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ENCODE: ATAC-seq of different tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Hif1a

Z-value: 0.64

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Transcription factors associated with Hif1a

Gene Symbol	Gene ID	Gene Info
Hif1a Ensembl NCBI MGI UniProt	ENSMUSG00000021109.7	Hif1a

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Hif1a	chr12_73907701_73907880	114	0.960521	-0.65	8.4e-08	Click!
Hif1a	chr12_73907449_73907656	352	0.858120	-0.64	1.7e-07	Click!
Hif1a	chr12_73907945_73908301	219	0.925032	-0.60	1.4e-06	Click!
Hif1a	chr12_73908374_73908672	619	0.696810	-0.44	8.0e-04	Click!
Hif1a	chr12_73905175_73905337	2648	0.239489	-0.02	8.8e-01	Click!

Activity of the Hif1a motif across conditions

Conditions sorted by the z-value of the Hif1a motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr14_6756349_6757421	1.93	Gm3636	predicted gene 3636	14553	0.14
chr14_4018192_4019443	1.80	Gm5796	predicted gene 5796	5124	0.14
chr14_3332417_3333262	1.71	Gm2956	predicted gene 2956	212	0.91
chr14_4334095_4335404	1.64	2610042L04Rik	RIKEN cDNA 2610042L04 gene	14	0.97
chr14_3412209_3412992	1.61	Gm10409	predicted gene 10409	14	0.96
chr14_4726126_4727100	1.58	Gm3252	predicted gene 3252	162	0.93
chr14_6108337_6108836	1.54	Gm3468	predicted gene 3468	79	0.95
chr14_3809454_3810456	1.52	Gm3002	predicted gene 3002	119	0.95
chr11_102819100_102819714	1.50	Gjc1	gap junction protein, gamma 1	197	0.89
chr14_3571400_3572424	1.45	Gm3005	predicted gene 3005	111	0.96
chr14_7105202_7106057	1.43	Gm3696	predicted gene 3696	5008	0.15
chr1_179667564_179668717	1.42	Sccpdh	saccharopine dehydrogenase (putative)	70	0.98
chr7_4521231_4521527	1.38	Tnni3	troponin I, cardiac 3	812	0.37
chr14_7488010_7488824	1.34	Gm3752	predicted gene 3752	4655	0.16
chr14_4181957_4182899	1.34	Gm2974	predicted gene 2974	148	0.94
chr4_107830355_107830587	1.33	Lrp8os1	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, opposite strand 1	373	0.53
chr18_24714654_24714883	1.29	Fhod3	formin homology 2 domain containing 3	5323	0.18
chr14_7658268_7659211	1.29	Gm10128	predicted gene 10128	14767	0.16
chr14_3651827_3652389	1.26	Gm3020	predicted gene 3020	78	0.96
chr14_19584518_19585206	1.24	Gm2237	predicted gene 2237	273	0.84
chr14_6426499_6427300	1.23	Lamtor3-ps	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3, pseudogene	14417	0.14
chr8_111094195_111095226	1.20	Pdpr	pyruvate dehydrogenase phosphatase regulatory subunit	55	0.95
chr14_4498574_4499972	1.20	Gm3173	predicted gene 3173	15485	0.11
chr4_139637979_139638130	1.17	Mir7020	microRNA 7020	5988	0.15
chr8_15027100_15028701	1.16	Gm37844	predicted gene, 37844	522	0.44
chr9_87015281_87015918	1.13	Ripply2	ripply transcriptional repressor 2	37	0.97
chr14_5501458_5502048	1.12	Gm3488	predicted gene, 3488	79	0.95
chr7_120102194_120103051	1.11	Tmem159	transmembrane protein 159	132	0.86
chr11_47988672_47989535	1.09	Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	134	0.98
chr8_111144981_111146043	1.08	9430091E24Rik	RIKEN cDNA 9430091E24 gene	32	0.97
chr9_64110607_64110889	1.06	Lctl	lactase-like	6399	0.12
chr7_25010372_25010757	1.06	Atp1a3	ATPase, Na+/K+ transporting, alpha 3 polypeptide	4606	0.12
chr14_6287027_6287952	1.06	Gm3411	predicted gene 3411	239	0.89
chr6_148443752_148444889	1.03	Tmtc1	transmembrane and tetratricopeptide repeat containing 1	69	0.98
chr11_60104775_60106860	1.02	Rai1	retinoic acid induced 1	640	0.67
chr8_29219544_29220019	1.00	Unc5d	unc-5 netrin receptor D	145	0.97
chr5_74147781_74147946	0.99	A330058E17Rik	RIKEN cDNA A330058E17 gene	28187	0.11
chr14_5148821_5149378	0.99	Gm3317	predicted gene 3317	15436	0.11
chr2_144010017_144011636	0.97	Rrbp1	ribosome binding protein 1	437	0.82
chr14_7027128_7027881	0.95	Gm10406	predicted gene 10406	55	0.96
chr14_7174332_7174673	0.92	Gm3512	predicted gene 3512	31	0.97
chr5_25498778_25500023	0.90	Kmt2c	lysine (K)-specific methyltransferase 2C	617	0.62
chr1_22533152_22534195	0.87	Rims1	regulating synaptic membrane exocytosis 1	21144	0.28
chr3_135417369_135417520	0.86	Cisd2	CDGSH iron sulfur domain 2	5635	0.12
chrX_136666320_136667042	0.85	Tceal3	transcription elongation factor A (SII)-like 3	70	0.96
chr7_45234372_45235480	0.84	Cd37	CD37 antigen	532	0.49
chr7_143107542_143107900	0.84	Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	170	0.91
chr2_61812475_61812626	0.82	Tbr1	T-box brain gene 1	6277	0.19
chr14_6889264_6890534	0.81	Gm3667	predicted gene 3667	63	0.97
chr14_50061711_50061923	0.81	Gm37194	predicted gene, 37194	457	0.76
chr1_42698067_42698308	0.80	Pou3f3	POU domain, class 3, transcription factor 3	2419	0.19
chr1_42952543_42953742	0.79	Gpr45	G protein-coupled receptor 45	3	0.98
chr14_4855366_4855912	0.79	Gm3264	predicted gene 3264	63	0.96
chr8_69881901_69882713	0.79	Cilp2	cartilage intermediate layer protein 2	5380	0.11
chr9_114383017_114383329	0.79	Crtap	cartilage associated protein	4952	0.16
chr13_18947816_18948472	0.79	Amph	amphiphysin	61	0.97
chr3_110249839_110251122	0.78	C130013H08Rik	RIKEN cDNA C130013H08 gene	465	0.49
chr3_73053654_73054054	0.78	Slitrk3	SLIT and NTRK-like family, member 3	3089	0.24
chr5_37242202_37242734	0.77	Crmp1	collapsin response mediator protein 1	266	0.92
chr2_13010261_13011265	0.76	Gm37811	predicted gene, 37811	877	0.35
chr4_143211895_143213040	0.76	Prdm2	PR domain containing 2, with ZNF domain	238	0.9
chr12_33957808_33958154	0.75	Twist1	twist basic helix-loop-helix transcription factor 1	310	0.91
chr13_116297452_116297610	0.75	Isl1	ISL1 transcription factor, LIM/homeodomain	5820	0.25
chr12_112781968_112782119	0.75	Ahnak2	AHNAK nucleoprotein 2	1032	0.36
chr9_72924923_72926161	0.74	Pygo1	pygopus 1	103	0.93
chr15_95702329_95702480	0.74	Gm8843	predicted gene 8843	12789	0.16
chr13_48966851_48968700	0.74	Fam120a	family with sequence similarity 120, member A	242	0.95
chr10_78747019_78747870	0.73	Gm30400	predicted gene, 30400	285	0.85
chr1_85325328_85325596	0.72	Gm16025	predicted gene 16025	1267	0.31
chr2_22895114_22896094	0.72	Pdss1	prenyl (solanesyl) diphosphate synthase, subunit 1	9	0.63
chrX_110814525_110815208	0.71	Pou3f4	POU domain, class 3, transcription factor 4	586	0.77
chr11_5788301_5789276	0.71	Dbnl	drebrin-like	258	0.86
chr9_8003315_8004975	0.71	Yap1	yes-associated protein 1	245	0.79
chr14_5460033_5460567	0.69	Gm3194	predicted gene 3194	4833	0.14
chr9_100095718_100095869	0.68	4930519F24Rik	RIKEN cDNA 4930519F24 gene	72145	0.1
chr9_90163003_90164118	0.68	Adamts7	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7	334	0.85
chr17_14279299_14279731	0.68	Smoc2	SPARC related modular calcium binding 2	9	0.98
chr14_5812521_5813051	0.67	Gm3383	predicted gene 3383	4804	0.13
chr4_101419063_101420491	0.66	Ak4	adenylate kinase 4	44	0.97
chr8_84742133_84743295	0.66	G430095P16Rik	RIKEN cDNA G430095P16 gene	19707	0.09
chr7_35554990_35556314	0.65	B230322F03Rik	RIKEN cDNA B230322F03 gene	285	0.62
chr11_121259259_121260714	0.65	Foxk2	forkhead box K2	4	0.96
chr5_142367069_142368113	0.65	Foxk1	forkhead box K1	33906	0.18
chr17_43629678_43630114	0.64	Tdrd6	tudor domain containing 6	370	0.84
chr15_88733665_88734619	0.64	Brd1	bromodomain containing 1	88	0.97
chr7_18957517_18958673	0.63	Nanos2	nanos C2HC-type zinc finger 2	29305	0.06
chr15_57745156_57745804	0.63	9330154K18Rik	RIKEN cDNA 9330154K18 gene	6814	0.22
chr17_27555089_27556137	0.63	Hmga1	high mobility group AT-hook 1	884	0.27
chr13_55471184_55472974	0.62	Mir6944	microRNA 6944	5697	0.08
chr10_85102468_85103421	0.61	Tmem263	transmembrane protein 263	201	0.74
chr16_91223532_91223683	0.61	Gm49614	predicted gene, 49614	681	0.54
chr4_136637166_136638197	0.61	Gm37583	predicted gene, 37583	1901	0.22
chr14_5070417_5071423	0.61	Gm8281	predicted gene, 8281	120	0.95
chr3_80800657_80801686	0.60	Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	1408	0.52
chr5_71657445_71657639	0.60	Gabra4	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4	278	0.73
chr2_75246191_75246393	0.60	2600014E21Rik	RIKEN cDNA 2600014E21 gene	2108	0.3
chr1_33907825_33908362	0.60	Dst	dystonin	132	0.68
chr18_25504451_25505014	0.58	Celf4	CUGBP, Elav-like family member 4	3493	0.34
chr13_99516425_99517155	0.58	Gm26559	predicted gene, 26559	161	0.62
chr18_34006863_34007553	0.57	Epb41l4a	erythrocyte membrane protein band 4.1 like 4a	242	0.92
chr8_35328966_35329165	0.56	Ppp1r3b	protein phosphatase 1, regulatory subunit 3B	46674	0.11
chr14_65423658_65423809	0.56	Pnoc	prepronociceptin	1427	0.44
chr16_34921371_34921807	0.56	Mylk	myosin, light polypeptide kinase	8753	0.19
chr11_3331774_3332581	0.56	Pik3ip1	phosphoinositide-3-kinase interacting protein 1	68	0.93
chr14_122490496_122491140	0.56	Gm10837	predicted gene 10837	232	0.87
chr2_153258876_153259060	0.56	Pofut1	protein O-fucosyltransferase 1	1396	0.34
chr3_57574902_57575246	0.56	Wwtr1	WW domain containing transcription regulator 1	754	0.61
chr9_107400062_107400379	0.56	Cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	151	0.93
chr10_80225959_80227288	0.55	Pwwp3a	PWWP domain containing 3A, DNA repair factor	32	0.94
chr2_152143351_152143985	0.55	Tcf15	transcription factor 15	107	0.96
chr12_117533503_117534508	0.55	Rapgef5	Rap guanine nucleotide exchange factor (GEF) 5	117	0.97
chr1_181352151_181352477	0.54	Cnih3	cornichon family AMPA receptor auxiliary protein 3	314	0.88
chr11_7055619_7056056	0.54	Adcy1	adenylate cyclase 1	7652	0.26
chr3_129204151_129204986	0.54	Pitx2	paired-like homeodomain transcription factor 2	621	0.7
chr7_46179909_46180259	0.53	Abcc8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	51	0.96
chr11_51855495_51856955	0.53	Jade2	jade family PHD finger 2	900	0.57
chr6_39256581_39257096	0.53	Gm26008	predicted gene, 26008	9104	0.16
chr7_6171760_6172680	0.53	Zfp444	zinc finger protein 444	6	0.95
chrX_157613038_157613189	0.52	Gm15173	predicted gene 15173	8	0.96
chr18_65430370_65431071	0.52	Malt1	MALT1 paracaspase	218	0.9
chr5_136038932_136039111	0.52	Upk3b	uroplakin 3B	525	0.64
chr13_71558486_71558841	0.52	Gm47811	predicted gene, 47811	66311	0.11
chr10_24479227_24479575	0.52	Gm15271	predicted gene 15271	31911	0.15
chr12_45563232_45563656	0.52	Gm48517	predicted gene, 48517	9843	0.27
chr2_152093402_152093892	0.52	Srxn1	sulfiredoxin 1 homolog (S. cerevisiae)	11869	0.13
chr3_101109480_101110654	0.51	Ptgfrn	prostaglandin F2 receptor negative regulator	211	0.94
chr1_59376261_59376435	0.51	Gm29016	predicted gene 29016	2582	0.29
chr9_114528016_114528485	0.51	C130032M10Rik	RIKEN cDNA C130032M10 gene	12553	0.16
chr7_5080037_5080839	0.50	Epn1	epsin 1	145	0.87
chr2_37775771_37775969	0.50	Crb2	crumbs family member 2	379	0.88
chr17_55445138_55445530	0.49	St6gal2	beta galactoside alpha 2,6 sialyltransferase 2	48	0.98
chr12_108794058_108794786	0.49	Yy1	YY1 transcription factor	1449	0.23
chr17_28271837_28272180	0.49	Ppard	peroxisome proliferator activator receptor delta	111	0.94
chr11_82388737_82388922	0.49	Tmem132e	transmembrane protein 132E	71	0.97
chr2_156614281_156614628	0.48	Dlgap4	DLG associated protein 4	749	0.35
chr7_138909400_138910240	0.48	Bnip3	BCL2/adenovirus E1B interacting protein 3	301	0.83
chr6_80622673_80623041	0.48	Gm44231	predicted gene, 44231	32172	0.23
chr6_48629216_48629950	0.48	AI854703	expressed sequence AI854703	1648	0.16
chr12_20415451_20415611	0.47	Gm49929	predicted gene, 49929	406	0.77
chr8_117157446_117158085	0.47	Gan	giant axonal neuropathy	370	0.87
chr2_48538627_48539050	0.47	Gm13481	predicted gene 13481	81593	0.1
chr18_35920048_35920506	0.46	Gm50405	predicted gene, 50405	3018	0.15
chr14_122463926_122464344	0.46	Zic5	zinc finger protein of the cerebellum 5	1542	0.26
chr4_154329867_154330297	0.46	Prdm16	PR domain containing 16	4770	0.18
chr10_80398762_80400128	0.46	Mbd3	methyl-CpG binding domain protein 3	23	0.93
chr13_73265452_73265676	0.46	Irx4	Iroquois homeobox 4	5067	0.17
chr6_72898945_72900607	0.46	Kcmf1	potassium channel modulatory factor 1	73	0.97
chr4_49844763_49845632	0.45	Grin3a	glutamate receptor ionotropic, NMDA3A	352	0.92
chr18_40256699_40257075	0.45	Kctd16	potassium channel tetramerisation domain containing 16	75	0.96
chr4_82513118_82513685	0.45	Gm11266	predicted gene 11266	5385	0.22
chr2_147188117_147188295	0.45	6430503K07Rik	RIKEN cDNA 6430503K07 gene	782	0.52
chr13_94868641_94869006	0.45	Otp	orthopedia homeobox	6779	0.21
chr8_57354026_57354218	0.45	5033428I22Rik	RIKEN cDNA 5033428I22 gene	13322	0.13
chr7_28294529_28294993	0.44	Dll3	delta like canonical Notch ligand 3	280	0.78
chr7_49088814_49088965	0.44	Gm32849	predicted gene, 32849	3806	0.23
chr2_79585158_79585309	0.44	Itprid2	ITPR interacting domain containing 2	50119	0.16
chr12_102729973_102730175	0.43	Gm28373	predicted gene 28373	2741	0.12
chr19_24031055_24031408	0.43	Fam189a2	family with sequence similarity 189, member A2	212	0.93
chr9_80332183_80332515	0.42	Myo6	myosin VI	25435	0.21
chr6_99726441_99726592	0.42	Prok2	prokineticin 2	124	0.9
chr9_107231249_107231435	0.42	Dock3	dedicator of cyto-kinesis 3	240	0.6
chr5_110652819_110653593	0.42	Noc4l	NOC4 like	53	0.74
chr14_69390979_69391250	0.42	Gm21451	predicted gene, 21451	260	0.86
chr18_46109567_46109759	0.42	Gm38337	predicted gene, 38337	3596	0.27
chr14_33319515_33320532	0.41	Arhgap22	Rho GTPase activating protein 22	320	0.89
chr6_119107307_119108229	0.41	Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	207	0.96
chr4_138395338_138395489	0.41	AB041806	hypothetical protein, MNCb-2457	215	0.85
chr12_18609538_18611003	0.40	Gm48398	predicted gene, 48398	114	0.96
chr13_54765971_54766190	0.40	Sncb	synuclein, beta	17	0.96
chrX_162759829_162760925	0.40	Rbbp7	retinoblastoma binding protein 7, chromatin remodeling factor	25	0.97
chr9_8544024_8544863	0.40	Trpc6	transient receptor potential cation channel, subfamily C, member 6	200	0.96
chr1_177448201_177448585	0.40	Zbtb18	zinc finger and BTB domain containing 18	2572	0.22
chr16_14445264_14445415	0.40	Abcc1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	15669	0.17
chr5_28460507_28460658	0.40	9530036O11Rik	RIKEN cDNA 9530036O11Rik	2308	0.3
chr13_71963383_71964045	0.40	Irx1	Iroquois homeobox 1	9	0.98
chr17_83954879_83955189	0.39	Gm35229	predicted gene, 35229	1214	0.31
chr9_53705535_53706804	0.39	Rab39	RAB39, member RAS oncogene family	63	0.96
chr13_17993545_17993782	0.39	Yae1d1	Yae1 domain containing 1	314	0.75
chr8_111739568_111739875	0.39	Bcar1	breast cancer anti-estrogen resistance 1	4088	0.22
chr14_69609343_69609518	0.39	Loxl2	lysyl oxidase-like 2	48	0.96
chr10_81392422_81392592	0.38	Smim24	small integral membrane protein 24	544	0.44
chr17_56626470_56627486	0.38	Lonp1	lon peptidase 1, mitochondrial	91	0.92
chr1_64735773_64736678	0.38	Gm38058	predicted gene, 38058	15	0.96
chr8_90907824_90909226	0.38	Chd9	chromodomain helicase DNA binding protein 9	89	0.52
chr7_37769955_37770699	0.38	Zfp536	zinc finger protein 536	365	0.9
chr15_38298982_38300199	0.38	Klf10	Kruppel-like factor 10	205	0.91
chr7_101821788_101822627	0.38	Phox2a	paired-like homeobox 2a	1461	0.21
chr1_120602158_120602362	0.37	En1	engrailed 1	158	0.96
chr6_89361531_89362433	0.37	Plxna1	plexin A1	638	0.7
chr12_55598801_55599099	0.37	Insm2	insulinoma-associated 2	477	0.8
chr7_109703238_109703866	0.37	Denn2b	DENN domain containing 2B	53	0.6
chr9_92541870_92542582	0.37	Plod2	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	3	0.92
chr5_148398815_148400002	0.37	Slc7a1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	383	0.89
chr5_129724468_129725740	0.36	Nipsnap2	nipsnap homolog 2	3	0.95
chr16_92357164_92357320	0.36	Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	1632	0.26
chr11_117864041_117864389	0.36	Tmem235	transmembrane protein 235	3463	0.12
chr17_69417243_69417687	0.36	C030034I22Rik	RIKEN cDNA C030034I22 gene	4	0.97
chr1_90797381_90797532	0.36	Col6a3	collagen, type VI, alpha 3	2735	0.29
chr1_25829654_25830461	0.36	Adgrb3	adhesion G protein-coupled receptor B3	350	0.61
chr8_106893544_106894153	0.35	Utp4	UTP4 small subunit processome component	197	0.4

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hif1a

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:0097623	potassium ion export across plasma membrane(GO:0097623)
0.3	1.1	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis(GO:0003253)
0.2	0.6	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2	0.5	GO:0038026	reelin-mediated signaling pathway(GO:0038026)
0.2	0.5	GO:0033505	floor plate morphogenesis(GO:0033505)
0.2	0.6	GO:0001923	B-1 B cell differentiation(GO:0001923)
0.2	0.2	GO:0072025	distal convoluted tubule development(GO:0072025) DCT cell differentiation(GO:0072069) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) metanephric DCT cell differentiation(GO:0072240)
0.1	0.9	GO:0072257	metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1	0.6	GO:0061743	motor learning(GO:0061743)
0.1	0.3	GO:0021564	vagus nerve development(GO:0021564)
0.1	0.4	GO:0032025	response to cobalt ion(GO:0032025)
0.1	0.2	GO:0033122	negative regulation of purine nucleotide catabolic process(GO:0033122)
0.1	0.3	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1	0.4	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
0.1	0.8	GO:2001054	negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.1	0.3	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1	1.3	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.1	0.4	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.1	1.0	GO:0021859	pyramidal neuron differentiation(GO:0021859)
0.1	0.2	GO:0071655	macrophage colony-stimulating factor production(GO:0036301) granulocyte colony-stimulating factor production(GO:0071611) regulation of granulocyte colony-stimulating factor production(GO:0071655) regulation of macrophage colony-stimulating factor production(GO:1901256)
0.1	0.5	GO:0043415	positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.1	0.5	GO:0014028	notochord formation(GO:0014028)
0.1	0.3	GO:0045041	protein import into mitochondrial intermembrane space(GO:0045041)
0.1	0.4	GO:2001023	regulation of response to drug(GO:2001023)
0.1	0.3	GO:0007386	compartment pattern specification(GO:0007386)
0.1	0.5	GO:0060024	rhythmic synaptic transmission(GO:0060024)
0.1	0.2	GO:0036515	serotonergic neuron axon guidance(GO:0036515)
0.1	0.2	GO:0035262	gonad morphogenesis(GO:0035262)
0.1	0.2	GO:2000302	positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.1	0.3	GO:0015822	ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.1	0.2	GO:0060266	negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1	0.2	GO:0010643	cell communication by chemical coupling(GO:0010643)
0.1	0.2	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.3	GO:0018103	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1	0.3	GO:1903011	negative regulation of bone development(GO:1903011)
0.1	0.4	GO:0003348	cardiac endothelial cell differentiation(GO:0003348)
0.1	0.4	GO:0090383	phagosome acidification(GO:0090383)
0.1	0.7	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1	0.2	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.1	0.3	GO:0019230	proprioception(GO:0019230)
0.1	0.3	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1	0.2	GO:0060448	dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.1	0.2	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902)
0.1	0.3	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.2	GO:2000686	regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.1	0.3	GO:0051612	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1	0.2	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1	0.2	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1	0.2	GO:2001206	positive regulation of osteoclast development(GO:2001206)
0.1	0.4	GO:0051639	actin filament network formation(GO:0051639)
0.1	0.8	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.1	0.2	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.1	0.8	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1	0.6	GO:0051014	actin filament severing(GO:0051014)
0.1	0.1	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.1	0.7	GO:0061029	eyelid development in camera-type eye(GO:0061029)
0.1	0.2	GO:0007296	vitellogenesis(GO:0007296)
0.1	0.3	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.1	0.2	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.1	0.2	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1	0.2	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1	0.4	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1	0.7	GO:0046033	AMP metabolic process(GO:0046033)
0.1	0.4	GO:0008090	retrograde axonal transport(GO:0008090)
0.1	0.5	GO:0042135	neurotransmitter catabolic process(GO:0042135)
0.0	0.2	GO:0042297	vocal learning(GO:0042297) imitative learning(GO:0098596) learned vocalization behavior or vocal learning(GO:0098598)
0.0	0.2	GO:0060480	lung goblet cell differentiation(GO:0060480)
0.0	0.1	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.1	GO:0035799	ureter maturation(GO:0035799)
0.0	0.5	GO:0006744	ubiquinone biosynthetic process(GO:0006744)
0.0	0.2	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.2	GO:1902866	regulation of retina development in camera-type eye(GO:1902866)
0.0	0.1	GO:2001016	positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0	0.2	GO:0045541	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.4	GO:0006054	N-acetylneuraminate metabolic process(GO:0006054)
0.0	0.8	GO:0008340	determination of adult lifespan(GO:0008340)
0.0	0.2	GO:0002159	desmosome assembly(GO:0002159)
0.0	0.1	GO:1901873	regulation of post-translational protein modification(GO:1901873) negative regulation of post-translational protein modification(GO:1901874)
0.0	0.8	GO:0007289	spermatid nucleus differentiation(GO:0007289)
0.0	0.2	GO:0019478	D-amino acid catabolic process(GO:0019478)
0.0	0.2	GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0	0.0	GO:0048852	diencephalon morphogenesis(GO:0048852)
0.0	0.2	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.2	GO:0003357	noradrenergic neuron differentiation(GO:0003357)
0.0	0.4	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.6	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0	0.2	GO:0061339	establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.0	0.4	GO:1904321	response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0	0.2	GO:0021979	hypothalamus cell differentiation(GO:0021979)
0.0	0.7	GO:0048488	synaptic vesicle endocytosis(GO:0048488)
0.0	0.2	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
0.0	0.1	GO:0071476	cellular hypotonic response(GO:0071476)
0.0	0.2	GO:0060120	auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0	0.3	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.5	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.1	GO:0006537	glutamate biosynthetic process(GO:0006537)
0.0	1.0	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.0	0.3	GO:1900121	negative regulation of receptor binding(GO:1900121)
0.0	0.1	GO:0048023	positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.2	GO:0006044	N-acetylglucosamine metabolic process(GO:0006044)
0.0	0.2	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0	0.1	GO:0021698	cerebellar cortex structural organization(GO:0021698)
0.0	0.0	GO:1902302	regulation of potassium ion export(GO:1902302)
0.0	0.1	GO:0006382	adenosine to inosine editing(GO:0006382)
0.0	0.1	GO:0021780	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0	0.2	GO:0034651	cortisol biosynthetic process(GO:0034651)
0.0	0.4	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.2	GO:0061042	vascular wound healing(GO:0061042)
0.0	0.1	GO:0019388	galactose catabolic process(GO:0019388)
0.0	0.1	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.2	GO:0031145	anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0	0.1	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.0	0.1	GO:2001197	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0	0.2	GO:0060013	righting reflex(GO:0060013)
0.0	0.2	GO:0019348	dolichol metabolic process(GO:0019348)
0.0	0.4	GO:0071800	podosome assembly(GO:0071800)
0.0	0.1	GO:0035788	cell migration involved in kidney development(GO:0035787) cell migration involved in metanephros development(GO:0035788) metanephric mesenchymal cell migration(GO:0035789) positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) regulation of metanephric mesenchymal cell migration(GO:2000589) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0	0.1	GO:0010529	regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0	0.2	GO:2000637	positive regulation of gene silencing by miRNA(GO:2000637)
0.0	0.4	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	0.1	GO:1900045	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.4	GO:0046688	response to copper ion(GO:0046688)
0.0	0.1	GO:0010288	response to lead ion(GO:0010288)
0.0	0.2	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.1	GO:0050915	sensory perception of sour taste(GO:0050915)
0.0	0.4	GO:0015813	L-glutamate transport(GO:0015813)
0.0	0.0	GO:0097694	establishment of RNA localization to telomere(GO:0097694)
0.0	0.4	GO:0046325	negative regulation of glucose import(GO:0046325)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.2	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:1903689	regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.0	0.0	GO:0046098	guanine metabolic process(GO:0046098)
0.0	0.2	GO:0035879	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0	0.2	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.1	GO:0042796	snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0	0.1	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.0	0.1	GO:0071420	cellular response to histamine(GO:0071420)
0.0	0.1	GO:0021942	radial glia guided migration of Purkinje cell(GO:0021942)
0.0	0.2	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.0	0.1	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.3	GO:0034389	lipid particle organization(GO:0034389)
0.0	0.2	GO:0006415	translational termination(GO:0006415)
0.0	0.0	GO:0003219	cardiac right ventricle formation(GO:0003219)
0.0	0.6	GO:0009268	response to pH(GO:0009268)
0.0	0.1	GO:2000653	regulation of genetic imprinting(GO:2000653)
0.0	0.0	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0	0.4	GO:0042417	dopamine metabolic process(GO:0042417)
0.0	0.2	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.1	GO:0072656	maintenance of protein location in mitochondrion(GO:0072656)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0021984	adenohypophysis development(GO:0021984)
0.0	0.2	GO:0045956	positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0	0.0	GO:0043622	cortical microtubule organization(GO:0043622)
0.0	0.6	GO:0019933	cAMP-mediated signaling(GO:0019933)
0.0	0.0	GO:0021773	striatal medium spiny neuron differentiation(GO:0021773)
0.0	0.0	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915)
0.0	0.1	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.4	GO:0034605	cellular response to heat(GO:0034605)
0.0	0.1	GO:1900262	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0	0.0	GO:0060155	platelet dense granule organization(GO:0060155)
0.0	0.0	GO:0033088	negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.1	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.1	GO:0071043	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.2	GO:0071475	cellular response to salt stress(GO:0071472) cellular hyperosmotic salinity response(GO:0071475)
0.0	0.1	GO:0072498	embryonic skeletal joint development(GO:0072498)
0.0	0.0	GO:0006848	pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.0	GO:1903232	melanosome assembly(GO:1903232)
0.0	0.0	GO:0001807	regulation of type IV hypersensitivity(GO:0001807)
0.0	0.1	GO:0043545	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.1	GO:0021546	rhombomere development(GO:0021546)
0.0	0.1	GO:0099515	actin filament-based transport(GO:0099515)
0.0	0.0	GO:0098903	regulation of membrane repolarization during action potential(GO:0098903)
0.0	0.1	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.1	GO:0006450	regulation of translational fidelity(GO:0006450)
0.0	0.2	GO:0031116	positive regulation of microtubule polymerization(GO:0031116)
0.0	0.1	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0	0.0	GO:0044838	cell quiescence(GO:0044838)
0.0	0.1	GO:0014721	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.0	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.0	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.0	0.1	GO:0048012	hepatocyte growth factor receptor signaling pathway(GO:0048012)
0.0	0.0	GO:0070100	negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.1	GO:0010225	response to UV-C(GO:0010225)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.0	GO:0086011	membrane repolarization during action potential(GO:0086011)
0.0	0.0	GO:0042505	tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525)
0.0	0.2	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.0	GO:0018242	protein O-linked glycosylation via serine(GO:0018242)
0.0	0.1	GO:0071257	cellular response to electrical stimulus(GO:0071257)
0.0	0.2	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
0.0	0.0	GO:0044845	cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506) cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) chain elongation of O-linked mannose residue(GO:0044845) cellular component macromolecule biosynthetic process(GO:0070589)
0.0	0.0	GO:1900194	negative regulation of oocyte maturation(GO:1900194)
0.0	0.1	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.1	GO:0071763	nuclear membrane organization(GO:0071763)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.1	0.4	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.1	0.6	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1	0.4	GO:0044308	axonal spine(GO:0044308)
0.1	0.3	GO:0036194	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1	0.3	GO:0030689	Noc complex(GO:0030689)
0.1	1.3	GO:0005614	interstitial matrix(GO:0005614)
0.1	0.4	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.1	0.6	GO:0005861	troponin complex(GO:0005861)
0.1	0.2	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	1.3	GO:0005922	connexon complex(GO:0005922)
0.1	0.9	GO:0042589	zymogen granule membrane(GO:0042589)
0.1	0.5	GO:0097542	ciliary tip(GO:0097542)
0.1	0.4	GO:0036057	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1	0.2	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1	0.2	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1	0.2	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.1	0.2	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1	0.4	GO:0044666	MLL3/4 complex(GO:0044666)
0.0	0.9	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	0.2	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.6	GO:0032279	asymmetric synapse(GO:0032279)
0.0	0.1	GO:0097512	cardiac myofibril(GO:0097512)
0.0	0.7	GO:0002102	podosome(GO:0002102)
0.0	0.5	GO:0033391	chromatoid body(GO:0033391)
0.0	0.3	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	0.4	GO:0005921	gap junction(GO:0005921)
0.0	0.2	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.0	0.2	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.6	GO:1902710	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0	0.7	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	0.2	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.8	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.1	GO:0035363	histone locus body(GO:0035363)
0.0	0.4	GO:0005865	striated muscle thin filament(GO:0005865)
0.0	0.3	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.1	GO:1990423	RZZ complex(GO:1990423)
0.0	0.2	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	0.1	GO:0048476	Holliday junction resolvase complex(GO:0048476)
0.0	0.6	GO:0031941	filamentous actin(GO:0031941)
0.0	0.3	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.6	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	1.1	GO:0042734	presynaptic membrane(GO:0042734)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	1.5	GO:0043195	terminal bouton(GO:0043195)
0.0	0.1	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.1	GO:0044327	dendritic spine head(GO:0044327)
0.0	0.1	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0	0.0	GO:0005956	protein kinase CK2 complex(GO:0005956)
0.0	0.1	GO:0097651	phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0	0.1	GO:0042567	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.1	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.1	GO:0097452	GAIT complex(GO:0097452)
0.0	0.2	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0097449	astrocyte projection(GO:0097449)
0.0	0.1	GO:0031390	Ctf18 RFC-like complex(GO:0031390)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.0	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.3	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.4	GO:0001772	immunological synapse(GO:0001772)
0.0	0.0	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.0	GO:0031502	dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0	0.0	GO:0070110	ciliary neurotrophic factor receptor complex(GO:0070110)
0.0	0.4	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0045180	basal cortex(GO:0045180)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.3	1.0	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.2	0.4	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2	0.5	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.2	0.5	GO:0030172	troponin C binding(GO:0030172)
0.1	0.9	GO:0003680	AT DNA binding(GO:0003680)
0.1	0.5	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1	0.4	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	0.4	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1	0.6	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1	1.3	GO:0005243	gap junction channel activity(GO:0005243)
0.1	0.4	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.1	0.6	GO:0004017	adenylate kinase activity(GO:0004017)
0.1	0.3	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.1	0.2	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.2	GO:0042296	ISG15 transferase activity(GO:0042296)
0.1	0.4	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.1	0.2	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.1	0.9	GO:0031005	filamin binding(GO:0031005)
0.1	0.2	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.1	0.3	GO:0015189	arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.1	0.2	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.1	0.2	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.1	0.2	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.1	0.2	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.1	0.3	GO:0001515	opioid peptide activity(GO:0001515)
0.1	0.4	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.1	0.2	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0	0.5	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.4	GO:0031545	peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.1	GO:0004104	cholinesterase activity(GO:0004104)
0.0	1.4	GO:0043738	N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.0	0.2	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.5	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.3	GO:0043495	protein anchor(GO:0043495)
0.0	0.2	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.3	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.3	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.2	GO:0035241	protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0	0.2	GO:0008079	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.3	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.3	GO:0043912	D-lysine oxidase activity(GO:0043912)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.2	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.2	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.4	GO:0070679	inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0	0.7	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.2	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.2	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.6	GO:0004890	GABA-A receptor activity(GO:0004890)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.5	GO:0005112	Notch binding(GO:0005112)
0.0	0.9	GO:0050699	WW domain binding(GO:0050699)
0.0	0.2	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.3	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.3	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.2	GO:0043338	CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.4	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0	0.3	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.0	0.1	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0	0.1	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0	0.4	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.1	GO:0004565	beta-galactosidase activity(GO:0004565)
0.0	0.1	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.2	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.8	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.0	0.2	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.3	GO:0005542	folic acid binding(GO:0005542)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0031014	troponin T binding(GO:0031014)
0.0	0.2	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.0	0.1	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.4	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.1	GO:0032027	myosin light chain binding(GO:0032027)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0031748	D1 dopamine receptor binding(GO:0031748)
0.0	0.0	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0	0.0	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0004445	inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0	0.1	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.4	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0098988	G-protein coupled glutamate receptor activity(GO:0098988)
0.0	0.1	GO:0052832	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.0	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.3	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.3	GO:0071837	HMG box domain binding(GO:0071837)
0.0	0.2	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0008865	fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0	0.2	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.1	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.0	0.2	GO:0035198	miRNA binding(GO:0035198)
0.0	0.0	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.0	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.0	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0102345	3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.2	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.3	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	0.1	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.0	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0	0.2	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.0	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.6	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.8	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.7	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.7	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.9	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.7	PID ERBB4 PATHWAY	ErbB4 signaling events
0.4	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.4	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.8	PID NOTCH PATHWAY	Notch signaling pathway
1.0	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.6	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.6	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.1	0.3	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1	1.0	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.1	1.2	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	0.6	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.4	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.2	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.5	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.3	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.2	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.5	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.5	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	0.8	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.1	REACTOME MRNA PROCESSING	Genes involved in mRNA Processing
0.0	0.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.7	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.2	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.9	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.9	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	0.5	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.2	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.0	0.3	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.7	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.2	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.4	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.2	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.6	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.0	0.1	REACTOME REGULATION OF INSULIN SECRETION	Genes involved in Regulation of Insulin Secretion
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.2	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0	0.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.0	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.0	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.1	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0	0.1	REACTOME SIGNAL TRANSDUCTION BY L1	Genes involved in Signal transduction by L1
0.0	0.2	REACTOME AMYLOIDS	Genes involved in Amyloids