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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Atf7_E4f1

Z-value: 0.77

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Transcription factors associated with Atf7_E4f1

Gene Symbol	Gene ID	Gene Info
Atf7 Ensembl NCBI MGI UniProt	ENSMUSG00000052414.9	activating transcription factor 7
Atf7 Ensembl NCBI MGI UniProt	ENSMUSG00000071584.1	activating transcription factor 7
E4f1 Ensembl NCBI MGI UniProt	ENSMUSG00000024137.8	E4F transcription factor 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr17_24469959_24470159	E4f1	132	0.699941	-0.92	9.9e-03	Click!
chr17_24470160_24470458	E4f1	4	0.544263	-0.84	3.7e-02	Click!
chr17_24453368_24453643	E4f1	1781	0.146839	0.75	8.4e-02	Click!
chr17_24455257_24455550	E4f1	11	0.934138	-0.67	1.4e-01	Click!
chr17_24454731_24454905	E4f1	468	0.582543	-0.67	1.5e-01	Click!

Activity of the Atf7_E4f1 motif across conditions

Conditions sorted by the z-value of the Atf7_E4f1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_75173089_75173918	1.28	Mir212	microRNA 212	115	0.56
chr3_51255928_51256079	0.83	Elf2	E74-like factor 2	4238	0.15
chr4_141858646_141858827	0.71	Ctrc	chymotrypsin C (caldecrin)	12377	0.1
chr3_146630472_146630703	0.64	Gm16325	predicted gene 16325	11345	0.12
chr8_40881703_40881854	0.57	Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	6830	0.17
chr7_97788226_97788577	0.57	Pak1	p21 (RAC1) activated kinase 1	140	0.96
chr2_156065132_156065865	0.56	Spag4	sperm associated antigen 4	55	0.94
chr9_42464439_42464590	0.55	Tbcel	tubulin folding cofactor E-like	3053	0.23
chr10_17948008_17948419	0.55	Heca	hdc homolog, cell cycle regulator	146	0.97
chr9_55264900_55265092	0.54	Nrg4	neuregulin 4	18576	0.16
chr3_27751423_27751574	0.53	Fndc3b	fibronectin type III domain containing 3B	40191	0.19
chr19_61226929_61227456	0.49	Csf2ra	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	44	0.96
chr18_74939611_74939786	0.49	Gm18786	predicted gene, 18786	3418	0.13
chr14_61680870_61681697	0.47	Gm37472	predicted gene, 37472	211	0.83
chr2_180589607_180589819	0.47	Ogfr	opioid growth factor receptor	251	0.89
chr12_32766682_32766844	0.46	Nampt	nicotinamide phosphoribosyltransferase	52782	0.12
chr15_102103356_102103597	0.44	Tns2	tensin 2	488	0.69
chr17_70668731_70668893	0.43	5031415H12Rik	RIKEN cDNA 5031415H12 gene	86770	0.08
chr2_72741614_72741840	0.43	6430710C18Rik	RIKEN cDNA 6430710C18 gene	9126	0.22
chr4_101741736_101741946	0.42	Lepr	leptin receptor	24434	0.19
chr5_92607049_92607221	0.39	Stbd1	starch binding domain 1	4067	0.19
chr11_16852969_16853170	0.39	Egfros	epidermal growth factor receptor, opposite strand	22367	0.17
chr10_69204774_69204937	0.38	Rhobtb1	Rho-related BTB domain containing 1	3697	0.22
chr7_97757551_97757739	0.38	Aqp11	aquaporin 11	19356	0.15
chr15_59032105_59032256	0.37	Mtss1	MTSS I-BAR domain containing 1	8416	0.21
chr2_8124301_8124468	0.37	Gm13254	predicted gene 13254	23481	0.29
chr2_155070811_155070993	0.36	Gm45609	predicted gene 45609	3279	0.17
chr14_120477462_120478025	0.36	Rap2a	RAS related protein 2a	701	0.77
chr14_102015145_102015320	0.36	Gm5854	predicted gene 5854	32469	0.22
chr1_54492445_54492606	0.35	Gm36955	predicted gene, 36955	27745	0.14
chr15_58972603_58972890	0.35	Mtss1	MTSS I-BAR domain containing 1	207	0.92
chr18_62095425_62095728	0.35	Gm41750	predicted gene, 41750	47042	0.14
chr3_102677050_102677222	0.34	Gm19202	predicted gene, 19202	9581	0.14
chr6_90599935_90600097	0.34	Gm15756	predicted gene 15756	68	0.96
chr16_96127404_96127899	0.34	Hmgn1	high mobility group nucleosomal binding domain 1	47	0.96
chr7_118704359_118704549	0.34	Gde1	glycerophosphodiester phosphodiesterase 1	926	0.45
chr10_89492629_89492900	0.34	Nr1h4	nuclear receptor subfamily 1, group H, member 4	13885	0.21
chr10_86885775_86886048	0.34	Stab2	stabilin 2	162	0.93
chr7_19933617_19933791	0.34	Igsf23	immunoglobulin superfamily, member 23	11194	0.07
chr9_106238027_106238241	0.33	Alas1	aminolevulinic acid synthase 1	596	0.58
chr11_16850729_16850984	0.33	Egfros	epidermal growth factor receptor, opposite strand	20154	0.18
chrY_90783982_90784262	0.33	Gm47283	predicted gene, 47283	616	0.72
chr9_48596792_48597151	0.33	Nnmt	nicotinamide N-methyltransferase	404	0.88
chr11_3443162_3443363	0.33	Rnf185	ring finger protein 185	9072	0.1
chr3_138288275_138288480	0.33	Adh1	alcohol dehydrogenase 1 (class I)	10726	0.12
chr17_27820677_27821072	0.32	Ilrun	inflammation and lipid regulator with UBA-like and NBR1-like domains	226	0.89
chr6_27782346_27782517	0.32	Gm26310	predicted gene, 26310	114344	0.07
chr10_87926267_87926684	0.32	Tyms-ps	thymidylate synthase, pseudogene	40372	0.13
chr2_9990244_9990418	0.31	Taf3	TATA-box binding protein associated factor 3	36674	0.1
chr10_80622017_80622180	0.31	Csnk1g2	casein kinase 1, gamma 2	740	0.4
chr5_138863743_138864096	0.31	Gm5294	predicted gene 5294	43839	0.13
chr4_60380015_60380268	0.31	Mup-ps29	major urinary protein, pseudogene 29	4353	0.18
chr13_109536856_109537007	0.31	Pde4d	phosphodiesterase 4D, cAMP specific	44474	0.21
chr2_52603393_52603554	0.30	Bloc1s2-ps	biogenesis of lysosomal organelles complex-1, subunit 2, pseudogene	16281	0.2
chr15_85599225_85599378	0.30	Wnt7b	wingless-type MMTV integration site family, member 7B	16828	0.15
chr4_61740192_61740453	0.29	Gm12573	predicted gene 12573	9753	0.14
chr15_12321006_12321530	0.29	Golph3	golgi phosphoprotein 3	182	0.84
chr5_135685581_135685753	0.29	Por	P450 (cytochrome) oxidoreductase	3369	0.13
chr4_61401423_61401691	0.29	Mup15	major urinary protein 15	38186	0.14
chr14_69411185_69411411	0.29	Gm38378	predicted gene, 38378	13527	0.11
chr4_149854310_149854480	0.28	Gm47301	predicted gene, 47301	36631	0.09
chr3_148681139_148681436	0.28	Gm43575	predicted gene 43575	28227	0.24
chr8_111145184_111145817	0.28	9430091E24Rik	RIKEN cDNA 9430091E24 gene	20	0.97
chr8_111630041_111630248	0.28	Ldhd	lactate dehydrogenase D	191	0.93
chr10_75783826_75784124	0.28	Gstt3	glutathione S-transferase, theta 3	2561	0.13
chr4_139198021_139198318	0.27	Capzb	capping protein (actin filament) muscle Z-line, beta	1098	0.44
chr7_139388680_139389161	0.27	Inpp5a	inositol polyphosphate-5-phosphatase A	189	0.96
chr15_80836341_80836511	0.27	Tnrc6b	trinucleotide repeat containing 6b	37711	0.15
chr14_75242017_75242184	0.27	Cpb2	carboxypeptidase B2 (plasma)	187	0.93
chr3_10439906_10440215	0.27	Snx16	sorting nexin 16	27	0.98
chr9_21367416_21367785	0.26	Ilf3	interleukin enhancer binding factor 3	271	0.81
chr15_58941890_58942087	0.26	Ndufb9	NADH:ubiquinone oxidoreductase subunit B9	8180	0.13
chr2_102154219_102154407	0.26	Ldlrad3	low density lipoprotein receptor class A domain containing 3	16194	0.19
chr2_58780980_58781131	0.26	Upp2	uridine phosphorylase 2	15730	0.2
chr16_31521897_31522062	0.26	Gm46560	predicted gene, 46560	13592	0.16
chr12_59219708_59220018	0.26	Fbxo33	F-box protein 33	138	0.95
chr11_49837892_49838056	0.26	Mapk9	mitogen-activated protein kinase 9	8777	0.16
chr11_88242033_88242214	0.26	Gm38534	predicted gene, 38534	11245	0.17
chr2_79448009_79448160	0.26	Neurod1	neurogenic differentiation 1	8667	0.21
chr3_51234740_51234908	0.25	Gm38357	predicted gene, 38357	2907	0.19
chr6_145855716_145856207	0.25	Gm43909	predicted gene, 43909	7336	0.17
chr4_11966482_11966677	0.25	1700123M08Rik	RIKEN cDNA 1700123M08 gene	5	0.62
chr14_67072405_67072747	0.25	Ppp2r2a	protein phosphatase 2, regulatory subunit B, alpha	132	0.95
chr4_102432201_102432362	0.25	Pde4b	phosphodiesterase 4B, cAMP specific	2234	0.46
chr2_57114946_57115097	0.25	Nr4a2	nuclear receptor subfamily 4, group A, member 2	17	0.98
chr4_84540692_84540849	0.25	Bnc2	basonuclin 2	5520	0.32
chr8_70302451_70302610	0.25	Cope	coatomer protein complex, subunit epsilon	12	0.5
chr10_124731285_124731709	0.25	Gm47839	predicted gene, 47839	113984	0.07
chr9_23224794_23225147	0.25	Bmper	BMP-binding endothelial regulator	1684	0.55
chr10_20952125_20952679	0.25	Ahi1	Abelson helper integration site 1	145	0.97
chr4_141060479_141060918	0.25	Crocc	ciliary rootlet coiled-coil, rootletin	148	0.92
chr6_14900560_14901049	0.25	Foxp2	forkhead box P2	545	0.87
chr10_108360046_108360218	0.25	Gm23105	predicted gene, 23105	3533	0.25
chr11_16865620_16865819	0.25	Egfr	epidermal growth factor receptor	12431	0.2
chr3_60965282_60965682	0.25	P2ry1	purinergic receptor P2Y, G-protein coupled 1	37313	0.16
chr4_128947381_128947553	0.25	Gm15904	predicted gene 15904	11462	0.15
chr13_107646164_107646517	0.25	Gm32090	predicted gene, 32090	33491	0.16
chr3_145118680_145119047	0.24	Odf2l	outer dense fiber of sperm tails 2-like	111	0.97
chr5_150572501_150572662	0.24	Gm43690	predicted gene 43690	1483	0.19
chr13_53001712_53001870	0.24	Gm33424	predicted gene, 33424	14411	0.16
chr2_11706768_11706947	0.24	Il15ra	interleukin 15 receptor, alpha chain	1009	0.47
chr17_8792731_8792886	0.24	Pde10a	phosphodiesterase 10A	8885	0.24
chr9_85413933_85414088	0.24	Gm48833	predicted gene, 48833	5148	0.22
chr15_38519170_38519716	0.24	Azin1	antizyme inhibitor 1	177	0.84
chr12_104856908_104857124	0.23	4930408O17Rik	RIKEN cDNA 4930408O17 gene	355	0.86
chr19_43463068_43463222	0.23	Gm47938	predicted gene, 47938	6613	0.14
chr4_108085569_108085740	0.23	Mir6397	microRNA 6397	1703	0.28
chr11_4190861_4191026	0.23	Tbc1d10a	TBC1 domain family, member 10a	4121	0.11
chr18_31711636_31711807	0.23	Gm50060	predicted gene, 50060	26994	0.14
chr3_97226229_97226380	0.23	Bcl9	B cell CLL/lymphoma 9	1060	0.5
chr10_127936742_127936977	0.23	Gm15900	predicted gene 15900	11701	0.09
chr5_32713672_32713870	0.23	Gm43852	predicted gene 43852	217	0.89
chr2_166197123_166197281	0.23	Gm11466	predicted gene 11466	6340	0.16
chr18_11657291_11657484	0.23	Rbbp8	retinoblastoma binding protein 8, endonuclease	4	0.87
chr2_6165912_6166067	0.23	A230108P19Rik	RIKEN cDNA A230108P19 gene	27262	0.12
chr13_95639510_95639665	0.23	F2r	coagulation factor II (thrombin) receptor	21100	0.13
chr15_97025909_97026070	0.23	Slc38a4	solute carrier family 38, member 4	5222	0.3
chr3_118652951_118653308	0.23	Dpyd	dihydropyrimidine dehydrogenase	90943	0.08
chr1_74066477_74066680	0.23	Tns1	tensin 1	24773	0.17
chr2_167777355_167777522	0.23	Gm14321	predicted gene 14321	29	0.97
chr3_108840435_108840756	0.23	Stxbp3	syntaxin binding protein 3	69	0.97
chr12_91846606_91846757	0.23	Sel1l	sel-1 suppressor of lin-12-like (C. elegans)	2448	0.23
chr11_94044111_94044443	0.23	Spag9	sperm associated antigen 9	9	0.98
chr1_190919860_190920026	0.23	Angel2	angel homolog 2	5169	0.17
chr18_33214764_33214929	0.22	Stard4	StAR-related lipid transfer (START) domain containing 4	984	0.69
chr14_120312913_120313266	0.22	Mbnl2	muscleblind like splicing factor 2	6633	0.28
chr3_148899467_148899618	0.22	Adgrl2	adhesion G protein-coupled receptor L2	55093	0.14
chrX_170009083_170009242	0.22	Erdr1	erythroid differentiation regulator 1	497	0.77
chr19_17617854_17618016	0.22	Gm17819	predicted gene, 17819	74828	0.11
chr17_53478848_53479280	0.21	Rab5a	RAB5A, member RAS oncogene family	170	0.93
chr19_10122335_10122508	0.21	Fads2	fatty acid desaturase 2	20675	0.12
chr14_69629438_69629774	0.21	Gm27177	predicted gene 27177	10668	0.12
chr11_79254630_79254838	0.21	Wsb1	WD repeat and SOCS box-containing 1	63	0.97
chr12_54459633_54459834	0.21	Gm7557	predicted gene 7557	29335	0.13
chr17_34024597_34024949	0.21	Ring1	ring finger protein 1	93	0.48
chr4_137919760_137920083	0.21	Ece1	endothelin converting enzyme 1	6239	0.22
chr18_73844340_73844698	0.21	Mro	maestro	14866	0.2
chr17_5261920_5262119	0.21	Gm29050	predicted gene 29050	126744	0.05
chr15_33687773_33687947	0.20	Tspyl5	testis-specific protein, Y-encoded-like 5	24	0.98
chr14_66103708_66103859	0.20	Ephx2	epoxide hydrolase 2, cytoplasmic	6877	0.17
chr2_60124236_60125022	0.20	Gm13620	predicted gene 13620	467	0.65
chr3_21878552_21878734	0.20	7530428D23Rik	RIKEN cDNA 7530428D23 gene	77870	0.1
chr15_67153583_67153747	0.20	St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	23047	0.23
chr2_20896513_20896664	0.20	Arhgap21	Rho GTPase activating protein 21	13359	0.21
chr16_16829274_16829425	0.20	Spag6l	sperm associated antigen 6-like	5	0.96
chr6_28981358_28981514	0.20	Gm3294	predicted gene 3294	198	0.95
chr8_76148011_76148197	0.20	Gm45742	predicted gene 45742	31077	0.21
chr7_25248454_25248809	0.20	Erf	Ets2 repressor factor	2099	0.14
chrY_90799049_90799217	0.20	Gm47283	predicted gene, 47283	8682	0.18
chr3_27145774_27146219	0.20	Ect2	ect2 oncogene	1205	0.44
chr8_60992984_60993275	0.20	Nek1	NIMA (never in mitosis gene a)-related expressed kinase 1	66	0.96
chr15_7175278_7175429	0.20	Lifr	LIF receptor alpha	21000	0.23
chr13_24948941_24949098	0.20	Gpld1	glycosylphosphatidylinositol specific phospholipase D1	5867	0.14
chr4_105218216_105218614	0.20	Plpp3	phospholipid phosphatase 3	61068	0.14
chr3_18151182_18151333	0.20	Gm23686	predicted gene, 23686	26368	0.2
chr9_96478340_96478816	0.19	Rnf7	ring finger protein 7	10	0.97
chr11_23140920_23141288	0.19	1700061J23Rik	RIKEN cDNA 1700061J23 gene	11036	0.18
chr19_44400352_44400581	0.19	Scd1	stearoyl-Coenzyme A desaturase 1	6224	0.15
chr1_164543147_164543444	0.19	D630023O14Rik	RIKEN cDNA D630023O14 gene	32160	0.13
chr11_90130089_90130271	0.19	Gm11494	predicted gene 11494	13444	0.19
chr2_58756221_58756376	0.19	Upp2	uridine phosphorylase 2	1086	0.54
chr12_119070550_119070715	0.19	Gm18921	predicted gene, 18921	3202	0.35
chr10_3973022_3973187	0.19	Mthfd1l	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	14	0.97
chr16_87128308_87128459	0.19	Gm32865	predicted gene, 32865	56	0.99
chr8_45975033_45975552	0.19	1700029J07Rik	RIKEN cDNA 1700029J07 gene	40	0.74
chr11_16786533_16786734	0.19	Egfr	epidermal growth factor receptor	34403	0.15
chr11_119105318_119105491	0.19	Gm11754	predicted gene 11754	6021	0.15
chr2_31476693_31476999	0.19	Ass1	argininosuccinate synthetase 1	6639	0.2
chr11_5900664_5900815	0.19	Gck	glucokinase	1348	0.27
chr4_108425790_108426145	0.19	Gpx7	glutathione peroxidase 7	19006	0.1
chr1_92473264_92473470	0.19	Ndufa10	NADH:ubiquinone oxidoreductase subunit A10	380	0.77
chr5_87574485_87574667	0.19	Sult1d1	sulfotransferase family 1D, member 1	5549	0.12
chr9_20492670_20492836	0.18	Zfp426	zinc finger protein 426	7	0.96
chr11_118723319_118723470	0.18	Rbfox3	RNA binding protein, fox-1 homolog (C. elegans) 3	37647	0.17
chr17_24168769_24169218	0.18	Atp6v0c	ATPase, H+ transporting, lysosomal V0 subunit C	73	0.93
chr3_129578277_129578428	0.18	Elovl6	ELOVL family member 6, elongation of long chain fatty acids (yeast)	25972	0.15
chr2_58794623_58794807	0.18	Upp2	uridine phosphorylase 2	29390	0.17
chr2_31742282_31742433	0.18	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	17586	0.14
chr9_43224415_43225053	0.18	Oaf	out at first homolog	358	0.84
chr5_125524109_125525122	0.18	Tmem132b	transmembrane protein 132B	7159	0.16
chr8_69192982_69193338	0.18	Lzts1	leucine zipper, putative tumor suppressor 1	8935	0.15
chr5_125521313_125521481	0.18	Aacs	acetoacetyl-CoA synthetase	6154	0.17
chr10_76997859_76998018	0.18	Gm35721	predicted gene, 35721	10631	0.12
chr15_101453443_101453620	0.18	Krt88	keratin 88	5787	0.08
chr10_106941491_106941653	0.18	Gm19007	predicted gene, 19007	7725	0.25
chr8_122306649_122307232	0.18	Zfpm1	zinc finger protein, multitype 1	380	0.82
chr16_43464306_43464503	0.18	Zbtb20	zinc finger and BTB domain containing 20	39210	0.15
chr2_26928748_26928911	0.18	Surf4	surfeit gene 4	4554	0.08
chr11_101302224_101302524	0.18	Becn1	beclin 1, autophagy related	88	0.9
chr3_31094797_31095132	0.17	Skil	SKI-like	94	0.97
chr16_33966968_33967146	0.17	Umps	uridine monophosphate synthetase	19	0.94
chr15_68363065_68363728	0.17	Gm20732	predicted gene 20732	220	0.9
chr2_38368865_38369094	0.17	Gm13584	predicted gene 13584	4999	0.16
chr13_64152199_64152545	0.17	Zfp367	zinc finger protein 367	113	0.63
chr9_105792281_105792501	0.17	Col6a6	collagen, type VI, alpha 6	17257	0.2
chr6_30304499_30304656	0.17	1700095J07Rik	RIKEN cDNA 1700095J07 gene	28	0.5
chr3_145924039_145924997	0.17	Bcl10	B cell leukemia/lymphoma 10	161	0.95
chr2_72160606_72160802	0.17	Rapgef4os1	Rap guanine nucleotide exchange factor (GEF) 4, opposite strand 1	11908	0.19
chr13_109485029_109485208	0.17	Pde4d	phosphodiesterase 4D, cAMP specific	42935	0.21
chr11_16889902_16890060	0.17	Egfr	epidermal growth factor receptor	11831	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf7_E4f1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0061535	glutamate secretion, neurotransmission(GO:0061535)
0.1	0.5	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.4	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.1	0.3	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.1	0.3	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.3	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.1	1.2	GO:0014041	regulation of neuron maturation(GO:0014041)
0.1	0.2	GO:0021538	epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1	0.2	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.1	0.5	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1	0.2	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1	0.1	GO:1904179	positive regulation of adipose tissue development(GO:1904179)
0.1	0.2	GO:0003186	tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195)
0.1	0.2	GO:0009174	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1	0.2	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0	0.1	GO:0019287	isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0	0.2	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.1	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.0	0.1	GO:0018879	biphenyl metabolic process(GO:0018879)
0.0	0.3	GO:0042297	vocal learning(GO:0042297) imitative learning(GO:0098596) learned vocalization behavior or vocal learning(GO:0098598)
0.0	0.2	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	0.2	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.1	GO:0003289	atrial septum primum morphogenesis(GO:0003289)
0.0	0.1	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.1	GO:0060125	negative regulation of growth hormone secretion(GO:0060125)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.2	GO:1902023	L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.0	0.1	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0	0.2	GO:0031052	programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052)
0.0	0.1	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
0.0	0.1	GO:1903753	negative regulation of p38MAPK cascade(GO:1903753)
0.0	0.1	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.2	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:1903751	regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.3	GO:0007288	sperm axoneme assembly(GO:0007288)
0.0	0.1	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0	0.2	GO:0043652	engulfment of apoptotic cell(GO:0043652)
0.0	0.4	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.1	GO:0003099	positive regulation of the force of heart contraction by epinephrine-norepinephrine(GO:0001997) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0	0.2	GO:0021942	radial glia guided migration of Purkinje cell(GO:0021942)
0.0	0.1	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.2	GO:0035845	photoreceptor cell outer segment organization(GO:0035845)
0.0	0.3	GO:0006622	protein targeting to lysosome(GO:0006622)
0.0	0.1	GO:1903999	negative regulation of eating behavior(GO:1903999)
0.0	0.1	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.1	GO:1900095	regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0	0.2	GO:0022615	protein to membrane docking(GO:0022615)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0	0.1	GO:0045585	regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.0	0.0	GO:1902996	neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996)
0.0	0.1	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.2	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.1	GO:0032202	telomere assembly(GO:0032202)
0.0	0.1	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0	0.1	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.0	GO:1902488	cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.0	0.1	GO:0006393	termination of mitochondrial transcription(GO:0006393)
0.0	0.2	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0	0.2	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0042078	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0	0.1	GO:0007042	lysosomal lumen acidification(GO:0007042)
0.0	0.1	GO:0002439	chronic inflammatory response to antigenic stimulus(GO:0002439)
0.0	0.1	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.0	0.1	GO:0036295	cellular response to increased oxygen levels(GO:0036295) cellular response to hyperoxia(GO:0071455)
0.0	0.1	GO:0009730	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.2	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.0	0.0	GO:0060620	regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.0	0.0	GO:0072053	renal inner medulla development(GO:0072053)
0.0	0.4	GO:0014850	response to muscle activity(GO:0014850)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.1	GO:0060178	regulation of exocyst localization(GO:0060178)
0.0	0.1	GO:0098789	pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0	0.2	GO:0045416	positive regulation of interleukin-8 biosynthetic process(GO:0045416)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237)
0.0	0.1	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.1	GO:0090160	Golgi to lysosome transport(GO:0090160)
0.0	0.2	GO:0090161	Golgi ribbon formation(GO:0090161)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.2	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0	0.2	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.0	GO:0098910	regulation of atrial cardiac muscle cell action potential(GO:0098910)
0.0	0.2	GO:0034435	steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.0	0.1	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.0	0.1	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.0	0.1	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.1	GO:0045541	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.2	GO:0014072	response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.0	0.0	GO:0097252	oligodendrocyte apoptotic process(GO:0097252)
0.0	0.1	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.2	GO:2000052	positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0	0.2	GO:0046543	development of secondary female sexual characteristics(GO:0046543)
0.0	0.2	GO:0045738	negative regulation of DNA repair(GO:0045738) negative regulation of double-strand break repair(GO:2000780)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.0	GO:0060375	regulation of mast cell differentiation(GO:0060375)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.0	GO:0097155	fasciculation of sensory neuron axon(GO:0097155)
0.0	0.0	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:1901301	regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0	0.0	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.0	0.0	GO:1903660	regulation of complement-dependent cytotoxicity(GO:1903659) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:0032825	positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.0	GO:0097167	circadian regulation of translation(GO:0097167)
0.0	0.1	GO:0070245	positive regulation of thymocyte apoptotic process(GO:0070245)
0.0	0.1	GO:0032304	negative regulation of icosanoid secretion(GO:0032304)
0.0	0.0	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.0	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0	0.1	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity(GO:0035509)
0.0	0.0	GO:1903261	regulation of serine phosphorylation of STAT3 protein(GO:1903261)
0.0	0.1	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:0060510	Type II pneumocyte differentiation(GO:0060510)
0.0	0.1	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.1	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.0	0.0	GO:1900108	negative regulation of nodal signaling pathway(GO:1900108)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.1	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.2	GO:2000001	regulation of DNA damage checkpoint(GO:2000001)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0031627	telomeric loop formation(GO:0031627)
0.0	0.0	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.0	GO:0001922	B-1 B cell homeostasis(GO:0001922)
0.0	0.1	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.1	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0097210	response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0	0.1	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0	0.1	GO:0034625	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.0	GO:1901896	positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.0	0.0	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.0	GO:0006407	rRNA export from nucleus(GO:0006407)
0.0	0.0	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	0.1	GO:0061299	retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0	0.0	GO:0060486	Clara cell differentiation(GO:0060486)
0.0	0.0	GO:0046340	diacylglycerol catabolic process(GO:0046340)
0.0	0.2	GO:0046325	negative regulation of glucose import(GO:0046325)
0.0	0.0	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.0	0.0	GO:0070094	positive regulation of glucagon secretion(GO:0070094)
0.0	0.0	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.0	GO:0071895	odontoblast differentiation(GO:0071895)
0.0	0.0	GO:0090240	positive regulation of histone H4 acetylation(GO:0090240)
0.0	0.0	GO:1903551	regulation of extracellular exosome assembly(GO:1903551)
0.0	0.0	GO:0043465	regulation of fermentation(GO:0043465) regulation of NAD metabolic process(GO:1902688) regulation of glucose catabolic process to lactate via pyruvate(GO:1904023)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.0	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.0	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.0	GO:0035609	C-terminal protein deglutamylation(GO:0035609)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.3	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
0.1	0.6	GO:0071437	invadopodium(GO:0071437)
0.1	0.3	GO:0045098	type III intermediate filament(GO:0045098)
0.1	0.2	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	0.2	GO:1990716	axonemal central apparatus(GO:1990716)
0.0	0.5	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.2	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.0	0.2	GO:0071203	WASH complex(GO:0071203)
0.0	0.2	GO:0008274	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0	0.2	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0	0.2	GO:0070820	tertiary granule(GO:0070820)
0.0	0.1	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.1	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.1	GO:1990423	RZZ complex(GO:1990423)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0097149	centralspindlin complex(GO:0097149)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.2	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0043293	apoptosome(GO:0043293)
0.0	0.1	GO:0035032	phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.2	GO:0036038	MKS complex(GO:0036038)
0.0	0.2	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0070187	telosome(GO:0070187)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0030122	AP-2 adaptor complex(GO:0030122)
0.0	0.1	GO:0097441	basilar dendrite(GO:0097441)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0071598	neuronal ribonucleoprotein granule(GO:0071598)
0.0	0.0	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.1	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0	0.2	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.0	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.2	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.1	GO:0005726	perichromatin fibrils(GO:0005726)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.1	GO:0045180	basal cortex(GO:0045180)
0.0	0.1	GO:0090576	RNA polymerase III transcription factor complex(GO:0090576)
0.0	0.1	GO:0000347	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.1	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.0	0.5	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	0.1	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.1	GO:0002199	zona pellucida receptor complex(GO:0002199)
0.0	0.1	GO:0070652	HAUS complex(GO:0070652)
0.0	0.1	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.3	GO:0042731	PH domain binding(GO:0042731)
0.1	0.3	GO:0004457	lactate dehydrogenase activity(GO:0004457)
0.1	0.3	GO:0051021	GDP-dissociation inhibitor binding(GO:0051021)
0.0	0.1	GO:0010484	H3 histone acetyltransferase activity(GO:0010484)
0.0	0.2	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.0	GO:0008948	oxaloacetate decarboxylase activity(GO:0008948)
0.0	0.2	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.0	0.2	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0	0.1	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0	0.1	GO:0008260	3-oxoacid CoA-transferase activity(GO:0008260)
0.0	0.2	GO:0048273	mitogen-activated protein kinase p38 binding(GO:0048273)
0.0	0.1	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.1	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.3	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.1	GO:0015181	arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0	0.2	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.5	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.2	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:2001069	glycogen binding(GO:2001069)
0.0	0.1	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.1	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0	0.5	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.1	GO:0016615	malate dehydrogenase activity(GO:0016615)
0.0	0.0	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.1	GO:0034950	mono-butyltin dioxygenase activity(GO:0018586) tri-n-butyltin dioxygenase activity(GO:0018588) di-n-butyltin dioxygenase activity(GO:0018589) methylsilanetriol hydroxylase activity(GO:0018590) methyl tertiary butyl ether 3-monooxygenase activity(GO:0018591) 4-nitrocatechol 4-monooxygenase activity(GO:0018592) 4-chlorophenoxyacetate monooxygenase activity(GO:0018593) tert-butanol 2-monooxygenase activity(GO:0018594) alpha-pinene monooxygenase activity(GO:0018595) dimethylsilanediol hydroxylase activity(GO:0018596) ammonia monooxygenase activity(GO:0018597) hydroxymethylsilanetriol oxidase activity(GO:0018598) 2-hydroxyisobutyrate 3-monooxygenase activity(GO:0018599) alpha-pinene dehydrogenase activity(GO:0018600) bisphenol A hydroxylase B activity(GO:0034559) 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity(GO:0034562) 9-fluorenone-3,4-dioxygenase activity(GO:0034786) anthracene 9,10-dioxygenase activity(GO:0034816) 2-(methylthio)benzothiazole monooxygenase activity(GO:0034857) 2-hydroxybenzothiazole monooxygenase activity(GO:0034858) benzothiazole monooxygenase activity(GO:0034859) 2,6-dihydroxybenzothiazole monooxygenase activity(GO:0034862) pinacolone 5-monooxygenase activity(GO:0034870) thioacetamide S-oxygenase activity(GO:0034873) thioacetamide S-oxide S-oxygenase activity(GO:0034874) endosulfan monooxygenase I activity(GO:0034888) N-nitrodimethylamine hydroxylase activity(GO:0034893) 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity(GO:0034897) endosulfan ether monooxygenase activity(GO:0034903) pyrene 4,5-monooxygenase activity(GO:0034925) pyrene 1,2-monooxygenase activity(GO:0034927) 1-hydroxypyrene 6,7-monooxygenase activity(GO:0034928) 1-hydroxypyrene 7,8-monooxygenase activity(GO:0034929) phenylboronic acid monooxygenase activity(GO:0034950) spheroidene monooxygenase activity(GO:0043823)
0.0	0.1	GO:1904288	BAT3 complex binding(GO:1904288)
0.0	0.1	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.3	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.2	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.1	GO:0045505	dynein intermediate chain binding(GO:0045505)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.4	GO:0030552	cAMP binding(GO:0030552)
0.0	0.1	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.2	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0	0.3	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0004396	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.0	0.0	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	0.1	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.0	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
0.0	0.2	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.0	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.0	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	0.0	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.0	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768)
0.0	0.1	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.0	0.1	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.3	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.0	0.0	GO:0031893	vasopressin receptor binding(GO:0031893)
0.0	0.0	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.0	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	0.0	GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.2	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.0	0.0	GO:0031711	bradykinin receptor binding(GO:0031711)
0.0	0.1	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.0	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0	0.0	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.1	GO:0009922	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.3	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.1	GO:0030553	cGMP binding(GO:0030553)
0.0	0.1	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.0	GO:0031781	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.1	GO:0017151	DEAD/H-box RNA helicase binding(GO:0017151)
0.0	0.0	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.2	GO:0008579	JUN kinase phosphatase activity(GO:0008579)
0.0	0.1	GO:0070990	snRNP binding(GO:0070990)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0005536	glucose binding(GO:0005536)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.6	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.4	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.8	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	PID IGF1 PATHWAY	IGF1 pathway
0.2	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	PID CD40 PATHWAY	CD40/CD40L signaling
0.1	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.3	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.3	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0	0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.2	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.0	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.2	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.2	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.2	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.4	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.2	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.1	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.0	0.1	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends

Results for Atf7_E4f1

Z-value: 0.77

Motif logo

Transcription factors associated with Atf7_E4f1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Atf7_E4f1 motif across conditions

Conditions sorted by the z-value of the Atf7_E4f1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf7_E4f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: