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ENCODE: ATAC-seq of different tissues during embryonic development
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Results for Hif1a

Z-value: 0.64

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Transcription factors associated with Hif1a

Gene Symbol Gene ID Gene Info
Hif1a
ENSMUSG00000021109.7 hypoxia inducible factor 1, alpha subunit

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr12_73907701_73907880Hif1a1140.960521-0.658.4e-08Click!
chr12_73907449_73907656Hif1a3520.858120-0.641.7e-07Click!
chr12_73907945_73908301Hif1a2190.925032-0.601.4e-06Click!
chr12_73908374_73908672Hif1a6190.696810-0.448.0e-04Click!
chr12_73905175_73905337Hif1a26480.239489-0.028.8e-01Click!

Activity of the Hif1a motif across conditions

Conditions sorted by the z-value of the Hif1a motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr14_6756349_6757421 1.93 Gm3636
 predicted gene 3636
 14553
 0.14
chr14_4018192_4019443 1.80 Gm5796
 predicted gene 5796
 5124
 0.14
chr14_3332417_3333262 1.71 Gm2956
 predicted gene 2956
 212
 0.91
chr14_4334095_4335404 1.64 2610042L04Rik
 RIKEN cDNA 2610042L04 gene
 14
 0.97
chr14_3412209_3412992 1.61 Gm10409
 predicted gene 10409
 14
 0.96
chr14_4726126_4727100 1.58 Gm3252
 predicted gene 3252
 162
 0.93
chr14_6108337_6108836 1.54 Gm3468
 predicted gene 3468
 79
 0.95
chr14_3809454_3810456 1.52 Gm3002
 predicted gene 3002
 119
 0.95
chr11_102819100_102819714 1.50 Gjc1
 gap junction protein, gamma 1
 197
 0.89
chr14_3571400_3572424 1.45 Gm3005
 predicted gene 3005
 111
 0.96
chr14_7105202_7106057 1.43 Gm3696
 predicted gene 3696
 5008
 0.15
chr1_179667564_179668717 1.42 Sccpdh
 saccharopine dehydrogenase (putative)
 70
 0.98
chr7_4521231_4521527 1.38 Tnni3
 troponin I, cardiac 3
 812
 0.37
chr14_7488010_7488824 1.34 Gm3752
 predicted gene 3752
 4655
 0.16
chr14_4181957_4182899 1.34 Gm2974
 predicted gene 2974
 148
 0.94
chr4_107830355_107830587 1.33 Lrp8os1
 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, opposite strand 1
 373
 0.53
chr18_24714654_24714883 1.29 Fhod3
 formin homology 2 domain containing 3
 5323
 0.18
chr14_7658268_7659211 1.29 Gm10128
 predicted gene 10128
 14767
 0.16
chr14_3651827_3652389 1.26 Gm3020
 predicted gene 3020
 78
 0.96
chr14_19584518_19585206 1.24 Gm2237
 predicted gene 2237
 273
 0.84
chr14_6426499_6427300 1.23 Lamtor3-ps
 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3, pseudogene
 14417
 0.14
chr8_111094195_111095226 1.20 Pdpr
 pyruvate dehydrogenase phosphatase regulatory subunit
 55
 0.95
chr14_4498574_4499972 1.20 Gm3173
 predicted gene 3173
 15485
 0.11
chr4_139637979_139638130 1.17 Mir7020
 microRNA 7020
 5988
 0.15
chr8_15027100_15028701 1.16 Gm37844
 predicted gene, 37844
 522
 0.44
chr9_87015281_87015918 1.13 Ripply2
 ripply transcriptional repressor 2
 37
 0.97
chr14_5501458_5502048 1.12 Gm3488
 predicted gene, 3488
 79
 0.95
chr7_120102194_120103051 1.11 Tmem159
 transmembrane protein 159
 132
 0.86
chr11_47988672_47989535 1.09 Sgcd
 sarcoglycan, delta (dystrophin-associated glycoprotein)
 134
 0.98
chr8_111144981_111146043 1.08 9430091E24Rik
 RIKEN cDNA 9430091E24 gene
 32
 0.97
chr9_64110607_64110889 1.06 Lctl
 lactase-like
 6399
 0.12
chr7_25010372_25010757 1.06 Atp1a3
 ATPase, Na+/K+ transporting, alpha 3 polypeptide
 4606
 0.12
chr14_6287027_6287952 1.06 Gm3411
 predicted gene 3411
 239
 0.89
chr6_148443752_148444889 1.03 Tmtc1
 transmembrane and tetratricopeptide repeat containing 1
 69
 0.98
chr11_60104775_60106860 1.02 Rai1
 retinoic acid induced 1
 640
 0.67
chr8_29219544_29220019 1.00 Unc5d
 unc-5 netrin receptor D
 145
 0.97
chr5_74147781_74147946 0.99 A330058E17Rik
 RIKEN cDNA A330058E17 gene
 28187
 0.11
chr14_5148821_5149378 0.99 Gm3317
 predicted gene 3317
 15436
 0.11
chr2_144010017_144011636 0.97 Rrbp1
 ribosome binding protein 1
 437
 0.82
chr14_7027128_7027881 0.95 Gm10406
 predicted gene 10406
 55
 0.96
chr14_7174332_7174673 0.92 Gm3512
 predicted gene 3512
 31
 0.97
chr5_25498778_25500023 0.90 Kmt2c
 lysine (K)-specific methyltransferase 2C
 617
 0.62
chr1_22533152_22534195 0.87 Rims1
 regulating synaptic membrane exocytosis 1
 21144
 0.28
chr3_135417369_135417520 0.86 Cisd2
 CDGSH iron sulfur domain 2
 5635
 0.12
chrX_136666320_136667042 0.85 Tceal3
 transcription elongation factor A (SII)-like 3
 70
 0.96
chr7_45234372_45235480 0.84 Cd37
 CD37 antigen
 532
 0.49
chr7_143107542_143107900 0.84 Kcnq1
 potassium voltage-gated channel, subfamily Q, member 1
 170
 0.91
chr2_61812475_61812626 0.82 Tbr1
 T-box brain gene 1
 6277
 0.19
chr14_6889264_6890534 0.81 Gm3667
 predicted gene 3667
 63
 0.97
chr14_50061711_50061923 0.81 Gm37194
 predicted gene, 37194
 457
 0.76
chr1_42698067_42698308 0.80 Pou3f3
 POU domain, class 3, transcription factor 3
 2419
 0.19
chr1_42952543_42953742 0.79 Gpr45
 G protein-coupled receptor 45
 3
 0.98
chr14_4855366_4855912 0.79 Gm3264
 predicted gene 3264
 63
 0.96
chr8_69881901_69882713 0.79 Cilp2
 cartilage intermediate layer protein 2
 5380
 0.11
chr9_114383017_114383329 0.79 Crtap
 cartilage associated protein
 4952
 0.16
chr13_18947816_18948472 0.79 Amph
 amphiphysin
 61
 0.97
chr3_110249839_110251122 0.78 C130013H08Rik
 RIKEN cDNA C130013H08 gene
 465
 0.49
chr3_73053654_73054054 0.78 Slitrk3
 SLIT and NTRK-like family, member 3
 3089
 0.24
chr5_37242202_37242734 0.77 Crmp1
 collapsin response mediator protein 1
 266
 0.92
chr2_13010261_13011265 0.76 Gm37811
 predicted gene, 37811
 877
 0.35
chr4_143211895_143213040 0.76 Prdm2
 PR domain containing 2, with ZNF domain
 238
 0.9
chr12_33957808_33958154 0.75 Twist1
 twist basic helix-loop-helix transcription factor 1
 310
 0.91
chr13_116297452_116297610 0.75 Isl1
 ISL1 transcription factor, LIM/homeodomain
 5820
 0.25
chr12_112781968_112782119 0.75 Ahnak2
 AHNAK nucleoprotein 2
 1032
 0.36
chr9_72924923_72926161 0.74 Pygo1
 pygopus 1
 103
 0.93
chr15_95702329_95702480 0.74 Gm8843
 predicted gene 8843
 12789
 0.16
chr13_48966851_48968700 0.74 Fam120a
 family with sequence similarity 120, member A
 242
 0.95
chr10_78747019_78747870 0.73 Gm30400
 predicted gene, 30400
 285
 0.85
chr1_85325328_85325596 0.72 Gm16025
 predicted gene 16025
 1267
 0.31
chr2_22895114_22896094 0.72 Pdss1
 prenyl (solanesyl) diphosphate synthase, subunit 1
 9
 0.63
chrX_110814525_110815208 0.71 Pou3f4
 POU domain, class 3, transcription factor 4
 586
 0.77
chr11_5788301_5789276 0.71 Dbnl
 drebrin-like
 258
 0.86
chr9_8003315_8004975 0.71 Yap1
 yes-associated protein 1
 245
 0.79
chr14_5460033_5460567 0.69 Gm3194
 predicted gene 3194
 4833
 0.14
chr9_100095718_100095869 0.68 4930519F24Rik
 RIKEN cDNA 4930519F24 gene
 72145
 0.1
chr9_90163003_90164118 0.68 Adamts7
 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7
 334
 0.85
chr17_14279299_14279731 0.68 Smoc2
 SPARC related modular calcium binding 2
 9
 0.98
chr14_5812521_5813051 0.67 Gm3383
 predicted gene 3383
 4804
 0.13
chr4_101419063_101420491 0.66 Ak4
 adenylate kinase 4
 44
 0.97
chr8_84742133_84743295 0.66 G430095P16Rik
 RIKEN cDNA G430095P16 gene
 19707
 0.09
chr7_35554990_35556314 0.65 B230322F03Rik
 RIKEN cDNA B230322F03 gene
 285
 0.62
chr11_121259259_121260714 0.65 Foxk2
 forkhead box K2
 4
 0.96
chr5_142367069_142368113 0.65 Foxk1
 forkhead box K1
 33906
 0.18
chr17_43629678_43630114 0.64 Tdrd6
 tudor domain containing 6
 370
 0.84
chr15_88733665_88734619 0.64 Brd1
 bromodomain containing 1
 88
 0.97
chr7_18957517_18958673 0.63 Nanos2
 nanos C2HC-type zinc finger 2
 29305
 0.06
chr15_57745156_57745804 0.63 9330154K18Rik
 RIKEN cDNA 9330154K18 gene
 6814
 0.22
chr17_27555089_27556137 0.63 Hmga1
 high mobility group AT-hook 1
 884
 0.27
chr13_55471184_55472974 0.62 Mir6944
 microRNA 6944
 5697
 0.08
chr10_85102468_85103421 0.61 Tmem263
 transmembrane protein 263
 201
 0.74
chr16_91223532_91223683 0.61 Gm49614
 predicted gene, 49614
 681
 0.54
chr4_136637166_136638197 0.61 Gm37583
 predicted gene, 37583
 1901
 0.22
chr14_5070417_5071423 0.61 Gm8281
 predicted gene, 8281
 120
 0.95
chr3_80800657_80801686 0.60 Gria2
 glutamate receptor, ionotropic, AMPA2 (alpha 2)
 1408
 0.52
chr5_71657445_71657639 0.60 Gabra4
 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
 278
 0.73
chr2_75246191_75246393 0.60 2600014E21Rik
 RIKEN cDNA 2600014E21 gene
 2108
 0.3
chr1_33907825_33908362 0.60 Dst
 dystonin
 132
 0.68
chr18_25504451_25505014 0.58 Celf4
 CUGBP, Elav-like family member 4
 3493
 0.34
chr13_99516425_99517155 0.58 Gm26559
 predicted gene, 26559
 161
 0.62
chr18_34006863_34007553 0.57 Epb41l4a
 erythrocyte membrane protein band 4.1 like 4a
 242
 0.92
chr8_35328966_35329165 0.56 Ppp1r3b
 protein phosphatase 1, regulatory subunit 3B
 46674
 0.11
chr14_65423658_65423809 0.56 Pnoc
 prepronociceptin
 1427
 0.44
chr16_34921371_34921807 0.56 Mylk
 myosin, light polypeptide kinase
 8753
 0.19
chr11_3331774_3332581 0.56 Pik3ip1
 phosphoinositide-3-kinase interacting protein 1
 68
 0.93
chr14_122490496_122491140 0.56 Gm10837
 predicted gene 10837
 232
 0.87
chr2_153258876_153259060 0.56 Pofut1
 protein O-fucosyltransferase 1
 1396
 0.34
chr3_57574902_57575246 0.56 Wwtr1
 WW domain containing transcription regulator 1
 754
 0.61
chr9_107400062_107400379 0.56 Cacna2d2
 calcium channel, voltage-dependent, alpha 2/delta subunit 2
 151
 0.93
chr10_80225959_80227288 0.55 Pwwp3a
 PWWP domain containing 3A, DNA repair factor
 32
 0.94
chr2_152143351_152143985 0.55 Tcf15
 transcription factor 15
 107
 0.96
chr12_117533503_117534508 0.55 Rapgef5
 Rap guanine nucleotide exchange factor (GEF) 5
 117
 0.97
chr1_181352151_181352477 0.54 Cnih3
 cornichon family AMPA receptor auxiliary protein 3
 314
 0.88
chr11_7055619_7056056 0.54 Adcy1
 adenylate cyclase 1
 7652
 0.26
chr3_129204151_129204986 0.54 Pitx2
 paired-like homeodomain transcription factor 2
 621
 0.7
chr7_46179909_46180259 0.53 Abcc8
 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
 51
 0.96
chr11_51855495_51856955 0.53 Jade2
 jade family PHD finger 2
 900
 0.57
chr6_39256581_39257096 0.53 Gm26008
 predicted gene, 26008
 9104
 0.16
chr7_6171760_6172680 0.53 Zfp444
 zinc finger protein 444
 6
 0.95
chrX_157613038_157613189 0.52 Gm15173
 predicted gene 15173
 8
 0.96
chr18_65430370_65431071 0.52 Malt1
 MALT1 paracaspase
 218
 0.9
chr5_136038932_136039111 0.52 Upk3b
 uroplakin 3B
 525
 0.64
chr13_71558486_71558841 0.52 Gm47811
 predicted gene, 47811
 66311
 0.11
chr10_24479227_24479575 0.52 Gm15271
 predicted gene 15271
 31911
 0.15
chr12_45563232_45563656 0.52 Gm48517
 predicted gene, 48517
 9843
 0.27
chr2_152093402_152093892 0.52 Srxn1
 sulfiredoxin 1 homolog (S. cerevisiae)
 11869
 0.13
chr3_101109480_101110654 0.51 Ptgfrn
 prostaglandin F2 receptor negative regulator
 211
 0.94
chr1_59376261_59376435 0.51 Gm29016
 predicted gene 29016
 2582
 0.29
chr9_114528016_114528485 0.51 C130032M10Rik
 RIKEN cDNA C130032M10 gene
 12553
 0.16
chr7_5080037_5080839 0.50 Epn1
 epsin 1
 145
 0.87
chr2_37775771_37775969 0.50 Crb2
 crumbs family member 2
 379
 0.88
chr17_55445138_55445530 0.49 St6gal2
 beta galactoside alpha 2,6 sialyltransferase 2
 48
 0.98
chr12_108794058_108794786 0.49 Yy1
 YY1 transcription factor
 1449
 0.23
chr17_28271837_28272180 0.49 Ppard
 peroxisome proliferator activator receptor delta
 111
 0.94
chr11_82388737_82388922 0.49 Tmem132e
 transmembrane protein 132E
 71
 0.97
chr2_156614281_156614628 0.48 Dlgap4
 DLG associated protein 4
 749
 0.35
chr7_138909400_138910240 0.48 Bnip3
 BCL2/adenovirus E1B interacting protein 3
 301
 0.83
chr6_80622673_80623041 0.48 Gm44231
 predicted gene, 44231
 32172
 0.23
chr6_48629216_48629950 0.48 AI854703
 expressed sequence AI854703
 1648
 0.16
chr12_20415451_20415611 0.47 Gm49929
 predicted gene, 49929
 406
 0.77
chr8_117157446_117158085 0.47 Gan
 giant axonal neuropathy
 370
 0.87
chr2_48538627_48539050 0.47 Gm13481
 predicted gene 13481
 81593
 0.1
chr18_35920048_35920506 0.46 Gm50405
 predicted gene, 50405
 3018
 0.15
chr14_122463926_122464344 0.46 Zic5
 zinc finger protein of the cerebellum 5
 1542
 0.26
chr4_154329867_154330297 0.46 Prdm16
 PR domain containing 16
 4770
 0.18
chr10_80398762_80400128 0.46 Mbd3
 methyl-CpG binding domain protein 3
 23
 0.93
chr13_73265452_73265676 0.46 Irx4
 Iroquois homeobox 4
 5067
 0.17
chr6_72898945_72900607 0.46 Kcmf1
 potassium channel modulatory factor 1
 73
 0.97
chr4_49844763_49845632 0.45 Grin3a
 glutamate receptor ionotropic, NMDA3A
 352
 0.92
chr18_40256699_40257075 0.45 Kctd16
 potassium channel tetramerisation domain containing 16
 75
 0.96
chr4_82513118_82513685 0.45 Gm11266
 predicted gene 11266
 5385
 0.22
chr2_147188117_147188295 0.45 6430503K07Rik
 RIKEN cDNA 6430503K07 gene
 782
 0.52
chr13_94868641_94869006 0.45 Otp
 orthopedia homeobox
 6779
 0.21
chr8_57354026_57354218 0.45 5033428I22Rik
 RIKEN cDNA 5033428I22 gene
 13322
 0.13
chr7_28294529_28294993 0.44 Dll3
 delta like canonical Notch ligand 3
 280
 0.78
chr7_49088814_49088965 0.44 Gm32849
 predicted gene, 32849
 3806
 0.23
chr2_79585158_79585309 0.44 Itprid2
 ITPR interacting domain containing 2
 50119
 0.16
chr12_102729973_102730175 0.43 Gm28373
 predicted gene 28373
 2741
 0.12
chr19_24031055_24031408 0.43 Fam189a2
 family with sequence similarity 189, member A2
 212
 0.93
chr9_80332183_80332515 0.42 Myo6
 myosin VI
 25435
 0.21
chr6_99726441_99726592 0.42 Prok2
 prokineticin 2
 124
 0.9
chr9_107231249_107231435 0.42 Dock3
 dedicator of cyto-kinesis 3
 240
 0.6
chr5_110652819_110653593 0.42 Noc4l
 NOC4 like
 53
 0.74
chr14_69390979_69391250 0.42 Gm21451
 predicted gene, 21451
 260
 0.86
chr18_46109567_46109759 0.42 Gm38337
 predicted gene, 38337
 3596
 0.27
chr14_33319515_33320532 0.41 Arhgap22
 Rho GTPase activating protein 22
 320
 0.89
chr6_119107307_119108229 0.41 Cacna1c
 calcium channel, voltage-dependent, L type, alpha 1C subunit
 207
 0.96
chr4_138395338_138395489 0.41 AB041806
 hypothetical protein, MNCb-2457
 215
 0.85
chr12_18609538_18611003 0.40 Gm48398
 predicted gene, 48398
 114
 0.96
chr13_54765971_54766190 0.40 Sncb
 synuclein, beta
 17
 0.96
chrX_162759829_162760925 0.40 Rbbp7
 retinoblastoma binding protein 7, chromatin remodeling factor
 25
 0.97
chr9_8544024_8544863 0.40 Trpc6
 transient receptor potential cation channel, subfamily C, member 6
 200
 0.96
chr1_177448201_177448585 0.40 Zbtb18
 zinc finger and BTB domain containing 18
 2572
 0.22
chr16_14445264_14445415 0.40 Abcc1
 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
 15669
 0.17
chr5_28460507_28460658 0.40 9530036O11Rik
 RIKEN cDNA 9530036O11Rik
 2308
 0.3
chr13_71963383_71964045 0.40 Irx1
 Iroquois homeobox 1
 9
 0.98
chr17_83954879_83955189 0.39 Gm35229
 predicted gene, 35229
 1214
 0.31
chr9_53705535_53706804 0.39 Rab39
 RAB39, member RAS oncogene family
 63
 0.96
chr13_17993545_17993782 0.39 Yae1d1
 Yae1 domain containing 1
 314
 0.75
chr8_111739568_111739875 0.39 Bcar1
 breast cancer anti-estrogen resistance 1
 4088
 0.22
chr14_69609343_69609518 0.39 Loxl2
 lysyl oxidase-like 2
 48
 0.96
chr10_81392422_81392592 0.38 Smim24
 small integral membrane protein 24
 544
 0.44
chr17_56626470_56627486 0.38 Lonp1
 lon peptidase 1, mitochondrial
 91
 0.92
chr1_64735773_64736678 0.38 Gm38058
 predicted gene, 38058
 15
 0.96
chr8_90907824_90909226 0.38 Chd9
 chromodomain helicase DNA binding protein 9
 89
 0.52
chr7_37769955_37770699 0.38 Zfp536
 zinc finger protein 536
 365
 0.9
chr15_38298982_38300199 0.38 Klf10
 Kruppel-like factor 10
 205
 0.91
chr7_101821788_101822627 0.38 Phox2a
 paired-like homeobox 2a
 1461
 0.21
chr1_120602158_120602362 0.37 En1
 engrailed 1
 158
 0.96
chr6_89361531_89362433 0.37 Plxna1
 plexin A1
 638
 0.7
chr12_55598801_55599099 0.37 Insm2
 insulinoma-associated 2
 477
 0.8
chr7_109703238_109703866 0.37 Denn2b
 DENN domain containing 2B
 53
 0.6
chr9_92541870_92542582 0.37 Plod2
 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
 3
 0.92
chr5_148398815_148400002 0.37 Slc7a1
 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
 383
 0.89
chr5_129724468_129725740 0.36 Nipsnap2
 nipsnap homolog 2
 3
 0.95
chr16_92357164_92357320 0.36 Kcne1
 potassium voltage-gated channel, Isk-related subfamily, member 1
 1632
 0.26
chr11_117864041_117864389 0.36 Tmem235
 transmembrane protein 235
 3463
 0.12
chr17_69417243_69417687 0.36 C030034I22Rik
 RIKEN cDNA C030034I22 gene
 4
 0.97
chr1_90797381_90797532 0.36 Col6a3
 collagen, type VI, alpha 3
 2735
 0.29
chr1_25829654_25830461 0.36 Adgrb3
 adhesion G protein-coupled receptor B3
 350
 0.61
chr8_106893544_106894153 0.35 Utp4
 UTP4 small subunit processome component
 197
 0.4

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of Hif1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.3 1.1 GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis(GO:0003253)
0.2 0.6 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 0.5 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.2 0.5 GO:0033505 floor plate morphogenesis(GO:0033505)
0.2 0.6 GO:0001923 B-1 B cell differentiation(GO:0001923)
0.2 0.2 GO:0072025 distal convoluted tubule development(GO:0072025) DCT cell differentiation(GO:0072069) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) metanephric DCT cell differentiation(GO:0072240)
0.1 0.9 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 0.6 GO:0061743 motor learning(GO:0061743)
0.1 0.3 GO:0021564 vagus nerve development(GO:0021564)
0.1 0.4 GO:0032025 response to cobalt ion(GO:0032025)
0.1 0.2 GO:0033122 negative regulation of purine nucleotide catabolic process(GO:0033122)
0.1 0.3 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1 0.4 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.1 0.8 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.1 0.3 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 1.3 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.1 0.4 GO:0086045 membrane depolarization during AV node cell action potential(GO:0086045)
0.1 1.0 GO:0021859 pyramidal neuron differentiation(GO:0021859)
0.1 0.2 GO:0071655 macrophage colony-stimulating factor production(GO:0036301) granulocyte colony-stimulating factor production(GO:0071611) regulation of granulocyte colony-stimulating factor production(GO:0071655) regulation of macrophage colony-stimulating factor production(GO:1901256)
0.1 0.5 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.1 0.5 GO:0014028 notochord formation(GO:0014028)
0.1 0.3 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.4 GO:2001023 regulation of response to drug(GO:2001023)
0.1 0.3 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.5 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.1 0.2 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.1 0.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 0.2 GO:2000302 positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.1 0.3 GO:0015822 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.1 0.2 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 0.2 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.1 0.2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1 0.3 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 0.3 GO:1903011 negative regulation of bone development(GO:1903011)
0.1 0.4 GO:0003348 cardiac endothelial cell differentiation(GO:0003348)
0.1 0.4 GO:0090383 phagosome acidification(GO:0090383)
0.1 0.7 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.2 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.1 0.3 GO:0019230 proprioception(GO:0019230)
0.1 0.3 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 0.2 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.1 0.2 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.1 0.3 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.2 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.1 0.3 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.2 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 0.2 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1 0.2 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.8 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.2 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.8 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 0.6 GO:0051014 actin filament severing(GO:0051014)
0.1 0.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.1 0.7 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.1 0.2 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.3 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.1 0.2 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.1 0.2 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.2 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.7 GO:0046033 AMP metabolic process(GO:0046033)
0.1 0.4 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 0.5 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.0 0.2 GO:0042297 vocal learning(GO:0042297) imitative learning(GO:0098596) learned vocalization behavior or vocal learning(GO:0098598)
0.0 0.2 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.0 0.1 GO:0060916 mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0 0.1 GO:0035799 ureter maturation(GO:0035799)
0.0 0.5 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.2 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.1 GO:2001016 positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0 0.2 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.4 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.8 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.2 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.1 GO:1901873 regulation of post-translational protein modification(GO:1901873) negative regulation of post-translational protein modification(GO:1901874)
0.0 0.8 GO:0007289 spermatid nucleus differentiation(GO:0007289)
0.0 0.2 GO:0019478 D-amino acid catabolic process(GO:0019478)
0.0 0.2 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 0.0 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.0 0.2 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.2 GO:0003357 noradrenergic neuron differentiation(GO:0003357)
0.0 0.4 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.6 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.2 GO:0061339 establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.0 0.4 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.2 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.7 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.1 GO:0071476 cellular hypotonic response(GO:0071476)
0.0 0.2 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.3 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.5 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.0 1.0 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 0.3 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.0 0.1 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.2 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.1 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.0 0.0 GO:1902302 regulation of potassium ion export(GO:1902302)
0.0 0.1 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.1 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.2 GO:0034651 cortisol biosynthetic process(GO:0034651)
0.0 0.4 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.2 GO:0061042 vascular wound healing(GO:0061042)
0.0 0.1 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.1 GO:0065001 specification of axis polarity(GO:0065001)
0.0 0.2 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.1 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.1 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.2 GO:0060013 righting reflex(GO:0060013)
0.0 0.2 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.4 GO:0071800 podosome assembly(GO:0071800)
0.0 0.1 GO:0035788 cell migration involved in kidney development(GO:0035787) cell migration involved in metanephros development(GO:0035788) metanephric mesenchymal cell migration(GO:0035789) positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) regulation of metanephric mesenchymal cell migration(GO:2000589) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0 0.1 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0 0.2 GO:2000637 positive regulation of gene silencing by miRNA(GO:2000637)
0.0 0.4 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.1 GO:1900045 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.4 GO:0046688 response to copper ion(GO:0046688)
0.0 0.1 GO:0010288 response to lead ion(GO:0010288)
0.0 0.2 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853)
0.0 0.1 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 0.4 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.0 GO:0097694 establishment of RNA localization to telomere(GO:0097694)
0.0 0.4 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.1 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.2 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:1903689 regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.0 0.0 GO:0046098 guanine metabolic process(GO:0046098)
0.0 0.2 GO:0035879 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 0.2 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.1 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0 0.1 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.1 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.1 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 0.2 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.0 0.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.0 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.2 GO:0006415 translational termination(GO:0006415)
0.0 0.0 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.0 0.6 GO:0009268 response to pH(GO:0009268)
0.0 0.1 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.0 0.0 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0 0.4 GO:0042417 dopamine metabolic process(GO:0042417)
0.0 0.2 GO:0060123 regulation of growth hormone secretion(GO:0060123)
0.0 0.1 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.0 0.1 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0021984 adenohypophysis development(GO:0021984)
0.0 0.2 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0 0.0 GO:0043622 cortical microtubule organization(GO:0043622)
0.0 0.6 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.0 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.0 0.0 GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915)
0.0 0.1 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.4 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.1 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.0 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.0 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.1 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.1 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.2 GO:0071475 cellular response to salt stress(GO:0071472) cellular hyperosmotic salinity response(GO:0071475)
0.0 0.1 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.0 0.0 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.0 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.0 GO:0001807 regulation of type IV hypersensitivity(GO:0001807)
0.0 0.1 GO:0043545 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.1 GO:0021546 rhombomere development(GO:0021546)
0.0 0.1 GO:0099515 actin filament-based transport(GO:0099515)
0.0 0.0 GO:0098903 regulation of membrane repolarization during action potential(GO:0098903)
0.0 0.1 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0 0.1 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 0.2 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.0 0.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.0 GO:0044838 cell quiescence(GO:0044838)
0.0 0.1 GO:0014721 voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0 0.0 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.0 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.1 GO:0048012 hepatocyte growth factor receptor signaling pathway(GO:0048012)
0.0 0.0 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0 0.1 GO:0010225 response to UV-C(GO:0010225)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.0 GO:0086011 membrane repolarization during action potential(GO:0086011)
0.0 0.0 GO:0042505 tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525)
0.0 0.2 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.0 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.0 0.1 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.2 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.0 GO:0044845 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506) cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) chain elongation of O-linked mannose residue(GO:0044845) cellular component macromolecule biosynthetic process(GO:0070589)
0.0 0.0 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.1 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.1 GO:0071763 nuclear membrane organization(GO:0071763)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.4 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 0.6 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.4 GO:0044308 axonal spine(GO:0044308)
0.1 0.3 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.3 GO:0030689 Noc complex(GO:0030689)
0.1 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.6 GO:0005861 troponin complex(GO:0005861)
0.1 0.2 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 1.3 GO:0005922 connexon complex(GO:0005922)
0.1 0.9 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 0.5 GO:0097542 ciliary tip(GO:0097542)
0.1 0.4 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.2 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 0.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.6 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.1 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 0.5 GO:0033391 chromatoid body(GO:0033391)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.4 GO:0005921 gap junction(GO:0005921)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.6 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.1 GO:0035363 histone locus body(GO:0035363)
0.0 0.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:1990423 RZZ complex(GO:1990423)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 0.6 GO:0031941 filamentous actin(GO:0031941)
0.0 0.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.6 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 1.5 GO:0043195 terminal bouton(GO:0043195)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.0 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.1 GO:0097651 phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0 0.1 GO:0042567 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0 0.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.1 GO:0097452 GAIT complex(GO:0097452)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0097449 astrocyte projection(GO:0097449)
0.0 0.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.0 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.4 GO:0001772 immunological synapse(GO:0001772)
0.0 0.0 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.0 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 0.0 GO:0070110 ciliary neurotrophic factor receptor complex(GO:0070110)
0.0 0.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:0045180 basal cortex(GO:0045180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.3 1.0 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.2 0.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2 0.5 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.2 0.5 GO:0030172 troponin C binding(GO:0030172)
0.1 0.9 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.5 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1 0.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.4 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 0.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 1.3 GO:0005243 gap junction channel activity(GO:0005243)
0.1 0.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.6 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 0.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 0.4 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 0.2 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.1 0.9 GO:0031005 filamin binding(GO:0031005)
0.1 0.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.3 GO:0015189 arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.1 0.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 0.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 0.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.2 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.1 0.3 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.4 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.2 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.5 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.4 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.1 GO:0004104 cholinesterase activity(GO:0004104)
0.0 1.4 GO:0043738 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.2 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.2 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.3 GO:0043912 D-lysine oxidase activity(GO:0043912)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.2 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.4 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.2 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.9 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.3 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.2 GO:0043338 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 0.1 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0 0.1 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.0 0.3 GO:0005542 folic acid binding(GO:0005542)
0.0 0.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0031014 troponin T binding(GO:0031014)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.1 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.4 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.1 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.0 0.0 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.0 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0 0.1 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0098988 G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.1 GO:0052832 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.0 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.2 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 0.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.1 GO:0042979 ornithine decarboxylase regulator activity(GO:0042979)
0.0 0.2 GO:0035198 miRNA binding(GO:0035198)
0.0 0.0 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.0 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.0 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.1 GO:0102345 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.1 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.0 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.2 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.1 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.0 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.9 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.7 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.4 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.4 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.1 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.6 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.2 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.1 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.1 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 0.3 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 1.0 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 0.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.4 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.5 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.2 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.5 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.1 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.0 0.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.2 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.1 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.0 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.0 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.1 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.1 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.1 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.2 REACTOME AMYLOIDS Genes involved in Amyloids