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ENCODE: ATAC-seq of different tissues during embryonic development
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Glis1

Z-value: 0.48

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Transcription factors associated with Glis1

Gene Symbol Gene ID Gene Info
Glis1
ENSMUSG00000034762.3 Glis1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
Glis1chr4_107468527_107468678296040.1466900.473.3e-04Click!
Glis1chr4_107468345_107468521294350.1469530.383.9e-03Click!
Glis1chr4_107605910_10760624889210.194168-0.331.3e-02Click!
Glis1chr4_107606826_10760698780940.196124-0.331.3e-02Click!
Glis1chr4_107467954_107468105290310.1475790.293.1e-02Click!

Activity of the Glis1 motif across conditions

Conditions sorted by the z-value of the Glis1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr5_24730299_24730496 3.82 Wdr86
 WD repeat domain 86
 283
 0.87
chr7_29453052_29453769 3.54 Sipa1l3
 signal-induced proliferation-associated 1 like 3
 52042
 0.1
chr5_113635949_113636100 3.40 Cmklr1
 chemokine-like receptor 1
 7579
 0.16
chr3_87764321_87764732 2.46 Pear1
 platelet endothelial aggregation receptor 1
 2312
 0.22
chr7_45091386_45091868 2.41 Rcn3
 reticulocalbin 3, EF-hand calcium binding domain
 98
 0.62
chr6_135136423_135136864 2.26 Gm29803
 predicted gene, 29803
 2191
 0.2
chr4_147969190_147969341 2.02 Nppb
 natriuretic peptide type B
 16523
 0.09
chr7_3411029_3411836 1.79 Gm23450
 predicted gene, 23450
 3634
 0.11
chr5_52114565_52115511 1.76 Gm43177
 predicted gene 43177
 2274
 0.22
chr5_120005810_120006020 1.72 Gm38554
 predicted gene, 38554
 46672
 0.13
chr1_150991901_150992071 1.11 Hmcn1
 hemicentin 1
 1065
 0.52
chr15_93825328_93825719 1.08 Gm49445
 predicted gene, 49445
 485
 0.86
chr8_82943719_82943873 1.07 Gm18212
 predicted gene, 18212
 8716
 0.25
chr6_85254101_85254349 1.03 Sfxn5
 sideroflexin 5
 10708
 0.16
chr10_44589951_44590105 0.97 Gm5950
 predicted gene 5950
 100
 0.65
chr5_101765419_101765831 0.90 Cds1
 CDP-diacylglycerol synthase 1
 495
 0.77
chr6_42262194_42262445 0.89 Tmem139
 transmembrane protein 139
 349
 0.77
chr12_76572353_76572504 0.70 Plekhg3
 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
 878
 0.53
chr4_156248345_156248496 0.67 Samd11
 sterile alpha motif domain containing 11
 3660
 0.12
chr11_3289074_3290615 0.58 Patz1
 POZ (BTB) and AT hook containing zinc finger 1
 149
 0.93
chr4_141623114_141623302 0.56 Slc25a34
 solute carrier family 25, member 34
 613
 0.58
chr7_100930787_100931664 0.51 Arhgef17
 Rho guanine nucleotide exchange factor (GEF) 17
 882
 0.51
chr2_27122039_27122272 0.50 Adamtsl2
 ADAMTS-like 2
 17492
 0.11
chr15_99474144_99474817 0.48 Bcdin3d
 BCDIN3 domain containing
 228
 0.86
chr4_144893602_144894367 0.42 Dhrs3
 dehydrogenase/reductase (SDR family) member 3
 765
 0.69
chrX_151046578_151047462 0.39 Fgd1
 FYVE, RhoGEF and PH domain containing 1
 150
 0.95
chr3_87971441_87971954 0.39 Nes
 nestin
 568
 0.56
chr8_126903611_126903762 0.38 Gm31718
 predicted gene, 31718
 4529
 0.2
chrX_60891972_60892372 0.37 Sox3
 SRY (sex determining region Y)-box 3
 1258
 0.34
chr8_104602539_104603204 0.36 Cdh16
 cadherin 16
 10393
 0.09
chr2_59674040_59674316 0.34 Tanc1
 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
 27367
 0.23
chr15_63163951_63164159 0.34 Gm49013
 predicted gene, 49013
 17822
 0.21
chr4_133887658_133888457 0.33 Rps6ka1
 ribosomal protein S6 kinase polypeptide 1
 260
 0.86
chr11_117114876_117115708 0.32 Sec14l1
 SEC14-like lipid binding 1
 40
 0.96
chr17_56159615_56160011 0.31 Tnfaip8l1
 tumor necrosis factor, alpha-induced protein 8-like 1
 2664
 0.13
chr12_85523165_85523316 0.31 Gm32296
 predicted gene, 32296
 6358
 0.19
chr19_6951202_6952512 0.30 Bad
 BCL2-associated agonist of cell death
 1090
 0.24
chr2_58566508_58567083 0.29 Acvr1
 activin A receptor, type 1
 31
 0.91
chr12_98741435_98741655 0.29 Ptpn21
 protein tyrosine phosphatase, non-receptor type 21
 4140
 0.14
chr11_77462226_77462390 0.29 Coro6
 coronin 6
 103
 0.95
chr8_3493298_3493991 0.19 Zfp358
 zinc finger protein 358
 474
 0.67
chr1_133205071_133205255 0.18 Plekha6
 pleckstrin homology domain containing, family A member 6
 23842
 0.15
chr18_68871188_68871762 0.17 Gm50260
 predicted gene, 50260
 66117
 0.12
chr7_69490938_69491157 0.16 Gm38584
 predicted gene, 38584
 246
 0.92
chr8_84701108_84701942 0.14 Lyl1
 lymphoblastomic leukemia 1
 19
 0.95
chr4_133011887_133012661 0.14 Ahdc1
 AT hook, DNA binding motif, containing 1
 70
 0.97
chr17_37045564_37046927 0.12 Gabbr1
 gamma-aminobutyric acid (GABA) B receptor, 1
 46
 0.94
chr19_56722198_56722794 0.07 Adrb1
 adrenergic receptor, beta 1
 297
 0.88
chr13_12461787_12462200 0.05 Lgals8
 lectin, galactose binding, soluble 8
 255
 0.9
chr13_49308984_49309135 0.04 Fgd3
 FYVE, RhoGEF and PH domain containing 3
 181
 0.95
chr6_35651521_35651804 0.02 Gm42931
 predicted gene 42931
 35993
 0.21
chr15_102103920_102104453 0.02 Tns2
 tensin 2
 239
 0.87
chr1_172632394_172632933 0.01 Dusp23
 dual specificity phosphatase 23
 299
 0.86
chr10_67284607_67285827 0.00 Nrbf2
 nuclear receptor binding factor 2
 37
 0.97

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of Glis1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.6 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.1 0.3 GO:0003289 atrial septum primum morphogenesis(GO:0003289)
0.1 0.2 GO:0010446 response to alkaline pH(GO:0010446)
0.1 0.3 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 0.2 GO:0061366 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 0.4 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.1 0.3 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.1 0.2 GO:0015746 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0 0.1 GO:0097623 potassium ion export across plasma membrane(GO:0097623) regulation of potassium ion export(GO:1902302)
0.0 0.6 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.1 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.0 0.1 GO:0052041 induction of programmed cell death(GO:0012502) negative regulation by symbiont of host apoptotic process(GO:0033668) positive regulation of apoptotic process in other organism(GO:0044533) negative regulation by symbiont of host programmed cell death(GO:0052041) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501) positive regulation of apoptotic process by virus(GO:0060139) cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.1 GO:0070827 chromatin maintenance(GO:0070827)
0.0 0.1 GO:0032066 nucleolus to nucleoplasm transport(GO:0032066)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025) positive regulation of renin secretion into blood stream(GO:1900135)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.1 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.2 GO:0035810 positive regulation of urine volume(GO:0035810)
0.0 0.3 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0090085 regulation of protein deubiquitination(GO:0090085)
0.0 0.1 GO:0097062 dendritic spine maintenance(GO:0097062)
0.0 0.0 GO:0051891 positive regulation of cardioblast differentiation(GO:0051891)
0.0 1.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.0 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.1 GO:0018126 protein hydroxylation(GO:0018126)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.3 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.6 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0 0.1 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)
0.0 0.1 GO:0008091 spectrin(GO:0008091)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.1 0.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.3 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 0.2 GO:0015137 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.1 0.2 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.2 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0042731 PH domain binding(GO:0042731)
0.0 0.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.1 GO:0031493 nucleosomal histone binding(GO:0031493)
0.0 1.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.0 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.0 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 0.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.0 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.1 GO:1990381 ubiquitin-specific protease binding(GO:1990381)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.2 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.6 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.3 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK