.5	GO:0072695	negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.2	0.7	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.2	0.6	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.2	1.1	GO:0019336	phenol-containing compound catabolic process(GO:0019336)
0.2	0.5	GO:0071394	cellular response to testosterone stimulus(GO:0071394)
0.2	0.5	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089)
0.2	0.3	GO:0060375	regulation of mast cell differentiation(GO:0060375)
0.2	0.5	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.2	0.8	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.1	0.7	GO:0033133	positive regulation of glucokinase activity(GO:0033133)
0.1	0.4	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.1	0.3	GO:0010918	positive regulation of mitochondrial membrane potential(GO:0010918)
0.1	0.4	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1	0.4	GO:2000297	negative regulation of synapse maturation(GO:2000297)
0.1	0.1	GO:1904430	negative regulation of t-circle formation(GO:1904430)
0.1	0.4	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.1	1.5	GO:2000001	regulation of DNA damage checkpoint(GO:2000001)
0.1	0.3	GO:1902263	apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.1	0.3	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.1	0.3	GO:0006481	C-terminal protein methylation(GO:0006481)
0.1	2.6	GO:0046677	response to antibiotic(GO:0046677)
0.1	0.3	GO:1902990	mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.1	2.4	GO:0006779	porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.1	0.3	GO:0034197	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1	0.3	GO:0032097	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.1	0.4	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1	0.6	GO:0045631	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.1	0.2	GO:0006848	pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1	0.4	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.1	0.3	GO:0080009	mRNA methylation(GO:0080009)
0.1	0.3	GO:0048478	replication fork protection(GO:0048478)
0.1	0.3	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.1	0.4	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.1	0.1	GO:0009757	carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255)
0.1	0.2	GO:0042505	tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525)
0.1	1.5	GO:0034067	protein localization to Golgi apparatus(GO:0034067)
0.1	0.3	GO:0085020	protein K6-linked ubiquitination(GO:0085020)
0.1	0.4	GO:0043320	natural killer cell degranulation(GO:0043320)
0.1	0.2	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.1	0.6	GO:0035873	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1	0.3	GO:0061087	positive regulation of histone H3-K27 methylation(GO:0061087)
0.1	0.6	GO:0035518	histone H2A monoubiquitination(GO:0035518)
0.0	0.1	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.0	0.8	GO:0034508	centromere complex assembly(GO:0034508)
0.0	0.5	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0	0.1	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.5	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.4	GO:0010388	cullin deneddylation(GO:0010388)
0.0	0.3	GO:0032790	ribosome disassembly(GO:0032790)
0.0	1.6	GO:0006513	protein monoubiquitination(GO:0006513)
0.0	0.4	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	1.1	GO:0007602	phototransduction(GO:0007602)
0.0	0.2	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	1.1	GO:0032781	positive regulation of ATPase activity(GO:0032781)
0.0	0.2	GO:0061622	glycolytic process through glucose-1-phosphate(GO:0061622)
0.0	0.6	GO:0050434	positive regulation of viral transcription(GO:0050434)
0.0	0.9	GO:0061014	positive regulation of mRNA catabolic process(GO:0061014)
0.0	0.1	GO:0019042	viral latency(GO:0019042)
0.0	0.3	GO:1900452	regulation of long term synaptic depression(GO:1900452)
0.0	0.1	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.0	0.0	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0	0.0	GO:0035608	protein deglutamylation(GO:0035608)
0.0	0.1	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.4	GO:2000811	negative regulation of anoikis(GO:2000811)
0.0	0.1	GO:0048549	positive regulation of pinocytosis(GO:0048549)
0.0	0.1	GO:0006287	base-excision repair, gap-filling(GO:0006287)
0.0	0.2	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.2	GO:0097237	cellular response to toxic substance(GO:0097237)
0.0	0.4	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0	0.3	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.0	0.0	GO:1901727	positive regulation of histone deacetylase activity(GO:1901727)
0.0	0.1	GO:0033567	DNA replication, Okazaki fragment processing(GO:0033567)
0.0	0.1	GO:0014029	neural crest formation(GO:0014029)
0.0	0.4	GO:0010569	regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0	0.2	GO:0032534	regulation of microvillus assembly(GO:0032534)
0.0	0.4	GO:0002862	negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0	5.6	GO:0007059	chromosome segregation(GO:0007059)
0.0	0.2	GO:2000510	positive regulation of dendritic cell chemotaxis(GO:2000510)
0.0	0.0	GO:0090169	regulation of spindle assembly(GO:0090169) regulation of mitotic spindle assembly(GO:1901673)
0.0	0.0	GO:0006001	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	1.4	GO:0006261	DNA-dependent DNA replication(GO:0006261)
0.0	0.1	GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0	0.3	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.0	0.1	GO:0032211	negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0	0.1	GO:0021873	forebrain neuroblast division(GO:0021873)
0.0	0.3	GO:0043586	tongue development(GO:0043586)
0.0	0.6	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0	0.0	GO:0060374	mast cell differentiation(GO:0060374)
0.0	0.1	GO:0071873	response to norepinephrine(GO:0071873)
0.0	0.8	GO:0006953	acute-phase response(GO:0006953)
0.0	0.1	GO:0071043	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0014807	regulation of somitogenesis(GO:0014807)
0.0	0.2	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	0.1	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0	0.0	GO:1904338	regulation of dopaminergic neuron differentiation(GO:1904338)
0.0	0.0	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.0	GO:1900368	regulation of RNA interference(GO:1900368)
0.0	0.1	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.0	0.1	GO:0018231	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.2	GO:0009226	nucleotide-sugar biosynthetic process(GO:0009226)
0.0	0.0	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0	0.0	GO:0017198	N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0	1.8	GO:0006260	DNA replication(GO:0006260)
0.0	0.1	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.1	GO:0080182	histone H3-K4 trimethylation(GO:0080182)
0.0	0.0	GO:2001170	negative regulation of ATP biosynthetic process(GO:2001170)
0.0	0.0	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.0	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.0	0.1	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.0	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0	0.3	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.0	0.2	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.0	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.0	0.0	GO:1902036	regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0	0.2	GO:0030497	fatty acid elongation(GO:0030497)
0.0	0.0	GO:1990036	calcium ion import into sarcoplasmic reticulum(GO:1990036)
0.0	0.1	GO:0002031	G-protein coupled receptor internalization(GO:0002031)
0.0	0.1	GO:0030643	cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0	0.0	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.1	GO:1902187	negative regulation of viral release from host cell(GO:1902187)
0.0	0.1	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	2.1	GO:0046777	protein autophosphorylation(GO:0046777)
0.0	0.5	GO:0006749	glutathione metabolic process(GO:0006749)
0.0	0.0	GO:0000379	tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0	0.0	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.1	GO:0014028	notochord formation(GO:0014028)
0.0	0.0	GO:1902416	positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0	0.0	GO:0090309	positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0	0.0	GO:0072015	glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0	0.0	GO:1901492	positive regulation of lymphangiogenesis(GO:1901492)
0.0	0.0	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.5	4.6	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.7	5.1	GO:0031390	Ctf18 RFC-like complex(GO:0031390)
0.4	2.4	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.4	1.1	GO:0070939	Dsl1p complex(GO:0070939)
0.3	0.8	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.2	2.7	GO:0065010	extracellular membrane-bounded organelle(GO:0065010)
0.2	0.4	GO:0033186	CAF-1 complex(GO:0033186)
0.2	2.2	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.2	1.1	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2	5.2	GO:0000791	euchromatin(GO:0000791)
0.2	1.5	GO:0031010	ISWI-type complex(GO:0031010)
0.1	0.7	GO:0001739	sex chromatin(GO:0001739)
0.1	0.7	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1	1.6	GO:0017119	Golgi transport complex(GO:0017119)
0.1	1.0	GO:0030314	junctional membrane complex(GO:0030314)
0.1	0.4	GO:0036396	MIS complex(GO:0036396)
0.1	0.5	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.1	0.5	GO:0030870	Mre11 complex(GO:0030870)
0.1	0.4	GO:1990246	uniplex complex(GO:1990246)
0.1	2.6	GO:0051233	spindle midzone(GO:0051233)
0.1	0.7	GO:0001650	fibrillar center(GO:0001650)
0.1	0.4	GO:1990726	Lsm1-7-Pat1 complex(GO:1990726)
0.1	4.7	GO:0005657	replication fork(GO:0005657)
0.1	0.3	GO:0030689	Noc complex(GO:0030689)
0.1	1.5	GO:0035861	site of double-strand break(GO:0035861)
0.1	0.2	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1	0.9	GO:0005721	pericentric heterochromatin(GO:0005721)
0.1	1.1	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.1	0.6	GO:0043083	synaptic cleft(GO:0043083)
0.1	0.3	GO:0034715	pICln-Sm protein complex(GO:0034715)
0.1	0.3	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.1	0.4	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.1	0.3	GO:0070531	BRCA1-A complex(GO:0070531)
0.1	0.1	GO:1990423	RZZ complex(GO:1990423)
0.1	0.6	GO:0001527	microfibril(GO:0001527)
0.1	0.2	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.1	0.5	GO:0051286	cell tip(GO:0051286)
0.1	0.4	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.1	0.2	GO:0002142	stereocilia ankle link complex(GO:0002142)
0.0	0.4	GO:0070652	HAUS complex(GO:0070652)
0.0	1.0	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.3	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.0	GO:0005833	hemoglobin complex(GO:0005833)
0.0	0.3	GO:0036057	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0	0.3	GO:0034464	BBSome(GO:0034464)
0.0	0.2	GO:0071598	neuronal ribonucleoprotein granule(GO:0071598)
0.0	0.3	GO:1904115	axon cytoplasm(GO:1904115)
0.0	0.2	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.1	GO:0032021	NELF complex(GO:0032021)
0.0	0.1	GO:0030893	meiotic cohesin complex(GO:0030893)
0.0	0.3	GO:0016600	flotillin complex(GO:0016600)
0.0	7.7	GO:0000785	chromatin(GO:0000785)
0.0	0.6	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.2	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0	0.3	GO:0071004	U2-type prespliceosome(GO:0071004)
0.0	0.1	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.3	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.0	GO:0033647	host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648)
0.0	0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.4	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.7	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	1.2	GO:0072562	blood microparticle(GO:0072562)
0.0	0.2	GO:0031430	M band(GO:0031430)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.5	4.6	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.9	2.7	GO:0031493	nucleosomal histone binding(GO:0031493)
0.7	3.6	GO:0035184	histone threonine kinase activity(GO:0035184)
0.7	2.7	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.6	5.1	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.3	1.0	GO:0070538	oleic acid binding(GO:0070538)
0.3	0.9	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.3	2.6	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.2	1.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.2	0.6	GO:0070137	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.2	0.6	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.2	0.9	GO:0070095	fructose-6-phosphate binding(GO:0070095)
0.2	1.0	GO:0050733	RS domain binding(GO:0050733)
0.2	0.5	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.1	0.6	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.1	2.6	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.1	0.5	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1	0.4	GO:0071987	WD40-repeat domain binding(GO:0071987)
0.1	0.8	GO:0001164	RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.1	0.4	GO:0051434	BH3 domain binding(GO:0051434)
0.1	0.3	GO:0005146	leukemia inhibitory factor receptor binding(GO:0005146)
0.1	0.4	GO:0070087	chromo shadow domain binding(GO:0070087)
0.1	0.5	GO:0098505	G-rich strand telomeric DNA binding(GO:0098505)
0.1	0.2	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.1	0.3	GO:1904288	BAT3 complex binding(GO:1904288)
0.1	0.7	GO:0070182	DNA polymerase binding(GO:0070182)
0.1	0.4	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.1	0.6	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.1	0.5	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.1	0.2	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1	3.4	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1	0.3	GO:0043338	CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.1	1.0	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.1	1.0	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.1	GO:0036033	mediator complex binding(GO:0036033)
0.0	0.2	GO:0005329	dopamine transmembrane transporter activity(GO:0005329)
0.0	0.4	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.2	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.3	GO:1990446	U1 snRNP binding(GO:1990446)
0.0	0.4	GO:0070008	serine-type exopeptidase activity(GO:0070008)
0.0	0.2	GO:0034452	dynactin binding(GO:0034452)
0.0	0.2	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.2	GO:0008079	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.1	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0	0.6	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	1.0	GO:0004812	aminoacyl-tRNA ligase activity(GO:0004812)
0.0	0.4	GO:0017160	Ral GTPase binding(GO:0017160)
0.0	0.3	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.4	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.4	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.4	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.3	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.0	0.1	GO:0051033	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.4	GO:0001530	lipopolysaccharide binding(GO:0001530)
0.0	0.4	GO:0051059	NF-kappaB binding(GO:0051059)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.2	GO:0016215	acyl-CoA desaturase activity(GO:0016215)
0.0	0.5	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	1.3	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	8.5	GO:0003682	chromatin binding(GO:0003682)
0.0	0.1	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.5	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	0.1	GO:0034560	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.1	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.4	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.4	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0070567	cytidylyltransferase activity(GO:0070567)
0.0	0.4	GO:0004623	phospholipase A2 activity(GO:0004623)
0.0	0.6	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.1	GO:0004525	ribonuclease III activity(GO:0004525) bidentate ribonuclease III activity(GO:0016443) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	1.2	GO:0031072	heat shock protein binding(GO:0031072)
0.0	0.0	GO:0008193	tRNA guanylyltransferase activity(GO:0008193)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	1.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	0.4	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.0	GO:1990190	peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.8	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	0.0	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.0	0.0	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	2.3	GO:0044389	ubiquitin-like protein ligase binding(GO:0044389)
0.0	0.2	GO:0001056	RNA polymerase III activity(GO:0001056)
0.0	0.0	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	1.0	GO:0004222	metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.6	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.2	10.8	PID E2F PATHWAY	E2F transcription factor network
0.1	1.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	2.6	PID BARD1 PATHWAY	BARD1 signaling events
0.0	2.1	PID LKB1 PATHWAY	LKB1 signaling events
0.0	1.2	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.4	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.7	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	0.8	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.8	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	0.5	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.0	0.6	PID RHOA PATHWAY	RhoA signaling pathway
0.0	0.3	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.4	PID FANCONI PATHWAY	Fanconi anemia pathway
0.0	0.1	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	0.1	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.6	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	0.1	PID ATM PATHWAY	ATM pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.4	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.2	1.9	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.2	6.3	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.1	0.7	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	0.4	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1	2.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	1.8	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.1	2.4	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1	0.8	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.1	1.0	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.1	0.9	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.1	1.1	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.1	0.6	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.6	REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	Genes involved in Processive synthesis on the lagging strand
0.0	0.8	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0	0.7	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	1.6	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.0	0.8	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	0.4	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.8	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.2	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.0	0.4	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.4	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.0	0.1	REACTOME INTEGRATION OF ENERGY METABOLISM	Genes involved in Integration of energy metabolism
0.0	0.3	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	0.2	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.0	0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.4	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.1	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.2	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.4	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	0.3	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.0	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0	0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.2	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.2	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.8	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

Results for E2f8

Z-value: 0.73

Motif logo

Transcription factors associated with E2f8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the E2f8 motif across conditions

Conditions sorted by the z-value of the E2f8 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: