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ENCODE: ATAC-seq of different tissues during embryonic development

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Results for Rest

Z-value: 3.15

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Transcription factors associated with Rest

Gene Symbol	Gene ID	Gene Info
Rest Ensembl NCBI MGI UniProt	ENSMUSG00000029249.9	RE1-silencing transcription factor

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr5_77265440_77265620	Rest	39	0.963579	-0.39	3.4e-03	Click!
chr5_77265690_77265850	Rest	279	0.865451	-0.33	1.3e-02	Click!
chr5_77265868_77266520	Rest	2	0.965657	-0.32	1.6e-02	Click!
chr5_77265136_77265398	Rest	224	0.898492	-0.32	1.9e-02	Click!

Activity of the Rest motif across conditions

Conditions sorted by the z-value of the Rest motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_80802510_80803270	23.93	Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	55	0.98
chr7_44593726_44594565	22.12	Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	150	0.87
chr2_153032073_153032585	21.82	Xkr7	X-linked Kx blood group related 7	477	0.72
chr19_42255864_42256313	21.41	Golga7b	golgi autoantigen, golgin subfamily a, 7B	349	0.83
chr17_91092798_91092976	19.28	Nrxn1	neurexin I	84	0.96
chr6_127766930_127768435	19.28	Gm42738	predicted gene 42738	140	0.91
chr8_55940572_55940786	18.77	Glra3	glycine receptor, alpha 3 subunit	146	0.96
chr9_27308175_27308373	18.22	Igsf9b	immunoglobulin superfamily, member 9B	9046	0.2
chr7_51621534_51622183	17.99	Slc17a6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	148	0.96
chr13_78171338_78171906	17.70	3110006O06Rik	RIKEN cDNA 3110006O06 gene	8	0.97
chr6_121472994_121473484	17.34	Iqsec3	IQ motif and Sec7 domain 3	384	0.87
chr1_74858050_74858726	17.27	Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	3454	0.13
chr7_63444022_63445137	16.29	4930554H23Rik	RIKEN cDNA 4930554H23 gene	50	0.67
chr5_116591443_116591692	16.25	Srrm4	serine/arginine repetitive matrix 4	250	0.92
chr1_34579595_34579789	15.99	1700101I19Rik	RIKEN cDNA 1700101I19 gene	19	0.5
chr9_40269600_40269831	15.74	Scn3b	sodium channel, voltage-gated, type III, beta	28	0.96
chr11_41999507_41999953	15.69	Gabrg2	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	626	0.81
chr6_134888153_134888812	15.61	Gpr19	G protein-coupled receptor 19	650	0.56
chr2_181764694_181764868	15.61	Myt1	myelin transcription factor 1	1449	0.33
chr3_94477953_94478530	15.47	Celf3	CUGBP, Elav-like family member 3	54	0.93
chr6_45059215_45059397	15.14	Cntnap2	contactin associated protein-like 2	51	0.97
chr6_39871998_39872940	15.00	Gm26833	predicted gene, 26833	498	0.51
chr2_24761902_24762681	14.84	Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	756	0.65
chr12_102554973_102555665	14.52	Chga	chromogranin A	333	0.86
chr1_5022831_5023607	14.45	Rgs20	regulator of G-protein signaling 20	3680	0.21
chr18_25677554_25677705	14.42	0710001A04Rik	RIKEN cDNA 0710001A04 gene	36141	0.19
chr2_25319011_25319403	14.41	Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	20	0.93
chr4_15881199_15881390	14.30	Calb1	calbindin 1	28	0.97
chr3_114903945_114904471	14.29	Olfm3	olfactomedin 3	130	0.98
chr15_76522202_76522451	14.20	Scrt1	scratch family zinc finger 1	173	0.86
chr1_3670747_3671221	13.94	Xkr4	X-linked Kx blood group related 4	514	0.76
chr1_154723575_154723741	13.86	Cacna1e	calcium channel, voltage-dependent, R type, alpha 1E subunit	2262	0.45
chr17_69968795_69969671	13.70	Dlgap1	DLG associated protein 1	13	0.98
chr6_96420593_96420744	13.48	Gm22971	predicted gene, 22971	48863	0.19
chr1_175492016_175492222	13.40	Rgs7	regulator of G protein signaling 7	157	0.97
chr6_91839426_91839831	13.24	Grip2	glutamate receptor interacting protein 2	12378	0.15
chr12_102949723_102950089	12.89	Unc79	unc-79 homolog	352	0.85
chr11_71389717_71389968	12.86	Gm16013	predicted gene 16013	46338	0.14
chr1_159524066_159524301	12.44	Tnr	tenascin R	342	0.91
chr5_37243556_37243987	12.37	Crmp1	collapsin response mediator protein 1	1037	0.54
chr14_24762851_24763029	12.22	Gm47906	predicted gene, 47906	70695	0.11
chr18_64266557_64266910	12.07	St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	75	0.97
chr6_88977086_88977237	11.91	4933427D06Rik	RIKEN cDNA 4933427D06 gene	26478	0.14
chr5_144542770_144543233	11.70	Nptx2	neuronal pentraxin 2	2901	0.34
chr19_22139224_22139425	11.52	Trpm3	transient receptor potential cation channel, subfamily M, member 3	207	0.96
chr2_136714004_136714407	11.47	Snap25	synaptosomal-associated protein 25	727	0.7
chr1_6767739_6768048	11.30	St18	suppression of tumorigenicity 18	30318	0.2
chr12_112511097_112511384	11.16	Tmem179	transmembrane protein 179	68	0.97
chr1_84695758_84696417	11.00	Dner	delta/notch-like EGF repeat containing	68	0.74
chr9_108825836_108826138	10.89	Celsr3	cadherin, EGF LAG seven-pass G-type receptor 3	333	0.56
chr6_8957526_8957759	10.79	Nxph1	neurexophilin 1	7966	0.32
chr10_11081573_11081953	10.69	Grm1	glutamate receptor, metabotropic 1	487	0.84
chr8_86961304_86961514	10.60	Gm24781	predicted gene, 24781	4210	0.19
chr11_35798967_35799118	10.39	Fbll1	fibrillarin-like 1	158	0.94
chr12_108327889_108328514	10.36	4930478K11Rik	RIKEN cDNA 4930478K11 gene	171	0.94
chr7_81493315_81493555	10.32	Ap3b2	adaptor-related protein complex 3, beta 2 subunit	244	0.86
chr19_6502524_6502901	10.23	Nrxn2	neurexin II	4877	0.13
chr9_89909481_89910044	10.22	Rasgrf1	RAS protein-specific guanine nucleotide-releasing factor 1	146	0.97
chr14_55491210_55491794	10.19	Carmil3	capping protein regulator and myosin 1 linker 3	329	0.75
chr14_79769587_79769997	10.18	Gm9748	predicted gene 9748	116	0.94
chrX_20920853_20921192	9.82	Syn1	synapsin I	18	0.96
chr7_4996684_4996835	9.70	Zfp579	zinc finger protein 579	601	0.45
chr7_57592252_57592447	9.55	Gabrb3	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	819	0.67
chr10_128668794_128669181	9.51	Ikzf4	IKAROS family zinc finger 4	371	0.68
chr7_27653689_27654081	9.41	Ttc9b	tetratricopeptide repeat domain 9B	30	0.95
chr2_181313827_181314345	9.34	Stmn3	stathmin-like 3	414	0.71
chr3_103573867_103574061	9.33	Syt6	synaptotagmin VI	1267	0.43
chr7_138084080_138084232	9.26	Gm25798	predicted gene, 25798	17383	0.23
chr12_70347235_70347564	9.23	Trim9	tripartite motif-containing 9	49	0.51
chr16_75447178_75447385	9.09	Gm49678	predicted gene, 49678	12	0.98
chr6_51162533_51162684	8.96	Mir148a	microRNA 148a	107302	0.06
chr13_28859970_28860121	8.95	Gm11362	predicted gene 11362	23170	0.15
chr4_101550249_101551121	8.89	Dnajc6	DnaJ heat shock protein family (Hsp40) member C6	91	0.98
chr3_89764091_89764749	8.86	Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	188	0.9
chr12_86983589_86983761	8.66	Zdhhc22	zinc finger, DHHC-type containing 22	160	0.94
chr17_6321401_6321993	8.64	AC183097.1	transmembrane protein 181 (TMEM181) pseudogene	39	0.96
chr18_31446823_31447492	8.64	Syt4	synaptotagmin IV	249	0.91
chr2_180894434_180894698	8.63	Gm27032	predicted gene, 27032	461	0.44
chr2_132781417_132782079	8.57	Chgb	chromogranin B	470	0.75
chr10_6788437_6788919	8.57	Oprm1	opioid receptor, mu 1	16	0.98
chr17_6490637_6490798	8.56	Tmem181b-ps	transmembrane protein 181B, pseudogene	23695	0.14
chr14_12529953_12530619	8.55	Cadps	Ca2+-dependent secretion activator	11672	0.23
chr11_55607825_55607993	8.51	Glra1	glycine receptor, alpha 1 subunit	88	0.97
chr1_127496867_127497034	8.49	Tmem163	transmembrane protein 163	3394	0.32
chr2_125135896_125136068	8.48	Ctxn2	cortexin 2	651	0.57
chr5_149488554_149488977	8.29	Gm2566	predicted gene 2566	14287	0.12
chr13_72419489_72419940	8.27	Rpl9-ps4	ribosomal protein L9, pseudogene 4	35626	0.14
chr2_109675796_109676156	8.21	Bdnf	brain derived neurotrophic factor	79	0.91
chr17_28575576_28575776	8.15	Lhfpl5	lipoma HMGIC fusion partner-like 5	23	0.95
chr2_54085816_54085989	8.08	Rprm	reprimo, TP53 dependent G2 arrest mediator candidate	350	0.91
chr1_72536926_72537338	8.06	Marchf4	membrane associated ring-CH-type finger 4	202	0.95
chr18_38470489_38470640	8.04	Gm50349	predicted gene, 50349	10739	0.16
chr2_155775637_155775962	8.00	Mmp24	matrix metallopeptidase 24	457	0.71
chr13_99900591_99900742	7.97	Cartpt	CART prepropeptide	25	0.98
chr7_44335720_44335895	7.94	Shank1	SH3 and multiple ankyrin repeat domains 1	209	0.82
chr7_99468487_99468808	7.90	Klhl35	kelch-like 35	316	0.81
chr5_36836058_36836209	7.64	Man2b2	mannosidase 2, alpha B2	5480	0.16
chr2_79454217_79454420	7.47	Neurod1	neurogenic differentiation 1	2433	0.28
chr18_25668110_25668336	7.46	0710001A04Rik	RIKEN cDNA 0710001A04 gene	45547	0.16
chr14_32321782_32322361	7.36	Ogdhl	oxoglutarate dehydrogenase-like	52	0.96
chr8_85071597_85072595	7.36	Dhps	deoxyhypusine synthase	205	0.79
chr8_22974881_22975531	7.34	Ank1	ankyrin 1, erythroid	70	0.97
chr8_105693659_105694315	7.26	Carmil2	capping protein regulator and myosin 1 linker 2	1077	0.28
chr4_153482260_153482820	7.26	Ajap1	adherens junction associated protein 1	271	0.96
chr5_113716549_113717093	7.25	1700069L16Rik	RIKEN cDNA 1700069L16 gene	7928	0.13
chr5_27841715_27841929	7.19	Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	327	0.84
chr5_121009485_121009636	7.16	Rph3a	rabphilin 3A	22	0.97
chr12_50698624_50698776	7.10	Prkd1	protein kinase D1	49602	0.16
chr2_92401329_92401524	7.02	Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	163	0.91
chr12_88709368_88709542	6.96	Nrxn3	neurexin III	13421	0.2
chr9_40873778_40874068	6.96	Bsx	brain specific homeobox	204	0.91
chr5_33438220_33438564	6.92	Gm43851	predicted gene 43851	928	0.54
chr6_120492980_120494328	6.87	Tmem121b	transmembrane protein 121B	153	0.93
chr16_37384311_37385444	6.83	Stxbp5l	syntaxin binding protein 5-like	46	0.98
chr14_66909816_66910393	6.80	Pnma2	paraneoplastic antigen MA2	1066	0.45
chr4_20777672_20778960	6.60	Nkain3	Na+/K+ transporting ATPase interacting 3	251	0.96
chr4_148286711_148286976	6.59	Disp3	dispatched RND transporter family member 3	1122	0.47
chr3_34503986_34504142	6.36	Gm29135	predicted gene 29135	21857	0.16
chrX_60547993_60548358	6.32	Gm715	predicted gene 715	156	0.94
chr1_12864440_12864591	6.28	Sulf1	sulfatase 1	21724	0.22
chr13_69987558_69987813	6.22	Gm47655	predicted gene, 47655	19929	0.15
chr19_10403218_10403369	6.10	Syt7	synaptotagmin VII	725	0.62
chr18_61737084_61737369	5.88	1500015A07Rik	RIKEN cDNA 1500015A07 gene	2869	0.18
chr15_27797878_27798436	5.83	Trio	triple functional domain (PTPRF interacting)	9519	0.23
chr13_54757718_54759007	5.82	Sncb	synuclein, beta	4705	0.13
chr7_30521040_30521191	5.64	Arhgap33os	Rho GTPase activating protein 33, opposite strand	5416	0.06
chr17_72603238_72603477	5.63	Alk	anaplastic lymphoma kinase	470	0.87
chr12_103532390_103533235	5.56	Ppp4r4	protein phosphatase 4, regulatory subunit 4	242	0.91
chr2_180889406_180890514	5.37	Gm14342	predicted gene 14342	300	0.8
chr2_27142408_27142596	5.32	Fam163b	family with sequence similarity 163, member B	11	0.96
chr1_167661178_167661500	5.29	Lmx1a	LIM homeobox transcription factor 1 alpha	27898	0.21
chr9_57467552_57468361	5.26	Scamp5	secretory carrier membrane protein 5	39	0.95
chr11_117873034_117873590	5.23	Tha1	threonine aldolase 1	147	0.91
chr2_172042232_172042427	5.13	Cbln4	cerebellin 4 precursor protein	1137	0.44
chr6_17171822_17172003	5.13	Gm4876	predicted gene 4876	79	0.98
chr2_157456818_157457434	5.07	Src	Rous sarcoma oncogene	41	0.98
chr11_3774636_3774833	5.00	Osbp2	oxysterol binding protein 2	2	0.97
chr2_22621544_22622307	5.00	Gad2	glutamic acid decarboxylase 2	280	0.87
chr1_81076845_81077078	4.87	Nyap2	neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2	11	0.99
chr9_58060934_58061155	4.84	Stra6	stimulated by retinoic acid gene 6	2744	0.19
chr17_6256524_6257400	4.67	Tmem181a	transmembrane protein 181A	12	0.97
chr12_116486150_116486505	4.59	Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	494	0.73
chr10_93261321_93261653	4.58	Cdk17	cyclin-dependent kinase 17	22464	0.16
chr5_126651491_126651642	4.48	1700081B01Rik	RIKEN cDNA 1700081B01 gene	55348	0.14
chr4_99194060_99194516	4.39	Atg4c	autophagy related 4C, cysteine peptidase	141	0.96
chr2_180891097_180891925	4.37	Gm14342	predicted gene 14342	1851	0.17
chr15_11905447_11905672	4.37	Npr3	natriuretic peptide receptor 3	80	0.94
chr7_29210966_29212124	4.18	Catsperg1	cation channel sperm associated auxiliary subunit gamma 1	50	0.94
chr17_88494086_88494388	4.14	Ppp1r21	protein phosphatase 1, regulatory subunit 21	35881	0.13
chr12_36317042_36317510	4.02	Sostdc1	sclerostin domain containing 1	3137	0.2
chr15_88469626_88469777	3.97	Zdhhc25	zinc finger, DHHC domain containing 25	130601	0.05
chr3_102469857_102470008	3.97	Ngf	nerve growth factor	4	0.98
chr9_61573670_61573999	3.95	Gm34424	predicted gene, 34424	40419	0.18
chr9_35559021_35559223	3.95	Pus3	pseudouridine synthase 3	338	0.61
chr9_104569499_104569681	3.94	Cpne4	copine IV	107	0.98
chrX_8205746_8205897	3.90	Porcn	porcupine O-acyltransferase	670	0.56
chr8_4140155_4140370	3.86	Cd209g	CD209g antigen	5610	0.13
chr14_55109076_55109960	3.74	Jph4	junctophilin 4	1040	0.3
chr2_91921263_91921470	3.73	Gm10805	predicted gene 10805	438	0.73
chr4_155018732_155018883	3.68	Plch2	phospholipase C, eta 2	621	0.64
chr11_98329952_98330103	3.67	Neurod2	neurogenic differentiation 2	379	0.73
chr1_151890040_151890576	3.64	Gm28610	predicted gene 28610	14889	0.19
chr10_121309994_121311399	3.62	Tbc1d30	TBC1 domain family, member 30	493	0.76
chr16_18128648_18128851	3.62	Rtn4r	reticulon 4 receptor	1107	0.39
chr3_19694240_19694727	3.62	Crh	corticotropin releasing hormone	913	0.51
chr4_63221600_63221817	3.61	Col27a1	collagen, type XXVII, alpha 1	6273	0.18
chr4_91374952_91375142	3.58	Elavl2	ELAV like RNA binding protein 1	1260	0.39
chr14_93891085_93891287	3.51	Pcdh9	protocadherin 9	507	0.87
chr17_45536361_45536512	3.41	Tcte1	t-complex-associated testis expressed 1	3383	0.12
chr18_25752867_25753034	3.37	Celf4	CUGBP, Elav-like family member 4	258	0.94
chr3_28264071_28264435	3.27	Tnik	TRAF2 and NCK interacting kinase	610	0.76
chr9_32292943_32293094	3.22	Arhgap32	Rho GTPase activating protein 32	47854	0.11
chr7_84085117_84085268	3.20	Cemip	cell migration inducing protein, hyaluronan binding	1310	0.46
chr14_63681627_63681805	3.17	Xkr6	X-linked Kx blood group related 6	22559	0.18
chr4_128693249_128693510	3.16	Phc2	polyhomeotic 2	4584	0.22
chr2_127521161_127522051	3.15	Kcnip3	Kv channel interacting protein 3, calsenilin	236	0.88
chr7_93006784_93007170	3.14	Gm26862	predicted gene, 26862	5	0.98
chr3_158310492_158310686	3.07	Gm43486	predicted gene 43486	16175	0.22
chr14_25512879_25513080	3.03	Zmiz1	zinc finger, MIZ-type containing 1	10324	0.15
chr1_85179620_85180245	2.97	Gm6264	predicted gene 6264	19069	0.09
chr1_160286463_160286633	2.95	Rabgap1l	RAB GTPase activating protein 1-like	790	0.54
chr10_90828740_90829725	2.92	Anks1b	ankyrin repeat and sterile alpha motif domain containing 1B	111	0.96
chr1_99772225_99772455	2.89	Cntnap5b	contactin associated protein-like 5B	425	0.87
chr10_39498773_39498924	2.87	Fyn	Fyn proto-oncogene	12891	0.21
chr3_84190792_84190962	2.87	Trim2	tripartite motif-containing 2	354	0.88
chr1_56971032_56971183	2.82	9130024F11Rik	RIKEN cDNA 9130024F11 gene	305	0.76
chr15_10981377_10981882	2.79	Amacr	alpha-methylacyl-CoA racemase	127	0.95
chr10_20459280_20459454	2.77	Pde7b	phosphodiesterase 7B	12476	0.21
chr12_112798336_112798578	2.76	Ahnak2	AHNAK nucleoprotein 2	4200	0.12
chr19_44671708_44671902	2.76	Gm26644	predicted gene, 26644	23470	0.15
chr13_78176356_78176507	2.75	3110006O06Rik	RIKEN cDNA 3110006O06 gene	4801	0.15
chr2_149768696_149768879	2.75	Gm14130	predicted gene 14130	25612	0.17
chr1_188118140_188118499	2.72	Gm38315	predicted gene, 38315	42388	0.18
chr16_5146393_5147047	2.70	Sec14l5	SEC14-like lipid binding 5	389	0.79
chr15_74076109_74076632	2.67	Gm7935	predicted pseudogene 7935	5141	0.24
chr5_93127800_93128070	2.61	Septin11	septin 11	20568	0.11
chr5_24496740_24497147	2.58	Agap3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	16771	0.08
chr5_120424134_120424285	2.56	Lhx5	LIM homeobox protein 5	7490	0.14
chr10_94991252_94991474	2.54	Gm48867	predicted gene, 48867	8079	0.22
chr13_54371366_54372279	2.53	Cplx2	complexin 2	473	0.79

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Rest

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
6.2	18.5	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
6.0	18.0	GO:0097112	gamma-aminobutyric acid receptor clustering(GO:0097112)
5.1	15.2	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
4.7	14.2	GO:0021586	pons maturation(GO:0021586)
4.0	12.1	GO:1900738	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
3.9	11.6	GO:0097503	sialylation(GO:0097503)
3.8	11.3	GO:0048677	axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
3.3	9.8	GO:0018364	peptidyl-glutamine methylation(GO:0018364)
2.8	8.5	GO:0031635	adenylate cyclase-inhibiting opioid receptor signaling pathway(GO:0031635)
2.7	13.5	GO:0070842	aggresome assembly(GO:0070842)
2.7	8.0	GO:0060084	synaptic transmission involved in micturition(GO:0060084)
2.5	12.5	GO:0031339	negative regulation of vesicle fusion(GO:0031339)
2.4	9.7	GO:0070093	negative regulation of glucagon secretion(GO:0070093)
2.4	19.1	GO:0071420	cellular response to histamine(GO:0071420)
2.1	15.0	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
2.0	24.1	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
2.0	5.9	GO:0060478	acrosomal vesicle exocytosis(GO:0060478)
1.9	7.4	GO:0007412	axon target recognition(GO:0007412)
1.8	7.3	GO:0046959	habituation(GO:0046959)
1.7	6.7	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
1.6	6.4	GO:0007258	JUN phosphorylation(GO:0007258)
1.6	4.7	GO:1904180	negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
1.5	6.1	GO:0036515	serotonergic neuron axon guidance(GO:0036515)
1.5	5.8	GO:0006598	polyamine catabolic process(GO:0006598)
1.4	8.3	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
1.3	5.3	GO:0006566	threonine metabolic process(GO:0006566)
1.3	5.3	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
1.3	11.5	GO:0048149	behavioral response to ethanol(GO:0048149)
1.2	1.2	GO:0090493	catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
1.2	3.6	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
1.2	8.3	GO:0007220	Notch receptor processing(GO:0007220)
1.2	2.4	GO:0060112	generation of ovulation cycle rhythm(GO:0060112)
1.1	9.8	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
1.1	4.3	GO:0006538	glutamate catabolic process(GO:0006538)
1.0	12.6	GO:0007614	short-term memory(GO:0007614)
1.0	4.2	GO:0051697	protein delipidation(GO:0051697)
1.0	6.3	GO:0090273	regulation of somatostatin secretion(GO:0090273)
1.0	5.2	GO:1902866	regulation of retina development in camera-type eye(GO:1902866)
1.0	17.3	GO:0001504	neurotransmitter uptake(GO:0001504)
1.0	14.9	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.9	3.8	GO:0070092	regulation of glucagon secretion(GO:0070092)
0.9	8.4	GO:0071257	cellular response to electrical stimulus(GO:0071257)
0.9	29.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.9	9.5	GO:0033574	response to testosterone(GO:0033574)
0.8	2.3	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.8	1.5	GO:2000474	regulation of opioid receptor signaling pathway(GO:2000474)
0.7	1.5	GO:1900020	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.7	6.5	GO:0060539	diaphragm development(GO:0060539)
0.7	10.0	GO:0016082	synaptic vesicle priming(GO:0016082)
0.7	5.4	GO:0097151	positive regulation of inhibitory postsynaptic potential(GO:0097151)
0.7	6.0	GO:0044331	cell-cell adhesion mediated by cadherin(GO:0044331)
0.7	8.7	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
0.6	21.1	GO:0046928	regulation of neurotransmitter secretion(GO:0046928)
0.6	9.0	GO:0099517	anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.6	4.2	GO:0002158	osteoclast proliferation(GO:0002158)
0.6	7.6	GO:0060088	auditory receptor cell stereocilium organization(GO:0060088)
0.6	6.3	GO:0060056	mammary gland involution(GO:0060056)
0.6	1.1	GO:0089700	protein kinase D signaling(GO:0089700)
0.6	1.7	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
0.5	2.0	GO:2000535	entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.5	2.5	GO:0007256	activation of JNKK activity(GO:0007256)
0.5	2.3	GO:2000675	negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.5	22.2	GO:0099643	neurotransmitter secretion(GO:0007269) presynaptic process involved in chemical synaptic transmission(GO:0099531) signal release from synapse(GO:0099643)
0.5	1.8	GO:0023041	neuronal signal transduction(GO:0023041)
0.4	4.8	GO:0045956	positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.4	1.3	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.4	3.8	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.4	1.3	GO:0086064	cell communication by electrical coupling involved in cardiac conduction(GO:0086064)
0.4	3.2	GO:0090244	Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.4	12.0	GO:2001222	regulation of neuron migration(GO:2001222)
0.4	1.2	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.4	2.3	GO:0031119	tRNA pseudouridine synthesis(GO:0031119)
0.4	13.9	GO:0042462	eye photoreceptor cell development(GO:0042462)
0.4	2.7	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.4	3.3	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.3	7.2	GO:0072661	protein targeting to plasma membrane(GO:0072661)
0.3	2.5	GO:0090177	establishment of planar polarity involved in neural tube closure(GO:0090177)
0.3	0.3	GO:0071205	protein localization to juxtaparanode region of axon(GO:0071205)
0.3	2.8	GO:0097120	receptor localization to synapse(GO:0097120)
0.3	2.1	GO:0014824	artery smooth muscle contraction(GO:0014824)
0.3	0.9	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.3	1.1	GO:0016139	glycoside catabolic process(GO:0016139)
0.3	5.1	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.3	1.3	GO:0090383	phagosome acidification(GO:0090383)
0.2	1.0	GO:0018214	protein carboxylation(GO:0018214)
0.2	0.7	GO:0015747	urate transport(GO:0015747)
0.2	0.7	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.2	5.1	GO:0018345	protein palmitoylation(GO:0018345)
0.2	6.1	GO:0006099	tricarboxylic acid cycle(GO:0006099)
0.2	0.6	GO:0050968	detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.2	0.2	GO:0048022	negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.2	0.6	GO:0090271	positive regulation of fibroblast growth factor production(GO:0090271)
0.2	0.2	GO:0097374	sensory neuron axon guidance(GO:0097374)
0.2	0.8	GO:2000546	positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.2	1.9	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.2	0.4	GO:0042706	eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.2	6.9	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.2	0.4	GO:0003284	septum primum development(GO:0003284) atrial septum primum morphogenesis(GO:0003289)
0.2	0.9	GO:1904948	midbrain dopaminergic neuron differentiation(GO:1904948)
0.2	1.4	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
0.2	0.3	GO:0060221	retinal rod cell differentiation(GO:0060221)
0.2	0.5	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.2	0.5	GO:1904706	negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.2	0.5	GO:0006562	proline catabolic process(GO:0006562)
0.2	0.5	GO:0030327	prenylated protein catabolic process(GO:0030327)
0.2	0.7	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
0.2	0.6	GO:1900194	negative regulation of oocyte maturation(GO:1900194)
0.2	0.5	GO:0045199	maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.1	0.7	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.1	4.8	GO:0046676	negative regulation of insulin secretion(GO:0046676)
0.1	5.9	GO:0019933	cAMP-mediated signaling(GO:0019933)
0.1	2.3	GO:0048266	behavioral response to pain(GO:0048266)
0.1	9.9	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1	0.4	GO:0060214	endocardium formation(GO:0060214)
0.1	1.1	GO:0010454	negative regulation of cell fate commitment(GO:0010454)
0.1	0.5	GO:0007296	vitellogenesis(GO:0007296)
0.1	0.2	GO:0097091	synaptic vesicle clustering(GO:0097091)
0.1	0.3	GO:1904430	negative regulation of t-circle formation(GO:1904430)
0.1	0.2	GO:0090071	negative regulation of ribosome biogenesis(GO:0090071)
0.1	0.6	GO:0090085	regulation of protein deubiquitination(GO:0090085)
0.1	1.1	GO:0006517	protein deglycosylation(GO:0006517)
0.1	0.2	GO:0042723	thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.1	0.1	GO:0072553	terminal button organization(GO:0072553)
0.1	0.9	GO:0006622	protein targeting to lysosome(GO:0006622)
0.1	1.6	GO:0035855	megakaryocyte development(GO:0035855)
0.1	2.0	GO:0007340	acrosome reaction(GO:0007340)
0.1	0.5	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.1	0.4	GO:0035247	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) peptidyl-arginine omega-N-methylation(GO:0035247)
0.1	0.5	GO:0019695	choline metabolic process(GO:0019695)
0.1	0.2	GO:0003096	renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.1	0.3	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1	1.2	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.1	0.4	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.1	0.4	GO:0016584	nucleosome positioning(GO:0016584)
0.1	0.3	GO:0042126	nitrate metabolic process(GO:0042126)
0.1	0.3	GO:0030578	PML body organization(GO:0030578)
0.1	3.5	GO:0008306	associative learning(GO:0008306)
0.1	0.4	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1	0.2	GO:0048550	negative regulation of pinocytosis(GO:0048550)
0.1	0.1	GO:1904587	glycoprotein ERAD pathway(GO:0097466) response to glycoprotein(GO:1904587)
0.1	0.4	GO:0002051	osteoblast fate commitment(GO:0002051)
0.1	0.2	GO:0072289	metanephric nephron tubule formation(GO:0072289)
0.1	0.2	GO:0060700	regulation of ribonuclease activity(GO:0060700)
0.1	0.2	GO:0070827	chromatin maintenance(GO:0070827)
0.1	0.4	GO:0021999	neural plate anterior/posterior regionalization(GO:0021999)
0.1	0.1	GO:0046684	response to pyrethroid(GO:0046684)
0.1	0.2	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.1	0.1	GO:0007228	positive regulation of hh target transcription factor activity(GO:0007228)
0.1	0.2	GO:1903753	negative regulation of p38MAPK cascade(GO:1903753)
0.1	0.2	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.1	0.8	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1	0.2	GO:1903660	regulation of complement-dependent cytotoxicity(GO:1903659) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.1	0.3	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.1	0.2	GO:0032079	positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1	0.3	GO:0034650	cortisol metabolic process(GO:0034650)
0.1	0.4	GO:0021796	cerebral cortex regionalization(GO:0021796)
0.1	0.1	GO:0071332	cellular response to fructose stimulus(GO:0071332)
0.1	0.3	GO:0002318	myeloid progenitor cell differentiation(GO:0002318)
0.1	0.1	GO:0051938	L-glutamate import(GO:0051938)
0.1	0.4	GO:0035826	rubidium ion transport(GO:0035826)
0.1	0.1	GO:2001016	positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.1	0.2	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.1	0.6	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1	4.2	GO:0014065	phosphatidylinositol 3-kinase signaling(GO:0014065)
0.1	0.5	GO:0045217	cell-cell junction maintenance(GO:0045217)
0.1	0.1	GO:0051799	negative regulation of hair follicle development(GO:0051799) hair follicle placode formation(GO:0060789)
0.1	0.4	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.1	4.3	GO:0000187	activation of MAPK activity(GO:0000187)
0.1	0.3	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.1	0.1	GO:0060693	regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.1	1.0	GO:0003323	type B pancreatic cell development(GO:0003323)
0.1	0.3	GO:0001778	plasma membrane repair(GO:0001778)
0.1	0.1	GO:0001827	inner cell mass cell fate commitment(GO:0001827)
0.1	0.9	GO:0030177	positive regulation of Wnt signaling pathway(GO:0030177)
0.1	0.1	GO:0070671	response to interleukin-12(GO:0070671)
0.1	0.1	GO:0070368	positive regulation of hepatocyte differentiation(GO:0070368)
0.1	2.8	GO:0002028	regulation of sodium ion transport(GO:0002028)
0.1	0.4	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.1	1.5	GO:0042551	neuron maturation(GO:0042551)
0.1	0.2	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.1	0.2	GO:0043455	regulation of secondary metabolic process(GO:0043455)
0.1	0.6	GO:0034435	steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.1	0.4	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.1	0.3	GO:0032610	interleukin-1 alpha production(GO:0032610)
0.0	0.0	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.0	GO:1904016	response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0	0.3	GO:0021942	radial glia guided migration of Purkinje cell(GO:0021942)
0.0	0.2	GO:0042940	D-amino acid transport(GO:0042940)
0.0	0.0	GO:0071839	apoptotic process in bone marrow(GO:0071839)
0.0	0.0	GO:0002071	glandular epithelial cell maturation(GO:0002071)
0.0	0.2	GO:0045636	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of developmental pigmentation(GO:0048087) positive regulation of pigment cell differentiation(GO:0050942)
0.0	0.1	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.2	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.1	GO:0060618	nipple development(GO:0060618)
0.0	0.4	GO:2000251	positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0	4.5	GO:0007050	cell cycle arrest(GO:0007050)
0.0	6.8	GO:0060070	canonical Wnt signaling pathway(GO:0060070)
0.0	0.4	GO:0051131	chaperone-mediated protein complex assembly(GO:0051131)
0.0	0.1	GO:1900368	regulation of RNA interference(GO:1900368)
0.0	0.1	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.2	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0071873	response to norepinephrine(GO:0071873)
0.0	0.1	GO:0018197	peptidyl-aspartic acid modification(GO:0018197)
0.0	0.1	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.5	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.2	GO:0048227	plasma membrane to endosome transport(GO:0048227)
0.0	0.3	GO:0034551	respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0	0.6	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.1	GO:0086036	regulation of cardiac muscle cell membrane potential(GO:0086036)
0.0	0.1	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.0	0.2	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.1	GO:1905154	negative regulation of membrane invagination(GO:1905154)
0.0	0.2	GO:0008343	adult feeding behavior(GO:0008343)
0.0	0.3	GO:1990001	inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0	0.4	GO:0007413	axonal fasciculation(GO:0007413)
0.0	1.5	GO:0061077	chaperone-mediated protein folding(GO:0061077)
0.0	0.1	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.0	0.2	GO:0031274	positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0032474	otolith morphogenesis(GO:0032474)
0.0	0.1	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.2	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.1	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.0	GO:0072205	metanephric collecting duct development(GO:0072205)
0.0	0.1	GO:0035984	response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
0.0	0.4	GO:0035278	miRNA mediated inhibition of translation(GO:0035278)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:0070459	prolactin secretion(GO:0070459)
0.0	0.0	GO:0072161	mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.1	GO:0033085	negative regulation of T cell differentiation in thymus(GO:0033085) negative regulation of thymocyte aggregation(GO:2000399)
0.0	0.1	GO:0031284	positive regulation of guanylate cyclase activity(GO:0031284)
0.0	0.1	GO:0033326	cerebrospinal fluid secretion(GO:0033326)
0.0	0.3	GO:1903861	regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
0.0	0.5	GO:0071475	cellular hyperosmotic salinity response(GO:0071475)
0.0	0.2	GO:0006287	base-excision repair, gap-filling(GO:0006287)
0.0	0.1	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.0	GO:0014054	positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.0	0.1	GO:0014816	skeletal muscle satellite cell differentiation(GO:0014816)
0.0	0.8	GO:0006270	DNA replication initiation(GO:0006270)
0.0	0.1	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	1.1	GO:0002088	lens development in camera-type eye(GO:0002088)
0.0	0.1	GO:0019086	late viral transcription(GO:0019086)
0.0	0.1	GO:0009158	ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0070920	regulation of production of small RNA involved in gene silencing by RNA(GO:0070920) regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798)
0.0	0.2	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0	0.1	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.3	GO:0061162	establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.0	0.4	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.0	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.0	0.1	GO:0044838	cell quiescence(GO:0044838)
0.0	0.3	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.1	GO:0006004	fucose metabolic process(GO:0006004)
0.0	0.3	GO:0019370	leukotriene biosynthetic process(GO:0019370)
0.0	0.2	GO:0006283	transcription-coupled nucleotide-excision repair(GO:0006283)
0.0	0.2	GO:0051503	purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503)
0.0	0.1	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.1	GO:0035993	deltoid tuberosity development(GO:0035993)
0.0	0.1	GO:1900045	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.1	GO:0003219	cardiac right ventricle formation(GO:0003219)
0.0	0.1	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.0	0.7	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.2	GO:0018298	protein-chromophore linkage(GO:0018298)
0.0	0.1	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.1	GO:0046078	dUMP metabolic process(GO:0046078)
0.0	0.4	GO:0046326	positive regulation of glucose import(GO:0046326)
0.0	0.1	GO:0003163	sinoatrial node development(GO:0003163) sinoatrial node cell differentiation(GO:0060921) sinoatrial node cell development(GO:0060931)
0.0	0.2	GO:0060856	establishment of blood-brain barrier(GO:0060856)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:0031860	telomeric 3' overhang formation(GO:0031860)
0.0	0.2	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.0	GO:2000275	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.0	0.0	GO:2000836	androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836)
0.0	0.1	GO:0002322	B cell proliferation involved in immune response(GO:0002322)
0.0	0.2	GO:0031571	mitotic G1 DNA damage checkpoint(GO:0031571)
0.0	0.1	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.0	0.1	GO:2001137	positive regulation of endocytic recycling(GO:2001137)
0.0	0.5	GO:0006836	neurotransmitter transport(GO:0006836)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.0	GO:0046532	regulation of photoreceptor cell differentiation(GO:0046532)
0.0	0.1	GO:0009233	menaquinone metabolic process(GO:0009233)
0.0	0.1	GO:0072395	signal transduction involved in cell cycle checkpoint(GO:0072395) signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422)
0.0	0.0	GO:0002741	positive regulation of cytokine secretion involved in immune response(GO:0002741)
0.0	0.1	GO:0097039	protein linear polyubiquitination(GO:0097039)
0.0	0.0	GO:0032344	regulation of aldosterone metabolic process(GO:0032344)
0.0	0.8	GO:0071427	mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0	0.1	GO:0071236	cellular response to antibiotic(GO:0071236)
0.0	0.0	GO:0003057	regulation of the force of heart contraction by chemical signal(GO:0003057)
0.0	0.0	GO:0051660	establishment of centrosome localization(GO:0051660)
0.0	0.1	GO:0035095	behavioral response to nicotine(GO:0035095)
0.0	0.2	GO:0009071	serine family amino acid catabolic process(GO:0009071)
0.0	0.1	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.3	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0000715	nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0	0.6	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.1	GO:0014072	response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.0	0.0	GO:0071321	cellular response to cGMP(GO:0071321)
0.0	0.0	GO:0006458	'de novo' protein folding(GO:0006458) 'de novo' posttranslational protein folding(GO:0051084)
0.0	0.1	GO:0071763	nuclear membrane organization(GO:0071763)
0.0	0.1	GO:0031017	exocrine pancreas development(GO:0031017)
0.0	0.1	GO:0021781	glial cell fate commitment(GO:0021781)
0.0	0.1	GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.0	0.5	GO:0032784	regulation of DNA-templated transcription, elongation(GO:0032784)
0.0	0.0	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.5	GO:0007528	neuromuscular junction development(GO:0007528)
0.0	0.1	GO:0072311	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0032049	cardiolipin biosynthetic process(GO:0032049)
0.0	0.0	GO:0070278	extracellular matrix constituent secretion(GO:0070278)
0.0	0.1	GO:2000321	positive regulation of T-helper 17 cell differentiation(GO:2000321)
0.0	0.1	GO:0032826	natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.0	0.2	GO:0030728	ovulation(GO:0030728)
0.0	0.1	GO:0090168	Golgi reassembly(GO:0090168)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.1	GO:0060837	blood vessel endothelial cell differentiation(GO:0060837)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.0	0.1	GO:0006548	histidine metabolic process(GO:0006547) histidine catabolic process(GO:0006548) imidazole-containing compound metabolic process(GO:0052803) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.0	GO:0030432	peristalsis(GO:0030432)
0.0	0.0	GO:0032286	central nervous system myelin maintenance(GO:0032286)
0.0	0.0	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.0	0.1	GO:0061469	regulation of type B pancreatic cell proliferation(GO:0061469)
0.0	0.0	GO:0050975	sensory perception of touch(GO:0050975) cellular response to temperature stimulus(GO:0071502)
0.0	0.0	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0	0.0	GO:0061156	pulmonary artery morphogenesis(GO:0061156)
0.0	0.1	GO:0050706	regulation of interleukin-1 beta secretion(GO:0050706)
0.0	0.5	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.0	0.2	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0010991	negative regulation of SMAD protein complex assembly(GO:0010991)
0.0	0.0	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0	0.0	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.0	GO:0009436	glyoxylate catabolic process(GO:0009436) glyoxylate metabolic process(GO:0046487)
0.0	0.7	GO:0048814	regulation of dendrite morphogenesis(GO:0048814)
0.0	0.0	GO:0015793	glycerol transport(GO:0015793)
0.0	0.3	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.2	GO:0048011	neurotrophin TRK receptor signaling pathway(GO:0048011)
0.0	0.1	GO:0018344	protein geranylgeranylation(GO:0018344)
0.0	0.2	GO:0040018	positive regulation of multicellular organism growth(GO:0040018)
0.0	0.0	GO:1904415	regulation of xenophagy(GO:1904415) positive regulation of xenophagy(GO:1904417)
0.0	0.1	GO:0060416	response to growth hormone(GO:0060416)
0.0	0.1	GO:0018095	protein polyglutamylation(GO:0018095)
0.0	0.1	GO:0031050	dsRNA fragmentation(GO:0031050) production of miRNAs involved in gene silencing by miRNA(GO:0035196) production of small RNA involved in gene silencing by RNA(GO:0070918)
0.0	0.9	GO:0090002	establishment of protein localization to plasma membrane(GO:0090002)
0.0	0.0	GO:0003433	chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.0	0.0	GO:0046104	thymidine metabolic process(GO:0046104)
0.0	0.1	GO:0021895	cerebral cortex neuron differentiation(GO:0021895)
0.0	0.0	GO:0001951	intestinal D-glucose absorption(GO:0001951)
0.0	0.1	GO:0016446	somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0	0.1	GO:0030222	eosinophil differentiation(GO:0030222)
0.0	0.0	GO:0002468	dendritic cell antigen processing and presentation(GO:0002468) regulation of dendritic cell antigen processing and presentation(GO:0002604) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.1	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.0	GO:0090427	embryonic nail plate morphogenesis(GO:0035880) activation of meiosis(GO:0090427)
0.0	0.1	GO:0030903	notochord development(GO:0030903)
0.0	0.0	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.0	0.1	GO:0046602	regulation of mitotic centrosome separation(GO:0046602)
0.0	0.1	GO:0007512	adult heart development(GO:0007512)
0.0	0.1	GO:0051382	kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.0	0.0	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.0	0.0	GO:0015816	glycine transport(GO:0015816)
0.0	0.3	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.0	0.2	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0	0.0	GO:2000327	regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0	0.0	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.0	GO:1901164	negative regulation of trophoblast cell migration(GO:1901164)
0.0	0.1	GO:0060765	regulation of androgen receptor signaling pathway(GO:0060765)
0.0	0.0	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	1.4	GO:0048515	spermatid differentiation(GO:0048515)
0.0	0.1	GO:1903358	regulation of Golgi organization(GO:1903358)
0.0	0.0	GO:0033299	secretion of lysosomal enzymes(GO:0033299)
0.0	0.1	GO:0001967	suckling behavior(GO:0001967)
0.0	0.0	GO:0017085	response to insecticide(GO:0017085)
0.0	0.0	GO:0016560	protein import into peroxisome matrix, docking(GO:0016560)
0.0	0.1	GO:0071260	cellular response to mechanical stimulus(GO:0071260)
0.0	0.3	GO:0061053	somite development(GO:0061053)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.2	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.1	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
0.0	0.0	GO:0060148	positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.0	0.2	GO:0006383	transcription from RNA polymerase III promoter(GO:0006383)
0.0	0.0	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
0.0	0.9	GO:0006457	protein folding(GO:0006457)
0.0	0.0	GO:0060075	regulation of resting membrane potential(GO:0060075)
0.0	0.0	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.0	GO:0039534	negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0	0.0	GO:1900451	positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0	0.0	GO:0010536	positive regulation of activation of Janus kinase activity(GO:0010536)
0.0	0.1	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.0	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.0	GO:0060448	dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.8	11.3	GO:0072534	perineuronal net(GO:0072534)
3.0	12.0	GO:0042583	chromaffin granule(GO:0042583)
3.0	9.0	GO:0038037	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
2.6	50.2	GO:0060077	inhibitory synapse(GO:0060077)
2.5	10.0	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
2.3	41.2	GO:0030673	axolemma(GO:0030673)
1.9	9.4	GO:0031428	box C/D snoRNP complex(GO:0031428)
1.7	19.2	GO:0044292	dendrite terminus(GO:0044292)
1.7	20.5	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
1.7	64.6	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.3	15.1	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
1.1	8.9	GO:1904115	axon cytoplasm(GO:1904115)
1.1	6.6	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.7	7.5	GO:0030061	mitochondrial crista(GO:0030061)
0.7	7.8	GO:0031045	dense core granule(GO:0031045)
0.6	9.7	GO:0097440	apical dendrite(GO:0097440)
0.6	20.6	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.6	7.4	GO:0032426	stereocilium tip(GO:0032426)
0.6	25.0	GO:0042734	presynaptic membrane(GO:0042734)
0.6	11.0	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.6	15.3	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.5	8.1	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.4	17.8	GO:0034707	chloride channel complex(GO:0034707)
0.4	2.6	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4	5.5	GO:0032839	dendrite cytoplasm(GO:0032839)
0.3	0.9	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.3	4.7	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.3	3.5	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.3	11.7	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.2	6.6	GO:0031941	filamentous actin(GO:0031941)
0.2	0.7	GO:0071001	U4/U6 snRNP(GO:0071001)
0.2	8.7	GO:0099572	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.2	2.4	GO:0043196	varicosity(GO:0043196)
0.2	6.7	GO:0031201	SNARE complex(GO:0031201)
0.1	1.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.1	16.6	GO:0045211	postsynaptic membrane(GO:0045211)
0.1	1.1	GO:0030314	junctional membrane complex(GO:0030314)
0.1	7.0	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	1.5	GO:0044295	axonal growth cone(GO:0044295)
0.1	0.7	GO:0016272	prefoldin complex(GO:0016272)
0.1	4.3	GO:0008287	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.1	0.3	GO:0072558	NLRP1 inflammasome complex(GO:0072558)
0.1	1.4	GO:0032590	dendrite membrane(GO:0032590)
0.1	0.5	GO:0032584	growth cone membrane(GO:0032584)
0.1	0.2	GO:0097513	myosin II filament(GO:0097513)
0.1	3.9	GO:0032587	ruffle membrane(GO:0032587)
0.1	0.9	GO:0042555	MCM complex(GO:0042555)
0.1	0.3	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.1	1.0	GO:0033391	chromatoid body(GO:0033391)
0.1	0.7	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.1	1.6	GO:0030665	clathrin-coated vesicle membrane(GO:0030665)
0.1	0.2	GO:0097524	sperm plasma membrane(GO:0097524)
0.1	21.4	GO:0030425	dendrite(GO:0030425)
0.1	0.3	GO:0033010	paranodal junction(GO:0033010)
0.1	0.2	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.1	0.3	GO:0089701	U2AF(GO:0089701)
0.1	0.1	GO:0097454	Schwann cell microvillus(GO:0097454)
0.1	0.2	GO:0005826	actomyosin contractile ring(GO:0005826)
0.1	0.2	GO:0032585	multivesicular body membrane(GO:0032585)
0.1	0.2	GO:0071797	LUBAC complex(GO:0071797)
0.1	0.4	GO:0070187	telosome(GO:0070187)
0.0	0.5	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.3	GO:0044214	spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0	0.6	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	4.8	GO:0035068	micro-ribonucleoprotein complex(GO:0035068)
0.0	0.0	GO:0044393	microspike(GO:0044393)
0.0	0.1	GO:0071547	piP-body(GO:0071547)
0.0	0.1	GO:0071598	neuronal ribonucleoprotein granule(GO:0071598)
0.0	0.1	GO:0061689	tricellular tight junction(GO:0061689)
0.0	0.3	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	2.5	GO:0005581	collagen trimer(GO:0005581)
0.0	0.2	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0	0.1	GO:0019815	B cell receptor complex(GO:0019815)
0.0	0.6	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	0.2	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	0.1	GO:0020016	ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0	0.1	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	0.2	GO:0000805	X chromosome(GO:0000805)
0.0	0.3	GO:1990023	mitotic spindle midzone(GO:1990023)
0.0	0.1	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.3	GO:0043034	costamere(GO:0043034)
0.0	0.2	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	0.0	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	0.1	GO:0001652	granular component(GO:0001652)
0.0	0.2	GO:0097208	alveolar lamellar body(GO:0097208)
0.0	0.0	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.1	GO:0043203	axon hillock(GO:0043203)
0.0	0.0	GO:0044462	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.1	GO:0043194	axon initial segment(GO:0043194)
0.0	0.1	GO:0072687	meiotic spindle(GO:0072687)
0.0	0.0	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.0	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.1	GO:0097452	GAIT complex(GO:0097452)
0.0	0.1	GO:0000812	Swr1 complex(GO:0000812)
0.0	0.0	GO:0036195	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0	0.0	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.2	GO:0032420	stereocilium(GO:0032420)
0.0	0.0	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.0	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.0	GO:0005608	laminin-3 complex(GO:0005608)
0.0	0.1	GO:0016600	flotillin complex(GO:0016600)
0.0	0.3	GO:0031594	neuromuscular junction(GO:0031594)
0.0	0.1	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	0.0	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0070847	core mediator complex(GO:0070847)
0.0	0.1	GO:0060091	kinocilium(GO:0060091)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.1	GO:0061702	inflammasome complex(GO:0061702)
0.0	0.2	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.0	GO:0033186	CAF-1 complex(GO:0033186)
0.0	0.0	GO:1990696	USH2 complex(GO:1990696)
0.0	0.0	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.0	GO:0097512	cardiac myofibril(GO:0097512)
0.0	5.8	GO:0016023	cytoplasmic, membrane-bounded vesicle(GO:0016023)
0.0	0.4	GO:0005876	spindle microtubule(GO:0005876)
0.0	0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.0	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.0	3.5	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.0	0.1	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.1	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
0.0	0.5	GO:0030426	growth cone(GO:0030426)
0.0	0.0	GO:0097149	centralspindlin complex(GO:0097149)
0.0	1.3	GO:0042579	peroxisome(GO:0005777) microbody(GO:0042579)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
6.2	18.5	GO:0097109	neuroligin family protein binding(GO:0097109)
5.9	23.4	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
4.4	26.2	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
3.0	15.0	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
2.4	7.2	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
2.3	11.6	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
2.2	13.3	GO:0005499	vitamin D binding(GO:0005499)
2.0	21.8	GO:0031681	G-protein beta-subunit binding(GO:0031681)
1.7	6.7	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
1.7	13.3	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
1.6	4.8	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
1.6	4.7	GO:0004793	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
1.5	16.8	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
1.5	4.4	GO:0004351	glutamate decarboxylase activity(GO:0004351)
1.4	17.2	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313)
1.3	3.9	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
1.0	19.4	GO:0004890	GABA-A receptor activity(GO:0004890)
1.0	8.9	GO:0098988	G-protein coupled glutamate receptor activity(GO:0098988)
0.9	7.2	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)
0.9	6.2	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.9	6.9	GO:0008430	selenium binding(GO:0008430)
0.8	7.5	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.7	14.9	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.6	8.8	GO:0046625	sphingolipid binding(GO:0046625)
0.6	1.9	GO:0051430	corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.6	19.2	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.6	2.4	GO:0001602	pancreatic polypeptide receptor activity(GO:0001602)
0.6	6.7	GO:0031005	filamin binding(GO:0031005)
0.6	0.6	GO:0070905	serine binding(GO:0070905)
0.5	10.1	GO:0017075	syntaxin-1 binding(GO:0017075)
0.5	6.0	GO:0004993	G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.5	8.5	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.5	8.1	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.4	1.3	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4	4.6	GO:0015643	toxic substance binding(GO:0015643)
0.4	1.4	GO:0046923	ER retention sequence binding(GO:0046923)
0.3	16.7	GO:0030276	clathrin binding(GO:0030276)
0.3	11.9	GO:0035254	glutamate receptor binding(GO:0035254)
0.3	5.6	GO:0005112	Notch binding(GO:0005112)
0.3	0.9	GO:0003976	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.3	1.5	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.3	7.2	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.3	5.2	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.3	1.3	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.3	6.4	GO:0046875	ephrin receptor binding(GO:0046875)
0.2	3.2	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.2	0.7	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2	0.7	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.2	0.9	GO:0004985	opioid receptor activity(GO:0004985)
0.2	0.6	GO:0018593	fluorene oxygenase activity(GO:0018585) mono-butyltin dioxygenase activity(GO:0018586) tri-n-butyltin dioxygenase activity(GO:0018588) di-n-butyltin dioxygenase activity(GO:0018589) methylsilanetriol hydroxylase activity(GO:0018590) methyl tertiary butyl ether 3-monooxygenase activity(GO:0018591) 4-nitrocatechol 4-monooxygenase activity(GO:0018592) 4-chlorophenoxyacetate monooxygenase activity(GO:0018593) tert-butanol 2-monooxygenase activity(GO:0018594) alpha-pinene monooxygenase activity(GO:0018595) dimethylsilanediol hydroxylase activity(GO:0018596) ammonia monooxygenase activity(GO:0018597) hydroxymethylsilanetriol oxidase activity(GO:0018598) 2-hydroxyisobutyrate 3-monooxygenase activity(GO:0018599) alpha-pinene dehydrogenase activity(GO:0018600) bisphenol A hydroxylase B activity(GO:0034559) 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity(GO:0034562) 9-fluorenone-3,4-dioxygenase activity(GO:0034786) anthracene 9,10-dioxygenase activity(GO:0034816) 2-(methylthio)benzothiazole monooxygenase activity(GO:0034857) 2-hydroxybenzothiazole monooxygenase activity(GO:0034858) benzothiazole monooxygenase activity(GO:0034859) 2,6-dihydroxybenzothiazole monooxygenase activity(GO:0034862) pinacolone 5-monooxygenase activity(GO:0034870) thioacetamide S-oxygenase activity(GO:0034873) thioacetamide S-oxide S-oxygenase activity(GO:0034874) endosulfan monooxygenase I activity(GO:0034888) N-nitrodimethylamine hydroxylase activity(GO:0034893) 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity(GO:0034897) endosulfan ether monooxygenase activity(GO:0034903) pyrene 4,5-monooxygenase activity(GO:0034925) pyrene 1,2-monooxygenase activity(GO:0034927) 1-hydroxypyrene 6,7-monooxygenase activity(GO:0034928) 1-hydroxypyrene 7,8-monooxygenase activity(GO:0034929) phenylboronic acid monooxygenase activity(GO:0034950) spheroidene monooxygenase activity(GO:0043823)
0.2	0.8	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2	0.6	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2	9.7	GO:0042054	histone methyltransferase activity(GO:0042054)
0.2	0.6	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.2	8.9	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2	10.3	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.2	5.4	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.2	4.7	GO:0045296	cadherin binding(GO:0045296)
0.2	0.3	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.2	2.4	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.2	0.5	GO:0004103	choline kinase activity(GO:0004103)
0.2	4.8	GO:0017147	Wnt-protein binding(GO:0017147)
0.2	5.0	GO:0015485	cholesterol binding(GO:0015485)
0.2	1.2	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.1	0.4	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.1	1.2	GO:0042300	pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011)
0.1	0.6	GO:1990254	keratin filament binding(GO:1990254)
0.1	0.4	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.1	3.7	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.1	0.1	GO:0015563	uptake transmembrane transporter activity(GO:0015563)
0.1	0.4	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.1	2.0	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.1	8.9	GO:0000149	SNARE binding(GO:0000149)
0.1	0.4	GO:0015377	cation:chloride symporter activity(GO:0015377)
0.1	1.7	GO:0016854	racemase and epimerase activity(GO:0016854)
0.1	21.9	GO:0003729	mRNA binding(GO:0003729)
0.1	2.7	GO:0005246	calcium channel regulator activity(GO:0005246)
0.1	4.0	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.1	0.3	GO:0046538	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1	0.5	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.1	1.3	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.1	0.2	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.1	0.7	GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1	1.8	GO:0034594	phosphatidylinositol trisphosphate phosphatase activity(GO:0034594)
0.1	0.5	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.1	0.3	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.1	0.6	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.1	0.3	GO:0000253	3-keto sterol reductase activity(GO:0000253)
0.1	0.6	GO:0003688	DNA replication origin binding(GO:0003688)
0.1	0.3	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1	5.5	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.1	0.3	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1	0.3	GO:0019145	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.1	8.3	GO:0002020	protease binding(GO:0002020)
0.1	0.3	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.1	4.8	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1	0.5	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.1	6.5	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.1	0.2	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.1	0.6	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1	0.2	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.1	0.2	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	0.2	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.1	0.1	GO:0034584	piRNA binding(GO:0034584)
0.1	5.1	GO:0001158	enhancer sequence-specific DNA binding(GO:0001158)
0.1	0.1	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.1	0.8	GO:0010181	FMN binding(GO:0010181)
0.1	0.1	GO:0034191	apolipoprotein A-I receptor binding(GO:0034191)
0.1	1.4	GO:0005212	structural constituent of eye lens(GO:0005212)
0.1	1.1	GO:0051183	vitamin transporter activity(GO:0051183)
0.1	0.2	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.1	0.1	GO:0071532	ankyrin repeat binding(GO:0071532)
0.1	1.3	GO:0008483	transaminase activity(GO:0008483)
0.1	0.3	GO:0050811	GABA receptor binding(GO:0050811)
0.1	0.1	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.1	0.1	GO:0070840	dynein complex binding(GO:0070840)
0.1	2.8	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0	0.3	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.0	1.0	GO:0052769	dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.0	0.1	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.0	0.2	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.4	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0	0.1	GO:0019862	IgA binding(GO:0019862)
0.0	0.2	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.9	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.1	GO:0043262	adenosine-diphosphatase activity(GO:0043262)
0.0	0.3	GO:0052630	CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.0	0.1	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	1.0	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0034618	arginine binding(GO:0034618)
0.0	0.2	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.3	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.1	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0	0.3	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.3	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.6	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.1	GO:0019960	C-X3-C chemokine binding(GO:0019960)
0.0	0.2	GO:0015216	adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) purine nucleotide transmembrane transporter activity(GO:0015216)
0.0	5.8	GO:0005261	cation channel activity(GO:0005261)
0.0	1.0	GO:0052635	sulfonate dioxygenase activity(GO:0000907) 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity(GO:0018602) hypophosphite dioxygenase activity(GO:0034792) gibberellin 2-beta-dioxygenase activity(GO:0045543) C-19 gibberellin 2-beta-dioxygenase activity(GO:0052634) C-20 gibberellin 2-beta-dioxygenase activity(GO:0052635)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0030572	cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.0	0.1	GO:0001031	RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084)
0.0	0.8	GO:0070566	adenylyltransferase activity(GO:0070566)
0.0	0.1	GO:0004565	beta-galactosidase activity(GO:0004565)
0.0	0.1	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0	0.0	GO:0010858	calcium-dependent protein kinase regulator activity(GO:0010858)
0.0	0.6	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0	0.1	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0	0.7	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0035473	lipase binding(GO:0035473)
0.0	0.6	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.0	0.4	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.4	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.3	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.2	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0	0.2	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0	0.2	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.1	GO:0035651	AP-3 adaptor complex binding(GO:0035651)
0.0	0.6	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.0	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	0.1	GO:1990226	histone methyltransferase binding(GO:1990226)
0.0	1.3	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.1	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.1	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.1	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.0	0.2	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0019958	C-X-C chemokine binding(GO:0019958)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.0	GO:0001016	RNA polymerase III regulatory region DNA binding(GO:0001016)
0.0	0.1	GO:0015211	purine nucleoside transmembrane transporter activity(GO:0015211)
0.0	0.1	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.2	GO:0050681	androgen receptor binding(GO:0050681)
0.0	0.0	GO:0051434	BH3 domain binding(GO:0051434)
0.0	0.3	GO:0005537	mannose binding(GO:0005537)
0.0	0.0	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0	3.2	GO:0015631	tubulin binding(GO:0015631)
0.0	0.0	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.5	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	3.2	GO:0030246	carbohydrate binding(GO:0030246)
0.0	0.0	GO:0051429	corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.0	0.5	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0071987	WD40-repeat domain binding(GO:0071987)
0.0	0.2	GO:0070180	large ribosomal subunit rRNA binding(GO:0070180)
0.0	0.0	GO:0000182	rDNA binding(GO:0000182)
0.0	0.0	GO:0070878	primary miRNA binding(GO:0070878)
0.0	0.0	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.0	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.0	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0	0.6	GO:0017022	myosin binding(GO:0017022)
0.0	0.1	GO:0070411	I-SMAD binding(GO:0070411)
0.0	7.0	GO:0004930	G-protein coupled receptor activity(GO:0004930)
0.0	0.1	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.4	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	0.0	GO:0016262	protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.0	0.4	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
0.0	0.0	GO:0002046	opsin binding(GO:0002046)
0.0	0.1	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679)
0.0	0.1	GO:0070182	DNA polymerase binding(GO:0070182)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.0	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
0.0	0.1	GO:0001223	transcription coactivator binding(GO:0001223)
0.0	0.0	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.0	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0	0.1	GO:0098811	transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0	0.1	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.0	GO:0009374	biotin binding(GO:0009374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	22.0	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.4	4.7	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.4	22.0	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.2	1.2	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.2	5.9	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2	3.3	ST G ALPHA I PATHWAY	G alpha i Pathway
0.1	7.8	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	1.2	PID IGF1 PATHWAY	IGF1 pathway
0.1	2.0	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	2.2	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.1	5.5	PID NOTCH PATHWAY	Notch signaling pathway
0.1	2.2	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	0.5	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.1	0.2	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.1	2.5	PID CDC42 PATHWAY	CDC42 signaling events
0.1	6.8	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	2.7	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	0.4	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.0	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	0.4	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	0.2	ST GAQ PATHWAY	G alpha q Pathway
0.0	1.3	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.0	0.7	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	0.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.1	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	0.2	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.6	PID ATR PATHWAY	ATR signaling pathway
0.0	0.8	NABA COLLAGENS	Genes encoding collagen proteins
0.0	0.4	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.6	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.3	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	0.3	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	0.2	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.0	0.5	PID BMP PATHWAY	BMP receptor signaling
0.0	0.1	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.0	0.4	PID P73PATHWAY	p73 transcription factor network
0.0	0.4	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	0.1	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.3	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	0.2	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.4	36.0	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
2.3	45.6	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
1.7	9.9	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
1.6	17.3	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
1.1	22.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.8	11.8	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.7	8.1	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.5	6.0	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.5	7.0	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.5	6.6	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.5	19.0	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.5	8.1	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.4	5.8	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.4	3.9	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.4	17.8	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.4	8.3	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3	3.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.3	7.3	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.2	5.5	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2	5.7	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.2	1.1	REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.2	3.5	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.2	1.9	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.2	1.7	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1	0.3	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.1	9.4	REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	Genes involved in Transmission across Chemical Synapses
0.1	2.3	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.1	1.2	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.1	2.0	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.1	0.1	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1	1.5	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	0.9	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.1	0.9	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.1	0.4	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.1	0.6	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.1	0.7	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.1	1.3	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.1	1.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	0.2	REACTOME HOST INTERACTIONS OF HIV FACTORS	Genes involved in Host Interactions of HIV factors
0.1	0.3	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	6.2	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	2.9	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	0.4	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.3	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.2	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.5	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.0	0.2	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.0	0.3	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.3	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	1.1	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.9	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0	0.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.1	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.5	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0	0.2	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.0	0.3	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.0	0.2	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.9	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.0	0.1	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	0.2	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.2	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.1	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	0.6	REACTOME EXTRACELLULAR MATRIX ORGANIZATION	Genes involved in Extracellular matrix organization
0.0	0.3	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.0	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.1	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	0.1	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling

Results for Rest

Z-value: 3.15

Motif logo

Transcription factors associated with Rest

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Rest motif across conditions

Conditions sorted by the z-value of the Rest motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Rest

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: