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ENCODE: ATAC-seq of different tissues during embryonic development

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Results for Isl1

Z-value: 10.05

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Transcription factors associated with Isl1

Gene Symbol	Gene ID	Gene Info
Isl1 Ensembl NCBI MGI UniProt	ENSMUSG00000042258.7	ISL1 transcription factor, LIM/homeodomain

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr13_116305222_116305373	Isl1	1100	0.569857	0.80	4.0e-13	Click!
chr13_116297196_116297347	Isl1	6080	0.248985	0.71	1.5e-09	Click!
chr13_116309234_116309535	Isl1	38	0.981295	0.70	2.8e-09	Click!
chr13_116304768_116305058	Isl1	1484	0.463314	0.69	5.5e-09	Click!
chr13_116293962_116294162	Isl1	9289	0.236979	0.58	2.7e-06	Click!

Activity of the Isl1 motif across conditions

Conditions sorted by the z-value of the Isl1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr14_64595318_64595919	33.85	Mir3078	microRNA 3078	4433	0.18
chr13_39524261_39524439	33.21	Gm47351	predicted gene, 47351	8753	0.2
chr5_149527921_149528686	33.19	Wdr95	WD40 repeat domain 95	376	0.81
chrX_13346707_13347908	29.20	Gm7129	predicted gene 7129	20288	0.14
chr18_81830833_81831208	28.62	Gm30454	predicted gene, 30454	18996	0.19
chr4_65888333_65888871	26.62	Trim32	tripartite motif-containing 32	283353	0.01
chr6_96286333_96286534	25.84	1700123L14Rik	RIKEN cDNA 1700123L14 gene	120190	0.06
chr5_85239463_85240008	25.43	Gm21006	predicted gene, 21006	372890	0.01
chr18_45896851_45897467	25.33	A330093E20Rik	RIKEN cDNA A330093E20 gene	650	0.79
chr2_43978848_43979182	25.13	Arhgap15	Rho GTPase activating protein 15	86026	0.1
chr3_66326110_66326323	25.06	Veph1	ventricular zone expressed PH domain-containing 1	29379	0.18
chr8_61325062_61325301	24.57	1700001D01Rik	RIKEN cDNA 1700001D01 gene	36309	0.13
chr9_15866407_15866579	24.50	Mtnr1b	melatonin receptor 1B	7967	0.23
chr7_109165964_109166186	23.95	Lmo1	LIM domain only 1	4437	0.2
chr11_58400392_58400572	23.95	Gm12252	predicted gene 12252	3967	0.11
chr2_35849935_35850217	23.55	Gm10829	predicted gene 10829	5881	0.2
chr3_40070102_40070729	23.40	Gm42785	predicted gene 42785	246838	0.02
chr2_21060324_21060508	23.09	Gm13376	predicted gene 13376	36683	0.16
chr4_79530917_79531075	22.98	Gm11263	predicted gene 11263	203288	0.03
chr10_92162409_92163019	22.20	Rmst	rhabdomyosarcoma 2 associated transcript (non-coding RNA)	47	0.98
chr8_45508006_45508255	22.07	Sorbs2	sorbin and SH3 domain containing 2	212	0.94
chr13_83749525_83749738	22.05	C130071C03Rik	RIKEN cDNA C130071C03 gene	10768	0.12
chr4_71484616_71485009	21.71	Rps18-ps1	ribosomal protein S18, pseudogene 1	113616	0.07
chr10_16052455_16052829	21.29	C330004P14Rik	RIKEN cDNA C330004P14 gene	260865	0.02
chr1_192755693_192756022	21.19	Gm22265	predicted gene, 22265	10286	0.17
chr8_33747412_33747586	21.05	Smim18	small integral membrane protein 18	271	0.88
chr17_76111639_76112128	20.94	Gm24126	predicted gene, 24126	37337	0.22
chr5_35454198_35454812	20.89	Gm43377	predicted gene 43377	58407	0.08
chr3_45385015_45385410	20.40	Pcdh10	protocadherin 10	2579	0.24
chr1_51650752_51650944	20.31	Gm28055	predicted gene 28055	47052	0.14
chr3_68824497_68825036	20.28	Gm7270	predicted gene 7270	21313	0.12
chr12_44839950_44840386	20.21	Gm15901	predicted gene 15901	83012	0.1
chr10_37378009_37378297	20.19	Gm26535	predicted gene, 26535	40667	0.19
chr12_17048993_17049526	20.11	Gm48538	predicted gene, 48538	16154	0.17
chr17_9543267_9543689	19.80	Gm49807	predicted gene, 49807	6213	0.28
chr7_92258664_92258972	19.72	Dlg2	discs large MAGUK scaffold protein 2	23691	0.23
chr19_26770137_26770516	19.70	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	165	0.96
chr16_89538151_89538450	19.61	Krtap7-1	keratin associated protein 7-1	29977	0.13
chr10_52742737_52743261	19.54	Gm47624	predicted gene, 47624	49161	0.11
chr2_146724257_146724438	19.50	Gm14111	predicted gene 14111	31358	0.22
chr3_127294086_127294512	19.19	Gm42970	predicted gene 42970	5374	0.15
chr13_72028642_72028801	19.15	Irx1	Iroquois homeobox 1	64998	0.13
chr16_25016242_25016817	19.03	A230028O05Rik	RIKEN cDNA A230028O05 gene	43110	0.19
chr2_63963076_63963322	18.76	Fign	fidgetin	134789	0.06
chr13_83661208_83661451	18.70	Mef2c	myocyte enhancer factor 2C	8441	0.18
chr15_50735926_50736259	18.45	Trps1	transcriptional repressor GATA binding 1	91429	0.09
chr8_61515184_61515647	18.43	Palld	palladin, cytoskeletal associated protein	485	0.84
chr6_49021447_49021653	18.31	Gpnmb	glycoprotein (transmembrane) nmb	14996	0.08
chr9_90693284_90693632	18.31	Gm2497	predicted gene 2497	40066	0.15
chr18_57262231_57262735	18.28	Gm50200	predicted gene, 50200	52657	0.11
chr18_40796377_40796528	18.25	Rps19-ps13	ribosomal protein S19, pseudogene 13	70183	0.11
chr11_47264465_47264671	18.23	Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	114954	0.07
chr8_78556826_78557206	18.20	Slc10a7	solute carrier family 10 (sodium/bile acid cotransporter family), member 7	20735	0.18
chr5_9345097_9345292	18.20	Gm15733	predicted gene 15733	8565	0.2
chr15_37135024_37136161	18.11	Gm9509	predicted gene 9509	36812	0.14
chr7_49699439_49699606	18.00	Htatip2	HIV-1 Tat interactive protein 2	59593	0.11
chr7_88261931_88262082	17.91	Ctsc	cathepsin C	16079	0.22
chr16_63278367_63278696	17.77	Gm33912	predicted gene, 33912	61089	0.15
chr11_82579895_82580440	17.76	Gm24612	predicted gene, 24612	16012	0.2
chr17_66869624_66870037	17.75	Gm49940	predicted gene, 49940	7590	0.18
chrX_101987046_101987197	17.73	Nhsl2	NHS-like 2	17923	0.15
chr13_58971668_58972019	17.72	Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	100108	0.06
chr15_36967359_36968246	17.72	Gm34590	predicted gene, 34590	28938	0.13
chr2_10525644_10525960	17.70	Mir669h	microRNA 669h	7647	0.01
chr17_78501306_78501507	17.60	Vit	vitrin	6658	0.17
chr3_102980219_102980386	17.51	Sike1	suppressor of IKBKE 1	15406	0.12
chr4_55929493_55929703	17.43	Gm12519	predicted gene 12519	64141	0.14
chrX_161524009_161524161	17.41	Prkaca-ps1	protein kinase, cAMP dependent, catalytic, alpha pseudogene 1	37600	0.22
chr13_6306939_6307331	17.26	Gm35615	predicted gene, 35615	12421	0.23
chr3_145825482_145825700	17.24	Ddah1	dimethylarginine dimethylaminohydrolase 1	15112	0.2
chr16_39287252_39287499	17.20	Gm36742	predicted gene, 36742	98469	0.08
chr7_131778146_131778326	17.18	Gm44547	predicted gene 44547	8343	0.22
chr13_28295576_28295772	17.14	Gm47172	predicted gene, 47172	10105	0.23
chr9_84253597_84253862	17.10	Gm26146	predicted gene, 26146	65374	0.12
chr8_45507619_45508001	16.90	Sorbs2	sorbin and SH3 domain containing 2	2	0.98
chr16_42339557_42339849	16.89	Gap43	growth associated protein 43	948	0.66
chr6_47228750_47229021	16.73	Cntnap2	contactin associated protein-like 2	15502	0.28
chr2_105674521_105675719	16.64	Pax6	paired box 6	11	0.97
chr18_42704653_42704822	16.51	C030004G16Rik	RIKEN cDNA C030004G16 gene	82278	0.08
chr6_77243554_77244106	16.49	Lrrtm1	leucine rich repeat transmembrane neuronal 1	908	0.69
chr3_104058968_104059448	16.48	Gm42696	predicted gene 42696	1067	0.33
chr2_181766899_181767258	16.43	Myt1	myelin transcription factor 1	36	0.97
chr6_5408845_5409023	16.43	Asb4	ankyrin repeat and SOCS box-containing 4	18507	0.23
chr9_71879542_71879779	16.37	Tcf12	transcription factor 12	5051	0.13
chr12_56458764_56459233	16.33	Sfta3-ps	surfactant associated 3, pseudogene	34326	0.12
chr17_43158272_43158631	16.14	E130008D07Rik	RIKEN cDNA E130008D07 gene	160	0.97
chr4_71485302_71485664	16.10	Rps18-ps1	ribosomal protein S18, pseudogene 1	114287	0.07
chr13_56774410_56774604	16.07	Gm45623	predicted gene 45623	20680	0.21
chr6_8294057_8294761	16.03	Umad1	UMAP1-MVP12 associated (UMA) domain containing 1	23943	0.14
chr18_30197602_30197916	15.91	Gm49980	predicted gene, 49980	69490	0.12
chr13_34129793_34130880	15.86	Tubb2b	tubulin, beta 2B class IIB	18	0.96
chr12_58670274_58670654	15.85	Gm18873	predicted gene, 18873	93442	0.08
chr6_8352593_8352826	15.75	Gm16055	predicted gene 16055	11427	0.18
chr12_77739490_77739672	15.65	4930458K08Rik	RIKEN cDNA 4930458K08 gene	56520	0.12
chr7_73637071_73637452	15.58	Gm44737	predicted gene 44737	6644	0.1
chr3_26835054_26835226	15.53	Gm37659	predicted gene, 37659	177624	0.03
chr6_32373945_32374204	15.51	Plxna4os3	plexin A4, opposite strand 3	70161	0.11
chr2_64706718_64706919	15.47	Gm13576	predicted gene 13576	136178	0.05
chr3_26641406_26641733	15.30	Spata16	spermatogenesis associated 16	3919	0.29
chr14_46077518_46077669	15.30	Ubb-ps	ubiquitin B, pseudogene	6435	0.2
chr15_10421430_10421775	15.29	Dnajc21	DnaJ heat shock protein family (Hsp40) member C21	28390	0.15
chr2_74426718_74427115	15.25	Lnpk	lunapark, ER junction formation factor	106190	0.05
chr4_110209740_110209990	15.22	Elavl4	ELAV like RNA binding protein 4	13283	0.29
chr6_98046634_98046821	15.20	Mitf	melanogenesis associated transcription factor	54806	0.15
chr14_35095601_35095765	15.18	Gm49034	predicted gene, 49034	123755	0.06
chr11_24363754_24364273	15.17	Gm12068	predicted gene 12068	62233	0.12
chr7_19175722_19176163	15.14	Eml2	echinoderm microtubule associated protein like 2	479	0.59
chr10_23016379_23016546	15.01	Gm47787	predicted gene, 47787	59878	0.13
chr3_17616549_17616970	14.94	Gm38154	predicted gene, 38154	53929	0.16
chr6_58837806_58838284	14.94	Herc3	hect domain and RLD 3	4345	0.25
chr15_103519338_103519794	14.88	Pde1b	phosphodiesterase 1B, Ca2+-calmodulin dependent	4152	0.16
chr9_124439329_124439899	14.84	Ppp2r3d	protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta	1254	0.4
chr11_71414747_71415135	14.80	Gm16013	predicted gene 16013	21239	0.21
chr12_5144239_5144620	14.76	Gm9110	predicted gene 9110	76981	0.09
chr13_83984413_83984945	14.72	Gm4241	predicted gene 4241	3312	0.25
chr10_87486341_87486591	14.70	Ascl1	achaete-scute family bHLH transcription factor 1	7194	0.2
chr16_63806861_63807216	14.68	Epha3	Eph receptor A3	56375	0.15
chr19_14777197_14777401	14.64	Gm26026	predicted gene, 26026	58819	0.15
chr5_42068234_42068511	14.59	Gm16223	predicted gene 16223	412	0.91
chr13_76802462_76802613	14.58	Mctp1	multiple C2 domains, transmembrane 1	22670	0.24
chr16_77537354_77537608	14.57	Gm36963	predicted gene, 36963	2401	0.2
chr1_127531215_127531971	14.55	Tmem163	transmembrane protein 163	5837	0.29
chr3_31309752_31310443	14.47	Slc7a14	solute carrier family 7 (cationic amino acid transporter, y+ system), member 14	281	0.81
chr8_31091237_31091775	14.46	Dusp26	dual specificity phosphatase 26 (putative)	144	0.96
chr9_52278418_52278613	14.45	Gm25562	predicted gene, 25562	12684	0.22
chr6_22834243_22834395	14.42	Gm43629	predicted gene 43629	28990	0.15
chr2_130352053_130352242	14.40	Gm14044	predicted gene 14044	33182	0.07
chr2_144127511_144127732	14.38	Gm11687	predicted gene 11687	15752	0.16
chr12_33035669_33036432	14.31	Cdhr3	cadherin-related family member 3	16936	0.14
chr7_62046082_62046717	14.28	Mir344f	microRNA Mir344f	151	0.94
chr10_27468497_27468689	14.28	Gm23353	predicted gene, 23353	16304	0.24
chr2_62047014_62047411	14.22	Slc4a10	solute carrier family 4, sodium bicarbonate cotransporter-like, member 10	567	0.84
chr10_104686774_104686997	14.18	Gm25522	predicted gene, 25522	178423	0.03
chr4_28935550_28935919	14.16	Epha7	Eph receptor A7	63810	0.13
chr9_27298463_27299015	14.13	Igsf9b	immunoglobulin superfamily, member 9B	465	0.82
chr7_112535354_112535706	14.12	Parvaos	parvin, alpha, opposite strand	153	0.96
chr10_39227529_39227710	14.11	Gm31562	predicted gene, 31562	17427	0.16
chr7_51784054_51784235	14.01	Gm29296	predicted gene 29296	11418	0.17
chr13_79430948_79431368	14.01	Gm48470	predicted gene, 48470	10249	0.24
chr5_112481948_112482441	13.98	Sez6l	seizure related 6 homolog like	7067	0.17
chr18_23394845_23395028	13.95	Dtna	dystrobrevin alpha	20199	0.27
chr3_85764601_85764835	13.94	Fam160a1	family with sequence similarity 160, member A1	18452	0.2
chr2_97478952_97479288	13.91	Lrrc4c	leucine rich repeat containing 4C	11031	0.3
chr2_179481364_179481534	13.88	Cdh4	cadherin 4	37216	0.18
chr14_75566269_75566669	13.88	Cby2	chibby family member 2	25480	0.19
chr4_110153152_110153342	13.79	Elavl4	ELAV like RNA binding protein 4	69901	0.13
chr2_146723162_146723336	13.77	Gm14111	predicted gene 14111	32456	0.21
chr1_18191166_18191317	13.75	Defb44-ps	defensin beta 44, pseudogene	32323	0.14
chr11_117454302_117454453	13.75	Gm11732	predicted gene 11732	28199	0.11
chr3_8510380_8510590	13.73	Stmn2	stathmin-like 2	899	0.63
chr5_111220876_111221370	13.72	Ttc28	tetratricopeptide repeat domain 28	4335	0.22
chr3_62454253_62454452	13.71	Dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36	18235	0.22
chr18_74956461_74956661	13.69	Lipg	lipase, endothelial	4701	0.11
chr13_84571624_84571828	13.67	Gm26913	predicted gene, 26913	119215	0.06
chr4_120332877_120333106	13.65	Foxo6os	forkhead box O6, opposite strand	41641	0.15
chr7_61939801_61940302	13.64	Mir344-2	microRNA 344-2	55	0.95
chr4_110287470_110287673	13.63	Elavl4	ELAV like RNA binding protein 4	44	0.99
chr2_109678555_109678726	13.62	Bdnf	brain derived neurotrophic factor	1608	0.32
chr12_46520967_46521283	13.52	Gm7422	predicted gene 7422	41798	0.18
chr9_94410108_94410502	13.48	Gm5370	predicted gene 5370	2179	0.35
chr2_10293635_10293822	13.48	Sfmbt2	Scm-like with four mbt domains 2	76782	0.03
chr12_120015533_120015684	13.47	Gm27236	predicted gene 27236	15081	0.24
chr11_35203810_35203973	13.46	Gm26070	predicted gene, 26070	10510	0.24
chr14_104298418_104298592	13.45	D130079A08Rik	RIKEN cDNA D130079A08 gene	160811	0.04
chr15_8659976_8660428	13.41	Gm37310	predicted gene, 37310	5129	0.23
chr8_86389721_86389961	13.39	Gm24490	predicted gene, 24490	97340	0.07
chr9_10681606_10682000	13.36	Gm7529	predicted gene 7529	52837	0.17
chr1_51216342_51216995	13.36	Gm29325	predicted gene 29325	21447	0.19
chr15_66239660_66240017	13.33	Kcnq3	potassium voltage-gated channel, subfamily Q, member 3	46213	0.14
chr9_37625246_37625717	13.32	Siae	sialic acid acetylesterase	3827	0.14
chr9_105379897_105380048	13.31	Nek11	NIMA (never in mitosis gene a)-related expressed kinase 11	13049	0.16
chrX_110318504_110318684	13.31	Gm7134	predicted gene 7134	54159	0.18
chr8_112268552_112269162	13.30	Gm3635	predicted gene 3635	31891	0.23
chr5_147155070_147155280	13.30	Gsx1	GS homeobox 1	33521	0.11
chr11_16299934_16300272	13.27	Vstm2a	V-set and transmembrane domain containing 2A	36885	0.19
chr6_47239363_47240145	13.18	Cntnap2	contactin associated protein-like 2	4633	0.33
chr6_148615895_148616290	13.18	Gm6313	predicted gene 6313	1783	0.35
chr4_151696178_151696329	13.16	Camta1	calmodulin binding transcription activator 1	165397	0.03
chr10_30327889_30328266	13.15	Gm4780	predicted gene 4780	44841	0.17
chr4_87651182_87651681	13.14	Gm12604	predicted gene 12604	70642	0.13
chr5_103160967_103161542	13.12	Mapk10	mitogen-activated protein kinase 10	44675	0.17
chr4_88211578_88211756	13.11	Gm12645	predicted gene 12645	59971	0.11
chr16_77648330_77648508	13.10	C130023A14Rik	RIKEN cDNA C130023A14 gene	2079	0.17
chr8_67972439_67972650	13.09	Psd3	pleckstrin and Sec7 domain containing 3	2030	0.35
chr16_49193672_49193981	13.07	1700026J12Rik	RIKEN cDNA 1700026J12 gene	61946	0.12
chr11_112869991_112870994	13.06	4933434M16Rik	RIKEN cDNA 4933434M16 gene	45313	0.16
chr15_88360840_88360991	13.04	4930445N06Rik	RIKEN cDNA 4930445N06 gene	45283	0.16
chr10_36534044_36534213	13.02	Hs3st5	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	26721	0.24
chr13_21005724_21006043	13.01	Aoah	acyloxyacyl hydrolase	4750	0.24
chr16_51589915_51590114	12.99	Gm49608	predicted gene, 49608	173066	0.04
chrX_69666420_69666593	12.99	Gm8172	predicted pseudogene 8172	60261	0.15
chr8_74557794_74557991	12.98	Gm11033	predicted gene 11033	276028	0.01
chr10_23449639_23449790	12.97	Eya4	EYA transcriptional coactivator and phosphatase 4	98928	0.07
chr5_111725288_111725497	12.96	Gm26897	predicted gene, 26897	8532	0.19
chr2_60654945_60655277	12.96	Itgb6	integrin beta 6	18582	0.2
chr2_94246412_94247550	12.96	Mir670hg	MIR670 host gene (non-protein coding)	3643	0.17
chr1_31233663_31234000	12.94	Pih1d3	PIH1 domain containing 3	10993	0.12
chr12_51081982_51082133	12.93	Gm22088	predicted gene, 22088	3630	0.28
chr1_57862082_57862411	12.92	Spats2l	spermatogenesis associated, serine-rich 2-like	16675	0.22
chr13_85067648_85067905	12.92	Gm47745	predicted gene, 47745	26559	0.17

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Isl1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
15.5	62.1	GO:0071205	protein localization to juxtaparanode region of axon(GO:0071205)
9.9	29.8	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
9.1	27.4	GO:0043490	malate-aspartate shuttle(GO:0043490)
8.9	26.6	GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
8.7	26.2	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
8.4	33.5	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
7.3	51.3	GO:0016198	axon choice point recognition(GO:0016198)
6.8	20.4	GO:0003358	noradrenergic neuron development(GO:0003358)
5.8	17.5	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
5.6	16.7	GO:0060178	regulation of exocyst localization(GO:0060178)
5.3	21.2	GO:0036135	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
4.7	14.1	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
4.6	13.9	GO:0070649	formin-nucleated actin cable assembly(GO:0070649)
4.6	4.6	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
4.5	4.5	GO:0097106	postsynaptic density organization(GO:0097106) postsynaptic density assembly(GO:0097107)
4.2	21.2	GO:0021764	amygdala development(GO:0021764)
4.2	16.6	GO:0016576	histone dephosphorylation(GO:0016576)
4.0	12.0	GO:0032289	central nervous system myelin formation(GO:0032289)
4.0	31.8	GO:0021796	cerebral cortex regionalization(GO:0021796)
3.9	15.6	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
3.9	11.6	GO:0097105	presynaptic membrane assembly(GO:0097105)
3.8	11.5	GO:2001170	negative regulation of ATP biosynthetic process(GO:2001170)
3.8	7.6	GO:0061642	chemoattraction of axon(GO:0061642)
3.8	18.9	GO:1902308	regulation of peptidyl-serine dephosphorylation(GO:1902308)
3.8	15.1	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
3.7	11.2	GO:0072240	distal convoluted tubule development(GO:0072025) DCT cell differentiation(GO:0072069) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) metanephric DCT cell differentiation(GO:0072240)
3.7	18.6	GO:0071698	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
3.7	11.1	GO:0003357	noradrenergic neuron differentiation(GO:0003357)
3.7	11.0	GO:0007525	somatic muscle development(GO:0007525)
3.6	10.7	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
3.6	32.2	GO:0021859	pyramidal neuron differentiation(GO:0021859)
3.5	17.6	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
3.5	13.9	GO:0007258	JUN phosphorylation(GO:0007258)
3.4	10.3	GO:0030070	insulin processing(GO:0030070)
3.4	20.6	GO:0071625	vocalization behavior(GO:0071625)
3.4	10.1	GO:0060221	retinal rod cell differentiation(GO:0060221)
3.4	10.1	GO:0097477	lateral motor column neuron migration(GO:0097477)
3.3	3.3	GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998)
3.2	13.0	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
3.2	9.7	GO:0034093	positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
3.2	9.6	GO:0098904	regulation of AV node cell action potential(GO:0098904)
3.2	12.8	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
3.2	12.7	GO:0098598	vocal learning(GO:0042297) imitative learning(GO:0098596) learned vocalization behavior or vocal learning(GO:0098598)
3.2	9.5	GO:0006842	tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
3.2	15.8	GO:1902866	regulation of retina development in camera-type eye(GO:1902866)
3.1	3.1	GO:0097475	motor neuron migration(GO:0097475) spinal cord motor neuron migration(GO:0097476)
3.1	24.7	GO:0021830	interneuron migration from the subpallium to the cortex(GO:0021830)
3.0	3.0	GO:0021861	forebrain radial glial cell differentiation(GO:0021861) auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974)
3.0	21.2	GO:0045161	neuronal ion channel clustering(GO:0045161)
3.0	9.0	GO:0035106	operant conditioning(GO:0035106)
3.0	18.0	GO:0090273	regulation of somatostatin secretion(GO:0090273)
3.0	6.0	GO:0090210	regulation of establishment of blood-brain barrier(GO:0090210)
3.0	3.0	GO:0021773	striatal medium spiny neuron differentiation(GO:0021773)
3.0	11.9	GO:0070366	regulation of hepatocyte differentiation(GO:0070366)
2.9	2.9	GO:0022038	corpus callosum development(GO:0022038)
2.9	8.8	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
2.8	16.8	GO:0098828	modulation of inhibitory postsynaptic potential(GO:0098828)
2.8	8.4	GO:0060594	mammary gland specification(GO:0060594)
2.8	8.4	GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
2.8	13.8	GO:0097113	AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
2.7	8.1	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
2.7	8.1	GO:0071503	response to heparin(GO:0071503) cellular response to heparin(GO:0071504)
2.7	18.8	GO:0014054	positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
2.6	10.4	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
2.5	7.4	GO:0099558	maintenance of synapse structure(GO:0099558)
2.4	7.3	GO:0021564	vagus nerve development(GO:0021564)
2.4	7.3	GO:1990034	calcium ion export from cell(GO:1990034)
2.4	16.8	GO:0051823	regulation of synapse structural plasticity(GO:0051823)
2.4	4.8	GO:0030382	sperm mitochondrion organization(GO:0030382)
2.4	7.2	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
2.4	7.1	GO:0072092	ureteric bud invasion(GO:0072092)
2.4	2.4	GO:0021631	optic nerve morphogenesis(GO:0021631)
2.3	2.3	GO:0021550	medulla oblongata development(GO:0021550)
2.3	7.0	GO:2000686	regulation of rubidium ion transmembrane transporter activity(GO:2000686)
2.3	9.2	GO:0060513	prostatic bud formation(GO:0060513)
2.3	6.9	GO:0072051	juxtaglomerular apparatus development(GO:0072051)
2.3	4.5	GO:0060112	generation of ovulation cycle rhythm(GO:0060112)
2.3	6.8	GO:0060454	positive regulation of gastric acid secretion(GO:0060454)
2.2	2.2	GO:1900451	positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
2.2	49.2	GO:0035418	protein localization to synapse(GO:0035418)
2.2	20.0	GO:0060080	inhibitory postsynaptic potential(GO:0060080)
2.2	6.6	GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
2.2	6.5	GO:0072578	neurotransmitter-gated ion channel clustering(GO:0072578) gamma-aminobutyric acid receptor clustering(GO:0097112)
2.2	6.5	GO:0097155	fasciculation of sensory neuron axon(GO:0097155)
2.1	2.1	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
2.1	8.3	GO:0043587	tongue morphogenesis(GO:0043587)
2.1	2.1	GO:1904861	excitatory synapse assembly(GO:1904861)
2.0	12.2	GO:0032049	cardiolipin biosynthetic process(GO:0032049)
2.0	16.3	GO:0050957	equilibrioception(GO:0050957)
2.0	12.2	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
2.0	4.1	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
2.0	2.0	GO:0097212	lysosomal membrane organization(GO:0097212)
2.0	10.1	GO:0045113	regulation of integrin biosynthetic process(GO:0045113)
2.0	6.0	GO:0033563	dorsal/ventral axon guidance(GO:0033563)
2.0	7.9	GO:0034047	regulation of protein phosphatase type 2A activity(GO:0034047)
2.0	7.9	GO:1903887	motile primary cilium assembly(GO:1903887)
2.0	11.7	GO:0021559	trigeminal nerve development(GO:0021559)
1.9	5.8	GO:0034729	histone H3-K79 methylation(GO:0034729)
1.9	5.8	GO:0001927	exocyst assembly(GO:0001927)
1.9	3.9	GO:0061366	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
1.9	11.6	GO:1901897	regulation of relaxation of cardiac muscle(GO:1901897)
1.9	5.8	GO:0045897	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
1.9	5.7	GO:0030035	microspike assembly(GO:0030035)
1.9	5.7	GO:0072318	clathrin coat disassembly(GO:0072318)
1.9	13.3	GO:0005513	detection of calcium ion(GO:0005513)
1.9	5.6	GO:1901529	positive regulation of anion channel activity(GO:1901529)
1.9	31.8	GO:0071475	cellular hyperosmotic salinity response(GO:0071475)
1.9	1.9	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
1.9	1.9	GO:1900019	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
1.8	9.1	GO:0019532	oxalate transport(GO:0019532)
1.8	1.8	GO:1902669	positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of axon guidance(GO:1902669)
1.8	16.2	GO:0021542	dentate gyrus development(GO:0021542)
1.8	10.6	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
1.8	7.1	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
1.8	5.3	GO:0070458	detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
1.8	5.3	GO:0060584	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
1.7	7.0	GO:0014816	skeletal muscle satellite cell differentiation(GO:0014816)
1.7	3.5	GO:0034182	regulation of maintenance of sister chromatid cohesion(GO:0034091) regulation of maintenance of mitotic sister chromatid cohesion(GO:0034182)
1.7	5.2	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
1.7	5.2	GO:2000599	regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
1.7	5.1	GO:0019249	lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
1.7	6.8	GO:0060279	positive regulation of ovulation(GO:0060279)
1.7	11.9	GO:0045199	maintenance of epithelial cell apical/basal polarity(GO:0045199)
1.7	18.8	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)
1.7	25.2	GO:0016082	synaptic vesicle priming(GO:0016082)
1.7	5.0	GO:0035262	gonad morphogenesis(GO:0035262)
1.6	6.6	GO:0002051	osteoblast fate commitment(GO:0002051)
1.6	4.9	GO:0002314	germinal center B cell differentiation(GO:0002314)
1.6	9.8	GO:0086014	atrial cardiac muscle cell action potential(GO:0086014) atrial cardiac muscle cell to AV node cell signaling(GO:0086026) atrial cardiac muscle cell to AV node cell communication(GO:0086066)
1.6	1.6	GO:0003433	chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
1.6	8.2	GO:0021707	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.6	4.9	GO:0046532	regulation of photoreceptor cell differentiation(GO:0046532)
1.6	3.2	GO:0097091	synaptic vesicle clustering(GO:0097091)
1.6	11.2	GO:0060124	positive regulation of growth hormone secretion(GO:0060124)
1.6	11.0	GO:0060539	diaphragm development(GO:0060539)
1.6	7.8	GO:1902774	late endosome to lysosome transport(GO:1902774)
1.6	4.7	GO:0007638	mechanosensory behavior(GO:0007638)
1.6	3.1	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)
1.5	4.6	GO:0006597	spermine biosynthetic process(GO:0006597)
1.5	9.2	GO:0090244	Wnt signaling pathway involved in somitogenesis(GO:0090244)
1.5	15.3	GO:0071803	positive regulation of podosome assembly(GO:0071803)
1.5	82.2	GO:0051965	positive regulation of synapse assembly(GO:0051965)
1.5	7.6	GO:0035331	negative regulation of hippo signaling(GO:0035331)
1.5	4.5	GO:1900368	regulation of RNA interference(GO:1900368)
1.5	3.0	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.5	28.6	GO:0061049	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.5	3.0	GO:2001055	positive regulation of mesenchymal cell apoptotic process(GO:2001055)
1.5	5.9	GO:0014042	positive regulation of neuron maturation(GO:0014042)
1.4	14.5	GO:0097094	craniofacial suture morphogenesis(GO:0097094)
1.4	1.4	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
1.4	4.3	GO:1902953	positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
1.4	1.4	GO:0061341	non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
1.4	7.0	GO:1902913	positive regulation of neuroepithelial cell differentiation(GO:1902913)
1.4	5.6	GO:0048664	neuron fate determination(GO:0048664)
1.4	2.8	GO:0090135	actin filament branching(GO:0090135)
1.4	5.6	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
1.4	4.2	GO:0060266	negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
1.4	5.5	GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
1.4	4.1	GO:0033693	neurofilament bundle assembly(GO:0033693)
1.4	5.5	GO:0006041	glucosamine metabolic process(GO:0006041)
1.4	104.3	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.4	12.3	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)
1.4	2.7	GO:1900222	negative regulation of beta-amyloid clearance(GO:1900222)
1.4	2.7	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
1.4	4.1	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
1.4	6.8	GO:0030432	peristalsis(GO:0030432)
1.3	2.7	GO:0097623	potassium ion export across plasma membrane(GO:0097623)
1.3	5.4	GO:0090037	positive regulation of protein kinase C signaling(GO:0090037)
1.3	10.7	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
1.3	2.6	GO:0071435	potassium ion export(GO:0071435)
1.3	6.6	GO:0032224	positive regulation of synaptic transmission, cholinergic(GO:0032224)
1.3	5.2	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
1.3	3.9	GO:0042231	interleukin-13 biosynthetic process(GO:0042231)
1.3	2.6	GO:0021553	olfactory nerve development(GO:0021553)
1.3	3.9	GO:0070634	transepithelial ammonium transport(GO:0070634)
1.3	3.9	GO:0014732	skeletal muscle atrophy(GO:0014732)
1.3	10.4	GO:2000671	regulation of motor neuron apoptotic process(GO:2000671)
1.3	5.1	GO:0031642	negative regulation of myelination(GO:0031642)
1.3	3.8	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
1.3	3.8	GO:0021563	glossopharyngeal nerve development(GO:0021563)
1.3	5.1	GO:0043313	regulation of neutrophil degranulation(GO:0043313)
1.3	3.8	GO:0010360	negative regulation of anion channel activity(GO:0010360)
1.3	3.8	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
1.2	1.2	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
1.2	7.5	GO:0002087	regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
1.2	2.5	GO:0046881	positive regulation of follicle-stimulating hormone secretion(GO:0046881)
1.2	1.2	GO:1901671	positive regulation of superoxide dismutase activity(GO:1901671) positive regulation of removal of superoxide radicals(GO:1904833)
1.2	3.7	GO:0007158	neuron cell-cell adhesion(GO:0007158)
1.2	2.4	GO:0060166	olfactory pit development(GO:0060166)
1.2	8.6	GO:0006108	malate metabolic process(GO:0006108)
1.2	2.4	GO:1903899	positive regulation of PERK-mediated unfolded protein response(GO:1903899)
1.2	3.7	GO:1903347	negative regulation of bicellular tight junction assembly(GO:1903347)
1.2	4.9	GO:0031394	positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
1.2	4.8	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
1.2	4.8	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
1.2	9.5	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
1.2	2.4	GO:0097070	ductus arteriosus closure(GO:0097070)
1.2	2.4	GO:0014717	regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
1.2	2.4	GO:0038026	reelin-mediated signaling pathway(GO:0038026)
1.2	2.4	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity(GO:0035509)
1.2	5.9	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
1.2	8.2	GO:0090036	regulation of protein kinase C signaling(GO:0090036)
1.2	14.0	GO:0016486	peptide hormone processing(GO:0016486)
1.2	1.2	GO:0060523	prostate epithelial cord elongation(GO:0060523)
1.2	7.0	GO:0070314	G1 to G0 transition(GO:0070314)
1.2	2.3	GO:0090296	regulation of mitochondrial DNA replication(GO:0090296)
1.2	2.3	GO:2000587	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
1.2	3.5	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
1.1	2.3	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
1.1	9.0	GO:2000010	positive regulation of protein localization to cell surface(GO:2000010)
1.1	3.4	GO:0052203	modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
1.1	3.4	GO:0023041	neuronal signal transduction(GO:0023041)
1.1	3.3	GO:0060437	lung growth(GO:0060437)
1.1	2.2	GO:0042940	D-amino acid transport(GO:0042940)
1.1	3.3	GO:2000002	negative regulation of DNA damage checkpoint(GO:2000002)
1.1	13.3	GO:0051654	establishment of mitochondrion localization(GO:0051654)
1.1	1.1	GO:0021825	cerebral cortex tangential migration using cell-axon interactions(GO:0021824) substrate-dependent cerebral cortex tangential migration(GO:0021825) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) neural crest cell migration involved in autonomic nervous system development(GO:1901166) facioacoustic ganglion development(GO:1903375) dorsal root ganglion development(GO:1990791)
1.1	2.2	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
1.1	4.3	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
1.1	3.2	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
1.1	7.5	GO:0035641	locomotory exploration behavior(GO:0035641)
1.1	6.5	GO:0006642	triglyceride mobilization(GO:0006642)
1.1	18.3	GO:0001964	startle response(GO:0001964)
1.1	5.4	GO:1903215	negative regulation of protein targeting to mitochondrion(GO:1903215)
1.1	2.1	GO:0048715	negative regulation of oligodendrocyte differentiation(GO:0048715)
1.1	6.4	GO:0070571	negative regulation of neuron projection regeneration(GO:0070571)
1.1	5.3	GO:0009235	cobalamin metabolic process(GO:0009235)
1.1	2.1	GO:0001757	somite specification(GO:0001757)
1.1	3.2	GO:0051684	maintenance of Golgi location(GO:0051684)
1.1	4.2	GO:0042473	outer ear morphogenesis(GO:0042473)
1.1	6.4	GO:0060179	male mating behavior(GO:0060179)
1.1	10.6	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
1.0	3.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
1.0	2.1	GO:0016479	negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
1.0	2.1	GO:0046098	guanine metabolic process(GO:0046098)
1.0	3.1	GO:0032304	negative regulation of icosanoid secretion(GO:0032304)
1.0	8.0	GO:0048672	positive regulation of collateral sprouting(GO:0048672)
1.0	2.0	GO:0043396	corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
1.0	3.0	GO:0061589	calcium activated phosphatidylserine scrambling(GO:0061589)
1.0	7.0	GO:0061003	positive regulation of dendritic spine morphogenesis(GO:0061003)
1.0	7.0	GO:0036006	response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006)
1.0	1.0	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
1.0	1.0	GO:2001016	positive regulation of skeletal muscle cell differentiation(GO:2001016)
1.0	3.9	GO:0048007	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
1.0	3.0	GO:1904667	negative regulation of ubiquitin protein ligase activity(GO:1904667)
1.0	5.9	GO:0090527	actin filament reorganization(GO:0090527)
1.0	2.9	GO:0045964	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
1.0	2.0	GO:0035826	rubidium ion transport(GO:0035826)
1.0	6.8	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
1.0	3.9	GO:1903961	positive regulation of anion transmembrane transport(GO:1903961)
1.0	3.9	GO:0033564	anterior/posterior axon guidance(GO:0033564)
1.0	2.9	GO:0060060	post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
1.0	2.9	GO:0030327	prenylated protein catabolic process(GO:0030327)
1.0	6.7	GO:2000254	regulation of male germ cell proliferation(GO:2000254)
1.0	1.0	GO:0010982	regulation of high-density lipoprotein particle clearance(GO:0010982)
0.9	3.8	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.9	2.8	GO:0034628	nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.9	2.8	GO:2000195	negative regulation of female gonad development(GO:2000195)
0.9	1.9	GO:0035815	positive regulation of renal sodium excretion(GO:0035815)
0.9	0.9	GO:0061110	dense core granule biogenesis(GO:0061110)
0.9	6.5	GO:0032291	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.9	3.7	GO:0021877	forebrain neuron fate commitment(GO:0021877)
0.9	2.7	GO:0017198	N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.9	5.5	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.9	2.7	GO:0010046	response to mycotoxin(GO:0010046)
0.9	1.8	GO:0070100	negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.9	0.9	GO:0006113	fermentation(GO:0006113) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) negative regulation of purine nucleotide catabolic process(GO:0033122) regulation of fermentation(GO:0043465) regulation of NAD metabolic process(GO:1902688) regulation of glucose catabolic process to lactate via pyruvate(GO:1904023)
0.9	1.8	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.9	1.8	GO:0086036	regulation of cardiac muscle cell membrane potential(GO:0086036)
0.9	5.4	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.9	3.6	GO:0071694	protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.9	22.2	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
0.9	74.4	GO:0007612	learning(GO:0007612)
0.9	2.7	GO:0003139	secondary heart field specification(GO:0003139)
0.9	15.9	GO:0008045	motor neuron axon guidance(GO:0008045)
0.9	1.8	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.9	3.4	GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.9	8.5	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.8	2.5	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.8	1.7	GO:0060923	cardiac muscle cell fate commitment(GO:0060923)
0.8	2.5	GO:0060005	vestibular reflex(GO:0060005)
0.8	2.5	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.8	2.5	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.8	1.7	GO:0060676	ureteric bud formation(GO:0060676)
0.8	2.5	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.8	9.1	GO:0048488	synaptic vesicle endocytosis(GO:0048488)
0.8	2.5	GO:0061511	centriole elongation(GO:0061511)
0.8	6.6	GO:0000712	resolution of meiotic recombination intermediates(GO:0000712)
0.8	1.6	GO:1904502	regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.8	5.7	GO:0021544	subpallium development(GO:0021544)
0.8	0.8	GO:0035022	positive regulation of Rac protein signal transduction(GO:0035022)
0.8	7.2	GO:0001504	neurotransmitter uptake(GO:0001504)
0.8	1.6	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.8	0.8	GO:0072194	kidney smooth muscle tissue development(GO:0072194)
0.8	0.8	GO:1900157	regulation of bone mineralization involved in bone maturation(GO:1900157)
0.8	1.6	GO:0089700	protein kinase D signaling(GO:0089700)
0.8	2.4	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.8	0.8	GO:1902956	regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902956)
0.8	1.6	GO:0051582	positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.8	1.6	GO:0003330	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.8	0.8	GO:0061588	calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.8	1.5	GO:0002322	B cell proliferation involved in immune response(GO:0002322)
0.8	5.3	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272)
0.8	7.6	GO:0050482	arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.8	2.3	GO:0007468	regulation of rhodopsin gene expression(GO:0007468)
0.8	4.5	GO:0070933	histone H4 deacetylation(GO:0070933)
0.7	2.2	GO:0042126	nitrate metabolic process(GO:0042126)
0.7	5.9	GO:0021516	dorsal spinal cord development(GO:0021516)
0.7	2.2	GO:0060399	positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.7	1.5	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.7	0.7	GO:0035934	corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.7	1.5	GO:0010273	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.7	1.5	GO:1901301	regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.7	6.5	GO:0019511	peptidyl-proline hydroxylation(GO:0019511)
0.7	0.7	GO:0021529	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.7	2.1	GO:0032808	lacrimal gland development(GO:0032808)
0.7	1.4	GO:0035907	dorsal aorta development(GO:0035907) dorsal aorta morphogenesis(GO:0035912)
0.7	3.5	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.7	2.1	GO:0001834	trophectodermal cell proliferation(GO:0001834)
0.7	2.1	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.7	2.7	GO:0035428	hexose transmembrane transport(GO:0035428)
0.7	2.1	GO:0002930	trabecular meshwork development(GO:0002930)
0.7	11.6	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.7	3.4	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.7	1.3	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.7	1.3	GO:0060463	lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.7	4.7	GO:0097237	cellular response to toxic substance(GO:0097237)
0.7	2.7	GO:0032836	glomerular basement membrane development(GO:0032836)
0.7	1.3	GO:0071492	cellular response to UV-A(GO:0071492)
0.7	0.7	GO:0072076	nephrogenic mesenchyme development(GO:0072076)
0.7	2.0	GO:1903975	regulation of glial cell migration(GO:1903975)
0.7	12.4	GO:0007628	adult walking behavior(GO:0007628) walking behavior(GO:0090659)
0.7	3.3	GO:0042790	transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.7	13.7	GO:0007215	glutamate receptor signaling pathway(GO:0007215)
0.6	4.5	GO:0036119	response to platelet-derived growth factor(GO:0036119) cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.6	1.9	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.6	2.6	GO:0090261	positive regulation of inclusion body assembly(GO:0090261)
0.6	3.2	GO:0071397	cellular response to cholesterol(GO:0071397)
0.6	1.3	GO:0070253	somatostatin secretion(GO:0070253)
0.6	3.1	GO:2000617	positive regulation of histone H3-K9 acetylation(GO:2000617)
0.6	1.8	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.6	6.7	GO:0036158	outer dynein arm assembly(GO:0036158)
0.6	1.8	GO:1990928	response to amino acid starvation(GO:1990928)
0.6	4.9	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.6	1.8	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.6	3.6	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.6	8.5	GO:0051447	negative regulation of meiotic cell cycle(GO:0051447)
0.6	0.6	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
0.6	0.6	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.6	0.6	GO:0021524	visceral motor neuron differentiation(GO:0021524)
0.6	0.6	GO:0021586	pons maturation(GO:0021586)
0.6	0.6	GO:1900122	positive regulation of receptor binding(GO:1900122)
0.6	1.8	GO:2000623	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.6	1.2	GO:0021548	pons development(GO:0021548)
0.6	2.9	GO:0031339	negative regulation of vesicle fusion(GO:0031339)
0.6	3.5	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.6	1.7	GO:0048852	diencephalon morphogenesis(GO:0048852)
0.6	6.3	GO:0010839	negative regulation of keratinocyte proliferation(GO:0010839)
0.6	0.6	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.6	2.3	GO:0051013	microtubule severing(GO:0051013)
0.6	1.1	GO:1900109	regulation of histone H3-K9 dimethylation(GO:1900109)
0.6	1.1	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.6	2.2	GO:0006742	NADP catabolic process(GO:0006742)
0.6	3.4	GO:0015074	DNA integration(GO:0015074)
0.6	2.2	GO:0090148	membrane fission(GO:0090148)
0.6	15.5	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.6	5.5	GO:0003417	growth plate cartilage development(GO:0003417)
0.6	3.3	GO:1901409	regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.5	1.1	GO:0042414	epinephrine metabolic process(GO:0042414)
0.5	3.8	GO:0006983	ER overload response(GO:0006983)
0.5	2.2	GO:0042138	meiotic DNA double-strand break formation(GO:0042138)
0.5	2.1	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.5	1.6	GO:0018364	peptidyl-glutamine methylation(GO:0018364)
0.5	1.6	GO:0046952	ketone body catabolic process(GO:0046952)
0.5	0.5	GO:1904378	maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.5	0.5	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.5	0.5	GO:0036016	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.5	0.5	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.5	1.5	GO:0034239	regulation of macrophage fusion(GO:0034239)
0.5	1.0	GO:0042253	granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253) regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.5	5.1	GO:0051703	social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.5	1.0	GO:0010940	positive regulation of necrotic cell death(GO:0010940)
0.5	3.0	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.5	3.5	GO:1903608	protein localization to cytoplasmic stress granule(GO:1903608)
0.5	1.0	GO:0061370	testosterone biosynthetic process(GO:0061370)
0.5	1.0	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.5	1.5	GO:0072321	chaperone-mediated protein transport(GO:0072321)
0.5	1.4	GO:0021794	thalamus development(GO:0021794)
0.5	1.9	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.5	1.4	GO:0072695	negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.5	0.9	GO:0090360	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.5	15.5	GO:0006378	mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.5	1.8	GO:0000414	regulation of histone H3-K36 methylation(GO:0000414)
0.5	1.4	GO:0006537	glutamate biosynthetic process(GO:0006537)
0.5	0.9	GO:0072173	metanephric tubule morphogenesis(GO:0072173)
0.4	3.1	GO:0000055	ribosomal large subunit export from nucleus(GO:0000055)
0.4	6.2	GO:0030204	chondroitin sulfate metabolic process(GO:0030204)
0.4	1.3	GO:0019086	late viral transcription(GO:0019086)
0.4	0.9	GO:0009106	lipoate metabolic process(GO:0009106)
0.4	0.4	GO:0032730	positive regulation of interleukin-1 alpha production(GO:0032730)
0.4	0.9	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.4	0.9	GO:0061152	trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.4	6.9	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.4	1.7	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.4	1.3	GO:0046013	regulation of T cell homeostatic proliferation(GO:0046013)
0.4	1.3	GO:0031118	rRNA pseudouridine synthesis(GO:0031118)
0.4	1.7	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.4	3.4	GO:1990118	sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.4	1.7	GO:0030091	protein repair(GO:0030091)
0.4	0.4	GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031585)
0.4	2.5	GO:0007207	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.4	1.2	GO:0006553	lysine metabolic process(GO:0006553)
0.4	0.4	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.4	0.4	GO:0003406	retinal pigment epithelium development(GO:0003406)
0.4	2.4	GO:0051127	positive regulation of actin nucleation(GO:0051127)
0.4	1.6	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.4	0.8	GO:0042538	hyperosmotic salinity response(GO:0042538)
0.4	4.0	GO:0009404	toxin metabolic process(GO:0009404)
0.4	0.8	GO:0014029	neural crest formation(GO:0014029)
0.4	5.2	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.4	1.6	GO:0009181	purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.4	0.4	GO:0021979	hypothalamus cell differentiation(GO:0021979)
0.4	2.8	GO:0007135	meiosis II(GO:0007135)
0.4	0.8	GO:0009996	negative regulation of cell fate specification(GO:0009996)
0.4	1.2	GO:0030421	defecation(GO:0030421)
0.4	1.2	GO:0019747	regulation of isoprenoid metabolic process(GO:0019747)
0.4	1.2	GO:0048341	paraxial mesoderm formation(GO:0048341)
0.4	3.1	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.4	1.6	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.4	1.2	GO:0097343	ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.4	2.3	GO:0042474	middle ear morphogenesis(GO:0042474)
0.4	0.4	GO:0060278	regulation of ovulation(GO:0060278)
0.4	1.2	GO:0000715	nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.4	2.3	GO:0060294	cilium movement involved in cell motility(GO:0060294)
0.4	1.1	GO:0016584	nucleosome positioning(GO:0016584)
0.4	3.0	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.4	0.4	GO:0001546	preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.4	1.5	GO:0061087	positive regulation of histone H3-K27 methylation(GO:0061087)
0.4	1.5	GO:0099500	synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.4	1.5	GO:0003352	regulation of cilium movement(GO:0003352)
0.4	0.4	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.4	0.7	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.4	0.4	GO:1904430	negative regulation of t-circle formation(GO:1904430)
0.4	0.4	GO:0042661	regulation of mesodermal cell fate specification(GO:0042661)
0.4	0.7	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.4	1.5	GO:1904659	glucose transmembrane transport(GO:1904659)
0.4	1.8	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.4	0.4	GO:0002326	B cell lineage commitment(GO:0002326)
0.4	1.4	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.4	1.4	GO:0003416	endochondral bone growth(GO:0003416)
0.4	0.4	GO:0021554	optic nerve development(GO:0021554)
0.4	0.4	GO:0040031	snRNA modification(GO:0040031)
0.4	1.1	GO:2001206	positive regulation of osteoclast development(GO:2001206)
0.3	5.2	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3	2.8	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.3	0.7	GO:0072161	mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.3	1.0	GO:0022417	protein maturation by protein folding(GO:0022417)
0.3	0.7	GO:0048023	positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.3	0.3	GO:1901858	regulation of mitochondrial DNA metabolic process(GO:1901858)
0.3	0.3	GO:0072205	metanephric collecting duct development(GO:0072205)
0.3	1.3	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.3	0.7	GO:0038030	non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030)
0.3	1.0	GO:0006532	aspartate biosynthetic process(GO:0006532)
0.3	5.6	GO:0035137	hindlimb morphogenesis(GO:0035137)
0.3	1.0	GO:0043615	astrocyte cell migration(GO:0043615)
0.3	4.9	GO:0048843	negative regulation of axon extension involved in axon guidance(GO:0048843)
0.3	1.3	GO:0002669	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.3	2.6	GO:0071436	sodium ion export(GO:0071436)
0.3	1.0	GO:0010578	regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.3	0.3	GO:0045404	positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.3	0.6	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.3	1.3	GO:0002063	chondrocyte development(GO:0002063)
0.3	1.3	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.3	0.6	GO:0002730	regulation of dendritic cell cytokine production(GO:0002730)
0.3	1.9	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
0.3	0.9	GO:0060335	positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.3	1.9	GO:0060467	negative regulation of fertilization(GO:0060467)
0.3	1.2	GO:0016560	protein import into peroxisome matrix, docking(GO:0016560)
0.3	0.6	GO:0071372	cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.3	0.9	GO:0000320	re-entry into mitotic cell cycle(GO:0000320)
0.3	4.8	GO:0060122	inner ear receptor stereocilium organization(GO:0060122)
0.3	0.6	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.3	0.9	GO:0000711	meiotic DNA repair synthesis(GO:0000711)
0.3	0.3	GO:0002767	immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.3	1.5	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.3	0.6	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.3	0.9	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.3	0.3	GO:0048143	astrocyte activation(GO:0048143)
0.3	0.6	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.3	0.3	GO:0008065	establishment of blood-nerve barrier(GO:0008065)
0.3	0.9	GO:0014738	regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.3	0.3	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.3	1.4	GO:0070286	axonemal dynein complex assembly(GO:0070286)
0.3	3.7	GO:0008210	estrogen metabolic process(GO:0008210)
0.3	0.6	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.3	2.6	GO:0033617	mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.3	0.3	GO:2000370	positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.3	2.8	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.3	1.6	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.3	1.6	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.3	1.9	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.3	0.5	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.3	1.1	GO:0006627	protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.3	0.3	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.3	1.3	GO:0006528	asparagine metabolic process(GO:0006528)
0.3	0.8	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.3	2.3	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.3	1.3	GO:0018344	protein geranylgeranylation(GO:0018344)
0.3	0.5	GO:0010454	negative regulation of cell fate commitment(GO:0010454)
0.3	0.3	GO:0032048	cardiolipin metabolic process(GO:0032048)
0.3	0.8	GO:0032066	nucleolus to nucleoplasm transport(GO:0032066)
0.3	0.3	GO:0072044	collecting duct development(GO:0072044)
0.3	0.5	GO:0042851	L-alanine metabolic process(GO:0042851)
0.2	0.7	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.2	1.5	GO:0006020	inositol metabolic process(GO:0006020)
0.2	1.7	GO:0060576	intestinal epithelial cell development(GO:0060576)
0.2	0.2	GO:0071481	cellular response to X-ray(GO:0071481)
0.2	0.7	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.2	1.0	GO:0061484	hematopoietic stem cell homeostasis(GO:0061484)
0.2	0.5	GO:0090365	regulation of mRNA modification(GO:0090365)
0.2	0.7	GO:0030167	proteoglycan catabolic process(GO:0030167)
0.2	1.4	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.2	0.7	GO:0035625	receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.2	0.2	GO:0090403	oxidative stress-induced premature senescence(GO:0090403)
0.2	0.9	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.2	1.2	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.2	3.9	GO:2001014	regulation of skeletal muscle cell differentiation(GO:2001014)
0.2	0.2	GO:2000437	monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.2	0.5	GO:2000615	regulation of histone H3-K9 acetylation(GO:2000615)
0.2	0.2	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.2	1.6	GO:0060081	membrane hyperpolarization(GO:0060081)
0.2	0.7	GO:0032474	otolith morphogenesis(GO:0032474)
0.2	2.5	GO:0051532	regulation of NFAT protein import into nucleus(GO:0051532)
0.2	0.7	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.2	0.2	GO:0061091	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.2	0.9	GO:0070528	protein kinase C signaling(GO:0070528)
0.2	0.2	GO:0001880	Mullerian duct regression(GO:0001880)
0.2	1.1	GO:0015808	L-alanine transport(GO:0015808)
0.2	0.4	GO:0090069	regulation of ribosome biogenesis(GO:0090069)
0.2	0.4	GO:0009233	menaquinone metabolic process(GO:0009233)
0.2	2.2	GO:0009226	nucleotide-sugar biosynthetic process(GO:0009226)
0.2	0.6	GO:0039689	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.2	0.2	GO:1902837	amino acid import into cell(GO:1902837)
0.2	0.4	GO:0010571	positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.2	0.4	GO:0002461	tolerance induction dependent upon immune response(GO:0002461)
0.2	0.2	GO:0030908	intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.2	0.2	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.2	0.8	GO:0000054	ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753)
0.2	1.8	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.2	0.8	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.2	0.4	GO:2000553	positive regulation of T-helper 2 cell cytokine production(GO:2000553)
0.2	2.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.2	0.2	GO:0051665	membrane raft localization(GO:0051665)
0.2	0.2	GO:0003344	pericardium morphogenesis(GO:0003344)
0.2	0.2	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.2	0.4	GO:0014043	negative regulation of neuron maturation(GO:0014043)
0.2	0.6	GO:0015755	fructose transport(GO:0015755)
0.2	1.7	GO:0006283	transcription-coupled nucleotide-excision repair(GO:0006283)
0.2	0.6	GO:0045583	regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.2	0.4	GO:0035992	tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.2	0.8	GO:0032596	protein transport into membrane raft(GO:0032596)
0.2	1.1	GO:0010919	regulation of inositol phosphate biosynthetic process(GO:0010919)
0.2	0.6	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.2	0.4	GO:1903207	neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.2	0.9	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.2	0.4	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.2	0.5	GO:0006538	glutamate catabolic process(GO:0006538)
0.2	1.9	GO:0008347	glial cell migration(GO:0008347)
0.2	0.2	GO:0048505	regulation of timing of cell differentiation(GO:0048505)
0.2	0.5	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2	0.2	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.2	0.2	GO:1990168	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.2	5.6	GO:0031110	regulation of microtubule polymerization or depolymerization(GO:0031110)
0.2	0.5	GO:0097029	mature conventional dendritic cell differentiation(GO:0097029)
0.2	0.5	GO:0001827	inner cell mass cell fate commitment(GO:0001827)
0.2	0.5	GO:0060244	negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.2	0.3	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
0.2	2.2	GO:0034587	piRNA metabolic process(GO:0034587)
0.2	0.2	GO:0042420	dopamine catabolic process(GO:0042420)
0.2	0.3	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.2	0.3	GO:2000118	regulation of sodium-dependent phosphate transport(GO:2000118)
0.2	0.7	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.2	0.5	GO:0036123	histone H3-K9 dimethylation(GO:0036123)
0.2	0.8	GO:0051571	positive regulation of histone H3-K4 methylation(GO:0051571)
0.2	0.5	GO:0036289	peptidyl-serine autophosphorylation(GO:0036289)
0.2	0.2	GO:0036301	macrophage colony-stimulating factor production(GO:0036301) granulocyte colony-stimulating factor production(GO:0071611) regulation of granulocyte colony-stimulating factor production(GO:0071655) regulation of macrophage colony-stimulating factor production(GO:1901256)
0.2	0.3	GO:0048865	stem cell fate commitment(GO:0048865)
0.2	0.3	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.2	0.2	GO:0060789	hair follicle placode formation(GO:0060789)
0.2	0.3	GO:0002666	positive regulation of T cell tolerance induction(GO:0002666)
0.2	1.2	GO:0044458	motile cilium assembly(GO:0044458)
0.2	2.0	GO:0030497	fatty acid elongation(GO:0030497)
0.2	0.6	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.2	0.5	GO:0050955	thermoception(GO:0050955)
0.2	0.2	GO:2000381	negative regulation of mesoderm development(GO:2000381)
0.2	0.8	GO:0042428	serotonin metabolic process(GO:0042428)
0.2	1.2	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.1	0.6	GO:0030252	growth hormone secretion(GO:0030252)
0.1	1.3	GO:1900119	positive regulation of execution phase of apoptosis(GO:1900119)
0.1	0.6	GO:0035747	natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501) positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1	0.9	GO:0060292	long term synaptic depression(GO:0060292)
0.1	0.3	GO:0009732	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.1	0.4	GO:0033326	cerebrospinal fluid secretion(GO:0033326)
0.1	0.4	GO:0010166	wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1	0.6	GO:0001963	synaptic transmission, dopaminergic(GO:0001963)
0.1	4.3	GO:0003407	neural retina development(GO:0003407)
0.1	7.0	GO:0099531	presynaptic process involved in chemical synaptic transmission(GO:0099531)
0.1	1.3	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.1	0.1	GO:0031392	regulation of prostaglandin biosynthetic process(GO:0031392) regulation of unsaturated fatty acid biosynthetic process(GO:2001279)
0.1	0.4	GO:0036089	cleavage furrow formation(GO:0036089)
0.1	0.1	GO:0090493	catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.1	0.1	GO:0086029	Purkinje myocyte to ventricular cardiac muscle cell signaling(GO:0086029) Purkinje myocyte to ventricular cardiac muscle cell communication(GO:0086068)
0.1	0.7	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.1	0.1	GO:0002408	myeloid dendritic cell chemotaxis(GO:0002408)
0.1	0.4	GO:0035627	ceramide transport(GO:0035627)
0.1	0.1	GO:0060024	rhythmic synaptic transmission(GO:0060024)
0.1	0.7	GO:0060736	prostate gland growth(GO:0060736)
0.1	0.7	GO:1990564	protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1	0.1	GO:0002877	regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
0.1	0.4	GO:0032610	interleukin-1 alpha production(GO:0032610)
0.1	0.3	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1	0.5	GO:0001955	blood vessel maturation(GO:0001955)
0.1	1.4	GO:1904874	regulation of telomerase RNA localization to Cajal body(GO:1904872) positive regulation of telomerase RNA localization to Cajal body(GO:1904874)
0.1	0.1	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.1	0.4	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)
0.1	0.2	GO:0010966	regulation of phosphate transport(GO:0010966)
0.1	0.1	GO:0021783	preganglionic parasympathetic fiber development(GO:0021783)
0.1	0.5	GO:0071280	cellular response to copper ion(GO:0071280)
0.1	0.4	GO:2000850	negative regulation of steroid hormone secretion(GO:2000832) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.1	0.3	GO:0043576	regulation of respiratory gaseous exchange(GO:0043576)
0.1	0.1	GO:0071639	regulation of interleukin-18 production(GO:0032661) positive regulation of monocyte chemotactic protein-1 production(GO:0071639)
0.1	0.1	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1	0.1	GO:0060120	auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.1	0.2	GO:0090271	positive regulation of fibroblast growth factor production(GO:0090271)
0.1	0.2	GO:1903261	regulation of serine phosphorylation of STAT3 protein(GO:1903261)
0.1	1.5	GO:0032981	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1	0.2	GO:0061085	regulation of histone H3-K27 methylation(GO:0061085)
0.1	0.1	GO:1902947	regulation of tau-protein kinase activity(GO:1902947)
0.1	0.1	GO:0060745	mammary gland branching involved in pregnancy(GO:0060745) tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.1	0.2	GO:0021854	hypothalamus development(GO:0021854)
0.1	0.4	GO:0030259	lipid glycosylation(GO:0030259)
0.1	0.8	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.1	0.1	GO:0070460	thyroid-stimulating hormone secretion(GO:0070460)
0.1	0.1	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.1	0.1	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1	0.2	GO:1901535	regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
0.1	0.7	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1	0.3	GO:0033566	gamma-tubulin complex localization(GO:0033566)
0.1	0.1	GO:0033084	regulation of immature T cell proliferation in thymus(GO:0033084)
0.1	0.1	GO:0042222	interleukin-1 biosynthetic process(GO:0042222)
0.1	1.3	GO:0030322	stabilization of membrane potential(GO:0030322)
0.1	0.2	GO:0048318	axial mesoderm development(GO:0048318)
0.1	0.3	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.1	1.0	GO:1900003	regulation of serine-type endopeptidase activity(GO:1900003) negative regulation of serine-type endopeptidase activity(GO:1900004) regulation of serine-type peptidase activity(GO:1902571) negative regulation of serine-type peptidase activity(GO:1902572)
0.1	1.9	GO:0015988	energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1	0.1	GO:0072077	renal vesicle morphogenesis(GO:0072077)
0.1	0.2	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.1	0.1	GO:0014075	response to amine(GO:0014075)
0.1	0.5	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.1	0.3	GO:0060011	Sertoli cell proliferation(GO:0060011)
0.1	0.1	GO:0060459	left lung development(GO:0060459) left lung morphogenesis(GO:0060460)
0.1	0.1	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.1	0.4	GO:0070914	UV-damage excision repair(GO:0070914)
0.1	0.1	GO:0043988	histone H3-S28 phosphorylation(GO:0043988)
0.1	0.1	GO:0000189	MAPK import into nucleus(GO:0000189)
0.1	0.1	GO:0002540	leukotriene production involved in inflammatory response(GO:0002540)
0.1	0.1	GO:0090086	negative regulation of protein deubiquitination(GO:0090086)
0.1	0.2	GO:0002017	regulation of blood volume by renal aldosterone(GO:0002017)
0.1	0.2	GO:0044375	regulation of peroxisome size(GO:0044375)
0.1	0.2	GO:0051901	positive regulation of mitochondrial depolarization(GO:0051901)
0.1	0.1	GO:0071371	cellular response to gonadotropin stimulus(GO:0071371)
0.1	0.2	GO:0055119	relaxation of cardiac muscle(GO:0055119)
0.1	0.3	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.1	0.3	GO:0030638	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.1	0.3	GO:0042346	positive regulation of NF-kappaB import into nucleus(GO:0042346)
0.1	0.4	GO:0007253	cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1	0.3	GO:0017121	phospholipid scrambling(GO:0017121)
0.1	0.2	GO:0050654	chondroitin sulfate proteoglycan metabolic process(GO:0050654)
0.1	0.4	GO:0045945	positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.1	0.1	GO:0043504	mitochondrial DNA repair(GO:0043504)
0.0	0.2	GO:0018211	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.1	GO:0043045	DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0	0.0	GO:0002339	B cell selection(GO:0002339)
0.0	0.0	GO:0060084	synaptic transmission involved in micturition(GO:0060084)
0.0	0.0	GO:0014734	skeletal muscle hypertrophy(GO:0014734)
0.0	0.1	GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0	0.5	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0071847	TNFSF11-mediated signaling pathway(GO:0071847)
0.0	0.1	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654)
0.0	0.0	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.1	GO:0019336	phenol-containing compound catabolic process(GO:0019336)
0.0	0.1	GO:0051697	protein delipidation(GO:0051697)
0.0	0.2	GO:0007616	long-term memory(GO:0007616)
0.0	0.1	GO:0001865	NK T cell differentiation(GO:0001865)
0.0	0.2	GO:0031468	nuclear envelope reassembly(GO:0031468)
0.0	0.0	GO:0015744	succinate transport(GO:0015744)
0.0	0.0	GO:0039692	single stranded viral RNA replication via double stranded DNA intermediate(GO:0039692) regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091) negative regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045869)
0.0	0.1	GO:1901894	regulation of calcium-transporting ATPase activity(GO:1901894)
0.0	0.1	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.0	GO:1900135	positive regulation of renin secretion into blood stream(GO:1900135)
0.0	0.1	GO:2000491	positive regulation of hepatic stellate cell activation(GO:2000491)
0.0	0.0	GO:0038001	paracrine signaling(GO:0038001)
0.0	0.0	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.0	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0010835	regulation of protein ADP-ribosylation(GO:0010835)
0.0	0.8	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0	0.1	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.0	0.1	GO:1904293	negative regulation of ERAD pathway(GO:1904293)
0.0	0.1	GO:0002329	pre-B cell differentiation(GO:0002329)
0.0	0.0	GO:0002254	kinin cascade(GO:0002254)
0.0	0.0	GO:0043382	positive regulation of memory T cell differentiation(GO:0043382)
0.0	0.0	GO:0032276	regulation of gonadotropin secretion(GO:0032276)
0.0	0.0	GO:0050968	detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.0	0.0	GO:1903984	regulation of TRAIL-activated apoptotic signaling pathway(GO:1903121) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
6.6	13.2	GO:0097451	glial limiting end-foot(GO:0097451)
6.5	19.6	GO:0072534	perineuronal net(GO:0072534)
6.1	60.6	GO:0044224	juxtaparanode region of axon(GO:0044224)
5.1	20.4	GO:0033010	paranodal junction(GO:0033010)
4.6	13.7	GO:0097441	basilar dendrite(GO:0097441)
4.5	22.6	GO:0032983	kainate selective glutamate receptor complex(GO:0032983)
4.5	35.8	GO:0042788	polysomal ribosome(GO:0042788)
4.0	15.9	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
3.2	47.8	GO:0031527	filopodium membrane(GO:0031527)
3.1	21.9	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
2.9	29.1	GO:0035253	ciliary rootlet(GO:0035253)
2.8	5.6	GO:0031258	lamellipodium membrane(GO:0031258)
2.6	18.3	GO:0036057	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
2.4	19.6	GO:0043083	synaptic cleft(GO:0043083)
2.4	4.9	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
2.4	9.6	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
2.3	6.8	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
2.3	15.8	GO:0071437	invadopodium(GO:0071437)
2.1	8.4	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
2.1	2.1	GO:0034750	Scrib-APC-beta-catenin complex(GO:0034750)
2.0	4.0	GO:1902710	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
1.9	5.8	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
1.8	47.3	GO:0044295	axonal growth cone(GO:0044295)
1.8	9.0	GO:0048787	presynaptic active zone membrane(GO:0048787)
1.8	7.2	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
1.8	5.4	GO:0070552	BRISC complex(GO:0070552)
1.8	17.9	GO:0043194	axon initial segment(GO:0043194)
1.8	10.5	GO:0044300	cerebellar mossy fiber(GO:0044300)
1.7	44.6	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
1.7	5.0	GO:0097427	microtubule bundle(GO:0097427)
1.6	3.3	GO:0030313	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
1.6	9.8	GO:1990075	periciliary membrane compartment(GO:1990075)
1.6	34.8	GO:0048786	presynaptic active zone(GO:0048786)
1.6	18.7	GO:0071564	npBAF complex(GO:0071564)
1.5	4.5	GO:0005863	striated muscle myosin thick filament(GO:0005863)
1.5	4.5	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
1.5	22.3	GO:0031045	dense core granule(GO:0031045)
1.4	48.8	GO:0042734	presynaptic membrane(GO:0042734)
1.4	18.0	GO:0060077	inhibitory synapse(GO:0060077)
1.3	7.8	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
1.3	5.2	GO:0071598	neuronal ribonucleoprotein granule(GO:0071598)
1.3	5.2	GO:0005593	FACIT collagen trimer(GO:0005593)
1.3	7.7	GO:0032584	growth cone membrane(GO:0032584)
1.3	14.1	GO:0042555	MCM complex(GO:0042555)
1.3	8.9	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
1.2	9.7	GO:0030673	axolemma(GO:0030673)
1.1	3.4	GO:0000322	storage vacuole(GO:0000322)
1.1	10.9	GO:0030877	beta-catenin destruction complex(GO:0030877)
1.1	4.3	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
1.1	8.7	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
1.1	5.3	GO:0005672	transcription factor TFIIA complex(GO:0005672)
1.1	1.1	GO:0097648	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
1.0	164.5	GO:0060076	excitatory synapse(GO:0060076)
1.0	6.2	GO:0016012	sarcoglycan complex(GO:0016012)
1.0	9.9	GO:0030061	mitochondrial crista(GO:0030061)
1.0	3.0	GO:0048179	activin receptor complex(GO:0048179)
0.9	4.5	GO:0097433	dense body(GO:0097433)
0.9	2.7	GO:0071797	LUBAC complex(GO:0071797)
0.9	8.5	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.8	2.5	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.8	2.4	GO:0005608	laminin-3 complex(GO:0005608)
0.8	7.9	GO:1990023	mitotic spindle midzone(GO:1990023)
0.8	2.4	GO:0043511	inhibin complex(GO:0043511)
0.8	7.0	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.8	5.4	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.8	4.5	GO:0072557	IPAF inflammasome complex(GO:0072557)
0.7	3.0	GO:0097209	epidermal lamellar body(GO:0097209)
0.7	17.6	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.7	78.3	GO:0045211	postsynaptic membrane(GO:0045211)
0.7	5.8	GO:0036157	outer dynein arm(GO:0036157)
0.7	37.9	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.7	4.3	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.6	7.8	GO:0031512	motile primary cilium(GO:0031512)
0.6	7.7	GO:0030123	AP-3 adaptor complex(GO:0030123)
0.6	3.2	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.6	1.8	GO:0005955	calcineurin complex(GO:0005955)
0.6	6.0	GO:0032426	stereocilium tip(GO:0032426)
0.6	3.0	GO:0071547	piP-body(GO:0071547)
0.6	0.6	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.6	1.8	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.6	1.7	GO:0070939	Dsl1p complex(GO:0070939)
0.6	2.3	GO:0034448	EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.6	0.6	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.5	1.6	GO:0036396	MIS complex(GO:0036396)
0.5	3.8	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.5	3.2	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.5	3.2	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.5	6.1	GO:0035686	sperm fibrous sheath(GO:0035686)
0.5	4.8	GO:0005687	U4 snRNP(GO:0005687)
0.5	7.0	GO:0043205	fibril(GO:0043205)
0.5	7.2	GO:0005614	interstitial matrix(GO:0005614)
0.5	1.8	GO:0097449	astrocyte projection(GO:0097449)
0.4	1.3	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.4	1.3	GO:0090661	box H/ACA telomerase RNP complex(GO:0090661)
0.4	0.8	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.4	1.2	GO:0000802	transverse filament(GO:0000802)
0.4	1.6	GO:0017071	intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.4	1.2	GO:1990393	3M complex(GO:1990393)
0.4	0.4	GO:0044299	C-fiber(GO:0044299)
0.4	5.2	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.4	8.7	GO:0031941	filamentous actin(GO:0031941)
0.3	4.5	GO:0032809	neuronal cell body membrane(GO:0032809)
0.3	1.0	GO:0030891	VCB complex(GO:0030891)
0.3	5.4	GO:0042101	T cell receptor complex(GO:0042101)
0.3	1.7	GO:0044613	nuclear pore central transport channel(GO:0044613)
0.3	4.0	GO:0031597	cytosolic proteasome complex(GO:0031597)
0.3	3.0	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.3	2.3	GO:0031209	SCAR complex(GO:0031209)
0.3	1.0	GO:0032280	symmetric synapse(GO:0032280)
0.3	0.3	GO:0034715	pICln-Sm protein complex(GO:0034715)
0.3	6.8	GO:0034451	centriolar satellite(GO:0034451)
0.3	0.9	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.3	3.5	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.3	1.1	GO:0070876	SOSS complex(GO:0070876)
0.3	0.8	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.3	3.6	GO:0036038	MKS complex(GO:0036038)
0.3	0.8	GO:0071942	XPC complex(GO:0071942)
0.3	0.8	GO:0070110	ciliary neurotrophic factor receptor complex(GO:0070110)
0.3	1.3	GO:0045098	type III intermediate filament(GO:0045098)
0.2	2.0	GO:0043020	NADPH oxidase complex(GO:0043020)
0.2	1.2	GO:0001940	male pronucleus(GO:0001940)
0.2	0.7	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.2	1.2	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.2	0.7	GO:0043293	apoptosome(GO:0043293)
0.2	0.9	GO:0071817	MMXD complex(GO:0071817)
0.2	0.9	GO:1990246	uniplex complex(GO:1990246)
0.2	0.8	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.2	1.0	GO:0090543	Flemming body(GO:0090543)
0.2	1.2	GO:0000439	core TFIIH complex(GO:0000439)
0.2	0.6	GO:0035061	interchromatin granule(GO:0035061)
0.2	4.1	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.2	0.6	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2	0.6	GO:0070761	pre-snoRNP complex(GO:0070761)
0.2	2.0	GO:0042405	nuclear inclusion body(GO:0042405)
0.2	0.5	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.2	4.1	GO:0032420	stereocilium(GO:0032420)
0.2	0.5	GO:0034457	Mpp10 complex(GO:0034457)
0.2	2.6	GO:0070822	Sin3-type complex(GO:0070822)
0.2	1.0	GO:0044292	dendrite terminus(GO:0044292)
0.2	5.9	GO:0030175	filopodium(GO:0030175)
0.2	0.8	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.2	0.6	GO:0032021	NELF complex(GO:0032021)
0.1	2.4	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.1	1.1	GO:0031211	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	0.4	GO:0005899	insulin receptor complex(GO:0005899)
0.1	1.2	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.1	1.4	GO:0097440	apical dendrite(GO:0097440)
0.1	1.6	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.1	0.1	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.1	0.4	GO:0030289	protein phosphatase 4 complex(GO:0030289)
0.1	0.3	GO:0070531	BRCA1-A complex(GO:0070531)
0.1	3.1	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1	0.3	GO:0017133	mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1	5.7	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	0.2	GO:0033647	host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648)
0.1	4.7	GO:0001533	cornified envelope(GO:0001533)
0.1	0.1	GO:0005879	axonemal microtubule(GO:0005879)
0.1	0.5	GO:0070847	core mediator complex(GO:0070847)
0.1	3.8	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.1	0.2	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	1.1	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	0.5	GO:0070187	telosome(GO:0070187)
0.1	0.2	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.1	0.4	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	0.2	GO:0042827	platelet dense granule(GO:0042827)
0.1	0.5	GO:0071006	U2-type catalytic step 1 spliceosome(GO:0071006)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.2	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0055087	Ski complex(GO:0055087)
0.0	0.3	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.0	GO:0035838	growing cell tip(GO:0035838)
0.0	0.1	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0	0.5	GO:0005922	connexon complex(GO:0005922)
0.0	0.1	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0008274	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0	0.0	GO:0043202	lysosomal lumen(GO:0043202)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
8.9	26.6	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
7.1	21.4	GO:0070699	type II activin receptor binding(GO:0070699)
7.1	28.5	GO:0035727	lysophosphatidic acid binding(GO:0035727)
6.2	31.2	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
5.8	23.2	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
5.5	16.4	GO:0097109	neuroligin family protein binding(GO:0097109)
4.9	24.4	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
4.7	9.4	GO:0015137	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
4.4	13.2	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
4.4	21.8	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
4.1	28.7	GO:0003680	AT DNA binding(GO:0003680)
3.9	23.2	GO:0034190	apolipoprotein receptor binding(GO:0034190)
3.6	7.1	GO:0045503	dynein light chain binding(GO:0045503)
3.4	13.4	GO:0005030	neurotrophin receptor activity(GO:0005030)
3.2	9.5	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
2.9	8.8	GO:0004351	glutamate decarboxylase activity(GO:0004351)
2.7	24.3	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313)
2.6	5.3	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
2.6	7.7	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
2.6	7.7	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
2.5	10.0	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
2.4	7.3	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
2.4	9.5	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
2.4	4.7	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
2.2	6.7	GO:0097016	L27 domain binding(GO:0097016)
2.2	6.5	GO:0004995	tachykinin receptor activity(GO:0004995)
2.1	10.5	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004)
2.1	8.3	GO:0070878	primary miRNA binding(GO:0070878)
2.0	6.1	GO:1990430	extracellular matrix protein binding(GO:1990430)
2.0	2.0	GO:0015185	gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
2.0	6.0	GO:0050816	phosphothreonine binding(GO:0050816)
2.0	39.5	GO:0017075	syntaxin-1 binding(GO:0017075)
2.0	7.9	GO:0032051	clathrin light chain binding(GO:0032051)
1.9	11.7	GO:0048495	Roundabout binding(GO:0048495)
1.9	7.7	GO:0031544	peptidyl-proline 3-dioxygenase activity(GO:0031544)
1.8	20.2	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.8	10.9	GO:0008046	axon guidance receptor activity(GO:0008046)
1.8	19.9	GO:0005234	extracellular-glutamate-gated ion channel activity(GO:0005234)
1.8	7.2	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
1.8	7.2	GO:0043262	adenosine-diphosphatase activity(GO:0043262)
1.8	9.0	GO:0004385	guanylate kinase activity(GO:0004385)
1.8	14.3	GO:0008599	protein phosphatase type 1 regulator activity(GO:0008599)
1.8	3.5	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
1.7	7.0	GO:0008502	melatonin receptor activity(GO:0008502)
1.7	1.7	GO:0016880	acid-ammonia (or amide) ligase activity(GO:0016880)
1.7	5.2	GO:0005483	soluble NSF attachment protein activity(GO:0005483)
1.7	38.0	GO:0045499	chemorepellent activity(GO:0045499)
1.6	4.9	GO:0017002	activin-activated receptor activity(GO:0017002)
1.6	3.3	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
1.6	4.9	GO:0031708	endothelin B receptor binding(GO:0031708)
1.6	4.8	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
1.6	7.9	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
1.6	6.3	GO:0001602	pancreatic polypeptide receptor activity(GO:0001602)
1.6	18.9	GO:0003905	alkylbase DNA N-glycosylase activity(GO:0003905) DNA-3-methylbase glycosylase activity(GO:0043733)
1.5	6.2	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
1.5	7.4	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
1.5	4.4	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
1.4	2.9	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
1.4	7.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
1.4	5.7	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
1.4	11.3	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
1.4	7.0	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
1.4	7.0	GO:0004985	opioid receptor activity(GO:0004985)
1.4	5.6	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
1.4	5.5	GO:0001642	group III metabotropic glutamate receptor activity(GO:0001642)
1.4	6.9	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
1.3	12.1	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
1.3	2.6	GO:0043199	sulfate binding(GO:0043199)
1.3	2.6	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
1.3	8.9	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
1.2	3.7	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
1.2	3.7	GO:0008240	tripeptidyl-peptidase activity(GO:0008240)
1.2	28.8	GO:0017091	AU-rich element binding(GO:0017091)
1.2	6.0	GO:0042609	CD4 receptor binding(GO:0042609)
1.2	7.2	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
1.2	4.8	GO:0038064	collagen receptor activity(GO:0038064)
1.2	3.6	GO:0003708	retinoic acid receptor activity(GO:0003708)
1.2	3.6	GO:0035673	oligopeptide transmembrane transporter activity(GO:0035673)
1.1	3.4	GO:0004470	malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471)
1.1	4.5	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
1.1	4.4	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
1.1	2.2	GO:0098821	BMP receptor activity(GO:0098821)
1.1	2.2	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
1.1	5.4	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
1.1	7.6	GO:0005138	interleukin-6 receptor binding(GO:0005138)
1.1	1.1	GO:0038191	neuropilin binding(GO:0038191)
1.1	5.4	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
1.1	4.3	GO:0005042	netrin receptor activity(GO:0005042)
1.1	1.1	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
1.1	5.3	GO:0004957	prostaglandin E receptor activity(GO:0004957)
1.0	21.0	GO:0071837	HMG box domain binding(GO:0071837)
1.0	5.2	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
1.0	11.2	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
1.0	6.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
1.0	9.0	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
1.0	3.0	GO:0004359	glutaminase activity(GO:0004359)
1.0	13.6	GO:0016500	protein-hormone receptor activity(GO:0016500)
1.0	2.9	GO:0031802	type 5 metabotropic glutamate receptor binding(GO:0031802)
0.9	2.8	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.9	2.8	GO:0030158	protein xylosyltransferase activity(GO:0030158)
0.9	3.7	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.9	10.2	GO:0042043	neurexin family protein binding(GO:0042043)
0.9	16.6	GO:0004890	GABA-A receptor activity(GO:0004890)
0.9	2.7	GO:1990189	peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.9	4.4	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.9	2.7	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.9	21.2	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.9	5.2	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.8	11.7	GO:0016805	dipeptidase activity(GO:0016805)
0.8	5.0	GO:0035473	lipase binding(GO:0035473)
0.8	2.5	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.8	8.8	GO:0044606	thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.8	3.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.8	4.7	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.8	28.3	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.8	3.0	GO:0034618	arginine binding(GO:0034618)
0.8	3.0	GO:0004969	histamine receptor activity(GO:0004969)
0.7	2.2	GO:0035851	Krueppel-associated box domain binding(GO:0035851)
0.7	3.6	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.7	6.4	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.7	1.4	GO:0035939	microsatellite binding(GO:0035939)
0.7	4.9	GO:0002151	G-quadruplex RNA binding(GO:0002151)
0.7	2.0	GO:0016917	GABA receptor activity(GO:0016917)
0.7	5.4	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.7	4.0	GO:0030274	LIM domain binding(GO:0030274)
0.7	5.4	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.7	6.6	GO:0015026	coreceptor activity(GO:0015026)
0.7	15.7	GO:0034840	C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.7	3.9	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.7	5.2	GO:0005452	inorganic anion exchanger activity(GO:0005452)
0.6	1.9	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.6	1.9	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.6	1.9	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.6	20.0	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.6	5.6	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.6	7.3	GO:0031402	sodium ion binding(GO:0031402)
0.6	1.2	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.6	2.4	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.6	4.2	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.6	6.5	GO:0008179	adenylate cyclase binding(GO:0008179)
0.6	2.9	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.6	2.3	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.6	2.3	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.6	1.2	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.6	3.5	GO:0031628	opioid receptor binding(GO:0031628)
0.6	9.3	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.6	6.3	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.6	2.3	GO:0034711	inhibin binding(GO:0034711)
0.6	5.1	GO:0103116	alpha-D-galactofuranose transporter activity(GO:0103116)
0.6	10.8	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.6	15.1	GO:0052770	coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.6	2.2	GO:0034056	estrogen response element binding(GO:0034056)
0.6	1.7	GO:0061665	SUMO ligase activity(GO:0061665)
0.5	2.7	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.5	13.6	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.5	2.7	GO:0017040	ceramidase activity(GO:0017040)
0.5	2.2	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.5	15.0	GO:0035254	glutamate receptor binding(GO:0035254)
0.5	3.2	GO:0070191	methionine-R-sulfoxide reductase activity(GO:0070191)
0.5	1.6	GO:0008260	3-oxoacid CoA-transferase activity(GO:0008260)
0.5	13.0	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.5	1.0	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.5	1.0	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.5	7.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.5	1.5	GO:0008384	IkappaB kinase activity(GO:0008384)
0.5	11.1	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.5	3.0	GO:0036402	proteasome-activating ATPase activity(GO:0036402)
0.5	11.0	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.5	1.5	GO:0032357	oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357)
0.5	1.5	GO:0001030	RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084)
0.5	1.5	GO:0035650	AP-1 adaptor complex binding(GO:0035650)
0.5	2.5	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.5	1.4	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.5	0.5	GO:0048408	epidermal growth factor binding(GO:0048408)
0.5	0.9	GO:0098988	G-protein coupled glutamate receptor activity(GO:0098988)
0.5	2.3	GO:0004565	beta-galactosidase activity(GO:0004565)
0.5	2.7	GO:0030249	guanylate cyclase regulator activity(GO:0030249)
0.5	0.9	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.4	5.3	GO:0070034	telomerase RNA binding(GO:0070034)
0.4	1.3	GO:0005148	prolactin receptor binding(GO:0005148)
0.4	7.9	GO:0042056	chemoattractant activity(GO:0042056)
0.4	2.6	GO:0004534	5'-3' exoribonuclease activity(GO:0004534)
0.4	1.7	GO:0032564	dATP binding(GO:0032564)
0.4	2.1	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.4	4.7	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.4	5.1	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.4	1.3	GO:0019959	interleukin-8 binding(GO:0019959)
0.4	1.3	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.4	2.8	GO:0035613	RNA stem-loop binding(GO:0035613)
0.4	2.0	GO:0004994	somatostatin receptor activity(GO:0004994)
0.4	1.2	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.4	1.6	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.4	1.9	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758)
0.4	11.6	GO:0017147	Wnt-protein binding(GO:0017147)
0.4	1.5	GO:0051185	coenzyme transporter activity(GO:0051185)
0.4	1.2	GO:0016015	morphogen activity(GO:0016015)
0.4	3.1	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.4	6.8	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.4	2.2	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.4	0.7	GO:0019211	phosphatase activator activity(GO:0019211)
0.4	0.7	GO:0016595	glutamate binding(GO:0016595)
0.4	1.8	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.4	3.2	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.4	1.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.3	3.0	GO:0004383	guanylate cyclase activity(GO:0004383)
0.3	1.0	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.3	2.3	GO:0033691	sialic acid binding(GO:0033691)
0.3	4.3	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3	1.0	GO:0018598	mono-butyltin dioxygenase activity(GO:0018586) tri-n-butyltin dioxygenase activity(GO:0018588) di-n-butyltin dioxygenase activity(GO:0018589) methylsilanetriol hydroxylase activity(GO:0018590) methyl tertiary butyl ether 3-monooxygenase activity(GO:0018591) 4-nitrocatechol 4-monooxygenase activity(GO:0018592) 4-chlorophenoxyacetate monooxygenase activity(GO:0018593) tert-butanol 2-monooxygenase activity(GO:0018594) alpha-pinene monooxygenase activity(GO:0018595) dimethylsilanediol hydroxylase activity(GO:0018596) ammonia monooxygenase activity(GO:0018597) hydroxymethylsilanetriol oxidase activity(GO:0018598) 2-hydroxyisobutyrate 3-monooxygenase activity(GO:0018599) alpha-pinene dehydrogenase activity(GO:0018600) bisphenol A hydroxylase B activity(GO:0034559) 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity(GO:0034562) 9-fluorenone-3,4-dioxygenase activity(GO:0034786) anthracene 9,10-dioxygenase activity(GO:0034816) 2-(methylthio)benzothiazole monooxygenase activity(GO:0034857) 2-hydroxybenzothiazole monooxygenase activity(GO:0034858) benzothiazole monooxygenase activity(GO:0034859) 2,6-dihydroxybenzothiazole monooxygenase activity(GO:0034862) pinacolone 5-monooxygenase activity(GO:0034870) thioacetamide S-oxygenase activity(GO:0034873) thioacetamide S-oxide S-oxygenase activity(GO:0034874) endosulfan monooxygenase I activity(GO:0034888) N-nitrodimethylamine hydroxylase activity(GO:0034893) 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity(GO:0034897) endosulfan ether monooxygenase activity(GO:0034903) pyrene 4,5-monooxygenase activity(GO:0034925) pyrene 1,2-monooxygenase activity(GO:0034927) 1-hydroxypyrene 6,7-monooxygenase activity(GO:0034928) 1-hydroxypyrene 7,8-monooxygenase activity(GO:0034929) phenylboronic acid monooxygenase activity(GO:0034950) spheroidene monooxygenase activity(GO:0043823)
0.3	2.3	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.3	0.6	GO:0004065	arylsulfatase activity(GO:0004065)
0.3	4.4	GO:0022842	leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.3	3.4	GO:0001671	ATPase activator activity(GO:0001671)
0.3	3.4	GO:0031404	chloride ion binding(GO:0031404)
0.3	0.9	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.3	2.1	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.3	0.9	GO:0004731	purine-nucleoside phosphorylase activity(GO:0004731)
0.3	6.3	GO:0005540	hyaluronic acid binding(GO:0005540)
0.3	1.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.3	2.0	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.3	1.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.3	1.7	GO:0016443	bidentate ribonuclease III activity(GO:0016443)
0.3	1.7	GO:0070097	delta-catenin binding(GO:0070097)
0.3	2.7	GO:0051378	serotonin binding(GO:0051378)
0.3	0.3	GO:0050693	LBD domain binding(GO:0050693)
0.3	1.0	GO:0004031	aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.3	9.3	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.2	1.2	GO:1990254	keratin filament binding(GO:1990254)
0.2	0.7	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2	4.5	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2	1.2	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)
0.2	5.2	GO:0004119	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.2	0.7	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.2	1.5	GO:0070990	snRNP binding(GO:0070990)
0.2	2.2	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.2	1.1	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2	2.7	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.2	0.6	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.2	0.8	GO:0005166	neurotrophin p75 receptor binding(GO:0005166)
0.2	0.6	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.2	0.8	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.2	1.8	GO:0070182	DNA polymerase binding(GO:0070182)
0.2	0.6	GO:0019862	IgA binding(GO:0019862)
0.2	1.1	GO:0004952	dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588) dopamine neurotransmitter receptor activity(GO:0004952)
0.2	0.9	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.2	0.6	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.2	2.6	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.2	1.7	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2	1.3	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.2	0.7	GO:0030628	pre-mRNA 3'-splice site binding(GO:0030628)
0.2	0.9	GO:0046790	virion binding(GO:0046790)
0.2	9.8	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2	0.9	GO:0031420	alkali metal ion binding(GO:0031420)
0.2	14.5	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.2	0.5	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.2	0.5	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.2	0.7	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
0.2	0.5	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2	0.5	GO:0089720	caspase binding(GO:0089720)
0.2	1.9	GO:0031005	filamin binding(GO:0031005)
0.1	1.5	GO:0004707	MAP kinase activity(GO:0004707)
0.1	1.5	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1	0.6	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1	0.7	GO:0036310	annealing helicase activity(GO:0036310)
0.1	0.7	GO:0071723	lipopeptide binding(GO:0071723)
0.1	1.1	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.1	0.4	GO:0008158	hedgehog receptor activity(GO:0008158)
0.1	0.3	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
0.1	0.8	GO:0015180	L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.1	4.2	GO:0033038	bitter taste receptor activity(GO:0033038)
0.1	1.0	GO:0008318	protein prenyltransferase activity(GO:0008318)
0.1	0.1	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.1	1.2	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.1	0.9	GO:0102337	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1	0.6	GO:0004111	creatine kinase activity(GO:0004111)
0.1	1.5	GO:0019841	retinol binding(GO:0019841)
0.1	0.1	GO:0001601	peptide YY receptor activity(GO:0001601)
0.1	0.2	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.1	1.6	GO:0070628	proteasome binding(GO:0070628)
0.1	0.2	GO:0035870	dITP diphosphatase activity(GO:0035870)
0.1	0.7	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.1	2.7	GO:0005109	frizzled binding(GO:0005109)
0.1	0.1	GO:0033142	progesterone receptor binding(GO:0033142)
0.1	0.1	GO:0019958	C-X-C chemokine binding(GO:0019958)
0.1	0.3	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	1.5	GO:0003785	actin monomer binding(GO:0003785)
0.1	0.8	GO:0031386	protein tag(GO:0031386)
0.1	0.3	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.1	1.4	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.1	0.2	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1	0.3	GO:0097001	ceramide binding(GO:0097001)
0.1	0.3	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1	0.4	GO:0008131	primary amine oxidase activity(GO:0008131)
0.1	0.2	GO:0004667	prostaglandin-D synthase activity(GO:0004667)
0.1	0.2	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.1	0.7	GO:0001134	transcription factor activity, transcription factor recruiting(GO:0001134)
0.1	0.2	GO:0071532	ankyrin repeat binding(GO:0071532)
0.1	0.3	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1	0.4	GO:0032184	SUMO polymer binding(GO:0032184)
0.1	0.3	GO:0004558	alpha-1,4-glucosidase activity(GO:0004558)
0.1	0.2	GO:0019002	GMP binding(GO:0019002)
0.1	0.3	GO:0005113	patched binding(GO:0005113)
0.1	0.3	GO:0019992	diacylglycerol binding(GO:0019992)
0.1	0.3	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.1	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.1	GO:0004946	bombesin receptor activity(GO:0004946)
0.0	0.1	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
0.0	0.1	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	16.9	GO:0005549	odorant binding(GO:0005549)
0.0	0.2	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0034584	piRNA binding(GO:0034584)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0004556	alpha-amylase activity(GO:0004556)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0004083	bisphosphoglycerate 2-phosphatase activity(GO:0004083)
0.0	0.1	GO:0004942	anaphylatoxin receptor activity(GO:0004942)
0.0	0.2	GO:0005223	intracellular cGMP activated cation channel activity(GO:0005223)
0.0	0.4	GO:0001594	trace-amine receptor activity(GO:0001594)
0.0	0.0	GO:0015556	C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0	0.3	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.0	0.0	GO:0030519	snoRNP binding(GO:0030519)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0102345	3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0	0.5	GO:0042169	SH2 domain binding(GO:0042169)
0.0	0.0	GO:0001016	RNA polymerase III regulatory region DNA binding(GO:0001016)
0.0	0.0	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.0	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.0	GO:0008271	secondary active sulfate transmembrane transporter activity(GO:0008271)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.7	27.5	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
1.3	24.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
1.0	30.9	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.8	1.6	PID NECTIN PATHWAY	Nectin adhesion pathway
0.8	10.6	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.6	19.7	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.6	6.6	PID ALK2 PATHWAY	ALK2 signaling events
0.5	1.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.5	11.9	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.4	15.0	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.4	4.8	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.4	5.8	PID S1P S1P2 PATHWAY	S1P2 pathway
0.4	10.4	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.4	2.2	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.3	5.9	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.3	6.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.3	12.2	PID SHP2 PATHWAY	SHP2 signaling
0.3	0.3	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.3	0.3	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.3	0.5	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.3	4.9	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.2	2.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.2	1.6	ST G ALPHA S PATHWAY	G alpha s Pathway
0.2	0.5	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.2	0.9	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2	2.0	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.2	1.2	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.2	2.7	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2	1.5	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	2.6	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	1.7	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	0.2	PID REELIN PATHWAY	Reelin signaling pathway
0.1	0.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	0.4	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	6.4	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	3.8	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	0.8	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.1	0.2	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.1	1.9	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	2.0	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	0.1	SIG CHEMOTAXIS	Genes related to chemotaxis
0.1	0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	0.7	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1	0.7	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.1	0.2	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.0	1.1	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.2	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	1.0	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	0.1	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	0.6	PID CDC42 PATHWAY	CDC42 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.7	29.7	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
2.4	26.2	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
2.3	2.3	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
1.8	18.5	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
1.7	55.3	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
1.6	18.0	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
1.6	11.3	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
1.6	4.8	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
1.4	30.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
1.4	10.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
1.3	1.3	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
1.3	9.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
1.3	15.6	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
1.2	19.6	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
1.2	17.6	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.1	3.3	REACTOME SIGNALING BY ILS	Genes involved in Signaling by Interleukins
1.1	20.6	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
1.0	1.9	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.9	1.8	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.9	10.8	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.9	11.5	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.9	15.9	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.8	6.7	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.8	8.4	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.8	7.4	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.8	8.0	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.8	5.4	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.8	11.3	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.7	15.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.7	10.7	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.7	5.6	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.7	1.4	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.7	9.3	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.6	7.9	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.6	23.5	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.5	10.1	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.5	5.3	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.5	11.6	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.5	6.0	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.5	1.5	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.5	15.8	REACTOME RNA POL III TRANSCRIPTION	Genes involved in RNA Polymerase III Transcription
0.5	3.7	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.5	6.4	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.4	2.2	REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	Genes involved in GRB2 events in ERBB2 signaling
0.4	3.9	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.4	5.5	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.4	5.6	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.4	9.0	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.4	3.1	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.4	7.3	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.4	4.6	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.3	2.4	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.3	3.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.3	4.0	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.3	2.6	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.3	3.9	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.3	4.9	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3	6.4	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.3	3.4	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.3	1.8	REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	Genes involved in Glucagon signaling in metabolic regulation
0.3	3.7	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.2	3.8	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.2	0.2	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.2	7.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.2	0.7	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.2	1.9	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.2	0.2	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2	0.2	REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	Genes involved in NCAM signaling for neurite out-growth
0.1	1.3	REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1	0.8	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	6.2	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	0.5	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.1	0.1	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.1	1.2	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.1	4.1	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.1	0.4	REACTOME PEPTIDE HORMONE BIOSYNTHESIS	Genes involved in Peptide hormone biosynthesis
0.1	0.4	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.1	0.8	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.1	0.1	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1	0.2	REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.1	0.3	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1	0.5	REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX	Genes involved in TRAF6 mediated induction of TAK1 complex
0.1	0.7	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.5	REACTOME BOTULINUM NEUROTOXICITY	Genes involved in Botulinum neurotoxicity
0.0	0.6	REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	Genes involved in Acetylcholine Binding And Downstream Events
0.0	0.3	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.0	0.4	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.0	0.4	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.0	0.4	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.4	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	0.2	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors

Results for Isl1

Z-value: 10.05

Motif logo

Transcription factors associated with Isl1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Isl1 motif across conditions

Conditions sorted by the z-value of the Isl1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Isl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: