Project

ENCSR904DTN: DNase-seq of mouse liver in constant darkness

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Cbfb

Z-value: 0.56

Motif logo

Transcription factors associated with Cbfb

Gene Symbol	Gene ID	Gene Info
Cbfb Ensembl NCBI MGI UniProt	ENSMUSG00000031885.7	Cbfb

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Cbfb	chr8_105171632_105171820	162	0.843457	-0.67	1.5e-01	Click!
Cbfb	chr8_105170139_105170326	442	0.664693	-0.61	2.0e-01	Click!
Cbfb	chr8_105171853_105172004	364	0.565879	-0.57	2.4e-01	Click!
Cbfb	chr8_105170450_105170615	142	0.904822	0.45	3.7e-01	Click!
Cbfb	chr8_105169758_105169909	841	0.401169	-0.16	7.6e-01	Click!

Activity of the Cbfb motif across conditions

Conditions sorted by the z-value of the Cbfb motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_59893097_59893271	0.20	Gm19866	predicted gene, 19866	13935	0.13
chr6_112939448_112939605	0.20	Srgap3	SLIT-ROBO Rho GTPase activating protein 3	7228	0.15
chr1_45826928_45827079	0.19	Wdr75	WD repeat domain 75	4445	0.16
chr5_66114850_66115151	0.19	Rbm47	RNA binding motif protein 47	16809	0.11
chr11_80453320_80453471	0.18	Psmd11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	2973	0.25
chr6_55138486_55138637	0.17	Crhr2	corticotropin releasing hormone receptor 2	5545	0.18
chr8_111739071_111739223	0.17	Bcar1	breast cancer anti-estrogen resistance 1	4662	0.21
chr7_115686790_115686973	0.16	Sox6	SRY (sex determining region Y)-box 6	24516	0.27
chr8_77045181_77045332	0.15	Nr3c2	nuclear receptor subfamily 3, group C, member 2	82757	0.09
chr6_127265923_127266082	0.15	Gm43635	predicted gene 43635	11358	0.12
chr11_4984826_4985069	0.14	Ap1b1	adaptor protein complex AP-1, beta 1 subunit	1877	0.26
chr9_40777068_40777228	0.14	Clmp	CXADR-like membrane protein	3054	0.12
chr17_42900854_42901005	0.14	Cd2ap	CD2-associated protein	24264	0.24
chr5_114378364_114378515	0.13	Kctd10	potassium channel tetramerisation domain containing 10	2044	0.21
chr1_184605964_184606231	0.12	Rpl21-ps1	ribosomal protein 21, pseudogene 1	11151	0.15
chr9_94993733_94993884	0.12	Gm47168	predicted gene, 47168	1124	0.65
chr5_144126093_144126244	0.12	Gm26925	predicted gene, 26925	14396	0.14
chr2_68884019_68884170	0.12	Gm37159	predicted gene, 37159	7272	0.15
chr6_128646065_128646273	0.12	Gm5884	predicted pseudogene 5884	1256	0.23
chr16_31419378_31420071	0.12	Bdh1	3-hydroxybutyrate dehydrogenase, type 1	2556	0.19
chr1_119173195_119173378	0.12	Gm8321	predicted gene 8321	15700	0.22
chr4_149282398_149282549	0.11	Kif1b	kinesin family member 1B	25033	0.13
chr10_5592140_5592291	0.11	Myct1	myc target 1	1560	0.45
chr12_105686564_105686722	0.11	Gskip	GSK3B interacting protein	1242	0.32
chr1_74400693_74400993	0.11	Mir26b	microRNA 26b	6533	0.11
chr18_39251064_39251253	0.11	Arhgap26	Rho GTPase activating protein 26	23790	0.21
chr2_75611169_75611330	0.11	Gm13655	predicted gene 13655	22133	0.15
chr7_122665413_122665987	0.11	Cacng3	calcium channel, voltage-dependent, gamma subunit 3	4792	0.21
chr1_138967552_138967703	0.11	Dennd1b	DENN/MADD domain containing 1B	93	0.91
chr6_141866172_141866335	0.10	Gm30784	predicted gene, 30784	105	0.97
chr19_26748788_26748982	0.10	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	353	0.9
chr1_31019080_31019348	0.10	4931428L18Rik	RIKEN cDNA 4931428L18 gene	19310	0.13
chr11_75459071_75459222	0.10	Mir22hg	Mir22 host gene (non-protein coding)	2393	0.12
chr13_64313921_64314144	0.10	Prxl2c	peroxiredoxin like 2C	1322	0.27
chr10_67185588_67186325	0.10	Jmjd1c	jumonji domain containing 1C	203	0.95
chr2_104817028_104817755	0.10	Qser1	glutamine and serine rich 1	631	0.64
chr6_128503302_128503638	0.10	Pzp	PZP, alpha-2-macroglobulin like	8247	0.09
chr3_57431826_57431986	0.10	Tm4sf4	transmembrane 4 superfamily member 4	6592	0.23
chr15_27528988_27529148	0.10	B230362B09Rik	RIKEN cDNA B230362B09 gene	25156	0.14
chr9_116847373_116847540	0.10	Rbms3	RNA binding motif, single stranded interacting protein	24637	0.27
chr2_168314984_168315140	0.10	Gm14262	predicted gene 14262	19941	0.13
chr4_118033071_118033392	0.10	St3gal3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	1349	0.44
chr9_110362456_110362638	0.10	Scap	SREBF chaperone	930	0.43
chr3_107223260_107223437	0.10	Cym	chymosin	1616	0.29
chr11_38681374_38681545	0.10	Gm23520	predicted gene, 23520	116818	0.07
chr12_100528331_100528561	0.10	Ttc7b	tetratricopeptide repeat domain 7B	7620	0.17
chr10_59901049_59901200	0.10	Dnajb12	DnaJ heat shock protein family (Hsp40) member B12	21498	0.14
chr19_39284209_39284379	0.10	Cyp2c29	cytochrome P450, family 2, subfamily c, polypeptide 29	2780	0.3
chr19_34819627_34820189	0.10	Mir107	microRNA 107	865	0.51
chr7_81326206_81326373	0.10	Rps17	ribosomal protein S17	18242	0.14
chr13_95894500_95894710	0.10	Iqgap2	IQ motif containing GTPase activating protein 2	2122	0.3
chr14_66199873_66200054	0.09	Ptk2b	PTK2 protein tyrosine kinase 2 beta	13589	0.19
chr12_110757292_110757448	0.09	Wdr20	WD repeat domain 20	19161	0.13
chr19_31896057_31896235	0.09	Gm19241	predicted gene, 19241	17498	0.2
chr4_83167479_83167646	0.09	Gm11185	predicted gene 11185	26426	0.17
chr11_61389045_61389196	0.09	Slc47a1	solute carrier family 47, member 1	10775	0.13
chr17_80921778_80921949	0.09	Gm9386	predicted pseudogene 9386	16851	0.18
chr2_12011493_12011801	0.09	Gm13310	predicted gene 13310	72345	0.1
chr8_31980849_31981024	0.09	Nrg1	neuregulin 1	28170	0.23
chr1_193102685_193102845	0.09	Utp25	UTP25 small subunit processome component	11910	0.14
chr18_54921904_54922070	0.09	Zfp608	zinc finger protein 608	26425	0.17
chr1_118458813_118459291	0.09	Gm22710	predicted gene, 22710	213	0.44
chr3_96528686_96528855	0.09	Hjv	hemojuvelin BMP co-receptor	3598	0.09
chr10_125317485_125317647	0.09	Gm45604	predicted gene 45604	8654	0.23
chr8_115761720_115761892	0.09	Maf	avian musculoaponeurotic fibrosarcoma oncogene homolog	54012	0.15
chr3_132565872_132566040	0.09	Gm25307	predicted gene, 25307	28291	0.18
chr1_106309746_106309897	0.09	Phlpp1	PH domain and leucine rich repeat protein phosphatase 1	7417	0.25
chr4_57916402_57916601	0.09	D630039A03Rik	RIKEN cDNA D630039A03 gene	204	0.94
chr16_4405370_4405807	0.09	Adcy9	adenylate cyclase 9	13999	0.21
chr4_105104623_105104776	0.09	Prkaa2	protein kinase, AMP-activated, alpha 2 catalytic subunit	5191	0.29
chr1_140183261_140183634	0.09	Cfh	complement component factor h	36	0.98
chr6_38866474_38866676	0.09	Tbxas1	thromboxane A synthase 1, platelet	8829	0.21
chr4_41493635_41493797	0.09	Myorg	myogenesis regulating glycosidase (putative)	8952	0.1
chr1_93723491_93723642	0.09	Gm10550	predicted gene 10550	7538	0.13
chr15_82671625_82671923	0.09	Cyp2d36-ps	cytochrome P450, family 2, subfamily d, polypeptide 36, pseudogene	11483	0.08
chr11_32688599_32688774	0.09	Fbxw11	F-box and WD-40 domain protein 11	45782	0.14
chr6_15728953_15729104	0.09	Mdfic	MyoD family inhibitor domain containing	1229	0.59
chr9_102410773_102410941	0.09	Gm22894	predicted gene, 22894	37739	0.13
chr13_104650268_104650432	0.09	2610204G07Rik	RIKEN cDNA 2610204G07 gene	34581	0.22
chr18_63463560_63463749	0.09	Gm23581	predicted gene, 23581	44515	0.11
chr1_127269428_127269591	0.08	Gm37510	predicted gene, 37510	1015	0.5
chr4_139208375_139208554	0.08	Capzb	capping protein (actin filament) muscle Z-line, beta	9197	0.15
chr19_23024753_23025259	0.08	Gm50136	predicted gene, 50136	36448	0.17
chr15_79741187_79741771	0.08	Sun2	Sad1 and UNC84 domain containing 2	613	0.45
chr12_25190485_25190636	0.08	Gm47705	predicted gene, 47705	8792	0.19
chr19_29180439_29180590	0.08	Gm5518	predicted gene 5518	20396	0.15
chr16_74514689_74514840	0.08	Gm49671	predicted gene, 49671	91498	0.08
chr6_86189199_86189379	0.08	Tgfa	transforming growth factor alpha	5934	0.17
chr4_115497333_115497797	0.08	Cyp4a14	cytochrome P450, family 4, subfamily a, polypeptide 14	1423	0.29
chr15_59721710_59721861	0.08	Gm20150	predicted gene, 20150	49672	0.14
chr8_48690628_48690947	0.08	Tenm3	teneurin transmembrane protein 3	16097	0.26
chr11_87984674_87984835	0.08	Dynll2	dynein light chain LC8-type 2	742	0.57
chr17_13402789_13403038	0.08	Gm8597	predicted gene 8597	1278	0.29
chr13_44293994_44294145	0.08	Gm29676	predicted gene, 29676	13620	0.2
chr10_69930149_69930514	0.08	Ank3	ankyrin 3, epithelial	4198	0.35
chr1_167247272_167247459	0.08	Uck2	uridine-cytidine kinase 2	4207	0.15
chr10_80914031_80914448	0.08	Lmnb2	lamin B2	3612	0.11
chr14_48714246_48714540	0.08	Gm49153	predicted gene, 49153	10209	0.1
chr8_128481354_128481549	0.08	Nrp1	neuropilin 1	122054	0.05
chr18_38631612_38631778	0.08	9630014M24Rik	RIKEN cDNA 9630014M24 gene	4408	0.19
chr6_113721227_113721413	0.08	Ghrl	ghrelin	1440	0.19
chr5_38480616_38480794	0.08	Slc2a9	solute carrier family 2 (facilitated glucose transporter), member 9	399	0.85
chr2_163411853_163412159	0.08	Oser1	oxidative stress responsive serine rich 1	341	0.82
chr11_97920651_97920808	0.08	Gm22461	predicted gene, 22461	21011	0.1
chr9_90260660_90260839	0.08	Tbc1d2b	TBC1 domain family, member 2B	4822	0.19
chr3_108134800_108134966	0.08	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3	11263	0.09
chr2_12905587_12905857	0.08	Pter	phosphotriesterase related	18319	0.22
chr12_79642030_79642203	0.08	9430078K24Rik	RIKEN cDNA 9430078K24 gene	282617	0.01
chr5_137628625_137628972	0.08	Fbxo24	F-box protein 24	158	0.55
chr4_86664611_86664778	0.08	Plin2	perilipin 2	1031	0.52
chr17_86203109_86203281	0.08	AC154542.1	TEC	27620	0.18
chr3_65533694_65533867	0.08	4931440P22Rik	RIKEN cDNA 4931440P22 gene	4401	0.15
chr4_117981622_117981822	0.08	9530034E10Rik	RIKEN cDNA 9530034E10 gene	6686	0.15
chr8_113202539_113202735	0.07	Gm10280	predicted gene 10280	135375	0.05
chr10_118797429_118797609	0.07	Gm4065	predicted gene 4065	7740	0.17
chr5_91274508_91274681	0.07	Gm19619	predicted gene, 19619	8827	0.24
chr9_31020201_31020366	0.07	Gm29724	predicted gene, 29724	10220	0.17
chr2_14130166_14130332	0.07	Stam	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	595	0.69
chr11_84476404_84476555	0.07	Aatf	apoptosis antagonizing transcription factor	15071	0.21
chr13_97239621_97239811	0.07	Enc1	ectodermal-neural cortex 1	1389	0.38
chr17_33563776_33563966	0.07	Myo1f	myosin IF	8106	0.14
chr2_65441659_65441885	0.07	Scn3a	sodium channel, voltage-gated, type III, alpha	53459	0.11
chr3_95894699_95894897	0.07	Aph1a	aph1 homolog A, gamma secretase subunit	333	0.72
chr8_83738255_83738433	0.07	Adgre5	adhesion G protein-coupled receptor E5	2825	0.16
chr1_136608978_136609129	0.07	4933409D19Rik	RIKEN cDNA 4933409D19 gene	3585	0.16
chr14_54433612_54433789	0.07	Mmp14	matrix metallopeptidase 14 (membrane-inserted)	1264	0.24
chr5_43904829_43905012	0.07	Gm16015	predicted gene 16015	4965	0.11
chr13_100849368_100849536	0.07	Gm29502	predicted gene 29502	2019	0.24
chr11_95461001_95461320	0.07	Gm11522	predicted gene 11522	1561	0.33
chr12_70280483_70280649	0.07	Trim9	tripartite motif-containing 9	12518	0.16
chr5_134974335_134974526	0.07	Cldn3	claudin 3	11784	0.07
chr11_90371567_90371726	0.07	Hlf	hepatic leukemia factor	10289	0.26
chr19_55660221_55660414	0.07	Tcf7l2	transcription factor 7 like 2, T cell specific, HMG box	81503	0.11
chr7_97211249_97211431	0.07	Usp35	ubiquitin specific peptidase 35	103685	0.06
chr11_55471153_55471304	0.07	G3bp1	GTPase activating protein (SH3 domain) binding protein 1	1510	0.25
chr18_74741418_74741569	0.07	Myo5b	myosin VB	7728	0.18
chr5_148936597_148936854	0.07	Katnal1	katanin p60 subunit A-like 1	7405	0.1
chr14_61294825_61294981	0.07	Gm19097	predicted gene, 19097	10115	0.12
chr12_111435070_111435221	0.07	Gm10425	predicted gene 10425	4199	0.14
chr2_122237988_122238172	0.07	Sord	sorbitol dehydrogenase	3331	0.14
chr18_20552765_20552968	0.07	Tpi-rs10	triosephosphate isomerase related sequence 10	3502	0.21
chr3_60516106_60516484	0.07	Mbnl1	muscleblind like splicing factor 1	11833	0.22
chr9_70827748_70828187	0.07	Gm3436	predicted pseudogene 3436	24609	0.16
chr19_31896808_31896966	0.07	Gm19241	predicted gene, 19241	16757	0.2
chr12_75668168_75668511	0.07	Wdr89	WD repeat domain 89	1188	0.51
chr18_31884190_31884397	0.07	Wdr33	WD repeat domain 33	2151	0.25
chr18_34864822_34864973	0.07	Egr1	early growth response 1	3690	0.17
chr4_155123910_155124068	0.07	Morn1	MORN repeat containing 1	13299	0.15
chr7_27474827_27474987	0.07	Sertad3	SERTA domain containing 3	1139	0.28
chr10_108619351_108620201	0.07	Syt1	synaptotagmin I	17188	0.25
chr2_26543305_26543481	0.07	Gm13358	predicted gene 13358	15232	0.09
chr8_108887457_108887635	0.07	Gm38318	predicted gene, 38318	19984	0.2
chr19_43949859_43950010	0.07	Dnmbp	dynamin binding protein	9743	0.13
chr19_29667197_29667356	0.07	Ermp1	endoplasmic reticulum metallopeptidase 1	18861	0.17
chr5_121659952_121660313	0.07	Acad10	acyl-Coenzyme A dehydrogenase family, member 10	347	0.52
chr18_80275077_80275246	0.07	Slc66a2	solute carrier family 66 member 2	12321	0.11
chr9_42998416_42998567	0.07	Arhgef12	Rho guanine nucleotide exchange factor (GEF) 12	28169	0.15
chr14_59485330_59485520	0.07	Cab39l	calcium binding protein 39-like	6609	0.21
chr4_130774522_130774687	0.07	Gm23711	predicted gene, 23711	1137	0.34
chr1_88587324_88587676	0.07	Gm19589	predicted gene, 19589	35983	0.13
chr7_132660508_132660703	0.07	Gm15582	predicted gene 15582	721	0.66
chr6_115658927_115659091	0.07	Raf1	v-raf-leukemia viral oncogene 1	16955	0.11
chr7_35557659_35557843	0.07	Nudt19	nudix (nucleoside diphosphate linked moiety X)-type motif 19	1447	0.28
chr10_95678111_95678450	0.07	Anapc15-ps	anaphase promoting complex C subunit 15, pseudogene	4829	0.14
chr19_23072349_23072500	0.06	C330002G04Rik	RIKEN cDNA C330002G04 gene	3429	0.24
chr4_94725954_94726107	0.06	Tek	TEK receptor tyrosine kinase	13259	0.19
chr7_16254402_16254580	0.06	C5ar1	complement component 5a receptor 1	4847	0.11
chr18_30750845_30751026	0.06	Gm41780	predicted gene, 41780	142045	0.05
chr6_71193984_71194261	0.06	Fabp1	fatty acid binding protein 1, liver	5705	0.14
chr2_50984081_50984271	0.06	Gm13498	predicted gene 13498	74492	0.12
chr15_27782797_27782987	0.06	Trio	triple functional domain (PTPRF interacting)	5746	0.25
chr4_97873061_97873239	0.06	Nfia	nuclear factor I/A	6969	0.29
chr3_92440282_92440451	0.06	Sprr1b	small proline-rich protein 1B	1577	0.18
chr8_86538609_86538876	0.06	Abcc12	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	3995	0.27
chr19_56774484_56774710	0.06	Gm6990	predicted pseudogene 6990	19251	0.14
chr2_72222793_72223023	0.06	Rapgef4os2	Rap guanine nucleotide exchange factor (GEF) 4, opposite strand 2	9394	0.17
chr16_28886318_28886476	0.06	Mb21d2	Mab-21 domain containing 2	43276	0.18
chr1_170516583_170516766	0.06	Nos1ap	nitric oxide synthase 1 (neuronal) adaptor protein	40436	0.16
chr9_50877506_50877697	0.06	Ppp2r1b	protein phosphatase 2, regulatory subunit A, beta	484	0.77
chr16_91869715_91869882	0.06	Itsn1	intersectin 1 (SH3 domain protein 1A)	7755	0.16
chr1_13267456_13267729	0.06	Gm27881	predicted gene, 27881	5394	0.14
chr7_19266055_19266214	0.06	Vasp	vasodilator-stimulated phosphoprotein	412	0.65
chr8_115856888_115857171	0.06	Gm45733	predicted gene 45733	115042	0.06
chr14_62329558_62329856	0.06	Rnaseh2b	ribonuclease H2, subunit B	2361	0.32
chr9_104331483_104331659	0.06	Acpp	acid phosphatase, prostate	6111	0.17
chr6_115901113_115901499	0.06	Ift122	intraflagellar transport 122	1321	0.32
chr11_111944397_111944560	0.06	Gm11679	predicted gene 11679	99100	0.08
chr19_42144194_42144345	0.06	Marveld1	MARVEL (membrane-associating) domain containing 1	3131	0.15
chr8_110939430_110939581	0.06	St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	1399	0.28
chr6_54762292_54762450	0.06	Znrf2	zinc and ring finger 2	54545	0.11
chr16_22886551_22886735	0.06	Ahsg	alpha-2-HS-glycoprotein	4634	0.13
chr8_35415233_35415420	0.06	Gm45301	predicted gene 45301	5820	0.18
chr13_55369651_55369802	0.06	Rgs14	regulator of G-protein signaling 14	6	0.95
chr5_3364806_3364983	0.06	Cdk6	cyclin-dependent kinase 6	20582	0.19
chr1_38242754_38242912	0.06	Gm16150	predicted gene 16150	3133	0.27
chr13_115102869_115103020	0.06	Itga1	integrin alpha 1	980	0.34
chr17_43275309_43275499	0.06	Adgrf1	adhesion G protein-coupled receptor F1	5075	0.29
chr9_112735889_112736061	0.06	Gm24957	predicted gene, 24957	213446	0.02
chr19_55808091_55808481	0.06	Ppnr	per-pentamer repeat gene	33386	0.21
chr4_47294478_47294667	0.06	Col15a1	collagen, type XV, alpha 1	6285	0.24

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Cbfb

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Total log-likelihood	Term	Description
0.1	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	GO:0030718	germ-line stem cell population maintenance(GO:0030718)
0.0	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.0	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.0	GO:0030421	defecation(GO:0030421)
0.1	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.1	GO:0035745	T-helper 2 cell cytokine production(GO:0035745)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1	GO:0070991	medium-chain-acyl-CoA dehydrogenase activity(GO:0070991)