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ENCODE: ATAC-seq of different tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Gzf1

Z-value: 1.27

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Transcription factors associated with Gzf1

Gene Symbol	Gene ID	Gene Info
Gzf1 Ensembl NCBI MGI UniProt	ENSMUSG00000027439.9	Gzf1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Gzf1	chr2_148685781_148685971	1264	0.390753	-0.65	8.4e-08	Click!
Gzf1	chr2_148685983_148686204	1481	0.339685	-0.62	3.5e-07	Click!
Gzf1	chr2_148677887_148678489	2835	0.209566	0.62	5.3e-07	Click!
Gzf1	chr2_148677656_148677863	3264	0.194164	0.52	5.4e-05	Click!
Gzf1	chr2_148679740_148679915	1196	0.412048	0.45	6.5e-04	Click!

Activity of the Gzf1 motif across conditions

Conditions sorted by the z-value of the Gzf1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr17_13590938_13591623	29.30	2700054A10Rik	RIKEN cDNA 2700054A10 gene	22416	0.14
chr12_70345856_70346098	12.27	Trim9	tripartite motif-containing 9	1112	0.41
chr5_39733465_39733625	9.09	Hs3st1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	21930	0.23
chr16_72027511_72027683	8.73	Gm49667	predicted gene, 49667	148553	0.04
chr12_113186726_113187124	8.62	Tmem121	transmembrane protein 121	995	0.4
chr17_13654565_13655321	8.30	2700054A10Rik	RIKEN cDNA 2700054A10 gene	13948	0.15
chr17_13589870_13590228	7.41	2700054A10Rik	RIKEN cDNA 2700054A10 gene	21185	0.15
chr18_76469379_76469553	7.39	Gm50360	predicted gene, 50360	147642	0.04
chr2_62807204_62807376	7.25	Gm13569	predicted gene 13569	1897	0.37
chr17_13586214_13586541	6.98	2700054A10Rik	RIKEN cDNA 2700054A10 gene	17513	0.15
chr10_59958140_59958359	6.61	Ddit4	DNA-damage-inducible transcript 4	6415	0.18
chr17_13590288_13590503	6.55	2700054A10Rik	RIKEN cDNA 2700054A10 gene	21531	0.15
chr2_170772344_170772652	6.39	Dok5	docking protein 5	40691	0.19
chr11_68947505_68947921	6.38	Arhgef15	Rho guanine nucleotide exchange factor (GEF) 15	48	0.94
chr15_41162973_41163124	5.80	4930555K19Rik	RIKEN cDNA 4930555K19 gene	10439	0.28
chr13_71964060_71964241	5.60	Irx1	Iroquois homeobox 1	427	0.88
chr14_80216319_80216498	5.49	Gm17923	predicted gene, 17923	1478	0.55
chr2_102450292_102450505	5.39	Fjx1	four jointed box 1	2101	0.38
chr6_112287813_112287964	5.36	5031434C07Rik	RIKEN cDNA 5031434C07 gene	948	0.51
chr17_31057840_31058322	4.93	Abcg1	ATP binding cassette subfamily G member 1	307	0.82
chr12_95694111_95694481	4.80	Flrt2	fibronectin leucine rich transmembrane protein 2	1061	0.51
chr6_6884897_6885228	4.71	Dlx5	distal-less homeobox 5	2977	0.17
chr7_144133020_144133171	4.56	Gm44999	predicted gene 44999	22010	0.2
chr7_130367520_130367715	4.55	Gm5903	predicted gene 5903	13255	0.22
chr5_99037530_99037747	4.41	Prkg2	protein kinase, cGMP-dependent, type II	287	0.93
chr11_77078150_77078604	4.40	Nsrp1	nuclear speckle regulatory protein 1	58	0.69
chr4_98223390_98223614	4.33	Gm12692	predicted gene 12692	11788	0.21
chr13_36613172_36613399	4.17	Gm46409	predicted gene, 46409	313	0.87
chr2_100865612_100865778	4.15	Gm13810	predicted gene 13810	237652	0.02
chr1_180725622_180726589	4.10	Acbd3	acyl-Coenzyme A binding domain containing 3	62	0.95
chr12_85598845_85599442	4.09	Gm47863	predicted gene, 47863	48	0.58
chr4_124861815_124862142	4.02	Maneal	mannosidase, endo-alpha-like	193	0.89
chr7_6343440_6343815	4.00	Gm3854	predicted gene 3854	132	0.75
chr7_4842196_4842588	3.96	Shisa7	shisa family member 7	2304	0.13
chr1_173366946_173367141	3.76	Cadm3	cell adhesion molecule 3	590	0.7
chr11_68341740_68341891	3.67	Ntn1	netrin 1	45011	0.14
chr14_58071780_58071984	3.65	Fgf9	fibroblast growth factor 9	804	0.62
chr1_47278444_47278595	3.60	Gm4852	predicted pseudogene 4852	87853	0.09
chr12_65259311_65259487	3.52	Gm47973	predicted gene, 47973	7689	0.19
chr2_57614579_57615021	3.44	Gm13532	predicted gene 13532	14428	0.2
chr6_109874355_109874582	3.43	Gm44162	predicted gene, 44162	158921	0.04
chr4_109763223_109763401	3.36	Gm12808	predicted gene 12808	8495	0.24
chr7_63444022_63445137	3.34	4930554H23Rik	RIKEN cDNA 4930554H23 gene	50	0.67
chr18_56015322_56015473	3.32	Gm6944	predicted gene 6944	43111	0.15
chr11_100333236_100333409	3.19	Gast	gastrin	1085	0.28
chr19_48204971_48205291	3.18	Sorcs3	sortilin-related VPS10 domain containing receptor 3	894	0.67
chr18_44754207_44754358	3.14	Mcc	mutated in colorectal cancers	29624	0.17
chr3_50381590_50381769	3.11	Slc7a11	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	10880	0.23
chrX_7610162_7610425	3.10	Cacna1f	calcium channel, voltage-dependent, alpha 1F subunit	3149	0.1
chr12_50809018_50809169	3.10	Gm48779	predicted gene, 48779	55996	0.15
chr15_85678936_85679636	3.04	Lncppara	long noncoding RNA near Ppara	24487	0.12
chr1_66387135_66387333	3.03	Map2	microtubule-associated protein 2	223	0.94
chr5_63649551_63649743	3.02	Nwd2	NACHT and WD repeat domain containing 2	314	0.72
chr7_73740150_73741122	3.01	A830073O21Rik	RIKEN cDNA A830073O21 gene	281	0.52
chr3_56962365_56962516	2.94	Gm22269	predicted gene, 22269	91710	0.09
chr11_20878789_20878940	2.89	Gm22807	predicted gene, 22807	30983	0.13
chr11_94281227_94281543	2.88	Gm21885	predicted gene, 21885	488	0.76
chr4_130055268_130055419	2.87	Col16a1	collagen, type XVI, alpha 1	288	0.87
chr17_13587362_13587709	2.82	2700054A10Rik	RIKEN cDNA 2700054A10 gene	18671	0.15
chr5_39417055_39417230	2.72	Gm5291	predicted gene 5291	14897	0.17
chr4_31049383_31049534	2.68	Gm25705	predicted gene, 25705	125554	0.06
chr5_139129572_139129764	2.68	Prkar1b	protein kinase, cAMP dependent regulatory, type I beta	91	0.96
chr16_20619916_20620680	2.57	Camk2n2	calcium/calmodulin-dependent protein kinase II inhibitor 2	989	0.25
chr16_28444957_28445377	2.53	Fgf12	fibroblast growth factor 12	908	0.74
chr17_67764573_67764743	2.45	Lama1	laminin, alpha 1	47748	0.16
chr8_23411129_23412450	2.45	Sfrp1	secreted frizzled-related protein 1	287	0.94
chr11_57694554_57694848	2.44	4933426K07Rik	RIKEN cDNA 4933426K07 gene	36875	0.11
chr1_118954540_118954691	2.39	Mir6346	microRNA 6346	395	0.88
chr12_32926365_32926853	2.39	Gm19056	predicted gene, 19056	3338	0.15
chr7_83477873_83478111	2.38	Gm44991	predicted gene 44991	6284	0.21
chr6_54008819_54008970	2.36	4921529L05Rik	RIKEN cDNA 4921529L05 gene	818	0.64
chr15_95702329_95702480	2.36	Gm8843	predicted gene 8843	12789	0.16
chr11_35914912_35915063	2.35	Wwc1	WW, C2 and coiled-coil domain containing 1	39275	0.16
chr6_85451222_85452476	2.33	Pradc1	protease-associated domain containing 1	96	0.6
chr7_84483886_84484050	2.33	Gm45175	predicted gene 45175	39417	0.11
chr2_146810745_146810896	2.32	Gm14114	predicted gene 14114	28912	0.18
chr11_47343450_47343810	2.31	Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	35892	0.23
chr4_154960842_154960993	2.30	Hes5	hes family bHLH transcription factor 5	6	0.93
chr4_63528950_63529291	2.26	Atp6v1g1	ATPase, H+ transporting, lysosomal V1 subunit G1	15652	0.12
chr3_137762653_137762804	2.24	Mir6380	microRNA 6380	20887	0.13
chr2_25290168_25290373	2.14	Lrrc26	leucine rich repeat containing 26	355	0.57
chr9_14751478_14752576	2.12	Fut4	fucosyltransferase 4	366	0.74
chr5_111218146_111218303	2.11	Ttc28	tetratricopeptide repeat domain 28	7234	0.2
chr2_159002609_159002760	2.08	Gm44319	predicted gene, 44319	67179	0.12
chr2_136108035_136108369	2.06	Gm14218	predicted gene 14218	28804	0.19
chr9_73681333_73681484	2.05	Gm27148	predicted gene 27148	4716	0.31
chr14_124192867_124193151	2.03	Fgf14	fibroblast growth factor 14	107	0.98
chr13_81596951_81597255	1.96	Adgrv1	adhesion G protein-coupled receptor V1	12247	0.22
chr10_79681206_79682337	1.95	Cdc34	cell division cycle 34	424	0.63
chr10_98007193_98007368	1.92	Gm10754	predicted gene 10754	40190	0.21
chr11_35927335_35927561	1.90	Wwc1	WW, C2 and coiled-coil domain containing 1	51736	0.13
chr5_39772042_39772399	1.90	Hs3st1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	16745	0.22
chr12_72069940_72071249	1.89	Gpr135	G protein-coupled receptor 135	531	0.72
chr16_85086037_85086188	1.87	Gm49227	predicted gene, 49227	6001	0.22
chr3_45377659_45378144	1.86	2610316D01Rik	RIKEN cDNA 2610316D01 gene	304	0.65
chr18_12827295_12827569	1.85	Osbpl1a	oxysterol binding protein-like 1A	7525	0.19
chr3_116512768_116512919	1.85	Dbt	dihydrolipoamide branched chain transacylase E2	227	0.87
chr7_16869301_16869754	1.84	Prkd2	protein kinase D2	275	0.8
chr8_16965821_16965972	1.83	3110080E11Rik	RIKEN cDNA 3110080E11 gene	49714	0.18
chr7_4844524_4844964	1.82	Shisa7	shisa family member 7	48	0.94
chr3_93443881_93444908	1.82	Tchh	trichohyalin	2064	0.16
chr4_99295280_99295454	1.82	Gm12689	predicted gene 12689	533	0.78
chr8_4350654_4350950	1.76	Ccl25	chemokine (C-C motif) ligand 25	1214	0.32
chr2_152142100_152142333	1.75	Tcf15	transcription factor 15	1345	0.37
chr8_70487251_70487452	1.73	Tmem59l	transmembrane protein 59-like	7	0.92
chr16_25407448_25407917	1.72	Gm18896	predicted gene, 18896	35591	0.22
chr4_125583445_125583596	1.69	Mir692-2	microRNA 692-2	78771	0.09
chr10_86492372_86492584	1.69	Syn3	synapsin III	581	0.65
chr4_6717891_6718227	1.67	Tox	thymocyte selection-associated high mobility group box	28708	0.19
chr1_132283002_132283375	1.66	Gm7241	predicted pseudogene 7241	1265	0.3
chr6_58907455_58907637	1.65	Herc3	hect domain and RLD 3	284	0.65
chr6_29396003_29396644	1.63	Ccdc136	coiled-coil domain containing 136	14	0.79
chr13_31792557_31792841	1.60	Gm11379	predicted gene 11379	4840	0.19
chr14_18893044_18894412	1.58	Ube2e2	ubiquitin-conjugating enzyme E2E 2	10	0.98
chr18_60926924_60927473	1.56	Camk2a	calcium/calmodulin-dependent protein kinase II alpha	249	0.89
chr4_118127727_118128030	1.51	St3gal3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	7004	0.17
chr1_19951381_19951572	1.47	Gm37315	predicted gene, 37315	114072	0.07
chr4_85831629_85831812	1.47	Gm25811	predicted gene, 25811	211774	0.02
chr16_69469408_69469596	1.47	4930428D20Rik	RIKEN cDNA 4930428D20 gene	330879	0.01
chr3_146345584_146345902	1.47	Gm43334	predicted gene 43334	21323	0.14
chr15_9061253_9061404	1.47	Nadk2	NAD kinase 2, mitochondrial	9932	0.22
chr12_46075749_46076236	1.46	Gm24948	predicted gene, 24948	91649	0.09
chr6_14900485_14900732	1.44	Foxp2	forkhead box P2	741	0.8
chr16_52303296_52303447	1.44	Alcam	activated leukocyte cell adhesion molecule	6447	0.33
chr15_74518307_74518458	1.44	Adgrb1	adhesion G protein-coupled receptor B1	1551	0.4
chr1_152399789_152399970	1.43	Colgalt2	collagen beta(1-O)galactosyltransferase 2	49	0.98
chr17_80372913_80373671	1.39	Gm10190	predicted gene 10190	249	0.62
chr9_26454070_26454221	1.39	Gm48373	predicted gene, 48373	67843	0.11
chr2_131040943_131041967	1.38	Gfra4	glial cell line derived neurotrophic factor family receptor alpha 4	2	0.94
chr6_32328132_32328283	1.38	Plxna4os3	plexin A4, opposite strand 3	24294	0.24
chr8_105268194_105269524	1.37	Hsf4	heat shock transcription factor 4	942	0.26
chr16_25465879_25466059	1.36	Gm18896	predicted gene, 18896	22696	0.27
chr5_137583806_137584189	1.35	Tfr2	transferrin receptor 2	712	0.39
chr7_67071811_67071967	1.34	Gm17909	predicted gene, 17909	10954	0.19
chr12_9166625_9166808	1.34	Ttc32	tetratricopeptide repeat domain 32	136688	0.04
chr3_55756315_55756785	1.30	Mab21l1	mab-21-like 1	25960	0.18
chr4_124036517_124036668	1.30	Gm12902	predicted gene 12902	110358	0.05
chr7_129793883_129794034	1.29	Gm44778	predicted gene 44778	39088	0.2
chr11_120223944_120224378	1.29	Gm11770	predicted gene 11770	7168	0.1
chrX_140957056_140957443	1.26	Atg4a	autophagy related 4A, cysteine peptidase	299	0.68
chr12_117159354_117159563	1.25	Gm10421	predicted gene 10421	7807	0.3
chr13_35968213_35969019	1.24	Ppp1r3g	protein phosphatase 1, regulatory subunit 3G	670	0.57
chr15_56692188_56692969	1.23	Has2os	hyaluronan synthase 2, opposite strand	974	0.55
chr5_12498341_12498532	1.23	Sema3d	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	13481	0.21
chr8_98365520_98365671	1.19	Gm7192	predicted gene 7192	140932	0.05
chr1_170176895_170177131	1.17	Gm37502	predicted gene, 37502	759	0.47
chr11_121702189_121702884	1.17	Metrnl	meteorin, glial cell differentiation regulator-like	125	0.97
chr16_70535346_70535522	1.17	Gbe1	glucan (1,4-alpha-), branching enzyme 1	25560	0.24
chr3_103733715_103734513	1.16	Olfml3	olfactomedin-like 3	115	0.93
chr5_9100833_9101781	1.15	Tmem243	transmembrane protein 243, mitochondrial	560	0.74
chr17_36189653_36190417	1.15	H2-T3	histocompatibility 2, T region locus 3	87	0.86
chr3_31308342_31308493	1.13	Slc7a14	solute carrier family 7 (cationic amino acid transporter, y+ system), member 14	1961	0.31
chr16_56920328_56920584	1.12	Lnp1	leukemia NUP98 fusion partner 1	7605	0.16
chr10_85386973_85388092	1.12	Btbd11	BTB (POZ) domain containing 11	705	0.72
chr19_8710179_8710404	1.11	Slc3a2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	2694	0.07
chr2_44565118_44565293	1.11	Gtdc1	glycosyltransferase-like domain containing 1	6142	0.33
chr3_89225307_89226347	1.11	Thbs3	thrombospondin 3	423	0.5
chr10_4006205_4006393	1.11	Gm16074	predicted gene 16074	13928	0.17
chr4_45297019_45297341	1.10	Trmt10b	tRNA methyltransferase 10B	25	0.97
chr10_3920376_3921003	1.09	Gm23023	predicted gene, 23023	14188	0.15
chr17_76658153_76658304	1.09	Gm18366	predicted gene, 18366	163262	0.04
chr7_46639145_46639386	1.08	Sergef	secretion regulating guanine nucleotide exchange factor	315	0.84
chr14_118768381_118768663	1.06	Gm22379	predicted gene, 22379	6630	0.17
chr2_131304736_131304905	1.05	Gm14233	predicted gene 14233	6275	0.12
chr4_12287368_12287519	1.05	Gm11846	predicted gene 11846	16044	0.22
chr18_73059570_73059810	1.04	Gm31908	predicted gene, 31908	138600	0.05
chr6_71772911_71773062	1.04	Gm44769	predicted gene 44769	17682	0.12
chr19_4508691_4508955	1.03	Pcx	pyruvate carboxylase	1649	0.27
chr16_33739926_33740090	1.03	Heg1	heart development protein with EGF-like domains 1	8407	0.21
chr11_59227641_59228869	1.02	Arf1	ADP-ribosylation factor 1	15	0.95
chr8_14991358_14991509	1.00	Arhgef10	Rho guanine nucleotide exchange factor (GEF) 10	1074	0.39
chr5_70995664_70996254	0.99	Gabra2	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	17725	0.29
chr6_38730546_38730697	0.99	Hipk2	homeodomain interacting protein kinase 2	12639	0.22
chr6_97883597_97883757	0.96	Gm15531	predicted gene 15531	6862	0.26
chr16_18588056_18588353	0.96	Tbx1	T-box 1	604	0.61
chr5_24595821_24595972	0.96	Smarcd3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	953	0.34
chr1_67065202_67065417	0.95	Lancl1	LanC (bacterial lantibiotic synthetase component C)-like 1	26437	0.18
chr1_163314015_163314239	0.95	Prrx1	paired related homeobox 1	417	0.83
chrX_48170424_48170619	0.95	Sash3	SAM and SH3 domain containing 3	24085	0.15
chr4_128991868_128992156	0.94	Ak2	adenylate kinase 2	54	0.97
chrX_103289004_103289290	0.93	Gm19200	predicted gene, 19200	177	0.86
chr7_124704634_124704798	0.93	3100003L05Rik	RIKEN cDNA 3100003L05 gene	4219	0.35
chr5_142509557_142509714	0.91	Radil	Ras association and DIL domains	24	0.97
chr18_12917222_12917373	0.91	Gm5687	predicted gene 5687	18870	0.16
chr5_105655269_105655420	0.91	Lrrc8d	leucine rich repeat containing 8D	44625	0.14
chr10_67536867_67537245	0.89	Egr2	early growth response 2	813	0.53
chr11_101785577_101785749	0.87	Etv4	ets variant 4	292	0.88
chr15_61448570_61448721	0.87	Gm24696	predicted gene, 24696	90641	0.09
chr1_47604096_47604257	0.87	Gm37196	predicted gene, 37196	1820	0.44
chr4_70058924_70059247	0.87	Gm11225	predicted gene 11225	11928	0.28
chrX_94990647_94990838	0.86	Gm371	predicted pseudogene 371	7941	0.22
chr7_98692838_98693482	0.86	Gm15506	predicted gene 15506	9274	0.13
chr4_129959595_129960137	0.83	1700003M07Rik	RIKEN cDNA 1700003M07 gene	508	0.71
chr5_139907692_139908613	0.83	Elfn1	leucine rich repeat and fibronectin type III, extracellular 1	209	0.93
chr1_74092335_74092587	0.81	Tns1	tensin 1	1110	0.49
chr3_7424444_7424644	0.79	Pkia	protein kinase inhibitor, alpha	4514	0.21
chr2_4442210_4442396	0.79	Gm13175	predicted gene 13175	24367	0.17
chr8_16114909_16115569	0.78	Mir3106	microRNA 3106	53599	0.16
chr16_34572272_34572475	0.78	Kalrn	kalirin, RhoGEF kinase	1159	0.62
chr14_22760839_22761006	0.77	Gm7473	predicted gene 7473	14322	0.29

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Gzf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.0	6.0	GO:2000297	negative regulation of synapse maturation(GO:2000297)
1.3	4.0	GO:0034436	glycoprotein transport(GO:0034436)
1.1	2.1	GO:2000974	negative regulation of pro-B cell differentiation(GO:2000974)
1.0	5.1	GO:0031339	negative regulation of vesicle fusion(GO:0031339)
0.8	2.4	GO:0061343	cell adhesion involved in heart morphogenesis(GO:0061343)
0.8	2.3	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.7	2.0	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.5	1.6	GO:0089700	protein kinase D signaling(GO:0089700)
0.4	2.5	GO:0036289	peptidyl-serine autophosphorylation(GO:0036289)
0.3	2.6	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3	1.5	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.3	0.9	GO:0009136	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.3	1.1	GO:2000507	positive regulation of energy homeostasis(GO:2000507)
0.3	0.8	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.3	0.8	GO:0097212	lysosomal membrane organization(GO:0097212)
0.3	0.8	GO:0060166	olfactory pit development(GO:0060166)
0.3	1.1	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.3	2.6	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.2	0.9	GO:0051697	protein delipidation(GO:0051697)
0.2	2.1	GO:1900452	regulation of long term synaptic depression(GO:1900452)
0.2	0.2	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.2	1.4	GO:0090261	positive regulation of inclusion body assembly(GO:0090261)
0.2	1.1	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.2	0.6	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.2	0.8	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.2	3.0	GO:0033622	integrin activation(GO:0033622)
0.2	0.5	GO:0061366	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.2	0.5	GO:0021593	rhombomere morphogenesis(GO:0021593)
0.1	2.3	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1	1.0	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1	1.5	GO:0036065	fucosylation(GO:0036065)
0.1	0.8	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1	0.3	GO:0003278	apoptotic process involved in heart morphogenesis(GO:0003278)
0.1	0.5	GO:0000320	re-entry into mitotic cell cycle(GO:0000320)
0.1	2.2	GO:0010842	retina layer formation(GO:0010842)
0.1	0.4	GO:0030382	sperm mitochondrion organization(GO:0030382)
0.1	0.5	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.1	1.5	GO:0031065	positive regulation of histone deacetylation(GO:0031065)
0.1	0.3	GO:0021986	epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1	0.4	GO:0003219	cardiac right ventricle formation(GO:0003219)
0.1	0.6	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.1	1.2	GO:0045820	negative regulation of glycolytic process(GO:0045820) negative regulation of cofactor metabolic process(GO:0051195) negative regulation of coenzyme metabolic process(GO:0051198)
0.1	1.6	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1	0.9	GO:1904869	protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.1	0.3	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.1	1.2	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1	0.8	GO:0048664	neuron fate determination(GO:0048664)
0.1	0.3	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.1	0.3	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.1	0.3	GO:1900623	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1	0.2	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.1	2.8	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1	0.4	GO:0048496	maintenance of organ identity(GO:0048496)
0.1	0.3	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1	0.1	GO:1904251	regulation of bile acid metabolic process(GO:1904251)
0.1	0.4	GO:0046487	glyoxylate metabolic process(GO:0046487)
0.1	0.2	GO:0006068	ethanol catabolic process(GO:0006068)
0.1	0.2	GO:0090271	positive regulation of fibroblast growth factor production(GO:0090271)
0.1	0.4	GO:0006776	vitamin A metabolic process(GO:0006776)
0.1	3.0	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1	0.5	GO:0033572	transferrin transport(GO:0033572)
0.1	0.2	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.1	1.7	GO:2001258	negative regulation of cation channel activity(GO:2001258)
0.1	0.4	GO:0007253	cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1	0.2	GO:0046391	5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1	0.5	GO:0060346	bone trabecula formation(GO:0060346)
0.1	0.1	GO:0002159	desmosome assembly(GO:0002159)
0.1	0.2	GO:0010994	regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1	0.2	GO:0018364	peptidyl-glutamine methylation(GO:0018364)
0.1	0.2	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.1	0.6	GO:0071625	vocalization behavior(GO:0071625)
0.0	0.4	GO:0071493	cellular response to UV-B(GO:0071493)
0.0	0.2	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.1	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0	0.3	GO:1900107	regulation of nodal signaling pathway(GO:1900107)
0.0	0.1	GO:2000828	regulation of parathyroid hormone secretion(GO:2000828)
0.0	0.4	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0	0.1	GO:0010912	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.4	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	2.8	GO:0001578	microtubule bundle formation(GO:0001578)
0.0	0.1	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0	1.0	GO:0032094	response to food(GO:0032094)
0.0	0.1	GO:0072396	response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.3	GO:0071073	positive regulation of phospholipid biosynthetic process(GO:0071073)
0.0	0.1	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.2	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0014735	regulation of muscle atrophy(GO:0014735)
0.0	0.1	GO:0033505	floor plate morphogenesis(GO:0033505)
0.0	0.1	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
0.0	0.2	GO:2000465	regulation of glycogen (starch) synthase activity(GO:2000465)
0.0	0.4	GO:0016486	peptide hormone processing(GO:0016486)
0.0	0.1	GO:0010693	negative regulation of alkaline phosphatase activity(GO:0010693)
0.0	3.2	GO:0006694	steroid biosynthetic process(GO:0006694)
0.0	0.1	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.2	GO:0045217	cell-cell junction maintenance(GO:0045217)
0.0	0.1	GO:0018231	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.3	GO:0035357	peroxisome proliferator activated receptor signaling pathway(GO:0035357)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.4	GO:0006221	pyrimidine nucleotide biosynthetic process(GO:0006221)
0.0	0.2	GO:0070269	pyroptosis(GO:0070269)
0.0	0.1	GO:1903147	negative regulation of macromitophagy(GO:1901525) negative regulation of mitophagy(GO:1903147)
0.0	0.1	GO:0019856	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0	0.1	GO:0042494	detection of bacterial lipoprotein(GO:0042494)
0.0	0.1	GO:0051798	positive regulation of hair follicle development(GO:0051798)
0.0	0.0	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.0	GO:1903587	regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.0	0.0	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0	0.1	GO:0039530	MDA-5 signaling pathway(GO:0039530)
0.0	0.0	GO:0034454	microtubule anchoring at centrosome(GO:0034454)
0.0	0.3	GO:0022011	myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0	0.0	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
0.0	0.1	GO:0097062	dendritic spine maintenance(GO:0097062)
0.0	0.1	GO:0042359	vitamin D metabolic process(GO:0042359)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:2000354	regulation of ovarian follicle development(GO:2000354)
0.0	0.3	GO:0045109	intermediate filament organization(GO:0045109)
0.0	0.0	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.7	GO:0010633	negative regulation of epithelial cell migration(GO:0010633)
0.0	0.2	GO:0008340	determination of adult lifespan(GO:0008340)
0.0	0.0	GO:1901838	positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0	0.3	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	0.1	GO:0003351	epithelial cilium movement(GO:0003351)
0.0	0.0	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.0	GO:0002913	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.0	GO:0009912	auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0	0.0	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.1	GO:0031507	heterochromatin assembly(GO:0031507)
0.0	0.8	GO:0030279	negative regulation of ossification(GO:0030279)
0.0	0.1	GO:0006851	mitochondrial calcium ion transport(GO:0006851)
0.0	0.1	GO:0060297	regulation of sarcomere organization(GO:0060297)
0.0	0.0	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.0	0.1	GO:1904729	regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0007207	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.0	GO:0021707	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.6	GO:0007566	embryo implantation(GO:0007566)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.6	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.0	0.0	GO:0035928	rRNA import into mitochondrion(GO:0035928)
0.0	0.0	GO:0043396	corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.0	GO:0030214	hyaluronan catabolic process(GO:0030214) regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0	0.0	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.4	GO:0043029	T cell homeostasis(GO:0043029)
0.0	0.6	GO:0006334	nucleosome assembly(GO:0006334)
0.0	0.1	GO:0006622	protein targeting to lysosome(GO:0006622)
0.0	0.2	GO:0048490	anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0	0.0	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0034287	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) regulation of epinephrine secretion(GO:0014060) negative regulation of epinephrine secretion(GO:0032811) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.1	GO:0097034	mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0	0.1	GO:0032310	prostaglandin secretion(GO:0032310)
0.0	0.0	GO:0034197	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.3	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.0	GO:0031860	telomeric 3' overhang formation(GO:0031860)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.6	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.3	0.5	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.2	0.6	GO:0002142	stereocilia ankle link complex(GO:0002142)
0.1	0.4	GO:0005608	laminin-3 complex(GO:0005608)
0.1	0.9	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.1	0.3	GO:0005944	phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.1	0.7	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1	0.5	GO:0016012	sarcoglycan complex(GO:0016012)
0.1	0.4	GO:1990246	uniplex complex(GO:1990246)
0.1	2.2	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.1	1.5	GO:0032839	dendrite cytoplasm(GO:0032839)
0.1	0.6	GO:0005883	neurofilament(GO:0005883)
0.1	0.1	GO:1990812	growth cone filopodium(GO:1990812)
0.1	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.2	GO:0032444	activin responsive factor complex(GO:0032444)
0.1	2.7	GO:0043198	dendritic shaft(GO:0043198)
0.0	1.0	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	6.1	GO:0008021	synaptic vesicle(GO:0008021)
0.0	0.9	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.4	GO:1990023	mitotic spindle midzone(GO:1990023)
0.0	0.2	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.0	0.2	GO:0032584	growth cone membrane(GO:0032584)
0.0	0.7	GO:0042101	T cell receptor complex(GO:0042101)
0.0	1.5	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	0.2	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	0.4	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.2	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	0.1	GO:0002079	inner acrosomal membrane(GO:0002079)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	2.9	GO:0016607	nuclear speck(GO:0016607)
0.0	9.3	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	1.6	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	2.5	GO:0055037	recycling endosome(GO:0055037)
0.0	0.4	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	5.0	GO:0000139	Golgi membrane(GO:0000139)
0.0	0.1	GO:0048476	Holliday junction resolvase complex(GO:0048476)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.5	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.2	GO:0030123	AP-3 adaptor complex(GO:0030123)
0.0	1.2	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.0	0.3	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	0.1	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
0.0	0.8	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.0	GO:0036449	microtubule minus-end(GO:0036449)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	0.1	GO:1990131	EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0	2.6	GO:0031965	nuclear membrane(GO:0031965)
0.0	0.1	GO:0016600	flotillin complex(GO:0016600)
0.0	0.9	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.0	0.1	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.0	0.7	GO:0031012	extracellular matrix(GO:0031012)
0.0	0.2	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	0.3	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0030915	Smc5-Smc6 complex(GO:0030915)
0.0	0.2	GO:0071004	U2-type prespliceosome(GO:0071004)
0.0	0.0	GO:0097513	myosin II filament(GO:0097513)
0.0	0.1	GO:0016272	prefoldin complex(GO:0016272)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.3	4.0	GO:0034040	lipid-transporting ATPase activity(GO:0034040)
1.0	2.9	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.5	1.5	GO:0042296	ISG15 transferase activity(GO:0042296)
0.5	2.5	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.4	2.6	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.3	4.1	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.3	8.5	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.3	0.9	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.3	0.8	GO:2001069	glycogen binding(GO:2001069)
0.3	3.9	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.2	0.6	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.2	0.6	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
0.1	0.7	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1	2.3	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.1	1.0	GO:0016004	phospholipase activator activity(GO:0016004)
0.1	7.0	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1	0.3	GO:0034618	arginine binding(GO:0034618)
0.1	0.9	GO:0004017	adenylate kinase activity(GO:0004017)
0.1	1.5	GO:0004697	protein kinase C activity(GO:0004697)
0.1	0.3	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.1	1.9	GO:0052859	dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.1	2.1	GO:0071837	HMG box domain binding(GO:0071837)
0.1	0.4	GO:0003680	AT DNA binding(GO:0003680)
0.1	0.3	GO:0018594	mono-butyltin dioxygenase activity(GO:0018586) tri-n-butyltin dioxygenase activity(GO:0018588) di-n-butyltin dioxygenase activity(GO:0018589) methylsilanetriol hydroxylase activity(GO:0018590) methyl tertiary butyl ether 3-monooxygenase activity(GO:0018591) 4-nitrocatechol 4-monooxygenase activity(GO:0018592) 4-chlorophenoxyacetate monooxygenase activity(GO:0018593) tert-butanol 2-monooxygenase activity(GO:0018594) alpha-pinene monooxygenase activity(GO:0018595) dimethylsilanediol hydroxylase activity(GO:0018596) ammonia monooxygenase activity(GO:0018597) hydroxymethylsilanetriol oxidase activity(GO:0018598) 2-hydroxyisobutyrate 3-monooxygenase activity(GO:0018599) alpha-pinene dehydrogenase activity(GO:0018600) bisphenol A hydroxylase B activity(GO:0034559) 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity(GO:0034562) 9-fluorenone-3,4-dioxygenase activity(GO:0034786) anthracene 9,10-dioxygenase activity(GO:0034816) 2-(methylthio)benzothiazole monooxygenase activity(GO:0034857) 2-hydroxybenzothiazole monooxygenase activity(GO:0034858) benzothiazole monooxygenase activity(GO:0034859) 2,6-dihydroxybenzothiazole monooxygenase activity(GO:0034862) pinacolone 5-monooxygenase activity(GO:0034870) thioacetamide S-oxygenase activity(GO:0034873) thioacetamide S-oxide S-oxygenase activity(GO:0034874) endosulfan monooxygenase I activity(GO:0034888) N-nitrodimethylamine hydroxylase activity(GO:0034893) 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity(GO:0034897) endosulfan ether monooxygenase activity(GO:0034903) pyrene 4,5-monooxygenase activity(GO:0034925) pyrene 1,2-monooxygenase activity(GO:0034927) 1-hydroxypyrene 6,7-monooxygenase activity(GO:0034928) 1-hydroxypyrene 7,8-monooxygenase activity(GO:0034929) phenylboronic acid monooxygenase activity(GO:0034950) spheroidene monooxygenase activity(GO:0043823)
0.1	1.2	GO:0015026	coreceptor activity(GO:0015026)
0.1	1.4	GO:0032794	GTPase activating protein binding(GO:0032794)
0.1	0.4	GO:0051525	NFAT protein binding(GO:0051525)
0.1	0.2	GO:0035276	alcohol dehydrogenase activity, zinc-dependent(GO:0004024) ethanol binding(GO:0035276)
0.1	0.6	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1	0.3	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.1	0.3	GO:0009374	biotin binding(GO:0009374)
0.1	0.2	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1	1.1	GO:0071889	14-3-3 protein binding(GO:0071889)
0.1	0.5	GO:0039706	co-receptor binding(GO:0039706)
0.1	0.3	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.4	GO:0043208	glycosphingolipid binding(GO:0043208)
0.1	1.1	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.1	0.2	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	5.3	GO:0000149	SNARE binding(GO:0000149)
0.0	0.1	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.0	4.8	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	0.1	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0	2.8	GO:0035250	UDP-galactosyltransferase activity(GO:0035250)
0.0	1.0	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.0	0.6	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.2	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.2	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.4	GO:0001972	retinoic acid binding(GO:0001972)
0.0	0.2	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.0	0.2	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.0	0.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.2	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.3	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.7	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.0	0.2	GO:0046790	virion binding(GO:0046790)
0.0	0.5	GO:0016755	transferase activity, transferring amino-acyl groups(GO:0016755)
0.0	0.2	GO:0038191	neuropilin binding(GO:0038191)
0.0	0.1	GO:0019959	interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0034584	piRNA binding(GO:0034584)
0.0	0.1	GO:0035877	death effector domain binding(GO:0035877)
0.0	0.1	GO:0016453	acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.0	0.1	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	3.8	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.3	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.8	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.1	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.0	0.2	GO:0097602	cullin family protein binding(GO:0097602)
0.0	0.2	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.2	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0	0.2	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	2.7	GO:0003729	mRNA binding(GO:0003729)
0.0	0.1	GO:0019956	chemokine binding(GO:0019956)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0034046	poly(G) binding(GO:0034046)
0.0	0.1	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.0	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.5	GO:0015485	cholesterol binding(GO:0015485)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.9	GO:0051082	unfolded protein binding(GO:0051082)
0.0	0.3	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.2	GO:0016504	peptidase activator activity(GO:0016504)
0.0	0.0	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.3	GO:0005158	insulin receptor binding(GO:0005158)
0.0	1.0	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.1	GO:0031432	titin binding(GO:0031432)
0.0	0.0	GO:0004619	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0	0.0	GO:0016015	morphogen activity(GO:0016015)
0.0	0.9	GO:0030674	protein binding, bridging(GO:0030674)
0.0	0.0	GO:0030620	U2 snRNA binding(GO:0030620)
0.0	1.3	GO:0005179	hormone activity(GO:0005179)
0.0	0.0	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.3	PID EPHA FWDPATHWAY	EPHA forward signaling
0.1	1.0	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.1	1.5	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.1	2.4	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	3.9	PID LKB1 PATHWAY	LKB1 signaling events
0.1	3.6	PID FGF PATHWAY	FGF signaling pathway
0.1	0.5	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	2.2	NABA COLLAGENS	Genes encoding collagen proteins
0.0	0.7	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.0	0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	1.3	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	1.3	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	0.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.5	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	6.2	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	0.7	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.4	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.0	0.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.1	PID IGF1 PATHWAY	IGF1 pathway
0.0	0.1	PID FOXO PATHWAY	FoxO family signaling
0.0	0.1	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	4.1	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.3	4.0	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.2	2.5	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.2	2.6	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.1	1.4	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.1	1.0	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.1	1.1	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.1	1.6	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.1	2.5	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	1.3	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	0.8	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	0.6	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1	0.1	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1	0.4	REACTOME SIGNALLING BY NGF	Genes involved in Signalling by NGF
0.0	2.1	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	1.0	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	6.9	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	0.4	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	1.3	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.7	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.5	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.2	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.4	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.0	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0	1.6	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.0	0.3	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.3	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	0.2	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	0.3	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.3	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.2	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.2	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.0	0.5	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0	0.4	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
0.0	0.0	REACTOME PLATELET AGGREGATION PLUG FORMATION	Genes involved in Platelet Aggregation (Plug Formation)
0.0	0.3	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.1	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)