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ENCODE: ATAC-seq of different tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Batf3

Z-value: 0.62

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Transcription factors associated with Batf3

Gene Symbol	Gene ID	Gene Info
Batf3 Ensembl NCBI MGI UniProt	ENSMUSG00000026630.4	Batf3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Batf3	chr1_191097955_191098106	150	0.924944	-0.28	3.9e-02	Click!
Batf3	chr1_191098208_191098740	91	0.947370	-0.23	8.9e-02	Click!
Batf3	chr1_191111292_191111443	10890	0.113908	-0.14	3.0e-01	Click!

Activity of the Batf3 motif across conditions

Conditions sorted by the z-value of the Batf3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_69709128_69709981	4.91	Rpl32-ps	ribosomal protein L32, pseudogene	7839	0.17
chr1_165396068_165396234	3.55	Dcaf6	DDB1 and CUL4 associated factor 6	7390	0.14
chr2_49730225_49730511	1.99	Kif5c	kinesin family member 5C	2243	0.36
chr3_17793443_17793892	1.96	Mir124-2hg	Mir124-2 host gene (non-protein coding)	253	0.9
chr7_142088957_142089418	1.92	Dusp8	dual specificity phosphatase 8	6085	0.08
chr17_72399498_72399651	1.76	Gm24736	predicted gene, 24736	99844	0.07
chr6_124464616_124464917	1.75	Clstn3	calsyntenin 3	28	0.95
chr1_38446167_38446442	1.74	Gm34727	predicted gene, 34727	41215	0.16
chr3_129536267_129536526	1.72	Gm43072	predicted gene 43072	1745	0.29
chr8_70500802_70501205	1.68	Crlf1	cytokine receptor-like factor 1	130	0.9
chr14_68048454_68048605	1.67	Gm31107	predicted gene, 31107	2801	0.28
chr12_73286641_73287386	1.64	Slc38a6	solute carrier family 38, member 6	47	0.81
chr14_87140676_87141090	1.61	Diaph3	diaphanous related formin 3	260	0.93
chr6_57703265_57703437	1.60	Lancl2	LanC (bacterial lantibiotic synthetase component C)-like 2	264	0.88
chr7_141146101_141146426	1.60	Ptdss2	phosphatidylserine synthase 2	8360	0.08
chr13_65258166_65258818	1.59	Gm10775	predicted gene 10775	1047	0.28
chr8_60954723_60954914	1.55	Clcn3	chloride channel, voltage-sensitive 3	39	0.97
chr13_22042530_22043117	1.54	H2ac11	H2A clustered histone 11	121	0.56
chr6_114659319_114659576	1.47	Atg7	autophagy related 7	1383	0.51
chr7_97749679_97749846	1.46	Aqp11	aquaporin 11	11473	0.16
chr4_142017787_142018051	1.42	4930455G09Rik	RIKEN cDNA 4930455G09 gene	21	0.96
chr14_74972805_74972992	1.42	Gm4278	predicted gene 4278	2188	0.3
chr7_128414880_128415076	1.40	Gm15503	predicted gene 15503	2637	0.17
chr2_151563228_151563425	1.37	Sdcbp2	syndecan binding protein (syntenin) 2	9296	0.13
chr11_103101909_103102424	1.37	Acbd4	acyl-Coenzyme A binding domain containing 4	440	0.48
chrY_90771156_90771656	1.35	Gm47283	predicted gene, 47283	13332	0.16
chr14_61680824_61681965	1.35	Gm37472	predicted gene, 37472	100	0.9
chrX_169996827_169997318	1.34	Gm15247	predicted gene 15247	10133	0.15
chr1_82836684_82836853	1.30	Gm22396	predicted gene, 22396	2678	0.14
chr9_111534874_111535371	1.30	Gm42523	predicted gene 42523	13818	0.19
chr3_96905206_96905674	1.28	Gpr89	G protein-coupled receptor 89	94	0.91
chr12_3237774_3237992	1.26	Rab10os	RAB10, member RAS oncogene family, opposite strand	1272	0.39
chr17_55892287_55892468	1.21	Zfp959	zinc finger protein 959	91	0.95
chr15_27871362_27871539	1.18	Gm20555	predicted gene, 20555	4219	0.22
chr17_55878572_55878762	1.18	Zfp119a	zinc finger protein 119a	263	0.86
chr6_120807499_120807674	1.17	Atp6v1e1	ATPase, H+ transporting, lysosomal V1 subunit E1	5164	0.15
chr18_44828099_44828778	1.15	Ythdc2	YTH domain containing 2	692	0.64
chr9_123925253_123925437	1.13	Ccr1	chemokine (C-C motif) receptor 1	43347	0.1
chr1_132322162_132322332	1.13	Nuak2	NUAK family, SNF1-like kinase, 2	5349	0.13
chr1_179433930_179434100	1.12	Smyd3	SET and MYND domain containing 3	28596	0.2
chr12_3238767_3239202	1.11	Rab10os	RAB10, member RAS oncogene family, opposite strand	2373	0.24
chr10_63122610_63122870	1.11	Mypn	myopalladin	56	0.96
chr3_17592524_17592749	1.10	Gm38154	predicted gene, 38154	78052	0.11
chr2_129227265_129227416	1.10	A730036I17Rik	RIKEN cDNA A730036I17 gene	682	0.4
chr6_115666689_115667030	1.10	Raf1	v-raf-leukemia viral oncogene 1	9105	0.12
chr13_23760830_23761749	1.09	H4c1	H4 clustered histone 1	59	0.86
chr8_79711585_79712295	1.07	Anapc10	anaphase promoting complex subunit 10	89	0.65
chr16_75837887_75838038	1.05	Gm15554	predicted gene 15554	64905	0.09
chr8_77548898_77549532	1.05	Prmt9	protein arginine methyltransferase 9	182	0.92
chr1_184851887_184852286	1.04	Mtarc2	mitochondrial amidoxime reducing component 2	5635	0.17
chr2_59351695_59352106	1.04	Pkp4	plakophilin 4	9703	0.19
chr7_118463178_118463349	1.03	Syt17	synaptotagmin XVII	15041	0.15
chr11_88242035_88242186	1.03	Gm38534	predicted gene, 38534	11258	0.17
chr3_94484140_94484361	1.02	Celf3	CUGBP, Elav-like family member 3	77	0.93
chr2_109280292_109280860	1.01	Mettl15	methyltransferase like 15	126	0.55
chr16_10976223_10976631	1.00	Litaf	LPS-induced TN factor	848	0.46
chr6_128799495_128800104	1.00	Klrb1c	killer cell lectin-like receptor subfamily B member 1C	10584	0.1
chr1_75214435_75214934	0.98	Stk16	serine/threonine kinase 16	1623	0.13
chr6_57822566_57822717	0.97	Vopp1	vesicular, overexpressed in cancer, prosurvival protein 1	1999	0.23
chr12_84217180_84217402	0.96	Gm47447	predicted gene, 47447	1154	0.3
chr2_127444443_127444898	0.96	Fahd2a	fumarylacetoacetate hydrolase domain containing 2A	105	0.96
chr9_103234179_103234348	0.95	Trf	transferrin	3819	0.2
chr3_82478392_82478716	0.95	Npy2r	neuropeptide Y receptor Y2	69406	0.11
chr7_97788183_97788962	0.94	Pak1	p21 (RAC1) activated kinase 1	31	0.98
chr12_100167000_100167151	0.93	Nrde2	nrde-2 necessary for RNA interference, domain containing	7422	0.14
chr17_55944886_55945074	0.93	Zfp119b	zinc finger protein 119b	279	0.8
chr8_66860040_66861058	0.90	Naf1	nuclear assembly factor 1 ribonucleoprotein	332	0.88
chr9_7836413_7837486	0.90	Birc2	baculoviral IAP repeat-containing 2	108	0.96
chr13_21935906_21936057	0.90	Zfp184	zinc finger protein 184 (Kruppel-like)	9113	0.06
chrX_13070554_13071574	0.90	Usp9x	ubiquitin specific peptidase 9, X chromosome	434	0.84
chr10_108333682_108333833	0.89	Pawr	PRKC, apoptosis, WT1, regulator	940	0.6
chr6_86669349_86669907	0.88	Mxd1	MAX dimerization protein 1	467	0.68
chr18_10939016_10939167	0.88	Gm7575	predicted gene 7575	10207	0.23
chr18_9957690_9958213	0.88	Thoc1	THO complex 1	45	0.97
chr11_4250427_4250602	0.87	Lif	leukemia inhibitory factor	7043	0.1
chr13_113168382_113168574	0.87	Gzmk	granzyme K	12419	0.12
chr7_80324088_80324301	0.85	Rccd1	RCC1 domain containing 1	41	0.95
chr16_57606439_57606962	0.84	Cmss1	cms small ribosomal subunit 1	76	0.98
chr7_138846157_138846363	0.84	Mapk1ip1	mitogen-activated protein kinase 1 interacting protein 1	0	0.58
chr4_63374024_63374199	0.84	Akna	AT-hook transcription factor	7092	0.11
chr2_93096177_93096364	0.83	Gm13802	predicted gene 13802	1974	0.37
chr9_69467648_69467967	0.82	Anxa2	annexin A2	10658	0.12
chr7_16296088_16297248	0.82	Ccdc9	coiled-coil domain containing 9	9873	0.11
chr9_64178981_64179377	0.81	Snapc5	small nuclear RNA activating complex, polypeptide 5	95	0.89
chr6_35173300_35173451	0.79	Nup205	nucleoporin 205	4046	0.24
chr11_20200843_20201200	0.79	Rab1a	RAB1A, member RAS oncogene family	411	0.82
chr3_40799878_40800077	0.79	Plk4	polo like kinase 4	42	0.96
chr17_88113373_88113524	0.78	Gm4832	predicted gene 4832	12064	0.18
chr17_28013289_28013809	0.77	Anks1	ankyrin repeat and SAM domain containing 1	6204	0.13
chr1_92473261_92473440	0.77	Ndufa10	NADH:ubiquinone oxidoreductase subunit A10	397	0.76
chr17_53596429_53596797	0.76	Gm6919	predicted gene 6919	2050	0.27
chr4_63389695_63390110	0.75	Aknaos	AT-hook transcription factor, opposite strand	8544	0.12
chr4_116175694_116176193	0.75	Gm12951	predicted gene 12951	303	0.78
chr8_4779223_4779832	0.74	Shcbp1	Shc SH2-domain binding protein 1	24	0.95
chr3_105483711_105484059	0.74	Gm43847	predicted gene 43847	19022	0.17
chr2_129242545_129242834	0.74	Gm14024	predicted gene 14024	3687	0.12
chr7_16399506_16399684	0.74	Zc3h4	zinc finger CCCH-type containing 4	1315	0.27
chr14_30876254_30876405	0.74	Mustn1	musculoskeletal, embryonic nuclear protein 1	2871	0.16
chrX_56597885_56598283	0.73	Mmgt1	membrane magnesium transporter 1	15	0.97
chr5_130706297_130706454	0.73	Gm23761	predicted gene, 23761	76326	0.1
chr1_161766742_161767051	0.73	Gm5049	predicted gene 5049	20840	0.12
chr2_120609238_120609778	0.73	Lrrc57	leucine rich repeat containing 57	0	0.56
chr19_61227192_61227555	0.73	Csf2ra	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	3	0.96
chr1_75168558_75168746	0.73	Zfand2b	zinc finger, AN1 type domain 2B	3	0.93
chr11_121086446_121086616	0.72	Sectm1a	secreted and transmembrane 1A	5311	0.09
chr19_24961254_24961969	0.72	Cbwd1	COBW domain containing 1	1	0.97
chr18_12786714_12786865	0.71	Osbpl1a	oxysterol binding protein-like 1A	19652	0.15
chr7_99795341_99796009	0.71	F730035P03Rik	RIKEN cDNA F730035P03 gene	14136	0.11
chr6_49263929_49264218	0.71	Tra2a	transformer 2 alpha	40	0.97
chr3_34231745_34231896	0.70	Sox2ot	SOX2 overlapping transcript (non-protein coding)	34956	0.16
chr10_59777356_59777560	0.70	Micu1	mitochondrial calcium uptake 1	15045	0.14
chr13_67360105_67360768	0.70	Gm28044	predicted gene, 28044	100	0.47
chr13_97775152_97775346	0.69	Rps18-ps6	ribosomal protein S18, pseudogene 6	14617	0.14
chr1_92473653_92474522	0.69	Ndufa10	NADH:ubiquinone oxidoreductase subunit A10	227	0.88
chr12_75307963_75308582	0.69	Rhoj	ras homolog family member J	50	0.99
chr7_7298676_7299288	0.69	Mir5620	microRNA 5620	91	0.61
chr5_123854595_123854839	0.68	Hcar2	hydroxycarboxylic acid receptor 2	10782	0.13
chr10_111073345_111073645	0.68	Gm48851	predicted gene, 48851	29376	0.14
chr4_41708277_41708428	0.68	Rpp25l	ribonuclease P/MRP 25 subunit-like	5182	0.1
chr8_84256509_84256688	0.68	Mri1	methylthioribose-1-phosphate isomerase 1	185	0.87
chr10_82240724_82241110	0.67	Zfp938	zinc finger protein 938	356	0.84
chr16_38562668_38563355	0.66	Tmem39a	transmembrane protein 39a	125	0.95
chr9_71976147_71976576	0.66	Gm37663	predicted gene, 37663	14910	0.1
chr9_14246488_14246694	0.66	Gm47565	predicted gene, 47565	4348	0.18
chr7_135813684_135813871	0.66	6330420H09Rik	RIKEN cDNA 6330420H09 gene	39905	0.12
chr5_89763970_89764289	0.66	Gm25758	predicted gene, 25758	64742	0.13
chr2_20944134_20944558	0.66	Arhgap21	Rho GTPase activating protein 21	927	0.58
chr2_69722689_69722921	0.66	Ppig	peptidyl-prolyl isomerase G (cyclophilin G)	0	0.96
chr5_24383104_24384088	0.66	Gm15587	predicted gene 15587	14	0.94
chr15_13171596_13171768	0.66	Cdh6	cadherin 6	1993	0.47
chrX_101290140_101290457	0.65	Med12	mediator complex subunit 12	2836	0.13
chr1_161036007_161036172	0.65	Gm22357	predicted gene, 22357	32	0.41
chr11_29607584_29607776	0.65	Gm12091	predicted gene 12091	5067	0.14
chr4_154603637_154604075	0.64	Gm13134	predicted gene 13134	2541	0.22
chr17_57098452_57098603	0.63	Tnfsf9	tumor necrosis factor (ligand) superfamily, member 9	6798	0.08
chr12_86883989_86885134	0.63	Irf2bpl	interferon regulatory factor 2 binding protein-like	237	0.93
chr2_180892991_180893395	0.63	Mir124a-3	microRNA 124a-3	847	0.31
chr2_122380827_122380978	0.63	Gm24409	predicted gene, 24409	4738	0.15
chr9_106170484_106171031	0.62	Wdr82	WD repeat domain containing 82	171	0.89
chr2_15054565_15055405	0.62	Nsun6	NOL1/NOP2/Sun domain family member 6	84	0.72
chr6_21949203_21949798	0.61	Ing3	inhibitor of growth family, member 3	71	0.98
chr7_7299356_7299778	0.61	Clcn4	chloride channel, voltage-sensitive 4	10	0.91
chr7_4149205_4149990	0.61	Leng9	leukocyte receptor cluster (LRC) member 9	777	0.41
chr2_125122926_125123420	0.61	Myef2	myelin basic protein expression factor 2, repressor	241	0.89
chr2_112454615_112455124	0.61	Emc7	ER membrane protein complex subunit 7	128	0.94
chr17_84877971_84878140	0.60	Gm49982	predicted gene, 49982	24514	0.14
chr15_7137719_7137966	0.60	Lifr	LIF receptor alpha	2700	0.38
chr2_144343181_144343332	0.60	Ovol2	ovo like zinc finger 2	11110	0.1
chr13_67724281_67724474	0.60	Zfp65	zinc finger protein 65	51	0.92
chr1_134454955_134455620	0.60	Gm37935	predicted gene, 37935	186	0.56
chr6_91440817_91441099	0.60	1810044D09Rik	RIKEN cDNA 1810044D09 gene	29	0.5
chr4_156054432_156054595	0.59	Mir200a	microRNA 200a	472	0.37
chr10_126749213_126749376	0.59	Gm47966	predicted gene, 47966	29900	0.12
chr18_66458401_66458670	0.59	Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	2	0.96
chr8_69625175_69625427	0.59	Zfp868	zinc finger protein 868	244	0.91
chrX_8176094_8176317	0.59	Tbc1d25	TBC1 domain family, member 25	24	0.95
chr1_59237629_59237969	0.58	Als2	alsin Rho guanine nucleotide exchange factor	568	0.74
chr2_120153745_120155075	0.58	Ehd4	EH-domain containing 4	52	0.97
chr1_166409714_166410315	0.57	Pogk	pogo transposable element with KRAB domain	151	0.94
chr16_50046157_50046358	0.57	Gm8824	predicted gene 8824	64816	0.14
chr11_116572806_116573131	0.57	Ube2o	ubiquitin-conjugating enzyme E2O	8479	0.1
chr3_104795762_104796004	0.57	Rhoc	ras homolog family member C	3900	0.11
chr17_63784808_63784959	0.57	Fer	fer (fms/fps related) protein kinase	78179	0.09
chr19_43898677_43898828	0.57	Dnmbp	dynamin binding protein	8061	0.14
chr3_127552930_127553443	0.56	Larp7	La ribonucleoprotein domain family, member 7	11	0.79
chr2_122377386_122377671	0.56	Gm24409	predicted gene, 24409	8112	0.13
chr10_44268190_44268842	0.56	Atg5	autophagy related 5	101	0.97
chr4_46041817_46041999	0.56	Tmod1	tropomodulin 1	2699	0.27
chr19_61228253_61228788	0.55	Csf2ra	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	91	0.95
chr1_137900910_137901218	0.55	Gm4258	predicted gene 4258	2466	0.14
chrX_155216720_155216871	0.55	Sat1	spermidine/spermine N1-acetyl transferase 1	346	0.82
chr1_171375937_171376095	0.54	Nectin4	nectin cell adhesion molecule 4	5661	0.07
chr2_30929577_30930014	0.54	Ptges	prostaglandin E synthase	68	0.96
chr5_32196023_32196194	0.54	Gm9555	predicted gene 9555	10611	0.15
chr18_80151657_80151990	0.53	Adnp2	ADNP homeobox 2	341	0.77
chr13_23530854_23531458	0.53	H4c8	H4 clustered histone 8	106	0.6
chr5_36691557_36691708	0.51	D5Ertd579e	DNA segment, Chr 5, ERATO Doi 579, expressed	4305	0.16
chr5_33018563_33018867	0.51	Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	101	0.96
chrX_16618200_16618385	0.51	Maoa	monoamine oxidase A	1406	0.48
chr10_82354457_82354651	0.51	Gm4924	predicted gene 4924	238	0.92
chr7_27675038_27675234	0.51	Map3k10	mitogen-activated protein kinase kinase kinase 10	538	0.6
chr1_59394147_59394298	0.51	Gm29016	predicted gene 29016	15292	0.18
chr4_89310510_89311260	0.49	Cdkn2b	cyclin dependent kinase inhibitor 2B	154	0.95
chr9_37177686_37177862	0.49	Gm25273	predicted gene, 25273	4780	0.14
chr14_62446475_62446626	0.48	Gucy1b2	guanylate cyclase 1, soluble, beta 2	8243	0.18
chr13_55425993_55426144	0.48	F12	coagulation factor XII (Hageman factor)	711	0.46
chr17_84466117_84466668	0.48	Thada	thyroid adenoma associated	187	0.95
chrX_162902264_162902478	0.47	Ctps2	cytidine 5'-triphosphate synthase 2	200	0.91
chr12_82225804_82226178	0.45	Sipa1l1	signal-induced proliferation-associated 1 like 1	30594	0.19
chr14_77034576_77034752	0.44	Lacc1	laccase domain containing 1	1417	0.39
chr2_153161013_153161878	0.43	Tm9sf4	transmembrane 9 superfamily protein member 4	96	0.96
chr14_50807340_50808013	0.43	Ccnb1ip1	cyclin B1 interacting protein 1	56	0.42
chr11_116657908_116658166	0.43	Prcd	photoreceptor disc component	881	0.36
chr13_83737818_83738360	0.42	Gm33366	predicted gene, 33366	446	0.49
chr10_81602742_81603198	0.42	Tle6	transducin-like enhancer of split 6	1897	0.15
chr1_75210411_75211182	0.42	Glb1l	galactosidase, beta 1-like	17	0.49
chr12_98628022_98628216	0.42	Spata7	spermatogenesis associated 7	38	0.96
chr13_100871561_100871718	0.41	Gm37830	predicted gene, 37830	1141	0.42
chr6_108706138_108706289	0.41	Bhlhe40	basic helix-loop-helix family, member e40	43167	0.12
chrX_104293744_104293895	0.41	Vcp-rs	valosin containing protein, related sequence	54415	0.12

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Batf3

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	1.8	GO:0048388	endosomal lumen acidification(GO:0048388)
0.5	1.4	GO:1901421	positive regulation of response to alcohol(GO:1901421)
0.3	1.7	GO:1902474	positive regulation of protein localization to synapse(GO:1902474)
0.3	1.3	GO:2000619	negative regulation of histone H4-K16 acetylation(GO:2000619)
0.3	0.9	GO:0048290	isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296)
0.3	0.8	GO:0061535	glutamate secretion, neurotransmission(GO:0061535)
0.3	1.5	GO:2000672	negative regulation of motor neuron apoptotic process(GO:2000672)
0.2	0.7	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.2	0.6	GO:0043134	hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.2	0.7	GO:0021698	cerebellar cortex structural organization(GO:0021698)
0.2	0.7	GO:0098535	de novo centriole assembly(GO:0098535)
0.2	0.8	GO:0097343	ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.2	0.8	GO:0006824	cobalt ion transport(GO:0006824)
0.1	0.6	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1	0.4	GO:0046208	spermine catabolic process(GO:0046208)
0.1	0.7	GO:0044829	positive regulation by host of viral genome replication(GO:0044829)
0.1	0.6	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.1	0.4	GO:0051684	maintenance of Golgi location(GO:0051684)
0.1	0.7	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1	0.6	GO:0070475	rRNA base methylation(GO:0070475)
0.1	0.8	GO:0000055	ribosomal large subunit export from nucleus(GO:0000055)
0.1	0.3	GO:0045054	constitutive secretory pathway(GO:0045054)
0.1	0.7	GO:0031145	anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.1	1.2	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1	1.7	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1	0.3	GO:0033693	neurofilament bundle assembly(GO:0033693)
0.1	0.4	GO:1903847	regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1	0.3	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.1	0.5	GO:1901096	regulation of autophagosome maturation(GO:1901096)
0.1	0.2	GO:0048207	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1	0.8	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1	0.2	GO:0002254	kinin cascade(GO:0002254)
0.1	0.2	GO:2000019	negative regulation of male gonad development(GO:2000019)
0.1	0.3	GO:1900864	mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1	0.3	GO:0033753	ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753)
0.1	0.4	GO:1903546	protein localization to photoreceptor outer segment(GO:1903546)
0.1	0.2	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.1	0.2	GO:0070094	positive regulation of glucagon secretion(GO:0070094)
0.1	0.2	GO:2000118	regulation of sodium-dependent phosphate transport(GO:2000118)
0.1	0.4	GO:1902035	positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.1	0.2	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.1	0.5	GO:0035562	negative regulation of chromatin binding(GO:0035562)
0.1	0.2	GO:0042420	dopamine catabolic process(GO:0042420)
0.1	0.4	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.1	0.2	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.1	0.3	GO:0006450	regulation of translational fidelity(GO:0006450)
0.1	0.5	GO:0046543	development of secondary female sexual characteristics(GO:0046543)
0.1	0.2	GO:0035022	positive regulation of Rac protein signal transduction(GO:0035022)
0.1	0.8	GO:1904872	regulation of telomerase RNA localization to Cajal body(GO:1904872) positive regulation of telomerase RNA localization to Cajal body(GO:1904874)
0.1	0.2	GO:1901642	purine nucleoside transmembrane transport(GO:0015860) purine-containing compound transmembrane transport(GO:0072530) nucleoside transmembrane transport(GO:1901642)
0.1	0.2	GO:0097460	ferrous iron import(GO:0070627) ferrous iron import into cell(GO:0097460)
0.1	0.2	GO:0071336	regulation of hair follicle cell proliferation(GO:0071336)
0.1	0.2	GO:0030241	skeletal muscle myosin thick filament assembly(GO:0030241) striated muscle myosin thick filament assembly(GO:0071688)
0.1	0.1	GO:0070100	negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.1	GO:0032513	negative regulation of protein phosphatase type 2B activity(GO:0032513)
0.0	0.1	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.2	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	0.2	GO:0042780	tRNA 3'-end processing(GO:0042780)
0.0	0.6	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.1	GO:0006393	termination of mitochondrial transcription(GO:0006393)
0.0	0.5	GO:0061299	retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0	0.3	GO:0042796	snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0	0.1	GO:0006363	termination of RNA polymerase I transcription(GO:0006363)
0.0	0.1	GO:0097051	establishment of protein localization to endoplasmic reticulum membrane(GO:0097051)
0.0	0.2	GO:0022007	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.4	GO:0050957	equilibrioception(GO:0050957)
0.0	1.1	GO:0051452	intracellular pH reduction(GO:0051452)
0.0	0.1	GO:0010963	regulation of L-arginine import(GO:0010963)
0.0	1.2	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.0	0.4	GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0	0.3	GO:0071243	cellular response to arsenic-containing substance(GO:0071243)
0.0	0.6	GO:0006907	pinocytosis(GO:0006907)
0.0	0.2	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0010360	negative regulation of anion channel activity(GO:0010360)
0.0	0.2	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.0	0.1	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.6	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.0	0.1	GO:2000645	negative regulation of receptor catabolic process(GO:2000645)
0.0	0.1	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0	0.2	GO:0019368	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.5	GO:0042921	glucocorticoid receptor signaling pathway(GO:0042921)
0.0	0.3	GO:0097034	mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0	0.1	GO:0035973	aggrephagy(GO:0035973)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.5	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0	0.1	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.6	GO:0060716	labyrinthine layer blood vessel development(GO:0060716)
0.0	0.5	GO:0046457	prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
0.0	0.1	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	1.0	GO:0045214	sarcomere organization(GO:0045214)
0.0	0.1	GO:0036215	response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0	0.5	GO:0072520	seminiferous tubule development(GO:0072520)
0.0	0.3	GO:0010801	negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0	0.4	GO:1903846	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0090394	negative regulation of excitatory postsynaptic potential(GO:0090394)
0.0	0.5	GO:0021889	olfactory bulb interneuron differentiation(GO:0021889)
0.0	0.1	GO:0035435	phosphate ion transmembrane transport(GO:0035435)
0.0	0.1	GO:0045585	regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.0	0.1	GO:2001170	negative regulation of ATP biosynthetic process(GO:2001170)
0.0	0.0	GO:0044805	lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) late nucleophagy(GO:0044805)
0.0	0.2	GO:0051026	chiasma assembly(GO:0051026)
0.0	0.2	GO:0000059	protein import into nucleus, docking(GO:0000059)
0.0	0.1	GO:0007096	regulation of exit from mitosis(GO:0007096)
0.0	0.1	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0	0.1	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.2	GO:0006266	DNA ligation(GO:0006266)
0.0	0.1	GO:0042998	positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.0	0.1	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.0	0.1	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.2	GO:2000780	negative regulation of double-strand break repair(GO:2000780)
0.0	0.1	GO:0002318	myeloid progenitor cell differentiation(GO:0002318)
0.0	0.0	GO:0070350	white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.0	0.0	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0	0.0	GO:0035513	oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0	0.1	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:0000393	spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.0	0.0	GO:0071672	negative regulation of smooth muscle cell chemotaxis(GO:0071672)
0.0	0.7	GO:1902476	chloride transmembrane transport(GO:1902476)
0.0	0.1	GO:0002159	desmosome assembly(GO:0002159)
0.0	0.2	GO:0090026	positive regulation of monocyte chemotaxis(GO:0090026)
0.0	0.0	GO:0048850	hypophysis morphogenesis(GO:0048850)
0.0	0.3	GO:0071549	response to dexamethasone(GO:0071548) cellular response to dexamethasone stimulus(GO:0071549)
0.0	0.1	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0	0.1	GO:1902570	protein localization to nucleolus(GO:1902570) regulation of protein localization to nucleolus(GO:1904749) positive regulation of protein localization to nucleolus(GO:1904751)
0.0	0.5	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.5	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.4	GO:0006221	pyrimidine nucleotide biosynthetic process(GO:0006221)
0.0	0.2	GO:0007213	G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0	0.1	GO:0002091	negative regulation of receptor internalization(GO:0002091)
0.0	0.1	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
0.0	0.1	GO:0045040	protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.1	GO:2001135	regulation of endocytic recycling(GO:2001135)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.1	GO:1901409	regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0	0.0	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.0	0.1	GO:0090245	axis elongation involved in somitogenesis(GO:0090245)
0.0	0.0	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.3	GO:0046325	negative regulation of glucose import(GO:0046325)
0.0	0.0	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0042256	mature ribosome assembly(GO:0042256)
0.0	0.6	GO:0006953	acute-phase response(GO:0006953)
0.0	0.0	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.1	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0032829	regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.1	GO:0042435	indole-containing compound biosynthetic process(GO:0042435)
0.0	0.0	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0	0.1	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0	0.1	GO:0036123	histone H3-K9 dimethylation(GO:0036123)
0.0	0.0	GO:0090086	negative regulation of protein deubiquitination(GO:0090086)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.1	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.2	GO:0007614	short-term memory(GO:0007614)
0.0	0.0	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.0	GO:0035283	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.0	GO:0048633	positive regulation of skeletal muscle tissue growth(GO:0048633)
0.0	0.1	GO:1903215	negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0	0.0	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.4	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.1	GO:0014043	negative regulation of neuron maturation(GO:0014043)
0.0	1.3	GO:0002230	positive regulation of defense response to virus by host(GO:0002230)
0.0	0.0	GO:0009219	pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0	0.1	GO:0001842	neural fold formation(GO:0001842)
0.0	0.1	GO:0046697	decidualization(GO:0046697)
0.0	0.0	GO:0000710	meiotic mismatch repair(GO:0000710)
0.0	0.1	GO:0035988	chondrocyte proliferation(GO:0035988)
0.0	0.0	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.0	GO:0002121	inter-male aggressive behavior(GO:0002121)
0.0	0.0	GO:0071677	positive regulation of mononuclear cell migration(GO:0071677)
0.0	0.0	GO:0044027	hypermethylation of CpG island(GO:0044027)
0.0	0.0	GO:2000041	regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0	0.0	GO:2000384	regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0	0.1	GO:0036158	outer dynein arm assembly(GO:0036158)
0.0	0.8	GO:2000177	regulation of neural precursor cell proliferation(GO:2000177)
0.0	0.0	GO:0019086	late viral transcription(GO:0019086)
0.0	0.1	GO:0010764	negative regulation of fibroblast migration(GO:0010764)
0.0	0.4	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.1	GO:0071435	potassium ion export(GO:0071435)
0.0	0.0	GO:0097428	protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0	0.0	GO:2001166	regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0	1.0	GO:0008213	protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.0	0.0	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0000379	tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0	0.0	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0	0.0	GO:0035279	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0	0.0	GO:0055009	atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0	0.1	GO:0021694	cerebellar Purkinje cell layer formation(GO:0021694)
0.0	0.2	GO:0045109	intermediate filament organization(GO:0045109)
0.0	0.3	GO:0006270	DNA replication initiation(GO:0006270)
0.0	0.0	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0	0.2	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.5	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.2	0.5	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.2	0.7	GO:0098536	deuterosome(GO:0098536)
0.1	0.9	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1	0.5	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1	1.3	GO:0072546	ER membrane protein complex(GO:0072546)
0.1	1.5	GO:0042581	specific granule(GO:0042581)
0.1	0.5	GO:0005828	kinetochore microtubule(GO:0005828)
0.1	0.6	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.1	1.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.1	0.4	GO:0016461	unconventional myosin complex(GO:0016461)
0.1	0.3	GO:0035363	histone locus body(GO:0035363)
0.1	0.2	GO:0033596	TSC1-TSC2 complex(GO:0033596)
0.1	0.2	GO:0044611	nuclear pore inner ring(GO:0044611)
0.1	0.6	GO:0035253	ciliary rootlet(GO:0035253)
0.1	0.2	GO:0033269	internode region of axon(GO:0033269)
0.0	0.6	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.1	GO:0000322	storage vacuole(GO:0000322)
0.0	0.5	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.2	GO:0034715	pICln-Sm protein complex(GO:0034715)
0.0	0.2	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.3	GO:0070652	HAUS complex(GO:0070652)
0.0	0.3	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.8	GO:0005732	small nucleolar ribonucleoprotein complex(GO:0005732)
0.0	0.7	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	0.8	GO:0000407	pre-autophagosomal structure(GO:0000407)
0.0	0.1	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.0	0.2	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.5	GO:0030014	CCR4-NOT complex(GO:0030014)
0.0	0.1	GO:1990246	uniplex complex(GO:1990246)
0.0	1.1	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	0.1	GO:0005914	spot adherens junction(GO:0005914)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.1	GO:0044352	pinosome(GO:0044352) macropinosome(GO:0044354)
0.0	0.7	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.0	0.3	GO:0042555	MCM complex(GO:0042555)
0.0	0.1	GO:0070110	ciliary neurotrophic factor receptor complex(GO:0070110)
0.0	1.3	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.0	0.3	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	1.2	GO:0014704	intercalated disc(GO:0014704)
0.0	0.2	GO:1990909	Wnt signalosome(GO:1990909)
0.0	0.6	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	0.5	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0	0.3	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.1	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.7	GO:0005776	autophagosome(GO:0005776)
0.0	0.2	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.0	0.1	GO:0036157	outer dynein arm(GO:0036157)
0.0	0.3	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.2	GO:0098799	outer mitochondrial membrane protein complex(GO:0098799)
0.0	0.1	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.2	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	0.1	GO:0000235	astral microtubule(GO:0000235)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	0.1	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.2	GO:0030057	desmosome(GO:0030057)
0.0	0.0	GO:0030868	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.1	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0	0.9	GO:0030018	Z disc(GO:0030018)
0.0	0.0	GO:0005833	hemoglobin complex(GO:0005833)
0.0	0.3	GO:0030863	cortical cytoskeleton(GO:0030863)
0.0	0.1	GO:0071014	post-mRNA release spliceosomal complex(GO:0071014)
0.0	0.2	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.7	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.3	1.5	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.2	0.7	GO:0015087	cobalt ion transmembrane transporter activity(GO:0015087)
0.2	0.5	GO:0019776	Atg8 ligase activity(GO:0019776)
0.2	0.5	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.1	2.0	GO:0008308	voltage-gated anion channel activity(GO:0008308)
0.1	1.4	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1	1.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.4	GO:0019808	polyamine binding(GO:0019808)
0.1	0.8	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.1	0.6	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.1	0.4	GO:1990932	5.8S rRNA binding(GO:1990932)
0.1	0.7	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.1	0.1	GO:0016426	tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.1	0.2	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1	0.8	GO:0070410	co-SMAD binding(GO:0070410)
0.1	0.8	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.1	0.6	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1	0.2	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1	0.9	GO:0070034	telomerase RNA binding(GO:0070034)
0.1	0.2	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.1	0.3	GO:0004565	beta-galactosidase activity(GO:0004565)
0.1	0.2	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
0.1	1.1	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1	0.6	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1	0.2	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	0.3	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.3	GO:0016681	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.1	GO:0005146	leukemia inhibitory factor receptor binding(GO:0005146)
0.0	0.2	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.4	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.3	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.1	GO:0015119	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.2	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.5	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.3	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.2	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.9	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.2	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0004942	anaphylatoxin receptor activity(GO:0004942)
0.0	0.6	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.1	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.5	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.2	GO:0102337	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.1	GO:0043262	adenosine-diphosphatase activity(GO:0043262)
0.0	0.4	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.0	0.2	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0	0.3	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.9	GO:0052770	coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.0	GO:0051373	FATZ binding(GO:0051373)
0.0	0.1	GO:0070051	fibrinogen binding(GO:0070051)
0.0	0.1	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0	2.2	GO:0009019	tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0	0.1	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0	0.1	GO:0051022	Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0	0.5	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.0	0.2	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0	0.1	GO:0005415	nucleoside:sodium symporter activity(GO:0005415)
0.0	0.2	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.3	GO:0001054	RNA polymerase I activity(GO:0001054)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.1	GO:0031720	haptoglobin binding(GO:0031720)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.3	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.4	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0071253	connexin binding(GO:0071253)
0.0	0.8	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0	0.1	GO:0035514	DNA demethylase activity(GO:0035514)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.1	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	0.2	GO:0015250	water channel activity(GO:0015250)
0.0	0.1	GO:0070137	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.5	GO:0050699	WW domain binding(GO:0050699)
0.0	0.2	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	0.6	GO:0042169	SH2 domain binding(GO:0042169)
0.0	0.2	GO:0031432	titin binding(GO:0031432)
0.0	0.4	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.2	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.1	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	1.2	GO:0015171	amino acid transmembrane transporter activity(GO:0015171)
0.0	0.1	GO:0032050	clathrin heavy chain binding(GO:0032050)
0.0	0.0	GO:0051021	GDP-dissociation inhibitor binding(GO:0051021)
0.0	0.1	GO:0016274	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.3	GO:0070008	serine-type exopeptidase activity(GO:0070008)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0052794	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0	0.2	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.0	GO:0004096	catalase activity(GO:0004096)
0.0	0.0	GO:0019976	interleukin-2 binding(GO:0019976)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	1.0	GO:0017048	Rho GTPase binding(GO:0017048)
0.0	0.2	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	0.0	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.6	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.1	GO:0005166	neurotrophin p75 receptor binding(GO:0005166)
0.0	0.0	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.0	0.2	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.4	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0	0.7	GO:0005518	collagen binding(GO:0005518)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.0	GO:0033592	RNA strand annealing activity(GO:0033592)
0.0	0.1	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.1	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758)
0.0	0.1	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.0	GO:0015232	heme transporter activity(GO:0015232)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	1.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.8	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.0	0.6	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.4	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.6	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.1	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.5	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	1.1	PID CDC42 PATHWAY	CDC42 signaling events
0.0	0.6	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	0.1	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
0.0	0.2	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	0.2	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.6	PID PLK1 PATHWAY	PLK1 signaling events
0.0	0.3	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.2	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	0.5	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	0.2	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	0.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	0.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	1.0	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.1	0.8	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.7	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.4	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	1.0	REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.0	0.5	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	0.6	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.2	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.8	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.4	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.4	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.3	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	0.0	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.0	0.6	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0	1.1	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.0	0.4	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	1.4	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	0.5	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.1	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.5	REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0	0.3	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	0.1	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions