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ENCODE: ATAC-seq of different tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Tfap2b

Z-value: 1.26

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Transcription factors associated with Tfap2b

Gene Symbol	Gene ID	Gene Info
Tfap2b Ensembl NCBI MGI UniProt	ENSMUSG00000025927.7	transcription factor AP-2 beta

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Tfap2b	chr1_19226762_19226913	12958	0.186524	0.10	4.6e-01	Click!
Tfap2b	chr1_19217099_19217250	3295	0.253303	-0.04	7.7e-01	Click!
Tfap2b	chr1_19209073_19209255	204	0.944914	-0.03	8.3e-01	Click!
Tfap2b	chr1_19217371_19217862	3737	0.240551	-0.02	8.8e-01	Click!
Tfap2b	chr1_19205838_19205989	3001	0.265345	-0.01	9.3e-01	Click!

Activity of the Tfap2b motif across conditions

Conditions sorted by the z-value of the Tfap2b motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr18_3117365_3118622	18.50	Vmn1r238	vomeronasal 1 receptor, 238	5419	0.17
chr18_3116815_3117174	9.28	Vmn1r238	vomeronasal 1 receptor, 238	6418	0.16
chr18_20621651_20622570	7.89	Gm16090	predicted gene 16090	43150	0.11
chr7_12010381_12010846	6.83	Vmn1r-ps60	vomeronasal 1 receptor, pseudogene 60	5547	0.07
chr18_3116148_3116568	6.68	Vmn1r238	vomeronasal 1 receptor, 238	7054	0.16
chr18_20616739_20617639	6.31	Gm16090	predicted gene 16090	48071	0.1
chr18_3118971_3119257	6.29	Vmn1r238	vomeronasal 1 receptor, 238	4298	0.18
chr7_12012707_12013031	5.88	Vmn1r-ps60	vomeronasal 1 receptor, pseudogene 60	7803	0.06
chr18_3119520_3119704	5.57	Vmn1r238	vomeronasal 1 receptor, 238	3800	0.19
chr7_12012353_12012504	4.80	Vmn1r-ps60	vomeronasal 1 receptor, pseudogene 60	7362	0.06
chr18_20625060_20625736	4.03	Gm16090	predicted gene 16090	39862	0.12
chr18_3115836_3115987	3.31	Vmn1r238	vomeronasal 1 receptor, 238	7501	0.16
chr4_3165180_3165331	3.26	Vmn1r2	vomeronasal 1 receptor 2	2065	0.29
chr7_12011626_12011813	3.18	Vmn1r-ps60	vomeronasal 1 receptor, pseudogene 60	6653	0.07
chr18_3115468_3115789	2.86	Vmn1r238	vomeronasal 1 receptor, 238	7784	0.16
chr18_20615543_20616002	2.47	Gm16090	predicted gene 16090	49488	0.1
chr18_3118775_3118949	2.44	Vmn1r238	vomeronasal 1 receptor, 238	4550	0.18
chr4_3176842_3177034	2.30	Vmn1r2	vomeronasal 1 receptor 2	4855	0.19
chr18_80287426_80288075	1.50	Gm37015	predicted gene, 37015	15930	0.11
chr13_72833435_72833586	1.47	D730050B12Rik	RIKEN cDNA D730050B12 gene	16747	0.24
chr18_20627927_20628180	1.37	Gm16090	predicted gene 16090	37207	0.12
chr5_15672583_15672734	1.22	Speer4cos	spermatogenesis associated glutamate (E)-rich protein 4C, opposite strand transcript	8052	0.16
chr7_102025253_102025404	1.06	Rnf121	ring finger protein 121	859	0.42
chr18_20629240_20629391	1.05	Gm16090	predicted gene 16090	35945	0.13
chr5_15043056_15043231	1.04	Gm17019	predicted gene 17019	10145	0.25
chr7_74687595_74687746	1.01	Gm7726	predicted gene 7726	12186	0.26
chr5_14949256_14949587	1.00	Speer4e	spermatogenesis associated glutamate (E)-rich protein 4e	10992	0.19
chr3_53984780_53984955	0.98	Gm8109	predicted gene 8109	36297	0.15
chr18_20624320_20624587	0.96	Gm16090	predicted gene 16090	40807	0.12
chr5_15551399_15551801	0.94	Gm21190	predicted gene, 21190	22378	0.13
chr6_120539180_120540180	0.93	Hdhd5	haloacid dehalogenase like hydrolase domain containing 5	8361	0.12
chr18_20620820_20620971	0.91	Gm16090	predicted gene 16090	44365	0.11
chr4_136865069_136865433	0.90	C1qb	complement component 1, q subcomponent, beta polypeptide	20936	0.14
chr10_60692133_60692313	0.87	Cdh23	cadherin 23 (otocadherin)	4267	0.26
chr1_57218512_57218908	0.86	BC055402	cDNA sequence BC055402	3717	0.29
chr5_15608945_15609307	0.86	Gm30613	predicted gene, 30613	4060	0.18
chr17_61302066_61302300	0.86	Obox6-ps1	oocyte specific homeobox 6, pseudogene 1	58390	0.15
chr18_46484000_46484192	0.84	Gm24076	predicted gene, 24076	10072	0.13
chr18_20623022_20623191	0.82	Gm16090	predicted gene 16090	42154	0.12
chr13_54693536_54694669	0.81	Rnf44	ring finger protein 44	195	0.91
chr2_109693106_109694421	0.81	Bdnf	brain derived neurotrophic factor	200	0.94
chr1_194354828_194354979	0.81	4930503O07Rik	RIKEN cDNA 4930503O07 gene	132144	0.05
chr18_20626775_20626931	0.80	Gm16090	predicted gene 16090	38407	0.12
chr18_20626425_20626742	0.79	Gm16090	predicted gene 16090	38677	0.12
chr5_14988977_14989543	0.78	Gm10354	predicted gene 10354	10325	0.21
chr6_107713625_107713778	0.77	4933431M02Rik	RIKEN cDNA 4933431M02 gene	85927	0.09
chr6_75281622_75281787	0.76	Gm6210	predicted gene 6210	16355	0.25
chr18_20622786_20622961	0.73	Gm16090	predicted gene 16090	42387	0.11
chr9_10269175_10269351	0.73	Gm24496	predicted gene, 24496	21324	0.22
chr17_79605921_79606072	0.72	Rmdn2	regulator of microtubule dynamics 2	5867	0.28
chr2_156666341_156666675	0.71	Gm14172	predicted gene 14172	33040	0.1
chr2_74682809_74683583	0.71	Gm28309	predicted gene 28309	250	0.69
chr1_21960934_21962001	0.70	Kcnq5	potassium voltage-gated channel, subfamily Q, member 5	114	0.98
chr1_138837789_138838010	0.70	Lhx9	LIM homeobox protein 9	4240	0.17
chr2_59562684_59563070	0.69	Gm13552	predicted gene 13552	1807	0.42
chr7_67372280_67373557	0.68	Mef2a	myocyte enhancer factor 2A	60	0.97
chr18_20618066_20618220	0.67	Gm16090	predicted gene 16090	47117	0.11
chr19_43616167_43616368	0.66	Nkx2-3	NK2 homeobox 3	3942	0.13
chr2_126555283_126555434	0.65	Slc27a2	solute carrier family 27 (fatty acid transporter), member 2	770	0.66
chr9_8900765_8902148	0.64	Pgr	progesterone receptor	988	0.68
chr17_25609260_25609765	0.63	Lmf1	lipase maturation factor 1	30192	0.07
chr14_122474708_122475243	0.63	2610035F20Rik	RIKEN cDNA 2610035F20 gene	224	0.69
chr15_27814807_27814975	0.62	Trio	triple functional domain (PTPRF interacting)	8892	0.22
chr2_32317120_32318698	0.62	Gm23363	predicted gene, 23363	356	0.45
chr2_106692893_106694599	0.61	Mpped2	metallophosphoesterase domain containing 2	477	0.85
chr7_68311669_68311820	0.61	4930405G09Rik	RIKEN cDNA 4930405G09 gene	5288	0.14
chr18_20620535_20620686	0.61	Gm16090	predicted gene 16090	44650	0.11
chr1_82634564_82634787	0.60	n-R5s213	nuclear encoded rRNA 5S 213	338	0.87
chr18_20626992_20627160	0.60	Gm16090	predicted gene 16090	38184	0.12
chr7_49560224_49560375	0.59	Nav2	neuron navigator 2	6407	0.28
chr10_121475538_121476618	0.58	Rassf3	Ras association (RalGDS/AF-6) domain family member 3	269	0.86
chr17_35425252_35425979	0.57	H2-Q6	histocompatibility 2, Q region locus 6	738	0.41
chr4_147349805_147350010	0.57	Zfp978	zinc finger protein 978	11396	0.13
chr10_126978694_126979699	0.57	Ctdsp2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	167	0.89
chr5_122092798_122093169	0.57	Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	7968	0.14
chr17_47878037_47879117	0.56	Foxp4	forkhead box P4	376	0.81
chr3_132949340_132950694	0.56	Npnt	nephronectin	26	0.97
chr8_66486037_66486995	0.56	Tma16	translation machinery associated 16	3	0.97
chr12_112125881_112126258	0.55	Mir203	microRNA 203	4811	0.13
chr10_96460717_96460875	0.55	Gm8601	predicted gene 8601	15683	0.19
chr3_122729485_122730960	0.55	Pde5a	phosphodiesterase 5A, cGMP-specific	0	0.98
chr8_97633073_97633363	0.54	Gm7191	predicted gene 7191	66626	0.14
chr2_44920846_44920997	0.54	Gtdc1	glycosyltransferase-like domain containing 1	6228	0.29
chr8_122610722_122612153	0.54	Galns	galactosamine (N-acetyl)-6-sulfate sulfatase	26	0.7
chr8_15027100_15028701	0.53	Gm37844	predicted gene, 37844	522	0.44
chr9_23487032_23487234	0.53	Bmper	BMP-binding endothelial regulator	113201	0.07
chr18_20627726_20627877	0.53	Gm16090	predicted gene 16090	37459	0.12
chr9_91378183_91378872	0.53	Zic4	zinc finger protein of the cerebellum 4	115	0.94
chr17_28553454_28553746	0.53	Clpsl2	colipase-like 2	4189	0.09
chr3_130839108_130839269	0.53	Gm5982	predicted gene 5982	7785	0.12
chr6_125157136_125157596	0.52	Iffo1	intermediate filament family orphan 1	4018	0.08
chr9_59539422_59540161	0.51	Tmem202	transmembrane protein 202	56	0.75
chr10_107271547_107272835	0.50	Lin7a	lin-7 homolog A (C. elegans)	203	0.96
chr11_21997009_21997356	0.50	Otx1	orthodenticle homeobox 1	4433	0.28
chr19_26977887_26978038	0.49	Gm50121	predicted gene, 50121	48019	0.16
chr12_29871996_29872873	0.49	Myt1l	myelin transcription factor 1-like	20886	0.24
chr5_125389083_125389845	0.49	Gm10382	predicted gene 10382	142	0.67
chr2_179292721_179292959	0.49	Gm14293	predicted gene 14293	52350	0.14
chr17_85628600_85628757	0.49	Six3	sine oculis-related homeobox 3	7647	0.15
chr5_43032065_43032228	0.48	Gm43700	predicted gene 43700	6090	0.19
chr15_76133386_76133744	0.47	BC024139	cDNA sequence BC024139	6969	0.09
chr15_102257553_102258012	0.47	Rarg	retinoic acid receptor, gamma	265	0.82
chr8_46740254_46741749	0.47	Irf2	interferon regulatory factor 2	735	0.53
chr1_189343290_189344052	0.47	Kcnk2	potassium channel, subfamily K, member 2	36	0.76
chr6_114968557_114970098	0.47	Vgll4	vestigial like family member 4	147	0.97
chr6_52245954_52246438	0.46	Hoxa11os	homeobox A11, opposite strand	25	0.82
chr16_90533266_90533417	0.46	Gm36001	predicted gene, 36001	17268	0.15
chr12_108906675_108906826	0.46	Wdr25	WD repeat domain 25	5982	0.13
chr16_17497025_17497176	0.46	Aifm3	apoptosis-inducing factor, mitochondrion-associated 3	2599	0.15
chr13_110230204_110230355	0.45	Rab3c	RAB3C, member RAS oncogene family	49871	0.16
chr7_57508956_57510254	0.45	Gabra5	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5	234	0.95
chr5_36100815_36100966	0.45	Psapl1	prosaposin-like 1	103131	0.07
chr10_107437084_107437235	0.45	Gm38117	predicted gene, 38117	200	0.95
chr17_17827653_17828872	0.45	Spaca6	sperm acrosome associated 6	938	0.31
chr5_123027620_123027774	0.44	Gm43412	predicted gene 43412	8303	0.09
chr14_14345884_14346978	0.44	Il3ra	interleukin 3 receptor, alpha chain	1	0.93
chr13_105256983_105257274	0.44	Rnf180	ring finger protein 180	13911	0.24
chr11_5835203_5835354	0.44	Polm	polymerase (DNA directed), mu	1207	0.32
chr4_10883845_10884023	0.43	2610301B20Rik	RIKEN cDNA 2610301B20 gene	4395	0.16
chr16_73096919_73097070	0.43	4930500H12Rik	RIKEN cDNA 4930500H12 gene	1913	0.49
chr13_41705506_41705657	0.43	Gm5082	predicted gene 5082	49884	0.12
chr1_63273306_63273901	0.43	Gm24513	predicted gene, 24513	240	0.49
chr4_120170416_120170874	0.43	Edn2	endothelin 2	9439	0.24
chr1_18463225_18463376	0.43	Defb41	defensin beta 41	198162	0.02
chr18_68711266_68711468	0.42	Mir6356	microRNA 6356	28033	0.21
chr16_74182688_74182857	0.42	Gm49659	predicted gene, 49659	3938	0.24
chr10_122985267_122986641	0.42	D630033A02Rik	RIKEN cDNA D630033A02 gene	123	0.65
chr5_14914343_14915097	0.42	Gm9758	predicted gene 9758	133	0.97
chr5_136711274_136711425	0.42	Myl10	myosin, light chain 10, regulatory	13519	0.2
chr19_42764540_42764691	0.41	Hps1	HPS1, biogenesis of lysosomal organelles complex 3 subunit 1	739	0.61
chr9_22767838_22767989	0.41	Gm27639	predicted gene, 27639	4922	0.27
chr6_87898144_87898295	0.41	Copg1	coatomer protein complex, subunit gamma 1	416	0.7
chr3_40185875_40186026	0.41	1700017G19Rik	RIKEN cDNA 1700017G19 gene	323824	0.01
chr5_90988282_90988433	0.40	Epgn	epithelial mitogen	39107	0.11
chr4_154709923_154710074	0.40	Actrt2	actin-related protein T2	42131	0.11
chr14_36646374_36646525	0.40	Gm17940	predicted gene, 17940	27171	0.2
chr6_55335921_55336550	0.39	Aqp1	aquaporin 1	197	0.93
chr2_32390923_32391074	0.39	Lcn2	lipocalin 2	2746	0.12
chr2_31508651_31508802	0.39	Ass1	argininosuccinate synthetase 1	8000	0.18
chr10_87586828_87586979	0.38	Pah	phenylalanine hydroxylase	40230	0.16
chr5_15577027_15578025	0.38	Gm21083	predicted gene, 21083	193	0.93
chr13_56769978_56770289	0.38	Gm45623	predicted gene 45623	16306	0.21
chr3_116969934_116970085	0.38	Palmd	palmdelphin	1022	0.4
chr16_40652871_40653153	0.37	Gm27887	predicted gene, 27887	285075	0.01
chr19_3392510_3392690	0.37	Tesmin	testis expressed metallothionein like	3221	0.18
chr15_103334189_103334404	0.36	Zfp385a	zinc finger protein 385A	31	0.95
chr1_129272928_129273957	0.36	Thsd7b	thrombospondin, type I, domain containing 7B	21	0.98
chr5_114743003_114743280	0.36	Git2	GIT ArfGAP 2	727	0.5
chr11_95247117_95247412	0.36	Tac4	tachykinin 4	14265	0.13
chr6_118593411_118594059	0.36	Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	1691	0.37
chr1_172019892_172020043	0.35	Vangl2	VANGL planar cell polarity 2	6744	0.14
chr5_52604627_52604846	0.35	8030423F21Rik	RIKEN cDNA 8030423F21 gene	14276	0.14
chr10_29534276_29534889	0.35	Gm48159	predicted gene, 48159	135	0.94
chr3_30108418_30108578	0.35	Mecom	MDS1 and EVI1 complex locus	31925	0.17
chr8_80057499_80058156	0.34	Hhip	Hedgehog-interacting protein	179	0.95
chr7_62420605_62420845	0.34	Mkrn3	makorin, ring finger protein, 3	586	0.68
chr5_15032326_15032654	0.34	Gm17019	predicted gene 17019	508	0.84
chr12_8063506_8063657	0.33	Apob	apolipoprotein B	51222	0.14
chr6_119479409_119481030	0.33	Fbxl14	F-box and leucine-rich repeat protein 14	551	0.78
chr10_32889642_32890523	0.33	Nkain2	Na+/K+ transporting ATPase interacting 2	234	0.95
chr2_105126173_105126893	0.33	Wt1	Wilms tumor 1 homolog	4	0.5
chr16_90283526_90284553	0.33	Scaf4	SR-related CTD-associated factor 4	269	0.9
chr1_194769289_194769440	0.33	Plxna2	plexin A2	4797	0.2
chr11_116436453_116437309	0.33	Ubald2	UBA-like domain containing 2	2372	0.17
chr1_134182287_134182438	0.33	Chil1	chitinase-like 1	42	0.97
chr13_89371778_89371957	0.33	Hapln1	hyaluronan and proteoglycan link protein 1	167929	0.04
chr6_99520900_99522395	0.33	Foxp1	forkhead box P1	485	0.83
chr13_69261120_69261271	0.33	Gm4812	predicted gene 4812	84460	0.08
chr11_115889200_115889351	0.32	Myo15b	myosin XVB	964	0.35
chr5_13470497_13470849	0.32	Gm43130	predicted gene 43130	10355	0.22
chr5_113492671_113492876	0.32	Wscd2	WSC domain containing 2	2021	0.38
chr2_28566649_28566800	0.32	Cel	carboxyl ester lipase	3321	0.12
chr14_120389109_120389704	0.32	Gm26679	predicted gene, 26679	421	0.87
chr11_84879754_84880861	0.32	Myo19	myosin XIX	3	0.5
chr13_119741850_119742224	0.32	Nim1k	NIM1 serine/threonine protein kinase	3643	0.15
chr5_119743739_119744135	0.31	Tbx3os2	T-box 3, opposite strand 2	52719	0.1
chr11_74896307_74898160	0.31	Sgsm2	small G protein signaling modulator 2	173	0.84
chr9_61549545_61549892	0.31	Gm34424	predicted gene, 34424	16303	0.23
chr12_32995168_32995399	0.31	Gm24922	predicted gene, 24922	4727	0.16
chr3_135581620_135581778	0.31	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	12742	0.16
chr8_105604817_105605984	0.31	Ripor1	RHO family interacting cell polarization regulator 1	145	0.9
chr4_110152119_110152431	0.31	Elavl4	ELAV like RNA binding protein 4	70873	0.12
chr2_131040943_131041967	0.31	Gfra4	glial cell line derived neurotrophic factor family receptor alpha 4	2	0.94
chr7_25729452_25729603	0.31	Ccdc97	coiled-coil domain containing 97	10439	0.09
chr15_96474728_96474879	0.31	Scaf11	SR-related CTD-associated factor 11	13960	0.19
chr1_135771295_135771469	0.31	Phlda3	pleckstrin homology like domain, family A, member 3	4248	0.17
chr1_190042210_190042373	0.30	Smyd2	SET and MYND domain containing 2	119928	0.05
chr9_56657298_56657483	0.30	Lingo1	leucine rich repeat and Ig domain containing 1	9730	0.21
chr10_94943541_94945198	0.30	Plxnc1	plexin C1	466	0.84
chr4_147397309_147397460	0.30	Gm8178	predicted gene 8178	18455	0.13
chr8_84945228_84946066	0.30	Rtbdn	retbindin	1344	0.18
chr5_14978282_14978636	0.29	Gm10354	predicted gene 10354	476	0.83
chr1_141137215_141137503	0.29	Gm4845	predicted gene 4845	119798	0.06
chr5_137580251_137580513	0.29	Tfr2	transferrin receptor 2	1489	0.17
chr11_115831581_115831861	0.29	Llgl2	LLGL2 scribble cell polarity complex component	247	0.85
chr4_136144287_136145200	0.29	Id3	inhibitor of DNA binding 3	231	0.9
chr15_69107943_69108094	0.29	4930573C08Rik	RIKEN cDNA 4930573C08 gene	126981	0.05
chr8_69121372_69122097	0.29	Atp6v1b2	ATPase, H+ transporting, lysosomal V1 subunit B2	18606	0.14
chr5_137510563_137511218	0.29	Gm8066	predicted gene 8066	637	0.45
chr6_114131157_114131308	0.29	Slc6a11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	9	0.98

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	3.4	GO:0070327	thyroid hormone transport(GO:0070327)
0.4	2.3	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.2	0.7	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
0.2	0.9	GO:0007412	axon target recognition(GO:0007412)
0.2	0.5	GO:0097195	pilomotor reflex(GO:0097195)
0.2	0.5	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.2	0.5	GO:0071288	cellular response to mercury ion(GO:0071288)
0.2	0.5	GO:0055118	negative regulation of cardiac muscle contraction(GO:0055118)
0.1	0.4	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.1	0.7	GO:0060480	lung goblet cell differentiation(GO:0060480)
0.1	0.5	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.1	0.3	GO:0030242	pexophagy(GO:0030242)
0.1	0.3	GO:0035262	gonad morphogenesis(GO:0035262)
0.1	0.3	GO:0070889	platelet alpha granule organization(GO:0070889)
0.1	0.4	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.1	0.2	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.1	0.2	GO:1902956	regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902956)
0.1	0.3	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.1	0.2	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.1	0.1	GO:0001828	inner cell mass cellular morphogenesis(GO:0001828)
0.1	0.2	GO:0072050	S-shaped body morphogenesis(GO:0072050)
0.1	0.2	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.1	0.2	GO:0061031	endodermal digestive tract morphogenesis(GO:0061031)
0.1	0.2	GO:0001546	preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.1	0.1	GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0034499	late endosome to Golgi transport(GO:0034499)
0.0	0.2	GO:0036481	intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036481)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:2001055	positive regulation of mesenchymal cell apoptotic process(GO:2001055)
0.0	0.1	GO:2000474	regulation of opioid receptor signaling pathway(GO:2000474)
0.0	0.1	GO:0021524	visceral motor neuron differentiation(GO:0021524)
0.0	0.1	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.5	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0	0.0	GO:0043570	maintenance of DNA repeat elements(GO:0043570)
0.0	0.2	GO:0034454	microtubule anchoring at centrosome(GO:0034454)
0.0	0.2	GO:0048069	eye pigmentation(GO:0048069)
0.0	0.1	GO:1900451	positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0	0.2	GO:1902534	single-organism membrane invagination(GO:1902534)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.0	GO:0051795	positive regulation of catagen(GO:0051795)
0.0	0.1	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.1	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.0	0.4	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272)
0.0	0.1	GO:0002175	protein localization to paranode region of axon(GO:0002175)
0.0	0.1	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.1	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.0	0.1	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.0	0.0	GO:2001245	regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0	0.1	GO:0048696	regulation of collateral sprouting in absence of injury(GO:0048696)
0.0	0.1	GO:1900194	negative regulation of oocyte maturation(GO:1900194)
0.0	0.1	GO:1904016	response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0	0.1	GO:0010643	cell communication by chemical coupling(GO:0010643)
0.0	0.2	GO:0034227	tRNA thio-modification(GO:0034227)
0.0	0.1	GO:1903423	positive regulation of synaptic vesicle recycling(GO:1903423)
0.0	0.4	GO:0060044	negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0	0.2	GO:0043654	recognition of apoptotic cell(GO:0043654)
0.0	0.1	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.2	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.1	GO:0072553	terminal button organization(GO:0072553)
0.0	0.3	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.2	GO:0045217	cell-cell junction maintenance(GO:0045217)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.1	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.2	GO:0043045	DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0	0.4	GO:0060088	auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.1	GO:0048852	diencephalon morphogenesis(GO:0048852)
0.0	0.2	GO:0045634	regulation of melanocyte differentiation(GO:0045634)
0.0	0.0	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.0	0.1	GO:1900147	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0	0.1	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.1	GO:0042660	positive regulation of cell fate specification(GO:0042660)
0.0	0.1	GO:0072513	positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0	0.1	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0	0.1	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0	0.1	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:0021764	amygdala development(GO:0021764)
0.0	0.2	GO:0090308	regulation of methylation-dependent chromatin silencing(GO:0090308)
0.0	0.2	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.2	GO:0071493	cellular response to UV-B(GO:0071493)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.1	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.1	GO:0009240	isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0	0.1	GO:0002930	trabecular meshwork development(GO:0002930)
0.0	0.1	GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.0	1.0	GO:0006687	glycosphingolipid metabolic process(GO:0006687)
0.0	0.0	GO:0014016	neuroblast differentiation(GO:0014016)
0.0	0.1	GO:0043096	purine nucleobase salvage(GO:0043096)
0.0	0.0	GO:0046514	ceramide catabolic process(GO:0046514)
0.0	0.4	GO:0015812	gamma-aminobutyric acid transport(GO:0015812)
0.0	0.0	GO:0046103	inosine biosynthetic process(GO:0046103)
0.0	0.1	GO:0060179	male mating behavior(GO:0060179)
0.0	0.1	GO:0072205	metanephric collecting duct development(GO:0072205)
0.0	0.2	GO:0035413	positive regulation of catenin import into nucleus(GO:0035413)
0.0	0.2	GO:0036158	outer dynein arm assembly(GO:0036158)
0.0	0.1	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.0	GO:0072235	distal convoluted tubule development(GO:0072025) DCT cell differentiation(GO:0072069) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) metanephric DCT cell differentiation(GO:0072240)
0.0	0.0	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.2	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.1	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.0	0.2	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0	0.1	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.4	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	0.1	GO:0090210	regulation of establishment of blood-brain barrier(GO:0090210)
0.0	0.1	GO:1904667	negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.0	0.0	GO:0072034	renal vesicle induction(GO:0072034) metanephric nephron tubule formation(GO:0072289)
0.0	0.1	GO:0097466	glycoprotein ERAD pathway(GO:0097466) response to glycoprotein(GO:1904587)
0.0	0.1	GO:0060718	chorionic trophoblast cell differentiation(GO:0060718)
0.0	1.6	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0	0.1	GO:0051136	regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.1	GO:0010992	ubiquitin homeostasis(GO:0010992)
0.0	0.0	GO:0060751	branch elongation involved in mammary gland duct branching(GO:0060751)
0.0	0.1	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.1	GO:0030920	N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0	0.1	GO:0070948	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0098597	vocal learning(GO:0042297) imitative learning(GO:0098596) observational learning(GO:0098597) learned vocalization behavior or vocal learning(GO:0098598)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.0	GO:0060331	negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.0	0.1	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	0.0	GO:2000359	regulation of binding of sperm to zona pellucida(GO:2000359)
0.0	0.1	GO:0070627	ferrous iron import(GO:0070627)
0.0	0.0	GO:0035284	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.2	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0	0.1	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:0033578	protein glycosylation in Golgi(GO:0033578)
0.0	0.0	GO:1903935	response to sodium arsenite(GO:1903935)
0.0	0.1	GO:0045990	carbon catabolite regulation of transcription(GO:0045990)
0.0	0.1	GO:0003163	sinoatrial node development(GO:0003163)
0.0	0.1	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
0.0	0.1	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0	0.0	GO:0001692	histamine metabolic process(GO:0001692)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0051764	actin crosslink formation(GO:0051764)
0.0	0.0	GO:2000664	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.0	GO:0070827	chromatin maintenance(GO:0070827)
0.0	0.2	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.1	GO:0030836	positive regulation of actin filament depolymerization(GO:0030836)
0.0	0.1	GO:1903887	motile primary cilium assembly(GO:1903887)
0.0	0.0	GO:1902775	mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0	0.1	GO:0032049	cardiolipin biosynthetic process(GO:0032049)
0.0	0.0	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0	0.1	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.1	GO:0046543	development of secondary female sexual characteristics(GO:0046543)
0.0	0.1	GO:0007342	fusion of sperm to egg plasma membrane(GO:0007342)
0.0	0.1	GO:0006283	transcription-coupled nucleotide-excision repair(GO:0006283)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0031584	activation of phospholipase D activity(GO:0031584)
0.0	0.5	GO:0030148	sphingolipid biosynthetic process(GO:0030148)
0.0	0.0	GO:0006655	phosphatidylglycerol biosynthetic process(GO:0006655)
0.0	0.1	GO:0051654	establishment of mitochondrion localization(GO:0051654)
0.0	0.1	GO:0071918	urea transmembrane transport(GO:0071918)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0036065	fucosylation(GO:0036065)
0.0	0.0	GO:1902805	positive regulation of synaptic vesicle transport(GO:1902805)
0.0	0.1	GO:0071073	positive regulation of phospholipid biosynthetic process(GO:0071073)
0.0	0.0	GO:1901252	regulation of intracellular transport of viral material(GO:1901252)
0.0	0.1	GO:0046498	S-adenosylhomocysteine metabolic process(GO:0046498)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.0	0.1	GO:0021707	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.2	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway(GO:0040036)
0.0	0.0	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.0	GO:0046878	positive regulation of saliva secretion(GO:0046878)
0.0	0.4	GO:0072384	organelle transport along microtubule(GO:0072384)
0.0	0.1	GO:0016446	somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0	0.1	GO:1901142	insulin metabolic process(GO:1901142)
0.0	0.1	GO:0002070	epithelial cell maturation(GO:0002070)
0.0	0.0	GO:0060332	positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:1902222	L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0	0.1	GO:0090336	positive regulation of brown fat cell differentiation(GO:0090336)
0.0	0.0	GO:0034628	nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0	0.1	GO:0010224	response to UV-B(GO:0010224)
0.0	0.2	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.0	GO:0021540	corpus callosum morphogenesis(GO:0021540)
0.0	0.1	GO:1901160	serotonin metabolic process(GO:0042428) primary amino compound metabolic process(GO:1901160)
0.0	0.0	GO:1902988	neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996)
0.0	0.1	GO:0060576	intestinal epithelial cell development(GO:0060576)
0.0	1.1	GO:0019236	response to pheromone(GO:0019236)
0.0	0.0	GO:0044860	protein localization to plasma membrane raft(GO:0044860)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:0005914	spot adherens junction(GO:0005914)
0.2	3.3	GO:0030057	desmosome(GO:0030057)
0.1	0.3	GO:0032127	dense core granule membrane(GO:0032127)
0.1	0.5	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.1	0.9	GO:0030061	mitochondrial crista(GO:0030061)
0.1	0.3	GO:0030891	VCB complex(GO:0030891)
0.1	0.2	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1	0.2	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.1	0.3	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.4	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	0.1	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.2	GO:0001940	male pronucleus(GO:0001940)
0.0	0.4	GO:0097449	astrocyte projection(GO:0097449)
0.0	0.3	GO:0060091	kinocilium(GO:0060091)
0.0	0.5	GO:1902710	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0	0.2	GO:0071598	neuronal ribonucleoprotein granule(GO:0071598)
0.0	0.1	GO:0044326	dendritic spine neck(GO:0044326)
0.0	0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0044308	axonal spine(GO:0044308)
0.0	0.3	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.0	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.0	0.1	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.2	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.2	GO:0097470	ribbon synapse(GO:0097470)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.2	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0000439	core TFIIH complex(GO:0000439)
0.0	0.2	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.2	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.0	0.1	GO:0036157	outer dynein arm(GO:0036157)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.0	GO:0008275	gamma-tubulin small complex(GO:0008275)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.0	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.2	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	0.1	GO:0044232	organelle membrane contact site(GO:0044232)
0.0	0.1	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.3	GO:0000407	pre-autophagosomal structure(GO:0000407)
0.0	0.1	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.0	GO:0032280	symmetric synapse(GO:0032280)
0.0	0.0	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.0	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.2	GO:0043196	varicosity(GO:0043196)
0.0	0.0	GO:0097452	GAIT complex(GO:0097452)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	3.3	GO:0070324	thyroid hormone binding(GO:0070324)
0.2	0.5	GO:0097016	L27 domain binding(GO:0097016)
0.1	0.4	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1	0.3	GO:0097108	hedgehog family protein binding(GO:0097108)
0.1	0.9	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)
0.1	0.5	GO:0008420	CTD phosphatase activity(GO:0008420)
0.1	0.3	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1	0.3	GO:0045340	mercury ion binding(GO:0045340)
0.1	0.2	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.1	0.6	GO:0030553	cGMP binding(GO:0030553)
0.1	0.2	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.1	0.4	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.1	0.2	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.1	0.4	GO:0005223	intracellular cGMP activated cation channel activity(GO:0005223)
0.1	0.2	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.3	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.3	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.0	0.2	GO:0051434	BH3 domain binding(GO:0051434)
0.0	0.4	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0	0.1	GO:0031708	endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.1	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.1	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.2	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.4	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.0	0.2	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.2	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	0.3	GO:0004568	chitinase activity(GO:0004568)
0.0	0.3	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.2	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	1.0	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.0	0.2	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.4	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.2	GO:0032027	myosin light chain binding(GO:0032027)
0.0	0.5	GO:0004890	GABA-A receptor activity(GO:0004890)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.2	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.0	0.1	GO:0033142	progesterone receptor binding(GO:0033142)
0.0	0.8	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.0	1.4	GO:0035250	UDP-galactosyltransferase activity(GO:0035250)
0.0	0.1	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.2	GO:0046977	TAP binding(GO:0046977)
0.0	0.1	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
0.0	0.2	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.1	GO:0034711	inhibin binding(GO:0034711)
0.0	0.1	GO:1990190	peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.2	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.3	GO:0005452	inorganic anion exchanger activity(GO:0005452)
0.0	0.3	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.0	GO:0016262	protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.1	GO:0071532	ankyrin repeat binding(GO:0071532)
0.0	0.0	GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0	0.1	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.1	GO:0015265	urea channel activity(GO:0015265)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	2.4	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.0	0.1	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0	0.0	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.1	GO:0048019	receptor antagonist activity(GO:0048019)
0.0	0.0	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0	0.1	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.0	GO:0034547	N-cyclopropylmelamine deaminase activity(GO:0034547) N-cyclopropylammeline deaminase activity(GO:0034548) N-cyclopropylammelide alkylamino hydrolase activity(GO:0034549) 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity(GO:0043723) tRNA-specific adenosine-37 deaminase activity(GO:0043829) archaeal-specific GTP cyclohydrolase activity(GO:0044682) tRNA-specific adenosine-34 deaminase activity(GO:0052717)
0.0	0.2	GO:0004745	retinol dehydrogenase activity(GO:0004745)
0.0	0.0	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.0	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.0	0.0	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0031005	filamin binding(GO:0031005)
0.0	1.1	GO:0005550	pheromone binding(GO:0005550)
0.0	0.0	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0016920	pyroglutamyl-peptidase activity(GO:0016920)
0.0	0.1	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.2	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.3	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.0	0.0	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.0	0.0	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.1	GO:0039706	co-receptor binding(GO:0039706)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0035613	RNA stem-loop binding(GO:0035613)
0.0	0.2	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.0	GO:0004966	galanin receptor activity(GO:0004966)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.3	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.0	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	1.1	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	0.0	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.3	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	0.3	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.6	PID BMP PATHWAY	BMP receptor signaling
0.0	0.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.6	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.3	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.3	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.6	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.2	ST ADRENERGIC	Adrenergic Pathway
0.0	0.1	PID ATM PATHWAY	ATM pathway
0.0	0.1	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	0.1	PID ALK1 PATHWAY	ALK1 signaling events
0.0	0.1	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.1	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.1	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.0	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2	3.4	REACTOME AMYLOIDS	Genes involved in Amyloids
0.1	0.8	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.4	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	0.3	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.0	0.0	REACTOME G1 S TRANSITION	Genes involved in G1/S Transition
0.0	0.4	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.2	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.0	0.4	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.3	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.3	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.6	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	0.3	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.4	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.6	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.1	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	0.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.5	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0	0.6	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.0	0.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.3	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.1	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.6	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	0.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.3	REACTOME KERATAN SULFATE KERATIN METABOLISM	Genes involved in Keratan sulfate/keratin metabolism
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.0	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.0	0.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.4	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	0.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.2	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	0.1	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins