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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Ascl2

Z-value: 0.53

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Transcription factors associated with Ascl2

Gene Symbol	Gene ID	Gene Info
Ascl2 Ensembl NCBI MGI UniProt	ENSMUSG00000009248.5	Ascl2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Ascl2	chr7_142967530_142967799	1053	0.436286	-0.26	6.2e-01	Click!

Activity of the Ascl2 motif across conditions

Conditions sorted by the z-value of the Ascl2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_67263308_67263719	0.38	Mlf1	myeloid leukemia factor 1	110584	0.06
chr16_17208938_17209184	0.25	Rimbp3	RIMS binding protein 3	458	0.65
chr2_173158061_173158212	0.23	Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	5054	0.19
chr10_63410268_63410432	0.22	Gm7530	predicted gene 7530	2649	0.19
chr14_19751408_19751584	0.22	Nid2	nidogen 2	212	0.93
chr12_100199636_100199926	0.20	Calm1	calmodulin 1	252	0.89
chr9_65296934_65297096	0.19	Gm16218	predicted gene 16218	904	0.39
chr1_160692286_160692437	0.18	Gm37328	predicted gene, 37328	34320	0.09
chr15_31058451_31058629	0.17	4930430F21Rik	RIKEN cDNA 4930430F21 gene	19412	0.2
chr2_173159829_173160580	0.16	Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	7122	0.18
chr2_25262755_25263227	0.16	Tprn	taperin	373	0.59
chr11_102399997_102400189	0.15	Rundc3a	RUN domain containing 3A	235	0.85
chr1_184873376_184873577	0.15	C130074G19Rik	RIKEN cDNA C130074G19 gene	9742	0.16
chr8_94173317_94173477	0.15	Gm45774	predicted gene 45774	15	0.89
chr8_10937238_10937412	0.14	Gm45042	predicted gene 45042	7438	0.11
chr10_69208384_69208535	0.14	Rhobtb1	Rho-related BTB domain containing 1	93	0.97
chr2_31519156_31519420	0.14	Ass1	argininosuccinate synthetase 1	798	0.61
chr5_114561036_114561196	0.14	Fam222a	family with sequence similarity 222, member A	6900	0.17
chr5_124225128_124225319	0.14	Pitpnm2os1	phosphatidylinositol transfer protein, membrane-associated 2, opposite strand 1	4502	0.13
chr14_65740190_65740357	0.13	Scara5	scavenger receptor class A, member 5	63796	0.1
chr12_28910370_28910535	0.13	Gm31508	predicted gene, 31508	223	0.94
chr1_93137985_93138369	0.13	Agxt	alanine-glyoxylate aminotransferase	1702	0.26
chr11_120013435_120013644	0.13	Aatk	apoptosis-associated tyrosine kinase	1131	0.23
chr5_24976790_24976954	0.13	1500035N22Rik	RIKEN cDNA 1500035N22 gene	8970	0.18
chr19_46141233_46141384	0.13	Pitx3	paired-like homeodomain transcription factor 3	325	0.82
chr1_59157472_59157626	0.13	Mpp4	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	1112	0.34
chr7_114325255_114325465	0.12	Psma1	proteasome subunit alpha 1	49242	0.13
chr3_116329378_116329892	0.12	Gm29151	predicted gene 29151	20468	0.17
chr1_36149451_36149602	0.12	Uggt1	UDP-glucose glycoprotein glucosyltransferase 1	998	0.45
chr12_84187018_84187182	0.12	Gm19327	predicted gene, 19327	706	0.52
chr12_28800275_28800436	0.12	Gm48905	predicted gene, 48905	9783	0.16
chr19_3893794_3894051	0.12	Chka	choline kinase alpha	2191	0.13
chr9_47324524_47324675	0.12	Gm31816	predicted gene, 31816	38151	0.19
chr4_117040674_117041081	0.12	Eif2b3	eukaryotic translation initiation factor 2B, subunit 3	3599	0.12
chr3_108788010_108788161	0.12	Stxbp3	syntaxin binding protein 3	9699	0.15
chr19_32648548_32648744	0.12	Papss2	3'-phosphoadenosine 5'-phosphosulfate synthase 2	28641	0.18
chr2_25472167_25472318	0.12	Ptgds	prostaglandin D2 synthase (brain)	2196	0.12
chr4_82415983_82416134	0.11	n-R5s188	nuclear encoded rRNA 5S 188	23352	0.23
chr19_45749067_45749428	0.11	Gm15491	predicted gene 15491	261	0.52
chr10_75783826_75784124	0.11	Gstt3	glutathione S-transferase, theta 3	2561	0.13
chr13_74209069_74209298	0.11	Exoc3	exocyst complex component 3	451	0.81
chr19_46628011_46628401	0.11	Wbp1l	WW domain binding protein 1 like	4805	0.15
chrX_63961215_63961366	0.11	Gm8260	predicted gene 8260	86616	0.1
chr7_30051105_30051256	0.11	Zfp14	zinc finger protein 14	193	0.88
chr13_93628549_93628834	0.11	Gm15622	predicted gene 15622	3309	0.2
chr17_31306868_31307019	0.11	Slc37a1	solute carrier family 37 (glycerol-3-phosphate transporter), member 1	522	0.71
chr17_56108904_56109250	0.11	Plin4	perilipin 4	725	0.45
chr2_27212850_27213071	0.11	Sardh	sarcosine dehydrogenase	2672	0.2
chrX_169904110_169904261	0.11	Mid1	midline 1	22766	0.2
chr11_35458160_35458335	0.11	Slit3	slit guidance ligand 3	86438	0.09
chr6_149138694_149138910	0.11	Etfbkmt	electron transfer flavoprotein beta subunit lysine methyltransferase	1047	0.41
chr14_12103232_12103447	0.11	Ptprg	protein tyrosine phosphatase, receptor type, G	12179	0.23
chr17_49440803_49440954	0.11	Mocs1	molybdenum cofactor synthesis 1	7682	0.22
chr12_112597485_112597658	0.11	Inf2	inverted formin, FH2 and WH2 domain containing	7086	0.14
chr4_141663419_141663714	0.11	Plekhm2	pleckstrin homology domain containing, family M (with RUN domain) member 2	552	0.67
chr6_72120521_72121047	0.11	4933431G14Rik	RIKEN cDNA 4933431G14 gene	2156	0.2
chr10_24915615_24916009	0.10	Arg1	arginase, liver	595	0.65
chr7_112276934_112277125	0.10	Mical2	microtubule associated monooxygenase, calponin and LIM domain containing 2	5730	0.31
chr5_122060223_122060392	0.10	Cux2	cut-like homeobox 2	10205	0.14
chr8_104909005_104909158	0.10	Gm8798	predicted gene 8798	16335	0.09
chr10_80444503_80444654	0.10	Tcf3	transcription factor 3	10931	0.09
chr9_107738378_107738568	0.10	Rbm5	RNA binding motif protein 5	5761	0.11
chr9_52056529_52056697	0.10	Rdx	radixin	8342	0.19
chr8_104443177_104443346	0.10	Dync1li2	dynein, cytoplasmic 1 light intermediate chain 2	214	0.83
chr2_31513768_31514291	0.10	Ass1	argininosuccinate synthetase 1	4461	0.2
chr6_145606729_145606899	0.10	Lmntd1	lamin tail domain containing 1	7155	0.21
chr17_25068673_25068863	0.10	Tmem204	transmembrane protein 204	9456	0.11
chr2_180788221_180788717	0.10	Bhlhe23	basic helix-loop-helix family, member e23	11569	0.11
chrX_108664177_108664328	0.10	Gm379	predicted gene 379	203	0.97
chr8_68277116_68277418	0.10	Sh2d4a	SH2 domain containing 4A	700	0.69
chr17_34733622_34734232	0.10	C4b	complement component 4B (Chido blood group)	2172	0.12
chr2_31491761_31492352	0.10	Ass1	argininosuccinate synthetase 1	5716	0.2
chr2_167148083_167148259	0.10	1110018N20Rik	RIKEN cDNA 1110018N20 gene	40531	0.08
chr8_93270889_93271065	0.10	Ces1f	carboxylesterase 1F	3572	0.18
chr5_121761085_121761315	0.10	Atxn2	ataxin 2	12004	0.12
chr7_30943687_30943953	0.10	Hamp	hepcidin antimicrobial peptide	212	0.82
chr11_69122450_69122661	0.10	9130213A22Rik	RIKEN cDNA 9130213A22 gene	34	0.93
chr8_124273757_124274124	0.10	Galnt2	polypeptide N-acetylgalactosaminyltransferase 2	21163	0.15
chr14_120534643_120535027	0.10	Rap2a	RAS related protein 2a	56391	0.14
chr5_8988023_8988336	0.10	Crot	carnitine O-octanoyltransferase	6035	0.13
chr15_75996647_75996807	0.10	Mapk15	mitogen-activated protein kinase 15	14	0.94
chr14_8251423_8251762	0.10	Acox2	acyl-Coenzyme A oxidase 2, branched chain	1930	0.34
chr2_167877367_167877523	0.10	Gm14319	predicted gene 14319	18860	0.16
chr16_11034212_11034466	0.10	Gm10832	predicted gene 10832	2383	0.16
chr17_28279922_28280073	0.09	Ppard	peroxisome proliferator activator receptor delta	7878	0.11
chr7_28732426_28732636	0.09	Fbxo17	F-box protein 17	31	0.95
chr6_117178128_117178348	0.09	Cxcl12	chemokine (C-X-C motif) ligand 12	9661	0.18
chr9_77964186_77964368	0.09	Elovl5	ELOVL family member 5, elongation of long chain fatty acids (yeast)	22986	0.11
chr6_29539642_29539820	0.09	Irf5	interferon regulatory factor 5	1415	0.29
chr1_190164468_190164683	0.09	Gm28172	predicted gene 28172	4095	0.21
chr13_96661137_96661370	0.09	Hmgcr	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	4586	0.17
chr11_109616366_109616667	0.09	Gm11685	predicted gene 11685	196	0.93
chr8_126498607_126498804	0.09	Gm6091	predicted pseudogene 6091	22293	0.18
chr2_180756949_180757112	0.09	Gm14343	predicted gene 14343	18373	0.1
chr2_48411517_48411668	0.09	Gm13472	predicted gene 13472	23555	0.19
chr16_23974024_23974210	0.09	Bcl6	B cell leukemia/lymphoma 6	1737	0.33
chr13_37761078_37761249	0.09	Gm31600	predicted gene, 31600	585	0.68
chr12_108292499_108292690	0.09	Hhipl1	hedgehog interacting protein-like 1	13676	0.15
chr16_67621078_67621243	0.09	Cadm2	cell adhesion molecule 2	252	0.95
chr11_119969786_119969965	0.09	Baiap2	brain-specific angiogenesis inhibitor 1-associated protein 2	9854	0.11
chr11_7136281_7136476	0.09	Adcy1	adenylate cyclase 1	23504	0.18
chr2_173161537_173161720	0.09	Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	8546	0.17
chr11_120012134_120012364	0.09	Aatk	apoptosis-associated tyrosine kinase	159	0.9
chr5_8962841_8962998	0.09	Abcb4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	4367	0.15
chr6_22037034_22037204	0.09	Cped1	cadherin-like and PC-esterase domain containing 1	11176	0.27
chr11_97449921_97450124	0.09	Arhgap23	Rho GTPase activating protein 23	138	0.95
chr1_39070328_39070509	0.09	Gm37821	predicted gene, 37821	12781	0.17
chr4_44994891_44995176	0.09	Grhpr	glyoxylate reductase/hydroxypyruvate reductase	13533	0.1
chr9_67842866_67843237	0.09	Vps13c	vacuolar protein sorting 13C	2639	0.27
chr18_46651026_46651177	0.09	Gm3734	predicted gene 3734	20294	0.14
chr19_56652542_56652727	0.09	Gm32441	predicted gene, 32441	11977	0.17
chr1_67195779_67195930	0.09	Gm15668	predicted gene 15668	53346	0.13
chr3_152478706_152478877	0.09	Ak5	adenylate kinase 5	276	0.91
chr19_3451534_3452133	0.09	Ppp6r3	protein phosphatase 6, regulatory subunit 3	19172	0.12
chr4_137795816_137796289	0.09	Alpl	alkaline phosphatase, liver/bone/kidney	178	0.96
chr7_141335382_141335533	0.09	Tmem80	transmembrane protein 80	1799	0.16
chr4_63494908_63495098	0.09	Whrn	whirlin	244	0.91
chr19_37509643_37509826	0.09	Exoc6	exocyst complex component 6	11145	0.17
chr9_83834067_83834712	0.09	Ttk	Ttk protein kinase	300	0.91
chr8_90834012_90834186	0.09	Chd9	chromodomain helicase DNA binding protein 9	5243	0.14
chr9_110985950_110986443	0.09	1700061E17Rik	RIKEN cDNA 1700061E17 gene	5	0.94
chr6_72360494_72360859	0.09	Rnf181	ring finger protein 181	391	0.72
chr2_26593869_26594069	0.09	Egfl7	EGF-like domain 7	1822	0.16
chr2_103472788_103473367	0.09	Cat	catalase	12048	0.18
chr15_79002341_79002492	0.09	Mir6956	microRNA 6956	193	0.52
chr19_42602482_42602861	0.09	Loxl4	lysyl oxidase-like 4	650	0.71
chr11_117964790_117965236	0.09	Socs3	suppressor of cytokine signaling 3	4173	0.16
chr10_122454632_122454783	0.09	Gm48878	predicted gene, 48878	575	0.76
chr5_140389137_140389453	0.09	Snx8	sorting nexin 8	33	0.97
chr2_32414031_32414217	0.09	Slc25a25	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25	2447	0.14
chr8_106606041_106606388	0.09	Cdh1	cadherin 1	2071	0.29
chr5_120483296_120483855	0.09	Gm15690	predicted gene 15690	2672	0.15
chr3_75950402_75950574	0.09	Gm37685	predicted gene, 37685	1636	0.35
chr12_112675159_112675325	0.09	Akt1	thymoma viral proto-oncogene 1	358	0.75
chr3_86002499_86002650	0.09	Prss48	protease, serine 48	83	0.96
chr8_123653291_123653442	0.09	Rhou	ras homolog family member U	563	0.38
chr2_93477672_93477838	0.09	Gm10804	predicted gene 10804	9316	0.19
chr5_87080846_87081015	0.09	Ugt2b36	UDP glucuronosyltransferase 2 family, polypeptide B36	10227	0.11
chr2_122775480_122775660	0.08	Sqor	sulfide quinone oxidoreductase	3852	0.22
chr11_102214881_102215057	0.08	Hdac5	histone deacetylase 5	3959	0.11
chr8_46512530_46512928	0.08	Acsl1	acyl-CoA synthetase long-chain family member 1	14057	0.15
chr14_34675574_34675754	0.08	Wapl	WAPL cohesin release factor	1491	0.26
chr6_72233008_72233332	0.08	Atoh8	atonal bHLH transcription factor 8	1367	0.39
chr3_69403326_69403495	0.08	Gm17213	predicted gene 17213	28958	0.17
chr11_85846806_85847022	0.08	Gm11444	predicted gene 11444	3419	0.17
chr3_84639824_84639982	0.08	Tmem154	transmembrane protein 154	26289	0.17
chr11_78157696_78157847	0.08	Traf4	TNF receptor associated factor 4	7745	0.07
chr13_96749686_96749877	0.08	Ankrd31	ankyrin repeat domain 31	1249	0.45
chr17_56207962_56208313	0.08	Dpp9	dipeptidylpeptidase 9	1071	0.32
chr3_67262698_67262957	0.08	Mlf1	myeloid leukemia factor 1	111270	0.06
chr5_33901574_33901762	0.08	Mir7024	microRNA 7024	2697	0.18
chr12_84221379_84221549	0.08	Elmsan1	ELM2 and Myb/SANT-like domain containing 1	2583	0.16
chr7_121907300_121907714	0.08	Scnn1b	sodium channel, nonvoltage-gated 1 beta	8279	0.18
chr16_18069271_18069422	0.08	Dgcr6	DiGeorge syndrome critical region gene 6	134	0.94
chr13_7414710_7414870	0.08	Gm36074	predicted gene, 36074	31719	0.23
chr5_93250297_93250457	0.08	Ccng2	cyclin G2	16880	0.14
chr5_115575131_115575282	0.08	Mir7029	microRNA 7029	5743	0.11
chr2_163551700_163552131	0.08	Hnf4a	hepatic nuclear factor 4, alpha	1832	0.25
chr5_123977607_123977811	0.08	Hip1r	huntingtin interacting protein 1 related	2545	0.16
chr8_14257136_14257302	0.08	Gm26184	predicted gene, 26184	16092	0.22
chr1_134955632_134955799	0.08	Ppp1r12b	protein phosphatase 1, regulatory subunit 12B	136	0.96
chr1_36512638_36512794	0.08	Cnnm3	cyclin M3	381	0.72
chr2_32678870_32679034	0.08	Gm26236	predicted gene, 26236	3843	0.08
chr5_114606575_114606726	0.08	Trpv4	transient receptor potential cation channel, subfamily V, member 4	23988	0.13
chr2_110007906_110008057	0.08	Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	7453	0.19
chr18_46718177_46718358	0.08	Cdo1	cysteine dioxygenase 1, cytosolic	9762	0.13
chr15_4727530_4727980	0.08	C6	complement component 6	539	0.84
chr8_40187640_40187799	0.08	Fgf20	fibroblast growth factor 20	99234	0.07
chr8_121573324_121573508	0.08	Fbxo31	F-box protein 31	5331	0.12
chr19_45036974_45037129	0.08	Pdzd7	PDZ domain containing 7	7036	0.1
chr11_101070404_101070591	0.08	Naglu	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	485	0.62
chr18_4970911_4971104	0.08	Svil	supervillin	22806	0.26
chr1_74047431_74047619	0.08	Tns1	tensin 1	10368	0.21
chr3_129970893_129971067	0.08	Mcub	mitochondrial calcium uniporter dominant negative beta subunit	774	0.62
chr11_115608626_115608777	0.08	Mif4gd	MIF4G domain containing	3425	0.11
chr17_12418655_12418810	0.08	Plg	plasminogen	40073	0.12
chr15_102006414_102006639	0.08	Krt8	keratin 8	2044	0.19
chr6_133105397_133105578	0.08	Smim10l1	small integral membrane protein 10 like 1	5	0.95
chr10_19525625_19525776	0.08	Gm48563	predicted gene, 48563	3050	0.27
chr8_70182055_70182225	0.08	Tmem161a	transmembrane protein 161A	1601	0.22
chr3_84647383_84647687	0.08	Tmem154	transmembrane protein 154	18657	0.2
chr2_32727754_32727916	0.08	Sh2d3c	SH2 domain containing 3C	129	0.89
chr15_67116763_67117052	0.08	St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	2915	0.34
chr14_30922623_30922783	0.08	Itih3	inter-alpha trypsin inhibitor, heavy chain 3	846	0.45
chr10_94055869_94056059	0.08	Fgd6	FYVE, RhoGEF and PH domain containing 6	16578	0.11
chr1_182609269_182609652	0.08	Capn8	calpain 8	44422	0.12
chr7_78782525_78782681	0.08	Mrpl46	mitochondrial ribosomal protein L46	486	0.44
chr8_111745534_111745719	0.08	Bcar1	breast cancer anti-estrogen resistance 1	1817	0.34
chr6_72117206_72117587	0.08	St3gal5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	2164	0.2
chr2_158768137_158768288	0.07	Fam83d	family with sequence similarity 83, member D	119	0.96
chr15_75981322_75981497	0.07	Ccdc166	coiled-coil domain containing 166	1033	0.28
chr13_37778325_37778511	0.07	Rreb1	ras responsive element binding protein 1	18	0.97
chr18_75818786_75819091	0.07	Zbtb7c	zinc finger and BTB domain containing 7C	1240	0.52
chr9_113127551_113127725	0.07	Gm36251	predicted gene, 36251	4609	0.31
chr12_8000122_8000489	0.07	Apob	apolipoprotein B	12054	0.22
chr17_31908788_31908992	0.07	2310015A16Rik	RIKEN cDNA 2310015A16 gene	139	0.94
chr10_94514734_94514917	0.07	Tmcc3	transmembrane and coiled coil domains 3	32	0.98
chr1_164210089_164210240	0.07	Slc19a2	solute carrier family 19 (thiamine transporter), member 2	38882	0.1
chr4_48125260_48125479	0.07	Stx17	syntaxin 17	434	0.87
chrX_74023375_74023542	0.07	Irak1	interleukin-1 receptor-associated kinase 1	50	0.58

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Ascl2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.1	GO:0019448	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.1	GO:0010963	regulation of L-arginine import(GO:0010963)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:1903525	regulation of membrane tubulation(GO:1903525)
0.0	0.1	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:1904222	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0	0.1	GO:0032763	regulation of mast cell cytokine production(GO:0032763)
0.0	0.1	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0	0.1	GO:0009202	deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0	0.1	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.1	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.1	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.0	GO:0003221	right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.0	0.2	GO:2000392	regulation of lamellipodium morphogenesis(GO:2000392)
0.0	0.1	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0	0.1	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.1	GO:0006563	L-serine metabolic process(GO:0006563)
0.0	0.1	GO:0042126	nitrate metabolic process(GO:0042126)
0.0	0.1	GO:0033026	negative regulation of mast cell apoptotic process(GO:0033026)
0.0	0.1	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0	0.1	GO:1901420	negative regulation of response to alcohol(GO:1901420)
0.0	0.1	GO:0015770	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.1	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.0	0.1	GO:0006114	glycerol biosynthetic process(GO:0006114)
0.0	0.1	GO:0042760	very long-chain fatty acid catabolic process(GO:0042760)
0.0	0.1	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0	0.1	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.1	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.1	GO:1900194	negative regulation of oocyte maturation(GO:1900194)
0.0	0.1	GO:0032079	positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.0	0.1	GO:2000259	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.0	GO:0071476	cellular hypotonic response(GO:0071476)
0.0	0.0	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.1	GO:0032534	regulation of microvillus assembly(GO:0032534)
0.0	0.1	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	0.0	GO:0044860	protein localization to plasma membrane raft(GO:0044860)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.0	GO:0006553	lysine metabolic process(GO:0006553)
0.0	0.1	GO:0097460	ferrous iron import into cell(GO:0097460)
0.0	0.1	GO:0045217	cell-cell junction maintenance(GO:0045217)
0.0	0.1	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.1	GO:0045404	positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.1	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0	0.1	GO:0071404	cellular response to low-density lipoprotein particle stimulus(GO:0071404)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:0002017	regulation of blood volume by renal aldosterone(GO:0002017)
0.0	0.0	GO:0009826	unidimensional cell growth(GO:0009826)
0.0	0.0	GO:2000598	regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.0	GO:0070346	positive regulation of fat cell proliferation(GO:0070346)
0.0	0.1	GO:0032482	Rab protein signal transduction(GO:0032482)
0.0	0.1	GO:0044539	long-chain fatty acid import(GO:0044539)
0.0	0.0	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0	0.1	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.0	0.1	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0	0.1	GO:0046618	drug export(GO:0046618)
0.0	0.0	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0	0.0	GO:0010288	response to lead ion(GO:0010288)
0.0	0.0	GO:0018103	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.0	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.0	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.0	GO:0060066	oviduct development(GO:0060066)
0.0	0.0	GO:0010725	regulation of primitive erythrocyte differentiation(GO:0010725)
0.0	0.1	GO:1902894	negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0	0.1	GO:0045656	negative regulation of monocyte differentiation(GO:0045656)
0.0	0.1	GO:0097466	glycoprotein ERAD pathway(GO:0097466) response to glycoprotein(GO:1904587)
0.0	0.0	GO:0018243	protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.0	GO:0000715	nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0	0.0	GO:0039663	fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0	0.0	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0	0.0	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.0	GO:2001206	positive regulation of osteoclast development(GO:2001206)
0.0	0.0	GO:1902988	neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996)
0.0	0.1	GO:0034498	early endosome to Golgi transport(GO:0034498)
0.0	0.1	GO:0030828	positive regulation of cGMP biosynthetic process(GO:0030828)
0.0	0.0	GO:0042851	L-alanine metabolic process(GO:0042851)
0.0	0.0	GO:1901656	glycoside transport(GO:1901656)
0.0	0.0	GO:2000680	regulation of rubidium ion transport(GO:2000680)
0.0	0.0	GO:0002426	immunoglobulin production in mucosal tissue(GO:0002426)
0.0	0.1	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	0.0	GO:0010835	regulation of protein ADP-ribosylation(GO:0010835)
0.0	0.0	GO:1901628	positive regulation of postsynaptic membrane organization(GO:1901628) regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0	0.1	GO:0051601	exocyst localization(GO:0051601)
0.0	0.0	GO:0032788	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.0	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0	0.0	GO:0032417	positive regulation of sodium:proton antiporter activity(GO:0032417)
0.0	0.0	GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340)
0.0	0.0	GO:0060355	positive regulation of cell adhesion molecule production(GO:0060355)
0.0	0.0	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.0	0.0	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.0	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0002177	manchette(GO:0002177)
0.2	GO:0070852	cell body fiber(GO:0070852)
0.1	GO:0002142	stereocilia ankle link complex(GO:0002142)
0.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0	GO:0036449	microtubule minus-end(GO:0036449)
0.0	GO:0090498	extrinsic component of Golgi membrane(GO:0090498)
0.1	GO:0005955	calcineurin complex(GO:0005955)
0.1	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.0	GO:1990812	growth cone filopodium(GO:1990812)
0.0	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110)
0.1	GO:0065010	extracellular membrane-bounded organelle(GO:0065010)
0.0	GO:0000811	GINS complex(GO:0000811)
0.0	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	GO:1990696	USH2 complex(GO:1990696)
0.1	GO:0097431	mitotic spindle pole(GO:0097431)
0.0	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.1	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.1	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.1	GO:0061513	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1	GO:0010853	cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.1	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.1	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	GO:0016838	carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.1	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.3	GO:0015643	toxic substance binding(GO:0015643)
0.1	GO:0050692	DBD domain binding(GO:0050692)
0.1	GO:0004104	cholinesterase activity(GO:0004104)
0.1	GO:0010484	H3 histone acetyltransferase activity(GO:0010484)
0.1	GO:0008515	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	GO:0015141	succinate transmembrane transporter activity(GO:0015141)
0.1	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.1	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1	GO:0009041	uridylate kinase activity(GO:0009041)
0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.0	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.1	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0	GO:0070905	serine binding(GO:0070905)
0.0	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	GO:0102007	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.1	GO:0036374	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.0	GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1	GO:0009374	biotin binding(GO:0009374)
0.1	GO:1990459	transferrin receptor binding(GO:1990459)
0.0	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.1	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.0	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.1	GO:0050649	testosterone 6-beta-hydroxylase activity(GO:0050649)
0.1	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.0	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.0	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.0	GO:0016453	acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.0	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.0	GO:0000253	3-keto sterol reductase activity(GO:0000253)
0.0	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	ST GAQ PATHWAY	G alpha q Pathway
0.0	PID IFNG PATHWAY	IFN-gamma pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	REACTOME KINESINS	Genes involved in Kinesins
0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol