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ENCODE: ATAC-seq of different tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Zbtb49

Z-value: 0.75

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Transcription factors associated with Zbtb49

Gene Symbol	Gene ID	Gene Info
Zbtb49 Ensembl NCBI MGI UniProt	ENSMUSG00000029127.9	Zbtb49

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Zbtb49	chr5_38197525_38197734	6168	0.161409	0.43	1.1e-03	Click!
Zbtb49	chr5_38219903_38220668	128	0.577877	-0.10	4.7e-01	Click!

Activity of the Zbtb49 motif across conditions

Conditions sorted by the z-value of the Zbtb49 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_99351180_99351446	4.73	Serpinh1	serine (or cysteine) peptidase inhibitor, clade H, member 1	1684	0.3
chr16_52134647_52134858	3.92	Cblb	Casitas B-lineage lymphoma b	17774	0.23
chr5_51899713_51899923	3.61	Gm42617	predicted gene 42617	6604	0.18
chr1_38835547_38836894	3.53	Lonrf2	LON peptidase N-terminal domain and ring finger 2	154	0.95
chr2_181156709_181156878	3.48	Eef1a2	eukaryotic translation elongation factor 1 alpha 2	221	0.88
chr8_4492910_4494136	3.37	Cers4	ceramide synthase 4	2	0.97
chr11_34348265_34348533	3.18	Insyn2b	inhibitory synaptic factor family member 2B	33577	0.16
chr2_49671811_49671963	3.16	Gm13525	predicted gene 13525	8612	0.24
chr14_34892319_34892570	3.14	Mir346	microRNA 346	2165	0.38
chr13_84752343_84752734	3.09	Gm26913	predicted gene, 26913	61597	0.15
chr4_105133429_105133580	2.97	Prkaa2	protein kinase, AMP-activated, alpha 2 catalytic subunit	23614	0.21
chr1_97848651_97848869	2.92	Pam	peptidylglycine alpha-amidating monooxygenase	7879	0.21
chr12_27357279_27357647	2.75	Sox11	SRY (sex determining region Y)-box 11	14889	0.28
chr17_24736037_24737110	2.74	Msrb1	methionine sulfoxide reductase B1	69	0.91
chr8_15012305_15012539	2.44	Kbtbd11	kelch repeat and BTB (POZ) domain containing 11	1116	0.34
chr4_95966590_95967315	2.41	9530080O11Rik	RIKEN cDNA 9530080O11 gene	83	0.77
chr19_59043649_59043837	2.36	Shtn1	shootin 1	5458	0.22
chr4_24430547_24430742	2.35	Gm27243	predicted gene 27243	246	0.94
chr4_130865591_130865782	2.28	Gm22660	predicted gene, 22660	7806	0.15
chr18_12570169_12570328	2.11	Gm22340	predicted gene, 22340	8289	0.17
chr19_7267088_7267830	2.09	Rcor2	REST corepressor 2	134	0.92
chr2_38132297_38132687	2.09	Gm44291	predicted gene, 44291	25196	0.17
chr8_124910029_124910183	2.08	Sprtn	SprT-like N-terminal domain	8291	0.12
chr1_56726194_56726492	2.06	Hsfy2	heat shock transcription factor, Y-linked 2	88908	0.09
chr1_109982807_109983363	2.05	Cdh7	cadherin 7, type 2	79	0.99
chr12_29547825_29548188	2.05	Myt1l	myelin transcription factor 1-like	12784	0.23
chr5_114743003_114743280	1.94	Git2	GIT ArfGAP 2	727	0.5
chr16_22119053_22119204	1.84	Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	2108	0.32
chr18_23517169_23517333	1.82	Dtna	dystrobrevin alpha	15508	0.28
chr1_132200708_132201234	1.81	Lemd1	LEM domain containing 1	8	0.96
chr1_83408010_83408453	1.78	Sphkap	SPHK1 interactor, AKAP domain containing	31	0.98
chr6_51848127_51848460	1.77	Skap2	src family associated phosphoprotein 2	23636	0.22
chr1_87175818_87176082	1.77	Prss56	protease, serine 56	7363	0.1
chr10_84060700_84061314	1.77	Gm37908	predicted gene, 37908	751	0.67
chr8_110716047_110716632	1.77	Mtss2	MTSS I-BAR domain containing 2	5137	0.18
chrX_77509141_77509684	1.76	Tbl1x	transducin (beta)-like 1 X-linked	1601	0.45
chr12_99474171_99474502	1.73	Foxn3	forkhead box N3	24239	0.17
chr4_149255354_149255580	1.68	Kif1b	kinesin family member 1B	7488	0.18
chr1_43358317_43358468	1.67	Gm29041	predicted gene 29041	51192	0.12
chr4_150769131_150769447	1.60	Gm13049	predicted gene 13049	56444	0.1
chr14_34080426_34080774	1.58	Gm49129	predicted gene, 49129	4153	0.11
chr12_29938165_29938369	1.56	Pxdn	peroxidasin	217	0.96
chr4_91244667_91244900	1.56	Elavl2	ELAV like RNA binding protein 1	9799	0.27
chr6_54507929_54508080	1.56	Scrn1	secernin 1	1357	0.41
chr8_12105221_12105384	1.52	B020031H02Rik	RIKEN cDNA B020031H02 gene	156963	0.03
chr17_56467426_56468397	1.52	Ptprs	protein tyrosine phosphatase, receptor type, S	5695	0.16
chr6_18446901_18447365	1.47	Gm26233	predicted gene, 26233	2207	0.27
chr7_49266538_49266689	1.46	Nav2	neuron navigator 2	19768	0.21
chr19_10041145_10042475	1.46	Fads3	fatty acid desaturase 3	78	0.96
chr3_127705467_127706232	1.45	1500005C15Rik	RIKEN cDNA 1500005C15 gene	11178	0.11
chr13_24625131_24625340	1.44	Ripor2	RHO family interacting cell polarization regulator 2	10608	0.19
chrX_69666247_69666398	1.41	Gm8172	predicted pseudogene 8172	60077	0.15
chr7_96211015_96211192	1.39	Tenm4	teneurin transmembrane protein 4	466	0.82
chr11_94160820_94161321	1.38	B230206L02Rik	RIKEN cDNA B230206L02 gene	25410	0.16
chr18_53294048_53294202	1.37	Snx24	sorting nexing 24	48356	0.15
chr8_68361979_68362165	1.36	1700125H03Rik	RIKEN cDNA 1700125H03 gene	6362	0.22
chr3_38246500_38246797	1.35	Gm2965	predicted gene 2965	23197	0.18
chr5_111837054_111837274	1.35	Gm36535	predicted gene, 36535	43777	0.15
chr14_27332479_27332650	1.32	Arhgef3	Rho guanine nucleotide exchange factor (GEF) 3	3502	0.27
chr10_44785500_44785699	1.31	4930431F10Rik	RIKEN cDNA 4930431F10 gene	46699	0.09
chr4_137476332_137476648	1.31	Hspg2	perlecan (heparan sulfate proteoglycan 2)	7687	0.14
chr12_92152419_92152618	1.29	Gm40598	predicted gene, 40598	8921	0.26
chr10_61080137_61080290	1.29	Pcbd1	pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1	9118	0.13
chr14_7818766_7819099	1.29	Flnb	filamin, beta	975	0.49
chr8_95703143_95704225	1.27	Ndrg4	N-myc downstream regulated gene 4	614	0.57
chr10_39266683_39266865	1.24	Gm31562	predicted gene, 31562	21728	0.17
chr2_106194434_106194642	1.23	Dcdc5	doublecortin domain containing 5	27519	0.21
chr13_34156890_34157101	1.20	Psmg4	proteasome (prosome, macropain) assembly chaperone 4	5969	0.13
chr4_108779892_108781170	1.20	Zfyve9	zinc finger, FYVE domain containing 9	28	0.97
chr5_38813852_38814038	1.20	Clnk	cytokine-dependent hematopoietic cell linker	62867	0.12
chr2_165043149_165043683	1.18	Ncoa5	nuclear receptor coactivator 5	8549	0.14
chr1_52454422_52454927	1.18	Gm23460	predicted gene, 23460	10130	0.16
chr5_123498102_123498542	1.17	Il31	interleukin 31	8833	0.07
chr4_91376156_91376714	1.15	Elavl2	ELAV like RNA binding protein 1	1	0.98
chr5_35280918_35281069	1.15	Adra2c	adrenergic receptor, alpha 2c	2674	0.31
chr14_22679666_22680655	1.14	Lrmda	leucine rich melanocyte differentiation associated	83647	0.09
chr2_152093402_152093892	1.13	Srxn1	sulfiredoxin 1 homolog (S. cerevisiae)	11869	0.13
chr12_15800918_15801338	1.12	Mir6387	microRNA 6387	27	0.97
chr7_49430942_49431093	1.12	Nav2	neuron navigator 2	19743	0.21
chr16_94467495_94467646	1.08	Ttc3	tetratricopeptide repeat domain 3	1048	0.48
chr9_21037477_21037931	1.07	Gm26592	predicted gene, 26592	78	0.91
chr9_46599951_46600255	1.07	Gm48945	predicted gene, 48945	7152	0.17
chr4_130519822_130520506	1.06	Nkain1	Na+/K+ transporting ATPase interacting 1	37824	0.17
chr6_22834709_22835019	1.05	Gm43629	predicted gene 43629	29535	0.14
chr10_117042279_117042645	1.04	Gm10747	predicted gene 10747	1284	0.32
chr8_126667748_126668147	1.04	Irf2bp2	interferon regulatory factor 2 binding protein 2	73961	0.1
chr1_8863954_8864105	1.04	Gm7445	predicted gene 7445	7266	0.17
chr10_7323409_7323560	1.02	Gm21321	predicted gene, 21321	67299	0.11
chr6_39787853_39788004	1.01	Mrps33	mitochondrial ribosomal protein S33	18114	0.16
chr1_186555717_186555886	1.00	A730004F24Rik	RIKEN cDNA A730004F24 gene	2671	0.35
chr9_91378183_91378872	1.00	Zic4	zinc finger protein of the cerebellum 4	115	0.94
chr19_5770648_5771783	0.99	Scyl1	SCY1-like 1 (S. cerevisiae)	38	0.93
chr5_149523996_149524147	0.99	Wdr95	WD40 repeat domain 95	4608	0.16
chr3_93445265_93445429	0.99	Tchh	trichohyalin	3017	0.12
chr15_102257553_102258012	0.98	Rarg	retinoic acid receptor, gamma	265	0.82
chr19_25598711_25598994	0.98	Dmrt3	doublesex and mab-3 related transcription factor 3	11449	0.22
chr1_42851025_42851764	0.98	Mrps9	mitochondrial ribosomal protein S9	109	0.97
chr11_101732407_101733143	0.97	Dhx8	DEAH (Asp-Glu-Ala-His) box polypeptide 8	144	0.94
chr17_15247926_15248133	0.97	Gm5091	predicted gene 5091	112	0.97
chr2_115895484_115896072	0.96	Meis2	Meis homeobox 2	22816	0.26
chr6_84143462_84143613	0.94	Dysf	dysferlin	3210	0.27
chr3_102734319_102735029	0.94	Tspan2	tetraspanin 2	145	0.87
chr5_124211305_124211583	0.93	Pitpnm2	phosphatidylinositol transfer protein, membrane-associated 2	4974	0.13
chr4_148384621_148385111	0.91	Gm13200	predicted gene 13200	25406	0.13
chr7_64156624_64156775	0.90	Trpm1	transient receptor potential cation channel, subfamily M, member 1	2771	0.23
chr5_25760091_25760623	0.90	Actr3b	ARP3 actin-related protein 3B	318	0.89
chr2_91956953_91957140	0.88	Dgkz	diacylglycerol kinase zeta	6611	0.12
chr10_4179226_4179383	0.88	Gm25369	predicted gene, 25369	9417	0.21
chr6_30079051_30079222	0.87	Nrf1	nuclear respiratory factor 1	2815	0.25
chr1_87184907_87185090	0.86	Prss56	protease, serine 56	1685	0.21
chr15_68230867_68231032	0.86	Zfat	zinc finger and AT hook domain containing	27838	0.18
chr5_81021312_81021925	0.86	Adgrl3	adhesion G protein-coupled receptor L3	25	0.99
chr3_88538384_88539050	0.86	Mir1905	microRNA 1905	2335	0.12
chr3_4798553_4798746	0.86	1110015O18Rik	RIKEN cDNA 1110015O18 gene	59	0.98
chr4_58184913_58185294	0.85	Svep1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	21493	0.25
chr13_52283378_52283752	0.85	Gm48199	predicted gene, 48199	103154	0.07
chr17_26658958_26659109	0.84	Atp6v0e	ATPase, H+ transporting, lysosomal V0 subunit E	4198	0.16
chr14_54572707_54573548	0.83	Ajuba	ajuba LIM protein	1045	0.3
chr13_56703202_56704180	0.81	Smad5	SMAD family member 5	23	0.98
chr5_35448262_35448469	0.81	Gm43377	predicted gene 43377	52267	0.09
chr13_117220464_117220939	0.81	Emb	embigin	15	0.86
chr12_113138507_113138658	0.80	Crip2	cysteine rich protein 2	1654	0.22
chr9_23120943_23121094	0.80	Bmper	BMP-binding endothelial regulator	102058	0.08
chr15_85724908_85725104	0.80	Ppara	peroxisome proliferator activated receptor alpha	9977	0.13
chr7_128687903_128688560	0.80	Inpp5f	inositol polyphosphate-5-phosphatase F	258	0.51
chr7_18858684_18858835	0.79	Pglyrp1	peptidoglycan recognition protein 1	12572	0.09
chr9_30149631_30149782	0.78	Gm47677	predicted gene, 47677	17869	0.26
chr4_63291492_63291785	0.77	Col27a1	collagen, type XXVII, alpha 1	8125	0.16
chr4_82344790_82345141	0.77	n-R5s188	nuclear encoded rRNA 5S 188	94445	0.08
chr2_70126801_70127190	0.77	Myo3b	myosin IIIB	30697	0.2
chr15_27503321_27503541	0.77	B230362B09Rik	RIKEN cDNA B230362B09 gene	481	0.78
chr12_73045160_73045311	0.77	Six1	sine oculis-related homeobox 1	56	0.98
chr12_91066386_91066537	0.76	Cep128	centrosomal protein 128	3050	0.24
chr7_99304833_99305309	0.76	Gm45591	predicted gene 45591	16129	0.12
chr9_27568724_27568875	0.76	Gm18585	predicted gene, 18585	14593	0.18
chr10_41594987_41595356	0.75	Ccdc162	coiled-coil domain containing 162	7418	0.15
chr6_119674280_119674487	0.74	Erc1	ELKS/RAB6-interacting/CAST family member 1	52278	0.15
chr6_30698043_30698194	0.74	Cep41	centrosomal protein 41	4369	0.14
chr1_128758816_128759186	0.73	Gm29599	predicted gene 29599	8075	0.23
chr8_12430018_12430574	0.73	Gm25239	predicted gene, 25239	33893	0.1
chr7_79578006_79578675	0.73	Gm45168	predicted gene 45168	728	0.49
chr13_115002286_115002437	0.73	Gm47776	predicted gene, 47776	67293	0.09
chr4_126262506_126262833	0.73	Trappc3	trafficking protein particle complex 3	269	0.86
chr2_160766567_160766718	0.72	Plcg1	phospholipase C, gamma 1	6524	0.18
chr8_25976584_25977311	0.72	Hgsnat	heparan-alpha-glucosaminide N-acetyltransferase	194	0.91
chr12_27151151_27151367	0.72	Gm9866	predicted gene 9866	9052	0.3
chr11_70200228_70200379	0.71	Slc16a11	solute carrier family 16 (monocarboxylic acid transporters), member 11	12449	0.07
chr7_125764515_125764737	0.71	D430042O09Rik	RIKEN cDNA D430042O09 gene	21629	0.21
chr7_16203170_16203481	0.71	Dhx34	DEAH (Asp-Glu-Ala-His) box polypeptide 34	876	0.44
chr14_99944188_99944685	0.70	Klf12	Kruppel-like factor 12	728	0.78
chr13_51155566_51155768	0.70	Nxnl2	nucleoredoxin-like 2	15355	0.16
chr16_7447825_7447988	0.70	Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	94936	0.1
chr4_45422743_45422894	0.70	Slc25a51	solute carrier family 25, member 51	14052	0.15
chr3_120982360_120982511	0.68	Gm43444	predicted gene 43444	38341	0.16
chr16_4643666_4644188	0.68	Coro7	coronin 7	2789	0.15
chr16_21370010_21370180	0.68	Magef1	melanoma antigen family F, 1	36739	0.15
chr11_87005447_87005718	0.68	Gm22387	predicted gene, 22387	8319	0.15
chr7_118991798_118991949	0.68	Gprc5b	G protein-coupled receptor, family C, group 5, member B	3338	0.25
chr2_39252305_39252456	0.66	Gm13504	predicted gene 13504	14939	0.13
chr7_16131212_16131667	0.66	Slc8a2	solute carrier family 8 (sodium/calcium exchanger), member 2	1091	0.37
chr2_157487979_157488189	0.66	Src	Rous sarcoma oncogene	30999	0.11
chr19_48333070_48333382	0.65	Gm23857	predicted gene, 23857	92581	0.08
chr10_108364964_108365547	0.65	Gm23105	predicted gene, 23105	1590	0.4
chr10_91881912_91882107	0.65	Gm31592	predicted gene, 31592	6820	0.31
chr15_99528118_99528269	0.64	Faim2	Fas apoptotic inhibitory molecule 2	28	0.96
chr18_60710262_60710458	0.64	Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	3029	0.23
chr5_38560766_38562198	0.64	Wdr1	WD repeat domain 1	61	0.97
chr17_79231357_79231508	0.64	Gm5230	predicted gene 5230	26617	0.21
chr11_50377311_50377861	0.62	Hnrnph1	heterogeneous nuclear ribonucleoprotein H1	133	0.94
chr9_21130693_21131801	0.62	Tyk2	tyrosine kinase 2	4	0.95
chr5_24685391_24686443	0.61	Nub1	negative regulator of ubiquitin-like proteins 1	70	0.96
chr1_32172857_32173290	0.61	Khdrbs2	KH domain containing, RNA binding, signal transduction associated 2	186	0.97
chr1_172221317_172221900	0.61	Casq1	calsequestrin 1	1740	0.2
chr1_193989994_193990577	0.61	Gm21362	predicted gene, 21362	123276	0.06
chr1_119421277_119422204	0.60	Inhbb	inhibin beta-B	508	0.79
chr13_52223178_52223329	0.60	Gm48199	predicted gene, 48199	42842	0.19
chr3_105052490_105052858	0.59	Cttnbp2nl	CTTNBP2 N-terminal like	251	0.92
chr11_98959522_98960759	0.59	Rara	retinoic acid receptor, alpha	272	0.84
chr12_105336106_105336602	0.59	Tunar	Tcl1 upstream neural differentiation associated RNA	240	0.93
chr3_106684799_106685270	0.59	Lrif1	ligand dependent nuclear receptor interacting factor 1	36	0.98
chr9_37090365_37090550	0.58	Pknox2	Pbx/knotted 1 homeobox 2	7148	0.16
chr7_140063115_140063403	0.58	Msx3	msh homeobox 3	14170	0.08
chr5_90223854_90224505	0.58	Cox18	cytochrome c oxidase assembly protein 18	178	0.96
chr14_64125810_64126264	0.57	9630015K15Rik	RIKEN cDNA 9630015K15 gene	9723	0.13
chr1_13189266_13189438	0.57	Gm38376	predicted gene, 38376	9638	0.16
chr2_155299641_155299792	0.56	Pigu	phosphatidylinositol glycan anchor biosynthesis, class U	1586	0.33
chr1_164454802_164455037	0.56	Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide	1142	0.41
chr17_83187838_83188005	0.56	Pkdcc	protein kinase domain containing, cytoplasmic	27371	0.19
chr10_83722468_83723424	0.56	1500009L16Rik	RIKEN cDNA 1500009L16 gene	20	0.98
chr1_78167977_78168321	0.56	Pax3	paired box 3	28689	0.2
chr8_88939205_88939356	0.55	Gm45504	predicted gene 45504	76206	0.09
chr1_134026827_134026978	0.55	Gm18970	predicted gene, 18970	6476	0.15
chr9_20830924_20831267	0.55	AC170598.1	complement component 3 precursor (C3P1) pseudogene	8433	0.1
chr12_58214120_58214334	0.54	Sstr1	somatostatin receptor 1	2423	0.4
chr18_69384579_69384730	0.54	Tcf4	transcription factor 4	31243	0.22
chr10_62651133_62651769	0.54	Ddx50	DEAD (Asp-Glu-Ala-Asp) box polypeptide 50	233	0.88
chr1_190979223_190979743	0.54	Vash2	vasohibin 2	187	0.9
chr12_78077415_78077566	0.54	Gm24994	predicted gene, 24994	88056	0.08
chr1_170110460_170110694	0.53	Ddr2	discoidin domain receptor family, member 2	16	0.98
chr5_46201957_46202226	0.52	Gm7931	predicted pseudogene 7931	212253	0.02

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb49

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	2.5	GO:0030091	protein repair(GO:0030091)
0.5	2.4	GO:0003433	chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.4	1.1	GO:0032289	central nervous system myelin formation(GO:0032289)
0.3	0.8	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.2	0.9	GO:0002913	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.2	0.8	GO:0001880	Mullerian duct regression(GO:0001880)
0.2	0.8	GO:0060023	soft palate development(GO:0060023)
0.2	0.6	GO:0021564	vagus nerve development(GO:0021564)
0.2	0.5	GO:0035022	positive regulation of Rac protein signal transduction(GO:0035022)
0.1	0.4	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1	0.5	GO:0060591	chondroblast differentiation(GO:0060591)
0.1	0.5	GO:0046881	positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.1	0.6	GO:0051204	protein insertion into mitochondrial membrane(GO:0051204)
0.1	0.3	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.1	3.1	GO:0090218	positive regulation of lipid kinase activity(GO:0090218)
0.1	0.6	GO:0090091	positive regulation of extracellular matrix disassembly(GO:0090091)
0.1	0.8	GO:2001135	regulation of endocytic recycling(GO:2001135)
0.1	0.4	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.1	0.5	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751)
0.1	0.3	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.1	0.5	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.1	0.5	GO:0003105	negative regulation of glomerular filtration(GO:0003105)
0.1	0.4	GO:0071883	receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1	0.3	GO:1990034	calcium ion export from cell(GO:1990034)
0.1	0.3	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.1	0.3	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
0.1	0.2	GO:0006001	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.1	0.4	GO:0030259	lipid glycosylation(GO:0030259)
0.1	0.2	GO:1901874	regulation of post-translational protein modification(GO:1901873) negative regulation of post-translational protein modification(GO:1901874)
0.1	0.4	GO:1902866	regulation of retina development in camera-type eye(GO:1902866)
0.1	1.4	GO:0042744	hydrogen peroxide catabolic process(GO:0042744)
0.1	0.4	GO:1902373	negative regulation of mRNA catabolic process(GO:1902373)
0.1	0.6	GO:0031000	response to caffeine(GO:0031000)
0.1	0.3	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.1	0.9	GO:0007183	SMAD protein complex assembly(GO:0007183)
0.1	0.9	GO:0031987	locomotion involved in locomotory behavior(GO:0031987)
0.1	0.2	GO:0045200	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1	0.6	GO:0090520	sphingolipid mediated signaling pathway(GO:0090520)
0.1	0.8	GO:0015727	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1	3.1	GO:0046513	ceramide biosynthetic process(GO:0046513)
0.1	0.4	GO:0099515	actin filament-based transport(GO:0099515)
0.1	0.2	GO:0097384	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.1	0.5	GO:0030836	positive regulation of actin filament depolymerization(GO:0030836)
0.1	0.6	GO:0009404	toxin metabolic process(GO:0009404)
0.1	0.5	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1	0.2	GO:0001927	exocyst assembly(GO:0001927)
0.1	0.1	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.1	0.6	GO:0003334	keratinocyte development(GO:0003334)
0.1	0.3	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	1.0	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.0	0.5	GO:0035563	positive regulation of chromatin binding(GO:0035563)
0.0	0.2	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.3	GO:0015074	DNA integration(GO:0015074)
0.0	0.6	GO:0021702	cerebellar Purkinje cell differentiation(GO:0021702)
0.0	0.1	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.2	GO:1904587	glycoprotein ERAD pathway(GO:0097466) response to glycoprotein(GO:1904587)
0.0	0.2	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.1	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.0	0.2	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0036135	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0	0.1	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0	0.4	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.7	GO:0014002	astrocyte development(GO:0014002)
0.0	0.2	GO:1905206	positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0	0.1	GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.0	0.8	GO:0048266	behavioral response to pain(GO:0048266)
0.0	0.2	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	1.0	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0	1.2	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0	0.2	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.3	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.1	GO:0072194	kidney smooth muscle tissue development(GO:0072194)
0.0	0.1	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.1	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.3	GO:0021521	ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0	0.4	GO:0047497	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0	0.1	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.0	0.0	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.0	GO:0090153	regulation of sphingolipid biosynthetic process(GO:0090153) regulation of membrane lipid metabolic process(GO:1905038)
0.0	0.0	GO:0021590	cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
0.0	0.2	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.0	GO:0050883	musculoskeletal movement, spinal reflex action(GO:0050883)
0.0	0.2	GO:0048505	regulation of timing of cell differentiation(GO:0048505)
0.0	0.1	GO:0097374	sensory neuron axon guidance(GO:0097374)
0.0	0.1	GO:1904017	response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0	0.1	GO:1902512	positive regulation of apoptotic DNA fragmentation(GO:1902512) positive regulation of DNA catabolic process(GO:1903626)
0.0	0.2	GO:0006273	lagging strand elongation(GO:0006273)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.2	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0	0.4	GO:0080111	DNA demethylation(GO:0080111)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.7	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.2	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.3	GO:0060396	growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0	0.2	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.2	GO:0097062	dendritic spine maintenance(GO:0097062)
0.0	0.2	GO:0051127	positive regulation of actin nucleation(GO:0051127)
0.0	0.1	GO:2000491	positive regulation of hepatic stellate cell activation(GO:2000491)
0.0	0.1	GO:0072015	glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0	0.1	GO:0061055	myotome development(GO:0061055)
0.0	0.1	GO:0002681	somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0	0.1	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.1	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0	0.1	GO:0060331	negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.0	0.1	GO:0030327	prenylated protein catabolic process(GO:0030327)
0.0	0.2	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.2	GO:0001553	luteinization(GO:0001553)
0.0	0.2	GO:1904871	protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.0	2.0	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0	0.1	GO:0009233	menaquinone metabolic process(GO:0009233)
0.0	0.2	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.1	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.2	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.5	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.0	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.2	GO:0048630	skeletal muscle tissue growth(GO:0048630)
0.0	0.1	GO:0030311	poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0	0.0	GO:0018171	peptidyl-cysteine oxidation(GO:0018171) regulation of ubiquitin-specific protease activity(GO:2000152)
0.0	0.2	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.2	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	0.1	GO:2001270	regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270)
0.0	0.1	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0	0.1	GO:1901097	negative regulation of autophagosome maturation(GO:1901097)
0.0	0.1	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0	0.1	GO:0046836	glycolipid transport(GO:0046836)
0.0	0.1	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.1	GO:0033623	regulation of integrin activation(GO:0033623)
0.0	0.2	GO:0097094	craniofacial suture morphogenesis(GO:0097094)
0.0	0.1	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.0	0.0	GO:0046146	tetrahydrobiopterin metabolic process(GO:0046146)
0.0	0.1	GO:0032827	natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.0	0.7	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0	0.1	GO:0016103	diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0	0.2	GO:0046337	phosphatidylethanolamine metabolic process(GO:0046337)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406)
0.0	0.0	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0	0.1	GO:0098908	regulation of neuronal action potential(GO:0098908)
0.0	0.1	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.0	GO:1990123	L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
0.0	0.0	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.1	GO:0042760	very long-chain fatty acid catabolic process(GO:0042760)
0.0	0.1	GO:0010694	positive regulation of alkaline phosphatase activity(GO:0010694)
0.0	0.0	GO:0042699	follicle-stimulating hormone signaling pathway(GO:0042699)
0.0	0.1	GO:0060510	Type II pneumocyte differentiation(GO:0060510)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0016560	protein import into peroxisome matrix, docking(GO:0016560)
0.0	0.0	GO:0008582	regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.0	0.1	GO:0044351	macropinocytosis(GO:0044351)
0.0	0.0	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.1	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0	0.0	GO:0021626	hindbrain maturation(GO:0021578) pons maturation(GO:0021586) central nervous system maturation(GO:0021626)
0.0	0.0	GO:0030952	establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0	0.0	GO:0001827	inner cell mass cell fate commitment(GO:0001827)
0.0	0.0	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402) regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.1	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.0	GO:0071608	macrophage inflammatory protein-1 alpha production(GO:0071608)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.1	GO:0070571	negative regulation of neuron projection regeneration(GO:0070571)
0.0	0.2	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
0.0	0.0	GO:2001171	positive regulation of ATP biosynthetic process(GO:2001171)
0.0	0.1	GO:0097034	mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0	0.1	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0	0.0	GO:0002540	leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.0	GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0	0.2	GO:0042572	retinol metabolic process(GO:0042572)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.0	GO:0072309	mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis(GO:0072309)
0.0	0.2	GO:0036342	post-anal tail morphogenesis(GO:0036342)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.4	GO:0030032	lamellipodium assembly(GO:0030032)
0.0	0.2	GO:0051602	response to electrical stimulus(GO:0051602)
0.0	0.1	GO:0045176	apical protein localization(GO:0045176)
0.0	0.0	GO:0042723	thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.0	0.0	GO:0051121	hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0	0.0	GO:0021694	cerebellar Purkinje cell layer formation(GO:0021694)
0.0	0.0	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.0	GO:0070842	aggresome assembly(GO:0070842)
0.0	0.3	GO:0048305	immunoglobulin secretion(GO:0048305)
0.0	0.1	GO:0051775	response to redox state(GO:0051775)
0.0	0.0	GO:1902953	positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
0.0	0.2	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.0	GO:1900222	negative regulation of beta-amyloid clearance(GO:1900222)
0.0	0.0	GO:2001180	negative regulation of interleukin-10 secretion(GO:2001180)
0.0	0.0	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.0	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.0	GO:0060283	negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.0	0.0	GO:0035993	deltoid tuberosity development(GO:0035993)
0.0	0.0	GO:0072205	metanephric collecting duct development(GO:0072205)
0.0	0.0	GO:0023021	termination of signal transduction(GO:0023021)
0.0	0.0	GO:2000321	positive regulation of T-helper 17 cell differentiation(GO:2000321)
0.0	0.0	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0	0.0	GO:0061091	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.0	0.0	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.0	GO:0070340	detection of bacterial lipopeptide(GO:0070340)
0.0	0.0	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.0	0.0	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.0	0.1	GO:0043312	neutrophil degranulation(GO:0043312)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	3.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2	0.5	GO:0043511	inhibin complex(GO:0043511)
0.1	0.4	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.1	0.4	GO:0071203	WASH complex(GO:0071203)
0.1	0.6	GO:0030008	TRAPP complex(GO:0030008)
0.1	0.4	GO:0031258	lamellipodium membrane(GO:0031258)
0.1	0.8	GO:0030126	COPI vesicle coat(GO:0030126)
0.1	0.2	GO:0035838	growing cell tip(GO:0035838)
0.1	0.3	GO:0070695	FHF complex(GO:0070695)
0.1	0.7	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.1	0.6	GO:0035253	ciliary rootlet(GO:0035253)
0.1	0.2	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.1	0.6	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.4	GO:0031209	SCAR complex(GO:0031209)
0.0	0.3	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.5	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	0.5	GO:0032797	SMN complex(GO:0032797)
0.0	0.1	GO:0005608	laminin-3 complex(GO:0005608)
0.0	0.1	GO:0072534	perineuronal net(GO:0072534)
0.0	0.1	GO:0005785	signal recognition particle receptor complex(GO:0005785)
0.0	0.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.1	GO:0090498	extrinsic component of Golgi membrane(GO:0090498)
0.0	0.3	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	0.9	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.2	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.5	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.5	GO:0031430	M band(GO:0031430)
0.0	1.4	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0	0.1	GO:0000974	Prp19 complex(GO:0000974)
0.0	0.5	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.0	0.5	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.4	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	1.1	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	0.4	GO:0030665	clathrin-coated vesicle membrane(GO:0030665)
0.0	0.5	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.1	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.0	0.1	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.0	0.2	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	1.3	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	0.1	GO:0048476	Holliday junction resolvase complex(GO:0048476)
0.0	1.5	GO:0030018	Z disc(GO:0030018)
0.0	0.3	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.0	0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.2	GO:0032433	filopodium tip(GO:0032433)
0.0	0.1	GO:0033263	CORVET complex(GO:0033263)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0034518	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.1	GO:0030314	junctional membrane complex(GO:0030314)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	1.1	GO:0005884	actin filament(GO:0005884)
0.0	0.3	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.0	GO:0008275	gamma-tubulin small complex(GO:0008275)
0.0	1.4	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.0	0.4	GO:0031901	early endosome membrane(GO:0031901)
0.0	0.0	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.1	GO:0031298	replication fork protection complex(GO:0031298)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.0	GO:0000322	storage vacuole(GO:0000322)
0.0	0.0	GO:0097427	microtubule bundle(GO:0097427)
0.0	0.7	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	0.1	GO:0035032	phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0	0.0	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.0	0.1	GO:0031674	I band(GO:0031674)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.0	GO:0071014	post-mRNA release spliceosomal complex(GO:0071014)
0.0	1.1	GO:0043197	dendritic spine(GO:0043197)
0.0	0.1	GO:0097470	ribbon synapse(GO:0097470)
0.0	0.1	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	0.0	GO:0044354	pinosome(GO:0044352) macropinosome(GO:0044354)
0.0	0.1	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.4	GO:0030173	integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	3.3	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.4	2.5	GO:0070191	methionine-R-sulfoxide reductase activity(GO:0070191)
0.2	0.6	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.2	1.5	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.2	0.6	GO:0016842	amidine-lyase activity(GO:0016842)
0.2	0.9	GO:0005131	growth hormone receptor binding(GO:0005131)
0.2	0.5	GO:0000702	oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.2	3.1	GO:0003746	translation elongation factor activity(GO:0003746)
0.2	0.5	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.1	1.3	GO:0016215	acyl-CoA desaturase activity(GO:0016215)
0.1	0.6	GO:0038064	collagen receptor activity(GO:0038064)
0.1	0.4	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.1	0.4	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.1	0.6	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.1	0.4	GO:0052833	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.1	0.2	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797)
0.1	0.6	GO:0035174	histone serine kinase activity(GO:0035174)
0.1	1.1	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.1	0.2	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1	0.5	GO:0034711	inhibin binding(GO:0034711)
0.1	0.2	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.1	0.2	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.1	0.5	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1	0.2	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1	0.2	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.1	0.2	GO:0034511	U3 snoRNA binding(GO:0034511)
0.1	0.3	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.1	1.0	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.3	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.8	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.4	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.2	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.2	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.0	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.5	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.6	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	1.3	GO:0004601	peroxidase activity(GO:0004601)
0.0	0.1	GO:1990460	leptin receptor binding(GO:1990460)
0.0	0.2	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.8	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.0	0.2	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.3	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	1.5	GO:0005518	collagen binding(GO:0005518)
0.0	0.7	GO:0042974	retinoic acid receptor binding(GO:0042974)
0.0	0.2	GO:0034842	3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.0	1.0	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.1	GO:0017089	glycolipid transporter activity(GO:0017089)
0.0	0.1	GO:0005483	soluble NSF attachment protein activity(GO:0005483)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.4	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0	0.1	GO:0070137	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.3	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.9	GO:0019894	kinesin binding(GO:0019894)
0.0	0.1	GO:0004942	anaphylatoxin receptor activity(GO:0004942)
0.0	0.0	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.1	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.0	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.1	GO:0001025	RNA polymerase III transcription factor binding(GO:0001025)
0.0	0.6	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.0	0.1	GO:0046428	4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623)
0.0	0.1	GO:0017099	very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0	1.2	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0	2.8	GO:0003714	transcription corepressor activity(GO:0003714)
0.0	0.1	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0	0.6	GO:0017147	Wnt-protein binding(GO:0017147)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.4	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.2	GO:0017160	Ral GTPase binding(GO:0017160)
0.0	0.1	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.3	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.3	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0	0.1	GO:0001222	transcription corepressor binding(GO:0001222)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.2	GO:0000146	microfilament motor activity(GO:0000146)
0.0	0.2	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.0	GO:0045340	mercury ion binding(GO:0045340)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.2	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.0	0.4	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.2	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.4	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.0	GO:0097603	temperature-gated ion channel activity(GO:0097603)
0.0	0.3	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.1	GO:0031005	filamin binding(GO:0031005)
0.0	0.0	GO:0001602	pancreatic polypeptide receptor activity(GO:0001602)
0.0	0.0	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.0	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	0.0	GO:0031493	nucleosomal histone binding(GO:0031493)
0.0	0.1	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.0	GO:0032051	clathrin light chain binding(GO:0032051)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.3	GO:0043883	N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.2	GO:0004970	ionotropic glutamate receptor activity(GO:0004970)
0.0	0.0	GO:0032138	single base insertion or deletion binding(GO:0032138)
0.0	0.1	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity(GO:0008796)
0.0	0.0	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.1	0.8	PID ALK2 PATHWAY	ALK2 signaling events
0.1	1.5	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	1.4	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	1.4	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	0.8	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.5	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	0.5	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	0.7	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.0	0.2	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.5	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.1	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	0.1	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	0.0	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.0	0.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.1	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	0.1	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.0	0.2	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.3	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	0.4	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	0.2	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.0	0.3	PID IL2 1PATHWAY	IL2-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.1	2.0	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	0.8	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1	0.6	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.1	1.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.1	0.1	REACTOME MITOTIC G2 G2 M PHASES	Genes involved in Mitotic G2-G2/M phases
0.1	0.6	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1	0.5	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.6	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.4	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	1.0	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.9	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.7	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.0	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0	1.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.4	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0	0.0	REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX	Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.0	0.3	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.4	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.3	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.0	0.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.3	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	1.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.3	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.0	REACTOME OPSINS	Genes involved in Opsins
0.0	0.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.3	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	0.2	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	0.4	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0	0.4	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	0.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.7	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0	0.3	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.1	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.2	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.2	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.3	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.0	0.0	REACTOME SIGNALING BY FGFR	Genes involved in Signaling by FGFR
0.0	0.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.4	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK