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ENCODE: ATAC-seq of different tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Arnt2

Z-value: 0.41

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Transcription factors associated with Arnt2

Gene Symbol	Gene ID	Gene Info
Arnt2 Ensembl NCBI MGI UniProt	ENSMUSG00000015709.8	Arnt2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Arnt2	chr7_84372464_84372615	8	0.976165	-0.40	2.8e-03	Click!
Arnt2	chr7_84275389_84275540	407	0.831638	0.34	1.1e-02	Click!
Arnt2	chr7_84285970_84286121	3651	0.209795	-0.33	1.5e-02	Click!
Arnt2	chr7_84403485_84403681	6300	0.181922	-0.30	2.4e-02	Click!
Arnt2	chr7_84307654_84307850	3226	0.213132	-0.30	2.8e-02	Click!

Activity of the Arnt2 motif across conditions

Conditions sorted by the z-value of the Arnt2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr16_15253127_15253318	1.36	Gm5404	predicted gene 5404	34378	0.16
chr2_170130477_170131578	0.90	Zfp217	zinc finger protein 217	193	0.97
chr12_69437182_69437482	0.81	5830428M24Rik	RIKEN cDNA 5830428M24 gene	30060	0.12
chr1_85251281_85252082	0.77	C130026I21Rik	RIKEN cDNA C130026I21 gene	2867	0.17
chr14_115040506_115042372	0.75	Mir17hg	Mir17 host gene (non-protein coding)	1440	0.19
chr15_97042032_97042236	0.73	Slc38a4	solute carrier family 38, member 4	7953	0.28
chr2_152636359_152637068	0.67	Rem1	rad and gem related GTP binding protein 1	3746	0.1
chr19_23758061_23759360	0.65	Apba1	amyloid beta (A4) precursor protein binding, family A, member 1	177	0.94
chr1_69106914_69108095	0.64	Erbb4	erb-b2 receptor tyrosine kinase 4	252	0.82
chr1_85166981_85167344	0.57	Gm6264	predicted gene 6264	6299	0.11
chr7_71960732_71961203	0.55	1700011C11Rik	RIKEN cDNA 1700011C11 gene	206	0.9
chr11_36873121_36873272	0.55	Tenm2	teneurin transmembrane protein 2	70970	0.14
chr11_96414118_96414269	0.54	Gm11531	predicted gene 11531	22081	0.1
chr13_72419489_72419940	0.52	Rpl9-ps4	ribosomal protein L9, pseudogene 4	35626	0.14
chr13_73263734_73263998	0.50	Irx4	Iroquois homeobox 4	3369	0.2
chr7_44553417_44554082	0.49	Nr1h2	nuclear receptor subfamily 1, group H, member 2	41	0.92
chr1_85092888_85093459	0.48	Gm10553	predicted gene 10553	6339	0.1
chr14_19131787_19131938	0.47	Gm8582	predicted gene 8582	4062	0.15
chr8_122511564_122511947	0.47	Gm26497	predicted gene, 26497	8919	0.09
chr7_118491741_118492257	0.47	Itpripl2	inositol 1,4,5-triphosphate receptor interacting protein-like 2	24	0.97
chr2_101752020_101752171	0.46	Prr5l	proline rich 5 like	45555	0.14
chr11_85832197_85833021	0.45	Tbx2	T-box 2	58	0.84
chr9_18473066_18474201	0.42	Zfp558	zinc finger protein 558	74	0.95
chr19_43957421_43957601	0.42	Cpn1	carboxypeptidase N, polypeptide 1	11182	0.13
chr19_5094164_5095202	0.42	Cnih2	cornichon family AMPA receptor auxiliary protein 2	3699	0.08
chr19_38026271_38026463	0.41	Myof	myoferlin	16984	0.15
chr8_121786646_121786834	0.41	Klhdc4	kelch domain containing 4	10688	0.12
chr10_80948620_80948940	0.41	Gm3828	predicted gene 3828	5930	0.1
chr17_25433917_25434633	0.40	Cacna1h	calcium channel, voltage-dependent, T type, alpha 1H subunit	492	0.69
chr2_127415922_127416073	0.39	Gpat2	glycerol-3-phosphate acyltransferase 2, mitochondrial	9202	0.15
chr1_191184878_191185214	0.38	Atf3	activating transcription factor 3	1706	0.28
chr1_85617918_85618139	0.38	Gm10552	predicted gene 10552	6132	0.1
chr7_63816080_63816231	0.38	Gm7482	predicted gene 7482	4825	0.18
chr12_84408114_84409175	0.37	Entpd5	ectonucleoside triphosphate diphosphohydrolase 5	340	0.53
chr12_86882228_86883612	0.37	Irf2bpl	interferon regulatory factor 2 binding protein-like	1878	0.33
chr15_8279549_8279700	0.37	Cplane1	ciliogenesis and planar polarity effector 1	32521	0.18
chr11_74896307_74898160	0.36	Sgsm2	small G protein signaling modulator 2	173	0.84
chr2_26604241_26604792	0.35	Agpat2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	99	0.92
chr7_142561215_142561756	0.35	Nctc1	non-coding transcript 1	2889	0.14
chr17_75014632_75015003	0.35	Ltbp1	latent transforming growth factor beta binding protein 1	8523	0.24
chr16_38362984_38363227	0.35	Popdc2	popeye domain containing 2	860	0.48
chr2_26503184_26504033	0.35	Notch1	notch 1	214	0.89
chr2_138256185_138257474	0.34	Btbd3	BTB (POZ) domain containing 3	159	0.98
chr3_96451263_96451652	0.34	BC107364	cDNA sequence BC107364	849	0.24
chr2_74732641_74732796	0.34	Hoxd3	homeobox D3	195	0.81
chr7_99351180_99351446	0.34	Serpinh1	serine (or cysteine) peptidase inhibitor, clade H, member 1	1684	0.3
chr10_86300212_86300618	0.34	Timp3	tissue inhibitor of metalloproteinase 3	43	0.98
chr3_8717321_8717847	0.34	C230057A21Rik	RIKEN cDNA C230057A21 gene	18616	0.14
chr14_27114666_27114961	0.34	Arhgef3	Rho guanine nucleotide exchange factor (GEF) 3	86	0.98
chr11_81612309_81613487	0.33	Gm11418	predicted gene 11418	25537	0.22
chr9_32901255_32901639	0.33	Gm27162	predicted gene 27162	27519	0.18
chr1_39721483_39721634	0.33	Rfx8	regulatory factor X 8	561	0.78
chr10_103001022_103001290	0.33	Alx1	ALX homeobox 1	21418	0.19
chr5_128598799_128598977	0.33	Gm42498	predicted gene 42498	932	0.43
chr7_100911356_100911541	0.32	Arhgef17	Rho guanine nucleotide exchange factor (GEF) 17	16758	0.13
chr15_66961775_66961932	0.32	Ndrg1	N-myc downstream regulated gene 1	6072	0.18
chr10_121475538_121476618	0.32	Rassf3	Ras association (RalGDS/AF-6) domain family member 3	269	0.86
chr5_125264626_125264993	0.32	Gm32585	predicted gene, 32585	8006	0.18
chr5_107195880_107196420	0.32	Tgfbr3	transforming growth factor, beta receptor III	3783	0.2
chr7_110982411_110982739	0.32	Mrvi1	MRV integration site 1	114	0.97
chr8_11476357_11476528	0.31	E230013L22Rik	RIKEN cDNA E230013L22 gene	1487	0.25
chr2_72614373_72614524	0.31	Pex13-ps	peroxisomal biogenesis factor 13, pseudogene	17822	0.16
chr1_88213749_88214214	0.31	Ugt1a1	UDP glucuronosyltransferase 1 family, polypeptide A1	2022	0.13
chr14_27823142_27823309	0.31	Erc2	ELKS/RAB6-interacting/CAST family member 2	24667	0.22
chr8_15027100_15028701	0.31	Gm37844	predicted gene, 37844	522	0.44
chr9_50752051_50752676	0.30	Hspb2	heat shock protein 2	9	0.88
chr5_43232754_43234178	0.30	Cpeb2	cytoplasmic polyadenylation element binding protein 2	296	0.85
chr1_132346162_132346444	0.30	F730311O21Rik	RIKEN cDNA F730311O21 gene	4280	0.14
chr13_35740610_35741587	0.30	Cdyl	chromodomain protein, Y chromosome-like	215	0.94
chr4_135876235_135877013	0.30	Pnrc2	proline-rich nuclear receptor coactivator 2	2774	0.15
chr13_41605449_41606727	0.29	Tmem170b	transmembrane protein 170B	128	0.96
chr17_26414662_26415402	0.29	Neurl1b	neuralized E3 ubiquitin protein ligase 1B	67	0.97
chr4_149954471_149955779	0.29	Spsb1	splA/ryanodine receptor domain and SOCS box containing 1	82	0.97
chr6_63257322_63257806	0.29	9330118I20Rik	RIKEN cDNA 9330118I20 gene	61	0.93
chr8_69995796_69997172	0.27	Gatad2a	GATA zinc finger domain containing 2A	100	0.95
chr7_45588766_45589660	0.27	Bcat2	branched chain aminotransferase 2, mitochondrial	3792	0.07
chr5_140606846_140607467	0.27	Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	164	0.83
chr15_81585272_81586453	0.27	Gm23880	predicted gene, 23880	271	0.52
chr5_53998183_53999428	0.27	Stim2	stromal interaction molecule 2	240	0.95
chr1_89538633_89538887	0.27	Gm25180	predicted gene, 25180	24600	0.16
chr5_147758193_147758351	0.27	Gm43156	predicted gene 43156	12756	0.19
chr1_72945188_72945345	0.27	1700027A15Rik	RIKEN cDNA 1700027A15 gene	39578	0.16
chr2_26595840_26596165	0.27	Egfl7	EGF-like domain 7	3855	0.1
chr13_56588245_56589118	0.26	2010203P06Rik	RIKEN cDNA 2010203P06 gene	6856	0.18
chr14_57057660_57057892	0.26	Gja3	gap junction protein, alpha 3	53	0.97
chr9_56994536_56995264	0.26	Ptpn9	protein tyrosine phosphatase, non-receptor type 9	23	0.97
chr14_34560304_34560455	0.26	Ldb3	LIM domain binding 3	16615	0.11
chr16_29977900_29978051	0.26	Gm1968	predicted gene 1968	1209	0.44
chr2_32884809_32884960	0.26	Fam129b	family with sequence similarity 129, member B	8770	0.11
chr11_62789333_62789872	0.26	Zfp286	zinc finger protein 286	140	0.92
chr10_127516477_127517046	0.25	Ndufa4l2	Ndufa4, mitochondrial complex associated like 2	1794	0.18
chr9_108480057_108480354	0.25	Lamb2	laminin, beta 2	324	0.71
chr19_10304418_10305190	0.25	Dagla	diacylglycerol lipase, alpha	53	0.97
chr8_69654078_69655164	0.25	Zfp964	zinc finger protein 964	129	0.95
chr1_189615380_189615531	0.25	Gm38122	predicted gene, 38122	24779	0.18
chr3_105018285_105018436	0.25	Gm40117	predicted gene, 40117	24328	0.13
chr15_76206813_76207932	0.25	Plec	plectin	881	0.36
chr8_122546722_122547355	0.24	Piezo1	piezo-type mechanosensitive ion channel component 1	4291	0.11
chr16_92345192_92345711	0.24	Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	13423	0.11
chr8_71381974_71382671	0.24	Nr2f6	nuclear receptor subfamily 2, group F, member 6	362	0.74
chr7_136406485_136406636	0.24	Gm36849	predicted gene, 36849	53196	0.14
chr4_117985332_117985486	0.23	9530034E10Rik	RIKEN cDNA 9530034E10 gene	10373	0.15
chr5_134742453_134742604	0.23	Gm30003	predicted gene, 30003	4514	0.16
chr11_70608772_70609053	0.23	Mink1	misshapen-like kinase 1 (zebrafish)	826	0.32
chr11_59364469_59364771	0.23	Gm15755	predicted gene 15755	10841	0.12
chr8_24438713_24439074	0.23	Tcim	transcriptional and immune response regulator	91	0.96
chr15_6386264_6386948	0.23	Dab2	disabled 2, mitogen-responsive phosphoprotein	8	0.98
chr17_56672739_56673924	0.23	Ranbp3	RAN binding protein 3	27	0.96
chr7_49527689_49528213	0.22	Nav2	neuron navigator 2	20241	0.23
chr1_60652807_60652958	0.22	Gm23762	predicted gene, 23762	39079	0.1
chr15_83724974_83725683	0.22	Scube1	signal peptide, CUB domain, EGF-like 1	307	0.92
chr17_66448520_66450314	0.22	Mtcl1	microtubule crosslinking factor 1	333	0.57
chr11_30648868_30649937	0.22	Acyp2	acylphosphatase 2, muscle type	185	0.95
chr1_93754379_93755416	0.22	Atg4b	autophagy related 4B, cysteine peptidase	8	0.5
chr6_65670118_65670269	0.22	Ndnf	neuron-derived neurotrophic factor	1397	0.49
chr9_44734596_44735576	0.22	Phldb1	pleckstrin homology like domain, family B, member 1	112	0.91
chr14_47921837_47922130	0.21	4930447J18Rik	RIKEN cDNA 4930447J18 gene	23074	0.15
chr9_60837244_60837770	0.21	Gm9869	predicted gene 9869	692	0.7
chr7_143777485_143777636	0.21	Gm44998	predicted gene 44998	2447	0.15
chr9_35331987_35332138	0.21	Gm33838	predicted gene, 33838	24463	0.11
chr13_43864441_43864954	0.21	Gm33195	predicted gene, 33195	28	0.97
chr4_129928556_129928707	0.21	Spocd1	SPOC domain containing 1	618	0.62
chr10_25359547_25360523	0.21	Epb41l2	erythrocyte membrane protein band 4.1 like 2	179	0.95
chr6_141249885_141250621	0.20	Gm28523	predicted gene 28523	244	0.55
chr11_53904266_53904446	0.20	Gm12218	predicted gene 12218	1201	0.29
chr2_145787427_145787839	0.20	Rin2	Ras and Rab interactor 2	1471	0.48
chr9_41889978_41890642	0.20	Gm40513	predicted gene, 40513	294	0.89
chr2_27212365_27212516	0.20	Sardh	sarcosine dehydrogenase	2503	0.21
chr12_32378513_32379490	0.20	Ccdc71l	coiled-coil domain containing 71 like	297	0.93
chr3_146117348_146117511	0.20	Mcoln3	mucolipin 3	21	0.96
chr3_99183530_99183681	0.20	Gm18982	predicted gene, 18982	2324	0.2
chr2_26491019_26491170	0.19	Notch1	notch 1	12728	0.1
chr8_94377668_94378018	0.19	Gm15889	predicted gene 15889	29	0.95
chr7_99626901_99627081	0.19	Tpbgl	trophoblast glycoprotein-like	112	0.9
chr10_13473756_13474638	0.19	Phactr2	phosphatase and actin regulator 2	215	0.94
chr5_112166735_112167033	0.19	1700016B01Rik	RIKEN cDNA 1700016B01 gene	10647	0.17
chr1_88701358_88702305	0.19	Arl4c	ADP-ribosylation factor-like 4C	45	0.97
chr9_70243232_70243383	0.19	Myo1e	myosin IE	35939	0.17
chr4_149999267_149999418	0.19	H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	1923	0.28
chr11_107547352_107548463	0.19	Helz	helicase with zinc finger domain	23	0.88
chr19_5567497_5568487	0.19	Ap5b1	adaptor-related protein complex 5, beta 1 subunit	33	0.93
chr13_31798221_31798372	0.18	Gm11379	predicted gene 11379	757	0.63
chr7_31115171_31115481	0.18	Hpn	hepsin	36	0.95
chr8_120804879_120805047	0.18	Irf8	interferon regulatory factor 8	52754	0.1
chr4_142077883_142078172	0.18	Tmem51os1	Tmem51 opposite strand 1	5945	0.15
chr4_120144444_120144645	0.18	Edn2	endothelin 2	16662	0.22
chr11_103244905_103245215	0.17	Map3k14	mitogen-activated protein kinase kinase kinase 14	2789	0.17
chr7_66427385_66427727	0.17	Aldh1a3	aldehyde dehydrogenase family 1, subfamily A3	39	0.97
chrY_90771840_90772811	0.17	Gm47283	predicted gene, 47283	12413	0.17
chr17_31686321_31686544	0.17	Gm50222	predicted gene, 50222	2058	0.19
chr5_99375821_99375972	0.17	Gm35394	predicted gene, 35394	101801	0.07
chr5_106801577_106801728	0.17	Gm8365	predicted gene 8365	62888	0.09
chr8_13695607_13695765	0.17	Cfap97d2	CFAP97 domain containing 2	10203	0.16
chr17_71782235_71783145	0.17	Clip4	CAP-GLY domain containing linker protein family, member 4	73	0.97
chr10_79866106_79866295	0.17	Plppr3	phospholipid phosphatase related 3	1081	0.19
chr5_33695613_33695860	0.17	Gm42965	predicted gene 42965	12762	0.1
chr11_75462938_75463374	0.17	Mir22	microRNA 22	560	0.47
chr5_111532860_111533036	0.17	C130026L21Rik	RIKEN cDNA C130026L21 gene	48474	0.13
chr19_5414445_5414596	0.17	Gm6293	predicted pseudogene 6293	1239	0.16
chr13_106936192_106937354	0.17	Ipo11	importin 11	172	0.93
chr15_76465093_76465561	0.17	Scx	scleraxis	7807	0.08
chr10_42614130_42614512	0.16	Ostm1	osteopetrosis associated transmembrane protein 1	30483	0.16
chr1_182090368_182090591	0.16	Gm37177	predicted gene, 37177	19076	0.14
chr1_184731813_184732486	0.16	Hlx	H2.0-like homeobox	470	0.75
chr4_133680182_133680333	0.16	Pigv	phosphatidylinositol glycan anchor biosynthesis, class V	7610	0.13
chr1_33488501_33488652	0.16	Gm29228	predicted gene 29228	6475	0.23
chr2_152734500_152735322	0.16	Id1	inhibitor of DNA binding 1, HLH protein	1340	0.29
chr6_72235086_72235414	0.16	Atoh8	atonal bHLH transcription factor 8	20	0.97
chr1_31017458_31017792	0.16	4931428L18Rik	RIKEN cDNA 4931428L18 gene	17721	0.14
chr11_86993066_86994378	0.16	Ypel2	yippee like 2	15	0.97
chr7_6382694_6383817	0.16	Zfp28	zinc finger protein 28	40	0.94
chr3_100462225_100462649	0.16	Gm43121	predicted gene 43121	24603	0.11
chr11_97415706_97416357	0.15	Arhgap23	Rho GTPase activating protein 23	498	0.76
chr10_62792164_62792669	0.15	Ccar1	cell division cycle and apoptosis regulator 1	130	0.93
chr15_102105460_102106270	0.15	Tns2	tensin 2	753	0.51
chr11_119807843_119807994	0.15	Rptor	regulatory associated protein of MTOR, complex 1	3328	0.23
chr19_43440308_43441144	0.15	Gm47936	predicted gene, 47936	266	0.5
chr6_97311994_97312190	0.15	Frmd4b	FERM domain containing 4B	288	0.93
chr18_61056422_61056649	0.15	Pdgfrb	platelet derived growth factor receptor, beta polypeptide	11335	0.13
chr2_148044552_148044703	0.15	Foxa2	forkhead box A2	837	0.56
chr9_107908926_107909153	0.15	Mst1r	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	2132	0.13
chr8_102786860_102787011	0.15	Cdh11	cadherin 11	1293	0.45
chr2_91656850_91657112	0.15	Arhgap1	Rho GTPase activating protein 1	3773	0.13
chr7_28277569_28278227	0.14	Eid2b	EP300 interacting inhibitor of differentiation 2B	159	0.89
chr17_10093886_10094100	0.14	Qk	quaking	119581	0.06
chr10_80656363_80657283	0.14	Btbd2	BTB (POZ) domain containing 2	248	0.82
chr2_75997808_75997959	0.14	Pde11a	phosphodiesterase 11A	8160	0.17
chr7_130865550_130866588	0.14	Plekha1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	159	0.63
chr12_86974721_86975193	0.14	Zdhhc22	zinc finger, DHHC-type containing 22	8878	0.15
chr18_76035512_76035730	0.14	1700003O11Rik	RIKEN cDNA 1700003O11 gene	19944	0.19
chr11_106036361_106037705	0.14	Dcaf7	DDB1 and CUL4 associated factor 7	133	0.92
chr7_133047426_133047577	0.14	Ctbp2	C-terminal binding protein 2	17385	0.17
chr11_33871976_33872356	0.14	Kcnip1	Kv channel-interacting protein 1	28581	0.21
chr9_48835918_48836556	0.13	Zbtb16	zinc finger and BTB domain containing 16	15	0.98
chr15_103366694_103366859	0.13	Itga5	integrin alpha 5 (fibronectin receptor alpha)	13	0.96
chr15_103169326_103169551	0.13	Smug1	single-strand selective monofunctional uracil DNA glycosylase	2346	0.18
chr15_86202694_86203051	0.13	Gm22818	predicted gene, 22818	9785	0.16
chr2_153256681_153256832	0.13	Pofut1	protein O-fucosyltransferase 1	726	0.59
chr7_97737443_97738488	0.13	Aqp11	aquaporin 11	27	0.97
chr17_47842318_47842529	0.13	Gm25201	predicted gene, 25201	1438	0.29

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Arnt2

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0007386	compartment pattern specification(GO:0007386)
0.1	0.4	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1	0.5	GO:0048550	negative regulation of pinocytosis(GO:0048550)
0.1	0.3	GO:0034499	late endosome to Golgi transport(GO:0034499)
0.1	0.4	GO:0060596	mammary placode formation(GO:0060596)
0.1	0.3	GO:0007525	somatic muscle development(GO:0007525)
0.1	0.2	GO:0060931	sinoatrial node cell development(GO:0060931)
0.1	0.2	GO:0038171	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.1	0.2	GO:2000857	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1	0.3	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.1	0.3	GO:0070086	ubiquitin-dependent endocytosis(GO:0070086)
0.1	0.3	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.1	0.5	GO:0007262	STAT protein import into nucleus(GO:0007262)
0.1	0.2	GO:0048677	axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1	0.2	GO:2000611	positive regulation of thyroid hormone generation(GO:2000611)
0.1	0.2	GO:0060166	olfactory pit development(GO:0060166)
0.1	0.1	GO:0021563	glossopharyngeal nerve development(GO:0021563)
0.1	0.4	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.1	0.3	GO:0032237	activation of store-operated calcium channel activity(GO:0032237)
0.0	0.3	GO:0060087	relaxation of vascular smooth muscle(GO:0060087)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.5	GO:0002329	pre-B cell differentiation(GO:0002329)
0.0	0.3	GO:0034651	cortisol biosynthetic process(GO:0034651)
0.0	0.2	GO:2001197	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0	0.6	GO:0014051	gamma-aminobutyric acid secretion(GO:0014051)
0.0	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.1	GO:2000574	regulation of microtubule motor activity(GO:2000574)
0.0	0.1	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0	0.0	GO:0032532	regulation of microvillus length(GO:0032532)
0.0	0.1	GO:0090158	endoplasmic reticulum membrane organization(GO:0090158)
0.0	0.1	GO:0009732	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.1	GO:0051697	protein delipidation(GO:0051697)
0.0	0.3	GO:0010172	embryonic body morphogenesis(GO:0010172)
0.0	0.1	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	0.1	GO:0003433	chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.0	0.1	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	0.1	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.0	0.1	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.0	0.1	GO:2000383	regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0032049	cardiolipin biosynthetic process(GO:0032049)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0060282	positive regulation of oocyte development(GO:0060282)
0.0	0.1	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0045629	negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0	0.1	GO:0060154	cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0	0.1	GO:0051138	regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.1	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.0	GO:0046061	dATP catabolic process(GO:0046061)
0.0	0.2	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.2	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.0	0.2	GO:0050961	detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0	0.0	GO:0043096	purine nucleobase salvage(GO:0043096)
0.0	0.2	GO:0045821	positive regulation of glycolytic process(GO:0045821)
0.0	0.1	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.0	0.1	GO:0072015	glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0	0.0	GO:0035993	deltoid tuberosity development(GO:0035993)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.0	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.1	GO:1900246	positive regulation of RIG-I signaling pathway(GO:1900246)
0.0	0.1	GO:0046543	development of secondary female sexual characteristics(GO:0046543)
0.0	0.1	GO:0060406	positive regulation of penile erection(GO:0060406)
0.0	0.1	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0	0.0	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.0	GO:0018879	biphenyl metabolic process(GO:0018879)
0.0	0.1	GO:0038030	non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0	0.2	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.2	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.0	GO:0014826	vein smooth muscle contraction(GO:0014826)
0.0	0.0	GO:0014734	skeletal muscle hypertrophy(GO:0014734)
0.0	0.0	GO:2000546	positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0	0.1	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0	0.1	GO:0071225	cellular response to muramyl dipeptide(GO:0071225)
0.0	0.1	GO:1904970	brush border assembly(GO:1904970)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0080154	regulation of fertilization(GO:0080154)
0.0	0.1	GO:0097264	self proteolysis(GO:0097264)
0.0	0.0	GO:0032066	nucleolus to nucleoplasm transport(GO:0032066)
0.0	0.0	GO:0043622	cortical microtubule organization(GO:0043622)
0.0	0.0	GO:2000491	positive regulation of hepatic stellate cell activation(GO:2000491)
0.0	0.0	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.3	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1	0.2	GO:0005608	laminin-3 complex(GO:0005608)
0.0	0.1	GO:0097427	microtubule bundle(GO:0097427)
0.0	0.2	GO:0045180	basal cortex(GO:0045180)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.2	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.1	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.2	GO:0030132	clathrin coat of coated pit(GO:0030132)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.0	GO:0070552	BRISC complex(GO:0070552)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.8	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.3	GO:0005922	connexon complex(GO:0005922)
0.0	0.2	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.2	GO:0043196	varicosity(GO:0043196)
0.0	0.0	GO:0071953	elastic fiber(GO:0071953)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.1	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0	0.9	GO:0005901	caveola(GO:0005901)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0034191	apolipoprotein A-I receptor binding(GO:0034191)
0.1	0.3	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.1	0.6	GO:0038132	neuregulin binding(GO:0038132)
0.1	0.2	GO:0045134	uridine-diphosphatase activity(GO:0045134)
0.1	0.2	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1	0.2	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.2	GO:0042731	PH domain binding(GO:0042731)
0.0	0.3	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0	0.1	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:2001069	glycogen binding(GO:2001069)
0.0	0.2	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.2	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0030572	cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.0	0.5	GO:0005112	Notch binding(GO:0005112)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.3	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0034618	arginine binding(GO:0034618)
0.0	0.1	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.1	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0	0.6	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.3	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.1	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0	0.1	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.1	GO:0051434	BH3 domain binding(GO:0051434)
0.0	0.1	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0	0.3	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.0	GO:0008732	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0	0.2	GO:0070008	serine-type exopeptidase activity(GO:0070008)
0.0	0.0	GO:0031708	endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.0	GO:0001031	RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084)
0.0	1.4	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	0.0	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.0	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.1	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.2	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.4	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.4	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.4	REACTOME GAP JUNCTION TRAFFICKING	Genes involved in Gap junction trafficking
0.2	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.7	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors