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ENCODE: ATAC-seq of different tissues during embryonic development
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Zfp410

Z-value: 1.03

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Transcription factors associated with Zfp410

Gene Symbol Gene ID Gene Info
ENSMUSG00000042472.10 Zfp410

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
Zfp410chr12_84317435_843176373910.4945880.525.4e-05Click!
Zfp410chr12_84316711_84316909420.7681680.439.6e-04Click!
Zfp410chr12_84317218_843174121700.5784240.421.5e-03Click!
Zfp410chr12_84304058_84304308126690.1080460.376.0e-03Click!
Zfp410chr12_84327310_84327462540.9562680.181.8e-01Click!

Activity of the Zfp410 motif across conditions

Conditions sorted by the z-value of the Zfp410 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr6_125095392_125097556 47.37 Chd4
chromodomain helicase DNA binding protein 4
95
0.84
chr6_125088567_125089479 19.27 2010008C14Rik
RIKEN cDNA 2010008C14 gene
5586
0.08
chr6_125089773_125090131 10.40 Chd4
chromodomain helicase DNA binding protein 4
6029
0.07
chr10_60078002_60078293 10.07 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
28072
0.16
chr2_153495495_153495649 7.01 4930404H24Rik
RIKEN cDNA 4930404H24 gene
2782
0.24
chr15_44462509_44462660 6.95 Pkhd1l1
polycystic kidney and hepatic disease 1-like 1
5031
0.19
chr17_36030163_36030330 5.92 H2-T23
histocompatibility 2, T region locus 23
2295
0.1
chr6_144901597_144901788 5.65 Gm22792
predicted gene, 22792
98060
0.06
chr7_110088063_110088458 5.23 Zfp143
zinc finger protein 143
3369
0.16
chr4_123285054_123285219 4.78 Pabpc4
poly(A) binding protein, cytoplasmic 4
2041
0.17
chr16_22893442_22893593 4.63 Gm30505
predicted gene, 30505
869
0.37
chr5_103977347_103977558 4.51 Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
42
0.97
chr1_131526874_131527597 4.46 Srgap2
SLIT-ROBO Rho GTPase activating protein 2
112
0.89
chr11_102368389_102368661 4.42 Slc4a1
solute carrier family 4 (anion exchanger), member 1
2322
0.16
chr10_59347750_59347911 4.35 P4ha1
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
24462
0.16
chr16_21788047_21788243 4.01 Ehhadh
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
338
0.82
chr2_30658442_30659224 3.97 Gm14486
predicted gene 14486
11075
0.15
chr5_123142139_123142306 3.90 Setd1b
SET domain containing 1B
29
0.88
chr12_111437288_111437481 3.90 Tnfaip2
tumor necrosis factor, alpha-induced protein 2
5085
0.13
chr1_31094793_31095271 3.78 4931428L18Rik
RIKEN cDNA 4931428L18 gene
1422
0.36
chr10_56106920_56107369 3.64 Msl3l2
MSL3 like 2
227
0.94
chr12_85704751_85704902 3.62 Gm47285
predicted gene, 47285
13737
0.12
chr6_98589121_98589272 3.37 4930595L18Rik
RIKEN cDNA 4930595L18 gene
37089
0.21
chr15_79833949_79834578 3.30 Cbx6
chromobox 6
11
0.5
chr5_100500528_100500689 3.24 Lin54
lin-54 homolog (C. elegans)
16
0.85
chr11_119040519_119041332 3.16 Cbx8
chromobox 8
14
0.97
chr12_12488288_12488471 2.98 4921511I17Rik
RIKEN cDNA 4921511I17 gene
95764
0.08
chr8_110933315_110933782 2.95 St3gal2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
1627
0.24
chr7_103875101_103875284 2.93 Olfr66
olfactory receptor 66
7049
0.06
chr7_64040446_64040628 2.89 Gm45054
predicted gene 45054
289
0.89
chr6_90608041_90608201 2.76 Slc41a3
solute carrier family 41, member 3
3396
0.18
chr14_67941339_67941490 2.76 Dock5
dedicator of cytokinesis 5
7972
0.25
chr7_99590701_99590937 2.48 Arrb1
arrestin, beta 1
3774
0.14
chr18_4804091_4804297 2.43 Gm10556
predicted gene 10556
8292
0.26
chr6_32479585_32479786 2.06 Plxna4os2
plexin A4, opposite strand 2
28515
0.19
chr5_139803949_139804524 2.05 Tmem184a
transmembrane protein 184a
3744
0.14
chr17_71251382_71251788 2.04 Emilin2
elastin microfibril interfacer 2
3821
0.19
chr12_85785503_85785771 1.97 Flvcr2
feline leukemia virus subgroup C cellular receptor 2
10807
0.15
chr3_10316055_10316213 1.96 Impa1
inositol (myo)-1(or 4)-monophosphatase 1
518
0.62
chr2_130577744_130577954 1.75 Oxt
oxytocin
1676
0.2
chr11_86382617_86383101 1.73 Med13
mediator complex subunit 13
25257
0.16
chr15_102103920_102104453 1.64 Tns2
tensin 2
239
0.87
chr10_24911202_24911353 1.63 Mir6905
microRNA 6905
613
0.63
chr17_27796564_27796715 1.58 Rps2-ps9
ribosomal protein S2, pseudogene 9
12215
0.12
chr14_64949310_64950069 1.58 Hmbox1
homeobox containing 1
57
0.83
chr4_135873258_135873453 1.56 Pnrc2
proline-rich nuclear receptor coactivator 2
215
0.88
chr19_23687766_23687949 1.54 Ptar1
protein prenyltransferase alpha subunit repeat containing 1
113
0.95
chr13_73448622_73448799 1.54 Lpcat1
lysophosphatidylcholine acyltransferase 1
18487
0.2
chr15_86110952_86111103 1.53 Gm15722
predicted gene 15722
20967
0.16
chr7_12978404_12978717 1.52 Zfp446
zinc finger protein 446
322
0.74
chr13_81853046_81853197 1.42 Cetn3
centrin 3
61144
0.11
chr2_5549339_5549504 1.36 Gm13216
predicted gene 13216
54150
0.15
chr1_156222336_156222944 1.35 Gm38113
predicted gene, 38113
4653
0.18
chrX_150549242_150549398 1.34 Alas2
aminolevulinic acid synthase 2, erythroid
1861
0.24
chr9_88483752_88484150 1.30 Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
1377
0.28
chr14_52196866_52197101 1.25 Supt16
SPT16, facilitates chromatin remodeling subunit
433
0.47
chr13_3744124_3744306 1.25 Gm47695
predicted gene, 47695
15610
0.15
chr2_33788959_33789191 1.21 Mvb12b
multivesicular body subunit 12B
316
0.9
chr7_67229002_67229160 1.17 Lysmd4
LysM, putative peptidoglycan-binding, domain containing 4
5472
0.17
chr2_38504413_38504578 1.17 Gm44062
predicted gene, 44062
4303
0.14
chr11_3134327_3135400 1.12 Sfi1
Sfi1 homolog, spindle assembly associated (yeast)
1144
0.38
chr12_81002763_81003134 1.12 Smoc1
SPARC related modular calcium binding 1
23860
0.14
chr4_97025797_97025948 1.05 Gm27521
predicted gene, 27521
108852
0.07
chr10_40152341_40152498 1.03 Slc16a10
solute carrier family 16 (monocarboxylic acid transporters), member 10
10161
0.13
chr8_108613044_108613195 1.03 Zfhx3
zinc finger homeobox 3
781
0.71
chr9_57970489_57970640 1.01 Gm17322
predicted gene, 17322
27477
0.11
chr9_73044180_73044397 1.01 Rab27a
RAB27A, member RAS oncogene family
566
0.54
chr4_129671576_129671731 1.00 Kpna6
karyopherin (importin) alpha 6
875
0.4
chr1_36088323_36089060 0.99 Hs6st1
heparan sulfate 6-O-sulfotransferase 1
12999
0.13
chr5_136810958_136811326 0.92 Col26a1
collagen, type XXVI, alpha 1
27167
0.15
chr1_189619014_189619289 0.92 Gm38122
predicted gene, 38122
21083
0.19
chr19_53891604_53892011 0.91 Pdcd4
programmed cell death 4
424
0.79
chr19_56378923_56379247 0.91 Nrap
nebulin-related anchoring protein
780
0.61
chr18_20936839_20937401 0.90 Rnf125
ring finger protein 125
7505
0.22
chr2_33335990_33336141 0.90 Gm13537
predicted gene 13537
12894
0.16
chr10_80084809_80085161 0.86 Sbno2
strawberry notch 2
9546
0.09
chr5_129179631_129179797 0.84 Rps16-ps2
ribosomal protein S16, pseudogene 2
51197
0.14
chr2_30200927_30201078 0.83 Kyat1
kynurenine aminotransferase 1
2643
0.14
chr4_142166267_142166486 0.83 Kazn
kazrin, periplakin interacting protein
7322
0.19
chr3_84005748_84005921 0.82 Tmem131l
transmembrane 131 like
34294
0.18
chr4_115822744_115822895 0.81 Mob3c
MOB kinase activator 3C
5273
0.13
chr12_16544817_16544968 0.73 Lpin1
lipin 1
17146
0.24
chr15_40674821_40674977 0.70 Zfpm2
zinc finger protein, multitype 2
9909
0.29
chr17_12249866_12250017 0.70 Map3k4
mitogen-activated protein kinase kinase kinase 4
16045
0.14
chr3_19635280_19635455 0.66 1700064H15Rik
RIKEN cDNA 1700064H15 gene
6690
0.16
chr1_156987967_156988148 0.65 4930439D14Rik
RIKEN cDNA 4930439D14 gene
48219
0.1
chr10_8912784_8913075 0.59 Gm48727
predicted gene, 48727
8948
0.16
chr14_65718314_65718512 0.59 Scara5
scavenger receptor class A, member 5
41936
0.15
chr12_64968157_64968335 0.56 Togaram1
TOG array regulator of axonemal microtubules 1
2190
0.21
chr12_16731064_16731426 0.56 Greb1
gene regulated by estrogen in breast cancer protein
8883
0.17
chr9_70044819_70045125 0.54 Gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
6884
0.14
chr11_11928614_11928944 0.53 Grb10
growth factor receptor bound protein 10
9837
0.18
chrX_60014607_60014758 0.53 F9
coagulation factor IX
15218
0.19
chr7_19160187_19160727 0.52 Gipr
gastric inhibitory polypeptide receptor
4637
0.08
chr8_17053595_17053746 0.51 3110080E11Rik
RIKEN cDNA 3110080E11 gene
137488
0.05
chr5_125203053_125203442 0.49 Ncor2
nuclear receptor co-repressor 2
24028
0.18
chr1_92921240_92921447 0.46 Rnpepl1
arginyl aminopeptidase (aminopeptidase B)-like 1
1729
0.19
chr17_30006978_30007129 0.45 Zfand3
zinc finger, AN1-type domain 3
744
0.53
chr1_85578306_85578542 0.44 G530012D18Rik
RIKEN cDNA G530012D1 gene
2748
0.14
chr17_26497654_26497955 0.43 Gm34455
predicted gene, 34455
5396
0.12
chr7_104507532_104507683 0.38 Trim30d
tripartite motif-containing 30D
218
0.86
chr11_54250431_54250582 0.38 Csf2
colony stimulating factor 2 (granulocyte-macrophage)
839
0.48
chr18_74740901_74741052 0.37 Myo5b
myosin VB
7211
0.18
chr4_85740566_85740717 0.35 Adamtsl1
ADAMTS-like 1
226314
0.02
chr1_87397239_87397390 0.34 Kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
2585
0.2
chr3_117001572_117002191 0.32 Gm9332
predicted gene 9332
2295
0.25
chr4_133701094_133701537 0.32 Mir7227
microRNA 7227
15793
0.12
chr4_131829199_131829486 0.29 Ptpru
protein tyrosine phosphatase, receptor type, U
7826
0.15
chr16_34898145_34898335 0.27 Mylk
myosin, light polypeptide kinase
2015
0.36
chr4_106827730_106828478 0.22 Gm12746
predicted gene 12746
19816
0.15
chr1_40266407_40266915 0.22 Il1r1
interleukin 1 receptor, type I
4
0.98
chr2_146763416_146764171 0.22 Gm14111
predicted gene 14111
8088
0.27
chr2_166080996_166081365 0.21 Sulf2
sulfatase 2
3061
0.24
chr1_182053014_182053342 0.20 Gm37177
predicted gene, 37177
18225
0.14
chr17_3436818_3437224 0.20 Tiam2
T cell lymphoma invasion and metastasis 2
2752
0.28
chr7_128344992_128345271 0.19 Gm6916
predicted pseudogene 6916
4664
0.13
chr7_92817657_92817808 0.17 Rab30
RAB30, member RAS oncogene family
2173
0.27
chr3_89696244_89696704 0.16 Adar
adenosine deaminase, RNA-specific
18548
0.14
chr1_85116074_85116225 0.15 Gm16038
predicted gene 16038
830
0.42
chr11_70970609_70971178 0.14 Rpain
RPA interacting protein
364
0.67
chr2_6226731_6226967 0.13 Echdc3
enoyl Coenzyme A hydratase domain containing 3
13816
0.16
chr14_21741906_21742090 0.13 Gm15935
predicted gene 15935
409
0.5
chr8_126588694_126589418 0.12 Irf2bp2
interferon regulatory factor 2 binding protein 2
4930
0.25
chr8_10948388_10948539 0.12 Gm44955
predicted gene 44955
573
0.62
chr5_64576943_64577119 0.12 Gm42566
predicted gene 42566
12212
0.12
chr19_27228331_27228482 0.12 Vldlr
very low density lipoprotein receptor
10368
0.19
chr8_128491772_128491970 0.09 Nrp1
neuropilin 1
132474
0.04
chr5_15488572_15488741 0.09 Gm21149
predicted gene, 21149
12133
0.16
chr10_86286801_86286952 0.07 Timp3
tissue inhibitor of metalloproteinase 3
13496
0.22
chr8_26993871_26994644 0.05 Gm45370
predicted gene 45370
1993
0.18
chr1_165091659_165092046 0.05 4930568G15Rik
RIKEN cDNA 4930568G15 gene
76
0.97
chr1_133089589_133089740 0.04 Pik3c2b
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
21085
0.13
chr3_144932528_144932679 0.04 Clca4b
chloride channel accessory 4B
74
0.96
chr5_113804361_113804709 0.04 Tmem119
transmembrane protein 119
4019
0.12
chr8_106054637_106054799 0.03 Nfatc3
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
4122
0.12
chr5_25705272_25705934 0.03 Xrcc2
X-ray repair complementing defective repair in Chinese hamster cells 2
161
0.93
chr11_20460573_20460736 0.03 Gm12034
predicted gene 12034
14242
0.23
chr9_110333949_110334114 0.01 Scap
SREBF chaperone
395
0.75

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of Zfp410

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.4 41.9 GO:0072553 terminal button organization(GO:0072553)
0.4 4.0 GO:0051014 actin filament severing(GO:0051014)
0.2 0.7 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.2 0.7 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.2 3.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.2 1.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 0.6 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.2 1.3 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.2 0.5 GO:0045054 constitutive secretory pathway(GO:0045054)
0.1 2.1 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 0.4 GO:0018992 germ-line sex determination(GO:0018992)
0.1 0.6 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 1.3 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 0.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 3.1 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 1.2 GO:0006020 inositol metabolic process(GO:0006020)
0.1 1.5 GO:0018342 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.1 0.7 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 1.1 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.1 0.3 GO:0043133 hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.1 0.3 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.1 0.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.3 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 0.8 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 0.1 GO:0072364 regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter(GO:0072364)
0.1 1.2 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.1 0.2 GO:2000321 positive regulation of T-helper 17 cell differentiation(GO:2000321)
0.1 1.4 GO:0014850 response to muscle activity(GO:0014850)
0.1 0.9 GO:0051601 exocyst localization(GO:0051601)
0.1 0.4 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.7 GO:0014823 response to activity(GO:0014823)
0.1 0.2 GO:2000823 regulation of androgen receptor activity(GO:2000823)
0.1 1.7 GO:0048240 sperm capacitation(GO:0048240)
0.1 0.2 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 0.5 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.1 0.2 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1 0.2 GO:0006551 leucine metabolic process(GO:0006551)
0.1 4.5 GO:0046889 positive regulation of lipid biosynthetic process(GO:0046889)
0.1 0.2 GO:0002584 negative regulation of antigen processing and presentation of peptide antigen(GO:0002584)
0.1 0.3 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256)
0.1 3.2 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 0.1 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.1 0.2 GO:0032485 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.1 0.2 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.1 0.2 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.2 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.1 0.2 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 0.1 GO:0010963 regulation of L-arginine import(GO:0010963)
0.0 0.0 GO:0032079 positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.0 0.2 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.2 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.3 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0 0.3 GO:0010388 cullin deneddylation(GO:0010388)
0.0 1.4 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.4 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.0 0.1 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.0 0.1 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.7 GO:0055090 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.0 0.3 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.3 GO:0045820 negative regulation of glycolytic process(GO:0045820)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.6 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.1 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0021564 vagus nerve development(GO:0021564)
0.0 0.3 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.0 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.3 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.1 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.1 GO:0009128 purine nucleoside monophosphate catabolic process(GO:0009128)
0.0 0.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 0.1 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0 0.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.1 GO:0002725 negative regulation of T cell cytokine production(GO:0002725) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0 0.1 GO:0071684 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.5 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:2000409 positive regulation of T cell extravasation(GO:2000409)
0.0 0.2 GO:0016556 mRNA modification(GO:0016556)
0.0 0.1 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.1 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) serotonin biosynthetic process(GO:0042427) neurotransmitter loading into synaptic vesicle(GO:0098700) primary amino compound biosynthetic process(GO:1901162)
0.0 0.1 GO:0032439 endosome localization(GO:0032439)
0.0 0.9 GO:0006094 gluconeogenesis(GO:0006094)
0.0 0.1 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.2 GO:0045078 regulation of interferon-gamma biosynthetic process(GO:0045072) positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 1.2 GO:0048524 positive regulation of viral process(GO:0048524)
0.0 0.1 GO:1905206 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0 0.0 GO:0033087 negative regulation of immature T cell proliferation(GO:0033087)
0.0 0.0 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.0 0.0 GO:0032741 positive regulation of interleukin-18 production(GO:0032741)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.1 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.0 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.0 0.0 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.0 0.7 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.1 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.1 GO:0019054 modulation by virus of host process(GO:0019054)
0.0 0.0 GO:0030825 positive regulation of cGMP metabolic process(GO:0030825)
0.0 0.1 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.0 0.0 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.0 0.0 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.8 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.2 GO:2000505 regulation of energy homeostasis(GO:2000505)
0.0 0.0 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.0 0.0 GO:1903984 regulation of TRAIL-activated apoptotic signaling pathway(GO:1903121) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 0.2 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.0 0.0 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.0 0.1 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.0 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.1 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.0 0.2 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.8 GO:0048661 positive regulation of smooth muscle cell proliferation(GO:0048661)
0.0 0.1 GO:0070189 kynurenine metabolic process(GO:0070189)
0.0 0.0 GO:0070093 negative regulation of luteinizing hormone secretion(GO:0033685) negative regulation of glucagon secretion(GO:0070093)
0.0 3.5 GO:0032259 methylation(GO:0032259)
0.0 0.0 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0033160 positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0 0.0 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.0 0.0 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.1 GO:0010455 positive regulation of cell fate commitment(GO:0010455)
0.0 0.0 GO:0034447 glycoprotein transport(GO:0034436) very-low-density lipoprotein particle clearance(GO:0034447) reelin-mediated signaling pathway(GO:0038026)
0.0 0.0 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.0 0.1 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.1 GO:0060736 prostate gland growth(GO:0060736)
0.0 0.0 GO:1904528 regulation of microtubule binding(GO:1904526) positive regulation of microtubule binding(GO:1904528)
0.0 0.1 GO:0009048 dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.2 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 41.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.4 4.0 GO:0044327 dendritic spine head(GO:0044327)
0.3 1.1 GO:0097452 GAIT complex(GO:0097452)
0.3 3.0 GO:0035102 PRC1 complex(GO:0035102)
0.2 0.7 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.2 3.4 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.5 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 1.1 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.6 GO:0005927 muscle tendon junction(GO:0005927)
0.1 1.0 GO:0000124 SAGA complex(GO:0000124)
0.1 0.6 GO:0000796 condensin complex(GO:0000796)
0.1 4.6 GO:0005811 lipid particle(GO:0005811)
0.1 0.3 GO:1990246 uniplex complex(GO:1990246)
0.1 1.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 1.8 GO:0031519 PcG protein complex(GO:0031519)
0.1 0.4 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.9 GO:0000145 exocyst(GO:0000145)
0.1 0.1 GO:0032010 phagolysosome(GO:0032010)
0.0 0.3 GO:0070820 tertiary granule(GO:0070820)
0.0 0.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.5 GO:0032039 integrator complex(GO:0032039)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0001650 fibrillar center(GO:0001650)
0.0 1.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.3 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 2.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.1 GO:0072562 blood microparticle(GO:0072562)
0.0 0.1 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.0 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.1 GO:0060091 kinocilium(GO:0060091)
0.0 0.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0045179 apical cortex(GO:0045179)
0.0 0.0 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.0 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0000805 X chromosome(GO:0000805)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.0 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 1.7 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 0.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.0 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 41.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.8 3.3 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.5 4.4 GO:0034778 pinocarveol dehydrogenase activity(GO:0018446) chloral hydrate dehydrogenase activity(GO:0018447) hydroxymethylmethylsilanediol oxidase activity(GO:0018448) 1-phenylethanol dehydrogenase activity(GO:0018449) myrtenol dehydrogenase activity(GO:0018450) cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity(GO:0034522) 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity(GO:0034582) 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity(GO:0034778) cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity(GO:0034817) citronellol dehydrogenase activity(GO:0034821) naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity(GO:0034847) 2,4,4-trimethyl-1-pentanol dehydrogenase activity(GO:0034863) 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity(GO:0034868) 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity(GO:0034871) endosulfan diol dehydrogenase activity(GO:0034891) endosulfan hydroxyether dehydrogenase activity(GO:0034901) 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity(GO:0034918) 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity(GO:0034944) versicolorin reductase activity(GO:0042469) ketoreductase activity(GO:0045703)
0.3 3.0 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.3 1.2 GO:0008934 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.2 0.7 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 1.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.2 0.7 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.2 1.3 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.2 0.5 GO:0031893 vasopressin receptor binding(GO:0031893)
0.2 1.5 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.1 0.4 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 0.3 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 3.9 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 0.3 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.1 3.4 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 0.2 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.1 0.3 GO:0047105 aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.1 1.2 GO:0008143 poly(A) binding(GO:0008143)
0.1 0.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.4 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.1 0.2 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.1 1.4 GO:0052830 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.1 1.7 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.7 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0 0.1 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.1 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 1.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0001164 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 0.1 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 1.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.2 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.5 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.2 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.0 0.0 GO:0035851 Krueppel-associated box domain binding(GO:0035851)
0.0 0.1 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.1 GO:0005329 dopamine transmembrane transporter activity(GO:0005329)
0.0 0.3 GO:0016594 glycine binding(GO:0016594)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.0 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.7 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.1 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.2 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.3 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.3 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.0 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0 0.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 2.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.4 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.1 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.9 GO:0016429 tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.0 GO:0019002 GMP binding(GO:0019002)
0.0 0.0 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.0 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.0 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.2 GO:0008483 transaminase activity(GO:0008483)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.0 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 0.1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0 0.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 42.1 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 0.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID BMP PATHWAY BMP receptor signaling
0.0 0.7 PID AURORA B PATHWAY Aurora B signaling
0.0 1.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.1 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.5 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.4 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 0.9 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 0.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 0.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.2 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.0 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.1 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins