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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Batf

Z-value: 1.35

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Transcription factors associated with Batf

Gene Symbol	Gene ID	Gene Info
Batf Ensembl NCBI MGI UniProt	ENSMUSG00000034266.5	Batf

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Batf	chr12_85698292_85698454	9081	0.128209	-0.10	8.5e-01	Click!

Activity of the Batf motif across conditions

Conditions sorted by the z-value of the Batf motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr18_46997805_46997956	0.87	Gm22791	predicted gene, 22791	12399	0.15
chr18_46998104_46998255	0.66	Gm22791	predicted gene, 22791	12698	0.15
chr5_21384627_21384845	0.57	Fgl2	fibrinogen-like protein 2	12094	0.18
chr13_44306229_44306411	0.49	Gm29676	predicted gene, 29676	25871	0.17
chr6_142451928_142452079	0.47	Gys2	glycogen synthase 2	21106	0.15
chr7_132572852_132573003	0.44	Oat	ornithine aminotransferase	2791	0.22
chr6_117604955_117605122	0.43	Gm45083	predicted gene 45083	7532	0.22
chr15_59448754_59448952	0.40	Nsmce2	NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase	74566	0.09
chr4_141955631_141955810	0.39	Fhad1	forkhead-associated (FHA) phosphopeptide binding domain 1	1526	0.3
chr5_31036629_31036808	0.39	Slc5a6	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	1276	0.28
chr19_32601214_32601377	0.39	Papss2	3'-phosphoadenosine 5'-phosphosulfate synthase 2	5505	0.24
chr1_154077652_154077830	0.38	Gm25336	predicted gene, 25336	2458	0.27
chr10_98666150_98666367	0.36	Gm5427	predicted gene 5427	33452	0.22
chr13_54323551_54323702	0.36	Gm48622	predicted gene, 48622	4254	0.19
chr14_38629749_38629921	0.35	Gm20641	predicted gene 20641	107786	0.08
chr8_33950546_33950701	0.35	Rbpms	RNA binding protein gene with multiple splicing	20760	0.14
chr18_20157783_20157946	0.35	Dsc1	desmocollin 1	42993	0.17
chr9_65084518_65084694	0.35	Dpp8	dipeptidylpeptidase 8	8858	0.14
chr15_53163238_53163412	0.33	Ext1	exostosin glycosyltransferase 1	32930	0.25
chrX_60362413_60362564	0.33	Mir505	microRNA 505	32004	0.17
chr8_77128069_77128235	0.33	Nr3c2	nuclear receptor subfamily 3, group C, member 2	139	0.97
chr11_117914869_117915020	0.33	Gm11726	predicted gene 11726	6961	0.13
chr6_67441579_67441755	0.33	Gm44083	predicted gene, 44083	23616	0.11
chr18_34864196_34864456	0.33	Egr1	early growth response 1	3119	0.18
chr9_84977601_84977752	0.32	Gm8228	predicted gene 8228	1161	0.55
chr4_57312348_57312552	0.32	Ptpn3	protein tyrosine phosphatase, non-receptor type 3	10613	0.17
chr11_16737408_16737579	0.32	Gm25698	predicted gene, 25698	4782	0.22
chr16_8659432_8659599	0.31	Pmm2	phosphomannomutase 2	10923	0.1
chr11_16860515_16860728	0.31	Egfr	epidermal growth factor receptor	17529	0.19
chr7_26313878_26314034	0.30	Gm42375	predicted gene, 42375	6670	0.14
chr11_16703044_16703296	0.30	Gm25698	predicted gene, 25698	29541	0.15
chr3_18251077_18251277	0.30	Cyp7b1	cytochrome P450, family 7, subfamily b, polypeptide 1	7839	0.24
chr12_28699054_28699358	0.30	Trappc12	trafficking protein particle complex 12	2403	0.22
chr6_51709095_51709246	0.30	Gm38811	predicted gene, 38811	1911	0.43
chr19_40158328_40158479	0.29	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	28883	0.13
chr9_15297335_15297517	0.29	4931406C07Rik	RIKEN cDNA 4931406C07 gene	4088	0.06
chr17_70746763_70747075	0.29	5031415H12Rik	RIKEN cDNA 5031415H12 gene	8663	0.19
chr2_4542651_4542802	0.29	Frmd4a	FERM domain containing 4A	17028	0.2
chr4_105557523_105557702	0.29	Gm12726	predicted gene 12726	20728	0.24
chr15_7297709_7298002	0.29	Egflam	EGF-like, fibronectin type III and laminin G domains	43087	0.16
chr2_39161075_39161269	0.28	Gm16523	predicted gene, 16523	817	0.5
chr1_162987339_162987541	0.28	Fmo3	flavin containing monooxygenase 3	2912	0.22
chr2_42039219_42039481	0.28	Gm13461	predicted gene 13461	50521	0.18
chr3_109255070_109255263	0.28	Gm13865	predicted gene 13865	62299	0.11
chr15_43701477_43701832	0.28	Gm2140	predicted gene 2140	106807	0.07
chr6_55250906_55251062	0.27	Mindy4	MINDY lysine 48 deubiquitinase 4	27171	0.15
chr7_51868214_51868365	0.27	Gas2	growth arrest specific 2	4385	0.17
chr8_56443820_56444020	0.27	Gm7419	predicted gene 7419	9595	0.2
chr17_25756148_25756299	0.26	Msln	mesothelin	1845	0.11
chr14_57107820_57108112	0.25	Gjb2	gap junction protein, beta 2	3264	0.19
chr2_147988721_147988917	0.25	9030622O22Rik	RIKEN cDNA 9030622O22 gene	12634	0.21
chr1_182383191_182383342	0.25	Gm5706	predicted gene 5706	10269	0.15
chr18_39816253_39816404	0.25	Pabpc2	poly(A) binding protein, cytoplasmic 2	42831	0.17
chr11_60356089_60356253	0.25	Drc3	dynein regulatory complex subunit 3	2791	0.16
chr7_130968693_130968854	0.25	Htra1	HtrA serine peptidase 1	12897	0.19
chr6_122654614_122654765	0.25	Dppa3	developmental pluripotency-associated 3	27936	0.1
chr8_128648206_128648359	0.24	Gm26002	predicted gene, 26002	2715	0.24
chr13_75789506_75789657	0.24	Gm8288	predicted gene 8288	13125	0.13
chr1_71723871_71724224	0.24	Gm5256	predicted gene 5256	9123	0.19
chr8_75372121_75372290	0.24	Umpk-ps	uridine monophosphate kinase, pseudogene	11597	0.15
chr7_110953364_110953689	0.24	Mrvi1	MRV integration site 1	7339	0.2
chr11_4195737_4195910	0.24	Tbc1d10a	TBC1 domain family, member 10a	9001	0.1
chrX_74243813_74243964	0.24	Flna	filamin, alpha	2476	0.11
chr4_105149185_105149336	0.23	Plpp3	phospholipid phosphatase 3	8087	0.26
chr13_30036706_30036863	0.23	Gm11368	predicted gene 11368	21893	0.17
chr13_98317974_98318142	0.23	Gm9828	predicted gene 9828	648	0.51
chr9_56497408_56497559	0.23	Gm47175	predicted gene, 47175	9178	0.16
chr7_25411234_25411387	0.23	Cxcl17	chemokine (C-X-C motif) ligand 17	1576	0.21
chr1_71807937_71808302	0.22	Gm37217	predicted gene, 37217	38491	0.15
chr8_8947104_8947393	0.22	Gm44515	predicted gene 44515	14549	0.25
chr2_8116897_8117048	0.22	Gm13254	predicted gene 13254	30893	0.26
chr3_151298420_151298623	0.22	4930555A03Rik	RIKEN cDNA 4930555A03 gene	3518	0.3
chr15_53184591_53184792	0.22	Ext1	exostosin glycosyltransferase 1	11564	0.31
chr4_133680298_133680626	0.22	Pigv	phosphatidylinositol glycan anchor biosynthesis, class V	7815	0.13
chr11_31747063_31747263	0.22	Gm38061	predicted gene, 38061	48515	0.13
chr4_120978377_120978528	0.22	Smap2	small ArfGAP 2	2744	0.18
chr19_14736673_14736829	0.22	Gm26026	predicted gene, 26026	18271	0.26
chr4_49435274_49435479	0.22	Acnat1	acyl-coenzyme A amino acid N-acyltransferase 1	15758	0.12
chr2_120518757_120518908	0.22	Zfp106	zinc finger protein 106	1714	0.3
chr15_102014961_102015124	0.22	Krt8	keratin 8	10560	0.11
chr15_3644705_3644883	0.22	Gm22031	predicted gene, 22031	41397	0.17
chr7_75618027_75618186	0.22	Akap13	A kinase (PRKA) anchor protein 13	3418	0.26
chr6_142708472_142708687	0.22	Abcc9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	6264	0.22
chr7_4170342_4170493	0.22	Cdc42ep5	CDC42 effector protein (Rho GTPase binding) 5	5557	0.09
chr18_34927551_34927712	0.21	Etf1	eukaryotic translation termination factor 1	4376	0.14
chr17_34143075_34143349	0.21	H2-DMb2	histocompatibility 2, class II, locus Mb2	95	0.89
chr12_79600452_79600623	0.21	Rad51b	RAD51 paralog B	273184	0.01
chr8_116344914_116345106	0.21	1700018P08Rik	RIKEN cDNA 1700018P08 gene	12051	0.29
chr10_109182870_109183021	0.21	Gm44495	predicted gene, 44495	143906	0.04
chr7_92640507_92640658	0.21	6430511E19Rik	RIKEN cDNA 6430511E19 gene	633	0.44
chr9_107654301_107654478	0.21	Slc38a3	solute carrier family 38, member 3	1631	0.17
chr9_116136919_116137123	0.21	Tgfbr2	transforming growth factor, beta receptor II	38244	0.15
chr10_127544019_127544184	0.21	Lrp1	low density lipoprotein receptor-related protein 1	893	0.41
chrX_129698555_129698713	0.21	Diaph2	diaphanous related formin 2	51108	0.17
chr1_60833760_60833934	0.21	Gm11581	predicted gene 11581	24731	0.11
chr7_98580551_98580702	0.21	Emsy	EMSY, BRCA2-interacting transcriptional repressor	13609	0.15
chr14_71251214_71251453	0.21	Gm4251	predicted gene 4251	49	0.99
chr2_167293432_167293597	0.21	Gm11473	predicted gene 11473	11737	0.16
chr7_79308613_79308815	0.21	Gm39041	predicted gene, 39041	9689	0.14
chr15_77412067_77412222	0.21	Apol9a	apolipoprotein L 9a	1009	0.35
chr19_6390399_6390550	0.21	Pygm	muscle glycogen phosphorylase	2237	0.14
chr17_34593277_34593428	0.21	Pbx2	pre B cell leukemia homeobox 2	43	0.91
chr5_51876051_51876244	0.20	Gm42616	predicted gene 42616	3455	0.22
chr10_33814374_33814533	0.20	Gm10327	predicted pseudogene 10327	4955	0.17
chr4_9657208_9657376	0.20	Asph	aspartate-beta-hydroxylase	11794	0.19
chr14_86301775_86301947	0.20	Gm32815	predicted gene, 32815	2127	0.23
chr14_51106687_51106910	0.20	Eddm3b	epididymal protein 3B	7628	0.08
chr10_87936931_87937082	0.20	Tyms-ps	thymidylate synthase, pseudogene	29841	0.15
chrX_169863890_169864041	0.20	Mid1	midline 1	15657	0.24
chr12_62877016_62877197	0.20	Gm7763	predicted gene 7763	6176	0.25
chr12_25784515_25784666	0.20	Gm9321	predicted gene 9321	35951	0.2
chr11_16904746_16904937	0.20	Egfr	epidermal growth factor receptor	344	0.88
chr8_40651238_40651389	0.20	Mtmr7	myotubularin related protein 7	16516	0.14
chr15_67780972_67781123	0.20	Gm49408	predicted gene, 49408	92781	0.09
chr3_95267928_95268183	0.20	Prune1	prune exopolyphosphatase	889	0.34
chr9_74366017_74366190	0.20	Nr1h2-ps	nuclear receptor subfamily 1, group H, member 2, pseudogene	1040	0.56
chr3_132565872_132566040	0.20	Gm25307	predicted gene, 25307	28291	0.18
chr7_49396252_49396429	0.20	Nav2	neuron navigator 2	31619	0.18
chr18_38780310_38780655	0.20	Gm8302	predicted gene 8302	8135	0.2
chrX_142490315_142490613	0.20	Gm25915	predicted gene, 25915	5017	0.21
chr2_8124945_8125169	0.20	Gm13254	predicted gene 13254	22808	0.29
chr2_115093304_115093458	0.20	Gm28493	predicted gene 28493	42169	0.17
chr5_45495684_45495835	0.20	Lap3	leucine aminopeptidase 3	2233	0.21
chr16_52701782_52701933	0.20	4930404A05Rik	RIKEN cDNA 4930404A05 gene	113887	0.06
chr10_24227101_24227252	0.20	Moxd1	monooxygenase, DBH-like 1	3631	0.24
chr6_29474717_29474868	0.20	Atp6v1fnb	Atp6v1f neighbor	3355	0.13
chr10_52273135_52273286	0.20	Dcbld1	discoidin, CUB and LCCL domain containing 1	39573	0.11
chr1_86633273_86633493	0.20	Gm22955	predicted gene, 22955	4225	0.14
chr14_70331481_70331660	0.20	Slc39a14	solute carrier family 39 (zinc transporter), member 14	52	0.96
chr17_86150939_86151254	0.19	Srbd1	S1 RNA binding domain 1	5921	0.21
chr7_105592397_105592767	0.19	Hpx	hemopexin	7530	0.09
chr1_93030160_93030324	0.19	Kif1a	kinesin family member 1A	3037	0.18
chr15_35268847_35269014	0.19	Osr2	odd-skipped related 2	27168	0.17
chr10_56598323_56598474	0.19	Gm9795	predicted pseudogene 9795	57796	0.14
chr7_92640281_92640449	0.19	6430511E19Rik	RIKEN cDNA 6430511E19 gene	416	0.55
chr9_15653065_15653239	0.19	Gm7642	predicted gene 7642	8869	0.15
chr10_41893722_41893893	0.19	Sesn1	sestrin 1	4566	0.25
chr11_69663925_69664238	0.19	Mir1934	microRNA 1934	1038	0.16
chr11_121085268_121085439	0.19	Sectm1a	secreted and transmembrane 1A	4133	0.1
chr19_7456855_7457030	0.19	Rtn3	reticulon 3	26260	0.1
chr8_9501766_9501947	0.19	4930435N07Rik	RIKEN cDNA 4930435N07 gene	42764	0.13
chr14_9608900_9609103	0.19	Gm48371	predicted gene, 48371	139446	0.05
chr4_62629625_62629794	0.19	Gm11209	predicted gene 11209	4003	0.2
chr5_143056564_143056750	0.19	Gm43378	predicted gene 43378	6614	0.15
chr9_118101918_118102083	0.19	Azi2	5-azacytidine induced gene 2	42944	0.13
chr3_72659248_72659399	0.19	Gm37901	predicted gene, 37901	54975	0.16
chr3_129617903_129618076	0.19	Egf	epidermal growth factor	63557	0.08
chr19_10690326_10690666	0.19	Vps37c	vacuolar protein sorting 37C	1731	0.21
chr1_55529058_55529209	0.19	Gm37382	predicted gene, 37382	30327	0.18
chr13_64349576_64349754	0.18	Gm47123	predicted gene, 47123	11387	0.1
chr5_54060085_54060253	0.18	Stim2	stromal interaction molecule 2	14568	0.23
chr3_116189519_116189691	0.18	Gm31651	predicted gene, 31651	10803	0.15
chr18_12466149_12466310	0.18	Gm29199	predicted gene 29199	33233	0.13
chr16_30525931_30526082	0.18	Tmem44	transmembrane protein 44	14903	0.19
chr3_57504904_57505080	0.18	Gm16016	predicted gene 16016	23240	0.17
chr12_105019429_105019596	0.18	Gm47648	predicted gene, 47648	1847	0.2
chr3_135931021_135931195	0.18	Gm31243	predicted gene, 31243	2876	0.22
chr13_107600592_107600794	0.18	Gm32090	predicted gene, 32090	12156	0.22
chr6_91488990_91489149	0.18	Tmem43	transmembrane protein 43	12469	0.1
chr1_100496636_100496787	0.18	Gm18700	predicted gene, 18700	100364	0.08
chr11_16830427_16830830	0.18	Egfros	epidermal growth factor receptor, opposite strand	74	0.98
chr1_172903470_172903651	0.18	Apcs	serum amyloid P-component	8519	0.16
chr7_16639158_16639452	0.18	Gm29725	predicted gene, 29725	8484	0.09
chr6_35273676_35273858	0.18	Slc13a4	solute carrier family 13 (sodium/sulfate symporters), member 4	14407	0.14
chr5_90424369_90424630	0.18	Gm43363	predicted gene 43363	27226	0.13
chr16_22358863_22359092	0.18	Etv5	ets variant 5	42852	0.11
chr14_63899614_63899769	0.18	Pinx1	PIN2/TERF1 interacting, telomerase inhibitor 1	78	0.98
chr8_104110853_104111054	0.18	Cdh5	cadherin 5	354	0.82
chr16_43335246_43335402	0.18	Gm15711	predicted gene 15711	22730	0.14
chr1_115990300_115990467	0.18	Cntnap5a	contactin associated protein-like 5A	305627	0.01
chr11_16819865_16820197	0.18	Egfros	epidermal growth factor receptor, opposite strand	10671	0.22
chr4_102513252_102513556	0.17	Pde4b	phosphodiesterase 4B, cAMP specific	43007	0.2
chr12_102748209_102748378	0.17	Tmem251	transmembrane protein 251	4531	0.09
chr11_103262520_103262746	0.17	Map3k14	mitogen-activated protein kinase kinase kinase 14	4839	0.14
chr1_35759768_35759937	0.17	Gm25634	predicted gene, 25634	1750	0.42
chr15_4561546_4561984	0.17	C6	complement component 6	165410	0.03
chr2_21245334_21245495	0.17	Gm13378	predicted gene 13378	1309	0.45
chr11_118265609_118265912	0.17	Usp36	ubiquitin specific peptidase 36	288	0.89
chr4_101742085_101742265	0.17	Lepr	leptin receptor	24768	0.19
chr7_46755251_46755407	0.17	Saa2	serum amyloid A 2	3458	0.11
chr15_3743269_3743441	0.17	Gm4823	predicted gene 4823	3520	0.34
chr16_45365461_45365847	0.17	Cd200	CD200 antigen	34658	0.14
chr13_51833684_51833946	0.17	Gadd45g	growth arrest and DNA-damage-inducible 45 gamma	12863	0.21
chr2_59670423_59670592	0.17	Tanc1	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	23696	0.24
chr19_37213872_37214035	0.17	Marchf5	membrane associated ring-CH-type finger 5	3237	0.17
chr17_15701795_15701946	0.17	Chd1	chromodomain helicase DNA binding protein 1	3097	0.26
chr12_83927956_83928132	0.17	Numb	NUMB endocytic adaptor protein	6110	0.12
chr4_135989135_135989286	0.17	Pithd1	PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1	1946	0.16
chr5_53196740_53196918	0.17	Sel1l3	sel-1 suppressor of lin-12-like 3 (C. elegans)	16486	0.19
chr5_128579419_128579592	0.17	Fzd10os	frizzled class receptor 10, opposite strand	5873	0.17
chr18_64079634_64079810	0.17	Gm6974	predicted gene 6974	1698	0.42
chr18_6501445_6501680	0.17	Epc1	enhancer of polycomb homolog 1	10706	0.16
chr8_126591993_126592171	0.17	Irf2bp2	interferon regulatory factor 2 binding protein 2	1904	0.39
chr2_120170818_120170979	0.17	Ehd4	EH-domain containing 4	16292	0.15
chr15_75007426_75007737	0.17	Gm28068	predicted gene 28068	278	0.8
chr2_6333653_6333804	0.17	AL845275.1	novel protein	10648	0.19
chr13_54988316_54988535	0.17	Unc5a	unc-5 netrin receptor A	8114	0.16
chr12_104175756_104175908	0.17	Serpina3d-ps	serine (or cysteine) peptidase inhibitor, clade A, member 3D, pseudogene	2464	0.15
chr8_86807888_86808046	0.17	N4bp1	NEDD4 binding protein 1	36078	0.13
chr7_71289589_71289818	0.17	Gm29328	predicted gene 29328	25428	0.16

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Batf

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.2	GO:1902488	cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.1	0.2	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1	0.2	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.0	0.1	GO:2000587	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.2	GO:0021943	formation of radial glial scaffolds(GO:0021943)
0.0	0.1	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	0.1	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.3	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.0	0.1	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.1	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.1	GO:1901552	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.0	0.1	GO:0051025	negative regulation of immunoglobulin secretion(GO:0051025)
0.0	0.1	GO:0006549	isoleucine metabolic process(GO:0006549)
0.0	0.1	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:1904017	response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0	0.1	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.1	GO:0003419	growth plate cartilage chondrocyte proliferation(GO:0003419)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.1	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0034184	positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0	0.1	GO:0098902	regulation of membrane depolarization during action potential(GO:0098902)
0.0	0.1	GO:0045917	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.0	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.0	GO:2000152	regulation of ubiquitin-specific protease activity(GO:2000152)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.0	GO:0060557	positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.0	0.1	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.4	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.1	GO:0044004	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0	0.1	GO:0014016	neuroblast differentiation(GO:0014016)
0.0	0.1	GO:0015755	fructose transport(GO:0015755)
0.0	0.1	GO:0070995	NADPH oxidation(GO:0070995)
0.0	0.1	GO:0071276	cellular response to cadmium ion(GO:0071276)
0.0	0.1	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.0	0.0	GO:0009233	menaquinone metabolic process(GO:0009233)
0.0	0.1	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0	0.1	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.2	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.1	GO:0097503	sialylation(GO:0097503)
0.0	0.1	GO:0072300	positive regulation of metanephric glomerulus development(GO:0072300)
0.0	0.1	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0	0.1	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.0	GO:0072718	response to cisplatin(GO:0072718)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.1	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.1	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.1	GO:1902916	positive regulation of protein polyubiquitination(GO:1902916)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.0	GO:1904479	negative regulation of intestinal absorption(GO:1904479)
0.0	0.0	GO:0035771	interleukin-4-mediated signaling pathway(GO:0035771)
0.0	0.1	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.0	0.1	GO:0006069	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.0	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.0	0.1	GO:0010693	negative regulation of alkaline phosphatase activity(GO:0010693)
0.0	0.1	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0	0.0	GO:0070949	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.0	0.1	GO:0060613	fat pad development(GO:0060613)
0.0	0.1	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.0	GO:0061010	gall bladder development(GO:0061010)
0.0	0.0	GO:0090259	regulation of retinal ganglion cell axon guidance(GO:0090259)
0.0	0.0	GO:0003330	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0	0.1	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0051365	cellular response to potassium ion starvation(GO:0051365)
0.0	0.0	GO:1904058	positive regulation of sensory perception of pain(GO:1904058)
0.0	0.0	GO:0010159	specification of organ position(GO:0010159)
0.0	0.1	GO:0071397	cellular response to cholesterol(GO:0071397)
0.0	0.1	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.0	0.0	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.0	0.1	GO:0051084	'de novo' protein folding(GO:0006458) 'de novo' posttranslational protein folding(GO:0051084)
0.0	0.0	GO:0060687	regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0	0.0	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.0	0.0	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.0	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.0	0.0	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.0	GO:0006172	ADP biosynthetic process(GO:0006172)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0032304	negative regulation of icosanoid secretion(GO:0032304)
0.0	0.1	GO:0009109	coenzyme catabolic process(GO:0009109)
0.0	0.0	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0	0.1	GO:0098908	regulation of neuronal action potential(GO:0098908)
0.0	0.0	GO:0060318	definitive erythrocyte differentiation(GO:0060318)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.1	GO:0033625	positive regulation of integrin activation(GO:0033625)
0.0	0.0	GO:0000957	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.0	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.0	GO:1903689	regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.0	0.0	GO:0042525	tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525)
0.0	0.0	GO:1903911	positive regulation of receptor clustering(GO:1903911) regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0	0.0	GO:0030222	eosinophil differentiation(GO:0030222)
0.0	0.0	GO:2000304	positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0	0.0	GO:1903275	positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.0	0.0	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0	0.0	GO:0014717	regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.0	0.0	GO:0060468	prevention of polyspermy(GO:0060468)
0.0	0.0	GO:0070432	regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.0	0.0	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.0	0.1	GO:0072307	metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0007343	egg activation(GO:0007343)
0.0	0.0	GO:2000169	regulation of peptidyl-cysteine S-nitrosylation(GO:2000169)
0.0	0.0	GO:0006566	threonine metabolic process(GO:0006566)
0.0	0.0	GO:0042117	monocyte activation(GO:0042117)
0.0	0.0	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
0.0	0.0	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0	0.1	GO:0034398	telomere tethering at nuclear periphery(GO:0034398)
0.0	0.0	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.0	GO:0060527	prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0	0.0	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.0	GO:0038109	response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0	0.1	GO:0034551	respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0	0.0	GO:0045990	carbon catabolite regulation of transcription(GO:0045990)
0.0	0.1	GO:0043031	negative regulation of macrophage activation(GO:0043031)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.3	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:0097451	glial limiting end-foot(GO:0097451)
0.0	0.2	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.2	GO:0002139	stereocilia coupling link(GO:0002139)
0.0	0.1	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0	0.1	GO:0020018	ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.1	GO:0005785	signal recognition particle receptor complex(GO:0005785)
0.0	0.1	GO:0044614	nuclear pore cytoplasmic filaments(GO:0044614)
0.0	0.1	GO:0097648	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.1	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0030915	Smc5-Smc6 complex(GO:0030915)
0.0	0.0	GO:0034457	Mpp10 complex(GO:0034457)
0.0	0.1	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0	0.1	GO:0005955	calcineurin complex(GO:0005955)
0.0	0.1	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0000120	RNA polymerase I transcription factor complex(GO:0000120)
0.0	0.0	GO:0044611	nuclear pore inner ring(GO:0044611)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.0	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.0	0.2	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.0	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.2	GO:0005922	connexon complex(GO:0005922)
0.0	0.0	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.0	0.0	GO:0097443	sorting endosome(GO:0097443)
0.0	0.0	GO:0031523	Myb complex(GO:0031523)
0.0	0.0	GO:0032437	cuticular plate(GO:0032437)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.2	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.3	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.0	0.1	GO:0015315	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.2	GO:0070728	leucine binding(GO:0070728)
0.0	0.1	GO:0001030	RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084)
0.0	0.2	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0010858	calcium-dependent protein kinase regulator activity(GO:0010858)
0.0	0.2	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.0	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.1	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.2	GO:0010521	telomerase inhibitor activity(GO:0010521)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0035276	ethanol binding(GO:0035276)
0.0	0.1	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.1	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.2	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.1	GO:0015182	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.0	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.0	GO:0030519	snoRNP binding(GO:0030519)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.0	GO:0034040	lipid-transporting ATPase activity(GO:0034040)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.2	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.2	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	0.0	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0	0.0	GO:0032551	UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551)
0.0	0.1	GO:0070061	fructose binding(GO:0070061)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.0	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.0	0.0	GO:0045134	uridine-diphosphatase activity(GO:0045134)
0.0	0.0	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.1	GO:0036122	BMP binding(GO:0036122)
0.0	0.1	GO:0004779	sulfate adenylyltransferase activity(GO:0004779)
0.0	0.2	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.0	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.0	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.1	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.0	GO:0004471	malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471)
0.0	0.0	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.0	GO:0033142	progesterone receptor binding(GO:0033142)
0.0	0.0	GO:0004487	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0	0.0	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0	0.0	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.0	0.0	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.0	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.0	GO:0016838	carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0	0.1	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0	0.0	GO:0043199	sulfate binding(GO:0043199)
0.0	0.1	GO:0070567	cytidylyltransferase activity(GO:0070567)
0.0	0.1	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.0	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.0	0.0	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.3	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0	0.1	GO:0016868	intramolecular transferase activity, phosphotransferases(GO:0016868)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.0	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	0.0	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.0	0.3	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.0	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.0	REACTOME G1 S TRANSITION	Genes involved in G1/S Transition
0.0	0.1	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.2	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.1	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway